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RADIOACTIVE SUBSTANCE APPLIED TO BODY FOR THERAPY

Subclass of:

600 - Surgery

Patent class list (only not empty are listed)

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Class / Patent application numberDescriptionNumber of patent applications / Date published
600003000 Radioactive substance placed within body (e.g., inhaled, implanted, injected, etc.) 237
600002000 Combined with other radiant or wave energy source (e.g., electromagnetic, thermal, microwave etc.) 26
Entries
DocumentTitleDate
20130085314AUTOMATIC TREATMENT PLANNING METHOD - The invention is directed to a data processing method of determining a treatment plan, a corresponding program and a computer running the program, the treatment plan describing a medical treatment to be carried out on a patient, the steps of the method being executed by a computer and comprising: 04-04-2013
20130079579DEVICE AND METHOD FOR RADIATION DOSIMETRY - A method and a device for regulating a therapeutic beam directed at an object are provided. The method includes displaying at least one multidimensional image data record encompassing at least one target area of the object. The method also includes determining the treatment beam dosage directed at the at lest one target area, and recording and optionally visualizing an isoline or isosurface dependent on the treatment beam dosage in the at least one multidimensional image data record. The method includes adjusting the isoline or isosurface such that the isoline or isosurface approximates a contour of the target area as closely as possible or corresponds to the contour, and regulating the treatment beam dosage by evaluation of the adjusted isoline or isosurface.03-28-2013
20130046127MUON MONITORING SYSTEM FOR CHARGED PARTICLE RADIATION THERAPY - A muon monitoring system for particle radiation therapy includes: a shield for a selective passing, by eliminating particles and radiation produced due to the high energy particles and radiation pulses, of the delay positrons emitted due to decay of muons stopped at a position corresponding to the Bragg peak position; a positron detector for detecting positrons from a designated direction and detecting the delay positrons passed through the shield opening by each of positron detecting plates for providing information of positron produced positions and time of delay simultaneous signals; and a control/analysis apparatus generating a delay signal at a timing delayed by a predetermined time period from a completion of irradiation of the high energy particle radiation pulses, and performing a process to generate μSR signals segmented for each positron generating position by analyzing detected results obtained by operating the positron detector for a predetermined number of times.02-21-2013
20130090514RADIATION THERAPY APPARATUS - A radiation therapy apparatus includes a gantry having a central aperture that defines a cavity, in which a patient is positionable. The apparatus also includes a positioning device, with which the patient is positionable in the central aperture of the gantry, and a radiation head for generating therapeutic radiation. The apparatus includes an extension mechanism for the radiation head. The extension mechanism may be operated, such that in a first operating mode, the radiation head is disposable inside the gantry, such that the gantry has, on a side facing the positioning device, a front surface that constitutes a front limit of the radiation therapy apparatus toward the positioning device. In the first operating mode, the radiation head is behind the front surface viewed from the positioning device. In a second operating mode, the radiation head, viewed from the positioning device, may be moved out in front of the front surface.04-11-2013
20130090513USE OF BORIC ACID IN BORON NEUTRON CAPTURE THERAPY FOR LIVER CANCER - The present invention provides a boron drug for boron neutron capture therapy for liver cancer, which is an aqueous solution of boric acid.04-11-2013
20130165732METHOD AND SYSTEM FOR ADMINISTERING RADIOPHARMACEUTICAL THERAPY (RPT) - A computerized system and method for determining an optimum amount of radiopharmaceutical therapy (RPT) to administer, comprising: performing processing associated with obtaining activity image information related to at least one agent for sub-units of at least one imaged organ from at least one detector; performing processing associated with running at least one calculation for the activity image information, using at least one computer application, to obtain absorbed dose rate image information; and performing processing associated with adding the absorbed dose rate image information, using, the at least one computer application, to obtain RPT total absorbed dose image information for the at least one imaged organ; wherein macroscopic distribution measurements that are related to microscopic or sub-unit distribution of the at least one agent are utilized.06-27-2013
20130072743METHOD AND DEVICE FOR DETERMINING A RADIOTHERAPY TREATMENT PLAN - A radiotherapy treatment plan for irradiation of an object to be irradiated is determined. The object to be irradiated includes a number of irradiation areas and the object to be irradiated is irradiated with a number of beams from different directions. The method includes determining a number of total dose conditions. One of the number of total dose conditions is assigned to a respective one of the number of irradiation areas. The method further includes determining a number of single beam dose conditions. One of the single dose conditions is assigned to a respective one of the number of beams and a respective one of the number of irradiation areas. The method also includes determining irradiation parameters for the number of beams as a function of the number of total dose conditions and the number of single beam dose conditions.03-21-2013
20130072745TRACKING REPRESENTATIONS OF INDICATOR BODY PARTS - The present invention relates to a method for tracking image sections which represent indicator body parts of a body in a process sequence of images, wherein changes in the position of the indicator body parts are used as an indicator for changes in the position of a treatment body part of the body which is to be treated using a treatment beam, said method comprising the following steps: providing advance image data which describe an advance sequence of images representing a result of an advance analysis of the body; providing process image data which describe the process sequence of images, wherein the process sequence of images represents a result of a process analysis of the body which is performed after the advance analysis; determining, on the basis of the advance image data, sub-images which undergo similar changes in position in the advance sequence; extracting, on the basis of the process image data and the determined sub-images, image sections from the images of the process sequence which have an image content which corresponds to the image content of the determined sub-images; and tracking the extracted image sections in the process sequence.03-21-2013
20130072744Multi-Leaf Collimator for Proton Beam Therapy - A proton beam collimator comprising (a) titanium or (b) stainless steel containing no tungsten or (c) containing no tungsten or brass. The collimator comprises a multi-leaf collimator (MLC). The apparatus further comprises an integrated circuit (IC) mounted adjacent the collimator, the IC subject to exposure to atomic particles, illustratively, neutrons.03-21-2013
20130072742METHOD AND APPARATUS PERTAINING TO MULTI-STAGE RADIATION-TREATMENT PLAN OPTIMIZATION - A control circuit employs at least two optimization stages while developing a radiation-treatment plan. During a first optimization stage the control circuit uses a first radiation-treatment plan optimization process that employs user-selected constraints to provide general plan results. During this first optimization stage the control circuit then provides one or more opportunities for a user to modify those user-selected constraints to thereby influence the general plan results. Eventually, this first optimization stage identifies a set of resultant user-selected constraints. During the second optimization stage the control circuit then uses a second radiation-treatment plan optimization process that employs the aforementioned resultant user-selected constraints to provide an optimized radiation-treatment plan.03-21-2013
20090082608Calculation of probable accumulated dosages based on patient movement - A stochastic patient movement model and a dosage delivery plan are used to determine probabilities of dosages received by a target volume during a radiation treatment. The stochastic patient movement model is created by identifying possible sequences of patient positions during the treatment with probabilities specified for each. The dosage delivery plan specifies dosage levels and radiation locations over time. Accumulated dosages are calculated for each sequence of patient positions and the dosage delivery plan. The specified probability for each sequence is then correlated to the accumulated dosage for that sequence.03-26-2009
20130066134Multiplexed Radiation Therapy - A radiation system is provided comprising a single source of therapeutic radiation that is directed toward at least two treatment spaces in succession. Each treatment space houses a patient to be treated, each patient being secured generally by a separate supporting device adapted to support the patient in a generally sitting or standing or horizontal position. The x-ray source first delivers at least one beam to the first patient in the first space and then the x-ray source/patient relationship is adjusted so as to deliver an at least one beam to an at least second patient in a second space.03-14-2013
20130066135NEUTRON IRRADIATION THERAPY DEVICE - A device for irradiating cancer patients with neutrons, useful in Boron Neutron Capture Therapy, using at least one neutron emitter mounted and controlled so as to deliver a measured dose of neutrons directed at a treatment site or sites.03-14-2013
20130165731APPARTUS AND METHOD TO VISUALLY VIEW HIGH-DOSE-RADIATION APPARATUS USED TO VERIFY QUALITY ASSURANCE - An apparatus for testing a high-dose-rate afterloader machine comprising an image capturing device that used to capture a plurality of still images or a real-time video, wherein said image capturing device further comprises, a zoom lens, a microphone and a light, a measurement ruler that is located on a base plate; a plurality of calibration points located on the said base plate, a source insert that connects to said high-dose-rate afterloader machine to one end, wherein said source insert allows entry of a radioactive pellet and a source wire into one end, and an adjustable shaft that is connected to said base plate and connected to said image capturing device.06-27-2013
20120238795METHOD AND DEVICE FOR CONTROLLING DOSAGE APPLICATION DURING IRRADIATION - A method for controlling dosage application during irradiation of a moveable target volume in a body with an energy beam by scanning the target volume includes, before irradiating an i-th grid position, determining a dosage during the irradiation process using the movement data, wherein the dosage already contains the i-th grid position during irradiation of the previous grid positions (1<=k09-20-2012
20100081857SYSTEM, METHOD, COMPUTER-READABLE MEDIUM, AND USE FOR PLANNING COMBINED THERAPY - A system and method for planning a necrosis-inducing therapy and subsequent administration of a necrosis-targeting agent are described. The system takes into account the effect of necrosis-induction therapy as a basis for the biodistribution estimate of the necrosis-targeting agent. This interaction between the different calculation steps is essential for an accurate planning result. A computer-readable medium and use are also provided.04-01-2010
20120253096RADIATION THERAPY APPARATUS AND CONTROL METHOD - According to one embodiment, a radiation therapy apparatus includes a radiation irradiation device, a detector included in a PET scanner, a control unit, and a PET image reconstruction unit. The radiation irradiation device emits a therapeutic radiation. The detector counts light derived from gamma rays, and is provided with a gap portion through which the therapeutic radiation passes on a plane of rotation about the body axis of a subject. The control unit controls the radiation irradiation device and the detector so as to rotate in synchronization with each other in a state capable of emitting the therapeutic radiation to the gap portion. The PET image reconstruction unit reconstructs a PET image based on position information at the time of counting of the detector that nearly coincidentally counts pair annihilation gamma rays in a state where the control unit performs rotation control.10-04-2012
20130023716DOSE CONTROL SYSTEM AND METHOD OF CONTROLLING OUTPUT DOSE OF A RADIATION THERAPY TREATMENT SYSTEM - A dose control system for a radiation therapy treatment system. The dose control system monitors the dose output and addresses the effects of rotational dose variation and drift.01-24-2013
20130023715TRACKING OF TUMOR LOCATION FOR TARGETED RADIATION TREATMENT - Systems, methods, and apparatuses are provided for targeting diseased tissue with a radiation beam. Functional models can be used to accurately obtain a location of specific tissue using sensors at identifiable locations of the patient's body. Using the relative distances between the identifiable sensor locations can allow a patient to be in various positions. The functional models can be prepared using accurate pre-treatment scans, which can be taken at various body positions (e.g., rotations and/or translations). The trajectory of the beam can be measured efficiently and accurately using beam sensors attached to a beam assembly, where a model maps the beam sensor locations to a trajectory of the beam. Further, a motion model can use measurements made during treatment to obtain a time-dependent functions of the movement of the specific tissue, the change of an optimal beam trajectory over time, or the change in input commands to a beam positioner.01-24-2013
20100113860TEMPORARY TATTOO COVER AND RELATED METHOD - A cover for protecting a temporary mark on a person's skin includes a transparent layer and an associated opaque layer, wherein the opaque layer features an opening through which the temporary mark may be located as the cover is applied. An adhesive is superimposed upon the transparent layer in order to releasably affix the cover to the temporary mark, and also to permit maintaining the cover on a backing material during transportation or storage. During use, the mark is sighted through the transparent layer and the opening in the opaque layer, and applied to the patient's skin. The opaque layer is then removed from the transparent layer, which remains in place over the temporary mark, permitting the person to bathe or otherwise participate unhindered in his or her life's routines without smudging, wearing or removing the mark.05-06-2010
20110263920ADVANCED METHODS AND SYSTEMS FOR TREATING CELL PROLIFERATION DISORDERS - The present invention relates to methods for treating cell proliferation disorders comprising (1) administering to the subject at least one activatable pharmaceutical agent that is capable of activation by a simultaneous two photon absorption event and of effecting a predetermined cellular change when activated, (2) administering at least one plasmonics-active agent to the subject, and (3) applying an initiation energy from an initiation energy source to the subject, wherein the plasmonics-active agent enhances or modifies the applied initiation energy, such that the enhanced or modified initiation energy activates the activatable pharmaceutical agent by the simultaneous two photon absorption event in situ, thus causing the predetermined cellular change to occur, wherein said predetermined cellular change treats the cell proliferation related disorder, and the use of plasmonics enhanced photospectral therapy (PEPST) and exiton-plasmon enhanced phototherapy (EPEP) in the treatment of various cell proliferation disorders, and the PEPST and EPEP agents and probes10-27-2011
20120035409BI- AND TRICYCLIC INDAZOLE-SUBSTITUTED 1,4-DIHYDROPYRIDINE DERIVATIVES AND USES THEREOF - This invention relates to novel bi- and tricyclic indazole-substituted 1,4-dihydropyridine derivatives having protein tyrosine kinase inhibitory activity, to a process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated diseases or c-Met-mediated conditions, particularly cancer and other proliferative disorders.02-09-2012
20130030237POTENTIATION OF ANTI-CANCER ACTIVITY THROUGH COMBINATION THERAPY WITH BER PATHWAY INHIBITORS - Provided herein are pharmaceutical compositions and methods of treating cancer wherein the cytotoxic activity of an anticancer agent is potentiated by the combination of base excision repair (BER) pathway inhibitors.01-31-2013
20090292156ALGORITHM AND PROGRAM FOR THE HANDLING AND ADMINISTRATION OF RADIOACTIVE PHARMACEUTICALS - An algorithm and associated program for performing method steps in the maintaining of records and generating of reports used in the processing of radioactive pharmaceuticals. The algorithm is used as the basis of a program which can accomplish this method automatically. The method involves the determination of dose, the acquisition of the materials, scheduling for the issuance of doses and for future doses, the actual monitoring and control of material and equipment disposal. The algorithm and method are also adapted for the generation of reports on a periodic basis. In short, the method performed by the algorithm allows for an automation through a computer system and this, in turn, allows for the automatic processing of the steps performed and the controls involved in the dispensing of radioactive pharmaceuticals and automatically allows for the generation of governmental and other reports therefor. 11-26-2009
20120296148Method and Apparatus Pertaining to Treatment Plans for Dynamic Radiation-Treatment Platforms - A control circuit accesses patient information and treatment-platform information and uses that information to automatically suggest a treatment plan having at least one of a given number of treatment-pathway traversals wherein the given number is permitted to be greater than one and sub-treatment-pathway traversal-based physical alterations to at least one of the dynamic elements of the dynamic radiation-treatment platform. By one approach the aforementioned patient information can refer, at least in part, to the patient's external contour and a treatment target's size and position with respect to the patient. The patient information regarding the treatment target can represent the latter as a simple symmetrical geometric shape (such as a cuboid). The treatment-platform information, in turn, can refer, at least in part, to dynamic elements of the dynamic radiation-treatment platform itself.11-22-2012
20120041251CHARGED PARTICLE CANCER THERAPY X-RAY METHOD AND APPARATUS - The invention comprises an X-ray method and apparatus used in conjunction with charged particle or proton beam radiation therapy of cancerous tumors. The system uses an X-ray beam that lies in substantially the same path as a proton beam path of a particle beam cancer therapy system. The system creates an electron beam that strikes an X-ray generation source where the X-ray generation source is located proximate to the proton beam path. By generating the X-rays near the proton beam path, an X-ray path that is essentially the proton beam path is created. Using the generated X-rays, the system collects X-ray images of a localized body tissue region about a cancerous tumor. The generated image is usable for: fine tuning body alignment relative to the proton beam path, to control the proton beam path to accurately and precisely target the tumor, and/or in system verification and validation.02-16-2012
20130217949COMBINATORIAL METHODS AND COMPOSITIONS FOR TREATMENT OF MELANOMA - The invention relates to combining targeted therapies with selected chemotherapeutics for the treatment of melanoma. The invention provides a method for inducing apoptosis in a melanoma tumor cell by reducing Akt3 activity, a method for inducing apoptosis in a melanoma tumor cell comprising contacting a melanoma tumor cell with an agent that reduces Akt3 activity to restore normal apoptotic sensitivity to a melanoma tumor cell, allowing a lower concentration of chemotherapeutic agents resulting in decreased toxicity to a patient. Also disclosed is a method for treating a melanoma comprising administering an agent that reduces Akt3 activity and an agent that reduces V599E B-Raf activity, thereby treating a melanoma tumor.08-22-2013
20130217950THERAPEUTIC APPARATUS FOR HEATING A SUBJECT - A therapeutic apparatus (08-22-2013
20120035407COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE - The present invention relates to pyrazine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.02-09-2012
20110270011USE OF OPIOIDS OR OPIOID MIMETICS FOR THE TREATMENT OF RESISTANT CANCER PATIENTS - The use of opioids or opioid mimetics is suggested for the manufacture of a medicament for the treatment of resistant cancer patients.11-03-2011
20110207986SYSTEM AND METHOD FOR RADIATION DOSE REDUCTION IN MOLECULAR BREAST IMAGING - A system and method is provided for analyzing detector data acquired during molecular breast imaging (MBI) that reduces a patient's radiation does without a reduction in image quality. The method processes and combines initial images acquired by the two gamma-camera detectors of the MBI system to produce a hybrid or composite image set having reduced noise and improved contrast. The composite image provides image quality comparable to that of traditional MBI methods, but at a lower patient radiation dose.08-25-2011
201302179517-(1,2,3-TRIAZOL-4-YL) PYRROLO [2,3-B] PYRAZINE DERIVATIVES - Compounds of the formula (I), in which R08-22-2013
20130217947Hybrid Ultrasound-Guided Superficial Radiotherapy System and Method - Systems, method and devices for detecting, analyzing and treating lesions, such as skin cancer are disclosed. Such a system can include a high-frequency ultrasound imaging device to image a lesion. The system can also include a processor that executes instructions stored in memory to perform operations, and the operations can include receiving a plurality of images of the lesion from the high-frequency ultrasound imaging device, rendering a three dimensional model of the lesion using the plurality of images from the high-frequency ultrasound imaging device and determining a treatment dosimetry based on the three dimensional model of the lesion. The system can also include a radiotherapy device to provide radiotherapy treatment to the lesion, where the radiotherapy treatment is based on the treatment dosimetry.08-22-2013
20130217948Advanced Radiotherapy Treatment Planning Optimization - A method of radiotherapy treatment planning is described. A planned target volume is identified for radiotherapy treatment and at least one volume of interest is identified. The mass, density, and total deposited energy contained in the planned target volume and the volumes of interest are identified and dose objectives are determined. At least one of the objectives is a function of the identified mass, density, or deposited energy. A composite objective function is determined using the dose objectives for the planned target volume and the volumes of interest. A near optimal solution to the composite objective function is determined to produce a radiotherapy treatment plan.08-22-2013
20080262286SPECIFIC INHIBITION OF CPLA2 ENHANCES THE EFFICACY OF RADIOTHERAPY - A method for increasing the radiosensitivity of a target tissue in a subject is disclosed. In some embodiments, the methods includes administering a cytosolic phospholipase A2 (cPLA10-23-2008
20120078028ANTIBODY DRUG CONJUGATES (ADC) THAT BIND TO 191P4D12 PROTEINS - Antibody drug conjugates (ADC's) that bind to 191P4D12 protein and variants thereof are described herein. 191P4D12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.03-29-2012
20090203952Eyelid plaque - An eyelid plaque and a method of using the plaque to treat eye cancers. The eyelid plaque is placed on the eyelid such that it defines an enclosure within which the radiation source resides. The enclosure defines a radiation shield that reduces radiation entering other organs and structures proximate the cancer being treated.08-13-2009
20120197058Grid Radiotherapy for Static and Dynamic Treatment Delivery - Some aspects include a system, method, and computer-readeable medium to divide a representation of a target volume into an array of sub-volumes; define a high dose volume to which a high dose of radiation is to be delivered; define a plurality of sampling volumes; direct an estimated dose of radiation to each sub-volume; determine whether the dose of radiation delivered to each high dose volume is at least a minimum threshold dose, and that the radiation delivered to the plurality of sampling volumes for each of the sub-volumes is at least a minimum difference less than the radiation delivered to the high dose volume; adjust the estimated dose of radiation directed to each sub-volume; and develop a radiation treatment plan, including the adjusted dose, to invoke a biological effect of spatially separated radiation.08-02-2012
20120197060RADIATION ENHANCED MACROMOLECULAR DELIVERY OF THERAPEUTIC AGENTS FOR CHEMOTHERAPY TECHNOLOGY - Described herein are anti-cancer compounds composed of a macromolecule comprising (1) at least one anti-cancer agent directly or indirectly bonded to the macromolecule and (2) at least one high Z element directly or indirectly bonded to the macromolecule that is capable of producing Auger electrons upon exposure to X-ray energy. When the compounds are exposed to low energy X-ray (e.g., kilo electron volts KeV) Auger electrons are produced by the high Z elements present in the compound. Because lower energy is required when compared to typical radiotherapy, which uses therapeutic X-ray energy in the million electron volt range (MeV), the subject experiences lower collateral damage when compared to radiation therapy. Additionally, the presence of the anti-cancer agent provides a second mechanism for killing cancer cells. Methods for making and using the anti08-02-2012
20120197059UBIQUITIN INTERACTING MOTIF PEPTIDES AS CANCER THERAPEUTICS - The present invention involves the use peptides comprising ubiquitin interacting motifs (UIMs) alone or in combination with other agents to treat diseases involving neovascularization, such as cancer.08-02-2012
20130123565Quality Assurance Device and Method in Radiotherapy - The invention relates to a method of quality assurance of an apparatus for radiotherapy (05-16-2013
20130217946CHARGED PARTICLE TREATMENT, RAPID PATIENT POSITIONING APPARATUS AND METHOD OF USE THEREOF - The invention comprises a charged particle beam, rapid patient positioning system including steps of: positioning a patient relative to a table in a substantially vertical orientation, optionally constraining motion of the patient with one or more constraints, transitioning the table through a semi-vertical orientation, such as with a robot arm, and orientating the patient and table in a substantially horizontal orientation, such as in a position for tumor therapy. Preferably, the robot arm is in common with an arm used to move the patient in traditional proton therapy. Optionally, the robot arm is used to re-orientate the patient into a substantially vertical orientation at the conclusion of a charged particle therapy session.08-22-2013
20110130614PROSPECTIVE ADAPTIVE RADIATION THERAPY PLANNING - A therapy planner (06-02-2011
20130131427INTRA-ORAL DEVICE FOR PROTECTING ORAL TISSUES DURING RADIATION TREATMENT - An intra-oral device for positioning oral tissues during medical treatment, for example, radiation treatment. The device includes upper and lower dental arch members configured to engage the maxillary and mandibular teeth or edentulous arch(es) of a patient, respectively. The upper and lower dental arch members are operatively coupled to provide a dental arch assembly. A protective element to displace or depress a patient's tongue is secured at a suitable working position with respect to the dental arch assembly. In an embodiment, provision is made for three-dimensional spatial adjustment of the protective element to a desired location, at least during initial fitting and assembly. The device is then secured to allow consistent repetition of the oral tissue positioning from treatment to treatment. The protective element may be configured to engage the tongue of a patient so that the tongue may be selectively positioned for treatment and/or diagnostic procedures.05-23-2013
20130131429METHODS AND SYSTEMS FOR TREATING CELL PROLIFERATION DISORDERS WITH PSORALEN DERIVATIVES - Psoralen compounds of Formula (I):05-23-2013
20110112351METHOD AND SYSTEM FOR EVALUATING QUALITY ASSURANCE CRITERIA IN DELIVERY OF A TREATMENT PLAN - System and method of determining whether a component of a radiation therapy system is operating within a dosimetric tolerance. The method can include the acts of generating a treatment plan for a patient, the treatment plan specifying a radiation amount to be delivered to the patient, delivering radiation to the patient according to the treatment plan, obtaining feedback during the delivery of radiation, the feedback related to one of a position, a velocity, and an acceleration for one of a multi-leaf collimator, a gantry, a couch, and a jaws, generating a mathematical model based on the feedback for one of the multi-leaf collimator, the gantry, the couch, and the jaws, calculating a delivered dose amount based on the mathematical model and treatment plan information, calculating a deviation in dose between the radiation amount specified in the treatment plan and the delivered dose amount, and determining whether the deviation in dose is within a dosimetric tolerance for the one of the multi-leaf collimator, the gantry, the couch, and the jaws.05-12-2011
20090069623METHODS AND COMPOSITIONS FOR TREATMENT OR PREVENTION OF RADIATION-INDUCED FIBROSIS - The present invention comprises methods and compositions for the treatment or prevention of radiation-induced fibrosis. Methods and compositions for the inhibition of CTGF are disclosed herein. Methods and compositions for treatment of neoplastic disease are disclosed herein. Inhibition of CTGF in humans or animals that have been exposed to ionizing radiation results in treatment or prevention of radiation-induced fibrosis.03-12-2009
20110245577COMBINATION WITH BIS (THIOHYDRAZIDE AMIDES) FOR TREATING CANCER - Disclosed herein are methods of treating a proliferative disease, such as cancer, with bis(thio-hydrazide amides) or a tautomer, pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, in combination with hyperthermia treatment. Also disclosed are methods of treating a proliferative disease, such as cancer, with bis(thio-hydrazide amides) or a tautomer, pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, in combination with radiotherapy.10-06-2011
20110118530CHARGED PARTICLE BEAM INJECTION METHOD AND APPARATUS USED IN CONJUNCTION WITH A CHARGED PARTICLE CANCER THERAPY SYSTEM - The invention comprises a charged particle beam injection method and apparatus used in conjunction with multi-axis charged particle radiation therapy of cancerous tumors. The negative ion beam source includes a negative ion beam source, vacuum system, an ion beam focusing lens, and/or a tandem accelerator. The negative ion beam source uses electric field lines for focusing a negative ion beam. The negative ion source plasma chamber includes a magnetic material, which provides a magnetic field barrier between a high temperature plasma chamber and a low temperature plasma region. The injection system vacuum system and a synchrotron vacuum system are separated by a conversion foil, where negative ions are converted to positive ions. The foil is sealed to the edges of the vacuum tube providing for a higher partial pressure in the injection system vacuum chamber and a lower pressure in the synchrotron vacuum system.05-19-2011
20110087061RADIOTHERAPY APPARATUS CONTROL APPARATUS AND SPECIFIC SITE POSITION MEASURING METHOD - A specific site location measuring method according to the present invention, includes: calculating matching degrees based on a plurality of transmission images imaged by use of radiation transmitting through a specimen and a template set; selecting a template transmission image from the plurality of transmission images based on the matching degrees; adding a new template generated based on the template transmission image, to the template set; imaging a location measurement transmission image by use of radiation transmitting through the specimen; selecting an optimal template that is the most similar to a portion of the location measurement transmission image, from the template set by performing pattern matching of each of templates of the template set with the location measurement transmission image; and calculating a specific site location based on the location measurement transmission image and the optimal template. At this time, the transmission image of the specimen has a high probability that it is similar to any template of the thus-generated templates. Therefore, in the specific site location measuring method, the specific site can be measured with higher precision.04-14-2011
20110124946FLUID TRANSFER FOR RADIATION TREATMENT APPARATUS - Techniques and systems for supplying fluid to a rotating gantry portion of a radiation treatment apparatus are disclosed where a first batch fluid is supplied to the rotating gantry when the rotating gantry is stationary a first time, discontinuing the supply when the rotating gantry is rotating, and supplying a second batch of fluid when the rotating gantry is stationary a second time. A storage component on the rotating gantry allows supplied fluid to be stored in the rotating gantry and used to shape a radiation beam and/or cool an ionizing radiation source, for example, while the rotating gantry is rotating. The techniques and systems may also be utilized to discharge a first fluid from the rotating gantry and supply a second fluid to replace the first fluid.05-26-2011
20110213192Inorganic Nanoparticles of High Density to Destroy Cells In-Vivo - The present application relates to novel excitable particles which can be used in the health sector. It more particularly relates to particles which can generate electrons and/or high energy photon when excited by ionizing radiations such as X- Rays, γ-Rays, radioactive isotope and/or electron beams, and to the uses thereof in health, in particular in human health. The inventive particles are made of an inorganic material comprising oxygen, in particular an oxide, said material having an adequate density, and can be activated in vitro, ex vivo, or in vivo, by controllable external excitation, in order to disturb, alter or destroy target cells, tissues or organs. The invention also relates to methods for the production of said particles, and to pharmaceutical or medical device compositions containing same.09-01-2011
20110130613MECHANOLUMINESCENT X-RAY GENERATOR - A device for generating x-rays has an enclosing vessel having a structure suitable to provide an enclosed space at a predetermined fluid pressure, wherein the enclosing vessel has a window portion and a shielding portion in which the shielding portion is more optically dense to x-rays than the window portion; a mechanoluminescent component disposed at least partially within the enclosing vessel; and a mechanical assembly connected to the mechanoluminescent component. The mechanical assembly provides mechanical energy to the mechanoluminescent component while in operation, and at least some of the mechanical energy when provided to the mechanoluminescent component by the mechanical assembly is converted to x-rays.06-02-2011
20120035408COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE - The present invention relates to pyrazine and pyridine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.02-09-2012
20110098522Particle Beam Treatment System - A particle beam treatment system comprising a beam generating unit for generating and adjusting the kinetic energy of a beam of charged particles, comprising at least two beam guide units for feeding the beam of charged particles to a treatment location associated with the respective beam guide unit, wherein each beam guide unit comprises at least one beam deflection unit and/or at least one beam forming unit. The at least two beam guide units are designed for different areas of the kinetic energy of the charged particles such that the at least one beam deflection unit and/or the at least one beam forming unit of each beam guide unit are tailored to the energy of the particles and/or to beam characteristics of the particle beam. The invention further relates to a particle beam treatment method and use of the particle beam treatment system.04-28-2011
20110257457RADIATION TREATMENT SYSTEMS - Disclosed are radiation treatment systems with enhanced control architectures that enable more complex treatment plans to be implemented, and radiation treatment systems with enhanced resistance to the effect of neutrons. An exemplary control architectures comprises: a digital packet network; a supervisor electrically coupled to the digital packet network and having a treatment plan; and a plurality of nodes, each node coupled to digital packet network and controlling one or more treatment-related components of the radiation treatment system; and wherein the supervisor periodically communicates control orders to the nodes over the digital packet network.10-20-2011
20120203052THERAPEUTIC REGIMEN FOR TREATING CANCER - The invention provides a method for treating cancer in a human comprising administering to the human a dose of a pharmaceutical composition comprising (i) a pharmaceutically acceptable carrier and (ii) an adenoviral vector comprising a nucleic acid sequence encoding TNF-α operably linked to a promoter, wherein the dose comprises about 1×1008-09-2012
20120203051TREATMENT OF CANCER USING THE SODIUM SALT OF A BENZOIC ACID DERIVATIVE - The present invention provides a method of treating cancer using the sodium salt of a benzoic acid derivative, alone or in combination with standard treatments such as chemotherapy and radiotherapy.08-09-2012
20120203050METALLIC NANOPARTICLES, PREPARATION AND USES THEREOF - The present application relates to activable nanoparticles which can be used in the health sector, in particular in human health, to disturb, alter or destroy target cells, tissues or organs. It more particularly relates to nanoparticles which can generate a significantly efficient therapeutic effect, when exposed to ionizing radiations. The inventive nanoparticle is a metallic nanoparticle having, as the largest size, a size comprised between about 80 and 105 nm, the metal having preferably an atomic number (Z) of at least 25. The invention also relates to pharmaceutical compositions comprising a population of nanoparticles as defined previously, as well as to their uses.08-09-2012
20080242914METHOD AND APPARATUS FOR TREATMENT PLANNING USING IMPLANTED RADIOACTIVE SEEDS - A pre-computed sensitivity function providing ex ante assessment of optimal placement of a single radioactive seed, is used for sequential placement of multiple radioactive seeds. The location of each successive seed may also be constrained by an exclusion function omitting areas in the target receiving a pre-defined dose from the preexisting seeds. This technique makes possible optimization of additional dimensions of treatment planning including using a different number of needles and using mixed seed types.10-02-2008
20110257458METHOD OF USING TUMOR CELL DEBRIS TO REDUCE BRAIN TUMOR RECURRENCE OR GROWTH - The present invention describes compositions comprising tumor cell debris, tumor lysate or tumor antigens and methods of using tumor cell debris, tumor lysate or tumor antigens for stimulating a specific immune response. The compositions may further comprise at least one TLR ligand. The stimulation of the specific immune response may be used to treat tumors, particularly, brain tumors. The treatment method may also reduce the recurrence of a tumor and/or inhibit or slow down the growth of a tumor.10-20-2011
20120302818METHOD OF UTILIZING AN IMPLANT FOR TARGETING EXTERNAL BEAM RADIATION - A method of partial breast radiation therapy includes placing within a breast cavity a substantially radio-opaque implant constructed of biocompatible material, said substantially radio-opaque implant supporting the tissue surrounding the breast cavity; and directing a radiation beam to said substantially radio-opaque implant serving as a target for delivery of radiation therapy to margins around the breast cavity, such that the radiation beam does not materially irradiate the whole of the breast.11-29-2012
20120302817METHOD FOR INCREASING MOISTURE CONTENT OF SKIN SURFACE AND IMPROVING MOISTURE-RETAINING FUNCTION OF DERMIS AND BEAUTY APPARATUS THEREFOR - A method for increasing a moisture content of a skin and improving skin elasticity by improving a moisture retaining function of a dermis without generating steam, mist and the like, and a beauty apparatus that supplies moisture to a skin are provided. A user is irradiated with positive and negative ions which are generated by using ion generation means 11-29-2012
20120302816THERAPEUTIC COMPOSITIONS AND METHODS FOR TARGETED DELIVERY OF ACTIVE AGENTS - The present invention pertains to therapeutic compositions that comprise: (1) a nanovector, (2) an active agent; and (3) a targeting agent, wherein the active agent and the targeting agent are non-covalently associated with the nanovector. The present invention also pertains to methods of treating various conditions in a subject by utilizing the above-described therapeutic compositions. Methods of making the therapeutic compositions are also a subject matter the present invention.11-29-2012
20120302815MULTI-VALENT POLY-UBL CHAIN INHIBITORS AND METHODS OF USE - A composition used to develop a reagent for investigating Ubl-modifications in cellular functions and in the treatment of cancer is provided. The composition comprises gold nanoparticle (AuNP)-ligand conjugates that include at least two components: gold nanoparticles (AuNPs) and modified ubiquitin- or ubiquitin-like interacting motif (UIM or ULIM) mimetics. In one embodiment, the modified ULM mimetic is a modified SUMO interaction motif (SIM) mimetic. According to the embodiments described herein, the compound inhibits ubiquitin- or ubiquitin-like protein (Ubl)-mediated protein-protein interactions and sensitizes cells to ionizing radiation. The modified UIM and ULIM mimetics may be conjugated to the AuNP such that each AuNP is conjugated to a plurality of modified UIM or ULIM mimetics. The modified ULIM mimetics may be conjugated to the AuNP via a thiol group.11-29-2012
20120203053SEQUENTIAL OPTIMIZATIONS FOR TREATMENT PLANNING - A method and apparatus for radiation treatment planning are described. The method includes receiving a plurality of radiation treatment-planning parameters, and sequentially optimizing the plurality of radiation treatment-planning parameters.08-09-2012
20110118529MULTI-AXIS / MULTI-FIELD CHARGED PARTICLE CANCER THERAPY METHOD AND APPARATUS - The invention relates to a method and apparatus for treatment of solid cancer. More particularly, the invention comprises a multi-axis and/or multi-field raster beam charged particle cancer therapy system. The system independently controls patient translation position, patient rotation position, two-dimensional beam trajectory, delivered beam energy, delivered beam intensity, beam movement velocity, timing of charged particle delivery, and/or distribution of radiation striking healthy tissue. The system operates in conjunction with a negative ion beam source, synchrotron, patient positioning, imaging, and/or targeting method and apparatus to deliver an effective and uniform dose of radiation to a tumor while distributing radiation striking healthy tissue.05-19-2011
20110118531MULTI-AXIS CHARGED PARTICLE CANCER THERAPY METHOD AND APPARATUS - The invention comprises a multi-axis charged particle irradiation method and apparatus. The multi-axis controls includes separate or independent control of one or more of horizontal position, vertical position, energy control, and intensity control of the charged particle irradiation beam. Optionally, the charged particle beam is additionally controlled in terms of timing. Timing is coordinated with patient respiration and/or patient rotational positioning. Combined, the system allows multi-axis and multi-field charged particle irradiation of tumors yielding precise and accurate irradiation dosages to a tumor with distribution of harmful proximal distal energy about the tumor.05-19-2011
20110118527METHOD TO DERIVE ANATOMICAL AND/OR PATHOLOGICAL STRUCTURES FROM DATA OF IMAGING TECHNOLOGIES - A method to derive anatomical and/or pathological structures from non-invasive imaging technologies is provided. Non-invasive imaging technologies are computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET), surface scans and others. Imaging data obtained by non-invasive technology is used to create a surface contour. The imaging data is transmitted to rapid prototyping apparatus readable data. At hand of this readable data the rapid prototyping apparatus establishes a positive or negative surface model, such as a fixation device, a mask or a prosthesis or other instruments for medical purposes.05-19-2011
20110118528Methods and Nutritional Formulations to Increase the Efficacy and Reduce the Side Effects of Cancer Treatment - The present invention relates to methods of protecting patients and sensitizing cancer cells in combination with chemotherapy and/or radiation therapy. More specifically, the invention provides nutritional methods and formulations that are capable of reducing cancer growth without causing chronic weight loss in patients, protecting normal cells, tissues and organs from chemotherapy and/radiation therapy, and sensitizing cancer cells against low, normal and high-dose chemotherapy. Some of the methods also impede cancer growth even without chemotherapy.05-19-2011
20110137102STEREOTACTIC INTRACRANIAL TARGET LOCALIZATION GUIDANCE SYSTEMS AND METHODS - Systems and methods of intracranial target localization using non-radiological direct surface imaging of one or more of the upper teeth.06-09-2011
20110201866BRACHYTHERAPY METHOD OF TREATING SKIN TUMORS USING A TAILOR-MADE RADIOACTIVE SOURCE - The present invention refers to a method of treating a cancerous or non-cancerous skin lesion of a subject, e.g. a human patient, by epidermal radioisotope therapy, a specialized type of brachytherapy, comprising the steps of (a) defining and marking an area of skin to be treated; (b) covering said area with a protective layer, e.g. a protective film or foil; (c) applying a tailor-made radioactive source by applying a layer of a radioactive source material on said protective layer, such that said area is covered by said material while any area not to be treated is spared; and (d) removing the radioactive source after a predetermined time period of irradiation.08-18-2011
20110218379EPITOPES DERIVED FROM SATB2 AND USES THEREOF - The present invention relates to an affinity ligand capable of selective interaction with an epitope sequence consisting of 47 amino acids or less and comprising the amino acid sequence of SEQ ID NO:1 and/or SEQ ID NO:2. Further, it relates to a polypeptide consisting of the epitope sequence and to uses of the affinity ligand and the polypeptide.09-08-2011
20100016649External Beam Radiotherapy And Imaging With Radioactive Isotope - A method of delivering external radiation beams to a target volume in a body portion includes positioning a radioactive isotope source at a plurality of locations spaced apart around the body portion, and collimating radiation beams of the radioactive isotope source from the plurality of locations, whereby the target volume in the body portion is deposited with a predetermined dose distribution. A radiation device employs a member having a configuration adapted to surround a body portion to be irradiated. The member has a channel and a plurality of collimators spaced apart along and coupled to the channel. The plurality of collimators define a plurality of dwelling locations for a radioactive isotope source in the channel and are configured to collimate radiation beams of the radioactive isotope source.01-21-2010
20110306818Irradiation of a Target Volume, Taking into Account a Volume to be Protected - The idea concerns irradiation of a target volume (12-15-2011
20100268012Radioprotective materials, methods of transport and utilization thereof, nanoscale-microscale supramagnetic and supraconducting particles, spherical flow dynamics and sonoluminesence - A spherical sonoluminesence chamber is treated with a positively charged transducer at one end and a negatively charged transducer at the other end, and a charge is applied to a medium of helium or other gas or liquid, with the anions, cat ions, or oxides of our selected particles dispersed therein. With the application of sufficient energy, a supraconducting entity is thus achieved via cooper-pair bonding, with techniques for enhancing the entity's paraconducting and supraconducting properties. Applications for using these novel entities in a variety of arenas are disclosed.10-21-2010
20120004492MARKER ADAPTED NORMAL TISSUE COMPLICATION PROBABILITY - A therapy system includes a diagnostic image scanner (01-05-2012
20120209050NOVEL PYRIDOPYRAZINE DERIVATIVES, PROCESS OF MANUFACTURING AND USES THEREOF - The invention relates to pyrido[2,3-b]pyrazine compounds of general formulae (Ia) and (Ib), to their preparation and use, for example, for the treatment of malignant disorders and other disorders based on pathological cell proliferations.08-16-2012
20110166409EGFR AND PTEN GENE ALTERATIONS PREDICTS SURVIVAL IN PATIENTS WITH BRAIN TUMORS - The invention relates to methods of predicting the clinical outcome of brain cancer patients based on the LOH levels of the PTEN gene and on the expression levels or the polysomy/amplification levels of EGFR gene in a sample from said patients.07-07-2011
20110166408HEART TISSUE SURFACE CONTOUR-BASED RADIOSURGICAL TREATMENT PLANNING - A system that generates a three-dimensional model of a tissue surface, for example the inner surface of the heart from two-dimensional image data slices. On this surface, one or more pattern lines are drawn, e.g., by a physician using a user interface, to designate desired lesion(s) on the surface. From the pattern lines, a three-dimensional volume for a lesion can be determined using known constraints. Advantageously, the series of boundaries generated by the three-dimensional volume may be projected back onto the individual CT scans, which then may be transferred to a standard radiosurgical planning tool. A dose cloud may also be projected on the model to aid in evaluating a plan.07-07-2011
20110166407Heart Treatment Kit, System, and Method For Radiosurgically Alleviating Arrhythmia - Radiosurgical treatments of tissues of the heart mitigate arrhythmias and treat other tumerous and non-tumerous disease using an implanted fiducial positioned in or near the heart using cardiac catheterization techniques. The fiducials may be implanted after diagnostic and planning images of the target tissues have been acquired. Fiducial implantation may take place the day of a scheduled radiosurgical treatment. Techniques to accommodate post-planning fiducial implantation may include registration of the implanted fiducial location with the treatment plan, and active fiducials may limit collateral imaging radiation exposure while enhancing tracking accuracy.07-07-2011
20120310030Device And Method For Line Control Of An Energy Beam - The invention relates to the field of line control of a beam, and especially to a device comprising a plurality of ionisation chambers, enabling the measurement of the dose deposited by an ionising beam and the field of said beam. At least one ionisation chamber is formed from support films having a thickness less than or equal to 100 nm.12-06-2012
20120071704MITOCHONDRIAL LOCALIZATION OF MUC1 - The invention provides methods of identifying and making compounds that inhibit the interaction between MUC1 and either or both of HSP70 and HSP90. Also embraced by the invention are in vivo and in vitro methods of inhibiting such an interaction.03-22-2012
20110092760Device For Selecting A Beam Triggering Apparatus - The present invention is related to device for selecting one of several triggering apparatuses, which are simultaneously connectable to said device. The triggering apparatuses are arranged for producing each a triggering signal to enable/disable one or more components of a radiation treatment apparatus. The triggering signals depend on detected parameters. The device includes means for receiving triggering signals from the several triggering apparatuses, when all of the apparatuses are connected to the device, input means for selecting one of the triggering apparatuses, means for generating a universal triggering signal for the one or more components on the basis of said received triggering signal from the selected triggering apparatus, and means for sending the universal triggering signal to the one or more components.04-21-2011
20110092759MOBILE SYSTEM FOR ELECTRON BEAM INTRAOPERATIVE RADIATION THERAPY - A mobile system for electron beam intraoperative radiation therapy uses a race-track microtron placed in a housing playing the role of the vacuum chamber, which is supported by a positioner providing its motion with six degrees of freedom with respect to a patient. The positioner is a part of a mobile mechanical structure which houses an ion pump, a microwave source, waveguide elements, a modulator with a pulse transformer and a cooler. The intraoperative radiation therapy system has a tube-like unit which couples the vacuum chamber with the mobile supporting mechanical structure and provides three functions, namely pumping out of the air from the vacuum chamber, feeding of the race-track microtron accelerating structure with radiofrequency power and rotation of the vacuum chamber with respect to the horizontal axis of the unit.04-21-2011
20120157746INTERACTIVE COMPUTER-AIDED EDITOR FOR COMPENSATORS USED IN RADIOTHERAPY TREATMENT PLANNING - When constructing compensators for radiation therapy using ion or proton radiation beams, a computer-aided compensator editing method includes overlaying an initial 3D compensator model on an anatomical image of a target mass (e.g., a tumor) in a patient, along with radiation dose distribution information. A user manipulates pixels or voxels in the compensator model on a display, and a processor automatically adjusts the dose distribution according to the user edits. The user iteratively adjusts the compensator model until the dose distribution is optimized, at which time the optimized compensator model is stored to memory and/or output to a machining device that constructs a compensator from06-21-2012
20120157747PULSED ELECTROMAGNETIC FIELD AND NEGATIVE PRESSURE THERAPY WOUND TREATMENT METHOD AND SYSTEM - A method for treating a wound of an individual and for enhancing a rate of wound healing by applying, for a first period of time, a negative pressure treatment to the wound without applying a pulsed radio frequency treatment; and applying, for a second period of time subsequent to the first period time, a pulsed radio frequency energy treatment to the wound while maintaining the negative pressure treatment to enhance the rate of wound healing. The negative pressure treatment and the pulsed radio frequency energy treatment are applied concurrently for the duration of the second period of time.06-21-2012
20120108880CHROMOSOME 3p21.3 GENES ARE TUMOR SUPPRESSORS - Tumor suppressor genes play a major role in the pathogenesis of human lung cancer and other cancers. Cytogenetic and allelotyping studies of fresh tumor and tumor-derived cell lines showed that cytogenetic changes and allele loss on the short arm of chromosome 3 (3p) are most frequently involved in about 90% of small cell lung cancers and greater than 50% of non-small cell lung cancers. A group of recessive oncogenes, Fus1, 101F6, Gene 21 (NPRL2), Gene 26 (CACNA2D2), Luca 1 (HYAL1), Luca 2 (HYAL2), PL6, 123F2 (RaSSFI), SEM A3 and Beta* (BLU), as defined by homozygous deletions in lung cancers, have been located and isolated at 3p21.3.05-03-2012
20110065974METHOD FOR DETERMINING AN IRRADIATION PLAN - A method for determining an irradiation plan includes specifying a target volume to be irradiated and a condition to be fulfilled, and implementing a first optimization. Implementing the first optimization includes providing a first data record, in which the target volume is mapped, and determining a first parameter set for the irradiation planning by implementing a first optimization algorithm. The first parameter set is optimized with respect to the condition to be fulfilled by using the first data record. The method also includes implementing a second optimization that includes providing a second data record that has a higher resolution than the first data record, determining a second parameter set by implementing a second optimization algorithm. The second parameter set is optimized with respect to the condition to be fulfilled by using the second data record and using the first parameter set. The method also includes generating an irradiation planning data record from the second parameter set.03-17-2011
20110105821Quick Regulation of the Range of High-Energy ION Beams for Precision Irradiation of Moving Target Volumes - The invention concerns a device and a process for adjusting the range of an ion beam, in particular for irradiation in tumor therapy. For this purpose, first the reference position of a target volume to be irradiated is determined. Subsequently, the range of an ion beam is configured such that said beam is adjusted to the reference position of the target volume, in such a manner that the Bragg peak, i.e. the maximal energy loss and thereby the maximal damage occurs in the region of the target volume which is to be destroyed. In the case that it has been determined that the reference position has been altered by a movement of the target volume, the ion beam is then deflected from the beam axis such that the ion beam is directed to various regions of a range modulator, in order that the ion beam experience a correspondingly adjusted energy loss in passing through the range modulator. This energy loss is adjusted to correspond to the change in position of the target volume in such a manner that the change in position is compensated for by the adjustment of the range of the ion beam, and the Bragg peak is returned to the region within the target volume.05-05-2011
20110105822BALLOON CATHETER AND X-RAY APPLICATOR COMPRISING A BALLOON CATHETER - The invention relates to a balloon catheter for an X-ray applicator and an X-ray applicator—for use with the corresponding balloon catheter. Said balloon catheter can be filled with a medium and comprises a balloon—that expands with respect to the volume and a catheter shaft for inserting the X-ray applicator. Said balloon or the catheter shaft comprises a rigid inner end piece in the extension of the catheter shaft.05-05-2011
20120123184SYSTEMS AND METHODS FOR OPTIMIZATION OF ON-LINE ADAPTIVE RADIATION THERAPY - Radiation treatment methods comprise: obtaining initial image data of a region of interest; initially optimizing one or more radiation delivery variables of a radiation treatment plan based on the initial image data; and dividing the plan into one or more fractional treatments. Each fractional treatment comprises: delivering an initial portion of a fraction based on the one or more initially optimized radiation delivery variables; obtaining fractional image data pertaining to the region of interest; fractionally optimizing the one or more radiation delivery variables based at least in part on the fractional image data; and delivering a subsequent portion of the fraction based on the one or more fractionally optimized radiation delivery variables. At least part of delivering the initial portion of the fraction overlaps temporally with at least one of: obtaining the fractional image data and fractionally optimizing the one or more radiation delivery variables.05-17-2012
20120123186THERAPEUTIC REGIMEN FOR TREATING CANCER - The invention provides a method for treating locally advanced resectable esophageal cancer in a human comprising (a) administering to the human a dose of a pharmaceutical composition comprising (i) a pharmaceutically acceptable carrier and (ii) an adenoviral vector comprising a nucleic acid sequence encoding a human TNF-α and operably linked to a promoter, wherein the dose comprises about 4×1005-17-2012
20120316379IMAGING OBSERVATION TIMING BASED ON RADIATION TREATMENT SYSTEM ELEMENT DELAY - Systems and methods are provided for imaging observation timing based on radiation treatment system element delay. One system includes an imaging element configured to generate a first observation of an object, the first observation being generated at a first time, wherein the object is associated with a volume of interest (VOI). The system is further configured to determine a plurality of positionings of the VOI based at least in part on the first observation of the object, determine a first radiation treatment system configuration based at least in part on one or more parameters of the plurality of positionings of the VOI, configure the radiation treatment system based on the first radiation treatment system configuration, and aid in administering of radiation, by a radiation treatment system element of the radiation treatment system, to at least a portion of the patient based on the first radiation treatment system configuration.12-13-2012
20120316378BEAM IRRADIATION APPARATUS AND BEAM IRRADIATION CONTROL METHOD - The beam irradiation apparatus is featured by including a transport pipe which is vacuum-evacuated to be used as a transport channel of a beam taken out from an accelerator, a quadrupole magnet which modulates the beam diameter of the beam so that the beam is incident on an irradiation target existing in the atmosphere while maintaining the focusing angle of the beam, and one or more longitudinally movable range shifters which are provided to be capable of changing the distance to the irradiation target of the beam, and which modulate the beam range by reducing the energy of the beam by allowing the beam to pass through the movable range shifter, and is featured in that the beam is irradiated onto the irradiation target by modulating the beam diameter and the beam range.12-13-2012
20120123185RECTAL BALLOON APPARATUS WITH PRESSURE RELIEVING LUMEN AND SENSORS - A rectal balloon apparatus comprises a shaft having a fluid passageway extending therethrough. A rectal gas relieving lumen may be positioned with the shaft for removal of rectal gas. A motion detecting sensor and a radiation detecting sensor may be positioned with the balloon, the shaft, and/or the rectal gas release lumen.05-17-2012
20120123183TELETHERAPY LOCATION AND DOSE DISTRIBUTION CONTROL SYSTEM AND METHOD - A method of adjusting an irradiation treatment plan, the plan constituted of: obtaining a plurality of reference scans of a target tissue over a breathing cycle; obtaining a pre-treatment scan of the target tissue; identifying the reference scan whose phase is consonant with the obtained pre-treatment scan; computing at least one motion vector field between the identified reference scan and another of the plurality of reference scans different from the identified reference scan; applying the at least one computed motion vector field to one of the obtained pre-treatment scan and the another of the plurality of reference scans so as to obtain at least one synthetic scan whose phase is consonant with the other of the obtained pre-treatment scan and the another of the plurality of reference scans; and adjusting one of an irradiation dose, irradiation angle and irradiation positioning responsive to the at least one synthetic scan.05-17-2012
20120123182DEVICES FOR THERMALLY INDUCED TRANSFORMATIONS CONTROLLED BY IRRADIATION OF FUNCTIONALIZED FULLERENES - An electromagnetic radiation activated device comprises a property changing material and at least one functionalized fullerene that upon irradiation of the functionalized fullerenes with electromagnetic radiation of one or more frequencies a thermally activated chemical or physical transformation occurs in the property changing material. The thermal activated transformation of the property changing material is triggered by the heating or combustion of the functionalized fullerenes upon their irradiation. The device can include a chemical agent that is embedded in the property changing material and is released when the material is heated by the functionalized fullerenes upon irradiation.05-17-2012
20110184221ELONGATED LIFETIME X-RAY METHOD AND APPARATUS USED IN CONJUNCTION WITH A CHARGED PARTICLE CANCER THERAPY SYSTEM - The system uses an X-ray imaging system having an elongated lifetime. Further, the system uses an X-ray beam that lies in substantially the same path as a charged particle beam path of a particle beam cancer therapy system. The system creates an electron beam that strikes an X-ray generation source located proximate to the charged particle beam path. By generating the X-rays near the charged particle beam path, an X-ray path running collinear, in parallel with, and/or substantially in contact with the charged particle beam path is created. The system then collects X-ray images of localized body tissue region about a cancerous tumor. Since, the X-ray path is essentially the charged particle beam path, the generated image is usable for precisely target the tumor with a charged particle beam.07-28-2011
20110184220METHODS FOR THE TREATMENT OF RADIATION OR CHEMOTHERAPY-INDUCED TISSUE DAMAGE - The present invention relates to methods for preventing or treating toxicities associated with exposure to ionizing radiation or to chemotherapy. Particularly, the present invention relates to methods for preventing or treating toxicities associated with radiation or chemotherapy comprising administering to a subject in need of such treatment polypeptide complexes comprising an IL-6 linked to a soluble IL-6 receptor, the polypeptide complexes capable of preventing or treating toxicities, particularly xerostomia.07-28-2011
20120232324Device And Method For 3D Dose Tracking In Radiation Therapy - The present invention relates to a device and method for verification of the quality of a radiation beam in conformal radiation therapy, and in particular for IMRT (Intensity Modulated Radiation Therapy) applications. The actual 3D dose distribution in the patient is tracked during the course of the entire treatment by reconstructing the photon fluences from measured 2D detector responses during irradiation in conjunction with updated patient images.09-13-2012
20120130148PHARMACEUTICAL COMPOSITION - To provide a pharmaceutical composition which can enhance the storage stability of 1-(1-hydroxymethyl-2,3-dihydroxypropyloxymethyl)-2-nitroimidazole without impairing the effect of the compound.05-24-2012
20120130147METHODS FOR THE TREATMENT OF TUMORS WITH INDANE COMPOUNDS - Compounds of the formula (I), in which R05-24-2012
20120130146CONTINUOUS ADMINISTRATION OF CILENGITIDE IN CANCER TREATMENTS - The invention relates to a combination therapy for the treatment of tumors and tumor metastases comprising the continuous administration of integrin ligands, preferably integrin antagonists, together with co-therapeutic agent or therapy forms that have synergistic efficacy when administered consecutively with said ligands, such as chemotherapeutic agents and or radiation therapy.05-24-2012
20120130145SYSTEM AND METHOD FOR PERFORMING A COMPREHENSIVE HEALTH ASSESSMENT - A system and method for providing a comprehensive overall health assessment is disclosed. A health assessment system includes first and second support structures oriented in a vertical fashion and spaced apart from one another to define a scanning area configured to receive a subject to be scanned, an x-ray imaging system incorporated into the first and second support structures and configured to acquire x-ray image data from the subject in a standing position, and at least one additional data acquisition device configured to acquire health related data from the subject. The health assessment system also includes a computer programmed to receive the x-ray image data and the health related data and generate a diagnostic output based on the x-ray image data and the health related data, the diagnostic output comprising at least one of a health related diagnosis and a recommendation for future action.05-24-2012
20120130144TREATMENT OF LUNG CANCER WITH A NITROBENZAMIDE COMPOUND IN COMBINATION WITH A GROWTH FACTOR INHIBITOR - In one aspect, the present invention provides a method of treating lung cancer, comprising administering to a subject at least one PARP inhibitor in combination with at least one growth factor inhibitor. In another aspect, the present invention provides a method of treating non-small cell lung cancer comprising administering to a subject at least one PARP inhibitor in combination with at least one growth factor inhibitor.05-24-2012
20130184512CHARGED PARTICLE BEAM IRRADIATION DEVICE - A charged particle beam irradiation device includes a particle accelerator that accelerates charged particles and ejects a charged particle beam, a cylindrical outer shell part that is capable of rotating around a rotating axis, an irradiation unit that is capable of irradiating an irradiation target with the charged particle beam, the irradiation direction of which changes in accordance with the rotation of the outer shell part, and a beam transport line that transports the charged particle beam ejected from the particle accelerator to the irradiation unit. The particle accelerator and the beam transport line may be at least partially housed within the outer shell part.07-18-2013
20120215049PARTICLE BEAM THERAPY SYSTEM - The objective is to obtain a particle beam therapy system that prevents dispersion of a charged particle beam, reduction of the energy thereof, and upsizing of the system and that can accurately monitor the opening shape of a multileaf collimator so as to perform high-accuracy particle beam therapy. An image-capturing unit that takes an image of an outer end of a respective downstream side face of a leaf plate is provided for each row of leaves in such a way as to be situated at a position that is at an outer side of an irradiation field; and adjusted in such a way that the base of a perpendicular from a viewpoint to the downstream side face, is situated at a position that is at an inner side of the position of the outer end when the leaf plate is maximally driven in the departing direction.08-23-2012
20120316377EFFECTIVE VOLUME FILLING WITH TEMPLATES - A method and a dose planning module for planning a treatment session of a patient by means of a radiation therapy system includes a radiation therapy unit having a fixed radiation focus point. The method includes obtaining a target volume of a region of a patient to be treated during a treatment of a patient in a radiation therapy unit, the target volume being modeled as a three-dimensional voxel representation; selecting an isodose level for the planned treatment; determining shots to be delivered during the treatment, each shot being modeled by a spatial dose volume distribution of radiation represented by a three-dimensional voxel representation, the shape of the spatial distribution depending on the specific collimator setting and the selected isodose level; and selecting shots in a decreasing volume order for the dose planning.12-13-2012
20120215050Method and apparatus for producing quantum entanglement and non-local effects of substances - A method and apparatus are disclosed which produce quantum entanglement and non-local effects of various substances on responsive targets such as biological and/or chemical systems through quantum entanglement. In one broad embodiment, the apparatus includes a quantum entanglement generating source, said source emitting a plurality of quantum-entangling members such as photons when said source operates; and a substance disposed adjacent to said source, said substance being responsive to said members; such that when said source emits said members which pass through said substance and a biological system, said members first quantum-entangle with quantum entities in said substance, then travel to said biological system such as a human body and subsequently entangle with quantum entities inside the biological system producing non-local effect of the substance on said biological system through quantum entanglement.08-23-2012
20120136194AUTOMATED TREATMENT PLANNING FOR RADIATION THERAPY - This patent generally relates to developing treatment plans for use in external beam radiation therapy, and more particularly to a method, a system and a computer readable media that contains programming for the development of external beam radiation therapy treatment plans. Embodiments of the invention include (1) automatically setting beam angles based on a beam angle automation algorithm, (2) judiciously designing planning structures and (3) automatically adjusting the objectives of the objective function based on a parameter automation algorithm.05-31-2012
20130172656NOVEL USE OF ARMILLARIDIN FOR TREATING CANCER - Novel Uses of an aromatic ester isolated from 07-04-2013
20120253095CREATING A COMPENSATOR FROM SOLID PARTICULATES - A patient-specific compensator is created from solid particulates on-site at a radiation treatment facility and then used there at that facility in conjunction with a radiation therapy machine to deliver radiation therapy to a cancer patient. After use, the compensator can be broken down into loose solid particulates at the facility, and another compensator can be created on-site at the facility from those particulates and used in the radiation treatment of a different cancer patient at the facility.10-04-2012
20120172650USE OF SOMATOSTATIN OR AN ANALOGUE THEREOF IN COMBINATION WITH EXTERNAL RADIATION THERAPY - Use of somatostatin or analogues thereof to enhance the effects of radiation on cellular proliferation and apoptosis, particularly use of somatostatin combined with externally applied radiation to treat neuroendocrine tumors and/or acromegaly.07-05-2012
20110207985PROMOTERS EXHIBITING ENDOTHELIAL CELL SPECIFICITY AND METHODS OF USING SAME FOR REGULATION OF ANGIOGENESIS - Isolated polynucleotide sequences exhibiting endothelial cell specific promoter activity, novel cis regulatory elements and methods of use thereof enabling treatment of diseases characterized by aberrant neovascularization or cell growth are disclosed.08-25-2011
20120215051Radiotherapeutic Apparatus - The ability to provide a fine resolution variation in the dose rate of radiotherapeutic apparatus would allow delivery times of VMAT and related techniques to be reduced significantly. A radiotherapeutic apparatus is described, comprising a source of radiation able to issue pulses of radiation at a base frequency, and a control apparatus arranged to permit pulses provided these match a pulse pattern chosen to achieve a selected time-averaged power level, the chosen pulse pattern being one selected from a plurality of pulse patterns that include patterns consisting of trains of pulses that include, relative to the base frequency, at least every n08-23-2012
20120226090Protection Against and Treatment of Ionizing Radiation - Methods of preparing a proteoliposorne comprise the step of contacting a liposome with an effective portion of RalBP1 to create a proteoliposorne. RalBP1 is effective for the protection and treatment of mammals and the environment against the accumulation of toxic compounds, and prevents accumulation of one or more toxic compounds, reduces the concentration of toxic compounds, and protects against further contamination with one or more toxic compounds. In addition, RalBP1 is effective for the protection and treatment of mammals against the effects of ionizing radiation.09-06-2012
20120083645ECG-CORRELATED RADIOTHERAPY - A method of delivering radiation includes obtaining a first signal that represents a cardiac state of the subject, and generating a control signal using a processor to operate a component of a treatment radiation machine based at least in part on the first signal. A method of delivering radiation includes determining a cardiac state of the subject, and generating a control signal using a processor to operate a component of a treatment radiation machine based at least in part on the determined cardiac state.04-05-2012
20120220811Radiation Treatment Method For Use With A Radiation Treatment Bra - A method for radiation treatment includes adjusting a plurality of adjustable elements on a radiation treatment bra to establish a reference breast geometry and aligning the patient to a radiation treatment machine by projecting a light field through windows provided in the radiation treatment bra during a radiation treatment planning session. To begin actual radiation treatment, the reference breast geometry is reestablished by repeating the original adjustments of the adjustable elements, as necessary. Alignment is re-established by viewing tattoos through the windows in conjunction with the light field.08-30-2012
20120253097DEVICE SYSTEM AND METHOD FOR TISSUE DISPLACEMENT OR SEPARATION - A tissue displacement/separation device is provided. The device includes a bladder which is expandable between a first tissue and a second tissue of a body. The bladder has an expanded shape which is selected capable of displacing or separating the first tissue from the second tissue in a manner suitable for protecting the first tissue from an effect of a treatment applied to the second tissue.10-04-2012
20120316380Pyrazolo Piperidine Derivatives as NADPH Oxidase Inhibitors - The present invention is related to pyrazolo piperidine derivatives of Formula (I), pharmaceutical composition thereof and to their use for the treatment and/or prophylaxis of disorders or conditions related to Nicotinamide adenine dinucleotide phosphate oxidase (NADPH Oxidase).12-13-2012
20120259151PYRIDOPYRAZINE DERIVATIVES AND THEIR USE - The present invention provides new pyridopyrazine compounds which are suitable for the treatment or prevention of physiological and/or pathophysiological states mediated and/or modulated by signal transduction pathways and/or enzymes in mammals and in particular in humans.10-11-2012
20120259152TREATMENT OF HYPOXIC TUMORS WITH LOCALIZED OXYGENATION - Methods and systems for treatment of hypoxic tumors are provided, including the steps of positioning a delivery device in a bodily cavity adjacent to tumor tissue, delivering an oxygenating agent to the tumor tissue via the delivery device and radiating the tumor tissue with radiation. Methods and systems of treatment of tumors are also provided, including the steps of positioning a delivery device in a bodily cavity adjacent to tumor tissue, delivering a photosensitizing agent to the tumor tissue via the delivery device, and radiating the tumor tissue with light.10-11-2012
20120190909USES OF IL-12 IN HEMATOPOIESIS - Methods for enhancing or stimulating hematopoiesis including the step of administering Interleukin-12 (IL-12) to yield hematopoietic recovery in a mammal in need. Preferred methods include the step of administering IL-12 as an adjuvant therapy to alleviate the hematopoietic toxicities associated with one or more treatment regimens used to combat a disease state. Other methods include administering IL-12 to ameliorate various hematopoietic deficiencies. Still other methods are directed to uses of IL-12 for in-vivo proliferation of hematopoietic repopulating cells, hematopoietic progenitor cells and hematopoietic stem cells. Other disclosed methods are directed to uses of Il-12 for bone marrow preservation or recovery.07-26-2012
20090030257Anti-microbial photodynamic therapy - Antimicrobial molecular conjugates for the treatment and prevention of infectious diseases caused by pathogenic microorganisms in human and animals are provided. The key to these conjugates is a special spacer connecting at least one photosensitizer to a microorganism receptor (vector) which in turn binds selectively to the surface of a microorganism bringing about photo-destruction upon irradiation. Spacers having hydrophilic structure such as ethylene glycol units and amino carboxyl end capped ethylene glycol units must be used for linking the vector to the photosensitizer. In a preferred embodiment a spacer would have at least 3 ethylene glycol units and be end capped with a carboxyl group on one end and a amino group at the other end. The present invention effectively works to combat bacterial infection in the real patient-related environments where blood, serum and other body fluids are always present or at least nearby of selected length and structure, in preferred embodiments, are used for linking the vector to the photosensitizer. These conjugate are found to be very effective in combating bacterial infection in the real patient-related environments where blood, serum and other body fluids are always present or a least nearby. A method of use is also provided.01-29-2009
20120259150Compositions and Methods of Sphingosine Kinase Inhibitors In Radiation Therapy of Various Cancers - The present invention relates to Sphingosine kinase inhibitors that are useful for treating various cancers. The invention further relates to compositions and methods of SPK inhibitors, including siRNAs, which specifically block gene expression of SPK and potentiates the effect of radiation in the treatment of various cancers.10-11-2012
20130172658POSITRON EMITTER IRRADIATION SYSTEM - Analysis of the production of 07-04-2013
20120264997EXTERNAL IMMOBILIZER - An external immobilizer for cancer treatment has a plurality of inflatable bladders that are independent finable depending on computer instruction based on patient position data provided from integrated or separate position determining means, such as external cameras or sensors, optionally with internal and/or external markers. In preferred embodiments, the immobilizer is fully integrated with an imaging means as well as the external beam radiation source, thus allowing both real time, independent anatomical compensation or correction for patient movement and fine control of beam shape and position to accurately target the tumor, even if the patient moves.10-18-2012
20120264998TREATMENT PLANNING APPARATUS AND PARTICLE THERAPY SYSTEM - A charged particle beam reduces treatment time in the uniform scanning or in the conformal layer stacking irradiation. In the uniform scanning, an optimum charged particle beam scan path for uniformly irradiating a collimator aperture area is calculated. In the conformal layer stacking irradiation, an optimum charged particle beam scan path for uniformly irradiating a multi-leaf collimator aperture area of each layer for each of the layers obtained by partitioning the target volume is calculated. Alternatively, a minimum irradiation field size that covers the multi-leaf collimator aperture area of each layer is calculated, and a scan path corresponding to the irradiation field size, prestored in a memory of a particle therapy control apparatus, is selected. The charged particle beam scan path is optimally changed in the lateral directions in conformity with the collimator aperture area in the uniform scanning or in each layer in the conformal layer stacking irradiation.10-18-2012
20120264996METHOD AND DEVICE FOR IRRADIATION TREATMENT PLANNING - A method for irradiation treatment planning for a target volume to be irradiated includes specifying a plurality of data sets. The target volume to be irradiated is depicted in each data set of the plurality of data sets. The data sets differ in that the target volume has another position and/or shape. A data set is selected from the plurality of the data sets and other data sets are registered to the selected data set. The method includes forming an amalgamation of the depicted target volumes using the registrations of the other data sets to the selected data set, and determining an area at risk in the selected data set. The method includes modifying the amalgamation of the target volumes such that the area at risk is excluded from the amalgamation of the depicted target volumes. An irradiation treatment plan is calculated using the modified amalgamation of the target volumes.10-18-2012
201202649994 (PYRROLOPYRIDINYL)PYRIMIDIN-2-YLAMINE DERIVATIVES - Compounds of the formula (I), in which R10-18-2012
20120271093Spacer For Ionized Radiation Therapy - Provided is a spacer for ionizing radiation therapy, which can be easily disposed in a living body, does not require abdominal surgery for removing the disposed spacer after radiation therapy, and can effectively separate a tissue to be treated from other tissues. The spacer for ionizing radiation therapy includes a fiber assembly obtained by three-dimensionally entangling a fibrous material formed of a biocompatible synthetic polymeric material. Specifically, the spacer has a thickness of 1 mm to 100 mm.10-25-2012
20120271095DEVICE AND METHOD FOR IMMOBILIZING PATIENTS FOR BREAST RADIATION THERAPY - According to the improved systems and methods described herein, a patient may be immobilized so that one or both breasts are returned to a known position. Additionally, the improved systems and methods reduce respiratory movement of the breasts. Thus, the immobilization devices and techniques described herein provide accurate and reproducible breast positioning while simultaneously reducing respiratory motion.10-25-2012
20120271094METHODS FOR PERFORMING RADIOSURGERY USING NON-HOMOGENEOUS STEREOTACTIC TECHNIQUES - The present invention relates to a method for performing non-homogeneous radiosurgery to provide optimal doses to the site of an abnormal lesion and to minimize damages to surrounding healthy tissues.10-25-2012
20120323062DATA PROCESSING FOR REAL-TIME TRACKING OF A TARGET IN RADIATION THERAPY - A facility for processing data is described. The facility receives a stream of digital location indications, each location indication identifying a location of a patient while undergoing radiation therapy. In response to each location indication of the string, in substantially real-time relative to the receipt of the position indication, the facility performs an action responsive to the location indication.12-20-2012
20110237859THERAPEUTIC APPARATUS - A therapeutic apparatus comprising: a magnetic resonance imaging system adapted for acquiring a set of magnetic resonance imaging data in an imaging zone, the magnetic resonance imaging system comprising a means for generating a magnetic field, a guiding means adapted for guiding a beam of charged particles to a target zone within a subject, wherein the imaging zone comprises the target zone, a zone determination means adapted for determining the location of the target zone within the subject using the set of magnetic resonance imaging data, a trajectory calculation means adapted for calculating a trajectory of the beam using magnetic field data being descriptive of the magnetic field such that the calculated trajectory reaches the target zone, a control means adapted for controlling the guiding means using the calculated trajectory such that the beam follows the calculated trajectory.09-29-2011
20120330083RADIOTHERAPY PHANTOM - The present invention relates to a phantom for use in the auditing or verification of a proposed radiation therapy regime for administration to a patient. The phantom comprises a housing which is shaped to simulate the anatomical shape of a human head and neck; and a radiation detector module configured to receive at least one radiation detector. The housing defines a cavity in which the radiation detector module can be removeably received such that the radiation detector module occupies a predetermined location within the simulated head and neck of the housing. Said predetermined location encompasses areas of the housing which simulate a target site to which it is proposed to administer radiation to the patient and a location of at least one organ that is susceptible to harm by administration of said radiation.12-27-2012
20120330084Neutron Source for Neutron Capture Therapy - A therapy apparatus for producing thermal neutrons at a tumor site in a patient has a plurality of fast neutron sources surrounding a moderator, a fast neutron reflecting media around the fast neutron sources, a gamma-ray and neutron shielding media surrounding the fast neutron reflecting media, and a patient chamber positioned inside the moderator. The fast neutron sources are positioned around the moderator to maximize and direct the neutron flux to said tumor site.12-27-2012
20120330085SYSTEM AND METHOD FOR CALIBRATING AND POSITIONING A RADIATION THERAPY TREATMENT TABLE - A system and method for calibrating and positioning a radiation therapy treatment table with a high degree of precision and accuracy. The treatment table includes radiographic indexing markers embedded or inlaid therein. The radiographic indexing markers can include a density different from density of the table material, or a radio-frequency or magnetic contrasting matter, something that the imaging system and detector of the radiation therapy system can detect, so that when scanned, with or without a patient or phantom on the table, the precise location of the patient treatment table in the x, y and z planes is known. This is important so that the table may be reconstructed, alone or with a phantom on it, by the radiation therapy system software, providing a very good indication of where the table top is prior to treatment.12-27-2012
20120330086Rapid Range Stacking (RRS) for Particle Beam Therapy - According to one general aspect there is a position and tracking module used for a patient position and locating a region of interest, a scanning routine module used for targeting the target voxel within the region of interest by accessing a treatment plan characterization while providing a maximum amount of dose to the target voxel, wherein the scanning routine module determines a maximum amount of dose for the target voxel in all a horizontal index in a single vertical index; and a beam delivery module used for controlling a beaming device that delivers ion particles to the target voxel within the region of interest, wherein the beam delivery module controls a power supply for a horizontal magnet and a vertical magnet by retrieving information from the scanning routine module, wherein the beam delivery module controls a power supply for an accelerator energy selection.12-27-2012
20120289760CYTOMEGALOVIRUS-BASED IMMUNOGENIC PREPARATIONS - This disclosure relates to methods of using recombinant replication-deficient cytomegalovirus (CMV) to generate a long-term, repeatedly stimulated T cell-based immune response in a subject, for instance against a heterologous antigen expressed by the cytomegalovirus. It further relates to methods of using a recombinant replication deficient CMV as an anti-cancer immunogenic preparation.11-15-2012
20120289759INTERLOCKING VACUUM CUSHION - A method of positioning, holding, and immobilization of a patient on a radiation treatment table or patient support surface. The positioning device is an improved vacuum cushion for the immobilization of a patient's full body on a support surface for some type of therapy to be accurately delivered and repeated. The patient's body is to be positioned in a manner for treatment that can be reproduced during consecutive days of radiotherapy. The upper and lower body cushions both include an outer casing with a valve that is connectable to a vacuum source. The casings contain small spheres. The immobilization device is comprised of upper and lower body cushions, both non-porous, to be evacuated of air. The cushions are adjoined by interlocking frame members fixed at proximal ends of each cushion. The device can be secured on the support surface at predetermined points using commercially available indexing bars during the procedure.11-15-2012
20120289757Method, device and system for modulating an activity of brown adipose tissue in a vertebrate subject - Devices, systems, and methods are disclosed herein for treatment of a disease, disorder, or condition in a vertebrate subject. A device is provided that includes one or more cooling elements configured to be applied to one or more tissues of a vertebrate subject to modulate at least one activity of brown adipose tissue of the vertebrate subject, wherein at least a portion of the one or more cooling elements is configured to be implantable, and a programmable controller configured to provide instructions to the one or more cooling elements in response to information regarding one or more physiological conditions of the vertebrate subject.11-15-2012
20120289758Method, device and system for modulating an activity of brown adipose tissue in a vertebrate subject - Devices, systems, and methods are disclosed herein for treatment of a disease, disorder, or condition in a vertebrate subject. A device is provided that includes one or more cooling elements configured to be applied to one or more tissues of a vertebrate subject to modulate at least one activity of brown adipose tissue of the vertebrate subject, and a programmable controller configured to provide instructions to the one or more cooling elements in response to information regarding one or more physiological conditions of the vertebrate subject.11-15-2012
20130012754MICROWAVE INDUCED PHOTODYNAMIC THERAPY - A method of administering photodynamic therapy includes using a microwave frequency-sensitive light-emitting polymer as a light source to excite a administered photosensitizer to exert cytotoxicity in situ at a site containing undesired or diseased tissue.01-10-2013
20130018215ESOPHAGEAL STENT AND METHODS FOR USE OF SAME - Disclosed herein are various embodiments of esophageal stents and related methods for the treatment of esophageal dysphagia. Esophageal stents, according to the present disclosure, may have a diameter between 8 mm and 16 mm. Further, esophageal stents according to the present disclosure may have a length between 40 and 150 mm. A method, according to the present disclosure, may include the steps of placing an esophageal stent across an esophageal stricture, treating an underlying cause of the esophageal stricture, and retrieving the esophageal stent following migration of the esophageal stent. The esophageal stents of the present disclosure may be configured to avoid radial and other forces that cause undue strain and/or stretching of the esophageal tissue.01-17-2013
20110160513SYSTEM AND METHODS FOR USING A DYNAMIC GAMMA KNIFE FOR RADIOSURGERY - The present invention is a method and system for developing a dynamic scheme for Gamma Knife radiosurgery based on the concept of “dose-painting” to take advantage of robotic patient positioning systems on the Gamma Knife C and Perfexion units. The spherical high dose volume created by the Gamma Knife unit will be viewed as a 3D spherical “paintbrush”, and treatment planning is reduced to finding the best route of this “paintbrush” to “paint” a 3D tumor volume. Under the dose-painting concept, Gamma Knife radiosurgery becomes dynamic, where the patient is moving continuously under the robotic positioning system.06-30-2011
20130023718Method and Apparatus Pertaining to Optimizing a Radiation-Treatment Leaf-Sequence Plan - Determine first information regarding physical-movement limitations pertaining to at least one multi-leaf collimator and also determine second information regarding movement of the treatment target with respect to the given patient. Then, while optimizing a radiation-treatment leaf-sequence plan, constrain individually-planned leaf positions as a function, at least in part, of the first information, the second information, and planned positions of adjacent leaves. By one approach, the first information can comprise information regarding a speed (such as a maximum speed) at which individual leaves of the multi-leaf collimator are able to move during a treatment session. By one approach, the second information can comprise information regarding a distance (such as a maximum distance) that one or more parts of the treatment target may possibly move as compared to a presumed position used during the optimizing of the radiation-treatment leaf-sequence plan.01-24-2013
20130023717Bladder and/or Rectum Extender with Exchangeable and/or Slideable Tungsten Shield - A shielding device includes two elongated, parallel tubes joined at a distal portion, and a shield at least one of removably and slidably situated at the distal portion. An assembly includes an applicator configured for a treatment site, an assembly block attached to the applicator, at least one rotary unit configured to be rotatably received in the assembly block, and at least one shielding device that is configured to be movably received in a respective rotary unit. A method of using the shielding device with an applicator includes inserting the distal portion of the shielding device to a treatment site, and adjusting a position of the distal portion relative to a distal end of the applicator.01-24-2013
20130023714Medical and Imaging Nanoclusters - In one embodiment the present invention discloses a nanocluster or a nanorose composition comprising two or more closely spaced nanoparticles each comprising one or more metals, metal oxides, inorganic substances, or a combination thereof and one or more stabilizers. The stabilizers are in contact with the two or more closely spaced nanoparticles to form a nanocluster composition in which the inorganic weight percentage is greater than 50% and the average size is below 300 nm, and the nanocluster composition has magnetic properties, optical properties or a combination of both.01-24-2013
20130178688SEQUENCING SECTOR FIELDS - A method for planning a treatment session of a patient and optimizing the treatment time for a treatment using a radiation therapy system includes a radiation therapy unit having a fixed radiation focus point. During an optimization of a treatment plan for a patient, a set of shots to be delivered to a plurality of isocenter positions within a target volume of a patient during a treatment session are determined and a beam-on time for each respective sector and state for each isocenter during which radiation is to be delivered are determined based on the treatment plan. For each isocenter position, sectors and states of respective sector are grouped in accordance predetermined rules with respect to beam-on times for respective state of the sectors, wherein sectors and respective states are aggregated for simultaneous delivery of radiation during a predetermined period of time.07-11-2013
20130178689TARGETS FOR GENERATING IONS AND TREATMENT APPARATUSES USING THE TARGETS - Provided is an ion beam treatment apparatus including the target. The ion beam treatment apparatus includes a substrate having a first surface and a second surface opposed to the first surface, and including a cone type hole decreasing in width from the first surface to the second surface to pass through the substrate, wherein an inner wall of the substrate defining the cone type hole is formed of a metal, an ion generation thin film attached to the second surface to generate ions by a laser beam incident into the cone type hole through the first surface and strengthen, and a laser that emits a laser beam to generate ions from the ion generation thin film and project the ions onto a tumor portion of a patient. The laser beam incident into the cone type hole is focused by the cone type hole and is strengthened.07-11-2013
20130178690RADIOTHERAPY APPARATUS CONTROLLER AND RADIOTHERAPY APPARATUS CONTROL METHOD - A radiotherapy apparatus control method includes: collecting a planning-stage position where a patient is arranged during a planning stage; collecting a position-adjusting-stage position where the patient is arranged during a position-adjusting stage; calculating a treatment-stage position, a gantry-angle offset value and a ring-angle offset value such that an orientation in which an irradiation head is arranged with respect to the treatment-stage position, when a ring is arranged while deviating from a ring angle by the ring-angle offset value and a gantry is arranged while deviating from a gantry angle by the gantry-angle offset value, coincides with an orientation in which the irradiation head is arranged with respect to the planning-stage position, when the ring is arranged at the ring angle and the gantry is arranged at the gantry angle. After that, the patient is arranged at a patient position.07-11-2013
20080221381Recharge Device for Brachytherapy of Tumors - A reloading device for brachytherapy of tumors is to be simplified in terms of the replacement of the radiation source at the irradiation site. At least two tubes are provided for receiving a longitudinally displaceable cable at the end of which a radiation source can be applied. The tubes can be connected, via a source replacement device and a shield, to a removable and adjustable distributor, from which lines lead to the tumor. By adjusting the distributor, the respectively desired line can be oriented to the respectively desired tube and in this way the desired radiation source can be introduced preferably step by step into the tumor.09-11-2008
20130144104RADIATION SYSTEMS WITH MINIMAL OR NO SHIELDING REQUIREMENT ON BUILDING - A radiation system includes a support, a capsule rotatably coupled to the support, a radiation source movably coupled to the capsule, wherein the radiation source is configured to provide a treatment radiation beam, and is capable of being turned on or off in response to a control signal, and a collimator located next to the radiation source, wherein the capsule defines a space for accommodating a portion of a patient, and includes a shielding material for attenuating radiation resulted from an operation of the radiation source, and wherein the shielding material is configured to limit a radiation exposure level to 5 mR/hr or less within 3 meters from an isocenter.06-06-2013
20130172657INTEGRATED RADIATION THERAPY SYSTEMS AND METHODS FOR TREATING A TARGET IN A PATIENT - An integrated radiation therapy process comprises acquiring first objective target data related to a parameter of a target within a patient by periodically locating a marker positioned within the patient using a localization modality. This method continues with obtaining second objective target data related to the parameter of the target by periodically locating the marker. The first objective target data can be acquired in a first area that is apart from a second area which contains a radiation delivery device for producing an ionizing radiation beam for treating the patient. The localization modality can be the same in both the first and second areas. In other embodiments, the first objective target data can be acquired using a first localization modality that uses a first energy type to identify the marker and the second objective target data can be obtained using a second localization modality that uses a second energy.07-04-2013
20130137915FLEXIBLE ENERGY FILTER FOR ION BEAM THERAPY - An energy filter allows, particularly at lower beam energies, a determined spread of the beam energies in order to preserve the beam edges and to spread the Bragg peak at each individual beam energy. The energy filter behaves similarly to a ridge filter and spreads out the Bragg peak of a low energy proton beam (70-100 MeV) so that energy modulation of the beam can be done with steps of 5 mm in one go over the full range of 235-70 MeV. Due to its mechanical flexibility, the energy filter can be placed on the skin of the patient which minimizes the effect of scattering in the filter due to the short distance behind a layer of a plurality of metal particles within a flexible soft plastic sheet to the skin of the patient.05-30-2013
20130137916RADIOTHERAPY COMBINED WITH HYPOXIC CELL SENSITIZERS - The invention discloses a method of treating cancer in a patient, comprising administering to the patient a radiation sensitizer selected from nitroimidazoles in an amount effective to sensitize a patient to radiation and subjecting the patient to radiation therapy. In certain embodiments the radiation sensitizer is etanidazole or doranidazole.05-30-2013
20130102830SYSTEM AND METHOD FOR ESTIMATING AND MANIPULATING ESTIMATED RADIATION DOSE - Methods are provided for permitting manipulation of an achievable dose distribution estimate deliverable by a radiation delivery apparatus for proposed treatment of a subject. One such method comprises: determining a dose modification voxel for which it is desired to modify the dose value and a corresponding magnitude of desired dose modification; for each of a plurality of beams: (i) characterizing the beam as a two-dimensional array of beamlets, wherein each beamlet is associated with a corresponding intensity value and a ray line representing the projection of the beamlet into space; and (ii) identifying one or more dose-change beamlets which have associated ray lines that intersect the dose modification voxel; modifying the intensity values of at least one of the dose-change beamlets; and updating the achievable dose distribution estimate to account for the modified intensity values of the at least one of the dose-change beamlets.04-25-2013
20130102829METHOD FOR TREATING OSTEOSARCOMA BY BORON NEUTRON CAPTURE THERAPY USING BORIC ACID AS A BORON DRUG - The present invention provides a treatment of osteosarcoma by boron neutron capture therapy using boric acid as a single boron drug.04-25-2013
20130131423Methods to detect and treat diseases - The current invention discloses methods to treat disease caused by virus infection, bacterial infection, parasites infection, autoimmune disease, disease caused by production of unwanted antibodies, sepsis as well as methods to treat cancer and methods for virus infection detection using blood purification method. The current invention provides a method to treat pathogen infection by inactivating the pathogens in the blood. During the treatment, blood is withdrawn from a patient and is separated into its plasma and cellular components. The plasma portion is treated with physical means such as UV radiation to inactivate the pathogens inside and then is returned to the patient. The current invention also provide a method to treat cancer especially to prevent tumor metastasis and tumor recurrence by removing and/or inactivating (e.g. killing) the circulating tumor cells (CTC) in the blood after removing the tumor or treating the tumor with therapeutical means.05-23-2013
20130131430NON-PLANAR TREATMENT BEAM CONTROL - The present invention relates to a data processing method for determining control data for controlling beam positions which beam positions describe positions which a treatment beam has or would have if emitted by a beam source, the treatment beam being for treating a treatment body part of a patient, said method constituted to be performed by a computer and comprising the steps of: • providing treatment data which comprise data on a position of the treatment body part; • providing condition data which describe: constraints on the beam positions and/or constraints on positional changes of the beam positions, wherein said constraints allow for at least a part of the beam positions to lie not in a common plane; • providing an arrangement of the beam positions on the basis of the treatment data which arrangement fulfils the condition data; • determining control data for controlling a change of a relative position of the beam source relative to the treatment body part for changing the beam positions and for controlling an emission of the treatment beam from the beam source, the determined control data being constituted to change the beam positions to follow the provided arrangement of the beam positions and to cause continuous emission of the treatment beam during a continuous change of the beam positions while the beam positions follow at least a part of the arrangement.05-23-2013
20130131425Heart Treatment Kit, System, and Method for Radiosurgically Alleviating Arrhythmia - Radiosurgical treatments of tissues of the heart mitigate arrhythmias and treat other tumerous and non-tumerous disease using an implanted fiducial positioned in or near the heart using cardiac catheterization techniques. The fiducials may be implanted after diagnostic and planning images of the target tissues have been acquired. Fiducial implantation may take place the day of a scheduled radiosurgical treatment. Techniques to accommodate post-planning fiducial implantation may include registration of the implanted fiducial location with the treatment plan, and active fiducials may limit collateral imaging radiation exposure while enhancing tracking accuracy.05-23-2013
20130131428OPTIMIZATION PROCESS FOR VOLUMETRIC MODULATED ARC THERAPY - Systems, techniques, and processes are disclosed for implementing aperture-based optimization techniques. In one aspect, a method performed by an aperture-based radiation treatment system includes implementing a volumetric modulated arc therapy (VMAT) treatment plan by generating apertures at beam angles. Beam intensities of the generated apertures are determined, which can be used to control generation of a radiation dose in a radiation therapy.05-23-2013
20130131424Programmable Particle Scatterer For Radiation Therapy Beam Formation - Interposing a programmable path length of one or more materials into a particle beam modulates scattering angle and beam range in a predetermined manner to create a predetermined spread out Bragg peak at a predetermined range. Materials can be “low Z” and “high Z” materials that include fluids. A “high Z” and, independently, a “low Z” reservoir, arranged in series, can be used.05-23-2013
20130131426Radiosurgical Ablation of the Myocardium - The invention provides a non-invasive system and method for treatment of the heart. In a first aspect, a method for treatment of an anatomical site related to arrhythmogenesis of a heart of a patient comprises creating a target shape encompassing the anatomical site, directing particle beam radiation or x-ray radiation from outside the patient toward the target shape wherein one or more doses of radiation ablates the target shape and disregarding at least one orientation of cardiac motion while creating the target shape or directing the particle beam or both.05-23-2013
20130131422SYSTEMS AND METHODS FOR COMMUNICATING DOSE CALIBRATION INFORMATION - Systems and methods for communicating dose calibration information are provided. One method includes determining dose calibration information of a radiopharmaceutical at a dose calibrator. The method also includes automatically storing the dose calibration information in a memory. The method further includes communicating the stored dose calibration information to a host system.05-23-2013
20130131431CONTROL UNIT OF RADIOTHERAPY APPARATUS AND RADIOTHERAPY APPARATUS CONTROLLING METHOD - A radiotherapy apparatus controlling method according to the present invention includes controlling an imager driving unit to move an imaging unit to a position, and to image a transmission image by the imaging unit based on a radiation emitted from a first irradiating unit; and controlling the imager driving unit to move the imaging unit to a position, and to image a transmission image based on a radiation emitted from a second irradiating unit. According to such a radiotherapy apparatus controlling method, it is not necessary to separately provide an imaging unit which images the transmission image using a first radiation emitted from the first irradiating unit and an imaging unit which images a transmission image from the radiation emitted from the second irradiating unit, and a radiotherapy apparatus can be manufactured to be cheaper.05-23-2013
20110224476Method and Apparatus for Treatment of Discogenic Pain - A back pain treatment system includes a patient support, a radiation source, a radiation delivery mechanism, and a treatment planning computer adapted to control the radiation delivery mechanism. The treatment planning computer is programmed to deliver radiation from the radiation source to a treatment volume including a blood vessel.09-15-2011
20110224475ROBOTIC MOBILE ANESTHESIA SYSTEM - A mobile anesthesia system has a patient support configured for use with a robotic patient positioning system. There is a sliding rail system disposed on the patient support and an anesthesia machine coupled to the slide rail system. Through use of the rail system(s) on the patient support a anesthesia machine may move relative to a patient support from a stored configuration clear of the patient to a treatment configuration above the patient. A method of providing anesthesia to a patient positioned to receive a robotic assisted radiation therapy is also described. The method proceeds by positioning a patient on a robotic couch in a location remote to a radiation therapy treatment room used to perform the robotic assisted radiation therapy. Next, anesthesia is administered to the patient from an anesthesia machine attached to the robotic couch while both the patient and the robotic couch are in the location remote to the radiation therapy treatment room. Thereafter, the robotic couch is placed under the control of a patient positioning system in the radiation therapy treatment room. The patient and the robotic couch are then maneuvered into a treatment position while administering anesthesia to the patient from the anesthesia machine.09-15-2011
20110237858Device and Methods for Sequential, Regional Delivery of Multiple Cytotoxic Agents and Directed Assembly of Wound Repair Tissues - An implantable delivery system includes a macrostructure formed of bioresorbable material selected from a group of alphahydroxy acids and defined to include an internal architecture of intercommunicating void spaces. A first cytotoxic agent in the preferred form of cisplatin is joined to the macrostructure during formation. A microstructure in the preferred form of a blend of high molecular weight hyaluronic acid conjugated with a second cytotoxic agent in the preferred form of paclitaxel and of pure high molecular weight hyaluronic acid is invested in the void spaces. Thus, when implanted, the paclitaxel and cisplatin are released sequentially, each initially at high level concentrations followed by lower release. Radiotherapy can be begun after the release of the paclitaxel has been completed but while the cisplatin is being released.09-29-2011
20130150645METHOD AND DEVICE FOR REGISTRATION AND IMMOBILIZATION - Support devices and pods for the head and neck region of patients undergoing radiation therapy are provided herein. The pod generally includes a support shell shaped to generally conform to the shape of the head and neck region of the patient, a foam insert that conforms to the head and neck region of the patient, and an immobilization facemask attached directly to the shell, thereby facilitating close placement of the radiation beam delivery device to the patient and reducing any attenuation and perturbation of radiation doses directed at the patient. The components of the pod are made from materials having properties that reduce any attenuation and perturbation of prescribed radiation doses.06-13-2013
20130150646Method for the Operation of a Radiotherapy System and a Radiotherapy System - A method for calculating local part radiation doses in a radiotherapy system for applying a total radiation dose in a target volume with several beams is provided. The method includes determining at least one first control plane for controlling the dosing of the beams, determining at least one second control plane for controlling the positioning of the beams, and allocating beams to the first and second control planes. The method also includes, for at least one side of a first control plane, calculating in isolation of the corresponding local part radiation doses of all the beams allocated to the first control plane.06-13-2013
20130150647Irradiation Planning for Particle Therapy - A method for producing an irradiation plan for a target volume includes preparing a modulation curve that characterizes modulation of particle numbers at target points in the target volume that lie one behind another in a direction of the beam. The method also includes determining a current position of the target volume and defining a plurality of target points that fully cover the target volume in the current position. Particle numbers are assigned to the plurality of current target points using the modulation curve.06-13-2013
20130150649SENSITIZATION OF TUMOR CELLS TO RADIATION THERAPY THROUGH ADMINISTRATION OF ENDOTHELIN AGONISTS - Methods to sensitize tumor cells to radiation therapy through the administration of an endothelin agonist such as the ET06-13-2013
20130150648INCLINED BEAMLINE MOTION MECHANISM - A radiotherapy particle emitter positioning device is provided. The positioning device includes first and second arcuate support frames, a mounting carriage and a drive arrangement. The first and second arcuate support frames each include a drive track arrangement defining an arcuate carriage guide path. The mounting carriage is configured for supporting the radiotherapy particle emitter. The mounting carriage is mounted to and supported by the support frames. The mounting carriage is connectable to the drive track arrangements and moveable along the carriage guide path. The mounting carriage also includes the drive arrangement. The drive arrangement engages the drive track arrangements for driving the mounting carriage along the drive track arrangements and the carriage guide path.06-13-2013
20130158337METHOD AND DEVICE FOR PREVENTING OR TREATING ATOPIC DERMATITIS - A method for preventing or treating atopic dermatitis of a patient by covering the patient itself or a patient's area affected by the atopic dermatitis, filling a covered space with positive ions composed of H06-20-2013
20130158336USE OF NANOPARTICLES IN THE PHOTODYNAMIC TREATMENT OF TUMORS AND NON-DESTRUCTIVE TESTING - A method for generating light intensity inside a tumor to aid in the treatment of diseases such as cancer is disclosed. The light is generated inside the body to perform a modified photodynamic therapy treatment (PDT) that allows treatment of body regions that are inaccessible by normal PDT procedures. In addition, the use of two spatially and temporally coincident treatment modalities, i.e. radiation and PDT, have the potential for significant biological synergy in the tumor.06-20-2013
20130184513SKIN CARE METHOD AND SKIN CARE DEVICE - A skin care method using a closed-bottomed casing 07-18-2013
20130184511Radiosurgical Neuromodulation Devices, Systems, and Methods for Treatment of Behavioral Disorders by External Application of Ionizing Radiation - Radiosurgical techniques and systems treat behavioral disorders (such as depression, Obsessive-Compulsive Disorder (“OCD”), addiction, hyperphagia, and the like) by directing radiation from outside the patient toward a target tissue within the patient's brain, typically without imposing surgical trauma. The target will often be included in a neural circuit associated with the behavioral disorder. A cellularly sub-lethal dose of the radiation may be applied and the radiation can mitigate the behavioral disorder, obesity, or the like, by modulating the level of neural activity within the target and in associated tissues. Hypersensitive and/or hyperactive neuronal tissue may be targeted, with the radiation downwardly modulating hyperactive neuronal activity. By down-regulating the activity of a target that normally exerts negative feedback or a limiting effect on a relevant neural circuit, the activity of the circuit may be increased.07-18-2013
20130123566RADIATION SENSITIZATION AGENTS FOR PROSTATE CANCER - Compositions and methods are provided for sensitizing neoplastic cells to radiotherapy. The invention provides aptamer-inhibitory nucleic acid chimeras that selectively inliibit the expression of radiosensitizing genes in neoplastic cells expressing a cell surface molecule that binds the aptamer.05-16-2013
20110313232Multi-Field Charged Particle Cancer Therapy Method and Apparatus - The invention relates generally to treatment of solid cancers. More particularly, the invention relates to a multi-field charged particle cancer therapy method and apparatus coordinated with negative ion beam creation, ion beam focusing, charged particle acceleration, patient rotation, and/or patient respiration. Preferably, the charged particle therapy is performed on a patient in a partially immobilized and repositionable position. Proton delivery is preferably timed to patient respiration via control of charged particle beam injection, acceleration, and/or targeting methods and apparatus.12-22-2011
20110313231RADIATION SYSTEMS - A radiation system includes a first ring, a radiation source capable of providing radiation suitable for treating a patient, the radiation source secured to the first ring, a second ring located behind the first ring, and an imager secured to the second ring. A radiation system includes a first device having a radiation source capable of generating a radiation beam suitable for treating a patient, and a second device having imaging capability, wherein the first device is oriented at an angle that is less than 180° relative to the second device. A radiation system includes a structure having a first opening, a radiation source rotatably coupled to the structure, an imaging device rotatable relative to the structure, and a processor for controlling a rotation of the radiation source and a rotation of the imaging device, wherein the radiation source is rotatable relative to the imaging device.12-22-2011
20110313230SPECIFIC BINDING PROTEINS AND USES THEREOF - The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to EGFR on tumor cells that overexpress EGFR, and on tumor cells that express the truncated version of the EGFR receptor, de2-7 EGF. In particular, the epitope recognized by the specific binding members, particularly antibodies and fragments thereof, is enhanced or evident upon aberrant post-translational modification. These specific binding members are useful in the diagnosis and treatment of cancer. The binding members of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof.12-22-2011
20110313229Therapy Targeting Cancer Stem Cells - Disclosed herein are new immunotherapy methods that involve the isolation of cancer stem cells from tumor tissue and use of the cells either directly or indirectly through proteins or other factors associated with the cells to activate antigen presenting cells. The activated antigen presenting cells are useful as a therapy against the tumor. Also disclosed herein are novel methods of isolating and characterizing cancer stem cells and producing individual cancer stem cell lines. Dendritic cell lines are also disclosed herein.12-22-2011
20110313228RADIOTHERAPY APPARATUS CONTROL METHOD AND RADIOTHERAPY APPARATUS CONTROL APPARATUS - A radiotherapy apparatus control method according to the present invention includes: a step S12-22-2011
20130190548BEAM POSITION MONITOR AND PARTICLE BEAM THERAPY SYSTEM - A charged particle beam position monitor is provided with a plurality of position monitors and a beam data processing device that performs calculation processing of the state of a charged particle beam, based on a plurality of signals outputted from the position monitors. The beam data processing device includes a plurality of channel data conversion units that perform AD conversion processing of the plurality of signals outputted from the position monitors; a position size processing unit, for each of the position monitors, that calculates the beam position of the beam, based on voltage information obtained through the AD conversion processing; and an integrated control unit that controls the plurality of channel data conversion units in such a way that while the beam is irradiated onto an irradiation subject, AD conversion processing of the signals is performed at different timings for the respective position monitors.07-25-2013
20120029261SYSTEMS AND METHODS FOR DELIVERY OF A THERAPEUTIC AGENT - Methods and apparatus are provided for applying an fragment of a neurotoxin such as the active light chain (LC) of the botulinum toxin (BoNT), such as one of the serotype A, B, C, D, E, F or G botulinum toxins, via permeabilization of targeted cell membranes to enable translocation of the botulinum neurotoxin light chain (BoNT-LC) molecule across the targeted cell membrane to the cell cytosol where a therapeutic response is produced in a mammalian system. The methods and apparatus include use of catheter based delivery systems, non-invasive delivery systems, and transdermal delivery systems.02-02-2012
20120029260Screening and Treatment Method - The invention provides a method to analyze an effect of a biological insult such as exposure to ionizing radiation comprising (a) exposing one or more groups of subjects to a biological insult of at least about an LD02-02-2012
20130197294METHOD AND APPARATUS PERTAINING TO CONFIGURING A RADIATION-DELIVERY TREATMENT PLAN - A radiation-delivery treatment plan includes a first value for a limit as pertains to motion compensation-based adjustment of a radiation-delivery parameter during a first portion of a radiation treatment session as well as a second value for that same limit during a second, different portion of the treatment session. By one approach, the radiation-delivery treatment plan selects between this first and second value as a function of a preselected parameter. Examples of such parameters include, but are not limited to, radiation-beam orientation parameters (such as a gantry-based parameter) and/or any of a variety of external surrogates.08-01-2013
20120041250TARGET TRACKING DEVICE AND RADIATION THERAPY APPARATUS - An X-ray fluoroscopic unit simultaneously acquires a plurality of X-ray fluoroscopic images with different sensitivities in one direction. An image processing unit detects a target on the basis of the plurality of X-ray fluoroscopic images acquired in each direction.02-16-2012
20130204067Method and Apparatus Pertaining to the Optimization of Radiation-Treatment Plans Using Automatic Changes to Treatment Objectives - Optimization of a radiation-delivery treatment plan can be facilitated by permitting the making of automatic changes to one or more treatment objectives. This can comprise processing radiation-delivery treatment plan parameters with respect to one or more predetermined treatment objectives and then automatically changing that predetermined treatment objective to provide one or more changed treatment objectives (including altered, deleted, and/or added treatment objectives) that can then be used to at least attempt to optimize a radiation-delivery treatment plan. That predetermined treatment objective can comprise, for example, a treatment objective as regards a given treatment volume. The automatic changing of the predetermined treatment objective can occur in response to a variety of stimuli such as detecting a change with respect to a treatment condition such as a change in the presentation of a patient volume of interest.08-08-2013
20130204068Apparatus and Methods For Treating Pulmonary Hypertension - A method is described for decreasing activity of at least one sympathetic nerve, nerve fiber or neuron innervating at least one blood vessel in the pulmonary vasculature of a patient to ameliorate pulmonary hypertension. In one embodiment, the method may involve advancing an intravascular treatment device to a target location in a target blood vessel within the pulmonary vasculature of the patient and using the treatment device to decrease activity of at least one sympathetic nerve, nerve fiber or neuron innervating the target blood vessel at or near the target location to ameliorate pulmonary hypertension.08-08-2013
20130204069Compositions and Methods of Treating Tumors - Methods of treating an individual who has an erbB protein mediated tumor is disclosed. Methods of preventing erbB protein mediated tumors in an individual are disclosed. The methods comprise administering to the individual a nucleic acid molecule that encodes a protein that dimerizes with an erbB protein and that is deficient in tyrosine kinase activity. Composition that comprise such nucleic acid molecules including pharmaceutical compositions are disclosed.08-08-2013
20120095277Methods and compositions for inhibition of multi-drug resistance by hyaluronan oligomers - Pharmaceutical compositions and methods for sensitizing multi-drug resistant cancer or radiation resistant cancer cells to chemotherapeutic agents are provided. Compositions include ligands of hyaluronan receptors, including glycosaminoglycans such as hyaluronan oligomers and derivatives of these oligomers, hyaluronan binding proteins, antibodies specific for hyaluronan receptors, hyaluronan mimetics, inhibitors of hyaluronan synthesis, and stimulators of hyaluronan degradation.04-19-2012

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