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Visible light radiation

Subclass of:

600 - Surgery

600300000 - DIAGNOSTIC TESTING

600407000 - Detecting nuclear, electromagnetic, or ultrasonic radiation

Patent class list (only not empty are listed)

Deeper subclasses:

Class / Patent application numberDescriptionNumber of patent applications / Date published
600478000 Light conducting fiber inserted into a body 98
600479000 Cardiovascular testing 74
600477000 With comparison means (e.g., ratio of or comparison to a standard) 40
Entries
DocumentTitleDate
20110201940Renal Function Analysis Method and Apparatus - A method for measuring a glomerular filtration rate of a mammalian subject comprises a source of reporter and marker fluorescent molecules. The fluorescent molecules are introduced into the vascular system of the mammalian subject. Over a period of time, a measurement of the intensities of the reporter and marker fluorescent molecules is taken. A ratio is calculated to determine the glomerular filtration rate.08-18-2011
20130030305METHOD AND SYSTEM FOR DETERMINING A STAGE OF FIBROSIS IN A LIVER - A method for determining a stage of fibrosis in a liver is disclosed. The method comprises the steps of: (1a) obtaining input data relating to the liver, the input data being generated using a second harmonic generation based imaging system; (1b) identifying a plurality of morphological features of the liver from the input data relating to the liver; (1c) generating a plurality of measurements based on the identified plurality of morphological features; and (1d) determining the stage of fibrosis in the liver based, on the generated plurality of measurements.01-31-2013
20100160790WEARABLE PHOTOACOUSTIC VASCULAR IMAGING SYSTEM - A non-invasive wearable imaging apparatus for vascular detection employing photo-acoustic principle is disclosed. Additionally, a wearable micro-display component is also described. The method includes pulsed laser as an energy source at a wavelength range at which both the blood and the adjoining tissue absorb the light and convert the energy into kinetic energy which heats the tissue. The temperature of the tissue rises and falls in sympathy with the frequency of the impinging light. The alternative heating and cooling of the illuminated region causes alternating sympathetic expansion and contraction of the region with corresponding rising and falling of the tissue surface and of the air in contact with the surface, thereby generating sound waves. A sensor enables the differentiation between the venous and surrounding tissues from which imaging of the venous tissue is extracted. In addition to the acoustic sensors, the sympathetic rising and falling of the tissue surface are converted into color characteristic signals representative of the relative displacement of the tissue surface. Additionally, the differential heating of the tissues enables the visual detection of the venous tissues by appropriate filter lenses. These embodiments also present miniaturization of the generation, imaging and display components, enabling the detection of the blood vessels in a wearable form factor.06-24-2010
20130046184METHOD OF ANALYZING AND PROCESSING SIGNALS - A physiological measurement system is disclosed which can take a pulse oximetry signal such as a photoplethysmogram from a patient and then analyse the signal to measure physiological parameters including respiration, pulse, oxygen saturation and movement. The system comprises a pulse oximeter which includes a light emitting device and a photodetector attachable to a subject to obtain a pulse oximetry signal; analogue to digital converter means arranged to convert said pulse oximetry signal into a digital pulse oximetry signal; signal processing means suitable to receive said digital pulse oximetry signal and arranged to decompose that signal by wavelet transform means; feature extraction means arranged to derive physiological information from the decomposed signal; an analyser component arranged to collect information from the feature extraction means; and data output means arranged in communication with the analyser component.02-21-2013
20090221920LOW-COHERENCE INTERFEROMETRY AND OPTICAL COHERENCE TOMOGRAPHY FOR IMAGE-GUIDED SURGICAL TREATMENT OF SOLID TUMORS - A method of forming an image of tissue. The method includes beginning an invasive procedure on a patient exposing tissue. The method then includes acquiring OCT data from the exposed tissue and converting the OCT data into at least one image. The method also includes ending the invasive procedure after the converting of the data.09-03-2009
20110196241DEVICE FOR DIAGNOSIS AND/OR THERAPY OF PHYSIOLOGICAL CHARACTERISTICS OF A SELECTED PORTION OF A BODY BY OPTICAL REFLECTANCE OR OPTICAL TRANSMISSION - The invention relates to a device for diagnosis and/or therapy of a selected portion of a body by optical reflectance or optical transmission. The device according to the invention has a laminar body (08-11-2011
20110196240IMAGE PROCESSING APPARATUS, IMAGE PROCESSING METHOD, IMAGE PROCESSING PROGRAM AND ELECTRONIC APPARATUS - Disclosed herein is an image processing apparatus for extracting a characteristic point from an image, the image processing apparatus including: a first light radiation section; a second light radiation section; an image taking section; a skin-area detection section; and a characteristic-point extraction section.08-11-2011
20110196239Systems, devices, and methods for detection of malaria - Systems, devices, and methods are described for providing a monitor or treatment device configured to, for example, detect hemozoin, as well as to monitor or treat a malarial infection.08-11-2011
20100081939Technique of mapping sentinel lymph nodes using organic blue dyes combined with fluorescence imaging - This invention pertains to a combined technique using an organic blue dye and fluorescence imaging to map sentinel lymph nodes. The near-infrared fluorescence emitted by the blue dye is displayed by a fluorescent imaging system after being irradiated by an excitation light whose wavelength is no less than 570 nm. The blue dye is one of methylene blue, Evans blue, isosulfan blue, patent blue, or a combination of them. The invention solves the problem that a comparatively large incision on skin is inevitable when traditional method is used to detect tumors for sentinel lymph node mapping. The technique of this invention for mapping the sentinel lymph nodes eliminates the need for surgical management, since the sentinel lymph nodes in deep tissue are observed directly through the near-infrared fluorescence of the blue dye reducing pain of the patient. It is a non-radiation, convenient, fast, and accurate method with high clinical values.04-01-2010
20100076319Pathlength-Corrected Medical Spectroscopy - Systems and methods for reducing scattering effects and correcting for patient to patient anatomical variability are provided. The scattering coefficient of an individual patient's tissue may be corrected for by examining the DC light levels of light passing through the tissue. By comparing the intensity of the light leaving the emitter with the light that reaches the detector to generate a DC component of the signal, which is representative of the anatomical structures of a patient, the AC component of the light may be corrected for the scattering coefficient of the tissue. By correcting the AC signal to account for the scattering coefficient of an individual patient's tissue, a medical sensor may be calibrated in situ for every patient.03-25-2010
20130085397OPTICAL FIBER INSTRUMENT SYSTEM AND METHOD WITH MOTION-BASED ADJUSTMENT - An instrument system that includes an optical fiber and a controller is provided. The optical fiber is coupled to an external structure of a patient and has a strain sensor provided thereon. The controller is operatively coupled to the optical fiber and adapted to receive a signal from the strain sensor and to determine a property of respiration of the patient based on the signal.04-04-2013
20130079644Optical Probe with Electric Motor - Optical probes may be used to capture images of a subject. An optical probe may include an optical reflector, an optical waveguide, and an electric motor. A rotor of the electric motor is mechanically coupled with the optical reflector to rotate the optical reflector in response to an input electric current. The optical waveguide is optically coupled with the optical reflector. The optical waveguide may output light to the optical reflector which directs the light to the subject. Light may then reflect back from the subject to the optical reflector which directs the reflected light from the subject to the optical waveguide.03-28-2013
20100036261METHOD AND DEVICE FOR IMAGE GUIDED SURGERY - A fluorometer includes a light source to generate excitatory light toward a tissue, the tissue generating fluorescent light in response to the excitatory light. The fluorometer also includes a light sensor to receive the fluorescent light and generate a digital signal. A processor is connected to the light sensor to receive the digital signal and generate a digital image, and a display displays the digital image. The tissue generates fluorescent light as a result of excitation of at least one intrinsic tissue metabolic product. A method for distinguishing between viable and non-viable tissue using the fluorometer also is described.02-11-2010
20130137991HANDHELD SKIN MEASURING OR MONITORING DEVICE - A handheld skin monitoring or measuring device includes a camera having a camera optical axis; and a structured light arrangement configured to project three or more laser fan beams such that the laser fan beams cross at a crossing point in front of the camera.05-30-2013
20130035598IMAGING DEVICE FOR USE WITH A SURGICAL DEVICE - a surgical imaging device is provided, including a housing configured to couple to an outer surface of a surgical device and an image capture arrangement configured to generate image data; the surgical imaging device may also include a circuit arrangement disposed within the housing and electrically coupled to the camera arrangement, in which the circuit arrangement is configured to communicate the image data to at least one remote device.02-07-2013
20100145199Cancer Detection System - A cancer detection system (06-10-2010
20100145200SPATIALLY OFFSET RAMAN SPECTROSCOPY OF LAYERED SOFT TISSUES AND APPLICATIONS OF SAME - The present invention in one aspect relates to a method for surgical margin evaluation of tissues during breast conserving therapy at a surgical site of interest. In one embodiment, the method comprises the steps of acquiring a plurality of spatially offset Raman spectra from the surgical site of interest, identifying tissue signatures from the plurality of spatially offset Raman spectra, and determining surgical margins of the surgical site from the identified tissue signatures.06-10-2010
20130035599RESPIRATORY MOTION DETECTION APPARATUS - The invention relates to a respiratory motion detection apparatus (02-07-2013
20100042005DETECTING OPTICAL PROPERTIES OF A TURBID MEDIUM - A device for measuring light scattering and absorption properties of a tissue, the device comprising: a probe comprising first and second optical fibers for irradiation and detection. The optical fibers are substantially parallel to each other at the distal end, and are separated by a distance of less than 2 mm, wherein said first and second optical fibers are arranged in said probe at an angle, 6=10 deg. to 45 deg., to the plane perpendicular to the distal end of said probe and wherein the tips of the optical fibers at the distal end are polished parallel to the plane perpendicular to the distal end of said probe.02-18-2010
20100042003SMALL-SCALE DIAGNOSTIC SYSTEM AND DISPLAY CONTROL METHOD - A small-scale diagnostic system and a display control method are provided. In the diagnostic system while image data on a patient is displayed on a screen of a medical image control device, when image data on another patient is received from an image generating device, and the medical doctor wants to display the received image data on the another patient on the screen for examining the image and diagnosing the another patient, the displayed image on the screen can be switched to that of the image data on the another patient by a simple operation of depressing a patient selection button. This enables the medical doctor to perform image diagnosis efficiently in a small-scale facility such as a clinic.02-18-2010
20100042002THREE-DIMENSIONAL IMAGING USING AN INFLATABLE MEMBRANE - The attenuation and other optical properties of a medium are exploited to measure a thickness of the medium between a sensor and a target surface. Disclosed herein are various mediums, arrangements of hardware, and processing techniques that can be used to capture these thickness measurements and obtain three-dimensional images of the target surface in a variety of imaging contexts. This includes general techniques for imaging interior/concave surfaces as well as exterior/convex surfaces, as well as specific adaptations of these techniques to imaging ear canals, human dentition, and so forth.02-18-2010
20100042001Raman Instrument for Measuring Weak Signals in the Presence of Strong Background Fluorescence - A method for measuring a chemical concentration in tissue has two measurement steps. A portion of tissue is illuminated with a first generated light and a second generated light. A first Raman scattered light, corresponding to the first generated light, and a second Raman scattered light, corresponding to the second generated light, are directed to a plurality of light sensors, each light sensor measuring light at a different wavelength, that wavelength being proximate to a wavelength of an expected Raman shift wavelength for the chemical in the tissue. A measurement is obtained from each light sensor, each measurement being specific to the first scattered light and/or the second reflected light to that light sensor. The measurements of the first scattered light and the measurements of the second scattered light are used to calculate a concentration of the chemical in the tissue.02-18-2010
20100042000Method for correcting the image data that represent the blood flow - A method for correcting the image data representing the blood flow for the evaluation and quantitative representation of the blood flow in a tissue or vascular region is based on the signal of a contrast agent injected into the blood. Several individual images of the signal emitted by the tissue or vascular region are recorded and stored at successive points in time. At least two individual images are correlated and a shift vector is generated based on the correlation. Thereafter, the image data of the individual images are shifted in relation to each other according to the shift vector.02-18-2010
20100041999Process for quantitative display of blood flow - A method for the quantitative representation of the blood flow in a tissue or vascular region based on the signal of a contrast agent injected into the blood. In the process, several individual images of the signal emitted by the tissue or vascular region are recorded at successive points in time and are stored. For image areas of stored individual images the respective point in time is determined at which the signal has exceeded a certain threshold value and this point in time is represented for each of the image areas.02-18-2010
20100106025METHODS FOR OPTICAL IDENTIFICATION AND CHARACTERIZATION OF ABNORMAL TISSUE AND CELLS - An optical system and apparatus for the diagnosis of a biological sample is disclosed. An embodiment of the apparatus includes an optical probe, a probe head distally connectable to the optical probe, the optical probe further comprising at least one optical element for applying an electromagnetic radiation of a first wavelength to the biological sample, and one or more collection elements positioned proximate the at least one optical element; and an analyzer for analyzing a signal received from the biological sample by the one or more collection elements.04-29-2010
20100106026OPTICAL IMAGING OF INDUCED SIGNALS IN VIVO UNDER AMBIENT LIGHT CONDITIONS - A method for detecting and localizing a target tissue within the body in the presence of ambient light in which an optical contrast agent is administered and allowed to become functionally localized within a contrast-labeled target tissue to be diagnosed. A light source is optically coupled to a tissue region potentially containing the contrast-labeled target tissue. A gated light detector is optically coupled to the tissue region and arranged to detect light substantially enriched in target signal as compared to ambient light, where the target signal is light that has passed into the contrast-labeled tissue region and been modified by the contrast agent. A computer receives signals form the detector, and passes these signals to memory for accumulation and storage, and then to image processing engine for determination of the localization and distribution of the contrast agent. The computer also provides an output signal based upon the localization and distribution of the contrast agent, allowing trace amounts of the target tissue to be detected, located, or images. A system for carrying out the method is also described.04-29-2010
20100106024Method for diagnosing vulvovaginal disorders - A method for diagnosing the presence of a vulvovaginal disorder is provided. The method uses a source of cross-polarized light to detect subsurface irritation in the vulvovaginal area. The presence of subsurface irritation is then used to diagnose the presence of a vulvovaginal disorder.04-29-2010
20130041267METHOD AND DEVICE FOR MULTI-SPECTRAL PHOTONIC IMAGING - An imaging device for medical imaging includes a light source device arranged to illuminate a sample under investigation with illumination light, a detector device arranged to collect a plurality of images including at least two sample light images backscattered by the sample in different spectral ranges, and at least one marker light image originating from at least one marker substance in the sample, and a processor device adapted to process the at least two sample light images and create at least one correction component, the processor device further adapted to correct the marker light image using the at least one correction component.02-14-2013
20090124909Medical system and method for visualizing regions being monitored in a medical system - The invention relates to a medical diagnostic or therapy system comprising a system controller and at least one moving apparatus component, comprising a contour detecting unit which is constructed for detecting the position of components of the diagnostic or therapy system, and at least one projector that is decoupled from the contour detecting unit and is constructed for visualizing the region being monitored in which the component of the diagnostic and/or therapy system scanned by the contour detecting unit is arranged. The invention also relates to a method for visualizing regions being monitored in a medical diagnostic or therapy system of this kind.05-14-2009
20120184857OPHTHALMIC LASER TREATMENT APPARATUS - An ophthalmic laser treatment apparatus comprises: a main unit; a laser source; a hand-held cabinet; a laser delivery optical system for irradiating the laser beam in a predetermined irradiation pattern onto tissues of the patient's eye, the laser delivery optical system including: a fiber unit connecting the hand-held cabinet to the main unit; a scanner for deflecting an optical axis of the laser beam; and an image forming optical system for forming an image of the laser beam in the form of a spot on the tissues of the patient's eye; an irradiation pattern setting unit for setting an irradiation pattern of the treatment laser beam; a control unit for controlling drive of the scanner; and a beam combiner provided in the hand-held cabinet to make an observation optical path and an optical path of the laser delivery optical system coincident with each other.07-19-2012
20130046186METHOD OF ANALYZING AND PROCESSING SIGNALS - A physiological measurement system is disclosed which can take a pulse oximetry signal such as a photoplethysmogram from a patient and then analyse the signal to measure physiological parameters including respiration, pulse, oxygen saturation and movement. The system comprises a pulse oximeter which includes a light emitting device and a photodetector attachable to a subject to obtain a pulse oximetry signal; analogue to digital converter means arranged to convert said pulse oximetry signal into a digital pulse oximetry signal; signal processing means suitable to receive said digital pulse oximetry signal and arranged to decompose that signal by wavelet transform means; feature extraction means arranged to derive physiological information from the decomposed signal; an analyser component arranged to collect information from the feature extraction means; and data output means arranged in communication with the analyser component.02-21-2013
20130046185METHOD OF ANALYZING AND PROCESSING SIGNALS - A physiological measurement system is disclosed which can take a pulse oximetry signal such as a photoplethysmogram from a patient and then analyse the signal to measure physiological parameters including respiration, pulse, oxygen saturation and movement. The system comprises a pulse oximeter which includes a light emitting device and a photodetector attachable to a subject to obtain a pulse oximetry signal; analogue to digital converter means arranged to convert said pulse oximetry signal into a digital pulse oximetry signal; signal processing means suitable to receive said digital pulse oximetry signal and arranged to decompose that signal by wavelet transform means; feature extraction means arranged to derive physiological information from the decomposed signal; an analyser component arranged to collect information from the feature extraction means; and data output means arranged in communication with the analyser component.02-21-2013
20130046183WEARABLE VISION DEVICE - The present invention aims to provide alternative means for the diagnosis of the risk of developing mouth mucosa cancers by means of fluorescence, easy to use, simple, light and space-saving and diagnostic kits comprising the above-mentioned device.02-21-2013
20090306519MEASUREMENT WITH MULTIPLEXED DETECTION - The invention relates to a device (12-10-2009
20090306520Quantitative methods for obtaining tissue characteristics from optical coherence tomography images - A method and apparatus for determining properties of a tissue or tissues imaged by optical coherence tomography (OCT). In one embodiment the backscatter and attenuation of the OCT optical beam is measured and based on these measurements and indicium such as color is assigned for each portion of the image corresponding to the specific value of the backscatter and attenuation for that portion. The image is then displayed with the indicia and a user can then determine the tissue characteristics. In an alternative embodiment the tissue characteristics is classified automatically by a program given the combination of backscatter and attenuation values.12-10-2009
20090093728Vasculature and lymphatic system imaging and ablation associated with a reservoir - Devices, methods, and systems related to imaging and ablation are disclosed.04-09-2009
20090093727BIOIMAGING APPARATUS - To improve image quality as well as considering miniaturization. In the top surface 04-09-2009
20130072803SKIN OPTICAL CHARACTERIZATION DEVICE - The present invention is generally directed to dermatological devices and methods in which one or more skin characteristics, such as the melanin index, are determined by analyzing radiation backscattered from a skin region illuminated by at least one, and preferably, two or more wavelengths, e.g., in a range of about 600 nm to about 900 nm. In many embodiments, the radiation is coupled to the skin via a waveguide, and an optical sensor is employed to ascertain contact between the waveguide (e.g., a waveguide surface adapted for contact with the skin) and the skin.03-21-2013
20130072804LIGHT TRANSMITTING PROBE, LIGHT RECEIVING PROBE, LIGHT TRANSMITTING AND RECEIVING PROBE, AND LIGHT MEASUREMENT DEVICE USING SAME - A light transmitting probe comprising: a housing for fixing the probe to a mounting portion of a holder to be mounted on a subject; a light emitter for emitting light, the light emitter being placed in an end portion of the housing; and a transmission channel, one end of which is connected to the light emitter, and the other end of each is connected to a controller; the light transmitting probe irradiating the subject with light when fixed to the holder, and being characterized in that the end portion of the housing has a number of rod-shaped protrusions, the light emitter is a number of light emitting elements, the light emitting elements are respectively placed in an end portion of each protrusion, the transmission channel is a number of transmission channels, and the transmission channels are respectively placed inside each protrusion.03-21-2013
20130060146SYSTEM AND METHODS FOR INTRAOPERATIVE GUIDANCE FEEDBACK - Systems and methods for surgical guidance and image registration are provided, in which three-dimensional image data associated with an object or patient is registered to topological image data obtained using a surface topology imaging device. The surface topology imaging device may be rigidly attached to an optical position measurement system that also tracks fiducial markers on a movable instrument. The instrument may be registered to the topological image data, such that the topological image data and the movable instrument are registered to the three-dimensional image data. The three-dimensional image data may be CT or MRI data associated with a patient. The system may also co-register images pertaining to a surgical plan with the three-dimensional image data. In another aspect, the surface topology imaging device may be configured to directly track fiducial markers on a movable instrument. The fiducial markers may be tracked according to surface texture.03-07-2013
20080294056BISPECTRAL PEROPERATIVE OPTICAL PROBE - The general field of the invention is that of peroperative optical probes designed to assist surgeons in performing medical procedures. The optical probes of the fluorescence type according to the invention are designed to be used on living tissues where the diseased areas have been marked by a fluorescent marker. They have dual lighting. The first situated in the red or near-infrared spectrum is necessary for achieving the fluorescence of the marked areas and for obtaining an image exploitable by a camera. The second situated in the visible spectrum is necessary for illuminating the marked areas with visible light, thus making the surgeon's work easier. The visible lighting can be punctiform or can be provided by an image projector. In the latter case, the projected image illuminates only the diseased areas.11-27-2008
20090270738Methods for single-pass volumetric bidirectional blood flow imaging Spectral Domain Optical Coherence Tomography using a modified hilbert transform - The present subject matter relates to in vivo volumetric bidirectional blood flow imaging using single-pass flow imaging spectral domain optical coherence tomography. This technique uses a modified Hilbert transform algorithm to separate moving and non-moving scatterers within a depth. The resulting reconstructed image maps the components of moving scatterers flowing into and out of the imaging axis onto opposite image halfplanes, enabling volumetric bidirectional flow mapping without manual segmentation.10-29-2009
20130066214HOLDER AND LIGHT MEASURING DEVICE USING SAME - Provided is a holder which comprises at least two probe mount portions and is to be put on the head of a subject by inserting a light-transmitting probe for emitting light from the tip thereof or a light-receiving probe for receiving light through the tip thereof in the probe mount portion, the holder characterized by being provided with a linear backbone portion extending in a first direction, at least two linear branch portions extending in a second direction different from the first direction, and a disposition reference point disposed so as to match a first specific point, the first specific point being set in the head of the subject.03-14-2013
20120116233SENSOR SYSTEM - A sensor system adapted for characterizing a region of interest within a subject while minimizing bleeding is provided. The sensor system comprises a hollow tool configured to be inserted into the subject, the hollow tool comprising an orifice positioned at an angle with respect to its horizontal axis, a probe disposed within the hollow tool and configured to transmit data from the region of interest; wherein the probe protrudes from the orifice of the hollow tool to be in contact with the region of interest and processing circuitry coupled to the probe and configured to process the sensed data to characterize the region of interest.05-10-2012
20120116232METHOD FOR DETERMINATION OF UNKNOWN MUTATIONS - The present invention relates to a method of using Raman spectra to identify unknown mutations in a gene, more specifically the filaggrin gene. Specifically, the present invention relates to a method to determine if a person has a homozygous or compound heterozygous mutation in the filaggrin-gene comprising measurement of the presence of tyrosine in the skin. Preferably said measurements are performed by Rama spectrography and on the tsiie of the skin, most preferably on the palm of the hand. Further, when these measurements are taken together with measurements of the NMF content of the skin it, the present invention relates to a method of classifying atopic dermatitis.05-10-2012
20090054790Method and Arrangement for Generating a Signal which Corresponds to the Degree of Opening of the Vocal Folds of the Larynx - The invention relates to a method for generating a signal which corresponds to the degree of opening of the vocal folds of the larynx, in which the vocal folds are illuminated by means of a light source and are optically observed by means of an endoscope and a signal which is modulated by the movement of the vocal folds, the vocal fold signal, is displayed and/or recorded, wherein the vocal folds are illuminated with light having a wavelength greater than 600 nm or with red light, and wherein the light which is modulated by the movement of the vocal folds, the vocal fold light, is received by a sensor and is detected in order to generate a vocal fold signal which can be visualised, and visible light which contains little infrared or red light is used at the same time to observe the vocal folds.02-26-2009
20090012404Electronically Scanned Optical Coherence Tomography With Frequency Modulated Signals - An improved Optical Coherence Domain Reflectometry (OCDR) system is provided. One embodiment of this OCDR system outputs a detector signal carrying image depth information on multiple modulation frequencies, where each modulation frequency corresponds to a different image depth. The image depth information from the detector signal may be resolved by tuning to the desired modulation frequency. Another system for imaging body tissue uses multiple frequency modulators such that the light beam does not travel from an optical fiber to free space.01-08-2009
20130165798DETECTING OPTICAL PROPERTIES OF A TURBID MEDIUM - Disclosed herein are methods and devices for evaluating the optical properties of a turbid medium, wherein the medium is one which both absorbs and scatters light. Turbid media of particular interest include fluids such as coolants, paints, etc., and biologically or medically relevant fluids, such as blood, culture media, etc. The methods and devices disclosed herein can also be used to measure changes in optical properties of a tissue (e.g., an epithelial layer) that are associated with a variety of disease states. Changes or differences in the optical properties of tissue can provide indicia of a pathological state or the efficacy of a therapeutic regimen. In general, the change or difference can be a change or difference relative to a standard that is either internal or external. Also disclosed herein are methods for obtaining absolute values for optical properties that are generally obtained as relative values. This absolute value can be compared effectively with an absolute value from another sample with meaningful results.06-27-2013
20100087739APPARATUS FOR OPTICAL BODY ANALYSIS - An apparatus for optical body analysis is built with an illumination and detection head, and an optical coupler. The illumination and detection head comprises a light source for illuminating a body portion to analyze through the optical coupler and a detector for receiving light diffusely reflected by the body portion. The optical coupler is mechanically decoupled from the illumination and detection head and is adapted to be in contact with an outer surface of the body portion while the contact between the optical coupler and the body portion minimally affects physical properties of the body portion. The apparatus may further comprise a position unit adapted to adjust the position of the illumination and detection head relative to the optical coupler so that the detector receives through the optical coupler light generated by the light source and diffusely reflected by the body portion.04-08-2010
20100087740COLON POLYP STAGING METHODS - Systems and methods are provided for examination and removal of polyps. Using methods and systems of the present disclosure, one can determine whether a polyp is benign or cancerous in situ.04-08-2010
20120238883OPTICAL MEASUREMENT SYSTEM, PORTABLE OPTICAL MEASUREMENT DEVICE USED THEREIN, AND REHABILITATION PLANNING METHOD USING SAME - An optical measurement system having a main and a portable optical measurement devices. The portable optical measurement device is provided with a second case portable by the subject, C second light sending means for illuminating the subject, D second light receiving means receiving light emitted from the subject, a second holder worn on the head of the subject and having at least (C+D) through holes therein, a control unit acquiring measurement data relating to a brain activity while controlling the second light sending and receiving means, and a communication unit communicating with the main optical measurement device, that (C+D)>(A+B) is satisfied, and that the communication unit of the portable optical measurement device transmits the measurement data acquired by the control unit of the portable optical measurement device to the main optical measurement device.09-20-2012
20120238882SKIN OPTICAL DIAGNOSING APPARATUS AND OPERATING METHOD THEREOF - A skin optical diagnosing apparatus and operating method thereof are disclosed. The skin optical diagnosing apparatus includes a positioning module, an optical sensing module, a processing module, and a display module. The skin optical diagnosing apparatus uses the positioning module to select a target region on a sample, and then the optical sensing module performs an optical sensing on the target region to obtain an optical information data related to the target region. The processing module is used for processing the optical information data to generate an optical diagnosed result. The display module is used for displaying the optical diagnosed result.09-20-2012
20120238881ORAL OPTICAL DIAGNOSING APPARATUS AND OPERATING METHOD THEREOF - An oral optical diagnosing apparatus and operating method are disclosed. The oral optical diagnosing apparatus includes a positioning module, an optical sensing module, a processing module, and a display module. After the positioning module selects a region to be diagnosed in a mouth, the optical sensing module will perform optical sensing on the region to be diagnosed to obtain optical information related to the region to be diagnosed. The processing module is used to analyze the optical information to generate an optical diagnosed result. The display module is used to display the optical diagnosed result.09-20-2012
20120271176METHOD AND SYSTEM FOR OPTICALLY EVALUATING PROXIMITY TO THE INFERIOR ALVEOLAR NERVE IN SITU - A low coherence interferometry probe system for evaluating proximity to a tissue layer, comprising a low coherence light source, an excitation optical fiber to bring the low coherence excitation light near the tissue layer and a collection optical fiber for capturing back-scattered light from the tissue layer. The probe system comprises an interferometry sub-system and a processor for evaluating a distance to the tissue layer. There is also provided a spectral absorption probe system for evaluating proximity to an artery, comprising a light source excitation light having a wavelength adapted for absorption by blood chromophores, an excitation optical fiber and a collection optical fiber. The probe system comprises a light detector and a processor for determining a distance to the artery using the Beer-Lambert law of light absorption with a value for surrounding tissue attenuation coefficient (μeff). A probe system combining low coherence interferometry and spectral absorption is also provided.10-25-2012
20090204009MEDICAL DEVICE SYSTEM AND RELATED METHODS FOR DIAGNOSING ABNORMAL MEDICAL CONDITIONS BASED ON IN-VIVO OPTICAL PROPERTIES OF TISSUE - A diagnostic system detects abnormal physical properties of tissue in a patient based upon optical properties of the tissue. A probe includes light delivery and capture fibers, and polarizers. Optical properties detected relate to polarized and unpolarized light into, and scattering from, the tissue. The optical properties detected are processed and analyzed to produce results indicative of the physical property(s) evaluated. System operation is controlled against pressure monitored via a pressure sensor coupled to the probe-tissue interface. The analysis corrects for patient physical characteristics as user inputs, such as menopausal or menstrual condition of women patients. Physical properties diagnosed include cervical dysplasia conditions in women patients, such as HSIL, cervical cancer, LSIL, or cervicitis. Analysis and diagnosis is based upon at least one of: ratios between scattered light signals captured from the tissue, slope of intensity over wavelength for scattered light signals captured, and hemoglobin-related parameters in the tissue.08-13-2009
20100094135SYSTEMS AND METHODS FOR PHASE MEASUREMENTS - Preferred embodiments of the present invention are directed to systems for phase measurement which address the problem of phase noise using combinations of a number of strategies including, but not limited to, common-path interferometry, phase referencing, active stabilization and differential measurement. Embodiment are directed to optical devices for imaging small biological objects with light. These embodiments can be applied to the fields of, for example, cellular physiology and neuroscience. These preferred embodiments are based on principles of phase measurements and imaging technologies. The scientific motivation for using phase measurements and imaging technologies is derived from, for example, cellular biology at the sub-micron level which can include, without limitation, imaging origins of dysplasia, cellular communication, neuronal transmission and implementation of the genetic code. The structure and dynamics of sub-cellular constituents cannot be currently studied in their native state using the existing methods and technologies including, for example, x-ray and neutron scattering. In contrast, light based techniques with nanometer resolution enable the cellular machinery to be studied in its native state. Thus, preferred embodiments of the present invention include systems based on principles of interferometry and/or phase measurements and are used to study cellular physiology. These systems include principles of low coherence interferometry (LCI) using optical interferometers to measure phase, or light scattering spectroscopy (LSS) wherein interference within the cellular components themselves is used, or in the alternative the principles of LCI and LSS can be combined to result in systems of the present invention.04-15-2010
20110184293DEVICE, METHOD AND KIT FOR IN VIVO DETECTION OF A BIOMARKER - The invention relates to a device and a system for in-vivo detection of a biomarker in the gastrointestinal tract. The invention further relates to a method for the in-vivo detection of a biomarker in the gastrointestinal tract such as e.g., the α1-antitrypsin precursor (A1AT biomarker), by using the recognition factor, e.g., trypsin immobilized to a solid surface. The invention further relates to a kit for the in-vivo detection of a biomarker in the gastrointestinal system.07-28-2011
20100305452OPTICAL COHERENCE TOMOGRAPHY FOR BIOLOGICAL IMAGING - Described herein are catheters for use with Optical Coherence Tomography (OCT) that include an optical fiber core having a first refractive index and an interface medium having a second refractive index, where the first and second refractive indexes are mismatched such that receiving electronics configured to receive optical radiation reflected from the reference interface and the target operate in a total noise range that is within 5 dB of the shot noise limit. These OCT catheters may include a silicon die mirror having a reflective coating that is embedded in the interface medium. The optical fiber can be fixed at just the distal end of the catheter, and may be managed within a handle that is attached to the proximal end of the catheter body, and is configured to allow rotation of the both catheter body and the optical fiber relative to the handle.12-02-2010
20100016730EXAMINATION SYSTEM, REHABILITATION SYSTEM, AND VISUAL INFORMATION DISPLAY SYSTEM - In an examination system including a head mounted display having image pickup devices such as CCDs provided therein and a computer, coordinates of an image to be displayed in the head mounted display can be set object- or body-centered. An image captured by the image pickup device is supplied to the computer where it will be processed in a predetermined manner for display in the head mounted display.01-21-2010
20110282214Method for Determining the Condition of a Biological Object and Device for Making Same - The invention relates to the field of instrumentation and can be used for diagnosing the condition of a biological object. The technical result consists in an increased measurement precision. In order to achieve this result, the invention comprises determining the condition of a biological object on the basis of fixation and comparison of the structures of gas-discharge light emission around the reference object and the biological object under study in an electromagnetic field. The light emissions around the reference object and the biological object under study are converted into digital code. The invention comprises determining the quantitative parameters of the light emission and the characteristics thereof. The invention also comprises determining corresponding spatial points of specified parameters for the reference object and the biological object under study. The invention further comprises determining the deviation of quantitative parameters that characterize the condition of the biological object under study by means of the distance between said points. The reference object is implemented as a non-biological material. The invention also comprises carrying out the fixation of the structure of gas-discharge light emission around the reference object and determining the relative deviation thereof from an average value.11-17-2011
20110282213BIOLOGICAL OBSERVATION APPARATUS - Tumor tissue or the like that exists at a deep portion of a living organism far from an internal wall of a body cavity is observed. A biological observation apparatus (11-17-2011
20100217129ANGIOGENESIS MONITORING USING IN VIVO HYPERSPECTRAL RADIOMETRIC IMAGING - This invention relates to the use of in-vivo hyperspectral imaging to monitor angiogenesis. Specifically, the invention provides systems and methods of obtaining hyperspectral images of a field of view comprising an area sought to be monitored.08-26-2010
20100234740Method and Apparatus for Evaluating Ocular Tissue Conditions - Methods and apparatus are provided for evaluating an ocular tissue condition of a patient (e.g., a disease, a risk of developing a disease, etc.). For example, an indicator associated with the ocular tissue condition may be generated. A portion of ocular tissue of the patient is irradiated using a light source. Light from the portion of the ocular tissue is received. Raman spectra information associated with the received light is determined. An indicator of an ocular tissue condition is generated based at least on the Raman spectra information. The indicator may, for example, assist a physician in diagnosing or ruling out the ocular tissue condition.09-16-2010
20090069696METHOD OF DIAGNOSING A LOWER URINARY TRACT DISORDER - A method for sensitively diagnosing lower urinary tract disorders, particularly interstitial cystitis, is provided. The method can visually, simply, and clearly diagnose bladder ulcer without requirement of bladder hydrodistention under anesthesia. In the method, lower urinary tract disorders are diagnosed by observing an abnormality of a blood vessel and/or a newly formed blood vessel in a surface of bladder mucous membrane among abnormalities in blood vessels and/or newly formed blood vessels by visually comparing an image of the surface of the bladder mucous membrane and an image of a deep portion of the bladder mucous membrane obtained using a bladder endoscope system having a narrow band imaging device.03-12-2009
20120010513Chemically-selective, label free, microendoscopic system based on coherent anti-stokes raman scattering and microelectromechanical fiber optic probe - An endoscopic microscopic system for collecting and processing a sequence of images.01-12-2012
20110137179DIFFERENTIAL LASER-INDUCED PERTURBATION (DLIP) FOR BIOIMAGING AND CHEMICAL SENSING - Methods for imaging or optical sensing of a material are provided. A first fluorescent image or optical signal of a material can be recorded, the material can be perturbed, and then a second fluorescent image or optical signal of the material can be recorded. The two fluorescent images or signals can be subtracted to give a differential image or optical signal.06-09-2011
20100249610Modular headrest and multi-light apparatus - A multi-light apparatus (09-30-2010
20100249609MEASUREMENT OF NEURAL FUNCTIONALITY USING PHASE SENSITIVE OPTICAL COHERENCE REFLECTOMETRY - Optical methods, devices, and systems for noninvasively detecting transient surface displacements in a neuron are disclosed. Methods, devices, and systems provided may employ a phase-sensitive optical low coherence reflectometer. In addition, surface displacements due to action potential propagation in neural tissues may be detected in some embodiments using back-reflected light. According to some embodiments, exogenous chemicals or reflect ion coatings are not required. Transient neural surface displacement of less then 1 nm in amplitude and 1 ms in duration may be detected and may be generally coincident with action potential arrival to the optical measurement site. The systems and methods may be used for noninvasive detection of various neuropathies such as retinal neuropathies. They may also be useful in detecting the effects of various pharmacological agents.09-30-2010
20100249608Optical examination device, system and method - As part of an examination device, an input or output optical coupler device for transmitting photons between an optical source or detector and an examined body part includes an array of optical fibers with end portions freely protruding as cantilevers from a support. The optical fibers have the end portions fabricated, sized and distributed to penetrate freely extending hair when the support is placed on the head or other surface of a subject to make optical contact directly over an array of points with the surface of the scalp or skin below the free hair.09-30-2010
20100249607QUANTITATIVE SPECTROSCOPIC IMAGING - The present invention relates to a fully quantitative spectroscopy imaging instrument for wide area detection of early cancer (dysplasia). This instrument provides quantitative maps of tissue biochemistry and morphology, making it a powerful surveillance tool for objective early cancer detection. The design, construction, calibration, and diagnostics applications of this system is described with the use of physical tissue models. Measurements were conducted on a resected colon adenoma, and the system can be used for vivo imaging in the oral cavity.09-30-2010
20090292211Methods and Apparatus for Optical Spectroscopic Detection of Cell and Tissue Death - A method for detecting death process of a cell or tissue of a living subject. In one embodiment, the method includes the steps of illuminating the cell or tissue of the living subject with a coherent light, collecting fluorescent light returned from the illuminated cell or tissue of the living subject, identifying a NAD(P)H peak of a spectrum of the collected fluorescent light with a wavelength, λ11-26-2009
20110295125Apparatus and method for radio frequency ablation of a liver tumor in liver tissues - A method for detecting death process of a cell or tissue of a living subject. In one embodiment, the method includes the steps of illuminating the cell or tissue of the living subject with a coherent light, collecting fluorescent light returned from the illuminated cell or tissue of the living subject, identifying a NAD(P)H peak of a spectrum of the collected fluorescent light with a wavelength, λ12-01-2011
20120190989DISTRIBUTED EXTERNAL AND INTERNAL WIRELESS SENSOR SYSTEMS FOR CHARACTERIZATION OF SURFACE AND SUBSURFACE BIOMEDICAL STRUCTURE AND CONDITION - Systems and methods are disclosed that use wireless coupling of energy for operation of both external and internal devices, including external sensor arrays and implantable devices. The signals conveyed may be electronic, optical, acoustic, biomechanical, and others to provide in situ sensing and monitoring of internal anatomies and implants using a wireless, biocompatible electromagnetic powered sensor systems.07-26-2012
20120089030SYSTEM AND METHOD FOR CHARACTERIZATION OF ORAL, SYSTEMIC AND MUCOSAL TISSUE UTILIZING RAMAN SPECTROSCOPY - A method and system for characterizing tissue includes a probe connected to a red LASER source and a Raman spectroscope. The probe includes at least excitation fiber and one or more emission fibers that connect the probe with the LASER source and the Raman spectroscope. The excitation fiber is connected to the red LASER source and terminates in the first end of the probe adjacent the tip of the probe. The emission fibers are connected to the Raman spectroscope and terminate in the first end of the probe adjacent the tip of the probe. In one embodiment, the excitation fiber extends through the central portion of the probe and one or more emission fibers are arranged around the excitation fiber. The tip of the probe is intended to come in contact with the tissue to be examined. The tip includes a central opening to allow red LASER radiation to project out of the end of the red excitation fiber on to the tissue and to permit Raman spectra to enter the emission fiber(s) and travel to the Raman spectroscope. The tip is constructed to have a predefined focal length to position the first end of the probe a predefined distance from the surface of the tissue being examined. The tip can be removable and tips having different focal lengths can be used to accommodate different types of tissues and examinations. A detector can convert the Raman spectra into signals and data for analysis by a computer system. The Raman spectra for tissue in a predefined location can be profiled such that the system can distinguish between healthy and diseased tissue.04-12-2012
20090036782SYSTEMS AND METHODS FOR PROVIDING BEAM SCAN PATTERNS FOR HIGH SPEED DOPPLER OPTICAL FREQUENCY DOMAIN IMAGING - An exemplary apparatus and/or an exemplary method can be provided using which, it is possible (e.g., with at least one first arrangement) to measure an amplitude and/or a phase of at least one electromagnetic radiation provided from a particular portion of a sample. Further, it is possible (e.g., using at least one second arrangement) to scan a location of the particular portion along a path from a first point of the sample to a second point of the sample. In addition, it is possible to control the scan (e.g., with the second arrangement) such that the scan may comprise at least one first segment having a positive velocity and at least one segment having a negative velocity. A first distance of the first segment and/or the second segment can be smaller than a second distance between the first and second points.02-05-2009
20100113940WOUND GOGGLES - Appropriate assessment of wound oxygenation is critical to establish a diagnosis, to monitor the effect of the treatment, to guide the therapeutic process, to identify the presence of infection, and to predict the treatment outcome. Embodied systems and methods represent an enabling technology for noninvasive and objective assessment of wound tissue oxygenation. In addition to wound healing, disclosed embodiments offer low cost and portable avenues for noninvasive assessment of multiple clinical parameters for the detection and intervention of various malignancies in multiple soft tissue systems.05-06-2010
20090069697ACTIVE MICRONEEDLES AND MICRONEEDLE ARRAYS - An active needle device for fluid injection or extraction includes at least one hollow elongated shaft defining at least one channel. The channel provides communication between at least one input port and at least one output port of the needle device. At least one active component such as a sensor or actuator is placed or integrated into the elongated shaft. The needle device can include a macroneedle, a microneedle, or an array of macroneedles or microneedles. The microneedles can be fabricated on a substrate which can remain attached to the microneedles or be subsequently removed. The active component can facilitate biochemical, optical, electrical, or physical measurements of a fluid injected or extracted by the needle device.03-12-2009
20090149761PHOTOACOUSTIC IMAGING METHOD - This invention discloses a method to position, identify and characterize a photoacoustic source in a complex environment. This method isolates individual acoustic responses from interferences by spectral analysis and filtering and locates primary acoustic sources by applying beam-forming to decomposed acoustic responses. The photon-absorbing structure of a tissue can be constructed with primary source parameters.06-11-2009
20100268090MEASUREMENT OF HEMATOCRIT AND CARDIAC OUTPUT FROM OPTICAL TRANSMISSION AND REFLECTION CHANGES - A system and method of non-invasive determination of hematocrit change from optical reflected light in combination with transmitted light or from reflected light measured from one or more locations on a blood carrying medium. Determining the cardiac output of a patient based on the amount of plasma or saline injected and the determined hematocrit change. The cardiac output may be determined on a patient undergoing hemodialysis. The hematocrit changes can be detected transcutaneously, transarterially, intraarterially, or across an extracorporeal arterial circulatory path.10-21-2010
20090312645Methods and Devices for Accessing Anatomic Structures - Described herein are methods and devices for performing endoscopic retrograde cholangiopancreatography (ERCP). A system comprising an elongate body housing a front-viewing endoscope and a tissue grasping instrument can be used to facilitate the insertion of a catheter into the ampulla of Vater. The distal end of the elongate body can be positioned such that the operator of the system can view the ampulla while manipulating the surrounding tissue to ease cannulation of the opening with the catheter. As a result, the procedure can be performed faster and more reliably than in the past.12-17-2009
20110118609Imaging Surgical Target Tissue by Nonlinear Scanning - Systems and techniques for laser surgery based on imaging a target tissue by nonlinear scanning are presented. In one implementation, a method for guiding an eye surgery can include the steps of: positioning an eye in relation to an imaging system; creating first scan data by determining a depth of an eye target region at a first set of points along a first arc; creating second scan data by determining a depth of the eye target region at a second set of points along a second arc; determining target region parameters based on the first and second scan data; and adjusting one or more surgical position parameters according to the determined target region parameters.05-19-2011
20120108982SYSTEMS AND METHODS FOR IN-VIVO OPTICAL IMAGING AND MEASUREMENT - Disclosed are methods and systems for: (i) sequentially illuminating a specimen with different spatial distributions of light, wherein each illumination causes an object embedded in the specimen to emit radiation in response to the light; (ii) for each different spatial distribution of illumination light, imaging the radiation emitted from the specimen from each of multiple sides of the specimen; and (iii) determining information about the object in the specimen based on the imaged radiation from each of the multiple sides for each of the different spatial distributions of illumination light.05-03-2012
20120108981APPARATUS AND METHOD FOR SPECTROPHOTOMETRIC MEASUREMENTS OF BLOOD PARAMETERS - An apparatus for measuring the blood parameters in an extracorporeal circuit comprises: a seat (05-03-2012
20100087741METHOD FOR IDENTIFYING MALIGNANCIES IN BARRETT'S ESOPHAGUS USING WHITE LIGHT ENDOSCOPY - A method is described for computing a statistically significant difference between dysplasia and Barrett's esophagus (both with and without inflammatory component) using a discriminate function with diffuse reflectance measurements performed at a minimum of four different wavelengths of 485, 513, 598, and 629 nm. The discriminate function found depends both on local blood fraction volume T04-08-2010
20110201942DEVICE AND METHOD FOR OPTICALLY EXAMINING THE INTERIOR OF A BODY PART - A device for optically examining the interior of a body part by transillumination is provided. The device comprises: an illumination unit (08-18-2011
20120296217METHOD AND APPARATUS FOR DELIVERING AN ENDOSCOPE VIA MICROSURGICAL INSTRUMENTS WHILE PERFORMING MICROSCOPIC SURGERY - The present invention relates to a surgical apparatus that includes a surgical instrument including an elongated shaft extending along a longitudinal axis from a proximal end to a distal end, a working element coupled to the distal end of the elongated shaft for manipulating tissue; an endoscope having a tubular body including an image fiber, an endoscopic lens coupled to a distal end of the tubular body and operably coupled to the image fiber, the endoscopic lens defining a viewing field about a central axis; and the endoscope mounted to the elongated shaft of the surgical instrument, the endoscopic lens protruding from an outer longitudinal surface of the elongated shaft, the central axis of the viewing field being oblique to the longitudinal axis of the elongated shaft and intersecting the outer longitudinal surface, the working element located within the viewing field and separated from the central axis by a distance.11-22-2012
20080312539Methods of Using Optical Agents - In certain aspects, the invention relates to processes for using renally excretable optical agents to detect one or more tissues of the renal system of a surgical patient. In certain aspects, the invention relates to a kit including a biocompatible composition containing one or more optical agents and instructions for using the optical agent(s) in a process of the present invention.12-18-2008
20090088649PROBE DEVICE - A probe device includes a sheet-like probe holder, a plurality of light-emitting probes and a plurality of detection probes mounted on the probe holder at a predetermined interval, a sheet holding unit holding the probe holder at a predetermined position on the biological surface, and a fixing band mounting the sheet holding unit on the living body. Each of the plurality of light-emitting probes and the detection probes includes a probe body including a light emitting unit or a detection unit, and a probe mounting part detachably mounting the probe body to the probe holder at a predetermined position.04-02-2009
20110270093OPTICAL EXAMINATION DEVICE ADAPTED TO BE AT LEAST PARTIALLY INSERTED INTO A TURBID MEDIUM - An optical examination device (11-03-2011
20090275841MULTI-WAVELENGTH DIAGNOSTIC IMAGER - The present invention is a multi-wavelength diagnostic imager. In one embodiment, the present invention includes an apparatus and method for noninvasive evaluation of a target versus a non-target, comprising: one or more light sources having at least one emission spectra directed at the target wherein the position, orientation and intensity of light sources is varied to control near-surface reflectance and are directed at less than the entire target; and one or more detectors positioned to capture light reflected from the target into two or more spatial images of the target at two or more times, wherein the spatial images are used to distinguish between the target and the non-target.11-05-2009
20090099457Health Indicator - A health indicator device comprising a body scanner to obtain a three-dimensional model of a person, a body volume calculator for calculating the volume of at least a first part of the person's body and a second part of a person's body from the three-dimensional model and a health calculating device for calculating an indication of the person's health based on the output from at least the body volume calculator.04-16-2009
20110270092COMBINED APPARATUS FOR DETECTION OF MULTISPECTRAL OPTICAL IMAGE EMITTED FROM LIVING BODY AND FOR LIGHT THERAPY - The present invention provides a fluorescence detection and photodynamic therapy apparatus including: a combined light source unit 11-03-2011
20100298716METHODS AND COMPOSITIONS TO REDUCE SCATTERING OF LIGHT DURING THERAPEUTIC AND DIAGNOSTIC IMAGING PROCEDURES - Disclosed are improved methods and compositions for use in light-based in vivo imaging and treatment. The techniques described involve the use of low-scattering, oxygen-carrying blood substitutes in imaging and treatment methods, including OCT imaging. The invention has particular advantages in imaging within the cardiovascular system and highly vascularized or oxygen-dependent tissues.11-25-2010
20080255462LIGHT STICK - Described herein is a device used to perform medical examinations. The device includes at least one sidewall and at least one end, wherein the sidewall at least partially defines both a chemical housing and a handle portion. The chemical housing preferably includes a light source disposed therein. A reflective layer may be applied to at least a portion of the sidewall defining the chemical housing.10-16-2008
20090118623Instrument and Method for High-Speed Perfusion Imaging - A high-speed laser perfusion imaging instrument including a laser source, a detector, a signal-processing unit, data memory, and a screen to display results. A section of a sample surface is illuminated with laser light; reemitted light from the irradiated surface is collected by focusing optics on a 2D array of integrating photodetectors having elements that can be accessed individually or in a pre-defined selection of pixels at high speed. This 2D array measures intensity variations at each individual pixel. Average amplitude and mean frequency of the measured signal contain information about concentration and speed of moving blood cells. For real-time imaging, exposure time is used as a parameter to measure relative perfusion changes. These data are stored and processed with the signal-processing unit to deliver 2D flow maps of the illuminated sample section, and allow a simple overlay between a conventional image and processed flow maps.05-07-2009
20080269617Absorption and Scattering Map Reconstruction For Optical Fluorescence Tomography - Optical fluorescence tomography is a highly sensitive method to image contrast agents in the body. However, current reconstruction methods suffer from a high complexity or even instability. According to an exemplary embodiment of the present invention, a method for absorption/scattering map reconstruction for optical fluorescence tomography may be provided, which uses a spectral model. This may provide for a subsequent fluorescence reconstruction with improved image quality.10-30-2008
20080287809Biological information measuring apparatus and biological information measuring method - A biological information measuring apparatus measures information of a living body by irradiating the living body with light. The apparatus includes: a first light source irradiating the living body with light; a second light source irradiating the living body with light; and a light receiving section constituted by a plurality of light receiving elements that receives reflected light reflected by the living body or transmitting light transmitting through the living body, during light irradiation of the living body. In the biological information measuring apparatus, the first light source and the second light source are disposed so that a first distance between the light receiving section and the first light source is different from a second distance between the light receiving section and the second light source.11-20-2008
20080287808APPARATUS, PROBE AND METHOD FOR PROVIDING DEPTH ASSESSMENT IN AN ANATOMICAL STRUCTURE - Apparatus and method can be provided for obtaining information regarding at least one portion of an anatomical structure. For example, using at least one first arrangement, it is possible to forward at least one first electromagnetic radiation to the at least one portion. In addition, using at least one second arrangement, it is possible to detect at least one second electromagnetic radiation from the sample, the second electromagnetic radiation being related to the first electromagnetic radiation. The second arrangement can be used to obtain data associated with the second electromagnetic radiation at a plurality of integration times. Further, with at least one third arrangement, it is possible to determine at least one motion characteristic as a function of depth within the portion using the second electromagnetic radiation. The motion characteristic can be determined by obtaining data associated with the second electromagnetic radiation. The data can be speckle data detected by the second arrangement. In addition, using the third arrangement, it is possible to determine optical properties of the portion based on the data. Furthermore, with a fourth arrangement, it is possible to receive the first electromagnetic radiation and generate a plurality of third electromagnetic radiations to irradiate multiple points on the portion. The second arrangement can be used to detect the second electromagnetic radiation from the sample based on the third electromagnetic radiations, and the third arrangement can also be used to determine a plurality of motion characteristics as a function of depth for a plurality of location of the at least one portion as a function of the second electromagnetic radiation.11-20-2008
20100004544OPTICAL TOMOGRAPHIC IMAGING PROBE, AND OPTICAL TOMOGRAPHIC IMAGING APPARATUS USING THE SAME - To enable OCT imaging inside a blood vessel without having to block blood flow, through the use of an optical tomographic imaging probe including: a tubular probe outer casing; an optical fiber disposed inside the probe outer casing in an axial direction of the probe outer casing; a plurality of transparent inflatable/deflatable split balloons provided circumferentially across an outer circumferential surface of a transparent portion of the probe outer casing, through which a light beam is to be emitted from the optical fiber towards an measurement object, so as to equally divide the circumferential direction; and a balloon inflating/deflating device that respectively and individually inflates/deflates each split balloon, images are captured by removing only blood from imaging areas without having to block blood flow, and a tomographic image of the entire circumference of the inner wall of the blood vessel is obtained by compositing the images.01-07-2010
20130218024Interventional In-Situ Image-Guidance by Fusing Ultrasound and Video - An augmentation device for an imaging system has a bracket structured to be attachable to an imaging component, and a projector attached to the bracket. The projector is arranged and configured to project an image onto a surface in conjunction with imaging by the imaging system. A system for image-guided surgery has an imaging system, and a projector configured to project an image or pattern onto a region of interest during imaging by the imaging system. A capsule imaging device has an imaging system, and a local sensor system. The local sensor system provides information to reconstruct positions of the capsule endoscope free from external monitoring equipment.08-22-2013
20090264772FASH FLUORESCENCE IMAGING DEVICE FOR DIFFUSE OPTICAL TOMOGRAPHY - A device for imaging an interior of a turbid medium arranged to couple excitation light from a light source (10-22-2009
20110208064Curcumin Derivatives for Amyloid-Beta Plaque Imaging - The present invention provides curcumin-derived near infrared (NIR) imaging probes. Upon interacting with amyloid β aggregates, these probes undergo a range of changes, qualifying them as “smart” probes. The inventors have demonstrated that probes of the invention have the capacity to monitor the progression of Alzheimer's disease in an in vivo animal model. In addition, the present invention encompasses probes useful as PET imaging agents, MRI imaging agents and multimodal imaging agents, as well as related methods of detecting and imaging amyloid β aggregates and plaques.08-25-2011
20090062660Examination and imaging of brain cognitive functions - A system and method for examining or imaging brain functions of a subject includes a light source and a light detector located on the exterior surface of the subject's head. The light source introduces transcranially optical radiation into the brain of a subject, and the light detector detects radiation that has migrated in a brain region from the light source to the detector. The system also provides brain stimulation and evaluates the detected radiation to determine a brain cognitive function of the subject. One embodiment of the system can detect a brain disorder. Another embodiment of the system can detect “deceit.” In addition to the optical module, the system may include other optional modules such as an EEG module, an MEG module, a thermography module, a respiratory module, a skin conductivity module, and a blood pressure module.03-05-2009
20100210951Optical System for Imaging of Tissue Lesions - The present disclosure, according to one embodiment, relates to an optical device for direct visualization, imaging, and spectroscopic measurements of tissue abnormalities at various anatomical sites. Such sites include, but are not limited to, the oral cavity, the cervix, and the skin. In one embodiment, the device comprises: a frame; at least one light-emitting diode light source mounted on the frame for illuminating a tissue, wherein the at least one light-emitting diode light source is chosen from a fluorescent light source, a polarized white light source, and an unpolarized white light source; at least one loupe mounted on the frame for visually observing the tissue; at least one filter disposed between the tissue and the loupe for filtering light reflected from the tissue; and an energy source operably connected to the at least one light-emitting diode light source.08-19-2010
20090177094SYSTEMS AND METHODS FOR TISSUE EXAMINATION, DIAGNOSTIC, TREATMENT, AND/OR MONITORING - Procedures, techniques, and systems for in vivo monitoring, diagnosis, and treatment of tissue during the same or concomitant medical procedure. In disclosed embodiments, during a same or concomitant procedure or examination, tissue can be scanned on a localized level using a real-time optical biopsy system. The real-time optical biopsy system may involve angle-resolved and/or Fourier domain low coherence interferometry (LCI). Because the scanning can be performed in real-time, diagnosis can also be performed in real-time and during the same or concomitant medical procedure. As a result, therapy, if needed, can also be administered to the tissue during the same or concomitant medical procedure. Monitoring of the tissue after therapy can be performed during the same or subsequent procedure. Thus, the procedures and techniques disclosed herein allow detection of tissue anomalies during a first procedure on the patient without waiting for untimely biopsy results, thus providing earlier anomaly detection and treatment and potentially better and timely results and at a lower cost.07-09-2009
20110144503Optical methods for monitoring of birefringent tissues - The present invention comprises methods and systems/devices for non-invasively measuring birefringent tissues (e.g. collagen) and changes during treatment of tissue, e.g., denaturation by the application of RF energy, through linear dichroism, circular dichroism, or birefringence. The invention optionally uses polarization sensitive optical measurements to discriminate between denaturation of unidirectionally oriented strands of collagen, such as a ligament or tendon, and denaturation of planar collagen surfaces, such as the dermal layer of the skin or collagen in joint capsules.06-16-2011
20110144505OPTICAL DEVICE AND METHOD FOR SHAPE AND GRADIENT DETECTION AND/OR MEASUREMENT AND ASSOCIATED DEVICE - Provided are: an optical device for shape and gradient detection and/or measurement which has a simple structure, is robust to external disturbance, and enables accurate measurement of the gradient angle of an object surface, including a human body; a method for optical shape and gradient detection and/or measurement; and a circularly polarized light illumination device. The optical device for shape and gradient detection and/or measurement uses the optical reflection characteristics of the surface of an object to detect and/or measure the surface shape or gradient of an observed object, and is provided with an illumination device and a polarized light image detection device. The illumination device makes the incident light, which surrounds the periphery of the object and is essentially a known perfect polarized light, fall uniformly. The polarized light image detection device detects a polarized light ellipse of the perfectly polarized light component of a light beam group, which is specularly reflected by the object surface and radiated at a particular azimuth angle. The optical device measures the gradient angle with respect to the radiated light beam of the reflection surface in a step 1 in which the orientation of the incident plane is detected from the observed azimuth angle value of the polarized light ellipse for the reflecting surface of the object which forms an incident point for each reflected and radiated light beam, and a step 2 in which the incident angle is detected from the ellipticity logic value of the polarized light ellipse. The method for optical shape and gradient detection and/or measurement is carried out using the same operation.06-16-2011
20110144504METHOD AND APPARATUS FOR OPTICAL IMAGING VIA SPECTRAL ENCODING - Method, apparatus and arrangement according an exemplary embodiment of the present invention can be provided for generating an image of at least one portion of an anatomical structure. For example, the portion can have an area greater than about 1 mm2, and the image can have a resolution a transverse resolution that is below about 10 μm. For example, light can be scanned over such portion so as to generate first information which is related to the portion, where the light may be provided through a diffraction arrangement to generate a spectrally dispersed line. Method, apparatus and arrangement according to a further exemplary embodiment of the present invention can be provided for positioning a radiation or optical beam within an anatomical structure based on signals generated by scanning a portion of the structure using the same or a different beam.06-16-2011
20090143685Method and Apparatus for Detecting Diseases Associated with the Eye - Disease may be detected, monitored, etc. by detecting metabolic dysfunction in a patient's eyes. In one embodiment of an apparatus, an excitation light is generated by an excitation light source to induce autofluorescence in an ocular tissue (e.g., retinal tissue), wherein the excitation light excites flavoprotein autofluorescence (FA) and minimizes the excitation of non-flavoprotein autofluorescence. At least a single image representing the induced ocular tissue autofluorescence is captured. The at least single image is intensified to increase the signal strength of the ocular tissue autofluorescence. The at least single image is analyzed to generate an indicator of whether a patient has one or more of eye damage, a disease that causes eye damage, or to generate an indicator of the progression of a disease, an indicator of the effectiveness of a treatment, a personalized treatment for a subject, etc.06-04-2009
20080319322Non-invasive in-vivo imaging of mechanoreceptors in skin using confocal microscopy - Meissner's Corpuscles (MCs) are touch-pressure sensation receptors in glabrous skin. They are imaged by reflectance confocal microscopy to provide a non-invasive, in vivo quantification of their density or size to allow screening for, diagnosis or monitoring of sensory neuropathy and other peripheral nervous system disorders related to diabetes, HIV, or other conditions.12-25-2008
20090326384Device With Integrated Multi-Fiber Optical Probe and Methods of Use - Biopsy instruments are integrated with a multi-fiber optical probe adapted to perform diagnostic measurements. In addition to being able to analyze, treat or remove tissue, such integrated devices characterize tissue by measuring the amount of scattering and absorption of light transmitted into the tissue. Each fiberoptic probe has an illuminating fiber that provides a broadband light source for transmission into tissue, and a collecting fiber that collects the light scattered by the tissue and transmits the collected light to a spectrometer. One embodiment is an endoscope-mediated tool with a jaw-type biopsy forceps and a multi-fiber optical probe which is conveyed through a hollow central channel. Another embodiment is an endoscope-mediated tool with a jaw-type biopsy forceps and a plurality of multi-fiber optical probes. Yet another embodiment is an endoscopic polypectomy-type snare catheter with a multi-fiber optical probe located at the tip.12-31-2009
20090326383SYSTEMS AND METHODS FOR HYPERSPECTRAL IMAGING - An apparatus for analyzing a subject including a hyperspectral image module is provided. It is used to identify a suspect region of a subject by using a hyperspectral sensor (for obtaining a hyperspectral image of the subject), a control computer including a processor unit (PU) and a computer readable memory (CRM) (for controlling and is in electronic communication with the sensor), a control software module including instructions stored in the CRM and executed by the PU (for controlling said at least one operating parameter of the sensor), a spectral calibrator module including instructions stored in the CRM and executed by the PU (for applying a wavelength dependent spectral calibration standard constructed for the sensor to a hyperspectral image), and a light source for illuminating the subject. An optional contact probe module is used to collect a signal of the suspect region for medical diagnosis.12-31-2009
20090326382OPTICAL IMAGING SYSTEM AND METHOD - A device for determining a concentration-related quantity of a fluorescent contrast agent applied to an object (12-31-2009
20090247882LIVING BODY HOLDING DEVICE - A concave accommodating section is formed inside a base body. The accommodating section has a shape substantially the same as the left half of a mouse. The mouse is put in the accommodating section in a lying posture with its left side down such that a surface wall of the accommodating section directly contacts with a body surface of the left half of the mouse. Thus, the mouse and its tumor are held in predetermined positions. The right half of the mouse including a body part of interest is exposed from the accommodating section.10-01-2009
20090247881IMAGE CAPTURING APPARATUS, IMAGE CAPTURING METHOD, AND COMPUTER READABLE MEDIUM - Provided is an image capturing apparatus comprising a light emitting section that emits light to a subject; a light receiving section that receives light in a first wavelength region and light in a second wavelength region from the subject, the second wavelength region being different from the first wavelength region; a reflectance calculating section that calculates a first reflectance of light in the first wavelength region from the subject and a second reflectance of light in the second wavelength region from the subject, based on the light emitted by the light emitting section and the light received by the light receiving section; and a depth identifying section that calculates a depth, from a surface of the subject, of an object inside the subject that is included in an image resulting from the light received by the light receiving section, based on the first reflectance and the second reflectance.10-01-2009
20130218025CLIP SENSOR DEVICE FOR MEASUREMENT OF VITAL SIGNS - A clip sensor device for optical measuring vital signs of a subject is provided. The clip sensor device includes a internal supporting frame formed from an elongated plate configured to be folded into a desired orientation. A measuring probe is mounted on an upper surface of the frame. The measuring probe comprises a transmitter and receiver and configured for generating a time response of the blood perfused body tissue to the applied optical signal that is indicative of the vital signs of the subject. The clip sensor device also includes a pressing member mounted on the upper surface of the internal supporting frame. The pressing member includes one or more spring elements configured to provide a predetermined pressure on the blood perfused body tissue due to the deformation of the spring elements when said portion of blood perfused body tissue is applied against the pressing member.08-22-2013
20130218023METHODS FOR DIAGNOSIS OF COLORECTAL CANCER - Methods and systems for use of phenotypic markers, principally oral mucosal vascular density alone or in combination with detection of other markers, to identify individuals afflicted with or having an increased risk of hereditary colorectal cancer, especially familial adenomatous polyposis, are disclosed.08-22-2013
20090192390Common bile duct surgical imaging system - A method and apparatus for imaging features of a CBD in a patient introduces a fluorescent contrast agent into the CBD. A light source transmits both a visible light and a fluorescent light into a patient's abdominal cavity via the laparoscope. Cameras attached to or integrated into the laparoscope detect visible light images and fluorescent emission light images. The visible light image and fluorescent image signals are processed to combine the fluorescent emission light image signals and visible image signals into a single display signal. The system adjusts the display characteristics, such as color, of the fluorescent emission light image so it contrasts well with the visual light image so the surgeon can easily distinguish between the two images. The display signal is sent to a video monitor where the surgeon views the visible light image and the fluorescent image as a single overlaid image.07-30-2009
20090054786IMAGING SYSTEMS AND METHODS, PARTICULARLY FOR USE WITH MEDICAL INSTRUMENT USED IN OPEN SURGERY - An electronic assembly (and related methods of manufacture and use), comprising: a non-conducting substrate, which has front and back sides and comprises through-wires molded into the substrate so as to pass through the substrate from the front side to the back side; and an integrated circuit device, which is fixed to the front side of the substrate and electrically connected to the through wires at the front side of the substrate. In certain embodiments, the integrated circuit device may be an image sensor. In one possible embodiment, the assembly is used as a compact camera that is associated with a surgical instrument used in open surgery.02-26-2009
20090209866APPARATUS AND METHOD FOR MEASURING ANATOMICAL OBJECTS USING COORDINATED FLUOROSCOPY - Two fluoroscopic images taken from two different angles of the same anatomical feature are registered to a common three-dimensional coordinate system. A dimension of the anatomical feature is determined by specifying with reference to the two registered fluoroscopic images two constrained points within the three-dimensional coordinate system that correspond to the boundaries of the anatomical feature, and calculating a straight-line distance between the two. Additionally, a three-dimensional virtual model of an implant is projected into each of two, registered fluoroscopic image, and a surgeon manipulates the projections to adjust the size and shape of the virtual model, and thereby determine parameters for the implant.08-20-2009
20090062661SENSOR FOR MEASURING LIVING BODY INFORMATION AND EARPHONE HAVING THE SAME - A sensor for measuring living body information includes a light guide member for guiding a first light; a light extracting member, disposed adjacent to the light guide member, for outputting the first light guided by the light guide member to an exterior of the light guide member through contact with the light guide member; and a light coupling member, disposed adjacent to the light guide member, for coupling a second light to the light guide member through contact with the light guide member.03-05-2009
20090054789Head-coupled holder for living body optical measurement - A head-coupled holder for living body optical measurement that securely brings a light irradiation module and a light detection module in close contact with a scalp, and gives the person to be examined no excessive pressure feeling. Each of the light irradiation module and the light detection module includes a contactor having a contact portion that comes in contact with a scalp of the person to be examined at a leading end thereof, and exposes a leading end of a light guide to the contact portion to form the light guide, and a package having a lower portion to which the contactor is attached. The contactor is fixed to the lower portion of the package through an elastic body, and the package is fixed to an inner upper wall of the insertion hole with a series structure of the elastic body and the viscoelastic body.02-26-2009
20120078117BLOOD VESSEL INNER WALL ANALYZING DEVICE AND BLOOD VESSEL INNER WALL ANALYZING METHOD - The present invention relates to a blood vessel inner wall analyzing apparatus provided with a structure for more accurately analyzing components of substances adhered to the inner walls of blood vessels. A blood vessel inner wall analyzing apparatus (03-29-2012
20120078116BIOLOGICAL INFORMATION DETECTOR AND BIOLOGICAL INFORMATION MEASURING DEVICE - A biological information detector includes a light-emitting part for emitting light in an emission wavelength band that includes a wavelength of interest, a light-receiving part for receiving light R03-29-2012
20120078115METHODS TO MEASURE, MAP AND CORRELATE OCULAR MICRO-MOVEMENT AND OCULAR MICRO-TREMOR SIGNALS WITH COGNITIVE PROCESSING CAPABILITIES - An apparatus and method of collecting elements of and assembling various portions of ocular micro motions such as ocular micro-tremor (OMT) movements of the eye, and correlating them directly with OMT waveforms acquired from both known and unknown states of cognition and cognitive function. Comparing newly acquired waveforms from patients with undiagnosed cognitive dysfunctions, permits an individual or caregiver the ability to identify those unknown issues or cognitive states based on matching or relating statistically elements of their waveform with categories of other known cognitive processing normals and abnormals, functional and dysfunctional individuals. It also allows for measuring the effects of therapeutic agents (psychological or pharmacological) by relating them to measurable changes in cognitive function as a result of correlated changes in waveforms.03-29-2012
20090204010Vein imaging apparatus - A vein imaging device that is capable of achieving space saving. The vein imaging device includes an imaging section and a guide member. The imaging section images a vein pattern of a palm. The guide member is erected on a periphery of an imaging surface of the imaging section. The guide member guides the position of the palm with respect to the imaging surface of the imaging section, by having a finger brought into contact therewith at a predetermined height position from the imaging surface of the imaging section.08-13-2009
20120197135DEVICE FOR INTERMITTENTLY PERFORMING CARE SESSIONS TO FORM A LARGE SKIN AREA CARE - A device of guiding a multiple area dermatologic care process. The device comprises a carrier which supports a drive of a dermatologic care tool over a skin area while the dermatologic care tool intermittently performs a plurality of dermatologic care sessions each in one of a plurality of skin subareas of the skin area and a brake unit which regulates a movement of the carrier from a first skin subarea to a second skin subarea during the drive of the dermatologic care tool.08-02-2012
20090209867METHOD FOR RAPID SCREENING OF MAD COW DISEASE AND OTHER TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES - Methods for diagnosing altered neuropathology in an animal are disclosed, wherein said methods comprise imaging brain, spinal cord, or other neural tissue of the animal, analyzing the appearance of the tissue, and determining whether the appearance of the tissue is altered relative to corresponding unaltered tissue. Also disclosed are methods for diagnosing spongiform encephalopathies in an animal, wherein said methods comprise imaging brain, spinal cord, or other neural tissues of the animal, analyzing the appearance of vacuoles in the tissue, and determining whether the appearance of the vacuoles in the tissue is altered relative to corresponding spongiform encephalopathy-free tissue. Also disclosed are automated methods for diagnosing altered neuropathy and spongiform encephalopathies.08-20-2009
20090259130OPTICAL TOMOGRAPHY MEASUREMENT USING AN ADAPTED BRIM FOR THE RECEIVING VOLUME - The invention relates to a device for imaging an interior of a turbid medium comprising: a) a receiving volume for receiving at least a part of the turbid medium, with the receiving volume being bound by a boundary having an opening bound by a brim, b) a light source for irradiating the turbid medium, and c) a photodetector unit for detecting light emanating from the volume as a result of irradiating the turbid medium. The device is adapted such that the brim is arranged for optically coupling the light source to the turbid medium and the turbid medium to the photodetector unit. One embodiment of the invention relates to a device for imaging an interior of a female breast comprising a cup-like receptacle (10-15-2009
20090253990OPTICAL DIAGNOSIS OF HEMOPHILIC JOINT EFFUSION - Non-invasive systems and methods to distinguish between blood and synovial fluid in patients are described. In one embodiment, the system comprises a patient interface system that can be placed over a swollen joint. A region of the swollen joint is illuminated with radiation. The scattered or transmitted radiation from the region of effusion is collected by a collection system and detected by a radiation detector. The information from the detector is analyzed by an analytic processing system to diagnose the cause of the joint effusion.10-08-2009
20090137909METHOD FOR IMAGING AND TREATING ORGANS AND TISSUES - The present invention provides methods and compositions for detecting and treating malignant tissue, organs or cells in a mammal. The method comprises parenterally injecting a mammalian subject, at a locus or by a route providing access to the tissue or organ, with a composition comprising an antibody/fragment that is tagged with a fluorophore and a therapeutic isotope molecule, which specifically binds to the targeted organ, tissue or cell.05-28-2009
20100160789System and Method for Determining Volume-Related Parameters of Ocular and Other Biological Tissues - A system and method for determining volume-related parameters of a biological tissue, such as ocular tissue, include a light source for projecting light towards the biological tissue, a receiver for receiving light reflected from the biological tissue at two spectral wavelengths, and an image acquisition system in communication with the receiver for forming an image from the reflected light at each wavelength. A processor applies a mathematical model to the image which compares the absorption of light by the biological tissue at a selected image point at each of the two spectral wavelengths to determine the volume-related parameters, such as the relative thickness and material properties, of the biological tissue at that location.06-24-2010
20100262019METHOD AND APPARATUS FOR DETERMINING TARGET DEPTH, BRIGHTNESS AND SIZE WITHIN A BODY REGION - A method of investigating the location and size of a light-emitting source in a subject is disclosed. In practicing the method, one first obtains a light intensity profile by measuring, from a first perspective with a photodetector device, photons which (i) originate from the light-emitting source, (ii) travel through turbid biological tissue of the subject, and (iii) are emitted from a first surface region of interest of the subject. The light-intensity profile is matched against with a parameter-based biophotonic function, to estimate function parameters such as depth and size. The parameters so determined are refined using data other than the first measured light intensity profile, to obtain an approximate depth and size of the source in the subject. Also disclosed is an apparatus for carrying out the method.10-14-2010
20120197134Lesion Extracting Device and Lesion Extracting Method - A lesion extracting device includes a light source for emitting an excitation light toward a subject body, a control unit for changing an amount of the excitation light, a light irradiating and receiving portion for irradiating the excitation light to the subject body and receiving fluorescence generated from the subject body, a distance holding member for holding a distance between the subject body and the light irradiating and receiving portion at a predetermined value, a measuring unit for measuring the intensity of the fluorescence received by the light irradiating and receiving portion, and an extracting unit for extracting a lesion part of the subject body based on relationships between measured values of changes in the fluorescence intensity with respect to changes in the amount of the excitation light and information regarding the changes in the amount of the excitation light, the information being obtained from the control unit.08-02-2012
20100262017MULTI-CHANNEL MEDICAL IMAGING SYSTEM - A medical imaging system provides simultaneous rendering of visible light and fluorescent images. The system may employ dyes in a small-molecule form that remain in a subject's blood stream for several minutes, allowing real-time imaging of the subject's circulatory system superimposed upon a conventional, visible light image of the subject. The system may provide an excitation light source to excite the fluorescent substance and a visible light source for general illumination within the same optical guide used to capture images. The system may be configured for use in open surgical procedures by providing an operating area that is closed to ambient light. The systems described herein provide two or more diagnostic imaging channels for capture of multiple, concurrent diagnostic images and may be used where a visible light image may be usefully supplemented by two or more images that are independently marked for functional interest.10-14-2010
20100191125APPARATUS AND METHOD FOR OBTAINING GEOMETRICAL DATA RELATING TO A CAVITY - Disclosed is an apparatus for obtaining geometrical data relating to an internal surface of a cavity. The apparatus comprises a probe having an end portion insertable into the cavity in a direction of insertion, radiation directing means for directing electromagnetic radiation from the end portion to at least one location on the internal surface to cause the radiation to be reflected from said location, detection means for detecting the reflected radiation from the at least one location, and means for determining from the detected radiation a distance between the probe and the internal surface in a direction having at least a transverse component relative to the direction of insertion. The radiation directing means is adapted to direct the radiation at an acute angle relative to the direction of insertion.07-29-2010
20110060227TISSUE VISUALIZATION AND MANIPULATION SYSTEM - Tissue visualization and manipulation systems are described herein. Such a system may include a deployment catheter and an attached imaging hood deployable into an expanded configuration. In use, the imaging hood is placed against or adjacent to a region of tissue to be imaged in a body lumen that is normally filled with an opaque bodily fluid such as blood. A translucent or transparent fluid, such as saline, can be pumped into the imaging hood until the fluid displaces any blood, thereby leaving a clear region of tissue to be imaged via an imaging element in the deployment catheter. Additionally, any number of therapeutic tools can also be passed through the deployment catheter and into the imaging hood for treating the tissue region of interest.03-10-2011
20120197133Advanced Ultrasound Modulated Optical Spectroscopy And Its Application To Patient Monitoring - The present disclosure describes systems and methods that use spatial modulation to focus light into a localized region of interest such as an individual blood vessel. In certain embodiments, acoustic modulation techniques, such as ultrasound pulse modulation, are used in conjunction with spatial modulation to achieve more precise measurements through otherwise scattering medium. The focused beam of light is capable of penetrating several centimeters of tissue to deliver measurements and images associated with individual blood vessels and other discrete vascular components.08-02-2012
20100217130DEVICE FOR THE PRODUCTION OF PHOTOGRAPHIC IMAGES IN THE MOUTH REGION - The invention relates to a device for the standardized and reproducible measurement and/or photography of the head, or of head regions, particularly of the intraoral region, characterized in that said device comprises—a cranial support (08-26-2010
20130123641METHOD AND APPARATUS FOR ANALYZING SUBSURFACES OF A TARGET MATERIAL - A system that incorporates teachings of the present disclosure may include, for example, a method for aligning first and second light signals on an optical path directed to a target, where the first light signal provides a visualization of the target, and a portion of the second light signal reflects from at least one subsurface of the target. The method also includes aligning a first focal point of the first light signal and a second focal point of the second light signal, where the first focal point is at least in a first proximate location of the second focal point, and adjusting a first position of the first and second focal points to be in at least a second proximate location of the target without adjusting the at least first proximate location of the first focal point relative to the second focal point. Other embodiments are disclosed.05-16-2013
20130123643MEASURING ARRANGEMENT FOR RECORDING A SPECTRUM, IN PARTICULAR FROM VITAL TISSUE - The invention relates to a measuring arrangement having a mobile spectrometer device which comprises a measuring head structure, wherein the measuring head structure is designed in such a way that, to carry out the spectrometric measurement, it can be placed on a portion of tissue, and a socket element which forms an inner receiving space into which the measuring head structure can be inserted, wherein a calibrating medium, produced from an opaque material, is arranged in a bottom region bounding the inner receiving space, and the socket element and the measuring head structure are designed such that, after the measuring head structure has been introduced into the socket element, the calibrating medium is sealed off in a light-tight manner from the surroundings.05-16-2013
20130123644OPTICAL MEASUREMENT APPARATUS, ENDOSCOPE SYSTEM, AND COMPUTER READABLE STORAGE MEDIUM - An optical measurement apparatus of the present invention includes a light source unit; an operation unit that performs an operation process on the basis of a result of the measurement performed by a measurement unit to obtain a characteristic value of a living tissue; a validity evaluator that evaluates, on the basis of an operation result of the operation process performed by the operation unit, whether the result of the measurement is valid; an output unit that outputs a result of the evaluation performed by the validity evaluator; an input unit that inputs an instruction to adopt the result of the measurement performed by the measurement unit; and a determination unit that determines, on the basis of the result of the evaluation performed by the validity evaluator and the instruction information from the input unit, whether to adopt the result of the measurement performed by the measurement unit.05-16-2013
20130123646METHOD AND ELECTRONIC DEVICE FOR REMOTE DIAGNOSIS - The present invention relates to a remote treatment method and an electronic device. More specifically, the present invention provides a remote treatment method and an electronic device that guide a manipulation of a checkup tool.05-16-2013
20100241006APPARATUS FOR DETECTING BRAIN CONDITIONS - Disclosed embodiments relate to an apparatus for detecting brain conditions. The apparatus for detecting brain conditions may include: a layer which is located adjacent to the brain of a living body; a light source which is formed on the layer and irradiates light to the brain; and an optical sensor which is formed on the layer adjacent to the light source and detects the light scattered from the brain. Since detection is possible at a location relatively adjacent to the brain, the apparatus for detecting brain conditions may improve accuracy and reliability of detection. The apparatus for detecting brain conditions may be used to detect brain conditions such as cerebral oxygenation, cerebral blood volume, cerebral blood flow, etc. or to monitor brain activities, or to diagnose and/or localize the disease foci in case of neurovascular disease such as stroke including hemorrhage or bleeding, into or around the brain or brain tumors or epilepsy, etc. Since the apparatus for detecting brain conditions has a relatively flexible structure, damage to the brain tissue may be minimized.09-23-2010
20090024041Apparatus for measuring bio-information - Disclosed is an apparatus for measuring bio-information of a user. The apparatus includes an input device for receiving basic bio-information of the user, a first light source radiating a first light having a first wavelength on the surface of the skin, a second light source radiating a second light having a second wavelength on the surface of the skin, a third light source arranged so as to be placed in a more distant position from a photo detector than the first and the second light sources, said third light source radiating a third light having a third wavelength on the surface of the skin, the photo detector for detecting a first, second and third detection lights transmitted through the surface of the skin and converting said first, second and third detection light into electrical signals, said first, second and third detection light corresponding to said first, second and third wavelengths and a control unit for enabling the first, second and third light sources to be driven in a known order and for producing bio-information of the user on the basis of the inputted basic bio-information and intensities of the first, second and third detection lights.01-22-2009
20090076396Optical wavelength range for high contrast imaging of cancer - An apparatus for imaging cancer in which cancer tissue is contrasted against adjacent healthy tissue. The apparatus includes illumination and, possibly polarization means configured to provide illumination light on a region of tissue. Detection means are optically coupled to the illumination means, the detection means being adapted to detect reflected light from the tissue (and its polarization state, if applicable) when the tissue is illuminated by the illumination means. Filtering means are optically coupled to the detection means. The filtering means are configured to filter the illumination light and/or reflected light to pass only light within a range, or any subrange between about 1050 to about 1400 nm. Methods for imaging cancer contrast cancer tissue against adjacent healthy tissue.03-19-2009
20090043210DATA DETECTION DEVICE AND DATA DETECTION METHOD - A data detection device (02-12-2009
20110112407Multispectral detection and presentation of an object's characteristics - An apparatus for capturing a multispectral image of an object is described. The apparatus includes one or more means for transmitting a beam of laser light at a first wavelength and a beam of laser light at one or more additional wavelengths different from the first wavelength. There is a means for causing the beams of laser light to travel in a coaxial path and a moving mirror. The beams of light bounce off the mirror thereby producing a two dimensional projection pattern. This pattern travels from the mirror along a first path to an object and wherein some of the laser light penetrates the object and travels to an internal structure of the object. The reflection of the laser light returns to a photo detector along a path different from said first path.05-12-2011
20110028850Process for quantitative display of blood flow - A method for the quantitative representation of the blood flow in a tissue or vascular region is based on the signal of a contrast agent injected into the blood. In the method, several individual images of the signal emitted by the tissue or vascular region are recorded at successive points in time and are stored. Based on the respective signal, a quantity characteristic for the blood flow and a quantity characteristic for the position of the blood vessels are determined for image areas of individual images. These quantities are represented superimposed for the respective image areas such that both the blood flow quantity and the position of the fine blood vessels become clearly visible in the representation and can be differentiated from the tissue.02-03-2011
20120143064MUSCLE FUNCTION EVALUATING SYSTEM - A muscular function monitoring and evaluating system includes a processor, a wireless interface, a display, a storage device storing a program and sets of test procedures, a signal collection device wirelessly coupled to the processor and a sensor connected to the signal collection device. The program, when executed by the processor, causes the system to display a patient information screen on the display for an operator to input patient's data of a patient to be tested, and receive the patient's data input through the screen. The processor displays, in accordance with one of the sets of test procedures, a muscle map indicating a place on the patient's body to which the sensor is to be attached. The processor instructs the patient through displayed instruction language, an animation or video image, or audible instructions.06-07-2012
20090012403METHOD FOR DETERMINATION OF BONE FRACTURE RISK USING RAMAN SPECTROSCOPY - A method is disclosed for analyzing keratinized tissue, particularly fingernails, of a subject to diagnose osteoporosis and bone fracture risk. A Raman spectrum of a sample of keratinized tissue is generated. Broad spectral background features of the spectrum are removed, preferably by using Fourier transform analysis. Peak heights of Raman features of interest, particularly the S—S bond of cystine, are measured. These peak height measurements are normalized using reference peak heights of Raman features that are invariant between normal and osteoporotic subjects, such as the CH01-08-2009
20090281432BIOLOGICAL PATTERN IMAGING DEVICE, BIOLOGICAL PATTERN IMAGING METHOD, AND BIOLOGICAL PATTERN IMAGING PROGRAM - To lighten influences of external light when picking up images of biological patterns. The biological pattern imaging device includes a casing having an opening part on one of surfaces. The opening part is in a size that is about to be covered in a closed state when a biological part is placed thereon. The casing contains a light source for irradiating the biological part placed on the opening part, and an imaging part for picking up an image of the irradiated biological part.11-12-2009
20100198079METHOD AND DEVICE FOR EASY ACCESS TO VASCULAR GRAFT CANNULATION SITES - The present invention relates to a polymeric venous implant wherein at least a portion of the graft is made from a UV fluorescing polymer which allows the user to see the graft during access use. This allows the graft to be injected much easier by the ability of the technician to find the graft or a stick site on the graft.08-05-2010
20090187109METHOD AND APPARATUS FOR EXAMINING TISSUE FOR PREDEFINED TARGET CELLS, PARTICULARLY CANCEROUS CELLS, AND A PROBE USEFUL IN SUCH METHOD AND APPARATUS - A method, apparatus and probe for examining tissue for the presence of target cells, particularly cancerous cells, by subjecting the tissue to be examined to a contrast agent containing small particles of a physical element conjugated with a biological carrier selectively bindable to the target cells. Energy pulses are applied to the examined tissue. The changes in impedance and/or optical characteristics of the examined tissue produced by the applied energy pulses are detected and utilized for determining the presence of the target cells in the examined tissue. In a described preferred embodiment, the applied energy pulses include laser pulses, and the physical element conjugated with a biological carrier is a light-sensitive semiconductor having an impedance which substantially decreases in the presence of light. The same probe used for detecting the targeted cells may also be used for destroying the cells so targeted.07-23-2009
20100222684Estimating Physical Parameters Using Three Dimensional Representations - Methods, systems, and apparatus for estimating physical parameters using three dimensional representations. In one aspect, predetermined light patterns are projected onto an object and light patterns resulting from an interaction of the projected light patterns and portions of the object are detected. Three dimensional locations of multiple light elements in the detected light pattern are determined, and physical parameters of the object, for example, weight, are estimated based on the locations.09-02-2010
20100305454METHOD FOR EVALUATING BLUSH IN MYOCARDIAL TISSUE - Vessel perfusion and myocardial blush are determined by analyzing fluorescence signals obtained in a static region-of-interest (ROI) in a collection of fluorescence images of myocardial tissue. The blush value is determined from the total intensity of the intensity values of image elements located within the smallest contiguous range of image intensity values containing a predefined fraction of a total measured image intensity of all image elements within the ROI. Vessel (arterial) peak intensity is determined from image elements located within the ROI that have the smallest contiguous range of highest measured image intensity values and contain a predefined fraction of a total measured image intensity of all image elements within the ROI. Cardiac function can be established by comparing the time differential between the time of peak intensity in a blood vessel and that in a region of neighboring myocardial tissue both pre and post procedure.12-02-2010
20130137992PAIN-RELIEF DEVICE - Existing pain-relief devices have the problem that the use thereof requires specialized knowledge of Eastern acupuncture, e.g. meridians and acupuncture points, making it difficult for ordinary people to use said devices to relieve pain in painful areas. The disclosed pain-relief device is provided with: a small camera that, in step ST05-30-2013
20100312122SYSTEMS FOR INTRAOPERATIVE NERVE IMAGING - Disclosed are systems for intraoperative nerve imaging using compact high collection power imaging devices for fluorescence and white light imaging of myelin basic protein (MBP) nerve imaging agents during open and minimally invasive surgery.12-09-2010
20100331705METHOD FOR DETECTING THE PRESENCE OF INHOMOGENEITIES IN AN INTERIOR OF A TURBID MEDIUM AND DEVICE FOR IMAGING THE INTERIOR OF TURBID MEDIA - A method for detecting the presence of inhomogeneities in an interior of a turbid medium (12-30-2010
20100331707BIOLOGICAL INFORMATION IMAGING APPARATUS, BIOLOGICAL INFORMATION ANALYZING METHOD, AND BIOLOGICAL INFORMATION IMAGING METHOD - A biological information imaging apparatus includes: a light source; an acoustic wave detector that detects an acoustic wave generated from a light absorption material in a living body that has absorbed a part of energy of light irradiated from the light source to the living body, and converts it into a first electric signal; a photodetector that detects optical intensity of a portion of the light irradiated from the light source to the living body and propagating in the living body, and converts it into a second electric signal; and a calculation unit that calculates optical property distribution information on the living body by making use of an analytical result of one of the first electric signal and the second electric signal for analysis of the other electric signal.12-30-2010
20100331706OPTICAL ANALYZER - An optical analyzer performing analysis excellent in spatial resolution and in invasion depth is provided. The analyzer includes a diagnostic light source section including a seed light source which outputs seed light, and a silica optical fiber to which seed light is input and which generates diagnostic light having a HE11 mode field pattern utilizing a nonlinear optical phenomenon, an irradiation optical system converging the diagnostic light and irradiating a measurement subject with the diagnostic light, an acquisition optical system acquiring object light generated at the measurement subject, a spectrum measurement section receiving the object light and measuring a frequency spectrum of the object light, a storage section storing information of a frequency spectrum of a known substance, and an arithmetic section calculating a correspondence between the frequency spectrum of the object light and the frequency spectrum of the known substance, and analyzing the measurement subject based on the calculation result.12-30-2010
20110034810MULTIPLE IMAGES, MULTIPLE EXPOSURE TIMES, OPTICAL IMAGING OF BLOOD CIRCULATION VELOCITIES - A method of measuring blood velocity includes obtaining a first velocity image by illuminating a tissue surface with a light source for a first exposure time, obtaining a second velocity image by illuminating the tissue surface with the light source for a second exposure time, computing a first average intensity of a first pixel block at a first predetermined location of the first velocity image and a second average intensity of a second pixel block at a second predetermined location of the second velocity image, identifying mid-range velocities of the first and second pixel blocks, computing an optimal optical coherence parameter based on the mid-range velocity of the first pixel block and the mid-range velocity of the second pixel block, and iteratively re-computing the first velocity image and the second velocity image using the optimal optical coherence parameter.02-10-2011
20110040192METHOD AND A SYSTEM FOR IMAGING AND ANALYSIS FOR MOLE EVOLUTION TRACKING - A mole monitoring system including: (a) a calibration fixture including an illuminator that is operational to illuminate a skin area that includes a mole; (b) a digital camera operational to acquire at least one image of a body area that is included in the illuminated skin area and which includes the mole and its environment; and (c) a processor operational to analyze the at least one image of the mole and to determine values for parameters of the mole.02-17-2011
20090062659MEDICAL DEVICE INCLUDING SCANNED BEAM UNIT WITH OPERATIONAL CONTROL FEATURES - A method of controlling a medical device is provided. The method includes generating a beam of radiation using a radiation source assembly. The beam of radiation is directed toward a distal end of the medical device using an optical fiber. The beam of radiation is directed onto an area of interest by scanning the reflector in a scanning pattern, the reflector receiving the beam of radiation from the optical fiber. Radiation is collected from the area of interest using a collector to generate a signal for use in producing a viewable image. A loss of scan condition of the reflector is detected automatically by a control system.03-05-2009
20090062658POSITION TRACKING AND CONTROL FOR A SCANNING ASSEMBLY - A scanned beam imaging system including a radiation source configured to provide a beam of radiation, a movable element configured to direct the beam of radiation onto a scanned area, and a collector configured to receive radiation returned from the scanned area. The imaging system further includes a housing that houses the movable element therein and a reference mark coupled to or received in the housing. The reference mark is positioned such that at least part of the radiation from the radiation source is directable at the reference mark.03-05-2009
20110245684OPTICAL IMAGING DIAGNOSTIC APPARATUS AND THE DISPLAY CONTROL METHOD THEREOF - An optical imaging diagnostic apparatus including: a designating unit for designating a predetermined circumferential-direction position at the circumference of the transmitting and receiving unit on the cross-sectional image displayed; an extraction unit for extracting, within the plurality of line data used for the generation of the cross-sectional image, line data corresponding to circumferential-direction position designated in the designating unit from the storage unit; a calculation unit for calculating attenuation rate in a predetermined region in a radial direction of a body lumen with respect to the extracted line data; and a display unit for displaying the calculated attenuation rate.10-06-2011
20110245683OPTICAL IMAGING DIAGNOSTIC APPARATUS AND THE DISPLAY CONTROL METHOD THEREOF - An optical imaging diagnostic apparatus includes a calculation unit for respectively calculating signal-intensity change in the circumferential direction of the circumference of the transmitting and receiving unit and signal-intensity change in the radial direction of a body lumen respectively with respect to a plurality of line data used for generation of a cross-sectional image displayed; a specifying unit for judging, based on the calculated result in the calculation unit, whether or not there exists scatter which scatters the light transmitted from the transmitting and receiving unit in an blood flow area of the body lumen and for specifying the position on the displayed cross-sectional image of the scatter in case of being judged that there exists the scatter; and a display unit for displaying a marker indicating that the scatter exists at the specified position on the displayed cross-sectional image.10-06-2011
20110125028Vein scanner - A portable vein viewer apparatus may be battery powered and hand-held to reveal patient vasculature information to aid in venipuncture processes. The apparatus comprises a first laser diode emitting infrared light, and a second laser diode emitting only visible wavelengths, wherein vasculature absorbs a portion of the infrared light causing reflection of a contrasted infrared image. A pair of silicon PIN photodiodes, responsive to the contrasted infrared image, causes transmission of a corresponding signal. The signal is processed through circuitry to amplify, sum, and filter the outputted signals, and with the use of an image processing algorithm, the contrasted image is projected onto the patient's skin surface using the second laser diode. Revealed information may comprise vein location, depth, diameter, and degree of certainty of vein locations. Projection of vein images may be a positive or a negative image. Venipuncture needles may be coated to provide visibility in projected images.05-26-2011
20110125032Devices and Methods for the Treatment of Endometriosis - A tissue treatment device comprises an insertion section sized and shaped for insertion into the body via a trocar and a diagnostic element coupled to the insertion section, the diagnostic element illuminating tissue with light of a wavelength selected to facilitate identification of target tissue in combination with an ultrasound element coupled to the insertion section for delivering to a portion of tissue illuminated by the diagnostic element ultrasound energy.05-26-2011
20110125030MEDICAL DIAGNOSTIC DEVICE AND METHOD OF IMPROVING IMAGE QUALITY OF MEDICAL DIAGNOSTIC DEVICE - A medical diagnostic device is characterized in that an image processing means (05-26-2011
20100210952OPTICAL INSPECTION DEVICE, ELECTROMAGNETIC WAVE DETECTION METHOD, ELECTROMAGNETIC WAVE DETECTION DEVICE, ORGANISM OBSERVATION METHOD, MICROSCOPE, ENDOSCOPE, AND OPTICAL TOMOGRAPHIC IMAGE GENERATION DEVICE - An optical inspection device 08-19-2010
20110125031DEVICE AND METHOD FOR IN VIVO IMAGING - Devices and methods for optically scanning an in-vivo lumen, and for determining contact between an in-vivo device and an in-vivo lumen wall. The device may include an elongated housing having a cylindrical portion. At least one illuminating body may provide illumination at the circumference of the cylindrical portion, and at least one light sensor may sense light that penetrated and was scattered from the tissue of the in vivo lumen. The device may include means for preventing direct illumination from the illuminating body from reaching the light sensor and for decreasing the amount of direct light reflection from the outer surface of the in vivo lumen onto the light sensor.05-26-2011
20110178411METHOD FOR DETERMINING SKIN GLYCATION - A method for the measurement and analysis of skin fluorescence across multiple subjects. The method includes illuminating each subject with an excitation wavelength, detecting a peak fluorescence level within a corresponding emission wavelength range, determining relative levels of skin glycation for each subject, and evaluating the efficacy of a skin treatment based on the relative levels of skin glycation. The method can include ranking and normalizing the peak fluorescence levels for each subject, and the method is suitable for use in placebo-controlled studies of anti-glycation skin therapies.07-21-2011
20100056927SYSTEM, COMPUTER-READABLE MEDIUM, METHOD, AND USE FOR COMBINED EIPTHELIAL EARLY CANCER DIAGNOSIS AND STAGING03-04-2010
20110178409Optical Element - A microscope, endoscope or optical coherence tomograph, comprising a light source, a flexible light transmitter (07-21-2011
20100063403Therapeutic focused energy delivery - A method and an apparatus adapted to perform three dimensional (3D) position-tracking of a transducer unit comprising a three dimensional (3) target, the 3D target adapted to show a position of the transducer unit, and further adapted to facilitate tracking a tilt angle of the transducer unit; and an optical imager adapted to acquire a two dimensional (2D) target image of the target.03-11-2010
20100063402IMAGING SPECTROMETER FOR EARLY DETECTION OF SKIN CANCER - An imaging spectrometer provides substantially simultaneous areal spectroscopy and image generation to provide improved analysis of possible skin cancer.03-11-2010
20090216131USE OF SURFACE MOTION TO IDENTIFY MECHANICAL PROPERTIES OF BIOLOGICAL TISSUE - A method and apparatus to obtain information about the mechanical properties of a biological tissue by inducing periodic motion in the tissue, imaging the surface motion of the tissue under induced motion, processing the imaged surface motion to obtain descriptive metrics about the surface motion and relating one or more of these descriptive metrics to obtain information about the mechanical properties of the tissue.08-27-2009
20100056928DIGITAL LIGHT PROCESSING HYPERSPECTRAL IMAGING APPARATUS - A hyperspectral imaging system having an optical path. The system including an illumination source adapted to output a light beam, the light beam illuminating a target, a dispersing element arranged in the optical path and adapted to separate the light beam into a plurality of wavelengths, a digital micromirror array adapted to tune the plurality of wavelengths into a spectrum, an optical device having a detector and adapted to collect the spectrum reflected from the target and arranged in the optical path and a processor operatively connected to and adapted to control at least one of: the illumination source; the dispersing element; the digital micromirror array; the optical device; and, the detector, the processor further adapted to output a hyperspectral image of the target. The dispersing element is arranged between the illumination source and the digital micromirror array, the digital micromirror array is arranged to transmit the spectrum to the target and the optical device is arranged in the optical path after the target.03-04-2010
20100069759Method for the quantitative display of blood flow - A method for the quantitative representation of the blood flow in a tissue or vascular region is based on the signal of a contrast agent injected into the blood. Several individual images of the signal emitted by the tissue or vascular region are recorded and stored at successive points in time. For image areas of the individual images, the respective intensities of different points in time are compared and the maximum intensities of the signals are determined for these image areas. The maximum intensities are represented for these image areas.03-18-2010
20110077529Imaging apparatus - An imaging apparatus includes an illumination light output system that outputs light including wavelength components that are different from each other to living body tissue, an image formation optical system that forms an image of the living body tissue illuminated with the light output from the illumination light output system, and an imaging means that images the living body tissue. The image formation optical system has axial chromatic aberration in which focal length for C line that has a wavelength of 643.8 nm is greater than or equal to 102 when focal length for F line that has a wavelength of 486.1 nm is regarded as 100.03-31-2011
20110071402APPARATUS AND METHOD FOR IRRADIATING A MEDIUM - A method for irradiating a medium includes irradiating the medium with an electromagnetic wave which is scattered in the medium and modulated in frequency at a position in the medium; obtaining information corresponding to an interference pattern generated by interference between the modulated electromagnetic wave and a reference wave; and generating a phase conjugate wave, based on the obtained information, which irradiates the medium.03-24-2011
20120302892PORTABLE OPTICAL FIBER PROBE-BASED SPECTROSCOPIC SCANNER FOR RAPID CANCER DIAGNOSIS - A multimodal probe system for spectroscopic scanning of tissue for disease diagnosis. The system can use diffuse reflectance spectroscopy, fluorescence spectroscopy and Raman spectroscopy for the detection of cancerous tissue, such as tissue margin assessment.11-29-2012
20090018452PROBE ADAPTED TO MEASURE BIOLOGICAL SIGNAL - A probe is adapted to emit light having at least one wavelength as irradiation light with respect to a measured portion on a biological body in order to measure a biological signal. A light emitting element is configured to emit the light having the at least one wavelength. A light guiding member is provided with: a first end face, being light-reflective and having a first part opposing the light emitting element and a second part surrounding the first part; a second end face, being light-reflective and intersecting the first end face; and a third end face, being light-permeable, opposing the first end face and intersecting the second end face. The light guiding member is configured such that at least part of the light emitted from the light emitting element is reflected by at least one of the first end face and the second end face, and emitted from the third end face as the irradiation light. A light receiving element is configured to receive light reflected by the measured portion. A section shape of the first end face in a direction along an optical axis of the light emitting element is such a shape that at least the second part is coincident with a circumference of an ellipse intersecting a minor axis of the ellipse, and the optical axis of the light emitting element is coincident with the minor axis of the ellipse.01-15-2009
20100262018METHOD OF CONTROLLING A DEVICE FOR IMAGING THE INTERIOR OF TURBID MEDIA, DEVICE FOR IMAGING THE INTERIOR OF TURBID MEDIA AND COMPUTER PROGRAM PRODUCT - A method of controlling a device for imaging the interior of turbid media is provided. The device comprises: a receiving portion (10-14-2010
20110152693METHOD FOR PRECISELY DETERMINING THE FLUORESCENCE IN A LAYER SYSTEM, SUCH AS THE EYE - The invention relates to a method for precisely determining the fluorescence in a layer system, such as the eye. The object of the invention is to provide a method that is as simple and requires as little effort as possible for evaluating the fluorescence in a layer system, by means of which the summary decay behavior of the fluorescence can be evaluated very precisely, and by means of which the points of origin of the individual fluorescences of the layer system can be determined at the same time. According to the invention, the time of origin (tci) of each fluorescence in the individual layers of the layer system are determined in that layer-specific, time-dependent parameters are determined for the relevant fluorescences, said parameters each indicating the time of origin of the fluorescence in the relevant layer, and said parameters being considered in the model function for calculating the summary decay behavior of the fluorescence. Areas of application are found in the analysis of objects having layer structures, such as in biology, in medicine, and in production engineering.06-23-2011
20090292210TASK-LESS OPTICAL MAPPING OF BRAIN FUNCTION USING RESTING STATE FUNCTIONAL CONNECTIVITY - A method for utilizing an optical system for mapping brain function includes determining a time series of light intensity measurements for spatially distributed source and detector pairs, receiving light measurements over a period of time, and producing at least one map of a respective strength of each of a plurality of temporal correlations, wherein the temporal correlations are based on the time series of the spatially distributed source and detector pairs and the light measurements.11-26-2009
20120203114INTRINSIC AND SWEPT-SOURCE RAMAN SPECTROSCOPY - The present invention pertains to a method and an apparatus for Raman spectroscopy of human tissue. Human tissue is illuminated with a laser emitting a first wavelength of light. A Raman signal is measured and optical properties are determined at this wavelength such that the measured Raman signal can be corrected based on determined optical properties. Determined optical properties may be the scattering coefficient and absorption coefficient of the tissue. A system for Raman spectroscopy of human tissue includes a frequency sweeping laser light source for illumination, and a filtered detector for collecting the Raman signal.08-09-2012
20120203115SYSTEM AND METHOD FOR NONINVASIVE TISSUE EXAMINATION - A processing utility analyzes first measured data including at least two measured data pieces from at least two first spaced-apart measurement locations respectively within a first sub-region of the region of interest, and determines for each of the first locations a deviation parameter corresponding to deviation of the measured data piece from the reference response. The processing utility determines, for each of said at least two of the measured data pieces of the first measured data, a relation between the deviation parameter and a predetermined threshold value corresponding to a condition of said predetermined abnormality, and generate a corresponding control signal and communicate it to the measurement unit. The control signal is indicative of a first scan direction towards at least one second location to be measured in the region of interest where a degree of said predetermined abnormality is higher than in said at least two first locations.08-09-2012
20090118624DEVICE FOR ORAL CAVITY EXAMINATION - Described herein is a device used to perform examinations for detection of abnormal epithelial tissue, the device includes a handle portion, a housing and a mirror assembly secured to an end of the housing. The housing has first and second ends and is detachably connectable to the handle. The housing defines an interior and an opening that communicates the interior with an exterior of the housing when the handle and housing are connected.05-07-2009
20080287807GLOBAL MOTION INVARIANT SIGNATURES FOR FAST AND ACCURATE MOTION TRACKING IN A DIGITAL IMAGE-BASED ELASTO-TOMOGRAPHY SYSTEM - A method for converting digital images of an actuated breast into an accurate description of breast surface motion from a digital image-based elasto-tomography system comprises the steps of artificially placing a high density of fiducial markers on the breast surface, whereby the fiducial markers have different qualities and are placed in different proportions according to their quality; utilizing motion invariant properties of the fiducial markers to form a global motion invariant signature; tracking the markers on the actuated breast surface from image to image in each digital camera using the global motion invariant signature; and using the cameras calibration to measure the breast surface motion.11-20-2008
20090054787IMAGING SYSTEMS AND METHODS, PARTICULARLY FOR USE WITH MEDICAL INSTRUMENT USED IN OPEN SURGERY - Systems and methods for use in performing an open surgical procedure on a body of a patient using a working element of a surgical instrument that has a shaft connected proximally to the working element; and capturing an image of an area of the body using a camera that is connected to the shaft.02-26-2009
20080281207Image acquisition through filtering in multiple endoscope systems - A method of one aspect may include illuminating a surface with a broad bandwidth light from a first endoscope. The broad bandwidth light typically has a bandwidth of at least 200 nanometers (nm). A beam that includes at least one narrow bandwidth light may be scanned over the surface with a second, scanning beam endoscope. The narrow bandwidth light typically has a bandwidth of less than 3 nm. During the scanning, light that has been backscattered from the surface may be collected with the scanning beam endoscope. The collected backscattered light may be filtered with at least one narrow bandwidth band-pass optical filter. A band-pass bandwidth of the filter may be no more than 15 nm and may at least partially overlap the bandwidth of the narrow bandwidth light. The filtered backscattered light may be detected with a photodetector.11-13-2008
20090036783Biometric image pickup apparatus - A biometric image pickup apparatus includes: a light source section selectively switching between light of a first wavelength region with a high transmittance through a living organism and light of a second wavelength region with a lower transmittance through the living organism than light of the first wavelength region to apply the light of the first wavelength region and the light of the second wavelength region to the living organism; an image pickup lens section condensing light from the living organism; an image pickup device obtaining first image pickup data of the living organism on the basis of the light of the first wavelength region in light condensed by the image pickup lens, and obtaining second image pickup data on the basis of the light of the second wavelength region in the light condensed by the image pickup lens.02-05-2009
20080255461Real-time optical monitoring system and method for thermal therapy treatment - Multiple site information of light intensity is obtained by application of a multiple-fibre probe in a real-time optical monitoring system. The multiple-fibre probe includes a plurality of optical fibres distributed along the length of the probe. Each optical fibre may be is switchable between the mode for transmitting optical signal into the malignant tissue and the mode for collecting the optical signal from the same tissue. Thus the numbers of the probes can be minimized for collecting multiple site light information and the irritation to the tissue is reduced. A method of using such a probe to determine coagulated boundary in thermal or other treatment is also described.10-16-2008
20080255460NANOPARTICLE TISSUE BASED IDENTIFICATION AND ILLUMINATION - Various compositions, methods, and devices are provided that use fluorescent nanoparticles to function as markers, indicators, and/or light sources. In an exemplary embodiment, the fluorescent nanoparticles are biocompatible, and more preferably they can be formed from a fluorophore core surrounded by a biocompatible shell, such as a silica shell. In one aspect, the fluorescent nanoparticles can be delivered to tissue to mark the tissue, enable identification and location of the tissue, and/or illuminate an area surrounding the tissue.10-16-2008
20080255457Method For Evaluating Relative Oxygen Saturation in Body Tissues - A new method was discovered to analyze continuous spectral curves to determine relative hemoglobin oxygen saturation, using spectral curves collected from a continuous range of wavelengths from about 530 nm to about 584 nm, including spectra from transmitted or reflected light. Using isosbestic points and curve areas, a relative saturation index was calculated. With this method, noninvasive, in vivo measurement of relative oxygen saturation was made using light reflected from blood vessels in the eye and to map and measure relative changes in hemoglobin oxygen saturation in primate retinal vessels and optic nerve head in response to controlled changes in inspired oxygen and intraocular pressure (IOP). This method could also measure oxygen saturation from other blood vessels that reflect light sufficient to give a clear spectra from the blood hemoglobin. Changes in blood oxygen saturation can be monitored with this method for early detection of disease.10-16-2008
20080255459SENTINEL NODE IDENTIFICATION USING FLUORESCENT NANOPARTICLES - Various compositions, methods, and devices are provided that use fluorescent nanoparticles, which can function as markers, indicators, and light sources. The fluorescent nanoparticles can be formed from a fluorophore core surrounded by a biocompatible shell, such as a silica shell. In one embodiment, the fluorescent nanoparticles can be delivered to tissue to mark the tissue, enable identification and location of the tissue, and/or illuminate an area surrounding the tissue. In another embodiment, the fluorescent nanoparticles can be used on a device or implant to locate the device or implant in the body, indicate an orientation of the device or implant, and/or illuminate an area surrounding the device or implant. The fluorescent nanoparticles can also be used to provide a therapeutic effect.10-16-2008
20100292581Dynamic Calibration of an Optical Spectrometer - A dynamically calibrating optical spectrometer and method for dynamically calibrating the optical spectrometer are provided. The optical spectrometer may include a band-pass device and a device that scans, such that a scan window can be widened, and the edges of the band-pass device can be used to calibrate out drifts in the system. The optical spectrometer may be for acquiring and analyzing a spectroscopic sample of an analyte from a sampling region of the tissue of a person. The optical spectrometer includes a tunable source of electromagnetic radiation, a probe for delivering the electromagnetic radiation to the tissue at the sampling region and obtaining a diffuse reflectance signal from the tissue at the sampling region, a spectroscopic detector for analyzing the diffuse reflectance signal for presence of the analyte, and a wavelength calibration detector for calibrating the tunable source of electromagnetic radiation to a desired wavelength.11-18-2010
20100292580SEPTIC BARRIERS AND OTHER AIDS FOR AUTOFLUORESCENCE VISUALIZATION AND OTHER OPTICAL INTERROGATION - Septic barriers interposed between a target tissue such as an oral or vaginal cavity, exposed epidermis, or wound or surgical site, and a user and his/her optical interrogation instruments to reduce cross-infection and/or contamination. In certain embodiments, the septic barrier is substantially transparent for viewing purposes and is typically effectively non-fluorescent, particularly when used for investigating autofluorescence or other fluorescence emanating from a target, so as to have little or no effect on the measurements and observations being made. The sepsis barrier can comprises a window through which the user sees the tissue, a frame holding the window, and an attachment structure, such as threads or bayonet attachment, configured to connect the barrier to the instrument. If desired, the system can also have an optional attachment mechanism for permanent or temporary connection of a further instrument to the frame, such as a tissue retractor configured to aid manipulation of the target tissue.11-18-2010
20110118610AN OPTICAL IMAGE PROBE - The invention relates to an optical image probe(05-19-2011
20120150045ENDOSCOPE SYSTEM FOR FLUORESCENT OBSERVATION - An endoscope system is disclosed for detecting fluorescent light emitted in the near-infrared region by a plurality of fluorescent labeling materials introduced into a living tissue. An illumination system generates illumination light in the wavelength range 600 nm-2000 nm which serves as excitation light for the plurality of fluorescent labeling materials, and a detection system that can separately detect different ones of the plurality of fluorescent light emissions that are emitted at different wavelengths from among the plurality of fluorescent labeling materials is provided. The endoscope system may include a conventional-type endoscope having an insertion section, or a capsule endoscope that wirelessly transmits image data. By superimposing the image data obtained using reflected light in the visible region and fluorescent light emitted by the fluorescent labeling materials, improved diagnostic capabilities are provided.06-14-2012
20100305455DEVICE FOR WAVELENGTH-SELECTIVE IMAGING - An imaging device captures both a visible light image and a diagnostic image, the diagnostic image corresponding to emissions from an imaging medium within the object. The visible light image (which may be color or grayscale) and the diagnostic image may be superimposed to display regions of diagnostic significance within a visible light image. A number of imaging media may be used according to an intended application for the imaging device, and an imaging medium may have wavelengths above, below, or within the visible light spectrum. The devices described herein may be advantageously packaged within a single integrated device or other solid state device, and/or employed in an integrated, single-camera medical imaging system, as well as many non-medical imaging systems that would benefit from simultaneous capture of visible-light wavelength images along with images at other wavelengths.12-02-2010
20100324426Full-Body Laser Scanner and Method of Mapping and Contouring the Body - A full-body non-invasive laser scanner for mapping or measuring a patient's body and for treating a patient's body with laser energy comprises a patient support, one or more laser devices, a laser guidance system, a control center, and optionally feedback sensors. The patient support aids in maintaining body alignment during treatment, and the laser devices are moveably positioned on a laser guidance system such that they can be driven about a stationary patient. To map and contour a patient's body, the patient aligns himself on the patient support. With the control center, an operator chooses whether to map, contour, or map and contour the patient's body either manually or according to preprogrammed treatment protocols. The carriage assembly translates and the laser devices apply laser energy to the surfaces of the patient's body according to the chosen protocol. Feedback sensors provide data for mapping the contours of the patient's body.12-23-2010
20110087109METHODS AND APPARATUS FOR DETERMINING FALLOPIAN TUBE OCCLUSION - Devices and methods for determining fallopian tube occlusion. The methods may include determining fallopian tube occlusions through a pressurization or volumetric determination.04-14-2011
20100179436OPTICAL SYSTEM FOR DETECTION AND CHARACTERIZATION OF ABNORMAL TISSUE AND CELLS - An optical system and apparatus for the diagnosis of a biological sample is disclosed. An embodiment of the apparatus includes an optical probe, a probe head distally connectable to the optical probe, the optical probe further comprising at least one optical clement for applying an electromagnetic radiation of a first wavelength to the biological sample, and one or more collection elements positioned proximate the at least one optical element; and an analyzer for analyzing a signal received from the biological sample by the one or more collection elements.07-15-2010
20110257533BIOLOGICAL INFORMATION MEASUREMENT DEVICE, ILLUMINATION METHOD IN A BIOLOGICAL INFORMATION MEASUREMENT DEVICE, AND BIOLOGICAL INFORMATION MEASUREMENT METHOD - A biological information measurement device that measures biological information of a user includes: a device main body; a fitting-removal section which is provided in the device main body, and to/from which a sensor that measures the biological information is fitted/removed; a light source section that is provided within the device main body at a position spaced apart from the fitting-removal section and that functions as a light source for components of the biological information measurement device other than the fitting-removal section; and a light guide member that guides light emitted by the light source section to a predetermined position in the vicinity of the fitting-removal section to/from which the sensor is fitted/removed.10-20-2011
20100121200DIAGNOSTIC AND PROGNOSTIC ASSISTANCE DEVICE FOR PHYSIOPATHOLOGICAL TISSUE CHANGES - Said device applies in particular to in vivo diagnostic and prognostic assistance for physiopathological changes to biological tissues. It comprises a coherent light source (05-13-2010
20100121198Multi-Purpose Illumination System And Method For Tissue Examination - The present invention is a multi-purpose light source of a unique design and specialized attachments. The invention encompasses a system for the illumination and visual detection of normal and abnormal biologic tissue comprising a light source, a light transmitting device and a light viewing device wherein said device allows for the simultaneous illumination and viewing of target tissue.05-13-2010
20100121199Method and apparatus for non-invasive cancerous tissue diagnosis and tomography using terahertz image - The primary objective of the present method and apparatus is to provide a portable and new diagnosis system for quickly and reliably examining tissue conditions. The method uses the most advance miniaturized micro-opto-electro-mechanical systems (MOEMS) system for generating a rapid variable optical delay line to be able of generating wideband terahertz pulses. The method detects and analyzes cancerous tissues by comparing a plurality of spectrum resolved images of suspected tissue without applying harmful agents into the tissue to facilitate interaction with illumination sources. The method employs non-evasive, real time terahertz imaging systems and techniques to diagnose tissue for detecting the presence of cancer. A map showing, which tissue is healthy and which is cancerous can aid in the accurate removal of cancerous tissue.05-13-2010
20110137178Devices and methods for imaging particular cells including eosinophils - An exemplary embodiment of apparatus and method according to the present disclosure can be provided. For example, using at least one first arrangement, it is possible to direct at least one first electro-magnetic radiation to at least one portion of tissue within a body. Using at least one second arrangement, it is possible to receive at least one second electro-magnetic radiation provided from the portion, which is based on the first electro-magnetic radiation. Further, using at least one third arrangement, it is possible to differentiate at least one particular cell which is eosinophil, mast cell, basophil, monocyte and/or nutrophil from other cells in the portion based on the second electro-magnetic radiation.06-09-2011
20110071403FUNCTIONAL NEAR-INFRARED FLUORESCENCE LYMPHATIC MAPPING FOR DIAGNOSING, ACCESSING, MONITORING AND DIRECTING THERAPY OF LYMPHATIC DISORDERS - Methods and imaging agents are used to functionally image lymph structures and to identify, diagnose, assess, monitor and direct therapies for lymphatic disorders. Embodiments of the methods utilize highly sensitive optical imaging and fluorescent spectroscopy techniques capable of rapid temporal resolution to non-invasively track or monitor packets of imaging agents flowing in one or more lymphatic structures in human patients to provide quantitative information regarding lymph propulsion and functionality of the lymphatic structures. An imaging agent comprises a fluorophore labeled peptide capable of binding integrin α03-24-2011
20110087111System and Method for Normalized Diffuse Emission Epi-illumination Imaging and Normalized Diffuse Emission Transillumination Imaging - A system and method provide normalized fluorescence epi-illumination images and normalized fluorescence transillumination images. The normalization can be used to improve two-dimensional (planar) fluorescence epi-illumination images and two-dimensional (planar) fluorescence transillumination images. The system and method can also provide normalized bioluminescence epi-illumination images and normalized bioluminescence transillumination images. In some arrangements, the system and method can provide imaging of small animals, intro-operative imaging, endoscopic imaging, and/or imaging of hollow organs.04-14-2011
20110178410Method of Quantitative Analysis Utilizing Multiphoton Microscopy - The present invention utilizes multiphoton microscopy for a quantitative analysis of a bio tissue or a skin. Multiphoton microscopy is characterized in low invasion, low photo damage and high penetration. Hence, scanning through multiphoton microscopy does not hurt the bio tissue. It is thus fit for scanning live bio tissues to know its aging status. In addition, the quantitative analysis provides a precise index for diagnosing a damage severity of the tissue, like cancer.07-21-2011
20110190639Bi-Spectral Peroperative Optical Probe - Optical probes for medical applications are provided. The probe is devised so as to be able to be held in one hand. A basic version of the probe includes: a first excitation lighting source suitable for causing a fluorescence radiation of predetermined substances; a second visible lighting source, the first and the second source being devised so as to illuminate a common zone termed the intervention zone; a first photosensitive matrix sensor; and a second photosensitive matrix sensor. The first and second photosensitive matrix sensors are devised in such a way that, when the optical probe is arranged a predetermined distance from the intervention zone, the image in the visible spectrum of the said zone is formed on the photosensitive surface of the first matrix sensor and the image in the fluorescence spectrum of the said zone is formed on the photosensitive surface of the second sensor. A first variant of the probe includes only a single optical objective, a second variant only a single photosensitive matrix sensor, and a third variant makes it possible to work under polarized light.08-04-2011
20100241007Precision measuring system - A non-invasive imaging and analysis method and system/apparatus suitable for non-invasive imaging and analysis of a target is disclosed. Targets include biological tissue structures or components; optical structures or components; electronic structures or components; or structures in general. A preferred embodiment of the invention provides a precision optical measuring module that modifies the spatial separation of multiple reference interference signals by adjusting the separation between a partial reflective element and a full mirror mounted on a piezo device and determining the distance between surfaces or structures within the target by simultaneously monitoring the magnitude of the separation between the partial reflective element and the full mirror and processing generated interference signals. Techniques for simultaneously monitoring the magnitude of the separation between the partial reflective element and the full mirror include conventional measurement techniques, such as, capacitive, optical, or strain techniques or alternatively the use of one or more etalons. Another embodiment of the invention provides a system and method of precisely measuring the position of a surface of interest.09-23-2010
20120150043SYSTEMS AND METHODS FOR GENERATING FLUORESCENT LIGHT IMAGES - An imaging system divides image pixels intensities by exposure time to generate image data in units of intensity per time. The imaging system divides a fluorescent light image in intensity per time units by an excitation light image in intensity per time units to provide a quantitative corrected fluorescent light image that is generally invariant to position of an imaging instrument relative to a biological tissue being imaged.06-14-2012
20110190637MEDICAL MEASURING SYSTEM, METHOD FOR SURGICAL INTERVENTION AS WELL AS USE OF A MEDICAL MEASURING SYSTEM - The invention relates to a medical measuring system, surgical intervention methods, and the use of a medical measuring system. The measuring system comprises two two-dimensional imaging sensors, a light source that is rigidly connected to the camera system in order to project structured light onto objects, and a structure that has a two-dimensional pattern and is mounted on an object.08-04-2011
20110190638Illumination Apparatus for Use in Examining a Body of Living Tissues - An illumination apparatus for use in examining a body of living tissues, the apparatus comprising a head for contacting the body of living tissues, a light source mounted in the head for illuminating the tissues, and an annular switch disposed around the light source, the annular switch being adapted automatically to permit illumination of the light source at an examination intensity when the head contacts the body at least around an annular contact area on the head corresponding to the annular switch.08-04-2011
20110201941OPTICAL SCANNING PROBE ASSEMBLY - The present invention relates to an optical scanning probe assembly for microscopic guide optic scanning and inspection of tissues suitable for application in, e.g. in vivo medical inspection and biopsy. The assembly comprises an outer housing (08-18-2011
20110201939METHODS AND SYSTEMS FOR GUIDING AN EMISSION TO A TARGET - Disclosed are methods and systems for guiding emissions to a target. The methods and systems utilize, in part, Markerless Tracking software to detect a beam of energy, such as a laser, toward a target such as a tissue that is the subject of a medical procedure.08-18-2011
20100030084DIFFUSE OPTICAL TOMOGRAPHY WITH MARKERS CONTAINING FLUORESCENT MATERIAL - The invention relates to a system, a medical image acquisition system, and a method for imaging an interior of a turbid medium (02-04-2010
20100022892METHOD AND DEVICE FOR NEURAL USER INTERFACE AND BRAIN ACTIVITY MEASURING DEVICE FOR THE SAME - Disclosed are a brain activity measuring device for determining the user's intention by analyzing brain activities, and a neural user interface (NUI) device including an interface section for executing the user-intended function understood in the brain activity measuring device and outputting the result, wherein the brain activity measuring device includes; a light irradiating section for irradiating photons to the cerebral cortex; a light detecting section for detecting the photons emitted out of the human body after the interaction with the cerebral cortex and detecting a change in physical properties of the photons; and an analyzing section for analyzing the change in physical properties of the photons detected in the light detecting section and generating brain activity data to determine the user's intention.01-28-2010
20100016732APPARATUS AND METHOD FOR NEURAL-SIGNAL CAPTURE TO DRIVE NEUROPROSTHESES OR CONTROL BODILY FUNCTION - Method and apparatus for detecting nerve activity of an animal. Some embodiments include outputting a light pulse having a wavelength onto a volume of animal tissue such that the light pulse interacts with active nerves of the tissue; measuring a light signal resulting from the interaction of the light pulse with the tissue; transmitting an electrical signal based on the measured light signal; signal-processing the electrical signal; and outputting a response signal, which can optionally be used to control a prosthetic device, stimulate another nerve, or display/ diagnose a condition. Some embodiments output a plurality of light wavelengths and/or pulses, which are optionally high-frequency intensity modulated. Some embodiments analyze DC, AC, and phase components of signals to spatially resolve locations of neural activity. Some embodiments output light pulse(s) and detect the resultant light from outside a human skull to detect neural activity of human brain tissue inside the skull.01-21-2010
20100016731Hemodynamic Detection of Circulatory Anomalies - The preferred indicator is an injection of indocyanine green dye which is detected and quantified by causing it to fluoresce at a sensor location, for example, at the human ear. Quantification is carried out by using cardiac output procedures and where called for, the Valsalva Maneuver is monitored at a monitor/controller giving visual cues to the patient and operator as to the quality of the necessary exhalation pressure maintenance.01-21-2010
20100160791PORCINE BILIARY TRACT IMAGING - The present invention includes apparatus and method to prevent surgical injury. The invention incorporates near infrared (NIR) spectroscopy, which capitalizes on near infrared light's ability to penetrate deeply into tissues and spectroscopic capability to discern tissue's chemical properties. The present invention further characterized the NIR optical properties of bile containing structures as a clinically useful probe.06-24-2010
20090005691METHODS AND SYSTEMS FOR BLOOD FLOW MEASUREMENT USING DOPPLER OPTICAL COHERENCE TOMOGRAPHY - This invention provides methods for non-invasive, real-time measuring and/or monitoring of local blood flow in a subject. Methods of the invention generally include the steps of obtaining Doppler shift images of at least two planes intersecting blood vessels at the scanned location; determining Doppler angles using the Doppler shift images; and then using the Doppler angles thus determined together with the Doppler shift signals to arrive at a measure of the volumetric blood flow. Also provided are systems and software for performing the methods.01-01-2009
20110306887SYSTEM AND METHOD FOR DETERMINING TISSUE CHARACTERISTICS - A method and apparatus are provided that interrogate, receive, and analyze full emission spectra for at least one fluorescence excitation wavelength and for at least one reflectance measurement to determine tissue characteristics. The method includes illuminating a first portion of a target tissue with optical energy, forming a first image of the target tissue, illuminating a second portion of the target tissue with optical energy, performing spectroscopic measurements on optical energy reflected and/or emitted by the target tissue upon illumination of the second portion of the target tissue with optical energy, and determining tissue characteristics of the target tissue based on the results of the spectroscopic measurements. The apparatus and system include a base unit having illumination, detection and control sub-units, the illumination sub-unit providing illumination optical energy for illuminating a target tissue and the detection sub-unit detecting tissue characteristics of a target tissue, a separate tissue interface unit, and a pathway coupling the base unit and the tissue interface unit. The system and apparatus may also include a tissue interface unit configured to perform spectroscopic measurements on a target tissue, a docking unit configured to support the tissue interface when not in use, the docking unit including an illumination source and a processor that processes spectrographic measurements results received from the tissue interface unit, and a pathway coupling the docking unit and the tissue interface unit.12-15-2011
20080262359SYSTEM AND METHOD PROVIDING INTRACORONARY LASER SPECKLE IMAGING FOR THE DETECTION OF VULNERABLE PLAQUE - Apparatus and method according to an exemplary embodiment of the present invention can be provided for analyzing tissue. For example, the apparatus can include at least one first arrangement configured to illuminate at least one anatomical structure with at least one of at least one electro-magnetic radiation. The apparatus can also include at least one second arrangement that may include at least two wave-guiding arrangements associated with one another that are configured to receive a further electro-magnetic radiation reflected from the tissue and transmit at least one speckle pattern associated with the further electro-magnetic radiation. The wave-guiding arrangements may be structured so as to reduce crosstalk therebetween.10-23-2008
20100179435NONINVASIVE MEASUREMENT OF FLAVONOID COMPOUNDS IN BIOLOGICAL TISSUE - Methods and apparatus are disclosed which facilitate the rapid, noninvasive and quantitative measurement of the concentration of flavonoid compounds, as well as their isomers and metabolites, in biological tissue such as human skin. Low-intensity, visible-light illumination of intact tissue provides for high spatial resolution, and allows for precise quantification of the flavonoid levels in the tissue. The preferred embodiments malce use of a previously unknown, low-oscillator strength, optical absorption transition of flavonoids. This malces it possible to optically excite flavonoids in living human tissue outside the absorption range of other, potentially confounding skin chromophores. A system constructed in accordance with the invention includes a source of light for illuminating a localized region of tissue with light that overlaps the absorption bands of a flavonoid compound; a device for detecting the fluorescence emitted by the flavonoid compound resulting from the illumination; and a processor for determining the concentration level of the flavonoid compound based upon the detected fluorescence.07-15-2010
20110112408Optical Speculum - A system for direct imaging and diagnosing of abnormal cells in a target tissue includes a disposable optical speculum and an image acquisition system having the speculum assembled on and mechanically secured thereto. The image acquisition system is arranged to capture at least one of a single image or multiple images or video of cells within the target tissue using at least one of bright field or dark field ring illumination divided into independently operated segments to obtain a plurality of data sets. An image analysis and control unit in communication with the image acquisition system analyzes the data sets and applies algorithms to the data sets for diagnosing abnormal cells.05-12-2011
20120041315Fluorescence Lifetime Spectrometer (FLS) and Methods of Detecting Diseased Tissue - This invention relates to method and apparatus for collection of the complete fluorescence emission spectrum and the transient decay of a selected spectral band simultaneously with data acquisition times of less that one second. This invention is useful for studying human tissues and cells in vivo.02-16-2012
20110021925Mounted vein contrast enchancer - A vein-image-enhancing system transmits two different wavelengths of laser light, being directed by a steering means, to form a raster pattern on a target. Reflected light comprises a contrasted image formed by a portion of the first wavelength being absorbed by veins, and a portion of that first wavelength being reflected from the target. A photodectector sensitive to the first wavelength captures reflected light. The contrasted image is projected onto the target to illuminate vein locations using the second wavelength, which comprises visible light. Projection may operate according to one of three modes: the alternating frame mode, a dual buffer mode, and real time mode. The AFM and DBM modes incorporate analog to digital converters and digital memory for timed projection onto the target. The vein enhancer may be specially attached to different platforms—hospital bed, IV stand, wheelchair, etc., to enable convenient use of the enhancer on a patient.01-27-2011
20100305453IMAGING OF LIGHT SCATTERING TISSUES WITH FLUORESCENT CONTRAST AGENTS - A system and method for non-invasive biomedical optical imaging and spectroscopy with low-level light is described. The technique includes a modulated light source coupled to tissue to introduce excitation light. Fluorescent light emitted in response to the excitation light is detected with a sensor. The AC intensity and phase of the excitation and detected fluorescent light is provided to a processor operatively coupled to the sensor. A processor employs the measured emission kinetics of excitation and fluorescent light to “map” the spatial variation of one or more fluorescence characteristics of the tissue and generate a corresponding image of the tissue via an output device. The fluorescence characteristic may be provided by exogenous contrast agents, endogenous fluorophores, or both. A technique to select or design an exogenous fluorescent contrast agent to improve image contrast is also disclosed.12-02-2010
20120046555BODY TISSUE IMAGING USING RAMAN SCATTERING LIGHT - An object of the present invention is to provide a method for the noninvasive imaging of a tissue (in particular, a cardiac tissue) in real time, and a device therefor. The present invention provides a method for imaging a sample that contains myocardial tissue and one or more blood vessels and/or one or more collagen-rich regions, the method comprising the steps of: (1) irradiating the sample that contains myocardial tissue and one or more blood vessels and/or one or more collagen-rich regions with an excitation light; (2) detecting Raman scattering light from the sample; and (3) analyzing the thus obtained Raman scattering light by using Raman scattering spectra that are characteristic of myocardial cells and red blood cells and/or collagen as indexes and thus imaging the sample.02-23-2012
20120004557METHOD AND SYSTEM FOR FLUORESCENT IMAGING WITH BACKGROUND SURGICAL IMAGE COMPOSED OF SELECTIVE ILLUMINATION SPECTRA - A surgical site is simultaneously illuminated by less than all the visible color components that make up visible white light, and a fluorescence excitation illumination component by an illuminator in a minimally invasive surgical system. An image capture system acquires an image for each of the visible color components illuminating the surgical site and a fluorescence image, which is excited by the fluorescence excitation component from the illuminator. The minimally invasive surgical system uses the acquired images to generate a background black and white image of the surgical site. The acquired fluorescence image is superimposed on the background black and white image, and is highlighted in a selected color, e.g., green. The background black and white image with the superimposed highlighted fluorescence image is displayed for a user of the system. The highlighted fluorescence image identifies tissue of clinical interest.01-05-2012
20120209124BREAST HEALTH CARE DEVICE - The present invention relates to a breast health care device, which comprises: a main body, which comprises at least one cover portion; and at least one node module, which is disposed on the cover portion. The node module comprises a light-emitting unit, a photo detector, or the combination thereof, wherein the light-emitting unit provides a light of predetermined wavelength to a breast tissue, and the photo detector detects a first signal generated from the breast tissue. Thus, users can directly achieve detection for the health condition of breasts by wearing the bra of the disclosed breast health care device of the present invention, and the disclosed health care device can transmit the detection results to an external health-care platform such as hospitals or medical centers immediately.08-16-2012
20120209125Singlet Oxygen Production and Dosimetry for Photodynamic Therapy - An apparatus for photodynamic therapy (PDT) includes a light source configured to provide excitation light for a photosensitizer, an optical system configured to direct the excitation light to a target region and receive light emitted by the photosensitizer and/or singlet oxygen generated in the target region, and a detection system configured to receive the light emitted by the photosensitizer and/or the singlet oxygen. The apparatus also includes a filter system configured to spectrally discriminate between emission from the photosensitizer and the singlet oxygen and a processor configured to determine concentrations of the singlet oxygen and/or the photosensitizer based on an emission signal measured by the detection system.08-16-2012
20110098577REGISTRATION POINTER AND METHOD FOR REGISTERING A BONE OF A PATIENT TO A COMPUTER ASSISTED ORTHOPAEDIC SURGERY SYSTEM - A registration pointer includes a camera located in an elongated shaft having a distal end configured to be contacted to a bone of a patient to register the bone to a computer assisted orthopaedic surgery system. The camera may be a hemispherical camera and may include a panoramic camera and a wide-angle camera equipped with a fish-eye lens. The registration pointer is configured to transmit images received by the cameras to the computer assisted orthopaedic surgery system for display thereon. The computer assisted orthopaedic surgery system may be configured to generate an image, such as a hemispherical image, based on the images received from the registration pointer.04-28-2011
20110098576NON-INVASIVE IMPLANT RUPTURE DETECTION SYSTEM - Devices and methods for non-invasive implant rupture detection are described herein. Some variations of a non-invasive implant rupture detection device comprise a single optical waveguide, such as a silicone fiber, embedded in the shell of the implantable device where one end of the optical waveguide is connected to a photo emitter and the other end of the waveguide is connected to photo detector. An optical signal successfully transmitted from the photo emitter through an intact optical waveguide to the photo detector indicates that the implant shell is intact, while an optical signal that is transmitted by the photo emitter, but not detected by the photo detector, indicates that there is a discontinuity or rupture in the shell. The status of the implant shell is wirelessly communicated to an external reader and provided to a patient and/or a practitioner.04-28-2011
20120310098LASER ENHANCED RECONSTRUCTION OF 3D SURFACE - A method for reconstructing a surface of a three-dimensional object (12-06-2012
20120310097SURGICAL IMAGING DEVICE - A surgical imaging device includes at least one light source for illuminating an object, at least two image sensors configured to generate image data corresponding to the object in the form of an image frame, and a video processor configured to receive from each image sensor the image data corresponding to the image frames and to process the image data so as to generate a composite image. The video processor may be configured to normalize, stabilize, orient and/or stitch the image data received from each image sensor so as to generate the composite image. Preferably, the video processor stitches the image data received from each image sensor by processing a portion of image data received from one image sensor that overlaps with a portion of image data received from another image sensor.12-06-2012
20120065520OPTICAL MEASUREMENT APPARATUS - An optical measurement apparatus has a light source section, a light receiving section, and a light guiding section. The light source section has a light emitting surface that emits light. The light receiving section has a light receiving surface that receives the light emitted by the emitting surface of the light source to be incident into a body through a surface of the body and which is emitted out of the body after propagating inside the body, the receiving surface facing a direction orthogonal to the emitting surface of the light source, and the receiving section outputting a signal indicative of an amount of the light received by the receiving surface. The light guiding section is provided on a path of the light emitted from the emitting surface and received by the receiving surface to change a traveling direction of the light.03-15-2012
20120059266IMAGING METHOD - A docking station for use in combined imaging of a tissue wound and a test substrate comprising a sample from a tissue wound, the docking station comprises means for connecting the station to a processor which processes and stores the images. The docking station also incorporates means for receiving a test substrate comprising a sample from a tissue wound. The docking station also includes means for docking a sensor in the station, which sensor detects the light reflected from an illuminated tissue wound, such that an image of the tissue wound can be communicated from the station to the processor. The means for docking is arranged such that when the sensor is docked in the station and the test substrate is received by the docking station, the sensor is positioned to detect the intensity of reflected light from the test substrate and communicates the detected intensity of reflected light to the processor to thus permit combined imaging of the tissue wound and test substrate. An apparatus for use in combined imaging of a tissue wound and a test substrate comprising a sample from a tissue wound, comprises such a docking station together with a sensor which detects the light reflected from a tissue wound and test substrate when illuminated and a test substrate for receiving a sample from a tissue wound. A method of imaging a wound comprises directing light over a wavelength range of less than 50 nm onto the wound (03-08-2012
20120016245PLETHYSMOGRAM SENSOR - The plethysmogram sensor disclosed in this specification includes a light emitting portion whose output is variable, a light receiving portion to detect a light emitted from the light emitting portion and penetrates a living body of a measured person, and a processing unit to acquire information about the plethysmogram of the measured person based on a measured value provided from the light receiving portion.01-19-2012
20120209123Surgeon's Aid for Medical Display - A system for identifying an area of interest on a surgical image, including a source of surgical image data, which may be a camera, an image processing unit, which may be a camera control unit, and a destination, which may be a display. The image processing unit is configured to receive the surgical image data and combine it with an overlay pattern for identifying an area of interest, which is then displayed on the display. The overlay may include a key with coordinates or labels. Properties of the overlay and the key may be customized and adjusted.08-16-2012
20110087110MEDICAL IMAGING PROCESSES FOR FACILITATING CATHETER-BASED DELIVERY OF THERAPY TO AFFECTED ORGAN TISSUE - Medical imaging processes are disclosed for facilitating the catheter-based delivery of stem cells or other therapy to affected organ tissue, including myocardial infarct and peri-infarct tissue. The disclosed processes include the integration of static image data showing the affected tissue with a live/moving image (e.g., a fluoroscopy image) to generate a hybrid view showing the real time location of an injection catheter relative to the affected tissue. The static image data may include or be derived from one or more noninvasive nuclear medicine imaging scans (e.g., PET or SPECT) generated prior to the catheterization procedure. The live image may also be augmented with visual markers showing target and/or actual injection locations. Also disclosed are methods for calculating amounts of therapy to deliver to the affected tissue.04-14-2011
20120022380METHODS AND APPARATUS FOR ASSESMENT AND TREATMENT OF BODY CAVITIES - Methods and apparatus for detection, assessment and optionally treatment of the cancerous tissue in the natural and manmade body cavities. An expandable cavity assessment device that is coupled with cancer detecting elements is placed in a cavity in close proximity to the site of cancerous tissue. The cavity assessment device may receive an optical fiber, or other type of energy conduit and potentially a radioactive source for interstitial radiation therapy. The cavity assessment device may be equipped with a balloon member coupled with electro conductive elements. Further, a system facilitating substance communication with the internal surface of the cavity is provided.01-26-2012
20090137908MULTI-SPECTRAL TISSUE IMAGING - Apparatus and methods are disclosed for multi-spectral imaging of tissue to obtain information about the distribution of fluorophores and chromophores in the tissue. Using specific spectral bands for illumination and specific spectral bands for detection, the signal-to-noise ratio and information related to the distribution of specific fluorophores is enhanced as compared to UV photography, which uses a single RGB image. Furthermore, the chromophore distribution information derived from the multi-spectral absorption images can be used to correct the fluorescence measurements. The combined fluorescence, absorption, and broadband reflectance data can be analyzed for disease diagnosis and skin feature detection.05-28-2009
20120065522Patient Monitoring Apparatus - A patient monitoring system including a sensing-recording device that attaches to a patient and a probe utilized by attending personnel at a trauma site. After an initial interaction between the probe and the sensing-recording device, the sensing-recording device samples one or more physiological parameters and stores time stamped readings in a first memory. The probe is adapted to take other measurements, download the data from the first memory of the sensing-recording device, manipulate the collective data and return data to a second memory in the sensing-recording device. The sensing-recording device continues to accumulate data in the first memory during transport of the patient from a trauma, site to a medical facility.03-15-2012
20120065521NEEDLE BIOBSY IMAGING METHOD - Imaging techniques. Radiation is directed from a source onto a sample using an endoscope having cellular or subcellular resolution. The endoscope includes one or more fibers. The fibers have a proximate end and a distal end, and the distal end is lensless. A focal plane of the endoscope is substantially at a tip of the distal end. Radiation from the sample is directed onto a detector to diagnose or monitor the sample.03-15-2012
20120065519METHOD AND SYSTEM FOR COLLECTING OPTICAL DATA FOR USE IN TIME RESOLVED OPTICAL IMAGING OF A TURBID MEDIA - There is provided a method and a system for collecting optical data for use in time resolved optical imaging wherein excitation light of a tunable wavelength is directionally propagated to impinge on a plurality of illumination points at the surface of a region of interest in a turbid media, comprising for example a biological tissue such as that comprised in small animals or in human organs. Light re-emitted with a different wavelength from a fluorescent marker present in the tissue is collected and directionally propagated towards a detector. A filter located in a path of the light rejects photons outside a fluorescence emission spectrum of the fluorescent marker while maintaining selectivity of the re-emitted light. The detector produces time resolved optical signals useful for optical image reconstructions.03-15-2012
20110098575METHOD AND AN ARRANGEMENT FOR THE DETERMINATION OF THE OPTICAL PROPERTIES OF A MULTI-LAYERED TISSUE - The present invention relates to a method and an arrangement for the determination of the optical properties of a multi-layered tissue. More specifically, the invention relates to a method for the detection and characterization of tumors in a tissue.04-28-2011
20110092823System and Method for Identifying Tissue Using Low-Coherence Interferometry - An apparatus for needle biopsy with real time tissue differentiation using one dimensional interferometric ranging imaging, comprising a biopsy device having a barrel and a needle, an optical fiber inserted in the needle, and a fiber optic imaging system connected to the optical fiber. The imaging system obtains images and compares the optical properties and patterns to a database of normalized tissue sample images to determine different tissue types. The physician performing the biopsy obtains feedback via a feedback unit associated with the biopsy device and which is connected to the imaging system. The feedback unit can provide visual, audible or vibratory feedback as to tissue type encountered when the needle is inserted toward the target tissue. The feedback unit can be programmed for different biopsy procedures so that the user can actuate a button to select a display or other feedback mechanism for the desired procedure and anticipated tissue to be encountered.04-21-2011
20120071765Digital Mapping System and Method - Embodiments of the innovation relate to method for generating an image of a tissue element. The method includes generating, by a visualization system controller, a highlighting image representation of the tissue element within a tissue region based upon a first image of the tissue element captured when a first light source illuminates the tissue region, receiving, by the visualization system controller, a second image of the tissue element within the tissue region when a second light source illuminates the tissue region, combining, by the visualization system controller, the highlighting image representation of the tissue element to the second image of the tissue element to generate a composite tissue image, and delivering, by the visualization system controller, the composite tissue image to an output device.03-22-2012
20120071764DEVICE AND METHOD FOR WIDE-FIELD AND HIGH RESOLUTION IMAGING OF TISSUE - A device for wide-field and high resolution imaging of an object surface includes first and second imaging modalities, a lens associated with the second imaging modality. The first imaging modality is high resolution with a first observation line. The second imaging modality is arranged in an image plane at a first angle with respect to an object plane and has a second observation line and a wider imaging field than the first imaging modality. The lens associated with the second imaging modality is arranged in a lens plane at a second angle with respect to the object plane, where the second angle being equal to about one-half of the first angle. The first and second imaging modalities are mutually arranged such that the first and second optical axes intersect at a point on the object plane.03-22-2012
20110077528METHOD AND APPARATUS FOR SIMULTANEOUS HEMOGLOBIN REFLECTIVITY MEASUREMENT AND OCT MEASUREMENT, THROMBUS DETECTION AND TREATMENT, AND OCT FLUSHING - A method and apparatus for simultaneous hemoglobin reflectivity measurement and OCT measurement, thrombus detection and treatment, and OCT flushing. A first optical energy for OCT and a second optical energy for hemoglobin may be used.03-31-2011
20120165683PERSONAL IDENTIFICATION SYSTEM - A personal identification system, which uses a vein pattern of a finger, optimizes the amount of light of a light source based on a captured finger image and emphasizes the vein pattern during image processing for identification.06-28-2012
20120123278LOW-NOISE OPTICAL PROBES FOR REDUCING AMBIENT NOISE - An optical probe, which is particularly suited to reduce noise in measurements taken on an easily compressible material, such as a finger, a toe, a forehead, an earlobe, or a lip, measures characteristics of the material. A neonatal and adult disposable embodiment of the probe include adhesive coated surfaces to securely affix the probe onto the patient. In addition, the surface of the probe is specially constructed to reduce the effect of ambient noise.05-17-2012
20120123277METHOD FOR DETECTING AN EXTRAORDINARY SITUATION - A method for detecting an abnormal situation of a person, a contact measuring device which the person wears directly or indirectly on the body and which is a contact sensor and/or a pressure sensor and/or a photosensor and/or a distance measuring device being used to determine a contact state and/or the pressure exerted by a body part, such as a foot of a person, onto a reference surface, such as a floor, so that an abnormal situation can be detected among a plurality of situations.05-17-2012
20090131800MULTIMODAL IMAGING SYSTEM FOR TISSUE IMAGING - An apparatus for obtaining area images and optical coherence tomography (OCT) image of a tissue comprises an image sensor, a first illumination means providing broadband polarized polychromatic light, a second illumination means providing narrow-band ultraviolet light, a third illumination means providing Near-Infrared light, an optical coherence tomography (OCT) imaging apparatus, one or more polarization elements, and an optical filter. An image processor identifies a region of interest according to area image, which can be a polarized reflectance image, a fluorescence light image, or both for the OCT imaging apparatus to obtain an OCT image over the region of interest.05-21-2009
20120123276CATHETER WITH OPTICAL CONTACT SENSING - A medical probe, including a biocompatible sheath having proximal and distal ends, and having at least one transparent strip between the proximal end and the distal end. The probe also has one or more functional elements positioned within the biocompatible sheath.05-17-2012
20080319323Tear film measurement - The invention comprises a method for measuring the relative thickness of the lipid layer component of the precorneal tear film on the surface of an eye after distribution of the lipid layer subsequent to blinking. Light is directed to the lipid layer of a patient's eye with an illuminator. The illuminator is a broad spectrum light source covering the visible region and is a lambertion light emitter such that the light source is specularly reflected from the lipid layer and undergoes constructive and destructive interference in the lipid layer. The specularly reflected light is collected and focused using a collector such that the interference patterns on the tear film lipid layer are observable. The collector also produces an output signal representative of the specularly reflected light which is suitable for further analysis, such as projection on to a high resolution video monitor or analysis by or storage in a computer. In order to facilitate ease of measurement, the patient's head may be positioned on an observation platform when the illuminator directs light to the lipid layer of the patient's eye.12-25-2008
20120130257METHOD AND APPARATUS FOR TISSUE MEASUREMENT POSITION TRACKING AND DEPTH ADJUSTMENT - The present invention pertains to a method and apparatus for pressure sore detection. A modulated optical signal based on a digital code sequence is transmitted to human tissue. A temporal transfer characteristic is derived from the modulated optical signal. Tissue characteristics is determined based on the temporal transfer characteristic.05-24-2012
20120130256Method and System for Controlling Output of RF Medical Generator - A control system for controlling the output of an electrosurgical generator is disclosed. The control system includes a control module configured to receive an optical signal from a surgical site, the optical signal being related to an optical tissue characteristic, the control module configured to process the optical signal using a closed loop control loop and provide continual control of the output of the electrosurgical generator in response to the optical tissue characteristic.05-24-2012
20120130255MEDICAL DEVICE FOR DIAGNOSING PRESSURE ULCERS - Medical device or instrument for diagnosing pressure ulcers using optical reflectance spectroscopy. The device may comprise a tip and a controller. The tip is pressed against the skin of the patient and collects the optical reflectance data. The controller processes the data to determine whether there exists a pressure ulcer and, if there is one, its depth. The tip may also include a pressure sensor for sensing the pressure at which the tip is applied to the patient's skin.05-24-2012
20120130254Dental Device for Trans-illumination of Teeth - In a dental system for the transillumination of teeth having an elongate handpiece with a light source for producing examination radiation, irradiation means for directing the examination radiation at a tooth to be examined, and means for acquiring an optical image of the tooth illuminated by the examination radiation, there is arranged at the front end of the handpiece a removable attachment which contains at least part of the irradiation means, the handpiece having means for detecting the attachment arranged on the handpiece.05-24-2012
20120130253NON-CONTACT OPTICAL SYSTEM, COMPUTER-ACCESSIBLE MEDIUM AND METHOD FOR MEASUREMENT AT LEAST ONE MECHANICAL PROPERTY OF TISSUE USING COHERENT SPECKLE TECHNIQUE(S) - Exemplary embodiments of apparatus and method for determining at least one material property of an anatomical structure can be provided. According to one exemplary embodiment, it is possible to apply at least one first coherent radiation to at least one portion of the anatomical structure, and receive at least one second coherent radiation from such portion(s). The first and second coherent radiations can be associated with one another. In addition, it is possible to determine the material property based on the second coherent radiation(s). Such determination can be performed without (i) any portion of an apparatus performing the procedure causing an induction of at least one mechanical deformation on or in the anatomical structure, and/or (ii) any mechanical deformation on or in the anatomical structure.05-24-2012
20120130252PRODUCING AN IMAGE - An optical component is connectable to a camera unit and comprises a data structure including data associated with the optical component. When the optical component is connected to the camera unit, data associated with the optical component is transferred to the camera unit. Image production of an organ by the camera unit is controlled based on the data associated with the optical component.05-24-2012
20120165682SKIN COLOR AND CAPACITIVE SENSOR SYSTEMS - A hair removal device utilizes a system for sensing the presence and color of skin. The system includes a skin color sensor assembly and a capacitive sensor assembly disposed in a housing. The skin color sensor assembly includes a light pipe communicating with a color sensor aperture of the housing and having one or more notches defining receiving and emitting light propagation regions, a color sensor and one or more light emitting diodes, and a holder having at least one standoff mated to the notches thereby directing light emitted by the light emitting diodes through the light pipe for reflection of an external surface and receipt by the sensor for detection of surface color. The capacitive sensor assembly includes a plurality of copper elements in proximity to a device aperture and contacting an interior surface of the housing and for detection of an object in contact with the copper elements.06-28-2012
20120165681Delineating Skin or Surface Lesions - A diagnostic apparatus for examining a region of skin includes a light source for emitting light toward an illumination region of the skin surface. A detector is provided for receiving light from an examination region of the skin surface. A light barrier substantially impervious to the light emitted from the light source intimately engages the skin surface to define a boundary between the illumination region and the examination region.06-28-2012
20120220878 Blanching Device for Use in Evaluating Skin Condition - A blanching device is described for use in evaluating skin condition. The blanching device has a window which is pressed against the skin, and retracts when a pre-determined pressure is reached to allow blood to re-enter the blanched region of skin. There is further described systems to evaluate skin condition using a blanching device, based on light scattered from the blanched region.08-30-2012
20100204584METHOD AND APPARATUS FOR OCULAR SURFACE IMAGING - The invention provides apparatuses and methods for detecting corneal surface defects. The methods and/or an apparatus of the invention can be used to detect corneal surface diseases, such as dry eye.08-12-2010
20120136257SNR Through Ambient Light Cancellation - Systems, methods, and devices for improved patient monitor signal processing with higher signal-to-noise ratio (SNR) are provided. In accordance with an embodiment, an electronic patient monitor may include drive circuitry, a current-to-voltage converter, and feedback circuitry. The drive circuitry may drive an emitter of a medical sensor with dark periods during which the emitter does not emit light, and the current-to-voltage converter may receive and amplify a photocurrent signal from a detector of the sensor. The feedback circuitry may provide a feedback signal to the current-to-voltage converter. The feedback signal, based at least in part on the output of the current-to-voltage converter during the dark periods, may cause the current-to-voltage converter to substantially exclude an ambient light component of the photocurrent. As a result, the current-to-voltage converter may employ a higher transimpedance without distorting the output voltage signal due to oversaturation, and thus may achieve a higher SNR.05-31-2012
20120136258Retinal Flow Cytometry - The present invention provides methods and devices for performing flow cytometry. In one embodiment, blood circulating through one or more retinal blood vessels of a subject is illuminated in-vivo so as to excite a plurality of fluorescent-labeled cells contained in the blood. The fluorescence radiation emitted by the excited cells is then detected and analyzed to count the cells from which fluorescence is detected.05-31-2012
20130184592SYSTEM AND METHOD FOR HOME HEALTH CARE MONITORING - A home health care monitoring method and system are disclosed. In one embodiment, a method includes: capturing a plurality of video sequences from a plurality of respective cameras disposed in different locations within a patient's home, including capturing two-dimensional image data and depth data for each video sequence; defining a plurality of events to monitor associated with the patient, the events including, during a predetermined time period, at least (1) the patient's body being in a particular position for at least a predetermined amount of time; performing depth-enhanced video content analysis on the plurality of video sequences to determine whether the event (1) has occurred. The video content analysis may include: for each of at least two cameras: automatically detecting a human object based on the two-dimensional image data; using the depth data to confirm whether the human object is in the particular position; and based on the confirmation, tracking an amount of time that the human object is in the particular position; and then determining that the event (1) has occurred based on the collective tracked amount of time.07-18-2013
20100022893SELF-INFLATING BLADDER - The attenuation and other optical properties of a medium are exploited to measure a thickness of the medium between a sensor and a target surface. Disclosed herein are various mediums, arrangements of hardware, and processing techniques that can be used to capture these thickness measurements and obtain three-dimensional images of the target surface in a variety of imaging contexts. This includes general techniques for imaging interior/concave surfaces as well as exterior/convex surfaces, as well as specific adaptations of these techniques to imaging ear canals, human dentition, and so forth.01-28-2010
20100049056METHOD, DEVICE, MEDICAL IMAGE ACQUISITION DEVICE FOR IMAGING AN INTERIOR OF A TURBID MEDIUM WITH DARKNESS LEVEL MEASUREMENT - The invention relates to a method, device, and medical image acquisition device for imaging an interior of a turbid medium. The method comprises the following steps: accommodation of the turbid medium inside a receiving volume (02-25-2010
20100298715METHOD AND MEASURING INSTRUMENT FOR COLLECTING SPECTROMETRIC TEST SIGNALS FROM LIVING TISSUE - The invention relates to a method and a measuring instrument for collecting spectrometric test signals from living tissue. The aim of the invention is to create solutions which make it possible to generate, in the course of a spectrometric measurement, test results that supply more comprehensive data than previously known recording attempts. Said aim is achieved by a method for generating spectrometric test signals, in which light (L) is injected into a living tissue area (G) to be examined, reflected light (R) emerging from the tissue area to be examined is fed to a spectrometer device, and test signals representing the intensity of the reflected light by associating the same with the wavelength are generated by means of the spectrometer device. The measurement is taken such that the measurement process lasts a certain period of time (T) during which data is generated that represents the time course of the intensity of the resolved wavelengths, thus advantageously making it possible to generate, during the spectrometric measurement, signals which allow specific substances, e.g. the blood components cholesterol and sugar, to be associated with specific zones of the examined tissue area.11-25-2010
20120179050ENDOSCOPE DIAGNOSIS SYSTEM - An endoscopic diagnosis system includes a white light source, a narrowband light source for emitting narrowband light having a given wavelength range of blue light, an image sensor receiving reflected light of white light and the narrowband light emitted with a given emission ratio to illuminate a subject from the subject to acquire a narrowband light image, and an image processor for calculating an enhanced luminance signal where a blue image signal of the narrowband light image is enhanced, calculating a hemoglobin index representing blood level in a medium to deep layer of a mucous membrane from a green image signal and a red image signal of the narrowband light image, calculating an enhanced color difference signal enhancing red according to a value of the hemoglobin index, and producing an image signal of an endoscopic image for display.07-12-2012
20100036260Oral cancer screening device - An oral cancer screening device 02-11-2010
20110098578OPTICAL IMAGING OF RHEUMATOID ARTHRITIS - The present invention concerns the use of indocarbocyanine dyes, in particular indotricarbocyanine dyes for the diagnosis of inflammatory diseases, in particular rheumatoid arthritis, methods of diagnosing inflammatory diseases and an apparatus useful to carry out the method of diagnosing.04-28-2011
20120253202Optoelectronic Device for The Detection of Uterine Cervical Cancer, Comprising A Self-Positioning Attachment - The disclosure is directed to a minimally-invasive diagnostic device for Papanicolaou testing and for an alternative examination method for taking a cell sample. The portable device analyzes cervical tissue using simultaneous electrical and optical measurements. The device examines different areas of cervical tissue, taking electrical measurements in different frequency ranges and optical measurements in three different wavelengths. Once obtained, the measurements are processed in accordance with mathematical formulae obtained from multiple measurements of healthy and cancerous tissues. Three possible responses can be obtained: healthy tissue, cancerous tissue, or the presence of human papilloma virus. A device attachment permits use of the device for self-detection after determining proximity to the cervix, and also includes an accessory for performing the alternative method of taking a cell sample for laboratory analysis to obtain an immediate response for use by the user or another person.10-04-2012
20120253204SYSTEMS AND METHODS FOR PHOTOTHERAPEUTIC TREATMENT OF RECTAL DISEASES - A phototherapeutic system for providing phototherapy to a patient's lower parts of a gastrointestinal (GI) tract, the phototherapeutic system including a capsule sized and shaped for insertion into the rectum, the capsule including one or more phototherapeutic light sources. A method for intra-luminal phototherapy of the lower parts of the gastrointestinal (GI) tract including inserting a phototherapeutic device including one or more phototherapeutic light sources into the rectum, activating the light sources, and providing light at a dose suitable for providing a phototherapeutic effect. Related apparatus and methods are also described.10-04-2012
20120253203METHOD OF VIEWING A SURFACE - A method of viewing a surface comprising taking at least a first image from a first position and a second image from a second position to allow for comparative analysis and diagnosis of the surface.10-04-2012
20120316446RAMAN SPECTRAL ANALYSIS FOR DISEASE DETECTION AND MONITORING - A system and method for Raman spectral analysis for diagnostic purposes to identify the disease state of biological tissue. The sampled tissue can be any human or animal tissue, including but not limited to prostate, breast, cervical tissue, etc. Raman spectroscopy is used to provide Raman bands which are decomposed and their chemical fingerprints identified after mathematical modeling. The method enables identification of chemical compounds in the tissue being diagnosed. Comparison with reference samples permits inferences concerning the presence or absence of disease, the stage of disease, and/or the response of disease to treatment. The method provides sufficient information about the chemical composition of the tissue to differentiate between normal and abnormal states, and may also reveal the locations of abnormalities. The method may also be used to monitor the treatment of a subject and/or the response of disease to drugs or other treatments.12-13-2012
20120226166DELIVERY OF BIOLOGICAL COMPOUNDS TO ISCHEMIC AND/OR INFARCTED TISSUE - The delivery of biological compounds to ischemic and/or infarcted tissue are described herein where such a system may include a deployment catheter and an attached imaging hood deployable into an expanded configuration. In use, the imaging hood is placed against or adjacent to a region of tissue to be imaged in a body lumen that is normally filled with an opaque bodily fluid such as blood. A translucent or transparent fluid, such as saline, can be pumped into the imaging hood until the fluid displaces any blood, thereby leaving a clear region of tissue to be imaged via an imaging element in the deployment catheter. Additionally, any number of therapeutic tools can also be passed through the deployment catheter and into the imaging hood for performing any number of procedures on the tissue for identifying, locating, and/or accessing ischemic and/or infarcted tissue.09-06-2012
20120259229APPARATUS AND METHODS FOR IN VIVO TISSUE CHARACTERIZATION BY RAMAN SPECTROSCOPY - A micro-Raman spectrometer system for use in differentiating tumor lesions from normal skin detects specific characteristics of Raman spectra indicative of cancer. A peak at 899 cm10-11-2012
20090054788METHOD AND APPARATUS FOR DISPLAYING A FIELD OF A BRAIN OF A PATIENT AND NAVIGATION SYSTEM FOR BRAIN SURGERY - A method and an apparatus for displaying a part of a brain of a patient is described. Laser-Doppler-images are acquired before and after a stimulation. The laser-Doppler-images include information about a blood motion or about a perfusion at the acquired part. Then, the blood motion images acquired before and after the stimulation are compared to identify areas in the brain of the patient which are related to the stimulation.02-26-2009
20090018451Dynamic Sampling System and Method for In Vivo Fluorescent Molecular Imaging - A dynamic dada sampling system and method is disclosed for in vivo small animal fluorescence molecular imaging and dual-modality molecular imaging. The system comprises a computer, a rotation stage for animal suspension driven by a motor, and a fluorescence excitation-detection apparatus. The fluorescence excitation-detection apparatus comprises a fluorescence excitation module and a fluorescence detection module. The CCD device of the fluorescence detection module is connected to a computer through an interface controller. The motor is connected to a computer through RS232 interface. The process of dynamic data acquisition is as follows: a fluorescent probe is injected into a small animal in order to target specific cells or tissues; a small animal is vertically hung on a rotation stage after anesthesia; the fluorescence imaging detection module acquires the emitting light continuously. The present invention can provide 360 degree imaging quickly, efficiently, and non-invasively.01-15-2009
20110125029Targeted Dual-Axes Confocal Imaging Apparatus with Vertical Scanning Capabilities - An optical device is described that may be used as a microscope system for real-time, three-dimensional optical imaging. The device includes a miniature, fiber optic, intra-vital probe microscope that uses a dual-axes confocal architecture to allow for vertical scanning perpendicular to a surface of the sample (e.g., a tissue surface). The optical device can use off-axis illumination and collection of light to achieve sub-cellular resolution with deep tissue penetration. The optical device may be used as part of an integrated molecular imaging strategy using fluorescence-labeled peptides to detect cell surface targets that are up-regulated by the epithelium and/or endothelium of colon and breast tumors in small animal models of cancer.05-26-2011
20120232406Oral screening device - An oral cancer screening device 09-13-2012
20120232405COMPACT PROBE FOR TRACER-ASSISTED DIAGNOSTIC AND SURGERY - A simple and potentially disposable compact probe of FIG. 09-13-2012
20120232404Method And Apparatus For Rapid Detection And Diagnosis Of Tissue Abnormalities - A method and apparatus are provided that interrogate, receive, and analyze full emission spectra for at least one fluorescence excitation wavelength and for at least one reflectance measurement to determine tissue characteristics and correlate same to photographic images. Further, the system and method accomplish this measurement rapidly by increasing the light throughput by integrating optics into a hand held unit and avoiding the need for a coherent fiber optic bundle being used. The method includes illuminating a first portion of a target tissue with optical energy, forming a first image of the target tissue, illuminating a second portion of the target tissue with optical energy, performing spectroscopic measurements on optical energy reflected and/or emitted by the target tissue upon illumination of the second portion of the target tissue with optical energy, and determining tissue characteristics of the target tissue based on the results of the spectroscopic measurements.09-13-2012
20110004106OPTICAL BIOLOGICAL INFORMATION DETECTING APPARATUS AND OPTICAL BIOLOGICAL INFORMATION DETECTING METHOD - An optical biological information detecting apparatus includes a light emitting unit which emits observation light of a specific wavelength band to optically observe a desired portion of a tissue of a skin of a human body, and an annular light guide unit which guides the observation light to a desired area of a surface of the skin corresponding to the desired portion of the tissue of the skin, and which annularly irradiates the observation light onto the desired area of the surface of the skin. The apparatus further includes a light receiving unit which is disposed at a position surrounded by the annular light guide unit, and which receives scattered light scattered by the desired portion of the tissue of the skin after the observation light is annularly irradiated onto the desired area of the surface of the skin by the annular light guide unit.01-06-2011
20120130258PROGRAMMABLE MULTIPSPECTRAL ILLIUMINATION SYSTEM FOR SURGERY AND VISUALIZATION OF LIGHT-SENSITIVE TISSUES - An observation system for viewing light-sensitive tissue includes an illumination system configured to illuminate the light-sensitive tissue, an imaging system configured to image at least a portion of the light-sensitive tissue upon being illuminated by the illumination system, and an image display system in communication with the imaging system to display an image of the portion of the light-sensitive tissue. The illumination system is configured to illuminate the light-sensitive tissue with a reduced amount of light within a preselected wavelength range compared to multispectral illumination light, and the image of the portion of the light-sensitive tissue is compensated for the reduced amount of light within the preselected frequency range to approximate an image of the light-sensitive tissue under the multispectral illumination05-24-2012
20120330161CO2 SENSOR AND CO2 MEASURING APPARATUS12-27-2012
20100234739SPECTROSCOPIC OBSERVATION DEVICE, ENDOSCOPE SYSTEM, AND CAPSULE ENDOSCOPE SYSTEM - A spectroscopic observation device enables proper observation by respectively meeting the observation condition where easy-to-observe image with high S/N ratio is preferable and the observation condition where it is preferable to restrain interfusion of any other fluorescent components, even when fluorescence of the same wavelength is to be observed. The spectroscopic observation device comprises: an excitation light source (09-16-2010
20100234738DIAGNOSTIC SYSTEMS AND METHODS UTILIZING PROBE-IONS EXHIBITING PHOTON AVALANCHE EFFECT - The present disclosure provides advantageous systems and methods for significantly increasing the sensitivity and selectivity for diagnostic procedures, e.g., optical biopsy. The disclosed systems and methods use a highly non-linear effect, the so-called photon avalanche. In the regime close to the avalanche threshold, small differences in density of the probe-ion under investigation or the excitation power can result in very large changes in up-conversion emission intensity. Through this effect, it becomes possible to accurately measure the signal of an optical biopsy probe-ion only in the location(s) where its concentration is highest, while at the same time significantly reducing or eliminating measurement of background signal from probe-ions distributed with a somewhat lower concentration throughout the measurement volume. Also background auto-fluorescence of the surrounding healthy tissue is essentially absent with this technique.09-16-2010
20120277594MENTAL HEALTH AND WELL-BEING - Mental illness is a huge burden on those afflicted with it, as well as their caregivers and represents a major cost to society as a whole. The invention herein is concerned with methods and apparatus to improve the well-being of persons afflicted with mental illness, as well as to provide early and better diagnosis. It is felt that in some cases such diagnosis can lead to a potential for eliminating the worst effects of the illness altogether, by allowing intervention before a first psychotic episode occurs. The invention uses sensors, primarily 2D or 3D cameras and voice recognition to observe persons in many instances during ordinary activity such as playing video games, chatting on the internet or other such computer based activity.11-01-2012
20110245686OPTICALLY CHARACTERIZING TURBID MEDIA AND SUBSTANCES IN TURBID MEDIA - For optically interrogating substances overlaid by turbid media a method of wavefront manipulation by means of binary phase masking is disclosed. Through altering the degree of mode conformity between the fields reaching the collection optics and the field distributions of the propagation modes of optical waveguides the disclosed method can be used to suppress the collection of short-range light originated near the collection optics while permitting unimpeded collection of light originated from sites substantially behind turbid media.10-06-2011
20120089031SYSTEMS AND METHODS FOR SIDESSTREAM DARK FIELD IMAGING - The present application discloses systems and methods for the comprehensive monitoring of the microcirculation in order to assess the ultimate efficacy of the cardiovascular system in delivering adequate amounts of oxygen to the organ cells. In some cases, system embodiments may utilize reflectance avoidance by reflectance filtering, such as OPS imaging or Mainstream Dark Field imaging, or by Sidestream Dark Field imaging, which utilizes external direct light on the tip of the light guide to achieve reflectance avoidance whereby incident and reflected light do not travel down the same pathway.04-12-2012
20120330163MEASURING APPARATUS - The present invention provides a measuring apparatus including: a supporting member which supports a subject person and has an opening for inserting an object that is a part of the subject person; and a first holding member and a second holding member for interposing and compressing the object when the object is inserted through the opening, wherein at least two of the supporting member, the first holding member and the second holding member can move independently from one another in a direction of compressing the object.12-27-2012
20120330164NONINVASIVE MEASUREMENT OF CAROTENOIDS IN BIOLOGICAL TISSUE - A method and apparatus are provided for the determination of carotenoid antioxidants and similar chemical compounds in biological tissue such as living skin. The method and apparatus provide a noninvasive, rapid, accurate, and safe determination of carotenoid levels which in turn can provide diagnostic information of the antioxidant status of tissue. Reflection spectroscopy is used to measure the concentrations of carotenoids and similar substances in tissue. White light is directed upon the area of tissue that is of interest. A small fraction of diffusively scattered light is collected and measured. The tissue is pressured to temporarily squeeze blood out of the measured tissue volume while the reflection spectrum is continuously monitored, displayed, and analyzed in near real time. After an optimal time period of typically 15 seconds, the influence of the dominating hemoglobin and oxyhemoglobin tissue absorptions on the reflection spectra are minimized.12-27-2012
20120330165FLUOROSCOPY APPARATUS - A fluoroscopy apparatus is adopted which includes a fluorescence-image generating section that generates a fluorescence image of a subject, a white-light-image generating section that generates a white-light image of the subject, a fluorescence-image correcting section that generates a corrected fluorescence image in which luminance values of pixels are normalized by dividing the luminance values of the pixels of the fluorescence image by the luminance values of the pixels of the white-light image, an error-image identifying section that standardizes white-light-image acquisition conditions and identifies an error region, which is a region in which the luminance values of the corrected fluorescence image exceed a preset allowable error range, on the basis of a gray level of the normalized white-light image, and a monitor that displays the error region.12-27-2012
20120330162MODULATED APERTURE IMAGING FOR AUTOMATIC MOVING TARGET DETECTION - Traditional methods of detecting a moving target involve acquisition of video rate imagery in which data is acquired, stored, transmitted and then processed. Processing requires software for high precision frame-to-frame registration, detection and tracking. Example embodiments of the present invention include a method and an apparatus for generating instantaneous velocity maps that do not require acquisition, transmission, storing or processing of video-rate data. Incident radiation is directed onto one or more detectors, the detectors operating at a frame rate. The detectors acquire the first and second complementary sub-images of a single frame. The first and second complementary sub-images are combined to yield the change detection map. Example embodiments of the methods and devices described herein can be used in automatic detection of motion without tracking, optimization of image deblurring and optimization of detection of high speed and high frequency events, among others.12-27-2012
20120101391BLOOD VESSEL WALL ANALYZING DEVICE AND BLOOD VESSEL WALL ANALYZING METHOD - The present invention relates to a blood vessel wall analyzing apparatus provided with a structure enabling accurate measurement of plaque components in a blood vessel wall in a state that reduces the burden on a patient. In the blood vessel wall analyzing apparatus (04-26-2012
20120101390Multi-Modal Imaging for Diagnosis of Early Stage Epithelial Cancers - Epithelial cancer screening can include a staining tissue with a cancer targeting agent, identifying a potentially cancerous lesion using fluorescence imaging, and imaging the potentially cancerous lesion for a cancer diagnosis using optical coherence tomography.04-26-2012
20130012822APPARATUS FOR MEASURING THE LUMINANCE AND TEMPERATURE OF A LIGHT SOURCE OF A SPECTROPHOTOMETRIC DEVICE - A system for measuring the luminance and temperature of a light source element of a spectrophotometric device is provided. The system includes a photodiode, a luminance measuring device, a temperature measuring device, a first switch, and a controller. The photodiode is operable to receive light signals emitted by the light source element and passing through a subject's body tissue. The luminance measuring device is operable to measure luminance of the light signals received by the photodiode. The temperature measuring device is operable to measure the temperature of the photodiode. The first switch is operable to connect the photodiode to the luminance measuring device or the temperature measuring device. The controller is operable to control the connection of the first switch.01-10-2013
20100130870METHOD FOR REAL TIME TUMOUR VISUALISATION AND DEMARCATION BY MEANS OF PHOTODYNAMIC DIAGNOSIS - Proposed invention is related to the field of photodynamic therapy and photodiagnosis. Specifically, a new algorithm is presented for visualisation and spatial demarcation of various types of tumours and unhealthy tissue through unsupervised segmentation of the fluorescent multispectral image. Image is acquired through recording of the emission of the tissue illuminated by the light that induces fluorescence in the tumour. For this purpose tissue is treated by photo sensitizer. Algorithm for real time visualisation and spatial demarcation of the tumour by means of the analysis of fluorescent image consists of the recording of the fluorescent image (05-27-2010
20100130869METHOD AND APPARATUS FOR DISPLAYING A FIELD OF A BRAIN OF A PATIENT AND NAVIGATION SYSTEM FOR BRAIN SURGERY - A method and an apparatus for displaying a part of a brain of a patient is provided. Laser Doppler images are acquired before and after a stimulation. The laser Doppler images comprise information about a blood motion or about a perfusion at the acquired part. Then, the blood motion images acquired before and after the stimulation are compared to identify areas in the brain of the patient which are related to the stimulation. The identified areas are displayed in dependence of topography data representing a topography of the brain.05-27-2010
20120150044PHOTOTHERAPY DEVICE AND METHOD - Disclosed is a phototherapy device including: a pixel unit to irradiate light having a predetermined wavelength to a skin, detect a skin reflection light of the light irradiated to the skin, and convert the detected skin reflection light into an electrical signal; an image processor to use the electrical signals to generate skin image information; and a control unit to control light intensity irradiated to the skin for a skin diagnosis or a skin disease therapy based on the skin image information, or to determine a two-dimensional distribution of the light. The phototherapy device of the present disclosure simultaneously provides the diagnosis and therapy of the skin disease.06-14-2012
20120150042VACUUM-PUMP SUCKER - This invention relates to a vacuum-pump sucker for high-resolution microscopy comprising a sucker body and a transparent plate. The vacuum-pump sucker is designed as a stabilizer for sample stabilization in a clinical optical virtual biopsy system with sub-micron resolution. The sucker is connected with a vacuum pump. As the vacuum pump pumps out air or gas, tissues around the imaged area will be sucked by the sucker and the distance between objective lens and the imaged tissue can be stabilized. In this way, the stability and resolution of the clinical biopsy system can be greatly improved.06-14-2012
20130018271METHODOLOGY AND APPARATUS FOR OBJECTIVE ASSESSMENT AND RATING OF PSORIASIS LESION THICKNESS USING DIGITAL IMAGINGAANM Mohamad Hani; Ahmad FadzilAACI TronohAACO MYAAGP Mohamad Hani; Ahmad Fadzil Tronoh MYAANM Fitriyah; HurriyatulAACI TronohAACO MYAAGP Fitriyah; Hurriyatul Tronoh MY - The present invention relates generally to a method and apparatus for assessing data from digital images of psoriasis lesion for said psoriasis lesion thickness by utilizing a developed computer vision system to obtain Psoriasis Area and Severity Index (PASI) parameters in particular.01-17-2013
20130018270OPTICAL OBSERVATION SYSTEM AND METHOD OF OBSERVING EXAMINATION SUBJECTAANM MIZUNAKA; MasaruAACI TokyoAACO JPAAGP MIZUNAKA; Masaru Tokyo JPAANM MURAYAMA; MasanoriAACI Wako-shiAACO JPAAGP MURAYAMA; Masanori Wako-shi JPAANM MIYAWAKI; AtsushiAACI Wako-shiAACO JPAAGP MIYAWAKI; Atsushi Wako-shi JP - Provided is an optical observation system that is provided with a portable device, which is secured to an examination subject A and is moved together with the movement of the examination subject, and an external device disposed away from the examination subject, wherein the portable device is provided with a light source; an illumination optical system radiates light coming from the light source onto an observation target site in the examination subject; a detection optical system optically guides light coming from the observation target site; a photodetector detects the light optically guided thereto by the detection optical system and converts the light to an electrical signal; and a transmitter wirelessly transmits the electrical signal output from the photodetector; and the external device is provided with a receiver receives the electrical signal transmitted from the portable device and a signal processor processes the electrical signal received by the receiver.01-17-2013
20100168585PERSONAL AUTHENTICATION METHOD AND PERSONAL AUTHENTICATION DEVICE UTILIZING FINGER-TIP BLOOD FLOW MEASUREMENT BY LASER LIGHT - A personal authentication method is provided that includes imaging, on an image sensor as a laser speckle using an optical system, light reflected from a blood vessel layer in subcutaneous and internal tissues when a laser beam is expanded and made to irradiate a finger pad, calculating a quantity that represents the rate of change with respect to time of the amount of light received for each pixel of the laser speckle, obtaining a finger pad blood flow map as a two-dimensional map of the numerical values, and comparison-checking the blood flow map against pre-registered data of individuals, wherein using a near-infrared laser beam or using this in combination with a visible laser beam, comparison-checking against pre-registered data of individuals is carried out using a pattern reflecting a fingerprint occurring within the finger pad blood flow map obtained from reflected light and, observed superimposed thereon, an internal tissue blood flow distribution pattern, and there is also provided a device used for the method.07-01-2010
20100168586Optical imaging or spectroscopy systems and methods - Optical imaging or spectroscopy described can use laminar optical tomography (LOT), diffuse correlation spectroscopy (DCS), or the like. An incident beam is scanned across a target. An orthogonal or oblique optical response can be obtained, such as concurrently at different distances from the incident beam. The optical response from multiple incident wavelengths can be concurrently obtained by dispersing the response wavelengths in a direction orthogonal to the response distances from the incident beam. Temporal correlation can be measured, from which flow and other parameters can be computed. An optical conduit can enable endoscopic or laparoscopic imaging or spectroscopy of internal target locations. An articulating arm can communicate the light for performing the LOT, DCS, or the like. The imaging can find use for skin cancer diagnosis, such as distinguishing lentigo maligna (LM) from lentigo maligna melanoma (LMM).07-01-2010
20130023774MINIATURE SPECTROMETER - A miniaturized spectrometer is adapted for placement within a body near tissue to be characterized. The spectrometer includes a light source and a plurality of light detectors. The light source generates light to illuminate the tissue. The detectors detect optical signals from the illuminated tissue and convert these optical signals to electrical signals. The miniaturized spectrometer can be disposed at the distal end of an interventional device. Optical conduits, such as fiber optic cables or strands, extending the length of the interventional device are not required when the miniature spectrometer is employed.01-24-2013
20130172759Systems And Methods For Using Photoplethysmography In The Administration Of Narcotic Reversal Agents - Provided according to embodiments of the present invention are methods of monitoring and treating respiratory depression that include securing a photoplethysmography (PPG) sensor to a central source site of an individual; administering a central nervous system (CNS) depressant to the individual; processing PPG signals front the PPG sensor with a computer in communication with the PPG sensor; and administering a narcotic reversal agent to the individual if the PPG signals or a physiological parameter derived therefrom are outside a preset value range. Related systems are also described.07-04-2013
20080255458SYSTEM AND METHOD USING FLUORESCENCE TO EXAMINE WITHIN A PATIENT'S ANATOMY - A system for examining an area of a patient's anatomy that comprises a probe capable of fluorescing, and a scanning beam assembly that scans the probe with a beam of excitation radiation and detects the probe's fluorescence. The scanning beam assembly including a radiation source capable of emitting one or more wavelengths of radiation that are capable of exciting the probe and causing the probe to fluoresce, a scanning device that directs the radiation onto a field-of-view to create a scan of the field-of-view, a detector to detect radiation returned from the field-of-view, and a controller to convert the detected radiation into a displayable fluorescence image.10-16-2008
20130178748METHOD FOR IDENTIFYING MALIGNANCIES IN BARRETT'S ESOPHAGUS USING WHITE LIGHT ENDOSCOPY - A method is described for computing a statistically significant difference between dysplasia and Barrett's esophagus (both with and without inflammatory component) using a discriminate function with diffuse reflectance measurements performed at a minimum of four different wavelengths of 485, 513, 598, and 629 nm. The discriminate function found depends both on local blood fraction volume T07-11-2013
20080221456Optical Sensor and a Method of Its Use - The invention provides a device 09-11-2008
20100042004Method and Apparatus for Multi-spectral Imaging and Analysis of Skin Lesions and Biological Tissues - A multispectral nevoscope that uses specific wavelengths in the visible and infrared spectrum of electromagnetic radiation to transilluminate a skin-lesion or a biological tissue or specimen for imaging and maps multispectral 2-dimensional images into 3-dimensional virtual space for providing 3-D distributions of pre-defined parameters representing the characteristic properties (such as melanin, hemoglobin and deoxyhemoglobin, etc.) of a skin lesion. Methods are disclosed for analyzing and using the characteristic distributions of specific parameters for detection and management of skin-cancers, or characterization of a biological tissue or specimen.02-18-2010
20130137993OPTICAL CAPSULE AND SPECTROSCOPIC METHOD FOR TREATING AND DIAGNOSING THE INTESTINAL TRACT - A device and method for mapping, diagnosing and treating disorders or other diseases, disorders or conditions (e.g., bleeding, ischemic or necrotic tissue, and presence of certain chemicals or substances) of the intestinal tract is provided using a capsule passing through the intestinal tract and sensing optical characteristics as the capsule passes through. Further, a capsule tracking system is provided for tracking a capsule's location along the length of an intestinal tract as various treatment and/or sensing modalities are employed. In one variation, an acoustic signal is used to determine the location of the capsule. A map of optical characteristics may be derived from the pass of a capsule to diagnose the disorder or disease. The capsule or subsequently passed capsules may treat, further diagnose or mark the intestinal tract at a determined location along its length.05-30-2013
20130102907BIOLOGICAL PHOTOMETRIC DEVICE AND BIOLOGICAL PHOTOMETRY METHOD USING SAME - The present invention is capable of separating/removing the influence of skin blood flow contained in near infrared spectroscopy (NIRS) signals and extracting a brain- or brain cortex-origin signal. Moreover, the present invention enables versatile separation of brain-origin and skin-origin signals in view of differences among individuals. A biological photometric device, wherein light transmitters and light receivers are located in such a manner that measurement can be conducted at a plurality of source-detector (SD) distances and light received by the individual light-receivers can pass through the gray matter to thereby separate a brain-origin signal and a skin-origin signal. Individual component analysis (ICA) is conducted on data obtained at the individual measurement points. Then, it is determined whether each individual component originates in the brain or in the skin with the use of the SD distance-dependency of the weighted value of each of the separated components.04-25-2013
20130102906ILLUMINATOR FOR PHOTODYNAMIC THERAPY - An apparatus and method for photodynamic therapy or photodynamic diagnosis using an illuminator comprising a plurality of light sources generally conforming to a contoured surface and irradiating the contoured surface with substantially uniform intensity visible light. The light sources may comprise generally U-shaped fluorescent tubes that are driven by electronic ballasts. The spacing of the U-shaped tubes is varied to increase the output at the edges of the illuminator to make the output more uniform. Also, different portions of the tubes are cooled at different amounts, to improve uniformity. A light sensor monitors output from the U-shaped tubes to provide a signal for adjusting the output from the tubes.04-25-2013
20130123645Kinematic System - A kinematic system is described. The kinematic system includes a kinematic device for attachment to a subject's body part. The kinematic device projects a light line, and a movement of the light line is used to evaluate a movement, posture, or balance of the subject.05-16-2013
20080200818Surface measurement apparatus and method using parallax views - The invention provides for surface mapping of in-vivo imaging subjects using a single camera having a lens which is not telecentric in object space, and a moveable stage on which a subject animal for in-vivo imaging is placed. Images are taken and the stage is moved by known amounts, and the height of individual features on the subject is determined through analysis of how much the feature shifts in the image, given the known stage displacement and lens placement. A mesh or other surface can be constructed from individual features, to provide a map of the subject. Alternatively, two cameras are used in a calibrated stereo viewing arrangement. Resolution of 0.5 mm or better can be attained for mice and similarly sized subjects.08-21-2008
20080200817Electronic Polarimetric Imaging System for a Colposcopy Device and an Adapter Housing - The invention relates to an electronic polarimetric imaging system use in a colposcopy device for in vivo monitoring a cervix, which is provided with a light source for illuminating the observable cervix and at least visual means for monitoring said cervix, wherein the illumination optical path directed to the cervix and the image optical path coming back from the cervix are separated from each other on at least a portion of the paths thereof. The inventive system comprises a polarimetric adapter housing which is removable in the separated portion of the illumination and image optical paths and comprises a polarization state generator (PSG) positioned on the illumination optical path and a polarization analyser (PSA) positioned on the image optical path, wherein said polarization state generator (PSG) and polarization analyser (PSA) are designed in such a way that they are controllable. Said invention makes it possible to obtain several polarimetric characterisation levels. The adapter housing is also disclosed.08-21-2008
20110213252AUTOFLUORESCENCE IMAGING SYSTEM FOR ENDOSCOPY - A system and method for imaging tissue autofluorescence through a video endoscope is described, comprising a light source capable of providing both ultraviolet light capable of inducing tissue autofluorescence and visible light which induces little or no autofluorescence, an optical system to deliver both wavelength bands to the tissue with the same apparent spatial and angular intensity distribution, a means for digitally acquiring the resulting, visible fluorescence and visible reflectance images using a single imaging detector at the distal tip of the endoscope and a means for digitally processing said images to generate a final, false-color image for display which indicates regions of tissue dysplasia. This system can either be added on to an existing video endoscope or integrated into its structure. The combined system can be electronically switched between normal white light imaging and fluorescence imaging.09-01-2011
20100286529NEAR INFRA RED FLUORESCENCE IMAGING FOR VISUALIZATION OF BLOOD VESSELS DURING ENDOSCOPIC HARVEST - Endoscopic identification and dissection of a blood vessel in tissue during endoscopic harvest can be enhanced by injecting a bolus of ICG into the bloodstream, illuminating the target vessels with excitation light capable of exciting fluorescence in the ICG, and locating the vessel to be harvested by observing the ICG fluorescence. Moreover, collapsed blood vessel may be harvested by inserting an endoscope into the collapsed blood vessel, injecting into the collapsed blood vessel a bolus containing ICG to re-inflate the blood vessel, illuminating the target vessels with excitation light capable of exciting fluorescence in the ICG; and locating the re-inflated blood vessel by observing the ICG fluorescence.11-11-2010
20110245685BLOOD VESSEL DISPLAY DEVICE - A blood vessel display device includes: a detection unit that scans body tissue with laser light for detection and detects reflected light from an irradiated part of the body tissue to which the laser light for detection has been irradiated; an image data generating unit that detects a surface shape of the irradiated part and the arrangement of blood vessels, which are present in a superficial layer of the irradiated part, on the basis of a detection result of the detection unit and generates image data of an image for visualizing the blood vessels displayed on the irradiated part; and a display unit that displays an image for visualizing the blood vessels on the irradiated part by scanning the irradiated part with laser light for display on the basis of the image data generated by the image data generating unit.10-06-2011
20110237958OPTICAL COHERENT CROSS-SECTIONAL IMAGE FORMING APPARATUS AND CONTROL METHOD FOR CONTROLLING SUCH APPARATUS - An optical coherent cross-sectional image forming apparatus in which light outputted from a light source is divided into a measurement light and a reference light inside the apparatus and in which a cross-sectional image is formed based on a coherent light, produced from a reflected light obtained by emitting the measurement light to a biological tissue through a probe inserted into a body lumen, and the reference light, wherein the apparatus includes a detector for detecting that a transmitting and receiving unit entered inside a guiding catheter for guiding the probe by using data during the axial-direction movement and a controller for stopping at least a portion of a process associated with from generation to holding of the cross-sectional image based on the optical coherence in a case in which it is detected by the detector that the transmitting and receiving unit entered inside the guiding catheter.09-29-2011
20120277593IMAGING BASED INTERFEROMETRIC PRESSURE SENSOR - An imaging based interferometric pressure sensor apparatus compromise a fluid pressure sensor unit (11-01-2012
20130150728MEDICAL APPARATUS - A medical apparatus has a light source section capable of irradiating an excitation light and a reference light alternately, an image pickup section that picks up images of fluorescence by the excitation light, and reflected light of the reference light, a pixel addition processing section that performs pixel addition processing of making a plurality of pixels in a first image as a fluorescence image one pixel, and generates a second image, an adjusting section that makes adjustment so that a brightness ratio of the second image and a reference light image obtained by picking up of the image of the reflected light has a constant value, and thereby generates a third image signal and a fourth image, an interpolation processing section that applies interpolation processing to the third image, and generates a fifth image, and an image processing section that performs image synthesis of the fifth image and the fourth image.06-13-2013
20130150729Sanitary cover sleeve for medical device with electrical contact - A disposable cover sleeve serves is used to cover an electronic or optical medical device used for patient examination and/or treatment. The cover sleeve provides an environmental barrier for the medical device during patient examination to prevent environmental cross-contamination of different patients examined with the same medical device. The cover sleeve has an integrated device activation means such as a flexible contact bridge. The device activation means has an open and closed position. The open position is not in physical, electronic or magnetic contact with the control electronics of the medical device; whereas, the closed position closes a field or circuit between a first and second contact to selectively actuate or provide input to the control electronics that communicate with the radiation source.06-13-2013
20130150730COOLING SYSTEM FOR A PHOTOCOSMETIC DEVICE - Photocosmetic device for use in medical or non-medical environments (e.g., a home, barbershop, or spa), which can be used for a variety of tissue treatments. Radiation is delivered to the tissue via optical systems designed to pattern the radiation and project the radiation to a particular depth. The device has a variety of cooling systems including phase change cooling solids and liquids to cool treated skin and the radiation sources. Contact sensors and motion sensor may be used to enhance treatment. The device may be modular to facilitate manufacture and replacement of parts.06-13-2013
20130131519LIGHT-GUIDING DEVICES AND MONITORING DEVICES INCORPORATING SAME - A monitoring device configured to be attached to the ear of a person includes a base, an earbud housing extending outwardly from the base that is configured to be positioned within an ear of a subject, and a cover surrounding the earbud housing. The base includes a speaker, an optical emitter, and an optical detector. The cover includes light transmissive material that is in optical communication with the optical emitter and the optical detector and serves as a light guide to deliver light from the optical emitter into the ear canal of the subject wearing the device at one or more predetermined locations and to collect light external to the earbud housing and deliver the collected light to the optical detector.05-23-2013
20120259228TRI MODAL SPECTROSCOPIC IMAGING - The present invention relates to a spectroscopic imaging system using autofluorescence and reflectance images to diagnose tissue. A preferred embodiment of the invention uses a plurality of light sources to illuminate a tissue region to provide the fluorescence and reflectance images, respectively.10-11-2012
20100317975METHOD AND SYSTEM OF SPECTRALLY ENCODED IMAGING - A spectrally encoded imaging device having a light transmission path arrangement which propagates light to illuminate a target object, a light collection path arrangement having a light collection waveguide which propagates a spectrally encoded portion of the light from the target object to a detector which forms an image of the target object accordingly, and a diffractive element which spectrally disperses at least one of the light and the spectrally encoded portion. The light transmission path arrangement and the light collection path arrangement are optically isolated from one another.12-16-2010
20100317974DETECTION OF VULNERABLE PLAQUES BY RAMAN SPECTROSCOPY - An apparatus and method of use for detecting vulnerable plaque (VP) in arterial walls is provided. The method includes measuring whether the Raman spectrum of adipose (lipid) tissue signal is present in a Raman signal from aortic intimal wall tissue. The Raman vibration modes for VP are strong bands at about 1435 cm12-16-2010
20120283575REMOTE NON-INVASIVE PARAMETER SENSING SYSTEM AND METHOD - A remote parameter sensing system is provide that includes a gel sensor, a light source, a detector and a controller 11-08-2012
20120283574Diagnosis Support System Providing Guidance to a User by Automated Retrieval of Similar Cancer Images with User Feedback - The present invention is a diagnosis support system providing automated guidance to a user by automated retrieval of similar disease images and user feedback. High resolution standardized labeled and unlabeled, annotated and non-annotated images of diseased tissue in a database are clustered, preferably with expert feedback. An image retrieval application automatically computes image signatures for a query image and a representative image from each cluster, by segmenting the images into regions and extracting image features in the regions to produce feature vectors, and then comparing the feature vectors using a similarity measure. Preferably the features of the image signatures are extended beyond shape, color and texture of regions, by features specific to the disease. Optionally, the most discriminative features are used in creating the image signatures. A list of the most similar images is returned in response to a query. Keyword query is also supported.11-08-2012
20120283573DETECTION DEVICE FOR CHINESE MEDICAL INSPECTION DIAGNOSIS - The present invention is to provide a monitoring device for inspection diagnosis in traditional Chinese medicine, comprising: a housing, a light source and a shooting structure, the said light source and shooting structure are positioned in the housing, a photoconductive component is positioned in the said housing, the said photoconductive component comprising at least one photoconductive layer, the said light source is positioned inside the photoconductive layer or on the side cross section of the photoconductive layer, with the diffuse reflection of the photoconductive component the said light source forms a area light source. In the present invention, as the photoconductive component is adopted in light transmission, the point light is converted to area light so that a soft, stable and uniform illumination environment similar to the natural light comes into being in the monitoring device.11-08-2012
20130158413OPTICAL MEASUREMENT OF PHYSIOLOGICAL BLOOD PARAMETERS - Systems and methods for measuring a physiological parameter of tissue in a patient are provided herein, such as a system to optically analyze tissue of a patient. An example system includes a tissue interface assembly configured to emit an input optical signal into the tissue, receive a reference optical signal and a measurement optical signal from the tissue, and transfer the reference optical signal and the measurement optical signal to the optical link. The optical link is configured to transfer the reference optical signal and the measurement optical signal. The transceiver is configured to receive and convert the optical signals into digital signals.06-20-2013
20130158412TISSUE INTERFACE SYSTEMS FOR OPTICAL MEASUREMENT OF PHYSIOLOGICAL BLOOD PARAMETERS - Systems and methods for measuring a physiological parameter of tissue in a patient are provided herein. In a first example, tissue interface pad for applying optical signals to tissue of a patient is provided. The tissue interface pad includes a first surface configured to interface with the tissue of the patient and further includes a first guide channel disposed generally parallel to a second guide channel. The first guide channel is configured to route an input optical fiber to a first location and optically couple an end of the input optical fiber to the tissue at the first location. The second guide channel is configured to route an output optical fiber to a second location and optically couple an end of the output optical fiber to the tissue at the second location.06-20-2013
20130123642ESTIMATING APPARATUS AND ESTIMATING METHOD - A photodynamic therapy apparatus as an estimating apparatus is an apparatus for irradiating a tissue having absorbed photo-sensitive pharmaceutical, the photo-sensitive pharmaceutical absorbing an excitation light and emitting fluorescence, with the excitation light emitted from a tip portion of a laser the catheter, including a connector, a light source, and a light detection unit. The laser the catheter is capable of being attached/detached to/from the connector. The light source outputs the excitation light to the laser the catheter via the connector. The light detection unit detects intensity or a spectrum of the fluorescence, the fluorescence being entered from the laser the catheter via the connector, to estimate whether the tissue has changed because of reaction between the excitation light emitted from the tip portion of the laser the catheter and the photo-sensitive pharmaceutical absorbed in the tissue.05-16-2013
20110313295Fluorescence Method and System - A method for detecting changes in a human or animal eye is provided. The method includes illuminating the eye or at least a part thereof, in particular the lens and/or cornea, using light at a red edge excitation wavelength; detecting fluorescence caused by the red edge excitation and using the detected fluorescence to detect or identify structural defects or changes in the eye.12-22-2011
20130190628WIRE-TYPE WAVEGUIDE FOR TERAHERTZ RADIATION - In order to guide electromagnetic waves in the terahertz range over long distances of several meters with low bending losses and large bandwidth, a device, a system and a method are provided such that electromagnetic waves in the terahertz range can be coupled into a wire having a core structure and at least one confinement structure, wherein the confinement structure extends continuously along a length of the wire.07-25-2013
20130197371DIAGNOSTIC SYSTEM - A diagnostic system comprises a spectral image shooting means that shoots a spectral image within a predetermined wavelength range in a body cavity and obtains spectral image data, an image processing means that obtains the spectral image data and calculates an indicator indicating an area having a high possibility of a diseased portion from the spectral image data, and a monitor on which the indicator is displayed, and wherein the image processing means calculates, as the indicator, a ratio between an accumulated value of intensity values of all spectral images in the predetermined wavelength range and an intensity value of spectral images in a particular wavelength band, for each coordinate in the spectral image.08-01-2013
20130197372DETECTION DEVICE, DETECTING METHOD, CONTROL PROGRAM AND RECORDING MEDIUM - A detection device (08-01-2013
20130197370Automated Pneumothorax Detection - A method of determining the presence of a pneumothorax includes obtaining a series of frames of image data relating to a region of interest including a pleural interface of a lung. The image data includes at least a first frame and a second frame. The method further includes identifying, via processing circuitry, the pleural interface in at least the first frame and the second frame, determining, based on computing optical flow between the first and second frames, a pleural sliding classification of the image data at the pleural interface, and determining whether a pneumothorax is present in the pleural interface based on the pleural sliding classification.08-01-2013
20120046554Fluorescent Fiberoptic Probe for Tissue Health Discrimination and Method of Use Thereof - A system and method for the in situ discrimination of healthy and diseased tissue. A fiberoptic based probe is employed to direct ultraviolet illumination onto a tissue specimen and to collect the fluorescent response radiation. The response radiation is observed at three selected wavelengths, one of which corresponds to an isosbestic point. In one example, the isosbestic point occurs at about 431 nm. The intensities of the observed signals are normalized using the 431 nm intensity. A score is determined using the ratios in a discriminant analysis. The tissue under examination is resected or not, based on the diagnosis of disease or health, according to the outcome of the discriminant analysis.02-23-2012
20130204141PHYSIOLOGICAL SENSOR - A sensor used to measure physiological characteristics of body tissues is provided. The physiological sensor includes a first light source assembly having a first light source in parallel with a second light source. Each of the first light source and the second light source have an anode and a cathode. A second light source assembly includes a third light source in parallel with a fourth light source. Each of the third light source and the fourth light source have an anode and a cathode. The anode of the first light source is electrically connected to the cathode of the second light source, the anode of said third light source, and the cathode of said fourth light source. The anode of the third light source is electrically connected to the cathode of the fourth light source.08-08-2013
20130211261MOTION COMPENSATION AND PATIENT FEEDBACK IN MEDICAL IMAGING SYSTEMS - An optical motion sensing system (08-15-2013

Patent applications in class Visible light radiation

Patent applications in all subclasses Visible light radiation