Inventors list

Assignees list

Classification tree browser

Top 100 Inventors

Top 100 Assignees


Blood glucose

Subclass of:

600 - Surgery

600300000 - DIAGNOSTIC TESTING

600309000 - Measuring or detecting nonradioactive constituent of body liquid by means placed against or in body throughout test

600345000 - Electroanalysis

Patent class list (only not empty are listed)

Deeper subclasses:

Entries
DocumentTitleDate
20130030271SENSOR FOR MEASURING THE ACTIVITY OF BETA-PANCREATIC CELLS OR OF ISLETS OF LANGERHANS, MANUFACTURE AND USE OF SUCH A SENSOR - The invention relates to a sensor (01-31-2013
20100049022Methods for improving performance and reliability of biosensors - The present invention relates to a predictive-kinetic method for use with data processing of a sensor-generated signal, as well as, microprocessors and monitoring systems employing such a predictive-kinetic method. Data from a transient region of a signal is used with suitable models and curve-fitting methods to predict the signal that would be measured for the system at the completion of the reaction. The values resulting from data processing of sensor response using the methods of the present invention are less sensitive to measurement variables.02-25-2010
20100076289Health Monitor - Methods and devices to detect analyte in body fluid are provided. Embodiments include enhanced analyte monitoring devices and systems.03-25-2010
20100076288Method and System for Transferring Analyte Test Data - A system for transferring data includes an analyte test instrument (ATI) adapted to store data, a wirelessly enabled data management device (DMD) for comprehensively analyzing data, and an adaptor removably connected to the ATI for transferring data stored on the ATI to the DMD. The adaptor includes a data communication device capable of removable connection with the ATI, a microprocessor electrically connected to the data communication device, a wireless controller electrically connected to the microprocessor and a wireless transceiver electrically connected to the wireless controller. In use, data transfer is executed between the ATI and the DMD by electrically and mechanically connecting the adaptor to the ATI. Data stored on the ATI is then automatically downloaded into adaptor memory. Upon completion of the download, the user activates an externally accessible input device on the adaptor which, in turn, wirelessly transmits data from the adaptor memory to the DMD.03-25-2010
20100076287Small Volume In Vitro Analyte Sensor and Methods of Making - A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry; and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.03-25-2010
20100076285Small Volume In Vitro Sensor and Methods of Making - A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry; and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.03-25-2010
20100076286Small Volume In Vitro Analyte Sensor and Methods of Making - A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry; and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.03-25-2010
20100145172OXYGEN ENHANCING MEMBRANE SYSTEMS FOR IMPLANTABLE DEVICES - The present invention relates generally to systems and methods for increasing oxygen availability to implantable devices. The preferred embodiments provide a membrane system configured to provide protection of the device from the biological environment and/or a catalyst for enabling an enzymatic reaction, wherein the membrane system includes a polymer formed from a high oxygen soluble material. The high oxygen soluble polymer material is disposed adjacent to an oxygen-utilizing source on the implantable device so as to dynamically retain high oxygen availability to the oxygen-utilizing source during oxygen deficits. Membrane systems of the preferred embodiments are useful for implantable devices with oxygen-utilizing sources and/or that function in low oxygen environments, such as enzyme-based electrochemical sensors and cell transplantation devices.06-10-2010
20090156920LAYERED SENSOR FOR DETERMINING AN ANALYTE CONCENTRATION - An implantable sensor is provide which can be used for determining a concentration of at least one analyte in a medium, in particular a body tissue and/or a body fluid. The implantable sensor has a layered construction with at least one insulating carrier substrate and at least two electrodes which are arranged in at least two different layer planes of the implantable sensor and are electrically isolated from one another by the at least one insulating carrier substrate. The electrodes have electrode areas which face the medium when the sensor has been implanted, and are in contact with the medium over a large area and substantially uniformly, directly or via a generally analyte-permeable membrane layer.06-18-2009
20100105999Graphical User Interface for Glucose Monitoring System - Graphical user interfaces (GUIs) for a medical device such as a blood glucose meter, systems and methods are provided. Embodiments include GUIs in which a user may navigate between icons and select certain display outputs which summarize all or certain glucose data over particular time periods. In certain embodiments, animated icons and/or graphs and/or text summaries may be provided.04-29-2010
20100030048Subcutaneous Glucose Electrode - A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode is designed to allow “one-point” in vivo calibration, i.e., to have zero output current at zero glucose concentration, even in the presence of other electroreactive species of serum or blood. The electrode is preferably three or four-layered, with the layers serially deposited within a recess upon the tip of a polyamide insulated gold wire. A first glucose concentration-to-current transducing layer is overcoated with an electrically insulating and glucose flux limiting layer (second layer) on which, optionally, an immobilized interference-eliminating horseradish peroxidase based film is deposited (third layer). An outer (fourth) layer is biocompatible.02-04-2010
20100331648CALIBRATION TECHNIQUES FOR A CONTINUOUS ANALYTE SENSOR - Disclosed herein are systems and methods for calibrating a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes one or more electrodes to measure an additional analyte. Such measurements may provide a baseline or sensitivity measurement for use in calibrating the sensor. Furthermore, baseline and/or sensitivity measurements may be used to trigger events such as digital filtering of data or suspending display of data.12-30-2010
20120165637Method of Calibrating an Analyte-Measurement Device, and Associated Methods, Devices and Systems - The invention relates to a method for calibrating an analyte-measurement device that is used to evaluate a concentration of analyte in bodily fluid at or from a measurement site in a body. The method involves measuring a concentration, or calibration concentration, of an analyte in blood from an “off-finger” calibration site, and calibrating the analyte-measurement device based on that calibration concentration. The invention also relates to a device, system, or kit for measuring a concentration of an analyte in a body, which employs a calibration device for adjusting analyte concentration measured in bodily fluid based on an analyte concentration measured in blood from an “off-finger” calibration site.06-28-2012
20090093695BIOSENSOR - There is provided a biosensor (which is integrated with a needle) with a high precision where an assembling is easy and reproducibility of the prepared biosensor (integrated with a needle) is good.04-09-2009
20110015510Analyte Monitoring Device and Methods of Use - An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.01-20-2011
20110015509Analyte Monitoring and Management System and Methods Therefor - Method and apparatus for providing multiple data receiver units in a data monitoring and management system such as analyte monitoring system where a first data receiver includes all of the functionalities for the data monitoring and management system receiver unit, and a second data receiver unit is configured with a limited functions to provide application specific convenience to the user or patient is disclosed.01-20-2011
20120226121CALIBRATION TECHNIQUES FOR A CONTINUOUS ANALYTE SENSOR - Disclosed herein are systems and methods for calibrating a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes one or more electrodes to measure an additional analyte. Such measurements may provide a baseline or sensitivity measurement for use in calibrating the sensor. Furthermore, baseline and/or sensitivity measurements may be used to trigger events such as digital filtering of data or suspending display of data.09-06-2012
20130066178Lyotropic Liquid Crystal Coated Analyte Monitoring Device and Methods of Use - The present invention is directed to membranes composed liquid crystals having continuous aqueous channels, such as a lyotropic liquid crystal, including a cubic phase lyotropic liquid crystal, and to electrochemical sensors equipped with such membranes. The membranes are useful in limiting the diffusion of an analyte to a working electrode in an electrochemical sensor so that the sensor does not saturate and/or remains linearly responsive over a large range of analyte concentrations. Electrochemical sensors equipped with membranes of the present invention demonstrate considerable sensitivity and stability, and a large signal-to-noise ratio, in a variety of conditions.03-14-2013
20130066179Integrated Lancet and Analyte Testing Apparatus - Integrated lancing and analyte measurement systems are provided which minimize the number of actions required to operate the systems, accomplished in part by combining two or more user steps into one.03-14-2013
20110021895Subcutaneous Glucose Electrode - A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode is designed to allow “one-point” in vivo calibration, i.e., to have zero output current at zero glucose concentration, even in the presence of other electroreactive species of serum or blood. The electrode is preferably layered, with the layers serially deposited within a recess upon the tip of a polyamide insulated gold wire. A first glucose concentration-to-current transducing layer can be overcoated with an electrically insulating and glucose flux limiting layer (second layer) on which, optionally, an immobilized interference-eliminating horseradish peroxidase based film is deposited. An outer layer is preferably biocompatible.01-27-2011
20100081908ANALYTE SENSOR - The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.04-01-2010
20100081907Small Volume In Vitro Analyte Sensor and Methods of Making - A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.04-01-2010
20100081906Analyte Sensor Sensitivity Attenuation Mitigation - Method and apparatus for receiving a first signal from a first working electrode of a glucose sensor positioned at a first predetermined position under the skin layer, receiving a second signal from a second working electrode of the glucose sensor positioned at a second predetermined position under the skin layer, the second signal received substantially contemporaneous to receiving the first signal, detecting a dropout in the signal level associated with one of the first or second signals, comparing the first signal and the second signal to determine a variation between the first and second signals, and confirming one of the first or second signals as a valid glucose sensor signal output when the determined variation between the first and the second signals is less than a predetermined threshold level are provided.04-01-2010
20100081905ANALYTE SENSORS COMPRISING LEVELING AGENTS - Generally, embodiments of the invention relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have improved uniformity of distribution of one or more components of the sensor by inclusion of a low surface tension polymer leveling agent, where the components are disposed proximate to a working electrode of in vivo and/or in vitro analyte sensors, e.g., continuous and/or automatic in vivo monitoring using analyte sensors and/or test strips. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.04-01-2010
20090012379SYSTEM AND METHODS FOR PROCESSING ANALYTE SENSOR DATA - Systems and methods for processing sensor analyte data, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. During initial calibration, the analyte sensor data is evaluated over a period of time to determine stability of the sensor. The sensor may be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. The calibration may be updated after evaluating the calibration set for best calibration based on inclusion criteria with newly received reference analyte data. Fail-safe mechanisms are provided based on clinical acceptability of reference and analyte data and quality of sensor calibration. Algorithms provide for optimized prospective and retrospective analysis of estimated blood analyte data from an analyte sensor.01-08-2009
20090143660TRANSCUTANEOUS ANALYTE SENSOR - The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.06-04-2009
20100087722Small Volume In Vitro Analyte Sensor and Methods of Making - A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.04-08-2010
20090024015SENSING ELEMENT HAVING AN ADHESIVE BACKING - The present invention is directed to a sensing element that comprises a flexible substrate having first and second opposite surfaces; at least one sensor disposed on the first surface of the flexible substrate; an adhesive layer substantially covering the second surface of the flexible substrate; and a release liner releasably adhered to the adhesive layer so that upon removal of the release liner the adhesive layer is exposed for securing the sensing element to the catheter. The release liner permits the sensing element to be positioned at a desired location within the catheter after which the release liner can be removed to expose the adhesive layer. The adhesive layer can then be used to attach and secure the sensing element at a desired location on the catheter. As a result, the need for additional adhesives can be reduced or eliminated.01-22-2009
20120238850Integrated Sensor for Analyzing Biological Samples - An integrated lancet and testing striplet for measuring a body analyte level in a health care regimen includes a skin piercing member and an analyte sensor coupled together.09-20-2012
20090203978Analyte Monitoring Device and Methods of Use - An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.08-13-2009
20080287760 METHOD OF MAKING AN ELECTROCHEMICAL SENSOR - A process for the manufacture of small sensors with reproducible surfaces, including electrochemical sensors. One process includes forming channels in the surface of a substrate and disposing a conductive material in the channels to form an electrode. The conductive material can also be formed on the substrate by other impact and non-impact methods. In a preferred embodiment, the method includes cutting the substrate to form a sensor having a connector portion and a transcutaneous portion, the two portions having edges that define one continuous straight line.11-20-2008
20110282172LONG-TERM IMPLANTABLE BIOSENSOR - Embodiments provide an analyte sensing device having one or more indicating electrodes adapted for long-term use within an individual. An indicating electrode coupled with a reference electrode may be inserted within or below the dermis of an individual and may be electrically coupled to an external sensor unit. Related analyte sensor insertion aids and methods of using the disclosed embodiments are also provided.11-17-2011
20100331647LONG TERM ANALYTE SENSOR ARRAY - A long term analyte sensor for measuring at least one analyte in the body of a user and which includes a housing, a plurality of analyte contacting sensor elements and at least one structure for relaying information away from the sensor. This plurality of analyte contacting sensor elements are typically disposed in an array. The analyte sensor further includes at least one sensor protection membrane that is controllable in a manner such that sensor elements may be activated (e.g. exposed to the external environment) at different times so as to extend the useful life of the sensor. In illustrative analyte sensors, the analyte is glucose.12-30-2010
20110288388MULTI-CONDUCTOR LEAD CONFIGURATIONS USEFUL WITH MEDICAL DEVICE SYSTEMS AND METHODS FOR MAKING AND USING THEM - A multiple-conductor electrical lead for use with medical device systems and a method of manufacture is disclosed. The multiple-conductor electrical lead comprises a central core and has at least one conductor, typically in the form of a ribbon cable, coiled around it along its length. Typically one or more ribbon cables coiled around a central core each comprise a plurality of separate electrical conductors both coupled together along their lengths in series and electrically insulated from one another with an insulating material. The material of the central core, e.g. polyester, stainless steel, nickel titanium, and the structural configuration, e.g. wrapping pitch of the ribbon cable around the central core and number of ribbon cables, are selected based on desired mechanical characteristics. Such multiple-conductor electrical leads are useful, for example, with analyte sensor systems such as amperometric glucose sensor systems used in the management of diabetes.11-24-2011
20100036220Small Volume In Vitro Sensor and Methods of Making - A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.02-11-2010
20090099435Analyte Monitoring Device and Methods of Use - An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.04-16-2009
20090099436DUAL ELECTRODE SYSTEM FOR A CONTINUOUS ANALYTE SENSOR - Disclosed herein are systems and methods for a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes first and second working electrodes to measure additional analyte or non-analyte related signal. Such measurements may provide a background and/or sensitivity measurement(s) for use in processing sensor data and may be used to trigger events such as digital filtering of data or suspending display of data.04-16-2009
20100268050Analyte Monitoring Device and Methods of Use - An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.10-21-2010
20090149728BLOOD CONTACTING SENSOR - The invention provides methods and apparatus for detecting an analyte in blood. The apparatus is particularly suited for bringing a sensor into direct contact with blood in vivo. The apparatus comprises a sensor that detects the presence of an analyte and an assembly means. The assembly means has a sensor end, wherein the sensor end of the assembly means is affixed to the sensor, and the assembly means is adapted for coupling with a venous flow device. By coupling with a venous flow device, the assembly means brings the sensor into direct contact with blood flowing through the venous flow device. Examples of venous flow devices that bring the sensor into direct contact with the blood of a subject include, but are not limited to, intravenous catheters and external blood loops, such as are used in extra corporeal membrane oxygenation or hemodialysis.06-11-2009
20100121165Subcutaneous Glucose Electrode - A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode is designed to allow “one-point” in vivo calibration, i.e., to have zero output current at zero glucose concentration, even in the presence of other electroreactive species of serum or blood. The electrode is preferably three or four-layered, with the layers serially deposited within a recess upon the tip of a polyamide insulated gold wire. A first glucose concentration-to-current transducing layer is overcoated with an electrically insulating and glucose flux limiting layer (second layer) on which, optionally, an immobilized interference-eliminating horseradish peroxidase based film is deposited (third layer). An outer (fourth) layer is biocompatible.05-13-2010
20100121169CELLULOSIC-BASED INTERFERENCE DOMAIN FOR AN ANALYTE SENSOR - The present invention relates generally to devices for measuring an analyte in a host. More particularly, the present invention relates to devices for measurement of glucose in a host that incorporate a cellulosic-based interference domain.05-13-2010
20100121168Method and System for Transferring Analyte Test Data - A system for transferring data includes an analyte test instrument (ATI) adapted to store data, a wirelessly enabled data management device (DMD) for comprehensively analyzing data, and an adaptor removably connected to the ATI for transferring data stored on the ATI to the DMD. The adaptor includes a data communication device capable of removable connection with the ATI, a microprocessor electrically connected to the data communication device, a wireless controller electrically connected to the microprocessor and a wireless transceiver electrically connected to the wireless controller. In use, data transfer is executed between the ATI and the DMD by electrically and mechanically connecting the adaptor to the ATI. Data stored on the ATI is then automatically downloaded into adaptor memory. Upon completion of the download, the user activates an externally accessible input device on the adaptor which, in turn, wirelessly transmits data from the adaptor memory to the DMD.05-13-2010
20100121167Alarm Characterization for Analyte Monitoring Devices and Systems - Methods and apparatus including determining a rate of occurrence of a glycemic excursion event, determining a frequency of an alarm activation associated with the glycemic excursion event, determining an analyte level associated with the alarm activation, and setting an alarm parameter based on one or more of the determined rate of occurrence of the glycemic excursion event, the frequency of the alarm activation associated with the glycemic excursion event or the determined analyte level are provided.05-13-2010
20090093696Analyte Monitoring Device and Methods of Use - An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.04-09-2009
20120108931Calibration of Analyte Measurement System - A method of calibrating an analyte measurement system is provided.05-03-2012
20100099971DEVICE AND METHOD FOR DETERMINING ANALYTE LEVELS - Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices, that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices comprise a unique microarchitectural arrangement in the sensor region that allows accurate data to be obtained over long periods of time.04-22-2010
20100099970DEVICE AND METHOD FOR DETERMINING ANALYTE LEVELS - Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices, that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices comprise a unique microarchitectural arrangement in the sensor region that allows accurate data to be obtained over long periods of time.04-22-2010
20110201910INTEGRATED RECEIVER FOR CONTINUOUS ANALYTE SENSOR - A system is provided for monitoring glucose in a host, including a continuous glucose sensor that produces a data stream indicative of a host's glucose concentration and an integrated receiver that receives the data stream from the continuous glucose sensor and calibrates the data stream using a single point glucose monitor that is integral with the integrated receiver. The integrated receiver obtains a glucose value from the single point glucose monitor, calibrates the sensor data stream received from the continuous glucose sensor, and displays one or both of the single point glucose measurement values and the calibrated continuous glucose sensor values on the user interface.08-18-2011
20090281405METHOD FOR NON-INVASIVELY DETERMINING THE RELATIVE LEVELS OF TWO BIOLOGICAL SUBSTANCES - An iontophoretic sampling device for non-invasively determining the relative levels of two substances present in a biological system.11-12-2009
20090043182SIGNAL PROCESSING FOR CONTINUOUS ANALYTE SENSOR - Systems and methods for dynamically and intelligently estimating analyte data from a continuous analyte sensor, including receiving a data stream, selecting one of a plurality of algorithms, and employing the selected algorithm to estimate analyte values. Additional data processing includes evaluating the selected estimative algorithms, analyzing a variation of the estimated analyte values based on statistical, clinical, or physiological parameters, comparing the estimated analyte values with corresponding measure analyte values, and providing output to a user. Estimation can be used to compensate for time lag, match sensor data with corresponding reference data, warn of upcoming clinical risk, replace erroneous sensor data signals, and provide more timely analyte information encourage proactive behavior and preempt clinical risk.02-12-2009
20090043181SIGNAL PROCESSING FOR CONTINUOUS ANALYTE SENSOR - Systems and methods for dynamically and intelligently estimating analyte data from a continuous analyte sensor, including receiving a data stream, selecting one of a plurality of algorithms, and employing the selected algorithm to estimate analyte values. Additional data processing includes evaluating the selected estimative algorithms, analyzing a variation of the estimated analyte values based on statistical, clinical, or physiological parameters, comparing the estimated analyte values with corresponding measure analyte values, and providing output to a user. Estimation can be used to compensate for time lag, match sensor data with corresponding reference data, warn of upcoming clinical risk, replace erroneous sensor data signals, and provide more timely analyte information encourage proactive behavior and preempt clinical risk.02-12-2009
20090292189Analyte Monitoring Device and Methods of Use - An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.11-26-2009
20120296186Analyte Sensors Having a Membrane with Low Temperature Sensitivity - Embodiments of the present disclosure relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have a membrane with low temperature sensitivity. The sensing layer is disposed on a working electrode of in vivo and/or in vitro analyte sensors, e.g., continuous and/or automatic in vivo monitoring using analyte sensors and/or test strips. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.11-22-2012
20080249384System and Method for Estimating the Glucose Concentration in Blood - This application relates to glucose monitoring systems for continuously measuring the glucose concentration in a patients blood. The system is adapted to communicate with one or more sensors (10-09-2008
20080281178TRANSDERMAL ANALYTE MONITORING SYSTEMS AND METHODS FOR ANALYTE DETECTION - Transdermal analyte monitoring systems (TAMS) having increased longevity and improved analyte detection are described herein. Kits for use with the TAMS and methods of using the TAMS and kits are also described. In a preferred embodiment, the TAMS includes a protective, semi-permeable membrane covering the surface of the hydrogel. The protective, semi-permeable membrane contacts with the skin of a user and prevents contamination or fouling of the hydrogel. Optionally, the hydrogel comprises one or more humectants and/or an immobilized enzyme. In another preferred embodiment, the TAMS contains at least one channel or pocket for increasing the amount of oxygen provided to the hydrogel. In one embodiment, a method for improving analyte detection by the TAMS is provided. For example, after the skin porosity is increased by an appropriate pretreatment, a skin preparation wipe is applied to the treated skin area and then the TAMS is applied to the treated area.11-13-2008
20080281176METHOD OF MAKING AN ELECTROCHEMICAL SENSOR - A process for the manufacture of small sensors with reproducible surfaces, including electrochemical sensors. One process includes forming channels in the surface of a substrate and disposing a conductive material in the channels to form an electrode. The conductive material can also be formed on the substrate by other impact and non-impact methods. In a preferred embodiment, the method includes cutting the substrate to form a sensor having a connector portion and a transcutaneous portion, the two portions having edges that define one continuous straight line.11-13-2008
20080281177 METHOD OF MAKING AN ELECTROCHEMICAL SENSOR - A process for the manufacture of small sensors with reproducible surfaces, including electrochemical sensors. One process includes forming channels in the surface of a substrate and disposing a conductive material in the channels to form an electrode. The conductive material can also be formed on the substrate by other impact and non-impact methods. In a preferred embodiment, the method includes cutting the substrate to form a sensor having a connector portion and a transcutaneous portion, the two portions having edges that define one continuous straight line.11-13-2008
20080281175METHOD OF MAKING AN ELECTROCHEMICAL SENSOR - A process for the manufacture of small sensors with reproducible surfaces, including electrochemical sensors. One process includes forming channels in the surface of a substrate and disposing a conductive material in the channels to form an electrode. The conductive material can also be formed on the substrate by other impact and non-impact methods. In a preferred embodiment, the method includes cutting the substrate to form a sensor having a connector portion and a transcutaneous portion, the two portions having edges that define one continuous straight line.11-13-2008
20080287759 METHOD OF MAKING AN ELECTROCHEMICAL SENSOR - A process for the manufacture of small sensors with reproducible surfaces, including electrochemical sensors. One process includes forming channels in the surface of a substrate and disposing a conductive material in the channels to form an electrode. The conductive material can also be formed on the substrate by other impact and non-impact methods. In a preferred embodiment, the method includes cutting the substrate to form a sensor having a connector portion and a transcutaneous portion, the two portions having edges that define one continuous straight line.11-20-2008
20120296187Devices and Methods for Obtaining Analyte Sample - Devices, systems and methods for accessing bodily fluid beneath the skin surface by abrading the skin, whereby such bodily fluid may be extracted for ex vivo analysis or whereby an in vivo analyte sensor is implanted at the abrasion site.11-22-2012
20080281179ANALYTE MONITORING SYSTEM AND METHODS - Methods and systems for providing data communication in medical systems are disclosed.11-13-2008
20080208025LOW OXYGEN IN VIVO ANALYTE SENSOR - The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous and subcutaneous measurement of glucose in a host.08-28-2008
20100298680METHOD AND DEVICE FOR DETERMINING A PROPERTY OF LIVING TISSUE - The invention relates to a measurement of tissue properties, in particular glucose, by measuring the response of the tissue to an applied electric field. The tissue is modeled by a System of homogeneous layers. In one approach, a plurality of electrical fields are generated in the tissue at different frequencies. For each of the fields, a signal depending on the dielectric permittivity as seen by the electrode arrangement at the frequency is measured, thereby generating a measured dataset. In another approach the different electrode configurations can be used to achieve different penetration depths in the desired layers. A function is then fitted to the dataset by varying at least some parameters of the function. These parameters describe the dispersion of the dielectric permittivity of a plurality of layers in the tissue. At least part of the parameters obtained in this fitting procedure are then used for determining the desired tissue property. Furthermore a combination of these two approaches can be used to optimize the uniqueness of the Solution of the fitting procedure for changes at a specific depth.11-25-2010
20100030050Subcutaneous Glucose Electrode - A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode is designed to allow “one-point” in vivo calibration, i.e., to have zero output current at zero glucose concentration, even in the presence of other electroreactive species of serum or blood. The electrode is preferably three or four-layered, with the layers serially deposited within a recess upon the tip of a polyamide insulated gold wire. A first glucose concentration-to-current transducing layer is overcoated with an electrically insulating and glucose flux limiting layer (second layer) on which, optionally, an immobilized interference-eliminating horseradish peroxidase based film is deposited (third layer). An outer (fourth) layer is biocompatible.02-04-2010
20100004522Continuously Wearable Compact Blood Glucose Measuring Device - A wearable blood glucose measuring device based device and kit that incorporates non-continuous, invasive, electrochemical glucose test strip technologies for measuring blood glucose concentrations. The device can be inconspicuously worn due to its compact nature and integration into commonly worn articles such as watches, bracelets, armbands, wristbands, and the like. All-in-one embodiments include integrated test strip management including automatic test strip dispensing/ejection as well as incorporating spring loaded lancet apparatus capable of the dispensing, arming and activating functions enabling the user to provide a blood sample for glucose testing. Some embodiments do not integrate, nor contain any lancing devices/lancets. Other embodiments contain secure storage compartments integrated into the wearable blood glucose measuring device where the user can choose to store loose glucose test strips, calibration strips, lancets, cleaning wipes, and any combination thereof.01-07-2010
20110144466Catheter-Free Implantable Needle Biosensor - Electrochemical biosensors consisting of two or more needle-shaped electrodes for monitoring of molecules such as glucose in the subcutaneous tissue are provided. The two electrodes are parallel to each other, and are fixed perpendicularly to the planar side of a sensor base which provides skin fixation and electric connection. The needle electrodes are made of rigid conducting materials, capable of inserting into the skin without the need of catheters. One electrode is the sensing electrode and the other, the reference electrode. A compound sensing membrane is attached onto the sensing electrode surface to detect analyzed molecules.06-16-2011
20120197099Analyte Meter Including an RFID Reader - A glucose monitoring system, includes a glucose sensor strip or package of strips. The strip includes a substrate and a glucose monitoring circuit that has electrodes and a bodily fluid application portion of selected chemical composition. An antenna is integrated with the glucose sensor strip. A RFID sensor chip is coupled with the glucose sensor strip and the antenna. The chip has a memory containing digitally-encoded data representing calibration and/or expiration date information for the strip.08-02-2012
20090177067Glucose Sensor and Glucose Level Measuring Apparatus - The present invention relates to a glucose sensor (07-09-2009
20110144464Integrated Transmitter Unit and Sensor Introducer Mechanism and Methods of Use - Method and apparatus for providing an integrated transmitter unit and sensor insertion mechanism is provided.06-16-2011
20080319292ANALYTE MONITORING DEVICE AND METHODS OF USE - An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.12-25-2008
20090326355Integrated Test System for Monitoring Bodily Fluids - An integrated diagnostic instrument (12-31-2009
20110224521NON-INVASIVE METHOD FOR ESTIMATING OF THE VARIATION OF THE GLUCOSE LEVEL IN THE BLOOD OF A PERSON AND APPARATUS FOR CARRYING OUT THE METHOD - The estimation of the variation of the glucose level in the blood of a person by the variation of the volume of the interstitial fluid compartments in muscular tissue due to a shift of fluid between the extracellular and intracellular compartments caused by variations of the osmotic pressure of the extracellular fluids which is in turn correlated with the glucose level. The variation of the volume of the interstitial fluid compartments is detected by a non-invasive conductometry measurement using electrodes placed in contact with the skin of the person overlying a portion of soft tissue including muscular fibers. To eliminate the adverse effect of the conductivity of the capillary vessels, the conductivity of the tissue is measured independently in two directions, namely parallel and transverse to the muscular fibers.09-15-2011
20090198117ANALYTE SENSORS HAVING NANOSTRUCTURED ELECTRODES AND METHODS FOR MAKING AND USING THEM - Embodiments of the invention provide analyte sensors having nanostructured electrodes as well as methods for making and using such sensors. In certain embodiments of the invention, the sensor includes a carbon nanotube electrode and a analyte limiting membrane that modulates the ability of a analyte to contact the carbon nanotube electrode.08-06-2009
20090062634ANALYTE MONITORING DEVICE AND METHODS OF USE - An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.03-05-2009
20080262330Analyte Sensors and Compositions for Use Therein - The present invention relates to analyte sensors and compositions, membranes for use in analyte sensors. For example, an analyte sensor is provided that comprise an electrode surface comprising an enzyme; an a biocompatible analyte permeable composition comprising a nitric oxide generating agent.10-23-2008
20090137889Subcutaneous Glucose Electrode - A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode is designed to allow “one-point” in vivo calibration, i.e., to have zero output current at zero glucose concentration, even in the presence of other electroreactive species of serum or blood. The electrode is preferably layered, with the layers serially deposited within a recess upon the tip of a polyamide insulated gold wire. A first glucose concentration-to-current transducing layer can be overcoated with an electrically insulating and glucose flux limiting layer (second layer) on which, optionally, an immobilized interference-eliminating horseradish peroxidase based film is deposited. An outer layer is preferably biocompatible.05-28-2009
20090198118Analyte Sensor with Time Lag Compensation - Methods and devices and systems for determining an analyte value are disclosed.08-06-2009
20110230741METHODS AND SYSTEMS FOR OBSERVING SENSOR PARAMETERS - The invention disclosed herein provides methods and materials for observing the state of a sensor, for example those used by diabetic patients to monitor blood glucose levels. Typically a voltage such as a voltage pulse is applied to the sensor in order to solicit a current response from which for example, factors such as impedance values can be derived. Such values can then be used as indicators of a sensor's state, for example the state of sensor hydration, sensor noise, sensor offset, sensor drift or the like.09-22-2011
20090203979IMPLANTABLE SENSOR ELECTRODES AND ELECTRONIC CIRCUITRY - An electronic circuit for sensing an output of a sensor having at least one electrode pair and circuitry for obtaining and processing the sensor output. The electrode pair may be laid out such that one electrode is wrapped around the other electrode in a U-shaped fashion. The electronic circuitry may include, among other things, a line interface for interfacing with input/output lines, a rectifier in parallel with the line interface, a counter connected to the line interface and a data converter connected to the counter and the electrode pair. The data converter may be a current-to-frequency converter. In addition, the rectifier may derive power for the electronic circuit from communication pulses received on the input/output lines.08-13-2009
20090247856POLYMER MEMBRANES FOR CONTINUOUS ANALYTE SENSORS - Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the device has a sensing mechanism and a sensing membrane that includes at least one surface-active group-containing polymer and that is located over the sensing mechanism. The sensing membrane may have a bioprotective layer configured to substantially block the effect and/or influence of non-constant noise-causing species.10-01-2009
20100274112Modular Combination Of Medication Infusion And Analyte Monitoring - Methods and systems for providing modular components in an integrated infusion device and analyte monitoring system where the components are independently replaceable are provided.10-28-2010
20090318790BLOOD SENSOR AND BLOOD EXAMINING INSTRUMENT INCLUDING SAME - A blood sensor (12-24-2009
20100152561RF Tag on Test Strips, Test Strip Vials and Boxes - A glucose monitoring system, includes a glucose sensor strip or package of strips. The strip includes a substrate and a glucose monitoring circuit that has electrodes and a bodily fluid application portion of selected chemical composition. An antenna is integrated with the glucose sensor strip. A RFID sensor chip is coupled with the glucose sensor strip and the antenna. The chip has a memory containing digitally-encoded data representing calibration and/or expiration date information for the strip.06-17-2010
20100185071DUAL ELECTRODE SYSTEM FOR A CONTINUOUS ANALYTE SENSOR - Disclosed herein are systems and methods for a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes first and second working electrodes to measure analyte or non-analyte related signal, both of which electrode include an interference domain.07-22-2010
20100191084SENSOR WITH LAYERED ELECTRODES - A thin film sensor, such as a glucose sensor, is provided for transcutaneous placement at a selected site within the body of a patient. The sensor includes several sensor layers that include conductive layers and includes a proximal segment defining conductive contacts adapted for electrical connection to a suitable monitor, and a distal segment with sensor electrodes for transcutaneous placement. The sensor electrode layers are disposed generally above each other, for example with the reference electrode above the working electrode and the working electrode above the counter electrode. The electrode layers are separated by dielectric layer.07-29-2010
20080214918DUAL ELECTRODE SYSTEM FOR A CONTINUOUS ANALYTE SENSOR - Disclosed herein are systems and methods for a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes first and second working electrodes to measure additional analyte or non-analyte related signal. Such measurements may provide a background and/or sensitivity measurement(s) for use in processing sensor data and may be used to trigger events such as digital filtering of data or suspending display of data.09-04-2008
20100152562RF Tag on Test Strips, Test Strip Vials and Boxes - A glucose monitoring system, includes a glucose sensor strip or package of strips. The strip includes a substrate and a glucose monitoring circuit that has electrodes and a bodily fluid application portion of selected chemical composition. An antenna is integrated with the glucose sensor strip. A RFID sensor chip is coupled with the glucose sensor strip and the antenna. The chip has a memory containing digitally-encoded data representing calibration and/or expiration date information for the strip.06-17-2010
20100240975SYSTEMS AND METHODS FOR REPLACING SIGNAL ARTIFACTS IN A GLUCOSE SENSOR DATA STREAM - Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as ischemia, pH changes, temperatures changes, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system replaces some or the entire data stream continually or intermittently including signal estimation methods that particularly address transient signal artifacts. The system is also capable of detecting the severity of the signal artifacts and selectively applying one or more signal estimation algorithm factors responsive to the severity of the signal artifacts, which includes selectively applying distinct sets of parameters to a signal estimation algorithm or selectively applying distinct signal estimation algorithms.09-23-2010
20100240976SYSTEMS AND METHODS FOR REPLACING SIGNAL ARTIFACTS IN A GLUCOSE SENSOR DATA STREAM - Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as ischemia, pH changes, temperatures changes, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system replaces some or the entire data stream continually or intermittently including signal estimation methods that particularly address transient signal artifacts. The system is also capable of detecting the severity of the signal artifacts and selectively applying one or more signal estimation algorithm factors responsive to the severity of the signal artifacts, which includes selectively applying distinct sets of parameters to a signal estimation algorithm or selectively applying distinct signal estimation algorithms.09-23-2010
20090076357Methods and Apparatuses for Navigating the Subaracnhnoid Space - Disclosed is a method of navigating a spinal subarachnoid space in a living being, that includes percutaneously introducing a device into the spinal subarachnoid space at an entry location. The device has a first passageway that is sized to slidably receive, and work with, at least a guidewire. The device can be a catheter or a sheath. The method can also include advancing the device within the spinal subarachnoid space at least more than 10 centimeters from the entry location. Alternatively, the method can include advancing the device within the spinal subarachnoid space to facilitate intracranial access with a second device introduced through the first passageway. Also disclosed is a device suited for attachment to a patient's skin, such as a sheath, that includes an elongated member, a skin-attachment apparatus having a flexible skin-attachment flap, and a valve apparatus.03-19-2009
20090076356DUAL ELECTRODE SYSTEM FOR A CONTINUOUS ANALYTE SENSOR - Disclosed herein are systems and methods for a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes first and second working electrodes to measure analyte or non-analyte related signal, both of which electrode include an interference domain.03-19-2009
20090076355Method And Apparatus For Providing Rechargeable Power In Data Monitoring And Management Systems - Method and apparatus for charging a power supply unit such as a rechargeable battery for use in data monitoring and management system using the ESD protection circuitry of the existing electrode contacts including guard contact and counter electrode thereby reducing system cost, complexity, and any unprotected battery contacts exposed for potential contamination is provided.03-19-2009
20100210932METHOD OF ANALYZING AN ANALYTE - A method of using a diffusion-based, continuous-monitoring system to analyze an analyte includes creating at least one diffusion channel in an area of skin. The diffusion channel is maintained for a desired duration. The levels of the analyte are continuously monitored for the desired duration via a diffusion-based, continuous-monitoring device. The levels of the analyte at the area of skin are analyzed to determine if a condition associated with the analyte is present.08-19-2010
20110046466Analyte Sensors Including Nanomaterials and Methods of Using Same - Generally, embodiments of the invention relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have improved uniformity of distribution of one or more components, improved stability, and improved response time of the sensor by inclusion of a nanomaterial, such as inert inorganic nanomaterials, where the components are disposed proximate to a working electrode of in vivo and/or in vitro analyte sensors, e.g., continuous and/or automatic in vivo monitoring using analyte sensors and/or test strips. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.02-24-2011
20090105568Assessing Measures Of Glycemic Variability - Methods, devices and systems for receiving an instruction to determine a glycemic variation level, retrieving a stored metric for determining the glycemic variation level, retrieving one or more parameters associated with the retrieved metric analysis, determining the glycemic variation level based on the retrieved one or more parameters for the retrieved metric analysis, and outputting the determined glycemic variation level when it is determined that the retrieved one or more parameters associated with the retrieved metric analysis meets a predetermined condition are disclosed.04-23-2009
20090069658Analyte Monitoring Device and Methods of Use - An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.03-12-2009
20090069657Analyte Monitoring Device and Methods of Use - An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.03-12-2009
20090069655Analyte Monitoring Device and Methods of Use - An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.03-12-2009
20090069656Analyte Monitoring Device and Methods of Use - An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.03-12-2009
20100331646Health Management Devices and Methods - Methods and devices to detect analyte in body fluid are provided. Embodiments include analyte sensors designed so that at least a portion of the sensor is positionable beneath a skin surface during analyte monitoring.12-30-2010
20110040163ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY ENABLED CONTINUOUS GLUCOSE MONITORING SENSOR SYSTEMS - The use of electrical impedance spectroscopy to adjust calibration settings in an in vivo monitoring system, such as an in vivo continuous glucose monitoring sensor. The adjustments can compensate for the condition of the sensor membrane in vivo.02-17-2011
20110034791Method and Device for Utilizing Analyte Levels to Assist in the Treatment of Diabetes - A health-monitoring device assesses the health of a user based on levels of two analytes in a biological fluid. A first analyte that is utilized to assess a user's health is a fat metabolism analyte, such as ketones, free fatty acids and glycerol, which is indicative of fat metabolism. A second analyte that is utilized is a glucose metabolism analyte, such as glucose. The levels of the two analytes may be used to assess insulin sensitivity, to detect both recent hypoglycemia and the cause of high glucose levels, and/or to guide therapeutic intervention. The dual analyte model may calculate a discrepancy between an actual insulin activity level and a theoretical insulin activity level. The dual analyte model of the present invention may be used to identify individuals at risk for metabolic syndrome, insulin resistance and non-insulin dependent diabetes, and allows monitoring of the progression of those disease states, as well as progress made by therapeutic interventions.02-10-2011
20110040164Analyte Sensor Ports - The present disclosure provides a contamination resistant sensor port which includes one or more sealing members positioned so as to limit and/or prevent internal contamination of the sensor port with fluids and/or particles present in the environment outside the sensor port.02-17-2011
20090221890Diabetes Management System - In one embodiment, a diabetes management system comprises a glucose monitoring system, a pump system, and a remote device. The glucose monitoring system and pump system are attached to a patient and covered by a soft shell. The glucose monitoring system and the pump system are controlled by the small, touch-screen remote device such a patient can discreetly monitor blood glucose levels and administer insulin dosages. The remote device has a small and durable form factor that can be worn or carried in various ways.09-03-2009
20090082653ACCESS DISCONNECT DETECTION USING GLUCOSE - An access disconnect sensor for a patient undergoing extracorporeal blood processing includes an electrochemical fuel cell or sensor to detect blood leakage. The fuel cell includes circuitry for oxidizing glucose in the blood. The sensor also includes a transmitter to send a signal to a remote receiver that the sensor indicates the presence of blood. The circuitry may include a battery or may use electricity generated by the sensor to send a signal indicating a leak of blood or disconnection of the access needle.03-26-2009
20110124994Analyte Sensors Comprising Hydrogel Membranes - Generally, embodiments of the present disclosure relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have improved signal response and stability by inclusion of a coating including a hydrogel, a crosslinker, and a swelling modulator, where the coating is disposed proximate to a working electrode of in vivo and/or in vitro analyte sensors, e.g., continuous and/or automatic in vivo monitoring using analyte sensors and/or test strips. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.05-26-2011
20110124993Analyte Sensors Comprising Self-Polymerizing Hydrogels - Generally, embodiments of the present disclosure relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have improved uniformity of distribution of the sensing layer by inclusion of a self-polymerizing hydrogel, where the sensing layer is disposed proximate to a working electrode of in vivo and/or in vitro analyte sensors, e.g., continuous and/or automatic in vivo monitoring using analyte sensors and/or test strips. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.05-26-2011
20110137142Hermetic Implantable Sensor - At least one conductor is formed at a preselected location on a substrate made of a first insulating material having a high temperature resistance. The conductor is made from a solidified electrically conductive thick film material. A coating made of a second insulating material is formed over the substrate to hermetically seal at least a portion of the conductor. An exposed distal region of the conductor provides a detection electrode. The conductor has a reduced porosity that inhibits migration of fluid or constituents thereof through the conductor.06-09-2011
20090312619Analyte Monitoring Device And Methods Of Use - An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.12-17-2009
20100063373CALIBRATION TECHNIQUES FOR A CONTINUOUS ANALYTE SENSOR - Disclosed herein are systems and methods for calibrating a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes one or more electrodes to measure an additional analyte. Such measurements may provide a baseline or sensitivity measurement for use in calibrating the sensor. Furthermore, baseline and/or sensitivity measurements may be used to trigger events such as digital filtering of data or suspending display of data.03-11-2010
20090216102Analyte Monitoring Device and Methods of Use - An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.08-27-2009
20090216103TRANSCUTANEOUS ANALYTE SENSOR - The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.08-27-2009
20090216101Analyte Monitoring Device and Methods of Use - An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.08-27-2009
20090216100METHOD FOR TRANSMITTING DATA IN A BLOOD GLUCOSE SYSTEM AND CORRESPONDING BLOOD GLUCOSE SYSTEM - The present invention relates to a method for wireless transmission of data between components of a blood glucose system (08-27-2009
20110251471IMPLANTABLE POWER SOURCES AND SENSORS - A protein is provided, including a glucose binding site, cyan fluorescent protein (CFP), and yellow fluorescent protein (YFP). The protein is configured such that binding of glucose to the glucose binding site causes a reduction in a distance between the CFP and the YFP. Substance monitoring apparatus (10-13-2011
20110077491Analyte Monitoring Device and Methods of Use - An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.03-31-2011
20110066019Biosensor Membranes Composed Of Polymers Containing Heterocyclic Nitrogens - Novel membranes comprising various polymers containing heterocyclic nitrogen groups are described. These membranes are usefully employed in electrochemical sensors, such as amperometric biosensors. More particularly, these membranes effectively regulate a flux of analyte to a measurement electrode in an electrochemical sensor, thereby improving the functioning of the electrochemical sensor over a significant range of analyte concentrations. Electrochemical sensors equipped with such membranes are also described.03-17-2011
20100331645METHODS AND SYSTEMS FOR WIRELESS COMMUNICATION BETWEEN A BLOOD GLUCOSE METER AND A PORTABLE COMMUNICATION DEVICE - A blood glucose measuring system which comprises a blood glucose (bG) meter and a portable communication device (PCD) and methods thereof are disclosed. The blood glucose meter comprises a measurement module and a wireless module, wherein the measurement module is operable to measure the blood glucose level of a blood sample, the wireless module is an embeddable module and communicates to the measurement module via a serial interface, and the wireless module is operable to wirelessly communicate to the portable communication device. The portable communication device is operable to wirelessly receive information from the blood glucose meter related to the blood glucose measurement.12-30-2010
20110257495Analyte Monitoring Device and Methods - Method and system for determining real time analyte concentration including an analyte sensor having a portion in fluid contact with an interstitial fluid under a skin layer, an on-body electronics including a housing coupled to the analyte sensor and configured for positioning on the skin layer, the on-body electronics housing including a plurality of electrical contacts , on the housing; and a data analysis unit having a data analysis unit housing and a plurality of probes , on the housing. Each of the probes configured to electrically couple to a respective electrical contact when the data analysis unit is positioned in physical contact with the on-body electronics. The one or more signals on the probes correspond to one or more of a substantially real time monitored analyte concentration level (MACL), MACL over a predetermined time period, or a rate of change of the MACL, or combinations thereof, are provided.10-20-2011
20090005664Blood Testing Apparatus Having a Rotatable Cartridge with Multiple Lancing Elements and Testing Means - A blood testing apparatus has a test member and a laser source configured to produce a wound from which blood flows. The laser source produces at least a cutting wavelength, and a coagulation wavelength. Electronics for analysis and a display are provided. The test member, laser source, electronics and display form a glucose monitoring system that is integrated in a single apparatus.01-01-2009
20100004521IMPLANTABLE VOLTAIC CELL - The invention provides a voltaic cell for implantation into the body of a subject that oxidizes oxidizable biological material to generate current to do work. The voltaic cell comprises a biologically inert shell having an inner compartment containing a cathodic environment and an anodic environment on the outer surface of the shell that is in contact with bodily fluid. A connector connects the anodic environment to the cathodic environment and has a component that provides resistance between the anodic and cathodic environments. The shell contains at least one salt bridge disposed within the shell that permits passage of small ions between the inner compartment and the bodily fluid, thereby completing the circuit. The invention also provides devices such as a glucometer which continuously detects glucose and transmits a signal to an external device which provides an output, such as blood glucose level. Methods of using the same are also provided.01-07-2010
20090247855POLYMER MEMBRANES FOR CONTINUOUS ANALYTE SENSORS - Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the device has a sensing mechanism and a sensing membrane that includes at least one surface-active group-containing polymer and that is located over the sensing mechanism. The sensing membrane may have a bioprotective layer configured to substantially block the effect and/or influence of non-constant noise-causing species.10-01-2009
20080242962System for in-vitro measurement of an analyte concentration - The analyte concentration, such as glucose, in a human or animal body is measured with an implantable sensor that generates measurement signals. The measurement signals are compressed through statistical techniques to produced compressed measurement data that can is easier to process and communicate. A base station carries the implantable sensor along with a signal processor, memory, and a transmitter. A display device is also disclosed that can receive the compressed measurement data from the base station for further processing and display.10-02-2008
20080319291Blood Testing Apparatus Having a Rotatable Cartridge with Multiple Lancing Elements and Testing Means - A blood testing apparatus includes a device for withdrawing blood, a membrane-type testing element, an evaluating device, and a display device forming a complete system which can be manipulated as a single piece of apparatus. Multiple testing elements can be inserted into the apparatus and brought successively to a work position for carrying out several measurements. The blood withdrawing device includes multiple pricking elements. One pricking element is pushed through one testing element and pricks the surface of the skin of a user. The pricking position is disposed so that blood withdrawn from the surface of the skin can impinge upon a testing element.12-25-2008
20080214917Method and apparatus for analyte measurement test time - A method is provided for analyte measurement by a user using an analyte measurement device. An analyte measurement is provided with a plurality of penetrating members and analyte sensors. Each analyte sensor is positioned in a sample chamber with a volume no greater than 1 μl. Each sample chamber has a working electrode, reference electrode and a counter electrode. The working electrode has a conductor, an enzyme and a mediator. A penetrating member and an unused analyte detecting member are presented into an active position. The following steps are then performed: (a) the penetrating member is fired to prick the skin and bring a fluid sample to the analyte detecting member, (b) the analyte level is measured, and (c) it takes no more than 10 seconds from the step of presenting the penetrating members and unused analyte into the active position through the step of measuring the analyte level.09-04-2008
20080255437METHOD AND APPARATUS FOR PROVIDING DATA PROCESSING AND CONTROL IN MEDICAL COMMUNICATION SYSTEM - Methods and apparatus for providing data processing and control for use in a medical communication system are provided.10-16-2008
20080249385ISOLATED INTRAVENOUS ANALYTE MONITORING SYSTEM - A continuous intravenous analyte monitoring system includes an amperometric biosensor detecting an analyte concentration in the blood, a controller receiving a signal from the biosensor and computing the concentration, and an isolation device isolating the biosensor from EMI. A CPU may be coupled to the controller via the isolation device for continuous output of sensed concentration to a display unit. Isolated circuits may include a temperature sensor transmitting biosensor temperature to the controller for correction of the computed concentration, a multiplexer combining biosensor and temperature sensor signals, and an A/D converter converting multiplexed input to the controller. The biosensor may be a multi-electrode sensor having a working electrode immobilizing an glucose oxidase enzyme to detect blood glucose concentration. The biosensor and temperature sensor may be located in vivo using a catheter for continuous monitoring.10-09-2008
20110015508Analyte Monitoring and Management System and Methods Therefor - Method and apparatus for providing multiple data receiver units in a data monitoring and management system such as analyte monitoring system where a first data receiver includes all of the functionalities for the data monitoring and management system receiver unit, and a second data receiver unit is configured with a limited functions to provide application specific convenience to the user or patient is disclosed.01-20-2011
20110054282Analyte Monitoring System and Methods for Managing Power and Noise - Disclosed herein are methods and systems for conserving energy of a power source of an analyte monitoring device. Also disclosed herein are methods and systems for reducing noise during data transmissions to and from the analyte monitoring device.03-03-2011
20110021896Biosensor Membranes Composed of Polymers Containing Heterocyclic Nitrogens - Novel membranes comprising various polymers containing heterocyclic nitrogen groups are described. These membranes are usefully employed in electrochemical sensors, such as amperometric biosensors. More particularly, these membranes effectively regulate a flux of analyte to a measurement electrode in an electrochemical sensor, thereby improving the functioning of the electrochemical sensor over a significant range of analyte concentrations. Electrochemical sensors equipped with such membranes are also described.01-27-2011
20110263956DEVICE FOR NON-INVASIVELY MEASURING GLUCOSE - In order to increase the accuracy of non-invasive glucose measurement, the device uses a combination of three non-invasive methods: ultrasonic, electromagnetic and thermal. The non-invasive glucose monitor comprises a Main Unit, which drives three different sensor channels (one per technology), located on an external unit configured as an ear clip attached to the subject's ear lobe. To effect the ultrasonic channel, ultrasonic piezo elements are positioned on opposing portions of the ear clip and thus opposite sides of the ear lobe. For implementation of the electromagnetic channel, capacitor plates are positioned on opposing portions of the ear clip and the ear lobe serves as the dielectric. The thermal channel includes a heater and a sensor positioned on the ear clip in close juxtaposition to the ear lobe.10-27-2011
20110071377CIRCUIT BOARD FOR BODY FLUID COLLECTION, METHOD FOR PRODUCING THE SAME, METHOD FOR USING THE SAME, AND BIOSENSOR INCLUDING THE CIRCUIT BOARD FOR BODY FLUID COLLECTION - A circuit board for body fluid collection includes a belt-like supporting substrate, and a plurality of measurement units defined in the supporting substrate along the longitudinal direction of the supporting substrate. The measurement units each include a puncture needle formed from the supporting substrate along the longitudinal direction of the supporting substrate by forming an opening in the supporting substrate, an insulating base layer formed on the supporting substrate, and a conductive layer formed on the insulating base layer and including an electrode for making contact with a body fluid collected by puncturing with the puncture needle.03-24-2011
20100292554Analyte Monitoring Device and Methods of Use - An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.11-18-2010
20100292552Analyte Monitoring Device and Methods of Use - An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.11-18-2010
20100324396Analyte Monitoring Device and Methods of Use - An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.12-23-2010
20110257496MEASUREMENT DEVICE, INSULIN INFUSION DEVICE, MEASUREMENT METHOD, METHOD FOR CONTROLLING INSULIN INFUSION DEVICE, AND PROGRAM - Provided are a measurement device by which the blood-sugar level or the like associated with the living activity of a diabetic patient can be measured easily and precisely and the measured valued associated with the living activity can be clinically applied easily, and an insulin infusion device, a measurement method, a method for controlling an insulin fusion device, and a program. A blood-sugar level measurement device (10-20-2011
20100179404TRANSCUTANEOUS ANALYTE SENSOR - The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.07-15-2010
20110137143SENSOR WITH FINE NEEDLE HAVING CHANNEL FORMED THEREIN - This sensor with a fine needle having a channel formed therein includes a fine needle portion of resin provided with a channel for sucking body fluid, a liquid sump portion, connected with the channel, pooling the body fluid, a sensor portion for detecting a specific component contained in the body fluid pooled in the liquid sump portion, a cover portion, in which the sensor portion is arranged, arranged to cover the liquid sump portion and an air hole connected with the channel formed in the fine needle portion through the liquid sump portion.06-09-2011
20110190614TRANSCUTANEOUS ANALYTE SENSOR - The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.08-04-2011
20110152654ANALYTE SENSORS COMPRISING BLENDED MEMBRANE COMPOSITIONS AND METHODS FOR MAKING AND USING THEM - Embodiments of the invention provide analyte sensors having elements designed to modulate their chemical reactions as well as methods for making and using such sensors. In certain embodiments of the invention, the sensor includes an analyte modulating membrane that comprises a blended mixture of a linear polyurethane/polyurea polymer, and a branched acrylate polymer.06-23-2011
20100030051Subcutaneous Glucose Electrode - A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode is designed to allow “one-point” in vivo calibration, i.e., to have zero output current at zero glucose concentration, even in the presence of other electroreactive species of serum or blood. The electrode is preferably three or four-layered, with the layers serially deposited within a recess upon the tip of a polyamide insulated gold wire. A first glucose concentration-to-current transducing layer is overcoated with an electrically insulating and glucose flux limiting layer (second layer) on which, optionally, an immobilized interference-eliminating horseradish peroxidase based film is deposited (third layer). An outer (fourth) layer is biocompatible.02-04-2010
20100030045ANALYTE SENSOR APPARATUSES COMPRISING MULTIPLE IMPLANTABLE SENSOR ELEMENTS AND METHODS FOR MAKING AND USING THEM - Embodiments of the invention provide analyte sensors having optimized elements and/or configurations of elements as well as methods for making and using such sensors. Typical embodiments of the invention include glucose sensors used in the management of diabetes.02-04-2010
20100030049Subcutaneous Glucose Electrode - A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode is designed to allow “one-point” in vivo calibration, i.e., to have zero output current at zero glucose concentration, even in the presence of other electroreactive species of serum or blood. The electrode is preferably three or four-layered, with the layers serially deposited within a recess upon the tip of a polyamide insulated gold wire. A first glucose concentration-to-current transducing layer is overcoated with an electrically insulating and glucose flux limiting layer (second layer) on which, optionally, an immobilized interference-eliminating horseradish peroxidase based film is deposited (third layer). An outer (fourth) layer is biocompatible.02-04-2010
20100030047Subcutaneous Glucose Electrode - A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode is designed to allow “one-point” in vivo calibration, i.e., to have zero output current at zero glucose concentration, even in the presence of other electroreactive species of serum or blood. The electrode is preferably three or four-layered, with the layers serially deposited within a recess upon the tip of a polyamide insulated gold wire. A first glucose concentration-to-current transducing layer is overcoated with an electrically insulating and glucose flux limiting layer (second layer) on which, optionally, an immobilized interference-eliminating horseradish peroxidase based film is deposited (third layer). An outer (fourth) layer is biocompatible.02-04-2010
20100030046Subcutaneous Glucose Electrode - A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode is designed to allow “one-point” in vivo calibration, i.e., to have zero output current at zero glucose concentration, even in the presence of other electroreactive species of serum or blood. The electrode is preferably three or four-layered, with the layers serially deposited within a recess upon the tip of a polyamide insulated gold wire. A first glucose concentration-to-current transducing layer is overcoated with an electrically insulating and glucose flux limiting layer (second layer) on which, optionally, an immobilized interference-eliminating horseradish peroxidase based film is deposited (third layer). An outer (fourth) layer is biocompatible.02-04-2010
20100016698INTEGRATED RECEIVER FOR CONTINUOUS ANALYTE SENSOR - A system is provided for monitoring glucose in a host, including a continuous glucose sensor that produces a data stream indicative of a host's glucose concentration and an integrated receiver that receives the data stream from the continuous glucose sensor and calibrates the data stream using a single point glucose monitor that is integral with the integrated receiver. The integrated receiver obtains a glucose value from the single point glucose monitor, calibrates the sensor data stream received from the continuous glucose sensor, and displays one or both of the single point glucose measurement values and the calibrated continuous glucose sensor values on the user interface.01-21-2010
20110144465LOW OXYGEN IN VIVO ANALYTE SENSOR - The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous and subcutaneous measurement of glucose in a host.06-16-2011
20080208024Method of measuring skin conductance, method of analyzing component concentration, skin conductance measuring apparatus, and component concentration analyzer - The present invention provides a method of measuring skin conductance which can obtain an accuracy measurement result, comprising the steps of: supplying a low conductivity medium as a medium for holding tissue fluid that contains a predetermined component of a subject to a medium containing part; disposing the medium containing part on an extraction region of a skin of the subject; extracting tissue fluid through the extraction region into the low conductivity medium within the medium containing part; supplying electric power between a first electrode for supplying electric power to the extraction region and a second electrode for supplying electric power to the skin outside the extraction region; and measuring the conductance of the extraction region based on the electric power supplied between the first electrode and second electrode. A method of analyzing a component concentration, a skin conductance measuring apparatus, and a component concentration analyzer are also disclosed.08-28-2008
20110112389Analyte Monitoring Device and Methods of Use - An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.05-12-2011
20090137888SYSTEM FOR MONITORING OF PATIENTS - A patient monitoring system implemented by a service provider for users via recording a patient's analytes measurements by non-invasively interrogating a skin patch placed upon the patient's skin surface. The system includes an input module to provide a device to measure analytes from a patient, such as a measurement of the blood glucose level. The measurement is shared among a plurality of output devices such as computers, personal digital assistants (PDAs), cellular phones, and pagers that are stationed or held by various users, such as doctors, patients, researchers, pharmacies, labs, and health insurers. In addition, behavioral attributes are recorded and correlated with the analytes measurements to generate a profile. The profile is selectively sent to output devices based on the user profile corresponding to the output device. Also, access to the profile is monitored by a security module that encrypts the profile to prevent access by un-authorized users. 05-28-2009
20120046533COMBINED SENSOR AND INFUSION SETS - Embodiments of the invention provide a dual insertion set for supplying a fluid to the body of a patient and for monitoring a body characteristic of the patient. Typical embodiments of the invention include a base, an infusion portion coupled to a first piercing member and a sensor portion coupled to a second piercing member. The infusion portion includes a cannula coupled to the piercing member for supplying a fluid to a placement site. The sensor portion includes a sensor coupled to and extending from the base having at least one sensor electrode formed on a substrate and is coupled to the piercing member in a manner that allows the sensor to be inserted at the placement site. The base is arranged to secure the dual insertion set to the skin of a patient. Typically the infusion portion and sensor portion piercing members are arranged such that when they are operatively coupled to the base, they are disposed in a spatial orientation designed to inhibit sensor interference that may be caused by compounds present in fluids infused through the cannula.02-23-2012
20120046534ANALYTE SENSING BIOINTERFACE - Disclosed herein is an analyte sensing biointerface that comprises a sensing electrode incorporated within a non-conductive matrix comprising a plurality of passageways extending through the matrix to the sensing electrode. Also disclosed herein are methods of manufacturing a sensing biointerface and methods of detecting an analyte within tissue of a host using an analyte sensing biointerface.02-23-2012
20120004524PROTRUDENT ANALYTE SENSOR - The methods and apparatus for detecting an analyte in blood are useful for detecting an analyte in tissue of a subject. The apparatus comprises a sensor, which comprises an elongated conductive material having a protrudent end, the protrudent end comprising an electrode that detects the presence of an analyte; a substrate affixed to the conductive material; and a support having an external surface, a proximal end, and a distal end. The conductive material is positioned on the support and the protrudent end of the conductive material protrudes beyond the distal end of the support. Optionally, the sensor is suspended within the lumen of a venous flow device. Typically, only a portion of the sensor is suspended within the lumen of the venous flow device, said portion comprising the protrudent end of the conductive material. Alternatively, the conductive material is positioned on the external surface of the intravenous infusion catheter.01-05-2012
20120310063REAL-TIME SELF-CALIBRATING SENSOR SYSTEM AND METHOD - A system and method for calibrating a sensor of a characteristic monitoring system in real time utilizes a self-calibration module for periodic determination of, and compensation for, the IR drop across unwanted resistances in a cell. A current-interrupt switch is used to open the self-calibration module circuit and either measure the IR drop using a high-frequency (MHz) ADC module, or estimate it through linear regression of acquired samples of the voltage across the sensor's working and reference electrodes (Vmeasured) over time. The IR drop is then subtracted from the closed-circuit value of Vmeasured to calculate the overpotential that exists in the cell (Vimportant). Vimportant may be further optimized by subtracting the value of the open-circuit voltage (Voc) across the sensor's working and reference electrodes. The values of Vmeasured and Vimportant are then controlled by respective first and second control units to compensate for the IR drop.12-06-2012
20120022352BLOOD SENSOR, BLOOD TESTING APPARATUS, AND METHOD FOR CONTROLLING BLOOD TESTING APPARATUS - A blood sensor includes a base (01-26-2012
20100280347BIOSENSORS AND METHODS FOR MAKING AND USING THEM - Embodiments of the invention provide analyte sensors having optimized permselective membranes and methods for making and using such sensors. Embodiments of the invention also provide analyte sensors such as those having porous matrices coated with an analyte sensing composition and methods for making and using such sensors. Illustrative embodiments include electrochemical glucose sensors having glucose oxidase coatings.11-04-2010
20120209098SYSTEM AND METHODS FOR PROCESSING ANALYTE SENSOR DATA - Systems and methods for processing sensor analyte data, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. During initial calibration, the analyte sensor data is evaluated over a period of time to determine stability of the sensor. The sensor may be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. The calibration may be updated after evaluating the calibration set for best calibration based on inclusion criteria with newly received reference analyte data. Fail-safe mechanisms are provided based on clinical acceptability of reference and analyte data and quality of sensor calibration. Algorithms provide for optimized prospective and retrospective analysis of estimated blood analyte data from an analyte sensor.08-16-2012
20100210933BLOOD GLUCOSE MEASUREMENT DEVICE - A blood glucose measuring system comprising: a computer mouse that transmits data to an associated computer; a LED display residing on the computer mouse; a blood glucose strip receiver residing on the computer mouse; a blood glucose measurement mechanism; and software residing on the associated computer which receives blood glucose data, where the software stores the data onto a database within the associated computer. In one exemplary embodiment, the mouse may include two actuation pads and Bluetooth technology to transmit data from the mouse to the associated computer. The LED display provided on the mouse displays the glucose results measured by the measurement means. The software residing on the associated computer tabulates the blood glucose measurements and stores the data in a predetermined format.08-19-2010
20100121166Subcutaneous Glucose Electrode - A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode is designed to allow “one-point” in vivo calibration, i.e., to have zero output current at zero glucose concentration, even in the presence of other electroreactive species of serum or blood. The electrode is preferably three or four-layered, with the layers serially deposited within a recess upon the tip of a polyamide insulated gold wire. A first glucose concentration-to-current transducing layer is overcoated with an electrically insulating and glucose flux limiting layer (second layer) on which, optionally, an immobilized interference-eliminating horseradish peroxidase based film is deposited (third layer). An outer (fourth) layer is biocompatible.05-13-2010
20120165636Systems and Methods for Improved In Vivo Analyte Sensor Function - Embodiments of the present disclosure relate to systems for improving the performance of one or more components of a sensor, such as an in vivo analyte sensor, including, for example, continuous and/or automatic in vivo analyte sensors, by detecting inflammation at an insertion site and adjusting the signal of the sensor, adjusting the display of the signal (e.g., inactivation of display), or indicating administration of an anti-inflammatory agent, such as an interleukin 1 receptor antagonist. Embodiments of the present disclosure also relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have improved signal response and stability by inclusion of one or more of a clot activator and/or an immunosuppressant proximate to a working electrode of an in vivo analyte sensor. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.06-28-2012
20120165635COMPENSATING FOR TEMPERATURE DRIFTS DURING GLUCOSE SENSING - Temperature variations in a patient's body can lead to inaccurate glucose readings. To compensate for changes in temperature, the temperature at a glucose sensing site can be sensed using a thermocouple. A compensated glucose level can be determined based on the temperature and the sensed glucose level. A glucose sensing device is described that includes a glucose sensor having a working electrode and a thermocouple having a junction positioned proximate the working electrode, with both the glucose and temperature sensors including the same metals.06-28-2012
20120130214ANALYTE SENSOR - The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.05-24-2012
20120130213ELECTROCHEMICAL SENSOR - An electrochemical sensor includes a base plate including one end portion and another end portion, an electrode portion formed on the one end portion of the base plate, a connecting portion, formed on the another end portion of the base plate, for electrically connecting the electrode portion to a monitoring instrument, and an attaching portion formed on the another end portion, the attached portion being employed for attaching the another end portion to the monitoring instrument in a state where the one end portion is enabled to swing relatively to the monitoring instrument.05-24-2012
20120316412Analyte Monitoring Device and Methods of Use - An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.12-13-2012
20120215083MEASURING APPARATUS AND MEASUREMENT METHOD - Disclosed is a measuring device for obtaining numerical information concerning a substance present in the interstitial subcutaneous fluid, the device being equipped with a sensor unit that outputs signals in accordance with the numerical information concerning the substance and an arithmetic unit (control unit) that receives the signals outputted from the sensor unit and arithmetically processes the signals. The sensor unit is equipped with a sensor, some of which is punctured into the skin. The arithmetic unit (control unit) has been disposed so as to be separate from the sensor unit.08-23-2012
20100204555DEVICE AND METHOD FOR DETERMINING ANALYTE LEVELS - Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices, that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices comprise a unique microarchitectural arrangement in the sensor region that allows accurate data to be obtained over long periods of time.08-12-2010
20120136229STRAIN MONITORING SYSTEM AND APPARATUS - A system for monitoring strain as an indicator of biological conditions, such as spinal fusion, glucose levels, spinal loading, and heart rate. The system includes an inter-digitated capacitor sensor, and RF transmitter, and an associated antenna, all of which are microminiature or microscopic in size and can be implanted in a biological host such as a human or animal. An inductively coupled power supply is also employed to avoid the need for implantation of chemical batteries. Power is provided to the sensor and transmitter, and data is transmitted from the sensor, when an external receiving device, such as a handheld RF ID type receiver, is placed proximate the location of the implanted sensor, transmitter and inductively coupled power supply. The implanted sensor, transmitter and inductively coupled power supply can be left in place permanently or removed when desired.05-31-2012
20120215084METHODS AND APPARATUS FOR SAMPLING AND ANALYZING BODY FLUID - A sampling device for sampling body fluid includes a lancet for making an incision, a capillary tube for drawing-up body fluid from the incision, and a test strip affixed to an upper end of the capillary tube for receiving the fluid. An absorbent pad can be disposed between the test strip and capillary tube for spreading-out the fluid being transferred to the test strip. An on-site analyzer such as an optical analyzer and/or an electrochemical analyzer can be mounted in the device for analyzing the fluid. Alternatively, a test strip can be slid through a slot formed in the bottom end of the device so that by passing the device against the skin after an incision has been formed, the test strip will directly contact body fluid emanating from the incision.08-23-2012
20100198031METHOD AND APPARATUS FOR BACKGROUND CURRENT ARRANGEMENTS FOR A BIOSENSOR - Embodiments of the present invention provide for raising a background current setting for a biosensor above the actual (measured) background current present (i.e., overestimating the background current), particularly in the hypoglycemic range, to improve sensor accuracy and decrease the chance of glucose value overestimation by the sensor.08-05-2010
20110184265Method and Apparatus for Providing Notification in Analyte Monitoring Systems - An analyte monitoring system for determining an analyte concentration of a biofluid upon user command and adapted to determine rate of change of the analyte concentration in addition to the real time analyte concentration and to output an alarm notification upon an anticipated physiological condition determined by projected analyte levels is provided. Methods, devices and kits are also provided.07-28-2011
20110184264Universal Test Strip Port - The present disclosure provides a sensor port configured to receive a plurality of analyte sensors having different sizes, shapes and/or electrode configurations. Also provided are analyte meters, analyte monitoring devices and/or systems and drug delivery devices and/or systems utilizing the disclosed sensor ports.07-28-2011
20100174166TRANSCUTANEOUS ANALYTE SENSOR - The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.07-08-2010
20100174165TRANSCUTANEOUS ANALYTE SENSOR - The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.07-08-2010
20100174164TRANSCUTANEOUS ANALYTE SENSOR - The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.07-08-2010
20120172691TRANSCUTANEOUS ANALYTE SENSOR - The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.07-05-2012
20120172690IMPLANTABLE MEDICAL DEVICE FIXATION - An assembly includes an implantable medical device (IMD) including a conductive housing, and a fixation element assembly attached to the IMD. The fixation element assembly includes a set of active fixation tines and an insulator to electrically isolate the set of active fixation tines from the conductive housing of the implantable medical device. The active fixation tines in the set are deployable from a spring-loaded position in which distal ends of the active fixation tines point away from the implantable medical device to a hooked position in which the active fixation tines bend back towards the implantable medical device. The active fixation tines are configured to secure the implantable medical device to a patient tissue when deployed while the distal ends of the active fixation tines are positioned adjacent to the patient tissue.07-05-2012
20100298681Analyte Monitoring Device and Methods of Use - An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.11-25-2010
20100298682Analyte Monitoring Device and Methods of Use - An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.11-25-2010
20100274111Analyte Monitoring Device and Methods of Use - An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.10-28-2010
20100292551Devices, systems, methods and tools for continuous glucose monitoring - One aspect of the invention provides a glucose monitor having a plurality of tissue piercing elements, each tissue piercing element having a distal opening, a proximal opening and interior space extending between the distal and proximal openings; a sensing area in fluid communication with the proximal openings of the tissue piercing elements; sensing fluid extending from the sensing area into substantially the entire interior space of the tissue piercing elements; and a glucose sensor adapted to detect a concentration of glucose in the sensing fluid within the sensing area. Another aspect of the invention provides a method of in vivo monitoring of an individual's interstitial fluid glucose concentration including the following steps: inserting distal ends of a plurality of tissue piercing elements through a stratum corneum area of the individual's skin, the tissue piercing elements each having a distal opening, a proximal opening, an interior space extending between the distal and proximal openings, and a sensing fluid filling substantially the entire interior space; and sensing a glucose concentration of the sensing fluid.11-18-2010
20090018424ANALYTE SENSOR - Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory system.01-15-2009
20110004084Method of Calibrating an Analyte-Measurement Device, and Associated Methods, Devices and Systems - The invention relates to a method for calibrating an analyte-measurement device that is used to evaluate a concentration of analyte in bodily fluid at or from a measurement site in a body. The method involves measuring a concentration, or calibration concentration, of an analyte in blood from an “off-finger” calibration site, and calibrating the analyte-measurement device based on that calibration concentration. The invention also relates to a device, system, or kit for measuring a concentration of an analyte in a body, which employs a calibration device for adjusting analyte concentration measured in bodily fluid based on an analyte concentration measured in blood from an “off-finger” calibration site.01-06-2011
20120265042METHOD AND APPARATUS FOR INSERTION OF A SENSOR - A device and method for delivering a device such as a sensor or fluid transport structure or a fluid transport structure sensor combination into, for example, mammalian skin. Such a device allows a sensor to penetrate mammalian skin without the use of an introducer device such as a needle. A device in accordance with embodiments of the present disclosure includes a housing for attachment to mammalian skin including an exit port for receiving the distal end of a biosensor and an injection activation device including a mechanism for forcing the sensing device from a first position within the housing, through the exit port to a second position, with sufficiently high velocity to partially penetrate the mammalian skin.10-18-2012
20110046467DUAL ELECTRODE SYSTEM FOR A CONTINUOUS ANALYTE SENSOR - Disclosed herein are systems and methods for a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes first and second working electrodes to measure analyte or non-analyte related signal, both of which electrode include an interference domain.02-24-2011
20100228110IMPLANTABLE BIOSENSOR WITH AUTOMATIC CALIBRATION - Implantable self-calibrating biosensor Subcutaneously or intracorporeally implantable biosensor, characterized by a closed microfluidic circuit with calibrating fluids, which communicates by a backward micro-dialysis logic with the exterior of said circuit, an open and in contact with the tissues and the interstitial fluid working electrode, for its self-calibration. One or more working electrodes may be positioned inside openable boxes from EAP, and be opened for the duration of the measurement and closed immediately after, succeeding one another in the measurement, as their sensitivity is diminished.09-09-2010
20100234707SYSTEMS AND METHODS FOR REPLACING SIGNAL ARTIFACTS IN A GLUCOSE SENSOR DATA STREAM - Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as ischemia, pH changes, temperatures changes, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system replaces some or the entire data stream continually or intermittently including signal estimation methods that particularly address transient signal artifacts. The system is also capable of detecting the severity of the signal artifacts and selectively applying one or more signal estimation algorithm factors responsive to the severity of the signal artifacts, which includes selectively applying distinct sets of parameters to a signal estimation algorithm or selectively applying distinct signal estimation algorithms.09-16-2010
20120277562TRANSCUTANEOUS ANALYTE SENSOR - The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.11-01-2012
20110270062SYSTEMS AND METHODS FOR REPLACING SIGNAL ARTIFACTS IN A GLUCOSE SENSOR DATA STREAM - Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as ischemia, pH changes, temperatures changes, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system replaces some or the entire data stream continually or intermittently including signal estimation methods that particularly address transient signal artifacts. The system is also capable of detecting the severity of the signal artifacts and selectively applying one or more signal estimation algorithm factors responsive to the severity of the signal artifacts, which includes selectively applying distinct sets of parameters to a signal estimation algorithm or selectively applying distinct signal estimation algorithms.11-03-2011
20120330120Analyte Monitoring: Stabilizer for Subcutaneous Glucose Sensor with Incorporated Antiglycolytic Agent - An analyte sensor including an antiglycolytic agent or a precursor thereof and a chelating agent that stabilizes the antiglycolytic agent positioned proximate to the working electrode of the sensor. Also provided are systems and methods of using the electrochemical analyte sensors in analyte monitoring.12-27-2012
20120330119Analyte Testing Device with Lancet Cartridge and Test Strip Cartridge - An analyte testing device housing a lancet cartridge and a test strip cartridge is described. The testing device simplifies analyte testing/monitoring by providing an actuator and linkage mechanism that: (i) cocks a lancing device, (ii) exposes a test strip for use; and (iii) advances the lancet cartridge. The testing device also includes conversion electronics, which receives a signal from a test trip and converts the signal into readable data.12-27-2012
20120101352Analyte Monitoring and Management System and Methods Therefor - Method and apparatus for providing multiple data receiver units in a data monitoring and management system such as analyte monitoring system where a first data receiver includes all of the functionalities for the data monitoring and management system receiver unit, and a second data receiver unit is configured with a limited functions to provide application specific convenience to the user or patient is disclosed.04-26-2012
20120101351WIDE BAND FIELD RESPONSE MEASUREMENT FOR GLUCOSE DETERMINATION - A method and device for determining the glucose level in living tissue are based on measuring the response of the tissue an electric field as well as temperature measurements. In order to improve accuracy, it has been found that measurements in at least three frequency ranges between 1 kHz and 200 kHz, 0.2 MHz an 100 MHz as well as above 1 GHz should be combined since the response of the tissue in these different frequency ranges is ruled by differing mechanisms.04-26-2012
20100191083ENGINEERED CONDUCTIVE POLYMER FILMS TO MEDIATE BIOCHEMICAL INTERACTIONS - The conductive polymer films of this disclosure reversibly and selectively mediate ligand-receptor interactions. This electrochemical manipulation of biochemical interactions is accomplished by embedding or adsorbing receptors for ligands of interest in or onto a conductive polymer matrix. The matrix can also be doped, for example, with desired ions, polyions, or surfactants. Depending on the receptor properties and dopants utilized, ligand-receptor interactions at the polymer-electrolyte interface are manipulated by controlling the oxidation and reduction of the conductive polymer. The intrinsic charge transfer characteristics of conductive polymers are used to modulate ligand-receptor interactions.07-29-2010
20100185070DUAL ELECTRODE SYSTEM FOR A CONTINUOUS ANALYTE SENSOR - Disclosed herein are systems and methods for a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes first and second working electrodes to measure additional analyte or non-analyte related signal. Such measurements may provide a background and/or sensitivity measurement(s) for use in processing sensor data and may be used to trigger events such as digital filtering of data or suspending display of data.07-22-2010
20120150006STIMULI RESPONSIVE MEMBRANE - There is provided a glucose responsive membrane comprising a nanoporous support substrate and a coating of a glucose responsive hydrogel attached to a surface of the nanoporous substrate. There are also provided methods for the preparation of the glucose responsive membrane and a medical device for the monitoring or regulation of glucose levels in a patient comprising the membrane.06-14-2012
20120150005Analyte Sensors with a Sensing Surface Having Small Sensing Spots - Embodiments of the present disclosure relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have a sensing surface that includes two or more sensing elements disposed laterally to each other, where the sensing surface is on a working electrode of in vivo and/or in vitro analyte sensors, e.g., continuous and/or automatic in vivo monitoring using analyte sensors and/or test strips. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.06-14-2012
20120150004Transdermal Sampling and Analysis Device - Transdermal sampling and analysis device, method and system are provided for non-invasively and transdermally obtaining biological samples from a subject and determining levels of analytes of the obtained biological samples. The transdermal sampling and analysis device, method and system may cause disruption to the skin cells to create capillary-like channels from which biological samples may flow to the transdermal sampling and analysis device. The transdermal sampling and analysis device, method and system may collect the biological samples in a reservoir where the biological sample may chemically react with a biologically reactive element. A sensor may convert the produced electrons (ions) into measured electrical signals. The converted signals may be measured and the levels of an analyte may be determined based on the measured signals.06-14-2012
20080228054ANALYTE MEASURING DEVICE - An implantable analyte-measuring device including a membrane adapted to promote vascularization and/or interfere with barrier cell layer formation. The membrane includes any combination of materials, architecture, and bioactive agents that facilitate analyte transport to provide long-term in vivo performance of the implantable analyte-measuring device.09-18-2008
20130172705ENZYME CO-FACTOR ENHANCEMENT OF BIOSENSOR PERFORMANCE - The present invention is broadly concerned with the crafting and manufacturability of an implantable enzymatic-based sensor characterized by a small size, optimum geometry, linearity of response over the concentration range of interest, extended shelf-life, selectivity for the analyte in question, and the ability to exclude bioactive interferents. More particularly, it is preferably concerned with a general approach to optimize the performance of the biorecognition elements required to produce biosensors of the type designed to provide, and in conjunction with a suitable signal processing unit, a current which is proportional to the concentration of the analyte of interest. The biosensors described herein may be implanted in vivo, including intra-cerebral, sub-cutaneous, intra-muscular, inter-peritoneal oral, serum, and vascular implantation, the majority of which may act as a surrogate for systemic monitoring and used to monitor analytes of interest in real-time. Multiple biosensors can be joined together to allow for the simultaneous recording of multiple analytes of interest. In addition to the in vivo applications, sensors of the design described herein may also find use in medical monitoring, industrial processes, fermentation, environmental monitoring, and waste water stream monitoring. The present invention offers co-factor enhancement of the biorecognition element, providing access to a range of biorecognition elements heretofore difficult to incorporate into a manufacturing process for the large-scale production of biosensors.07-04-2013
20130172704Integrated Needle and Test Strip with Aspiration Apparatus and Method of Use - Methods and systems to collect a sample of bodily fluid from a patient using an integrated needle and test strip assembly are provided. In this novel assembly, the test strip and needle form one unit that captures the sample of blood or interstitial fluid from the patient once the apparatus is pressed to the skin. The hollow aspiration needle includes more than one opening at a distal end, each opening coming into contact with the bodily fluid when disposed within a cutaneous or subcutaneous layer of the patient's skin. The disclosed test strip includes at least one reaction site for testing analyte concentrations and a means for linking to many commercially available test strip meters to provide readout of the analyte concentration. The sample may be captured by capillary flow, by an integrated aspirator, or by a differential vacuum device resident on the test strip meter.07-04-2013
20130178726STABILIZED POLYMERS FOR USE WITH ANALYTE SENSORS AND METHODS FOR MAKING AND USING THEM - Embodiments of the invention provide analyte sensors having elements designed to modulate their chemical reactions as well as methods for making and using such sensors. In certain embodiments of the invention, the sensor includes an analyte modulating membrane that comprises a linear polyurethane/polyurea polymer comprising one or more agents selected for their ability to stabilize the polymers against thermal and/or oxidative degradation.07-11-2013
20080214916Fluid Delivery With In Vivo Electrochemical Analyte Sensing - One or more therapeutic fluids, such as for example insulin can be delivered to a body. In addition or alternatively, the concentrations of one or more analytes can be measured in vivo. A feedback process can be used to regulate levels of the one or more analytes based on the measurements via delivery of the one or more therapeutic fluids. Related systems, apparatus, methods, and/or articles are also described.09-04-2008
20130123596ANALYTE SENSOR - Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory system.05-16-2013
20090018423PATCH FOR EXTRACTING GLUCOSE - Disclosed herein is a patch for extracting glucose. The patch of the present invention includes a frame (01-15-2009
20130131478ANALYTE SENSORS HAVING A SIGNAL-TO-NOISE RATIO SUBSTANTIALLY UNAFFECTED BY NON-CONSTANT NOISE - Systems and methods of use involving sensors having a signal-to-noise ratio that is substantially unaffected by non-constant noise are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted.05-23-2013
20130144142Anti-Interferent Barrier Layers for Non-Invasive Transdermal Sampling and Analysis Device - A system and methods are provided for reducing electrochemical interference in a transdermal sampling and analysis device. A one-step transdermal glucose biosensor may calculate glucose concentrations that are artificially high compared to traditional home blood glucose sensors due to interference, which may be mitigated by forming an anti-interferent barrier layer over a sensing element. The anti-interferent barrier layer may be formed over a sensing layer and may possess a charge type which repels interferent molecules having the same charge type from interacting with the sensing layer disposed below the anti-interferent barrier layer.06-06-2013
20080200789ANALYTE SENSOR - Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory system.08-21-2008
20110224522Method and Apparatus for Providing Dynamic Multi-Stage Amplification in a Medical Device - Methods and apparatus for providing multi-stage signal amplification in a medical telemetry system are provided.09-15-2011
20100286496DUAL ELECTRODE SYSTEM FOR A CONTINUOUS ANALYTE SENSOR - Disclosed herein are systems and methods for a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes first and second working electrodes to measure analyte or non-analyte related signal, both of which electrode include an interference domain.11-11-2010
20110275919OXYGEN ENHANCING MEMBRANE SYSTEMS FOR IMPLANTABLE DEVICES - The present invention relates generally to systems and methods for increasing oxygen availability to implantable devices. The preferred embodiments provide a membrane system configured to provide protection of the device from the biological environment and/or a catalyst for enabling an enzymatic reaction, wherein the membrane system includes a polymer formed from a high oxygen soluble material. The high oxygen soluble polymer material is disposed adjacent to an oxygen-utilizing source on the implantable device so as to dynamically retain high oxygen availability to the oxygen-utilizing source during oxygen deficits. Membrane systems of the preferred embodiments are useful for implantable devices with oxygen-utilizing sources and/or that function in low oxygen environments, such as enzyme-based electrochemical sensors and cell transplantation devices.11-10-2011
20130150690FLUX LIMITING MEMBRANE FOR INTRAVENOUS AMPEROMETRIC BIOSENSOR - A flux limiting layer for an intravenous amperometric biosensor is formed on a substrate to limit a diffusion rate of an analyte from blood to an enzyme electrode. The layer may be formed from ethylene vinylacetate (EVA) dissolved in a solvent such as paraxylene, spray-coated to cover a portion of the electrode, and cured to seal the electrode to the substrate. In a glucose sensor having glucose oxidase disposed on the electrode, thickness and concentration of the EVA layer are optimized to promote a linear output of electrode current as a function of blood glucose concentration.06-13-2013
20130150691Analyte Sensor Devices, Connections, and Methods - Devices associated with on-body analyte sensor units are disclosed. These devices include any of packaging and/or loading systems, applicators and elements of the on-body sensor units themselves. Also, various approaches to connecting electrochemical analyte sensors to and/or within associated on-body analyte sensor units are disclosed. The connector approaches variously involve the use of unique sensor and ancillary element arrangements to facilitate assembly of separate electronics assemblies and sensor elements that are kept apart until the end user brings them together.06-13-2013
20090018425ANALYTE MONITORING: STABILIZER FOR SUBCUTANEOUS GLUCOSE SENSOR WITH INCORPORATED ANTIGLYCOLYTIC AGENT - An analyte sensor including an antiglycolytic agent or a precursor thereof and a chelating agent that stabilizes the antiglycolytic agent positioned proximate to the working electrode of the sensor. Also provided are systems and methods of using the electrochemical analyte sensors in analyte monitoring.01-15-2009
20130150692SYSTEMS AND METHODS FOR PROCESSING SENSOR DATA - Systems and methods for processing sensor data are provided. In some embodiments, systems and methods are provided for calibration of a continuous analyte sensor. In some embodiments, systems and methods are provided for classification of a level of noise on a sensor signal. In some embodiments, systems and methods are provided for determining a rate of change for analyte concentration based on a continuous sensor signal. In some embodiments, systems and methods for alerting or alarming a patient based on prediction of glucose concentration are provided.06-13-2013
20100292555Analyte Monitoring Device and Methods of Use - An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.11-18-2010
20100292553Analyte Monitoring Device and Methods of Use - An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.11-18-2010
20120283538METHOD AND APPARATUS FOR CONTINUOUS ANALYTE MONITORING - Embodiments of the invention provide analyte sensors and sensor systems such as amperometric glucose sensors used in the management of diabetes as well as optimized methods for monitoring analytes using such sensors and sensor systems.11-08-2012
20130158376Temperature-Compensated Analyte Monitoring Devices, Systems, and Methods Thereof - Methods, devices and systems related providing accurate glucose levels in view of temperatures that may adversely affect glucose value.06-20-2013
20130158377Drug Delivery and Substance Transfer Facilitated by Nano-Enhanced Device Having Aligned Carbon Nanotubes Protruding from Device Surface - The present invention relates to a nano-enhanced device for substance transfer between the device and a tissue. The device comprises a substrate with substantially aligned carbon nanotubes anchored within the substrate, and with at least one end of the carbon nanotubes protruding from the substrate. The protruding nanotube ends may be coated with a drug for delivery of the drug into body tissue. The present invention may be incorporated into an angioplasty catheter balloon or into a patch that is worn on the skin. The carbon nanotubes can be grouped in clusters to effectively form nano-needles which can transfer fluid to or from the subdermal tissue. The nano-needles can be used in conjunction with a sensor to ascertain body fluid information such as pH, glucose level, etc.06-20-2013
20130184546Service-Detectable Analyte Sensors and Methods of Using and Making Same - Generally, embodiments of the invention relate to analyte determining devices (e.g., electrochemical analyte monitoring systems) that include an indicator element that provides information relating to service history of the analyte determining devices, including, for example, previous use of the analyte determining devices. Also provided are systems and methods of using the, for example electrochemical, analyte determining devices in analyte monitoring.07-18-2013
20090099434OXYGEN-EFFECT FREE ANALYTE SENSOR - The present invention provides an electrochemical sensor having a sensing chemistry that operates substantially free of any “oxygen effect”. The electrochemical sensors are useful in determining the level of an analyte in a biological sample from a subject. The present invention also provides sensor assemblies including the electrochemical sensors as well as methods of using the same.04-16-2009
20130123595Transdermal Sampling and Analysis Device - Transdermal sampling and analysis device, method and system are provided for non-invasively and transdermally obtaining biological samples from a subject and determining levels of analytes of the obtained biological samples. The transdermal sampling and analysis device, method and system may cause disruption to the skin cells to create capillary-like channels from which biological samples may flow to the transdermal sampling and analysis device. The transdermal sampling and analysis device, method and system may collect the biological samples in a reservoir and transport the biological samples to a sensing chamber. The sensing chamber may contain at least two sensing electrodes coated with a biologically reactive element which reacts with the transported biological sample. The sensing chamber may be configured to mitigate the formation of air bubbles which may impede the transport and distribution of the biological sample across the entirety of the sensing chamber.05-16-2013
20130123594Electrochemical Sensor - Depletion of an analyte on a surface of an electrode is restrained by increasing a quantity of supply of the analyte to the surface of the electrode. An electrochemical sensor includes a substrate, an electrode provided on the substrate, an external layer film provided on the substrate to cover the electrode, and a groove formed in at least a part of the substrate in a direction of the electrode of the substrate.05-16-2013
20110319734SENSOR SYSTEMS HAVING MULTIPLE PROBES AND ELECTRODE ARRAYS - Embodiments of the invention provide amperometric analyte sensors having multiple related structural elements (e.g. sensor arrays comprising a working, counter and reference electrode) and algorithms designed for use with such sensors. While embodiments of the innovation can be used in a variety of contexts, typical embodiments of the invention include glucose sensors used in the management of diabetes.12-29-2011
20130197333ANALYTE SENSOR - The present disclosure relates generally to an electrochemical sensor comprising a membrane layer comprising one or both of an active enzymatic portion and an inactive-enzymatic or non-enzymatic portion, at least one electrode disposed beneath the membrane and either at least one pH sensor or a hematocrit sensor. The present disclosure also relates to methods of adjusting analyte concentration values using a correction factor based on measured pH values and/or measured hematocrit levels.08-01-2013
20130204108VITAL INFORMATION MEASUREMENT DEVICE AND VITAL INFORMATION MEASUREMENT METHOD EMPLOYING SAME - An objective of the present invention is to provide a vital information measurement device which measures vital information using a biosensor, with which it is possible to adjudicate more precisely whether a mounted biosensor is usable, and to alleviate inconsistency in measured values therefrom. Specifically, the present invention provides a vital information measurement device comprising: an input terminal to which a biosensor is connected; a voltage application unit which applies a voltage to the input terminal; an adjudication unit which is connected to the input terminal; a control unit which is connected to the adjudication unit; and a display unit which is connected to the control unit. The control unit causes the adjudication unit to carry out a first adjudication, a second adjudication, and a third adjudication.08-08-2013
20120095307SENSING DEVICE FOR BODY TISSUE PROPERTIES - A device is described for measuring a parameter of living tissue, in particular a glucose level, which parameter affects a response of said tissue to an electric field. The device comprises a substrate (04-19-2012
20130211219Implantable Biosensor Device and Methods of Use Thereof - Sensor devices and methods are provided for detecting the presence or concentration of an analyte in fluid. The device has a reservoir; a working electrode located within the reservoir, a catalyst covering at least part of the working electrode; an oxygen-generating auxiliary electrode in the reservoir; and a reservoir cap to isolate the working and auxiliary electrodes within the reservoir. The device further includes means for selectively rupturing the cap to permit analyte from outside the reservoir to contact the catalyst. The methods may include in vivo glucose monitoring and may include implanting the device in a patient; disintegrating a reservoir cap to permit glucose to enter the reservoir; generating oxygen using the oxygen-generating auxiliary electrode; and using a working electrode to oxidize hydrogen peroxide produced by the reaction of the oxygen with glucose in the presence of glucose oxidase, and thereby detecting endogenous glucose in the patient.08-15-2013

Patent applications in class Blood glucose