Class / Patent application number | Description | Number of patent applications / Date published |
600317000 | By fluorescent emission | 83 |
20080269576 | Light Source for Fluorescence Diagnosis and Photodynamic Therapy - Disclosed herein is a light source device for fluorescence diagnosis and photodynamic therapy comprising: a plurality of light source means having a wavelength range different from each other and providing selected light; a light path coupling means coupling light emitted from the light source means to the incident direction of a light guide; a filtering means selectively transmitting the emitted light based on the wavelength; and a switching device that is directed to an opening/closing means, established at a long distance to be controlled by a remote control device and selecting the kinds of light sources of the light source means to change the modes of the light. Accordingly, the device simplifies the configuration by excluding elements causing errors in the process of fluorescence diagnosis in the diagnostic region. Moreover, the light source device for fluorescence diagnosis and photodynamic therapy couples the light emitted from a combined light source to provide a sufficient light strength in the visible light region, thus improving the illumination quality to increase the accuracy of the diagnosis and further improving the therapeutic efficiency. | 10-30-2008 |
20080281172 | System, method and apparatus for the detection of patient-borne fluorescing nanocrystals - System, method and apparatus wherein a probe employing non-imagining optics is utilized in conjunction with a fluorescing nanocrystal tracer at the body of a patient. Excitation components within the probe working end are utilized to excite the nanocrystals to fluoresce at wavelengths in the near infrared region, such fluorescent energy is homogenized by interacting with involved tissue to provide a uniform fluorescing intensity over the surface of a photo-detector. Initialization and background determination procedures are described along with a technique for determining statistically significant levels of fluorescing activity. | 11-13-2008 |
20080319288 | Saccharide-measuring fluorescent monomer, saccharide-measuring fluorescent sensor substance, and implantable, saccharide-measuring sensor - A saccharide-measuring fluorescence sensor substance including a copolymer of at least the following two compounds (I) and (II) is provided: | 12-25-2008 |
20090018418 | EQUILIBRIUM NON-CONSUMING FLUORESCENCE SENSOR FOR REAL TIME INTRAVASCULAR GLUCOSE MEASUREMENT - Embodiments of the present invention relates to analyte sensors. In particular, the preferred embodiments of the present invention relate to non-consuming intravascular glucose sensors based on fluorescence chemistry. | 01-15-2009 |
20090131773 | Sensor for Detection of Carbohydrate - A sensor for sensing analyte concentration comprises at least two different variants of an appropriate competitive binding assay, the sensor being capable of sensing accurately a required range of analyte concentrations by means of the variants of the assay each being capable of sensing accurately a part only of the required range of analyte concentrations and the variants of the assay being chosen to sense overlapping or adjoining ranges of concentration covering the whole of the required range. | 05-21-2009 |
20100036217 | SYSTEM FOR ANALYZING TISSUE PERFUSION USING CONCENTRATION OF INOCYANINE GREEN IN BLOOD - The present invention relates, in general, to a system for analyzing tissue perfusion using the concentration of indocyanine green and a method of measuring the perfusion rate using the system and, more particularly, to a system for measuring tissue perfusion by injecting indocyanine green into a living body, detecting variation in the concentration of indocyanine green with the passage of time, and analyzing the detected variation, and a method of measuring the perfusion rate using the system. The present invention provides a method of measuring perfusion in a living body, which enables accurate measurement for respective regions in a wide range from a perfusion rate decreased to less than 10% of normal perfusion to a perfusion rate increased to greater than normal perfusion using the above-described mechanism of ICG in a living body, which cannot be conducted using the conventional technology. | 02-11-2010 |
20100210927 | MEANS AND METHODS FOR CYTOMETRIC THERAPIES - A functionalized tip is incorporated into catheters for the cytometric delivery of cells into the brain and other body parts. For use in the brain, the tip forms part of a neurosurgical probe having a proximal end and a distal end. In addition to the functionalized tip, the probe has at least one cell slurry delivery lumen and a plurality of optical fibers configured along the probe, terminating in the tip to provide the photo-optical capability needed to monitor the viability and physiological behavior of the grafted cells as well as certain characteristics of the cellular environment. Details are also presented of the use of a neurocatheter having a cytometric tip of the type disclosed in the invention, as employed within the context of a feedback and control system for regulating the number of cells delivered to the brain of a patient. | 08-19-2010 |
20110082354 | PROBE FOR DETECTING SUBSTANCE IN BODY AND SYSTEM FOR DETECTING SUBSTANCE IN BODY MAKING USE OF THE PROBE - Disclosed is a probe for detecting a substance in the body for detecting a substance in the body in gingival crevicular fluid. The probe includes a gingival sulcus insert section and a sensitive part. The gingival sulcus insert section can be inserted into a gingival sulcus. The sensitive part is arranged on the gingival sulcus insert section and contains a detection substance for permitting optical detection of the substance in the body. A system for detecting a substance in the body is also disclosed. The system for detecting a substance in the body includes the probe for detecting a substance in the body, a light irradiator for irradiating light onto the sensitive part in the probe, and a photodetector for detecting optical information from an inside of the sensitive part upon irradiation of light by the light irradiator. | 04-07-2011 |
20110172510 | RAPID DELIVERY AND/OR WITHDRAWAL OF FLUIDS - The present invention generally relates to systems and methods for delivering and/or withdrawing a substance or substances such as blood or interstitial fluid, from subjects, e.g., from the skin and/or from beneath the skin. In one aspect, the present invention is generally directed to devices and methods for withdrawing or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a fluid transporter (for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to withdraw blood from the subject. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus. For example, blood may be withdrawn from the device, and/or the device may contain sensors or agents able to determine the blood and/or an analyte suspected of being contained in the blood. Other aspects of the present invention are directed at other devices for withdrawing blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like. | 07-14-2011 |
20110224515 | REPLACEABLE MICRONEEDLE CARTRIDGE FOR BIOMEDICAL MONITORING - A replaceable microneedle array for a biomedical monitor is disclosed. The microneedle array includes a plurality of moveable microneedles coated with at least one chemical sensing material coupled with a porous material. The microneedle array also includes a substrate defining wells to house the microneedles. The microneedle array further includes at least one restoring spring element coupled between each microneedle and the substrate such that each of the plurality of microneedles is held at least partially in an associated well. | 09-15-2011 |
20110224516 | MEASUREMENT DEVICES AND METHODS FOR MEASURING ANALYTE CONCENTRATION INCORPORATING TEMPERATURE AND PH CORRECTION - Disclosed herein are methods of estimating an analyte concentration which include generating a signal indicative of the analyte concentration, generating a signal indicative of a temperature, generating a signal indicative of a pH, and transforming the signal indicative of the analyte concentration utilizing an equation of the form of a modified Michaelis-Menten equation depending on Michaelis-Menten parameters, wherein values of the Michaelis-Menten parameters are set based upon data which includes temperature and pH calibration parameters, the signal indicative of a temperature, and the signal indicative of a pH. Also disclosed herein are measurement devices which employ the aforementioned methods. | 09-15-2011 |
20110230739 | TRANSCUTANEOUS ORGAN FUNCTION MEASUREMENT - A sensor plaster ( | 09-22-2011 |
20110237909 | Systems, Circuits and Apparatus For In Vivo Detection of Biomolecule Concentrations Using Fluorescent Tags - Systems are disclosed wherein labeled binding molecules can be provided in vivo to tissue having biomolecules that specifically bind the labeled binding molecule. A first optical radiation is emitted into the tissue in vivo to excite the labeled binding molecule bound to the biomolecule in vivo. A second optical radiation that is emitted by the excited labeled binding molecule, in response to the excitation thereof, can be detected in vivo. Related telemetric-circuits and apparatus are also disclosed. | 09-29-2011 |
20110270056 | DETERMINATION OF PHOTODYNAMIC THERAPY (PDT) TREATMENT PARAMETERS - A photodynamic therapy system and methods determine the amount (concentration) of a photosensitizer agent present in the target tissue. The system may also determine the tissue oxygenation. The system may also determine light dosimetry parameters based on the amount of photosensitizer in the tissue and/or the tissue oxygenation. | 11-03-2011 |
20110270057 | DEVICE AND METHOD FOR DETECTION OF AN IN-VIVO PATHOLOGY - An in-vivo sensing device for detecting in-vivo pathology may include an illumination source for illuminating light onto a tissue external to the device and an optical system for collecting fluorescent light emitted from the tissue onto a light sensor also provided within the device. A method of detecting in-vivo pathology by collecting fluorescent light emitted from a tissue is provided. | 11-03-2011 |
20110306857 | QUANTITATIVE MULTI-SPECTRAL OPTO-ACOUSTIC TOMOGRAPHY (MSOT) OF TISSUE BIOMARKERS - A method of multi-spectral opto-acoustic tomography (MSOT) imaging of a target tissue including a target tissue biomarker includes illuminating the target tissue with an illumination device emitting at least one pulsed illumination pattern at several illumination wavelengths, detecting pressure signals from the target tissue biomarker with a detector device, wherein the pressure signals being produced in the target tissue are in response to the illumination, and reconstructing a quantitative tomographic image of a distribution of the target tissue biomarker in the target tissue, wherein the pressure signals are analyzed using a photon propagation model which depends on an illuminating light fluence in the target tissue and on the illumination wavelengths, at least one spectral processing scheme, and an inversion scheme providing the tomographic image. | 12-15-2011 |
20120016217 | BIOSENSOR FOR HEALTH MONITORING AND USES THEREOF - Disclosed are methods, compositions and kits pertaining to detecting and/or measuring biological analytes. In certain embodiments the disclosure relates to detection and measurement of lactate, pyruvate, oxygen and/or hydrogen peroxide. In some aspects and embodiments provided are biosensors that may be or include nanoparticles, microparticles and/or nano-in-micro matrices. The methods and compositions disclosed may have uses in purpose of diagnosis and treatment of diseases, fitness and health monitoring in sports, in space medicine, in food applications and the food industry, in pharmaceutical applications and the pharmaceutical industry, for fermentation monitoring, and in polymer manufacturing applications. In some embodiments and aspects, the disclosure relates to minimally invasive biosensors and/or biosensors that may be used for continuous monitoring. | 01-19-2012 |
20120046531 | INSERTION OF MEDICAL DEVICES THROUGH NON-ORTHOGONAL AND ORTHOGONAL TRAJECTORIES WITHIN THE CRANIUM AND METHODS OF USING - The invention comprises an elongated device adapted for insertion, including self-insertion, through the body, especially the skull. The device has at least one effector or sensor and is configured to permit implantation of multiple functional components through a single entry site into the skull by directing the components at different angles. The device may be used to provide electrical, magnetic, and other stimulation therapy to a patient's brain. The lengths of the effectors, sensors, and other components may completely traverse skull thickness (at a diagonal angle) to barely protrude through to the brain's cortex. The components may directly contact the brain's cortex, but from there their signals can be directed to targets deeper within the brain. Effector lengths are directly proportional to their battery size and ability to store charge. Therefore, longer angled electrode effectors not limited by skull thickness permit longer-lasting batteries which expand treatment options. | 02-23-2012 |
20120065484 | Determination of a Measure of a Glycation End-Product or Disease State Using Tissue Fluorescence - A method of determining a measure of a tissue state (e.g., glycation end-product or disease state) in an individual. A portion of the tissue of the individual is illuminated with excitation light, then light emitted by the tissue due to fluorescence of a chemical with the tissue responsive to the excitation light is detected. The detected light can be combined with a model relating fluorescence with a measure of tissue state to determine a tissue state. The invention can comprise various light excitation and detection configurations. The invention also can comprise correction techniques that reduce determination errors due to detection of light other than that from fluorescence of a chemical in the tissue. Other biologic information can be used in combination with the fluorescence properties to aid in the determination of a measure of tissue state. The invention also comprises apparatuses suitable for carrying out the method. | 03-15-2012 |
20120101348 | ELECTRONIC ENDOSCOPE SYSTEM HAVING PROCESSOR DEVICE, AND METHOD FOR PROCESSING ENDOSCOPIC IMAGE - White light and excitation light are applied to an internal body part. An electronic endoscope captures a normal image of the internal body part irradiated with the white light, and a special image of autofluorescence emitted from living body tissue of the internal body part irradiated with the excitation light. An object distance detector detects an object distance between a CCD and an inspection area of the internal body part based on the normal image. A binning processing section applies a binning process to the special image. There are two types of binning processes, i.e. an intensity adjustment process and a resolution adjustment process. In the intensity adjustment process, the binning number is increased with increase in the object distance. In the resolution adjustment process, the binning number is decreased with increase in the object distance. Which process to perform is determined by operation on a processing type selector. | 04-26-2012 |
20120165627 | ENDOSCOPIC DIAGNOSIS SYSTEM - An endoscopic diagnosis system includes first and second narrowband light sources for emitting respectively first and second narrowband lights having a wavelength range different from each other, a first image sensor for receiving reflected light of the first narrowband light illuminating a subject to acquire a narrowband light image in a narrowband light observation mode, a second image sensor for receiving first autofluorescence emitted from the subject as the first narrowband light illuminates the subject to acquire a first autofluorescence image in a first autofluorescence observation mode and receiving second autofluorescence emitted from the subject as the second narrowband light illuminates the subject to acquire a second autofluorescence image in a second autofluorescence observation mode, and a light source controller for increasing emission amounts of the first and the second narrowband light in the first and the second autofluorescence observation mode. | 06-28-2012 |
20120179010 | Determination of a Measure of a Glycation End-Product or Disease State Using Tissue Fluorescence of Various Sites - Embodiments of the present invention provide an apparatus suitable for determining properties of in vivo tissue. An illumination system communicates light at a plurality of broadband ranges to an optical probe, which can comprise a flexible probe. Light homogenizers and mode scramblers can be employed in some embodiments. The optical probe can physically contact the tissue, or can be maintained separate from the tissue. The optical probe receives light from the illumination system and transmits it to tissue, and receives light diffusely reflected in response to the broadband light, emitted from the in vivo tissue by fluorescence thereof in response to the broadband light, or a combination thereof. The optical probe can communicate the light to a spectrograph which produces a signal representative of the spectral properties of the light. An analysis system determines a property of the in vivo tissue from the spectral properties. | 07-12-2012 |
20120190945 | DEVICE FOR MONITORING BLOOD VESSEL CONDITIONS AND METHOD FOR MONITORING SAME - The present invention detects a fluorescent signal from AGEs at a blood vessel tissue of an individual to determine the condition of the tissue of the individual. This solves a problem that in measurement of AGEs used in diagnosis of diabetes, data indicative of fluorescent spectrum from AGEs at the skin of a forearm varies depending on where to measure on skin of even the same forearm, which results in variations in measurement values, leading to unreliable data and incorrect measurement result. | 07-26-2012 |
20120220840 | IMAGE PROCESSING DEVICE, ELECTRONIC APPARATUS, ENDOSCOPE SYSTEM, INFORMATION STORAGE DEVICE, AND METHOD OF CONTROLLING IMAGE PROCESSING DEVICE - The image processing device includes: a first image acquisition section that acquires a first image, the first image being an image that includes an object image including information within a wavelength band of white light; a second image acquisition section that acquires a second image, the second image being an image that includes an object image including information within a specific wavelength band; a candidate attention area detection section that detects a candidate attention area based on a feature quantity of each pixel within the second image, the candidate attention area being a candidate for an attention area; a reliability calculation section that calculates reliability that indicates a likelihood that the candidate attention area is the attention area; and a display mode setting section that performs a display mode setting process that sets a display mode of an output image corresponding to the reliability calculated by the reliability calculation section. | 08-30-2012 |
20120226119 | VIVO TUMOR VASCULATURE IMAGING - The present invention relates to non-invasive methods of and uses for in vivo imaging tumor vasculature in a subject comprising detecting a fluorescence labelled anti-CD31 antibody. In a further aspect the present invention relates to non-invasive methods of and uses for in vivo monitoring the therapeutic efficacy of an anti-angiogenic agent in a subject comprising detecting a fluorescence labelled anti-CD31 antibody. In addition, a kit for use in the methods of the present invention is provided which comprises a fluorescence labelled anti-CD31 antibody and means for near-infrared fluorescence imaging to detect the antibody in a subject. | 09-06-2012 |
20120259187 | DYNAMIC COLORECTAL PDT APPLICATION - Dynamic colorectal PDT methods, devices and photosensitizer compositions to treat abnormal cell growth in anal tissue such as perianal and intra-anal intraepithelial neoplasia grade III are presented. Dynamic colorectal PDT method comprises the steps of administering topically, intravenously or orally a photosensitizer composition; irradiating; monitoring treatment parameters before, during and/or after irradiation. Photosensitizer composition comprises Temoporfin and excipients/carriers, appropriate for the application method. An applicator is provided for colorectal PDT treatments enhancing irradiation delivery and monitoring treatment parameters. Preferably, applicator is made of a material, used to monitor the fluence rate simultaneously while doing optical spectroscopy. Measurement probe devices are provided for monitoring PDT treatment parameters in-vivo. A device for colorectal PDT treatment is also provided, comprising laser radiation source operating at about 400 and 800 nm; excitation laser radiation source operating at about 650 nm for fluorescence measurements; multichannel dosimetry device; long pass filter; waveguides and measurement probes. | 10-11-2012 |
20120271128 | MEDICAL APPARATUS - A medical apparatus includes: a storing section in which information concerning a drug kinetics in a living body is stored in advance for each of plural kinds of fluorescent drugs; a processing section that acquires information concerning diagnosis start timing corresponding to a desired fluorescent drug based on information stored in the storing section, information concerning a target region to which the desired fluorescent drug is administered, information concerning a method of administering the desired fluorescent drug to the target region, and information indicating start of the administration of the desired fluorescent drug; and a light source control section that controls radiation of excitation light for exciting the desired fluorescent drug to a stop state until the diagnosis start timing is reached and controls, at and after the diagnosis start timing, the radiation of the excitation light to a state in which the excitation light can be radiated. | 10-25-2012 |
20120277555 | Transmission Fluorometer - This disclosure relates generally to a system and method for noninvasive, non-destructive fluorescent measurement. More specifically, the disclosure provides a non-invasive metrology system and method to monitor levels of fluorescent chemicals in the blood. A major application for the invention is field-based non-invasive blood testing for micro-nutrient deficiency and diseases resulting from it, such as Iron deficient anemia. The invention may help reduce or eliminate the need for blood drawing, sending the sample to a blood lab and having to wait for a result. | 11-01-2012 |
20120310057 | METHOD FOR EVALUATING VASCULAR ENDOTHELIUM FUNCTION AND A SYSTEM THEREFOR - A method for evaluating vascular endothelium function in a human subject comprises monitoring changes in intensity of NADH fluorescence signal emitted from skin tissue cells of an upper limb of said subject as a function of time, wherein said changes result from reactive hyperaemia caused by blocking and releasing blood flow in the same upper limb of said subject. A system for evaluating vascular endothelium function in a human subject comprises a means for illuminating a skin on an upper limb of said subject with exciting light, a means for measuring intensity of fluorescence signal emitted from the skin and recording changes of said intensity of the fluorescence signal over time; and a restriction means for blocking and releasing blood flow in the upper limb of said subject. | 12-06-2012 |
20130072769 | APPARATUS FOR THE NON-INVASIVE MEASUREMENT OF TISSUE FUNCTION AND METABOLISM BY DETERMINATION OF STEADY-STATE FLUORESCENCE ANISOTROPY - A non-invasive measurement of biological tissue reveals information about the function of that tissue. Polarized light is directed onto the tissue, stimulating the emission of fluorescence, due to one or more endogenous fluorophors in the tissue. Fluorescence anisotropy is then calculated. Such measurements of fluorescence anisotropy are then used to assess the functional status of the tissue, and to identify the existence and severity of disease states. Such assessment can be made by comparing a fluorescence anisotropy profile with a known profile of a control. | 03-21-2013 |
20130085353 | OPTICAL BACKSCATTERING DIAGNOSTICS - A system for non-invasive measurement of parameters relating to a biological tissue comprising: a plurality of light sources, each operable to emit a light signal with one or more predetermined wavelengths; a light detector for detecting light from the tissue as a result of illumination by the sources, and means for applying modulation functions to the light emitted to implement code division multiplexing, each source being associated with a different function, wherein the functions are selected so that there is substantially no cross correlation between them, and wherein the sources have overlapping spectra. | 04-04-2013 |
20130090538 | Method and System to Monitor the State and Function of the Cervix and Effects of Treatments for the Cervix - A method operable to more accurately monitor the state and function of the cervix is provided. Embodiments of the present invention relate generally to detection of fluorescence from the female mammalian cervix. More particularly, embodiments of the present invention relate to predicting true term and preterm labor and delivery, characterizing the function and state of the cervix, and for assessing and monitoring the efficacy of treatments for the cervix. Embodiments of the present disclosure use light induced fluorescence (LIF) via a non-invasive optical probe to accurately and quantitatively measure changes in the cervical tissue during pregnancy and labor. As gestational age increases, the LIF decreases. Ideally, cervical collagen should be at a minimum just prior to delivery. The present invention can be used to monitor the state and function of the cervix during pregnancy, as well as efficacy of cervical treatments during pregnancy. | 04-11-2013 |
20130090539 | FLUOROCHROME MATERIAL AND METHOD FOR USING THE SAME - It is an object of the present invention to extend the usefulness of an iron-salen complex. The present invention is a new fluorochrome material containing Chemical Formula (I) below. However, M is Fe, Cr, Mn, Co, Ni, Mo, Ru, Rh, Pd, W, Re, Os, Ir, Pt, Nd, Sm, Eu, or Gd. | 04-11-2013 |
20130096400 | SAMPLING AND TESTING DEVICE FOR THE HUMAN OR ANIMAL BODY | 04-18-2013 |
20130102862 | Systems and Methods for Visualizing Ablated Tissue - Systems and methods for visualizing ablated tissue are disclosed. In some embodiments, a system for imaging tissue includes a catheter having an expandable balloon at a distal end, an illumination device positioned within the balloon for propagating light from an external light source for illuminating a tissue being treated to excite native nicotinamide adenine dinucleotide hydrogen (NADH) in the tissue, and an imaging device positioned within the balloon for detecting fluorescence from the illuminated tissue, the imaging device being configured to communicate detected NADH fluorescence to an external fluorescence camera. | 04-25-2013 |
20130116518 | RENAL FUNCTION ANALYSIS METHOD AND APPARATUS - A method for measuring a glomerular filtration rate in a mammalian kidney comprises a source of reporter and marker fluorescent molecules. The fluorescent molecules are introduced into the blood stream of a mammalian subject. Over a period of time, a measurement of the intensities of the reporter and marker fluorescent molecules is taken. A ratio is calculated to determine the health of the subject's kidney. This method measures volume of plasma distribution based on a fluorescence of a marker molecule relative to a fluorescence of a reporter molecule. | 05-09-2013 |
20130131471 | SYSTEMS, DEVICES, AND METHODS FOR IDENTIFYING PORTIONS OF A WOUND FILLER LEFT AT A TISSUE SITE - Methods for treating a wound include positioning a wound filler having a coating agent containing a fluorescent material proximate the wound. The wound filler is removed after a time period. The wound is then scanned using a fluorescence scanner to determine whether a portion of the wound filler remains at the wound. In response to the portion of the wound filler remaining at the wound, the portion of the wound filler is removed. Other methods and systems are presented. | 05-23-2013 |
20130137944 | METHOD FOR SIMULTANEOUSLY DETECTING FLUORESCENCE AND RAMAN SIGNALS FOR MULTIPLE FLUORESCENCE AND RAMAN SIGNAL TARGETS, AND MEDICAL IMAGING DEVICE FOR SIMULTANEOUSLY DETECTING MULTIPLE TARGETS USING THE METHOD - Method pertains to a medical imaging device for simultaneously detecting fluorescence and Raman signals for multiple fluorescence and Raman signal targets. The method includes: injecting at least one marker particle including Raman markers and receptors into the body of an animal, which can be a human; irradiating a laser beam onto the body of the animal; and detecting the optical signals emitted by the marker particle after the irradiation of the laser beam separately as fluorescence signals and Raman signals. The simultaneous detection of multiple targets may be performed even without scanning optical signals emitted by the marker particle individually with different optical fibers. As an examination may be performed by injecting surface-enhanced Raman marker particles, into which fluorescent components are introduced, into the body of the animal using a spray or the like, weak Raman signals may be augmented so as to obtain a more accurate diagnosis result in real time. | 05-30-2013 |
20130158374 | System for Glycated Protein Detection - A method of detecting the presence of glycated proteins or peptides (GPs) in a sample comprises carrying out the steps of assessing the sample for fluorescence, subjecting the sample to UV radiation, and reassessing the sample for an increase in fluorescence relative to any fluorescence assessed in said first assessing step, an increase in fluorescence at said reassessing step being indicative of the presence of GPs. The method may be useful for detecting disease such as diabetes. | 06-20-2013 |
20130197327 | ANALYTE SENSOR - An analyte sensor is disclosed that comprises: | 08-01-2013 |
20130211215 | HYPEROSMOTIC PREPARATIONS COMPRISING 5-AMINOLEVULINIC ACID OR DERIVATIVE AS PHOTOSENSITIZING AGENT - Provided herein are improved methods of photodynamic treatment and diagnosis of cancer and non-cancerous conditions in the gastrointestinal tract, e.g. in the colon, and in particular hyperosmotic enema preparations for use in such methods. The enema preparations comprise a photosensitizer which is 5-aminolevulinic acid (5-ALA) or a precursor or derivative thereof, e.g. a 5-ALA ester, in combination with at least one hyperosmotic agent. The methods and preparations herein described are particularly suitable for use in photodynamic methods of treating and/or diagnosing colorectal cancer. | 08-15-2013 |
20130217985 | METHOD FOR EVALUATING BLUSH IN MYOCARDIAL TISSUE - Vessel perfusion and myocardial blush are determined by analyzing fluorescence signals obtained in a static region-of-interest (ROI) in a collection of fluorescence images of myocardial tissue. The blush value is determined from the total intensity of the intensity values of image elements located within the smallest contiguous range of image intensity values containing a predefined fraction of a total measured image intensity of all image elements within the ROI. Vessel (arterial) peak intensity is determined from image elements located within the ROI that have the smallest contiguous range of highest measured image intensity values and contain a predefined fraction of a total measured image intensity of all image elements within the ROI. Cardiac function can be established by comparing the time differential between the time of peak intensity in a blood vessel and that in a region of neighboring myocardial tissue both pre and post procedure. | 08-22-2013 |
20130245406 | CONFOCAL PHOTOACOUSTIC MICROSCOPY WITH OPTICAL LATERAL RESOLUTION - A method for determining a ratio of hemoglobin absorption within a biological tissue using a handheld device is provided. The method includes focusing at least one light pulse into a predetermined area inside an object using at least one excitation wavelength, wherein a fluorescence signal is based on at least a local excitation optical fluence and properties of fluorophores in the predetermined area. The method further includes receiving a photoacoustic signal emitted by the object in response to the at least one light pulse, the photoacoustic signal being a product of the local excitation optical fluence, an optical absorption coefficient of hemoglobin, and an acoustic detection sensitivity. The method further includes determining the ratio of hemoglobin absorption based on a hemoglobin absorption coefficient that is based at least partially on the fluorescence signal and the photoacoustic signal. | 09-19-2013 |
20130338457 | METHOD AND APPARATUS FOR DETECTING DISEASES ASSOCIATED WITH THE EYE - Disease may be detected, monitored, etc. by detecting metabolic dysfunction in a patient's eyes. In one embodiment of an apparatus, an excitation light is generated by an excitation light source to induce autofluorescence in an ocular tissue (e.g., retinal tissue), wherein the excitation light excites flavoprotein autofluorescence (FA) and minimizes the excitation of non-flavoprotein autofluorescence. At least a single image representing the induced ocular tissue autofluorescence is captured. The at least single image is intensified to increase the signal strength of the ocular tissue autofluorescence. The at least single image is analyzed to generate an indicator of whether a patient has one or more of eye damage, a disease that causes eye damage, or to generate an indicator of the progression of a disease, an indicator of the effectiveness of a treatment, a personalized treatment for a subject, etc. | 12-19-2013 |
20140031647 | IN VIVO FLOW CYTOMETRY BASED ON CELLULAR AUTOFLUORESCENCE - The present invention generally provides methods and systems for performing in vivo flow cytometry by using blood vessels as flow chambers through which flowing cells can be monitored in a live subject in vivo without the need for withdrawing a blood sample. In some embodiments, one or more blood vessels are illuminated with radiation so as to cause a multi-photon excitation of an exogenous fluorophore that was previously introduced into the subject to label one or more cell types of interest. In some other embodiments, rather than utilizing an exogenous fluorophore, endogenous (intrinsic) cellular fluorescence can be employed for in vivo flow cytometry. The emission of fluorescence radiation from such fluorophores in response to the excitation can be detected and analyzed to obtain information regarding a cell type of interest. | 01-30-2014 |
20140046150 | METHOD AND DEVICE FOR MONITORING AN EXTRACORPOREAL BLOOD TREATMENT OF A PATIENT - The present invention pertains to Method for monitoring a dialysis treatment of a patient, preferably for monitoring a haemodialysis, haemodiafiltration and/or peritoneal dialysis treatment of a patient, the method including the steps of:
| 02-13-2014 |
20140073885 | MULTI-CHANNEL MEDICAL IMAGING SYSTEM - A medical imaging system provides simultaneous rendering of visible light and fluorescent images. The system may employ dyes in a small-molecule form that remain in a subject's blood stream for several minutes, allowing real-time imaging of the subject's circulatory system superimposed upon a conventional, visible light image of the subject. The system may provide an excitation light source to excite the fluorescent substance and a visible light source for general illumination within the same optical guide used to capture images. The system may be configured for use in open surgical procedures by providing an operating area that is closed to ambient light. The systems described herein provide two or more diagnostic imaging channels for capture of multiple, concurrent diagnostic images and may be used where a visible light image may be usefully supplemented by two or more images that are independently marked for functional interest. | 03-13-2014 |
20140088384 | INTRA-OPERATIVE MOLECULAR IMAGING - A system for detecting tumor margins includes a topical protease-specific, fluorescence imaging probe that is activatable by enzymatic activation to produce a visually differentiated signal upon topical application to a targeted cancer cell that secretes an enzyme that activates the protease-specific, fluorescence imaging probe, means for topically administering the imaging probe to the cancer cell; and an imaging device to detect activation of the imaging probe administered to the cancer cell. | 03-27-2014 |
20140114150 | Method And System For Using Cherenkov Radiation To Monitor Beam Profiles And Radiation Therapy - A system for providing monitored radiation therapy has a high energy radiation source, apparatus for excluding uncontrolled ambient light, and apparatus for collecting light emitted from a subject. The system has apparatus for spectrally analyzing the collected light, and a processor for determining oxygenation or other metabolic function of tissue within the subject from spectral analysis of the collected light. The system monitors radiation therapy by providing a beam of high energy radiation; collecting Cherenkov and/or photoluminescent light from the subject, the light generated along the beam; spectrally analyzing the light; and determining oxygenation or metabolic function of tissue from the spectral analysis. Beam profile of the system is calibrated by imaging from multiple angles Cherenkov and/or photoluminescent light emitted by a phantom placed in the beam in lieu of a subject, captured images are analyzed to determine beam profile. | 04-24-2014 |
20140171764 | SYSTEMS AND METHODS FOR NERVE IMAGING - Systems and methods for imaging are presented. The method includes producing excitation light configured to induce fluorescence in an imaging agent that selectively binds to a target species in a region of interest (ROI) of a subject that also includes a background species. A first and a second spectral region are selected such that a determined difference between fluorescence corresponding to the target and the background species in the first spectral region differs from a corresponding difference in the second spectral region. First and second fluorescence images are generated from the fluorescence corresponding to the first and second spectral regions. Additionally, a fluorescence ratio for the background species in the first and second fluorescence image is determined. The first fluorescence image is then multiplied or divided with the determined ratio to generate an intermediate image that is subtracted from the second fluorescent image to reconstruct a background-subtracted image. | 06-19-2014 |
20140187879 | System and Method for Laser Imaging and Ablation of Cancer Cells Using Fluorescence - A fluorescence imaging device detects fluorescence in parts of the visible and invisible spectrum, and projects the fluorescence image directly on the human body, as well as on a monitor, with improved sensitivity, video frame rate and depth of focus, and enhanced capabilities of detecting distribution and properties of multiple fluorophores. Direct projection of three-dimensional visible representations of florescence on three-dimensional body areas advantageously permits view of it during surgical procedures, including during cancer removal, reconstructive surgery and wound care, etc. A NIR laser and a human visible laser (HVL) are aligned coaxially and scanned over the operating field of view. When the NIR laser passes over the area where the florescent dye is present, it energizes the dye which emits at a shifted NIR frequency detected by a photo diode. The HVL is turned on when emission is detected, providing visual indication of those positions. | 07-03-2014 |
20140206961 | METHOD AND APPARATUS FOR IN VIVO COLLECTION OF CIRCULATING BIOLOGICAL COMPONENTS - The invention relates generally to in vivo collection of circulating molecules, tumor cells and other biological markers using a collecting probe. The probe is configured for placement within a living organism for an extended period of time to provide sufficient yield of biological marker for analysis. In some embodiments of the invention, active attraction of biological markers are provided. A partial or complete analytic/detection assembly may also be integrated with the probe. | 07-24-2014 |
20140213860 | ARRANGEMENT AND DEVICES CONFIGURED FOR CARRYING OUT OPTICAL ABSORPTION SPECTROSCOPY - An implantable fluorescent concentrator is configured to be inserted in vivo as a subcutaneous light source for optical absorption spectroscopy of surface-near tissue layers. As a result, certain and reliable results of the optical absorption spectroscopy are achievable. Furthermore, various analytes with different absorption properties are certainly and reliably quantifiable. | 07-31-2014 |
20140235973 | MEASUREMENT OF A FLUORESCENT ANALYTE USING TISSUE EXCITATION - An apparatus and method for noninvasive measurement of a fluorescent analyte concentration in the blood of a patient by exciting the blood and the analyte at two wavelength ranges and measuring the emission spectrum of the fluorescent analyte when (i) the difference of emission intensities at the excitation wavelength ranges of the fluorescent analyte is greater than that of background fluorophores, and (ii) when blood absorbance at the two excitation wavelength ranges is similar. An apparatus and method for measurement of a fluorescent analyte concentration in the blood of a patient is provided. | 08-21-2014 |
20140249391 | TISSUE VISUALIZATION FOR RESECTION - Methods for distinguishing between two interspersed biological tissues, for procedures such as surgical resection, include exposing the tissues to at least two components, a first of which components produces or is capable of producing a detectable signal, and the other of which components either blocks the produced signal of the first component or activates the first component to produce the detectable signal. One of the components is selectively taken up by one of the tissues at a concentration which is greater than the concentration by which it is taken up by the other tissue to provide a distinguishable difference in the detectable signal originating from the two tissues. | 09-04-2014 |
20140296667 | SAMPLING AND TESTING DEVICE FOR THE HUMAN OR ANIMAL BODY | 10-02-2014 |
20140296668 | BIOMETRIC DEVICE, BIOMETRIC METHOD, PROGRAM, AND RECORDING MEDIUM - Provided is a biometric device including a light source unit arranged facing a first part on a surface of an organism and configured to irradiate the first part with excitation light, and a light-reception unit arranged facing a second part adjacent to the first part on the surface of the organism and configured to receive fluorescence light which is generated by the excitation light exciting a first body substance of the organism and emitted from the second part. | 10-02-2014 |
20140378794 | Physiological Measurement Using Wearable Device - A wearable device includes a detector configured to detect a response signal transmitted from a portion of subsurface vasculature, the response signal being related to binding of a clinically-relevant analyte to functionalized particles present in a lumen of the subsurface vasculature. Program instructions stored in a computer readable medium of the device, and executable by a processor, may cause the device to determine a concentration of the clinically-relevant analyte based on the response signal detected by the detector; determine whether a medical condition is indicated based on at least the concentration of the clinically-relevant analyte; and, in response to a determination that the medical condition is indicated, transmit data representative of the medical condition via the communication interface. The device may also include a signal source configured to transmit an interrogating signal into the portion of subsurface vasculature, thereby generating a response signal in response to the interrogating signal. | 12-25-2014 |
20150018645 | DISPOSABLE CALIBRATION END-CAP FOR USE IN A DERMOSCOPE AND OTHER OPTICAL INSTRUMENTS - A disposable tubular end cap for a dermoscope for examining the skin of an animal. The end cap has one end for receiving light from and transmitting light to the dermoscope, a removable calibration target disposed at the other end having optical characteristics similar to a standard skin type, and an identifier disposed on the end cap. The identifier uniquely identifies the end cap and associates it with both data regarding light emitted from the skin of an animal and calibration data derived from the calibration target. Animal tissue may be examined to identify lesions using a plurality of wavelengths and a plurality of polarizations. | 01-15-2015 |
20150080686 | ATHEROSCLEROTIC PLAQUE DETECTION - An apparatus detects atherosclerotic plaques. The apparatus includes an electronic processing device that determines a level of fluorescence sensed by a sensor at a second infrared wavelength in response to exposure of at least part of an artery to radiation at a first infrared wavelength and determines a fluorescence indicator using the level of fluorescence. The fluorescence indicator is indicative of the presence, absence or degree of an atherosclerotic plaque. | 03-19-2015 |
20150087937 | CURCUMIN DERIVATIVES FOR AMYLOID-BETA PLAQUE IMAGING - The present invention provides curcumin-derived near infrared (NIR) imaging probes. Upon interacting with amyloid β aggregates, these probes undergo a range of changes, qualifying them as “smart” probes. The inventors have demonstrated that probes of the invention have the capacity to monitor the progression of Alzheimer's disease in an in vivo animal model. In addition, the present invention encompasses probes useful as PET imaging agents, MRI imaging agents and multimodal imaging agents, as well as related methods of detecting and imaging amyloid β aggregates and plaques. | 03-26-2015 |
20150148629 | Biopsy Device with Integrated Optical Spectroscopy Guidance - An optical spectroscopy probe for providing optical spectroscopy guidance of a mechanical biopsy procedure, and a tissue biopsy device including an optical spectroscopy probe. The optical spectroscopy probe is positionable in a lumen of a mechanical biopsy device. The probe may enable optical spectroscopy guidance in biopsy procedures, include brain biopsy procedures. | 05-28-2015 |
20150148630 | METHOD AND DEVICE FOR DETECTING FLUORESCENCE RADIATION - A method for detecting fluorescence radiation from a fluorescence agent, includes:
| 05-28-2015 |
20150148631 | CLASS OF NEAR INFRARED OPTICAL PROBES FOR BIOLOGICAL APPLICATIONS - 2,5-Bis(benzoxazol-2′-yl)benzene-1,4-diol derivatives (Zinhbo derivatives) are used to detect zinc ions and have particular application in vivo and in vitro. Zinhbo derivatives upon excitation give a florescence response emission that can be used to determine the presence of zinc cation in solution. Zinhbo derivatives complexed with zinc cations upon excitation can produce a florescence response emission in the visible and near infrared range. Zinhbo derivatives complexed with zinc cations exhibit a large stoke shift between the excitation and emission wavelengths. | 05-28-2015 |
20150327753 | Systems and Methods for Visualizing Ablated Tissue - Systems and methods for visualizing ablated tissue are disclosed. In some embodiments, a system for imaging tissue comprising: a catheter having a distal end and a proximal end; an inflatable balloon disposed about the distal end of the catheter; and an optical housing extending from the distal end of the catheter into the balloon, the optical housing being configured to position inside the balloon a light source for illuminating a tissue outside the balloon and a camera for imaging the illuminated tissue. | 11-19-2015 |
20160022180 | LONG-TERM IMPLANTABLE MONITORING SYSTEM & METHODS OF USE - Methods and systems include a long-term implantable ultra-filtrate monitoring system that uses micro-porous membranes to produce an ultra-filtrate of tissue interstitial fluid or blood plasma. The ultra-filtrate is transported through a sensor to detect a level of analyte in the ultra-filtrate. The long-term implantable fluid monitoring system thus includes a first porous catheter, a second porous catheter, a sensor configured to measure an amount of analyte in fluid, and a pump configured to move fluid through the first porous catheter to the sensor and from the sensor through the second porous catheter. | 01-28-2016 |
20160022214 | MEASURING DEVICE - A measuring device that can obtain a stable measurement result is realized. The measuring device includes a measuring portion ( | 01-28-2016 |
20160029930 | COMPACT BIOSENSOR OF MATRIX METALLOPROTEINASE WITH CADMIUM FREE QUANTUM DOTS - The invention provides a quantum dot (QD) modified optical fiber-based biosensor which characterizes matrix metalloproteinase (MMP) enzyme activity at pain signaling sites in the central nervous system (CNS) in vivo. Related systems and peptide biomarker screening methods are also provided. | 02-04-2016 |
20160045113 | Ultraviolet Streptococcus Detection - An ultraviolet light is used to rapidly differentiate bacterial versus viral causes of a sore throat by the amount of fluorescent light emitted, allowing for a rapid, painless, and simple means to diagnose strep throats. The invention is especially useful in diagnosing strep throat in children. | 02-18-2016 |
20160066953 | SENSOR EMBEDDING DEVICE AND SENSOR EMBEDDING SYSTEM - A sensor embedding device according to the present disclosure is a sensor embedding device which embeds a sensor in a subject, the sensor having a sensing region in which to detect a state of the subject, including: a needle to be inserted in the subject, the needle having a hole; a sensor retainer to retain the sensor so that the sensor is ready to be embedded inside the subject in such a manner that the sensing region is oriented in a predetermined direction; and a movable section to move the sensor into the subject with a slide of the sensor retainer inside the hole. | 03-10-2016 |
20160082236 | TRANSPLANTATION DEVICE AND METHOD OF USE - Embodiments of the present disclosure relates to an implantable structure and a two stage method for cell and/or tissue transplantation. The implantable structure is configured to promote vascularization prior to cell and/or tissue transplantation, thereby allowing for implanted cells and/or tissues to have increased viability. In some embodiments, oxygen sensitive dyes can be used to determine levels of vascularization of the device. | 03-24-2016 |
20160089198 | SURGICAL DEVICE WITH AN END-EFFECTOR ASSEMBLY AND SYSTEM FOR MONITORING OF TISSUE DURING A SURGICAL PROCEDURE - A medical instrument is provided and includes a housing and a shaft coupled to the housing. The shaft has a proximal end and a distal end. An end-effector assembly is disposed at the distal end of the shaft. The end-effector assembly includes first and second jaw members. At least one of the first and second jaw members is movable from a first position wherein the first and second jaw members are disposed in spaced relation relative to one another to at least a second position closer to one another wherein the first and second jaw members cooperate to grasp tissue therebetween. The medical instrument also includes one or more light-emitting elements and one or more light-detecting elements configured to generate one or more signals indicative of tissue florescence. The one or more light-emitting elements are adapted to deliver light energy to tissue grasped between the first and second jaw members. | 03-31-2016 |
20160103307 | METHOD AND SYSTEM FOR STOKES INTERFERENCE STIMULATED FLUORESCENT SCATTERING FOR IN-VIVO IMAGING - A microscopy system includes a first laser emitting a first laser pulse, the first laser pulse being a pump beam; a second laser emitting a second laser pulse, the second laser pulse being spectrally isolated for generating a probe beam and a donut beam; an optical device for combining the pump beam, the probe beam and the donut beam into a combined laser pulse, the probe beam and donut beam having a phase difference that causes a reduction of a focal volume of the combined laser pulse; a galvanometer scanning system for delivering the combined laser pulse to a focal spot in a focal plane, wherein the reduction of the focal volume of the combined laser pulse initiates a stimulated emission of a targeted molecule, the stimulated emission having dipole-like backscatter; and a sensor for enabling imaging of the dipole-like backscatter. | 04-14-2016 |
20160129131 | Shielded Targeting Agents, Methods, and In Vivo Diagnostic System - A system is provided which includes nanoparticle conjugates configured to bind with a tumor cell, the nanoparticle conjugate comprising a nanoparticle, at least one targeting entity bound to the nanoparticle, and at least one shielding entity that shields at the at least one targeting entity, the nanoparticle, or both; a body-mountable device mounted on an external surface of a living body and configured to detect a tumor cell binding response signal transmitted through the external surface, wherein the tumor cell binding response signal is related to binding of the nanoparticle conjugates with one or more tumor cells; and a processor configured to non-invasively detect the one or more tumor cells based on the tumor cell response signal. Nanoparticle conjugates and methods for use for treating or imaging tumor cells are also provided. | 05-12-2016 |
20160143522 | Visualization Catheters - Methods and systems for ablation mapping and ablation procedures are provided. In some embodiments, a catheter for visualizing ablated tissue comprises a catheter body; a support assembly extending past a distal end of the catheter body, the support assembly having a lumen therethrough; and a balloon having a proximal end and a distal end, wherein the proximal end of the balloon is attached to the catheter body and the distal end of the balloon is attached to the support assembly, the balloon having an opening at the distal end in alignment with the lumen of the support assembly to provide a continuous path from the catheter body to outside of the balloon. | 05-26-2016 |
20160151003 | OPTICAL MEASUREMENT DEVICE | 06-02-2016 |
20160151055 | BIOPSY DEVICE AND METHOD FOR OBTAINING A TOMOGRAM OF A TISSUE VOLUME USING SAME | 06-02-2016 |
20160157762 | OPTICAL MEASUREMENT DEVICE - An optical measurement device includes a light source irradiating a test subject with first light L | 06-09-2016 |
20160157763 | FLUORESCENCE OBSERVATION DEVICE, ENDOSCOPIC SYSTEM, PROCESSOR DEVICE, AND OPERATION METHOD - A fluorescence observation device includes an oxygen saturation calculation section, a reference region setting section, a region-of-interest setting section, a normalized fluorescence intensity calculation section, and a fluorescent image generation section. The oxygen saturation calculation section calculates the oxygen saturation of the subject for each pixel. The reference region setting section sets a reference region of the subject based on the oxygen saturation. The region-of-interest setting section sets a region of interest of the subject. The normalized fluorescence intensity calculation section calculates a normalized fluorescence intensity indicating the normalized emission intensity of the fluorescence by dividing the region-of-interest fluorescence intensity, which is calculated using the pixel value of the region of interest, by the reference fluorescence intensity calculated using the pixel value of the reference region of a fluorescent image signal obtained by imaging the subject with the fluorescence. The fluorescent image generation section generates a fluorescent image based on the normalized fluorescence intensity. | 06-09-2016 |
20160183774 | ENDOSCOPE SYSTEM, PROCESSOR DEVICE, OPERATION METHOD, AND DISTANCE MEASUREMENT DEVICE - There are provided an endoscope system, a processor device, an operation method, and a distance measurement device for accurately measuring the observation distance even if a colorant or residues are present in a subject. An endoscope system | 06-30-2016 |
20160249808 | IMPROVED TRANSCUTANEOUS ORGAN FUNCTION MEASUREMENT | 09-01-2016 |
20170231605 | TISSUE SAMPLING, CANCER DETECTION AND TREATMENT METHODS | 08-17-2017 |
20180020920 | INSTRUMENT FOR ACQUIRING CO-REGISTERED ORTHOGONAL FLUORESCENCE AND PHOTOACOUSTIC VOLUMETRIC PROJECTIONS OF TISSUE AND METHODS OF ITS USE | 01-25-2018 |