Class / Patent application number | Description | Number of patent applications / Date published |
600318000 | Determining constituents in eye | 50 |
20080214913 | Surface-Enhanced Spectroscopy with Implanted Biosensors - The present invention provides a spectroscopic apparatus, a method and a computer program product for determining the concentration of an analyte of a fluid that flows through a capillary vessel of a biological sample. The spectroscopic apparatus makes use of an imaging system for determining the position of at least one biosensing substrate that has been implanted into the biological sample in the proximity of the capillary vessel but outside the capillary vessel. The biosensing substrate is capable of inducing surface-enhanced spectroscopic effects and is preferably adapted to reversibly and selectively bind a certain analyte or molecule of the fluid, to which the vessel wall of the capillary vessel is at least semi-permeable. By performing a spectroscopic analysis not directly inside the capillary vessel but in close proximity to the capillary vessel, the signal-to-noise ratio of the spectroscopic signals obtained can be appreciably enhanced while disadvantageous scattering and interference effects can be minimized. | 09-04-2008 |
20080221416 | System and method for detection of macular degeneration using spectrophotometry - Embodiments of the present invention relate to a system and method of detecting or monitoring macular degeneration in a patient. One embodiment of the present invention includes emitting a first light into the patient's retinal tissue at a first wavelength, emitting a second light into the patient's retinal tissue at a second wavelength, detecting the first and second lights after dispersion by the retinal tissue, and determining an amount of lipid proximate the retinal tissue based on the detected first and second lights. | 09-11-2008 |
20090005660 | Device for measuring concentrations of constituents of tear sample - A medical diagnostic method utilizes a surface plasmon resonance apparatus provided with a sensing surface. A tear sample from an eye of a patient is placed into contact with the sensing surface. The surface plasmon resonance apparatus is then operated to determine concentrations of solutes such as salt and antigenic analytes in the tear sample. | 01-01-2009 |
20090018419 | BIOSENSORS, COMMUNICATORS, AND CONTROLLERS MONITORING EYE MOVEMENT AND METHODS FOR USING THEM - Biosensor, communicator, and/or controller apparatus, systems, and methods are provided for monitoring movement of a person's eye. The apparatus includes a device configured to be worn on a user's head, a light source for directing light towards one or both eyes of the user, one or more image guides on the device for viewing one or both eyes of the user, and one or more cameras carried on the device and coupled to the image guides for acquiring images of the eyes and/or the user's surroundings. The apparatus may include a cable and/or a transmitter for transmitting image data from the camera to a remote location, e.g., to processor and/or display for analyzing and/or displaying the image data. A system including the apparatus may be used to monitor one or more oculometric parameters, e.g., pupillary response, and/or to control a computer using the user's eyes instead of a mouse. | 01-15-2009 |
20090036761 | Noninvasive measurement of chemical substances - Utilization of a contact device placed on the eye in order to detect physical and chemical parameters of the body as well as the non-invasive delivery of compounds according to these physical and chemical parameters, with signals being transmitted continuously as electromagnetic waves, radio waves, infrared and the like. One of the parameters to be detected includes non-invasive blood analysis utilizing chemical changes and chemical products that are found in the conjunctiva and in the tear film. A transensor mounted in the contact device laying on the cornea or the surface of the eye is capable of evaluating and measuring physical and chemical parameters in the eye including non-invasive blood analysis. The system utilizes eye lid motion and/or closure of the eye lid to activate a microminiature radio frequency sensitive transensor mounted in the contact device. The signal can be communicated by wires or radio telemetered to an externally placed receiver. The signal can then be processed, analyzed and stored. Several parameters can be detected including a complete non-invasive analysis of blood components, measurement of systemic and ocular blood flow, measurement of heart rate and respiratory rate, tracking operations, detection of ovulation, detection of radiation and drug effects, diagnosis of ocular and systemic disorders and the like. | 02-05-2009 |
20090099428 | Method of blood oxygen saturation by ophthalmic measurement - A method of performing a diagnostic characterization and assessment of a patients' eye is provided. The method comprising the extraction of measurement data relating to a predetermined portion of the eye, for example the fovea, at a plurality of wavelengths and fitting the extracted measurement data to a model of the eye, for example a linear adaptive model. The data subsequently analyzed to determine at least one of a common retinal behavior, a deviation from the common retinal behavior, and an oximetry value. In the case of the measurement data relating to the fovea of the eye then the oximetry value is indicative of the blood oxygen saturation of the choroid vasculature of the eye. Further analysis based upon storing the measurement data and/or analysis from each test allows for the changes within the patients eye to be established unlike prior art solutions, and identifying the changes with an element of the eye such as the retina, cornea, crystalline lens, etc. | 04-16-2009 |
20090118601 | IR SPECTROGRAPHIC APPARATUS AND METHOD FOR DIAGNOSIS OF DISEASE - A method for detecting disease in a patient includes providing infrared (IR) light and coupling the IR light through direct lens coupling or through a first group of one or more optical fibers. IR light is reflected from a portion of the patient and collected by a lens arrangement or a second group of one or more optical fibers. The reflected IR light is dispersed into its spectrum which is detected and analyzed. An apparatus suitable for diagnosing a disease in a patient includes an IR light source and optical fiber or direct lens coupling of IR light onto a body part or fluid of the patient. Reflected light from the patient is optically dispersed using a prism or grating. An IR focal plane array receives the optically dispersed light. The spectrum of the reflected IR light is used to provide a diagnosis of disease in the patient by identifying various disease markers or chemical fingerprints. The method and apparatus are capable of non-invasively detecting disease markers in a patient. | 05-07-2009 |
20090149726 | Spectroscopic detection of malaria via the eye - Methods, apparatus, and systems for detecting hemozoin and diagnosing malaria infection are disclosed. | 06-11-2009 |
20100249548 | OCULAR SENSOR FOR THE DETECTION OF AN ANALYTE IN EYE WATER - An ocular sensor ( | 09-30-2010 |
20110184261 | METHOD AND SYSTEM FOR MONITORING HYDRATION - A device for measuring a hydration status based on an analyte concentration in a subject. The device includes: a light source configured for illuminating at least a portion of an anterior region of an eye of the subject with incident light having a substantially broad illumination spectrum at an angle substantially tangential to the surface of the eye; an optical collector configured for detecting reflected light from the at least a portion of the anterior region of the eye; an analyzer configured for analyzing the detected reflected light; and a processor configured to determine the analyte concentration level in the subject based on the analyzed reflected light, wherein the processor determines a hydration status of the subject based on the analyte concentration level and reference data. | 07-28-2011 |
20110184262 | NON-INVASIVE OCULAR MONITORING - A device for measuring an analyte concentration level in a subject. The device includes: a light source configured for illuminating at least a portion of an anterior region of an eye of the subject with incident light having a substantially broad illumination spectrum at an angle substantially tangential to the surface of the eye; an optical collector configured for detecting reflected light from the at least a portion of the anterior region of the eye; an analyzer configured for analyzing the detected reflected light; and a processor configured to determine the analyte concentration level in the subject based on the analyzed reflected light. | 07-28-2011 |
20120245440 | Dual Wavelength Scanning System - The invention provides high speed, low cost scanning suitable for time domain OCT systems. According to the preferred embodiment, the apparatus includes a piezo scanning device and partial reflecting surfaces that simultaneously generate two sets of multiple reference signals at two different wavelengths that can span different regions of a target enabling acquiring target information from a large range within the target. In one embodiment of the invention, information from both the front region and the back region of an eye is acquired in a coordinated manner. | 09-27-2012 |
20120296180 | SPECTROSCOPIC DETECTION OF MALARIA VIA THE EYE - Methods, apparatus, and systems for detecting hemozoin and diagnosing malaria infection are disclosed. | 11-22-2012 |
20130131472 | NON-INVASIVE OCULAR MONITORING - A device for measuring an analyte concentration level in a subject. The device includes: a light source configured for illuminating at least a portion of an anterior region of an eye of the subject with incident light having a substantially broad illumination spectrum at an angle substantially tangential to the surface of the eye; an optical collector configured for detecting reflected light from the at least a portion of the anterior region of the eye; an analyzer configured for analyzing the detected reflected light; and a processor configured to determine the analyte concentration level in the subject based on the analyzed reflected light. | 05-23-2013 |
20130172700 | OPTICAL DETECTION METHOD - An method for detection of β-amyloid in aqueous humor, lens, and retina of eye or the deposit of the combination of αβ-crystallin and β-amyloid in lens is provided. A light is emitted to a testing area in the eye. The light frequency is selected according to an absorption spectrum of the test substance, and the frequency is equal or close to a resonant excitation frequency of one of the electronic molecular energy levels of the substance, so as to excite the substance to generate resonance-enhanced Raman effect or pre-resonance Raman effect to form a detection spectrum. The concentration of the substance could be estimated by a peak intensity of the detection spectrum. | 07-04-2013 |
20130217986 | METHOD AND SYSTEM FOR PREDICTING AN AMYLOIDOSIS STATUS - An exemplary method of predicting an amyloidosis status involves obtaining a profile of drusen in a periphery of a retina of a subject; and using the profile to predict an amyloidosis status. Another exemplary method of predicting an amyloidosis status involves identifying a subject, the amyloidosis status of which is desired; and obtaining a profile of drusen in a periphery of a retina of the subject. Another exemplary method of predicting an amyloidosis status involves analyzing a profile of drusen in a periphery of a retina of a subject to predict an amyloidosis status of the subject. Another exemplary method of predicting an amyloidosis status involves comparing a profile of drusen in a periphery of a retina of a subject to a control; and predicting an amyloidosis status of the subject. | 08-22-2013 |
20130225951 | DETERMINATION OF OXYGEN SATURATION IN A TISSUE OF VISUAL SYSTEM - A method and system of acquisition and processing of data representing oxygen saturation (OS) value of a tissue of a visual system of a subject, such as the optic nerve head and overlying artery and vein. The data is acquired at pre-determined discrete spectral points, including at least two isosbestic points, as a discrete reflectance spectrum, with the use of a multi-spectral optical imaging system that simultaneously produces a plurality of two-dimensional spectrally-discrete images by segmenting an incoming light front with secondary objectives. The OS value is assessed based on determination of areas bound by an acquired discrete reflectance spectrum and an isosbestic line. | 08-29-2013 |
20140046151 | PHYSIOLOGICAL MONITORING USING AN OCULAR PROBING SYSTEM AND METHOD - A method and system perform physiological monitoring. The system includes a first light source and a plurality of optical waveguide couplers, each of the plurality of optical waveguide couplers being arranged at a different predetermined spatial location on an ocular insert to be placed on an eye. The system also includes a plurality of optical waveguides. Each optical waveguide carries light from a second light source to a respective one of the plurality of optical waveguide couplers and carries a received signal from the respective one of the plurality of optical waveguide couplers. A processor receives the received signal from each of the plurality of optical waveguides and monitors a parameter based on the received signal. | 02-13-2014 |
20140194708 | CONTACT LENS WITH INTEGRATED PULSE OXIMETER - Apparatus, systems and methods employing a contact lens having a pulse oximetry sensor to detect information indicative of a blood oxygen content and/or pulse rate of a wearer of the contact lens, are provided. In some aspects, a contact lens includes a substrate that forms at least part of a body of the contact lens and a pulse oximetry sensor located on or within the substrate that detects information associated with at least one of blood oxygen content or a pulse rate of a wearer of the contact lens. The pulse oximetry sensor comprises one or more light emitting diodes that illuminate a blood vessel of at least one of a region of an eye or an eyelid and a detector that receives light reflected from the blood vessel and generates the information. | 07-10-2014 |
20150038809 | ENCAPSULATED ELECTRONICS - An eye-mountable device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor includes a working electrode and a reference electrode that reacts with an analyte to generate a sensor measurement related to a concentration of the analyte in a fluid to which the eye-mountable device is exposed. An example assembly process includes: forming a sacrificial layer on a working substrate; forming a first layer of a bio-compatible material on the sacrificial layer; providing an electronics module on the first layer of the bio-compatible material, forming a second layer of the bio-compatible material to cover the electronics module; and annealing the first and second layers of the bio-compatible material together to form an encapsulated structure having the electronics module fully encapsulated by the bio-compatible material. | 02-05-2015 |
20150359440 | ASSESSING CIRCULATORY FAILURE - The present invention relates to a method of identifying or monitoring circulatory failure in a subject, which method comprises assessing the subject's microcirculation in respect of the following parameters: (a) functional capillary density (FCD); (b) heterogeneity of the FCD; (c) capillary flow velocity; (d) heterogeneity of capillary flow velocity; (e) oxygen saturation of microvascular erythrocytes (SmvO | 12-17-2015 |
600319000 | Glucose | 21 |
20080249381 | Combined Apparatus For Measuring the Blood Glucose Level From an Ocular Fluid - A combined apparatus for measuring the blood glucose level from an ocular fluid comprises a hand-held fluorescence photometer (D | 10-09-2008 |
20090240124 | Systems and Methods for Measuring the Concentration of Analytes in the Human Eye - A method for determining the concentration of an analyte within a volume located between the cornea and the iris of an eye includes determining an index of refraction of a volume disposed between a cornea and an iris of an eye, the volume including an analyte. Based upon the index of refraction of said volume, the concentration of the analyte within the volume is determined. | 09-24-2009 |
20100063371 | DEVICE FOR MEASURING AN ANALYTE IN AN EYE FLUID - The invention proposes a manual measuring appliance ( | 03-11-2010 |
20100113901 | Contact lens integrated with a biosensor for the detection of glucose and other components in tears - The present invention provides contact lens with integrated biosensor for the continuous, non-invasive monitoring of physiological glucose by employing biocompatible nanostructure-laden lens materials. These contact lenses can be worn by diabetics who can colorimetrically see changes in their contact lens color or other fluorescence-based properties, giving an indication of tear and blood glucose levels. This invention for the glucose biosensor based on the new disposal contact lens provides a safe, convenient and non-expensive glucose sensing device. The sensing device disclosed herein provides an efficient and noninvasive solution for monitoring blood glucose. | 05-06-2010 |
20100152558 | NON-INVASIVE GLUCOSE METER - An apparatus and method for measuring a concentration of a substance in an eye using a retro-reflected measurement light beam having a first wavelength at which the substance has a non-zero first absorption coefficient and a retro-reflected reference light beam having a second wavelength at which the substance has a second absorption coefficient which is substantially equal to zero. The apparatus further includes a detector positionable to receive the retro-reflected measurement light beam and the retro-reflected reference light beam. The detector is responsive to light having the first wavelength by generating a measurement signal and responsive to light having the second wavelength by generating a reference signal. The apparatus further includes an electrical circuit coupled to the detector. The electrical circuit is responsive to the measurement signal and the reference signal to measure the concentration of the substance in the eye. | 06-17-2010 |
20100185066 | APPARATUS FOR MEASURING BLOOD GLUCOSE CONCENTRATIONS - An apparatus for measuring ocular and/or blood glucose levels comprises
| 07-22-2010 |
20100234704 | Non-Invasive Polarimetric Apparatus and Method for Analyte Sensing in Birefringent Media - A noninvasive polarimetric apparatus used to measure levels of a substance in a sample in the presence of dynamically changing sample birefringence is provided. A polarization system generates multiple states of polarized light which interact with the sample. An analyzer system receives a signal from the sample and generates a secondary signal. This signal is detected and then processed to measure levels of a substance in a sample that may be have time varying birefringent components. | 09-16-2010 |
20110105868 | METHOD AND DEVICE FOR MEASURING DISSOLVED SUBSTANCES IN HUMAN OR ANIMAL INTRAOCULAR FLUID - The present invention relates to the non-invasive optical measurement of glucose and other dissolved substances in human or animal intraocular fluid. For this purpose, a method and devices for carrying out the method are proposed. The method according to the invention takes advantage of the fact that the wave dependence of optical activity is fundamentally different from corneal birefringence. The optical activity of substances dissolved in the intraocular fluid, such as glucose, lactate, ascorbic acid or amino acids, is scaled as a first approximation with the reciprocal value of the wavelength square. Upon closer review, higher orders must be taken into consideration and effectively an exponent varying from a value of 2 may occur. For glucose, the exponent shall be denoted as 2+x | 05-05-2011 |
20120215079 | NONINVASIVE EYE-PROPERTY MONITORING, INCLUDING AQUEOUS-HUMOR GLUCOSE MONITORING AS AN INDICATION OF BLOOD GLUCOSE LEVEL - An eye-property monitoring system and method for performing the steps of (1) illuminating the eye from at least one light source whose wavelength interacts with internal eye properties in an optically active manner, (2) controlling, to make known and stable, the operating-power/light-output level of the source, (3) by such illuminating, producing light-source eye reflections including (a) multiple internal reflections within the outer structure of the eye, and (b) linked with those internal reflections at least one resulting outbound reflection, (4) monitoring the outbound-reflection to detect therein the reflection level associated with the at least one source, and (5) associating such detected reflection level as an indication of certain eye properties, such as aqueous glucose concentration. | 08-23-2012 |
20120259188 | Flexible Eye Insert and Glucose Measuring System - Disclosed is a flexible insert ( | 10-11-2012 |
20120277556 | APPARATUS FOR NON-INVASIVE BLOOD GLUCOSE MONITORING - An apparatus for non-invasive blood glucose monitoring includes a light source for generating at least one ray of light, a beam splitter with a focusing function leads the light into an eyeball and focuses on the eyeball, a set of photo detectors for measuring optical rotatory distribution (ORD) information and absorption energy information of the reflected light reflected from the eyeball and transmitted through the first beam splitter to the set of photo detectors, and a processing unit. The processing unit receives and processes the ORD information and the absorption energy information to obtain an ORD difference and an absorption energy difference resulting from the light emitted from the light source and the reflected light transmitted to the set of photo detectors, and analyzes the ORD difference and the absorption energy difference to obtain a glucose information to read the blood glucose information. | 11-01-2012 |
20120277557 | METHOD FOR NON-INVASIVE BLOOD GLUCOSE MONITORING AND METHOD FOR ANALYSING BIOLOGICAL MOLECULE - A method for non-invasive blood glucose monitoring includes the following steps. At least one ray of light is emitted from at least one light source. The light emitted from the light source is leaded into an eyeball and focused on the eyeball through a first beam splitter. The reflected light reflected from the eyeball is transmitted through the first beam splitter to a set of photo detectors. Optical rotatory distribution (ORD) information and absorption energy information of the reflected light transmitted to the set of photo detectors are measured. ORD difference and absorption energy difference resulting from the light emitted from the light source and the reflected light transmitted to the set of photo detectors are obtained. Glucose information is obtained by analyzing the ORD difference and the absorption energy difference, and since glucose information has a corresponding relationship with blood glucose information, blood glucose information may be read. | 11-01-2012 |
20140107438 | MEASURING DEVICE AND GLUCOSE CONCENTRATION MEASUREMENT METHOD OF THE MEASURING DEVICE - The inventive concept relates to a measuring device. The measuring device irradiates a first beam including a polarization component and a second beam which is a wavelength swept laser having a coherence length previously set and can measure a glucose concentration of an aqueous humor by measuring an optical path length and the rotation amount of a polarization plane respectively from a first output beam and a second output beam being output from an eye. | 04-17-2014 |
20140171765 | APPARATUS FOR NON-INVASIVE GLUCOSE MONITORING - An apparatus for non-invasive glucose monitoring includes a light source for emitting at least one ray of light; a first beam splitter, a set of photo detectors for measuring optical rotatory distribution (ORD) information and absorption energy information; a reference component receiving the light from the first beam splitter, and the light reflected by the reference component being transmitted to the set of photo detectors by the first beam splitter, wherein the light emitted from the light source is transmitted to the set of photo detectors by the first beam splitter and the eyeball to form a first optical path, the light emitted from the light source is transmitted to the set of photo detectors by the first beam splitter and the reference component to form a second optical path; and a processing unit receiving and processing the ORD information and the absorption energy information to obtain a glucose information. | 06-19-2014 |
20140180041 | APPARATUS FOR NON-INVASIVE GLUCOSE MONITORING - An apparatus for non-invasive glucose monitoring includes a first light source for emitting at least one ray of first light; a first beam splitter with a focusing function; a set of photo detectors for measuring optical rotatory distribution (ORD) information and absorption energy information of the first light reflected from the eyeball and transmitted through the first beam splitter to the set of photo detectors, and the first light emitted from the first light source being transmitted to the set of photo detectors by the first beam splitter and the eyeball to form an optical path; a processing unit receiving and processing the ORD information and the absorption energy information to obtain glucose information; and an eye positioning device including a second beam splitter disposed on the optical path between the first beam splitter and the eyeball and a camera for receiving image information transmitted from the second beam splitter. | 06-26-2014 |
20140249392 | METHOD AND DEVICE FOR MEASURING DISSOLVED SUBSTANCES IN HUMAN OR ANIMAL INTRAOCULAR FLUID - Non-invasive optical measurement of glucose and other dissolved substances in human or animal intraocular fluid. A method takes advantage of the fact that the wave dependence of optical activity is fundamentally different from corneal birefringence. The optical activity of substances dissolved in the intraocular fluid, such as glucose, lactate, ascorbic acid or amino acids, is scaled as a first approximation with the reciprocal value of the wavelength square. In contrast, corneal birefringence is scaled with the reciprocal value of the wavelength and therefore behaves considerably different from the optical activity. For the method according to the invention, a physical model is used, which describes the influence on the polarization of measurement radiation by the components of the eye, particularly by the intraocular fluid and the cornea. | 09-04-2014 |
20140364709 | Non-Invasive Ocular Analyte Sensing System - A noninvasive method and apparatus for determining analyte concentration (e.g., glucose) in a subject that includes measuring light refraction from at least a portion one or more structures. One example of such structure is the subject's iris. | 12-11-2014 |
20160081556 | AN APPARATUS CONFIGURATED TO AND A PROCESS TO PHOTOACOUSTICALL IMAGE AND MEASURE A STRUCTURE AT THE HUMAN EYE FUNDUS - An apparatus configured to photoacoustically image and measure a structure at the human eye fundus or components, substances, cells, tissue, or analytes within the eye and within the blood vessels of the eye including an emitter element for emitting electro-magnetic radiation, a transition element for delivering the electro-magnetic radiation into an eye, a detection element for detecting an acoustic wave and converting the acoustic wave into a digital wave signal, an analysis element for processing the digital wave signal into an image or measurement or both, and a display element for displaying a representation of the image and/or the measurement. The apparatus additionally includes a coupling member, the coupling member being configured and arranged to acoustically couple the eye to the detection element such that the acoustic wave generated within the eye can be guided onto the detection element. | 03-24-2016 |
20160095533 | NON-INVASIVE IN SITU GLUCOSE LEVEL SENSING USING ELECTROMAGNETIC RADIATION - System and method of using electromagnetic radiation signals to non-invasively test a glucose level in a subject. During operation, an incident beam of Terahertz waves is generated and projected onto the surface of the eyeball, which is naturally reflected by a tear layer. The reflected Terahertz waves are detected and characterized to determine the reflection characteristics of the tear layer, e.g., an axial ratio of reflection coefficients in two polarization orientations. Provided with the determined axial ratio and according to a predetermined correlation among axial ratio, tear glucose level and blood glucose level, the current blood glucose level in the subject can be derived and presented to a user. | 04-07-2016 |
20160095540 | NON-INVASIVE IN SITU GLUCOSE LEVEL SENSING USING ELECTROMAGNETIC RADIATION - System and method of using electromagnetic radiation signals to non-invasively test a glucose level in a subject. During operation, an incident beam of Terahertz waves is generated and projected onto the surface of the eyeball, which is naturally reflected by a tear layer. The reflected Terahertz waves are detected and characterized to determine the reflection characteristics of the tear layer, e.g., an axial ratio of reflection coefficients in two polarization orientations. Provided with the determined axial ratio and according to a predetermined correlation among axial ratio, tear glucose level and blood glucose level, the current blood glucose level in the subject can be derived and presented to a user. | 04-07-2016 |
20160374564 | AN APPARATUS CONFIGURATED TO AND A PROCESS TO PHOTOACOUSTICALL IMAGE AND MEASURE A STRUCTURE AT THE HUMAN EYE FUNDUS - An apparatus configured to photoacoustically image and measure a structure at the human eye fundus or components, substances, cells, tissue, or analytes within the eye and within the blood vessels of the eye including an emitter element for emitting electro-magnetic radiation, a transition element for delivering the electro-magnetic radiation into an eye, a detection element for detecting an acoustic wave and converting the acoustic wave into a digital wave signal, an analysis element for processing the digital wave signal into an image or measurement or both, and a display element for displaying a representation of the image and/or the measurement. The apparatus additionally includes a coupling member, the coupling member being configured and arranged to acoustically couple the eye to the detection element such that the acoustic wave generated within the eye can be guided onto the detection element. | 12-29-2016 |
600320000 | Hemoglobin | 1 |
20080306364 | Doppler velocimetry of retinal vessels and application to retinal vessel oximetry - A new model based on ray tracing is developed to estimate power spectral properties in laser Doppler velocimetry of retinal vessels and to predict the effects of laser beam size and eccentricity as well as absorption of laser light by oxygenated and reduced hemoglobin. There is described the model and show that it correctly converges to the traditional rectangular shape of the Doppler shift power spectrum, given the same assumptions, and that reduced beam size and eccentric alignment cause marked alterations in this shape. The changes in the detected total power of the Doppler-shifted light due to light scattering and absorption by blood can also be quantified with this model and may be used to determine the oxygen saturation in retinal arteries and veins. The potential of this approach is that it uses direct measurements of Doppler signals originating only from moving red blood cells. The invention opens new avenues for retinal vessel oximetry. | 12-11-2008 |
600321000 | Using fluorescent emission determination | 7 |
20110028807 | Contact lens for collecting tears and detecting at least one analyte - Utilization of a contact device placed on the eye in order to detect physical and chemical parameters of the body as well as the non-invasive delivery of compounds according to these physical and chemical parameters, with signals being transmitted continuously as electromagnetic waves, radio waves, infrared and the like. One of the parameters to be detected includes non-invasive blood analysis utilizing chemical changes and chemical products that are found in the conjunctiva and in the tear film. A transensor mounted in the contact device laying on the cornea or the surface of the eye is capable of evaluating and measuring physical and chemical parameters in the eye including non-invasive blood analysis. The system utilizes eye lid motion and/or closure of the eye lid to activate a microminiature radio frequency sensitive transensor mounted in the contact device. The signal can be communicated by wires or radio telemetered to an externally placed receiver. The signal can then be processed, analyzed and stored. Several parameters can be detected including a complete non-invasive analysis of blood components, measurement of systemic and ocular blood flow, measurement of heart rate and respiratory rate, tracking operations, detection of ovulation, detection of radiation and drug effects, diagnosis of ocular and systemic disorders and the like. | 02-03-2011 |
20110040161 | Device for generating a detectable signal based upon concentration of at least one substance - Utilization of a contact device placed on the eye in order to detect physical and chemical parameters of the body as well as the non-invasive delivery of compounds according to these physical and chemical parameters, with signals being transmitted continuously as electromagnetic waves, radio waves, infrared and the like. One of the parameters to be detected includes non-invasive blood analysis utilizing chemical changes and chemical products that are found in the conjunctiva and in the tear film. A transensor mounted in the contact device laying on the cornea or the surface of the eye is capable of evaluating and measuring physical and chemical parameters in the eye including non-invasive blood analysis. The system utilizes eye lid motion and/or closure of the eye lid to activate a microminiature radio frequency sensitive transensor mounted in the contact device. The signal can be communicated by wires or radio telemetered to an externally placed receiver. The signal can then be processed, analyzed and stored. Several parameters can be detected including a complete non-invasive analysis of blood components, measurement of systemic and ocular blood flow, measurement of heart rate and respiratory rate, tracking operations, detection of ovulation, detection of radiation and drug effects, diagnosis of ocular and systemic disorders and the like. | 02-17-2011 |
20120203086 | APPARATUS AND METHOD FOR NON-INVASIVELY DETECTING DISEASES THAT AFFECT STRUCTURAL PROPERTIES IN BIOLOGICAL TISSUES - Apparatus and methods for spectroscopic analysis of biological tissues to classify an individual as diabetic or non-diabetic, or to determine the probability, progression or level of a disease or medical condition in an individual. | 08-09-2012 |
20140357969 | LASER SCANNING METHOD FOR MEASURING IN VIVO SUBSTANCES - In a laser scanning method for measuring in vivo substances, wavelength of the anti-Stokes line is made greater than wavelength absorption band of the specific substance, the wavelength of the probe light is shifted from the wavelength of the anti-Stokes line by a shift amount of Raman scattering of the specific substance, and the wavelength of the Stokes light is shifted from the wavelength of the probe light by the shift amount of the Raman scattering of the specific substance. According to this, density (concentration and distribution) of lutein in an eye fundus is measured quantitatively and non-invasively from a signal strength level of the anti-Stokes line. | 12-04-2014 |
20150065824 | METHODS AND APPARATUS TO FORM OPHTHALMIC DEVICES INCORPORATING FLUORESCENCE DETECTORS - Ophthalmic devices with media inserts that have fluorescence based analysis elements upon or within them may be utilized to analyze and monitor fluid for certain components. Methods and devices for active ophthalmic devices based on fluorescence based analysis elements may also be formed. More specifically, the fluorescence based analysis elements may be useful for analyzing an analyte such as glucose in a fluid sample. | 03-05-2015 |
20160029892 | VITAL STAIN VISUALIZATION IN OPHTHALMIC SURGICAL PROCEDURES AND ASSOCIATED DEVICES, SYSTEMS, AND METHODS - A method of imaging in an ophthalmic surgical procedure can include determining an excitation wavelength of light associated with a vital stain; transmitting light having the excitation wavelength; determining an emission wavelength of light associated with the vital stain; filtering light using a first optical element to allow transmission of light having the emission wavelength and to block light having the excitation wavelength. An ophthalmic surgical imaging system can include a light source, one or more optical elements, an image sensor, a computing device, and/or a display device to visualize target biological tissue stained with a fluorescent vital stain. A method of imaging in an ophthalmic surgical procedure can include determining a wavelength of light that increases the visual contrast of a vital stain; transmitting light having the determined wavelength; and receiving a reflection of the transmitted light such that target biological tissue stained by the vital stain is accentuated. | 02-04-2016 |
20160183859 | SYSTEM AND METHOD FOR DETECTING AMYLOID PROTEINS - In accordance with an embodiment of the invention, there is provided a device and method for detecting an amyloid protein in an eye of a mammal. A method comprises illuminating the eye with a light source having at least one of a wavelength property, a polarization property or a combination thereof, each appropriate to produce fluorescence in at least an amyloid-binding compound when the amyloid-binding compound is bound to the amyloid protein, the amyloid-binding compound having been introduced to the eye and specifically binding to the amyloid protein indicative of the amyloidogenic disorder; and determining a time decay rate of fluorescence for at least the fluorescence produced by the amyloid-binding compound bound to the amyloid protein, the determining permitting distinguishing of the presence of the amyloid-binding compound bound to the amyloid protein in the eye based on at least the time decay rate. | 06-30-2016 |