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Infrared, visible light, or ultraviolet radiation directed on or through body or constituent released therefrom

Subclass of:

600 - Surgery


600309000 - Measuring or detecting nonradioactive constituent of body liquid by means placed against or in body throughout test

Patent class list (only not empty are listed)

Deeper subclasses:

Class / Patent application numberDescriptionNumber of patent applications / Date published
600322000 Determining blood constituent 637
600316000 Glucose 133
600317000 By fluorescent emission 41
600318000 Determining constituents in eye 32
600344000 Mounting structure (e.g., belt, etc.) 20
600342000 Light conducting fiber inserted in body 11
600314000 Foreign substance 9
600315000 Bilirubin 7
600311000 Partial pressure of constituent 2
20090192367ANALYTE DETECTION SYSTEM WITH PERIODIC SAMPLE DRAW AND BODY FLUID ANALYZER - An embodiment of a system for analyzing a body fluid of a patient comprises a fluid transport network having a patient end configured to provide fluid communication with the body fluid in the patient and a fluid delivery point spaced from the patient end. A pump system is coupled to the fluid transport network. The pump system has an infusion mode in which the pump system is operable to pump an infusion fluid toward the patient end of the fluid transport network and a draw mode in which the pump system is operable to draw the body fluid from the patient into the fluid transport network through the patient end. At least one electrochemical test element is located near the fluid delivery point of the fluid transport network. The electrochemical test element is positioned to receive a portion of the body fluid delivered to the delivery point by the fluid transport network. An analyte detection system is configured to receive the test element and to measure at least one analyte in the portion of the body fluid.07-30-2009
20120232364METHOD AND APPARATUS FOR OPTOACOUSTIC MONITORING OF BLOOD COMPONENTS IN A BLOOD FLOW - Described is an apparatus and method of optoacoustic monitoring of blood concentrations of one or more constituents by directing a flow of a patient's blood through a substantially transparent vessel to optoacoustically detect a concentration of one or more constituents. To detect constituents, pulses of laser light can be passed through the blood flow at one or more frequencies in order to generate an altered laser emission from the exposed blood, and/or induce detectable optoacoustic responses from the constituents. The detectable responses can be detected and measured by analyzing an alteration of the laser emissions and/or the frequency, slope and/or amplitude of the optoacoustic responses for different constituents in the blood.09-13-2012
20100049017MULTI-WAVELENGTH OPTICAL DEVICES AND METHODS OF USING SAME - Multi-wavelength optical apparatus includes an optical emitter, and an energy transition layer positioned adjacent to the optical emitter. The energy transition layer generates multi-wavelength electromagnetic radiation when monochromatic light from the optical emitter passes therethrough. The energy transition layer includes a plurality of luminescent films, and each film is configured to luminesce at a respective different wavelength range when monochromatic light from the optical emitter passes therethrough. The plurality of luminescent films may be arranged in contacting face-to-face relationship or may be arranged in an array. The luminescent films may include rare-earth doped oxides, phosphors, metal-doped oxides, rare-earth doped nitrides, nanostructures, and/or nanostructured films, etc. The optical emitter may be a light emitting diode (LED), a laser diode (LD), an organic light-emitting diode (OLED), a resonant cavity light emitting diode (RCLED), and/or an edge-emitting diode (EELED).02-25-2010
20130030264METHOD OF PROVIDING UNIFORM DISTRIBUTION OF LIGHT IN A PHOTOTHERAPY DEVICE - A method of computing peak spectral irradiance, the method comprising characterizing at least one light source to determine an irradiance distribution pattern, generating multiple density cones in a three dimensional model based on the irradiance distribution pattern, positioning the multiple density cones in a desired layout, measuring density of irradiance at one or more locations, and optimizing the positioning of the at least one light source to obtain a desired irradiance distribution.01-31-2013
20100113897CONTINUOUS ANALYTE MONITORING ASSEMBLY AND METHODS OF USING THE SAME - A continuous analyte monitoring assembly is adapted to assist in determining an analyte level of a fluid. The monitoring assembly includes a housing, electronics, an implantable sensor and a cannula. The housing has a bottom in which the bottom forms a recess. The electronics are located within the housing and assist in determining an analyte level of a fluid sample. The sensor moves from a retracted position to an inserted position using the recess. The cannula assists in placing the implantable sensor.05-06-2010
20130079605TRANSDERMAL ANALYTE EXTRACTION & DETECTION SYSTEM AND THE METHOD THEREOF - The present invention relates to an active transdermal analyte detection system performing extraction and detection of body analytes comprising of a patch accepting at least one electrical input; a plurality of transducers configured for converting input electrical energy to different forms of energies for activating extraction procedure; a controller configured for providing the control signals, intensity, sequence, nature, and timing information for the different energies supplied to the said patch vide said transducers; and at least one layer/compartment configured for either collection of extracted fluids and/or delivering at least one reagent formulation that detects the body analyte on activation and a method for performing transdermal extraction and detection of body fluids using said electronic patch.03-28-2013
20090018415Methods and Apparatuses for Noninvasive Determinations of Analytes using Parallel Optical Paths - The present invention provides methods and apparatuses for accurate noninvasive determination of tissue properties. Some embodiments of the present invention comprise an optical sampler having an illumination subsystem, adapted to communicate light having a first polarization along a first path to a tissue surface; a collection subsystem, adapted to collect light having a second polarization communicated from the tissue along a second path after interaction with the tissue; wherein the first polarization is different from the second polarization; and wherein the first path and the second path are substantially parallel for at least of portion of each path.01-15-2009
20090156913CERAMIC EMITTER SUBSTRATE - A ceramic emitter substrate has a substrate body with top and bottom sides and a cavity disposed on the top side. Bonding pads are disposed within the cavity and solder pads are disposed on the bottom side. Light emitting diodes (LEDs) are electrically connected to the bonding pads. Low-resistance conductors are disposed within the ceramic substrate body so as to interconnect the bonding pads and the solder pads. The interconnect is configured so that the LEDs can be individually activated as an array via row and column drive signals applied to the solder pads.06-18-2009
20090156912IMPLANTABLE OPTICAL SENSOR AND METHOD FOR MANUFACTURE - An implantable optical sensor and associated manufacturing method include a sensor housing having an inner surface and an outer surface and a window formed in the housing extending between the housing inner surface and the housing outer surface. An opto-electronic device enclosed within the housing and having a photonic surface is operatively positioned proximate the window for emitting light through the window or detecting light through the window. An optical coupling member is positioned between the opto-electronic device and the window for reducing light reflection at a surface within the implantable optical sensor.06-18-2009
20100105995BONE DENSITY METER - A bone density meter including a light emission unit which emits light toward a surface of a user's body. A light reception unit receives the light emitted from the light emission unit toward the body surface and propagated in a portion of the body that includes bone. A bone density computation unit determines the bone density based on the amount of light received by the light reception unit. The light emission unit emits light toward the body surface at a portion having a thin subcutis, and the light reception unit receives the light propagated in the body through the portion at which the subcutis is thin.04-29-2010
20100105994BIOLOGICAL INFORMATION MEASURING APPARATUS - There is provided a biological information measuring apparatus, which permits to release constriction of capillary vessels a human body to provide stable measurement results of biological information and a proper S/N ratio. The biological information measuring apparatus 04-29-2010
20090124873BIOCOMPONENT CONCENTRATION MEASURING DEVICE - To provide a biocomponent concentration measuring device capable of determining which organ in an ear cavity is in condition for a measurement, the biocomponent concentration measuring device is provided with an infrared ray detector 05-14-2009
20090240123DETERMINING RELATIVE BLOOD HEMATOCRIT LEVEL USING AN AUTOMATED INTEGRATED FLUID DELIVERY AND BLOOD ACCESS DEVICE - Devices and methods for determining the fluid characteristics of a blood sample may include the assessment of a pressure waveform of a fluid sample having a pre-determined volume passed through or out of a flow restrictor. The interface between the blood and other fluids in the tubing line of the blood monitoring system may also be assessed. These assessments may be used alone or in combination to generate estimates of other fluid characteristics, such as the hematocrit of a blood sample. This information may be used for the real-time determination of change of hematocrit levels in a patient's blood while the patient is being transfused with intravenous fluids or other vascular products, or to provide adjustment factors for other blood assays affected by the hematocrit or other blood parameters.09-24-2009
20090093693Micro-invasive method for painless detection of analytes in extracellular space - A method of detecting at least one analyte in extra-cellular spaces includes the step of inserting a microprobe through the stratum corneum toward the stratum basale of the skin of a subject into extra-cellular spaces containing interstitial fluid having at least one analyte to be detected, said microprobe having a diameter at its tip no larger than approximately 10-50 microns. The method further includes optically testing for a predetermined analyte in the extra-cellular space adjacent the distal end of the microprobe without drawing a sample of the interstitial fluid. Preferably the microprobe body includes a sensor layer covering the distal optical tip of the microprobe body, the sensor layer being adapted to interact with a predetermined analyte to be detected in the interstitial fluid, and an optical detector responsive to interaction of the sensor layer with the predetermined analyte to signal detection of said predetermined analyte.04-09-2009
20110015506IMAGING DEVICE, METHOD THEREOF, AND PROGRAM - To realize an imaging device, imaging method and program capable of improving image quality. This invention controls light sources so as to irradiate a body with irradiation light of a luminance level higher than that in the air arriving at the body, adjusts the imaging sensitivity of a solid imaging element for performing photoelectric conversion on pattern scattered light obtained through the inside of the body, and masks the luminance level deterioration region of a pattern image obtained from the solid imaging element to treat the masked image as an image to be composed with a reference image.01-20-2011
20110015505METHOD FOR DATA REDUCTION AND CALIBRATION OF AN OCT-BASED PHYSIOLOGICAL MONITOR - The present invention relates to a method and system for estimating blood analyte levels using a noninvasive optical coherence tomography (OCT) based physiological monitor. An algorithm correlates OCT-based estimated blood analyte data with actual blood analyte data determined by other methods, such as invasively. OCT-based data is fit to the obtained blood analyte measurements to achieve the best correlation. Once the algorithm has generated sets of estimated blood analyte levels, it may refine the number of sets by applying one or more mathematical filters. The OCT-based physiological monitor can be calibrated using an Intensity Difference plot or the Pearson Product Moment Correlation method.01-20-2011
20130060104FILTERED DETECTOR ARRAY FOR OPTICAL PATIENT SENSORS - The present embodiments relate generally to patient monitoring system and, more particularly, to optical patient monitoring systems. In an embodiment, a physiological sensor includes a broadband emitter configured to emit two or more wavelengths of light into the tissue of a patient. The sensor also includes a charge coupled device (CCD) or complementary metal-oxide semiconductor (CMOS) photodetector array comprising a plurality of photodetectors. Each photodetector in the photodetector array is configured to receive the light from the tissue of the patient and to produce a corresponding output signal. Additionally, the sensor also includes one or more filter layers disposed on the plurality of photodetectors. The filter layers are configured to only allow light of particular wavelengths, polarizations, or both, to be received by each of the plurality of photodetectors.03-07-2013
20080200780OPTICAL MEASUREMENT OF CELLULAR ENERGETICS - This document discloses, among other things, systems and methods for measuring a level of myoglobin, hemoglobin, and cytochrome using an optical probe coupled to a spectrometer. Multivariate analysis of the spectral data yields quantifiable cellular and mitochondrial characteristics.08-21-2008
20090270698BIOINFORMATION MEASUREMENT DEVICE - A bioinformation measurement device that enables further accurate bioinformation measurement is provided. The device includes an insertion portion 10-29-2009
20130066172Device and Method for Detecting and Monitoring Ingredients or Properties of a Measurement Medium, In Particular of Physiological Blood Values - The invention relates to a device for detecting and monitoring ingredients or properties of a measurement medium, for example physiological blood values, wherein said device contains a light source (03-14-2013
20110046459Non-Invasive Patient Monitoring Using Near Infrared Spectrophotometry - Methods, systems, and related computer program products for non-invasive spectrophotometric monitoring of an optical property of a medium are described. Respective light portions are propagated through respective at least partially non-overlapping subregions of the medium during each of a calibration interval and a subsequent monitoring interval. Detections of the light portions acquired during the calibration interval are processed to compute at least one algorithm compensation that causes a first result related to the optical property for the first subregion to be substantially equal to a second result related to the optical property for the second subregion. Subsequently, detections of respective light portions acquired during the monitoring interval are processed in conjunction with the at least one algorithm compensation to compute a monitoring result for the optical property. Advantages can include a reduction in the number of sources/detectors required and/or an obviation of symmetry requirements in source/detector layout.02-24-2011
20090234204Methods for Noninvasive Determination of in vivo Alcohol Concentration using Raman Spectroscopy - Methods and apparatuses for the determination of an attribute of the tissue of an individual use non-invasive Raman spectroscopy. For example, the alcohol concentration in the blood or tissue of an individual can be determined non-invasively. A portion of the tissue is illuminated with light, the light propagates into the tissue where it is Raman scattered within the tissue. The Raman scattered light is then detected and can be combined with a model relating Raman spectra to alcohol concentration in order to determine the alcohol concentration in the blood or tissue of the individual. Correction techniques can be used to reduce determination errors due to detection of light other than that from Raman scattering from the alcohol in the tissue. Other biologic information can be used in combination with the Raman spectral properties to aid in the determination of alcohol concentration, for example age of the individual, height of the individual, weight of the individual, medical history of the individual and his/her family, ethnicity, skin melanin content, or a combination thereof. The method and apparatus can be highly optimized to provide reproducible and, preferably, uniform radiance of the tissue, low tissue sampling error, depth targeting of the tissue layers or sample locations that contain the attribute of interest, efficient collection of Raman spectra from the tissue, high optical throughput, high photometric accuracy, large dynamic range, excellent thermal stability, effective calibration maintenance, effective calibration transfer, built-in quality control, and ease-of-use.09-17-2009
20100081897Transmission Mode Photon Density Wave System And Method - Present embodiments are directed to a monitor system, such as a pulse oximetry system. The system may include a detection feature, an emission feature capable of emitting light into tissue and arranged relative to the detection feature such that the detection feature is capable of detecting the light from the tissue after passing generally through a portion of the tissue, a modulator capable of modulating the light to generate photon density waves at a modulation frequency generally in a range of 50 MHz to 3 GHz, a detector communicatively coupled with the detection feature, wherein the detector is capable of detecting characteristics of the photon density waves comprising amplitude changes and phase shifts, and a processor capable of making determinations relating to a value of a physiologic parameter of the tissue based at least in part on the detected characteristics.04-01-2010
20120238840SUBSTANCE COMPONENT DETECTION DEVICE - A substance component detection device includes a sensor substrate which is provided inside a concave groove, in which when an opening is closed by a measurement-target skin to form a closed space, and includes a projection group having a plurality of projections, a light source section which emits light toward the projection group, and light-receiving section which detects Raman scattering light generated by the projection group.09-20-2012
20120238839System, devices, and methods for real-time monitoring of cerebrospinal fluid for markers of progressive conditions - Systems, devices, methods, and compositions are described for providing real-time monitoring of cerebrospinal fluid for markers of progressive conditions.09-20-2012
20120238837System, devices, and methods for real-time monitoring of cerebrospinal fluid for markers of progressive conditions - Systems, devices, methods, and compositions are described for providing real-time monitoring of cerebrospinal fluid for markers of progressive conditions.09-20-2012
20100228108CONFIGURABLE PHYSIOLOGICAL MEASUREMENT SYSTEM - A physiological measurement system has a sensor, a processor, a communications link and information elements. The sensor is configured to transmit light having a plurality of wavelengths into a tissue site and to generate a sensor signal responsive to the transmitted light after tissue attenuation. The attenuated light can be used by the system to determine a plurality of physiological measurements. The processor is configured to operate on the sensor signal so as to derive at least one physiological parameter after which of the plurality of physiological measurements the system is configured to or capable of measuring.09-09-2010
20120232362BODILY FLUID COMPOSITION ANALYZER WITH DISPOSABLE CASSETTE - Disclosed is an apparatus for analyzing the composition of bodily fluid. The apparatus can include a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid in a patient and a pump unit in operative engagement with the fluid handling network. The pump unit can have an infusion mode, in which the pump unit is operable to deliver infusion fluid to the patient through the patient end, and a sample draw mode, in which the pump unit is operable to draw a sample of the bodily fluid from the patient through the patient end. The apparatus can include a spectroscopic analyzer positioned to analyze at least a portion of the sample; a processor in communication with or incorporated into the spectroscopic analyzer; and stored program instructions executable by the processor to obtain measurements of two or more properties of the sample.09-13-2012
20110275913DEVICE FOR MEASURING AT LEAST ONE PARAMETER OF AN ARTERIAL BLOOD SAMPLE - The invention relates to a device for measuring at least one parameter of an arterial blood sample, including a flow sensor having standardized connecting elements which are connected to the inlet and the outlet side of a measuring cell of the flow sensor, the measuring cell having at least one optochemical sensor element which can be brought in contact with the blood sample. A connector is removably placed on the flow sensor and includes at least one light source for exciting the optochemical sensor element and at least one photodetector for receiving the measurement radiation of the optochemical sensor element. An electronic module has an electric connecting line to the connector and contacts the at least one light source and the at least one photodetector, the flow sensor being connectible to the standardized connection of an arterial catheter via the connecting element on the inlet side and to the standardized connection of an arterial infusion set via the connection on the outlet side.11-10-2011
20120108924SYSTEM AND METHOD FOR DETECTION OF SKIN WOUNDS AND COMPARTMENT SYNDROMES - A system configured to provide feedback regarding fluid parameters in the skin and/or compartments of an individual to facilitate early diagnosis of skin wounds and compartment syndromes.05-03-2012
20110295092Biologic Information Detecting Apparatus - In measurement requiring application of pressure to a tissue of a living body such as blood pressure measurement, noise due to vibration tends to occur. It is therefore difficult to accurately measure a pulse wave and a blood pressure value, and there is a problem of measuring blood pressure stably. It is also difficult to measure blood pressure in daily life activities or to measure blood pressure at predetermined intervals or continuously in a state where a tonometer is always attached. There is consequently a problem of providing a method of holding a biologic information detecting apparatus. The present invention has been achieved to solve the problems and an object of the invention is to provide an easy-to-wear biologic information detecting apparatus for stably detecting biologic information.12-01-2011
20100249547VITRO DETERMINATION OF ANALYTE LEVELS WITHIN BODY FLUIDS - A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.09-30-2010
20100030039MULTI-STREAM SENSOR FRONT ENDS FOR NONINVASIVE MEASUREMENT OF BLOOD CONSTITUENTS - The present disclosure relates to an interface for a noninvasive glucose sensor that comprises a front-end adapted to receive an input signals from optical detectors and provide corresponding digital signals. In one embodiment, the front-end comprises switched capacitor circuits that are capable of handling multiple streams signals from the optical detectors. In another embodiment, the front-end comprises transimpedance amplifiers that are capable of handling multiple streams of input signals. In this embodiment, the transimpedance amplifier may be configured based on its own characteristics, such as its impedance, the impedance of the photodiodes to which it is coupled, and the number of photodiodes to which it is coupled.02-04-2010
20090247841LANCET WITH CAPILLARY CHANNEL - The invention relates to a lancet having a lancet body with a lancet tip for creating a puncture wound and a capillary channel to convey body fluids out of the puncture wound in a direction of conveyance. The capillary channel is formed by a slot which runs through the entire lancet body perpendicular to the direction of conveyance, and a test area for optically inspecting a body fluid sample which is conveyed by the capillary channel. The test area is constructed as a section of the slot and has a transparent component with a moistening surface for moistening with a body fluid sample for inspection. The invention further relates to a pricking system comprising such a lancet and a pricking device for creating a puncture wound.10-01-2009
20100022857MAGNETICALLY CONTROLLED WIRELESS OPTICAL OXYGEN SENSOR FOR INTRAOCULAR MEASUREMENTS - A sensor for intraocular measurements moveable within at least one of an vitreous humor of an eye, an aqueous humor of an eye and an intraocular replacement medium. The sensor includes a magnetic body susceptible to magnetic fields and at least one sensor film.01-28-2010
20100063369OPTICAL BIOLOGICAL INFORMATION MEASURING APPARATUS, OPTICAL BIOLOGICAL INFORMATION MEASURING METHOD, BIOLOGICAL INFORMATION DECISION APPARATUS, PROGRAM AND RECORDING MEDIUM - An optical biological information measuring apparatus includes a measuring surface to be placed on the surface of a living body, a mark display section which displays a mark at a region to be measured on the surface of the living body, a light-emitting section which irradiates the living body with light of a predetermined wavelength and a light-receiving section which receives light irradiated onto the living body and returned from the living body, and measures information on the living body based on the received light. The optical biological information measuring apparatus is capable of measuring biological information with improved alignment accuracy.03-11-2010
20100113899Alignment System for Optically Sampling a Hand - This invention relates to measurements of material properties by determination of the response of a sample to incident radiation, and more specifically to the measurement of analytes such as glucose or alcohol in human tissue. Some example embodiments of the present invention provide an optical sampling apparatus including an optical subsystem, having a receiver for receiving light expressed from tissue; and an alignment subsystem, adapted to urge a portion of a hand placed in operative relationship with the alignment subsystem into a defined configuration relative to the receiver. In some such example embodiments, the alignment subsystem includes a substrate having a plurality of projections therefrom disposed in a pattern such that the projections urge a portion of a hand placed on the substrate to a defined configuration relative to the receiver. In some such example embodiments, the alignment subsystem includes a substrate having a surface defining a volume approximating the shape of a portion of a hand such that the volume urges a portion of a hand placed therein to a defined configuration relative to the receiver. In some such example embodiments, the alignment subsystem includes a surface having a generally U-shaped cross-section and extending for a distance, wherein the surface is mounted relative to the sampling means such that a finger placed in the U-shaped cross-section of the surface is urged to a defined configuration relative to the receiver. In some such sample embodiments, the alignment subsystem is customized to portion of the hand of a specific individual.05-06-2010
20090318785REAL - TIME SIMULTANEOUS MEASUREMENT SYSTEM, REAL - TIME SIMULTANEOUS MEASUREMENT APPARATUS, REAL-TIME SIMULTANEOUS MEASUREMENT METHOD, AND STORAGE MEDIUM IN WHICH PROGRAM IS STORED - A real-time simultaneous measurement apparatus includes: a hemoglobin information-receiving portion that sequentially receives hemoglobin information, which is information relating to the amount of hemoglobin in a head portion of a test subject, from a NIRS brain-measuring apparatus that receives a synchronization signal output by a synchronization signal output apparatus and acquires the hemoglobin information when the synchronization signal has been received; a brain wave information-receiving portion that sequentially receives the brain wave information of the test subject, from an EEG brain wave-measuring apparatus that receives a synchronization signal output by the synchronization signal output apparatus and acquires the brain wave information when the synchronization signal has been received; a synchronization processing portion that performs processing that synchronizes the hemoglobin information and the brain wave information; and an output portion that outputs the synchronized hemoglobin information and brain wave information.12-24-2009
20120108923SYMMETRICALLY PACKAGED OPTICAL SENSORS FOR IMPLANTABLE MEDICAL DEVICES - Implantable medical devices and methods include an optical sensor that includes at least two optical sensor portions. The light emitting devices of the optical sensor are distributed among the at least two optical sensor portions.05-03-2012
20100087717BIO-INFORMATION MEASURING APPARATUS - A bio-information measuring apparatus is provided, which suppresses pressure on a capillary vessel of body, stabilizes a measuring result of bio-information, and obtains a good S/N ratio.04-08-2010
20130046154PPG IMAGING DEVICE AND PPG MEASURING METHOD - The present invention discloses a PPG imaging device and a PPG measuring method. The PPG imaging device comprises a light emitting unit, a collimator unit, a beam splitter unit, an image sensing unit, and an image analysis unit. The light emitting unit provides an incident light signal. The collimator unit receives the incident light signal and transforms the incident light signal into a parallel light signal. The beam splitter unit receives the parallel light signal and reflects it to a tested region. The image sensing unit receives a reflected light signal reflected from the tested region and converts it into image signals. The image analysis unit connects with the image sensing unit and analyzes the image signals to obtain PPG signals of the tested region. The PPG imaging device may be arranged in an anti-light pollution unit, whereby to prevent from optical interference and obtain higher measurement precision.02-21-2013
20090275813EXTERNAL EAR-PLACED NON-INVASIVE PHYSIOLOGICAL SENSOR - In one embodiment, a non-invasive physiological sensor assembly is capable of attachment to a tissue site of the ear comprising of cartilaginous structures of the ear, providing low latency of physiological measurements as well as a secure attachment.11-05-2009
20090275812Flowometry in Optical Coherence Tomography for Analyte Level Estimation - Optical coherence tomography (herein “OCT”) based analyte monitoring systems are disclosed. In one aspect, techniques are disclosed that can identify fluid flow in vivo (e.g., blood flow), which can act as a metric for gauging the extent of blood perfusion in tissue. For instance, if OCT is to be used to estimate the level of an analyte (e.g., glucose) in tissue, a measure of the extent of blood flow can potentially indicate the presence of an analyte correlating region, which would be suitable for analyte level estimation with OCT. Another aspect is related to systems and methods for scanning multiple regions. An optical beam is moved across the surface of the tissue in two distinct manners. The first can be a coarse scan, moving the beam to provide distinct scanning positions on the skin. The second can be a fine scan where the beam is applied for more detailed analysis.11-05-2009
20090043178Optical non-invasive blood monitoring system and method - A simple noninvasive technique that is capable of very accurate and fast blood analyte, e.g., glucose, level monitoring is provided. Fluctuation in the levels of glucose and other analytes affect the refractive index of blood and extra cellular fluid in biological tissue. Given that the propagation speed of light through a medium depends on its refractive index, continuous monitoring of analyte levels in tissue is achieved by measuring characteristics of the tissue that can be correlated to the refractive index of the tissue. For instance, the frequency or number of optical pulse circulations that are transmitted through an individual's tissue of known thickness within a certain time period can be correlated to an individual's blood glucose level.02-12-2009
20110172509Examination of biological tissue using non-contact optical probes - An optical system for examination of biological tissue includes a light source, a light detector, optics and electronics. The light source generates a light beam to be transmitted to the biological tissue spaced apart from the source. The light detector is located away (i.e., in a non-contact position) from the examined biological tissue and is constructed to detect light that has migrated in the examined biological tissue. The electronics controls the light source and the light detector, and a system separates the reflected photons (e.g., directly reflected or scattered from the surface or superficial photons, i.e., “noise” photons) from the photons that have migrated in the examined biological tissue. This system prevents detection of the “noise” photons by the light detector or, after detection, eliminates the “noise” photons in the detected optical data used for tissue examination.07-14-2011
20120296179ANALYTE CONCENTRATION DETECTION DEVICES AND METHODS - Arrangements for the detection of the presence and/or concentration of an analyte in a sample of bodily fluid include diffuse transmission, diffuse reflection and edge or waveguide illumination arrangements. A vertical flow assay arrangement and/or technique is also disclosed, and includes a detection component that can be in the form of an array of optical detection elements. A number of assay pad constructions are described which may include at least one or more of the following components: a prefilter component, a reflective component, a membrane component, a reagent component, a mesh component, and a component to prevent lateral spreading.11-22-2012
20110208023Systems, devices, and methods including implantable devices with anti-microbial properties - Systems, devices, methods, and compositions are described for providing an actively controllable implant configured to, for example, monitor, treat, or prevent microbial growth or adherence to the implant.08-25-2011
20080275317Medical Measuring Device - The invention relates to a measuring device (11-06-2008
20080249380Protection Mechanism for Spectroscopic Analysis of Biological Tissue - The present invention provides a protection mechanism for a spectroscopic analysis system being adapted to determine a property of a biological structure in a volume of interest of a patient. The spectroscopic system preferably makes use of high power radiation, and provides a protection mechanism for preventing an accidental exposure of light sensitive tissue of a body. The invention provides a variety of approaches to detect whether a measurement head of the spectroscopic system is in a measurement position. The measurement position of the measurement head can effectively be determined by making use of e.g. a pressure sensor, a sensor measuring the electric resistance of the skin of the patient, or even by optical means analyzing the intensity or the spatial structure of a monitoring beam providing a visual image of the volume of interest.10-09-2008
20120296178PERSONAL HEALTH DEVICE - An active pulse blood constituent monitor is disclosed. A sensor configured to provide an artificial excitation to a portion of the patient at a known frequency provides additional information in determining the physiological condition of the patient.11-22-2012
20110009719MULTIPLE WAVELENGTH SENSOR SUBSTRATE - A physiological sensor has emitters configured to transmit optical radiation having multiple wavelengths in response to corresponding drive currents. A thermal mass is disposed proximate the emitters so as to stabilize a bulk temperature for the emitters. A temperature sensor is thermally coupled to the thermal mass. The temperature sensor provides a temperature sensor output responsive to the bulk temperature so that the wavelengths are determinable as a function of the drive currents and the bulk temperature.01-13-2011
20090264718IMPLANTED SENSOR PROCESSING SYSTEM AND METHOD FOR PROCESSING IMPLANTED SENSOR OUTPUT - A quantitative measurement system includes an external unit and an internal unit are provided for obtaining quantitative analyte measurements, such as within the body. In one example of an application of the system, the internal unit would be implanted either subcutaneously or otherwise within the body of a subject. The internal unit contains optoelectronics circuitry, a component of which may be comprised of a fluorescence sensing device. The optoelectronics circuitry obtains quantitative measurement information and modifies a load as a function of the obtained information. The load in turn varies the amount of current through coil, which is coupled to a coil of the external unit. A demodulator detects the current variations induced in the external coil by the internal coil coupled thereto, and applies the detected signal to processing circuitry, such as a pulse counter and computer interface, for processing the signal into computer-readable format for inputting to a computer.10-22-2009
20090177052Methods of using raman spectral information in determining analyte concentrations - A non-invasive method of determining the concentration of an analyte uses Raman spectral information. A high-intensity, narrow band of light (07-09-2009
20090187084Flexible Carbohydrate-Bearing Polymer - A sensor for the detection or measurement of a carbohydrate analyte in fluid comprises components of a competitive binding assay the readout of which is a detectable or measurable optical signal retained by a material that permits diffusion of the analyte but not the assay components, the assay components comprising: a carbohydrate binding molecule labelled with one of a proximity based signal generating/modulating moiety pair; and a carbohydrate analogue capable of competing with the analyte for binding to the carbohydrate binding molecule, the carbohydrate analogue being a flexible water-soluble polymer comprising: polymerized or co-polymerised residues of monomer units, the monomer unit residues bearing pendant carbohydrate or carbohydrate mimetic moieties and pendant moieties which are the other of the proximity based signal generating/modulating moiety pair.07-23-2009
20090005659Tissue Ablation by Shear Force for Sampling Biological Fluids and Delivering Active Agents - A shear device for use in transporting a molecule through a mammal's mammalian barrier membrane of at least one layer of cells includes a sheet containing an opening(s) and a shear member(s). The sheet is configured for contacting the mammalian barrier membrane (e.g., human skin) and the shear member is configured for ablating a portion of the mammalian barrier membrane forced through the opening(s). This ablating is accomplished by movement of the shear member(s) over the sheet and the opening(s). The ablation of the portion of the mammalian barrier membrane is such that a driving force can be employed to transport the molecule therethrough.01-01-2009
20110144459LIQUID CONCENTRATION DETECTOR FOR A BLOOD PURIFICATION APPARATUS - A blood purification apparatus includes a blood purification instrument for extracorporeally circulating blood of a patient and a concentration detector detecting a concentration of liquid flowing during blood purification. The concentration detector has a light emitter irradiating light onto said liquid, a light receiver receiving light from the light emitter transmitted through said liquid, and a detector detecting the received light intensity received by the light receiver. The concentration detector detects the concentration of the liquid based on the received light intensity and can be calibrated by adjusting an amount of irradiation by the light emitter so that the received light intensity has a predetermined value.06-16-2011
20080319286Optical Probes for Non-Invasive Analyte Measurements - An optical probe for non-invasively measuring an analyte property in a biological sample of a subject, comprises a plurality of illumination fibers that deliver source light from an optical probe input to a sample interface, a plurality of collection fibers that deliver light returned from the sample interface to an optical probe output, and wherein the illumination and collection fibers are oriented substantially perpendicular to the sample interface and the illumination and collection fibers are stacked in a plurality of linear rows to provide a stack of fibers arranged in a rectangular pattern. The optical probe is amenable to manufacturing on a scale consistent with a commercial product.12-25-2008
20080306363Specialized Human Servo Device And Process For Tissue Modulation Of Human Fingerprints - Apparatus and methods for noninvasive spectroscopic measurement of an analyte in a subject that have been optimized for producing uniform and repeatable tissue modulation across test subjects and for the same test subject on different occasions are provided. The apparatus comprises an ergonomically shaped grip that substantially conforms to a subject's hand; a surface for placement of at least one of the subject's fingertips upon grasping the grip; and an optically transparent aperture, or a plurality of apertures, disposed within the surface. A modification to the surface of the apparatus adjacent to the aperture that is detectable via the tactile sense of the subject can be added to provide tactile feedback to the subject to guide correct placement of the fingertip over the aperture. The apparatus and methods can also incorporate feedback methods to guide and optimize placement and conditions of the fingertip to further improve accuracy of measurements.12-11-2008
20090198113DEDICATED SPECTRAL ILLUMINATION SPECTROSCOPY - Apparatus and method for an analyte determination in blood, relying on spectroscopic techniques, in which sample is illuminated with light having dedicated spectral characteristics. The first light source (08-06-2009
20090082649ACCESS DISCONNECT SYSTEM WITH OPTICAL AND OTHER SENSORS - An optical access disconnect system is useful for detecting the presence of blood. The optical access disconnect system includes one or more optical sensors placed near an access site of a patient, the optical sensors suitable for detecting the presence of blood, especially by detecting a difference in light reflected or absorbed by blood. The optical access disconnect system may also be used as an interlock to assure compliance. A detector may be placed adjacent the access site to detect the access needle, or an object or mark on the access needle or fluid line. A therapy machine, such as a dialysis machine, may be programmed not to start or continue operation unless the needle or fluid line is detected. The detector may be one of the optical sensors, calibrated or adjusted to detect a mark on the needle or access line, or may be another type of detector.03-26-2009
20110224514Implantable Sensor Element - The invention relates to a sensor element (09-15-2011
20110224512INTRACELLULAR pH IMAGING METHOD AND APPARATUS USING FLURESCENCE LIFETIME - In a pH measurement method, pulsed excitation light including a wavelength that can excite a predetermined fluorescent material contained in living matter is generated. The fluorescent material acts as coenzyme in oxidation/reduction reaction in vivo. Further, the intensity of the pulsed excitation light does not damage a tissue nor a cell in the living matter, and does not substantially change the pH of the living matter. Further, a predetermined position in the living matter is illuminated with the pulsed excitation light, and light including fluorescence emitted from the fluorescent material excited by illumination with the pulsed excitation light is received. The lifetime of the fluorescence is calculated by time-resolving the intensity of the received fluorescence, and the pH of the living matter is measured based on the lifetime.09-15-2011
20110230738Optical examination of biological tissue using non-contact irradiation and detection - An optical system for examination of biological tissue includes a light source, a light detector, optics and electronics. The light source generates a light beam, transmitted to the biological tissue, spaced apart from the source. The light detector is located away (i.e., in a non-contact position) from the examined biological tissue and is constructed to detect light that has migrated in the examined tissue. The electronics controls the light source and the light detector, and a system separates the reflected photons (e.g., directly reflected or scattered from the surface or superficial photons) from the photons that have migrated in the examined tissue. The system prevents detection of the “noise” photons by the light detector or, after detection, eliminates the “noise” photons in the detected optical data used for tissue examination.09-22-2011
20090187085System And Method For Estimating Physiological Parameters By Deconvolving Artifacts - There is disclosed a system and methods to estimate physiological parameters. In accordance with embodiments a method is disclosed which includes generating distribution data for a plurality of signals. The method may also include deconvolving one of the plurality of signals from the other plurality of signals to produce clean signals. The clean signals may then be used to calculate physiological parameters.07-23-2009
20080262324Measurement Head For Non-Invasive Blood Analysis - The present invention provides an efficient approach of attaching and fixing a measurement head for a spectroscopic system to a variety of different parts of the skin of a patient. The measurement head preferably features a compact design providing a flexible handling and offering a huge variety of application areas taking into account the plurality of properties of various portions of the skin. Furthermore, the measurement head features a robust and uncomplicated optical design not requiring a lateral shifting of the optical axis of the objective. Such transverse relative movements between the objective and a capillary vessel in the skin are preferably performed by mechanically shifting the skin with respect to the objective of the measurement head. Moreover, the measurement head is adapted to host one or more pressure sensors measuring the contact pressure between the measurement head and the skin. This pressure information can further be exploited in order to calibrate the spectroscopic analysis means, to regulate the contact pressure within predefined margins specifying an optimum range of contact pressure for spectroscopic examination of capillary vessels.10-23-2008
20090105564LIVING BODY COMPONENT MEASURING APPARATUS CAPABLE OF PRECISELY AND NON-INVASIVELY MEASURING LIVING BODY COMPONENT - A living body component measuring apparatus emits light of a first wavelength being specific to a measuring target component from a light emitting unit (04-23-2009
20090247840METHOD AND APPARATUS FOR COUPLING A SAMPLE PROBE WITH A SAMPLE SITE - The invention comprises method and apparatus for fluid delivery between a sample probe and a sample. The fluid delivery system includes: a fluid reservoir, a delivery channel, a manifold or plenum, a channel or moat, a groove, and/or a dendritic pathway to deliver a thin and distributed layer of a fluid to a sample probe head and/or to a sample site. The fluid delivery system reduces sampling errors due to mechanical tissue distortion, specular reflectance, probe placement, and/or mechanically induced sample site stress/strain associated with optical sampling of the sample.10-01-2009
20090247839PROBE DEVICE - In a probe device including a light irradiating portion irradiating a light to a surface of a living body, and a light detecting portion detecting the light passing through an inner portion of the living body so as to emit from the surface of the living body, the probe device is provided with a sheet-like probe holding body, a plurality of light emitting probes and a plurality of detection probes which are attached to the probe holding body at a predetermined interval, a board holding portion attached to a predetermined position of the probe holding portion, an electronic board attached to the board holding portion, a sheet holding portion holding the probe holding body at a predetermined position of a head portion (a tested position) of the test subject, and a fixing band portion for installing the sheet holding portion to the test subject10-01-2009
20100274109MEASUREMENT APPARATUS FOR HEART RATE VARIABILITY - The present invention relates to a measurement apparatus for heart rate variability, which comprises an earpiece, a measurement module for photoplethysmographic (PPG) signal measuring an ear and producing a first physiological signal of a person under test, a measurement module for electrocardiographic (ECG) signal measuring a second physiological signal of the person under test, and a control and processing unit transmitting a sound signal to the earpiece. By playing the sound signal from the earpiece, the attention of the person under test can be detracted from the measurement module for PPG signal or the measurement module for ECG signal. Thereby, nervousness and impatience of the person under test can be eliminated, and hence the real heart rate variability of the person under test can be measured.10-28-2010
20090259114NON-INVASIVE OPTICAL SENSOR - An apparatus includes a sensor body, a circuit board, a cable, at least one light emitting device, and at least one photodetector. The circuit board is enclosed within the sensor body and includes at least one conductive trace and at least one aperture. The cable is coupled to the at least one conductive trace. The cable includes a shield conductor and a signal conductor. The at least one light emitting device is coupled to the circuit board and is configured to emit light into a tissue. The at least one photodetector includes a planar active area coupled to the circuit board and is configured to provide an output signal based on light detected by the active area. The planar active area is aligned with the aperture. The output signal is coupled to the cable.10-15-2009
20110060198Multi-Parametric Fluid Determination Systems Using Complex Admittance - Apparatus, systems, and methods related to determining the identity and concentration of an intravenous fluid. The apparatus, systems, and methods described herein may provide near real-time monitoring and/or determination of the identity of the components of an intravenous fluid. The concentration and identify of all of the components of an intravenous fluid may be identified simultaneously.03-10-2011
20110060197NEAR INFRARED SPECTROPHOTOMETRY WITH ENHANCED SIGNAL TO NOISE PERFORMANCE - Methods, systems, and related computer program products for the non-invasive spectrophotometric monitoring of an optical property of a tissue volume are described. Multiple optical signals having different modulation frequencies are introduced into the tissue volume simultaneously and on a continuous basis throughout the monitoring session. Multiple optical signal portions incident upon each of a plurality of optical detectors are detected and separated based on their modulation frequency. Amplitude and phase signals corresponding to each optical signal portion are extracted and processed to determine the optical property of the tissue volume. In one preferred embodiment, a first optical detector includes an aperture having a central area, a first edge positioned nearer to a first optical source than the central area, and a second edge positioned farther from the first optical source than the central area. The first and second edges are each curved concavely toward the first optical source.03-10-2011
20100217102Light-Guiding Devices and Monitoring Devices Incorporating Same - A monitoring device configured to be attached to the ear of a person includes a base, an earbud housing extending outwardly from the base that is configured to be positioned within an ear of a subject, and a cover surrounding the earbud housing. The base includes a speaker, an optical emitter, and an optical detector. The cover includes light transmissive material that is in optical communication with the optical emitter and the optical detector and serves as a light guide to deliver light from the optical emitter into the ear canal of the subject wearing the device at one or more predetermined locations and to collect light external to the earbud housing and deliver the collected light to the optical detector.08-26-2010
20100234703METHOD AND APPARATUS FOR DETECTION OF MULTIPLE ANALYTES - In some embodiments, an apparatus analyzes the composition of bodily fluid. The apparatus comprises a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid in a patient and at least one pump intermittently operable to draw a sample of bodily fluid from the patient. The apparatus further comprises a fluid analyzer positioned to analyze at least a portion of the sample and measure the presence of two or more analytes. Also disclosed is a method for analyzing the composition of a bodily fluid in a patient. The method comprises drawing a sample of the bodily fluid of the patient through a fluid handling network configured to maintain fluid communication with a bodily fluid in a patient. The method further comprises analyzing the at least a portion of the sample in a fluid analyzer to estimate the concentration of two or more analytes in the sample.09-16-2010
20090076353IMPLANTABLE ELECTRO-OPTICAL SENSOR - Embodiments of the invention are related to electro-optical implantable sensors, amongst other things. In an embodiment, the invention includes an implantable medical device including a housing defining an interior volume, the housing comprising a housing wall and defining an aperture. The implantable medical device can include an optical sensor assembly coupled to the housing wall. The optical sensor assembly can occlude the aperture in the housing wall. The optical sensor assembly can include an electro-optical module including an optical excitation assembly and an optical detection assembly. The optical sensor assembly can also include a chemical sensing element configured to detect a physiological analyte by exhibiting a change in optical properties. An optical window can be disposed between the electro-optical module and the chemical sensing element. The optical window can be configured to allow the transmission of light between the electro-optical module and the chemical sensing element. Other embodiments are also included herein.03-19-2009
20100222655APPARATUS AND METHOD FOR MONITORING PRESSURE RELATED CHANGES IN THE EXTRA-THORACIC ARTERIAL CIRCULATORY SYSTEM - A method and apparatus for monitoring changes in the intra-thoracic pressure of a patient due to the patient's respiratory activity or volumetric changes in the extra-thoracic arterial circulatory system due to cardiac function based on the changes in pressure in the patient's extra-thoracic arterial circulatory system as measured by a plethysmography sensor, such as an photoplethysmograph. A frequency spectrum is generated for the plethysmograph signal and the frequencies of interest is isolated from the frequency spectrum by setting appropriate cutoff frequencies for the frequency spectrum. This isolated frequency is used to filter the plethysmograph signal to provide a signal indicative of the patient's respiratory activity or cardiac function.09-02-2010
20100210925Optical Apparatus for Measuring a Physiological Property of a Body Part and Method Therefore - An optical measurement apparatus comprises an optical system (08-19-2010
20100210926Apparatus and Method for Detecting at Least One Vital Parameter of a Person; Vital Parameter Detection System - What is described is an apparatus for detecting at least one vital parameter of a person, including: an optoelectronic sensor arrangement for detecting the at least one vital parameter by means of light transmission or light remission, the optoelectronic sensor arrangement including a light source and a light-sensitive element, wherein for detecting the vital parameter by means of light transmission, the light source is arranged in a first side part of a support frame of a pair of spectacles, and the light-sensitive element is arranged in a second side part of the support frame which is opposite the first side part, and wherein for detecting the at least one vital parameter by means of light remission, the light source and the light-sensitive element are arranged in the same side part of the support frame of the pair of spectacles.08-19-2010
20100222656METHODS AND APPARATUS FOR SAMPLING AND ANALYZING BODY FLUID - A sampling device for sampling body fluid includes a lancet for making an incision, a capillary tube for drawing-up body fluid from the incision, and a test strip affixed to an upper end of the capillary tube for receiving the fluid. An absorbent pad can be disposed between the test strip and capillary tube for spreading-out the fluid being transferred to the test strip. An on-site analyzer such as an optical analyzer and/or an electrochemical analyzer can be mounted in the device for analyzing the fluid. Alternatively, a test strip can be slid through a slot formed in the bottom end of the device so that by passing the device against the skin after an incision has been formed, the test strip will directly contact body fluid emanating from the incision.09-02-2010
20090062631Determination of the state of health of a human being - The invention provides a method for the determination of the state of an entity, in particular the state of health of a human being or animal. The method includes the step of contacting secreted compounds or related reaction products with a surface linked to an optical waveguide in such a way that compounds binding to the surface can influence the propagation of light in the waveguide, determining the occurring influence by means of an optical interferometric measuring principle, and deducing the state from the occurring influence. The invention further provides a device for the determination of such a state.03-05-2009
20090036759COLLAPSIBLE NONINVASIVE ANALYZER METHOD AND APPARATUS - The invention relates generally to a noninvasive spectroscopic based analyzer. More particularly, a collapsible spectrometer and or deployable subject interface for an analyzer, such as a noninvasive glucose concentration analyzer, is described.02-05-2009
20100331636METHOD FOR THE CONTINUOUS NON-INVASIVE DETERMINATION OF THE CONCENTRATION OF BLOOD CONSTITUENTS - The invention relates to a method for the non-invasive determination of the concentration of blood constituents, in which a radiation source (12-30-2010
20110009718DETERMINATION OF PHYSIOLOGICAL PARAMETERS USING REPEATED BLOOD PRESSURE MEASUREMENTS - A pulsewave detection unit is provided, at least a portion of the pulsewave detection unit being configured to be coupled to a portion of a subject's body, the pulsewave detection unit generating a signal that is responsive to arterial pressure of the portion of the subject's body. A pulsewave parameters determination unit receives respective first and second signals from the pulsewave detection unit, the signals being responsive to arterial pressure of the portion of the subject's body while the portion of the pulsewave detection unit that is coupled to the portion of the subject's body is at respective first and second heights, at respective times. An arterial parameters calculating unit determines an arterial property of the subject by processing the first and second signals, and generates an output in response to determining the arterial property. Other embodiments are also described.01-13-2011
20110124989Handheld Apparatus And Method For The Automated Application Of Cosmetics And Other Substances - An applicator head is provided for a reflectance modifying agent (RMA) applicator is moved across the skin by means of a floating ring having dispersed raised contact points to maintain a proper distance from the surface to be treated, reduce the influence of outside light during scanning, and limit smudging during deposition. During an application session, software on the computer uses a camera to sense aspects of color and texture on human features, calculates cosmetic enhancements, and uses the printer head to apply RMA precisely to the features to create those enhancements. Skin landmarks are used for registration. The head uses differential lighting by providing a sequence of directional lighting, with some exposures left dark to adjust for ambient light leakage. The exposures are co-synchronized in stacks, where each stack is a grouping of data about a particular instant of time during the scanning.05-26-2011
20110124988METHOD AND APPARATUS FOR ANALYSIS OF TURBID MEDIA VIA SINGLE-ELEMENT DETECTION USING STRUCTURED ILLUMINATION - Method and apparatus for obtaining qualitative and quantitative analysis of the optical properties or structures of tissue or turbid medium at one or more wavelengths via 1) detection at a single spatial location on the surface of a turbid medium (such as tissue) under two or more structured light conditions or 2) detection at two or more spatial locations on the surface under a single structured light condition.05-26-2011
20110245637AMBIENT LIGHT USE IN PHYSIOLOGICAL SENSORS - The present disclosure describes the harvesting and use of ambient light in spectrophotometric systems so as to increase the energy efficiency of the systems. In one embodiment, the collected ambient light is filtered and/or converted into discrete wavelengths of light that can then be used in spectrophotometric applications. In one embodiment, the emitted light can then be collected and analyzed to derive various physiological parameters. In certain embodiments, the ambient light may be used in place of light that is electrically generated.10-06-2011
20110152646NONINVASIVE DETECTION OF A PHYSIOLOGIC PARAMETER WITH A PROBE - The invention provides a device for contacting a surface of a patient's body to determine a physiologic parameter in a measurement region of a tissue of the patient. The device typically comprises a sensor responsive to the physiologic parameter and a probe housing the sensor. The probe is constructed to allow the sensor to be secured at a sensing site adjacent to the measurement region, without disturbing the blood flow within the measurement region of the tissue. The device may also include a means for reducing interference in the sensing area. Preferably, the device further comprises an indicating means operably connected to the sensor for indicating an analyte quantity and/or concentration associated with the physiologic parameter.06-23-2011
20120245439METHOD AND APPARATUS FOR DETERMINING CRITICAL CARE PARAMETERS - A physiological measuring system is disclosed that monitors certain physiological parameters of an individual through the use of a body-mounted sensing apparatus. The apparatus is particularly adapted for continuous wear. The system is also adaptable or applicable to calculating derivations of such parameters. A oxygen debt measuring embodiment is directed predicting an outcome in response to injury and illness. The technique allows for closed-loop resuscitation, early identification of illness and early corrective action.09-27-2012
20090216095Arrangement for Providing a Constant Contract Pressure for a Probe - The invention relates to an arrangement for providing a constant contact pressure for a probe to a finger of a patient, including a housing having a top position and a side portion to support said top portion, said top portion having a thickness defined by a top surface and a base of said top portion, said top portion having a bore extending through, the top portion, said bore dimensioned to slidably receive a probe, said probe having a probe tip, a channel extending substantially perpendicular and on a same plane to said bore, said channel sized to receive a finger of a patient, wherein the probe further includes a collar positioned along the probe such that at rest, the collar is in contact with the top surface of the top portion of the housing, and the probe tip extends a distance from the base of the top portion, and into the channel.08-27-2009
20110098542APPARATUS AND METHOD FOR NON-INVASIVE MEASUREMENT OF A SUBSTANCE WITHIN A BODY - A method and apparatus for the noninvasive detection of a concentration of a substance in a body, such as glucose in the human bloodstream is disclosed. The apparatus measures substance concentration by detecting radiation in the far infrared range emitted by the body using an infrared detected in combination with a set of adequate filters. In order to achieve the accuracy required, the radiation values detected by the detector are corrected for the emissions of the system components. The temperature of each system component including the detector temperature and an ambient temperate is determined using temperature sensors attached to the various system components. These temperatures are correlated with a set of predetermined calibration parameters to correct the detector readings.04-28-2011
20100130838Infrared Temperature Measurement of Strip - Provided are systems and methods that permit the direct assessment of temperature on an electrochemical test strip, including at the reaction site of the strip, through the inclusion of an infrared sensor within the biosensing instrument. Analyte measurement systems are provided in which an infrared sensor is used to assess temperature associated with a test strip, and the acquired temperature data is used to modulate data regarding an analyte in a biological sample, thereby providing a more accurate measurement of the analyte.05-27-2010
20110098543METHOD AND APPARATUS FOR REDUCING COUPLING BETWEEN SIGNALS IN A MEASUREMENT SYSTEM - A method and an apparatus for separating a composite signal into a plurality of signals is described. A signal processor receives a composite signal and separates a composite signal in to separate output signals. Feedback from one or more of the output signals is provided to a configuration module that configures the signal processor to improve a quality of the output signals. In one embodiment, the signal processor separates the composite signal by applying a first demodulation scheme to the composite signal to generate a first output signal. In one embodiment, the signal processor also applies a second demodulation scheme to the composite signal to generate a second output signal. In one embodiment, the composite signal is obtained from a detector in a system for measuring one or more blood constituents.04-28-2011
20100069727MEASURING APPARATUS - Provided is a measuring apparatus including: a driving unit that outputs first and second driving signals each having an opposite phase; a first semiconductor laser device, driven by the first driving signal, that emits a first laser beam to an object to be measured; a second semiconductor laser device, disposed near the first device and driven by the second driving signal, that emits a second laser beam to the object; a first detection unit that detects a first electrical signal that corresponds to the intensity of the first laser beam modulated due to the self-coupling effect; a second detection unit that detects a second electrical signal that corresponds to the intensity of the second laser beam modulated due to the self-coupling effect; a calculation unit that calculates differences between the first and second electrical signals; and a measuring unit that measures a state change of the object from the difference.03-18-2010
20110152645PULSE OXIMETRY SENSOR ADAPTER - An adapter allows the interconnection of a sensor originating from one manufacturer to be coupled with conventionally incompatible monitors originating from other manufacturers to form a properly functioning pulse oximetry system. The adapter matches a sensor driver in a monitor to the current requirements and light source configuration of a sensor. The adapter also matches a sensor's light detector signal level to the dynamic range requirements of a monitor preamplifier. Further, the adapter provides compatible sensor calibration, sensor type and security information to a monitor. The adapter may have a self-contained power source or it may derive power from the monitor, allowing both passive and active adapter components. The adapter is particular suited as an adapter cable, replacing a conventional patient cable or sensor cable as the interconnection between a sensor to a monitor in a pulse oximetry system.06-23-2011
20130158372MEDICAL SENSOR FOR USE WITH HEADBAND - Medical sensors configured to provide enhanced patient comfort when worn over a period of time are provided. The medical sensors may include a first padding layer and a second padding layer disposed on either side of an emitter and a detector for measuring a physiological parameter of a patient. The medical sensors may also include an island padding layer secured to a patient-facing side of the second padding layer for reducing localized pressure points that may be caused by protrusions of the sensor. Additionally or alternatively, certain edges of the sensors may be rounded and/or stepped to reduce marking on the patient's tissue and to reduce strain and shear forces produced on the patient's tissue. Still further, certain embodiments provide enhanced light transmission between the emitter and detector of the sensors.06-20-2013
20110082353Implanting Optical Cavity Structures - An implantable product includes an optical cavity structure with first and second parts, each of which can operate as an optical cavity. The first part includes a container with at least one opening through which bodily fluid can transfer between the container's interior and exterior when the product is implanted in a body. The second part includes a container that is closed and contains a reference fluid. The implantable product can also include one or both of a light source component and a photosensing component. Photosensed quantities from the first part's output light can be adjusted based on photosensed quantities from the second part's output light. Both parts can have their light interface surfaces aligned so that they both receive input light from a light source component and both provide output light to a photosensing component.04-07-2011
20110071372Method and System for Providing Basal Profile Modification in Analyte Monitoring and Management Systems - Method and system for providing basal profile modification in insulin therapy for use with infusion devices includes periodically monitoring the analyte levels of a patient for a predetermined period of time in order to determine, based on the monitored analyte levels, an appropriate modification factor to be incorporated into the underlying basal profile which was running at the time the periodic monitoring of the analyte levels were performed.03-24-2011
20110077481Analyte Monitoring Device and Methods of Use - An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.03-31-2011
20090018414Subcutanous Blood Vessels Imaging System - A real time imaging system is described which displays subcutaneous veins whereby facilitating diagnosis, inspection and easy intravenous access for administration of drugs. The imaging system comprises an infrared source (01-15-2009
20120203085NON-INVASIVE SYSTEM AND METHOD FOR MEASURING AN ANALYTE IN THE BODY - A system for determining an analyte concentration in a fluid sample (e.g., glucose) comprises a light source, a detector, and a central processing unit. The detector is adapted to receive spectral information corresponding to light returned from the fluid sample being analyzed and to convert the received spectral information into an electrical signal indicative of the received spectral information. The central processing unit is adapted to compare the electrical signal to an algorithm built upon correlation with the analyte in body fluid. The algorithm is adapted to convert the received spectral information into the analyte concentration in body fluid. Spectral information is delivered from the central processing unit to the light source and used to vary the intensity and timing of the light to improve the accuracy of conversion into analyte concentration.08-09-2012
20080221409System and method for controlling tissue treatment - Embodiments of the present invention relate to a system and method for controlling a tissue treatment device using results from a spectroscopic tissue analyzer. One embodiment provides a system that uses a direct signal from a spectroscopic tissue analyzer to control the tissue treatment device. Alternatively, the system may provide an audible feedback signal to a user, allowing the user to choose how to adjust the tissue treatment device. A final embodiment provides a probe that has active sites for treating tissue, and an optical system to convey light to the active sites, allowing an analysis of the tissue parameter at the active sites.09-11-2008
20110178379TISSUE ASSESSMENT - A method of aiding in the diagnosis or prediction of degenerative joint disease in a joint of a patient. The method comprises obtaining a test spectrum of Raman scattered radiation from cartilage tissue in the joint, and analysing the test spectrum, or one or more regions thereof, to assess whether the test spectrum is consistent with the patient having, or subsequently developing, degenerative joint disease in the joint.07-21-2011
20100004518HEAT SINK FOR NONINVASIVE MEDICAL SENSOR - A noninvasive physiological sensor for measuring one or more physiological parameters of a medical patient can include a bump interposed between a light source and a photodetector. The bump can be placed in contact with body tissue of a patient and thereby reduce a thickness of the body tissue. As a result, an optical pathlength between the light source and the photodetector can be reduced. In addition, the sensor can include a heat sink that can direct heat away from the light source. Moreover, the sensor can include shielding in the optical path between the light source and the photodetector. The shielding can reduce noise received by the photodetector.01-07-2010
20100004519NOISE SHIELDING FOR A NONINVASIVE DEVICE - A noninvasive physiological sensor for measuring one or more physiological parameters of a medical patient can include a bump interposed between a light source and a photodetector. The bump can be placed in contact with body tissue of a patient and thereby reduce a thickness of the body tissue. As a result, an optical pathlength between the light source and the photodetector can be reduced. In addition, the sensor can include a heat sink that can direct heat away from the light source. Moreover, the sensor can include shielding in the optical path between the light source and the photodetector. The shielding can reduce noise received by the photodetector.01-07-2010
20110257494SUB-MICRON SURFACE PLASMON RESONANCE SENSOR SYSTEMS - Wearable or implantable devices combining microfluidic control of sample and reagent flow and micro-cavity surface plasmon resonance sensors functionalized with surface treatments or coatings capable of specifically binding to target analytes, ligands, or molecules in a bodily fluid are provided. The devices can be used to determine the presence and concentration of target analytes in the bodily fluids and thereby help diagnose, monitor or detect changes in disease conditions.10-20-2011
20080214910SYSTEM AND METHOD FOR OPERATING AN ELECTROCHEMICAL ANALYTE SENSOR - A method of operating an electrochemical analyte sensor having one or more electrodes may comprise applying a time-varying input signal to at least one of the one or more electrodes, monitoring a time-varying output signal produced by the sensor in response to application of the time-varying input signal, determining a complex impedance of the sensor based on the time-varying input and output signals, and determining from the complex impedance information relating to operation of the sensor.09-04-2008
20110054277CONTACTLESS RESPIRATION MONITORING OF A PATIENT AND OPTICAL SENSOR FOR A PHOTOPLETHYSMOGRAPHY MEASUREMENT - The invention also relates to an optical sensor for a photoplethysmography measurement, comprising a light unit 03-03-2011
20110054276METHOD OF MONITORING AN AUTOMATED POINT-OF-CARE FLUID TESTING SYSTEM - A method of monitoring performance of a fluid testing system is provided. The method draws a fluid sample to the testing system using a pump. A voltage output of a sensor, such as an optical sensor, is generated. The voltage output of the optical sensor during the drawing is compared to an upper fluid volume drawn based voltage limit and a lower fluid volume drawn based voltage limit stored within a memory. The system is flushed with a flushing fluid using the pump to flush the flushing fluid from the testing system. The voltage output of the optical sensor during the flushing is compared to an upper fluid volume flushed based voltage limit and a lower fluid volume flushed based voltage limit stored within the memory. An alert generates if at least one of the voltage output during the drawing of the fluid sample is outside of voltage limits.03-03-2011
20110021890SET FOR DETERMINING BLOOD TYPE AND COVER BODY - Disclosed is a set for determining whether blood obtained in puncture tools by puncturing a blood vessel is venous blood or arterial blood easily, and ensuring handling under a sterile state. A set for determining blood type has a cover body to be attached to a syringe set, and a blood type determination unit to be housed in the cover body. The blood type determination unit comprises a light projecting portion and a light receiving element, and a blue output LED and a red output LED showing a judgment result based on a signal obtained from the light receiving element. The cover body has a body and a lid that are combined with each other to cover the blood type determination unit, a partition for passing blood between the light projecting portion and the light receiving element, and a pair of measurement windows for transmitting light between the light projecting portion and the light receiving element through the partition.01-27-2011
20110021889Continuous Analyte Measurement Systems and Systems and Methods for Implanting Them - Low profile continuous analyte measurement systems and systems and methods for implantation within the skin of a patient are provided.01-27-2011
20110071371Wavelength-Division Multiplexing In A Multi-Wavelength Photon Density Wave System - Multi-wavelength photon density wave medical systems, methods, and devices are provided. In one embodiment, a multi-wavelength photon density wave patient monitor includes multiple light sources, a driving circuit, a fiber coupler, a sensor cable connector, a wavelength demultiplexer, detectors, and data processing circuitry. The driving circuit may modulate the light sources to produce several single-wavelength input photon density wave signals, which the fiber coupler may join into a multi-wavelength input signal. The sensor cable connector may provide this multi-wavelength input signal to a sensor attached to the patient and receive a multi-wavelength output signal. The wavelength demultiplexer may separate the multi-wavelength output signal into single-wavelength output signals for detection by the detectors. Based on a comparison of one of the single-wavelength output signals to a corresponding one of the single-wavelength input signals, the data processing circuitry may determine a physiological parameter of the patient.03-24-2011
20100292546BREATHABLE PHYSIOLOGICAL SENSOR - A sensor includes a sensor pad that allows air and moisture to diffuse from a patient's skin. A light source is disposed on the sensor pad is configured to generate near-infrared light. A light detector disposed on the sensor pad is configured to detect near-infrared light generated by the light source.11-18-2010
20100222654OPTICAL-BASED PHYSIOLOGICAL SENSOR ASSEMBLY WITH DISPOSABLE BARRIER LAYER - A physiological sensor assembly includes a physiological sensor having at least one light source and at least one optical receiver. A substantially transparent barrier layer is disposed between the physiological sensor and the patient's skin such that the barrier layer is removably adhered to the physiological sensor and removably adhered to the patient's skin.09-02-2010
20090171171OXIMETRY SENSOR OVERMOLDING LOCATION FEATURES - The present disclosure relates to a frame for a sensor. In an embodiment, the frame includes a frame body and one or more surface features configured to position the frame body within a mold. In certain embodiments, some or all of the frame may be overmolded such that the overmold material is substantially flush with terminal surfaces of the respective one or more surface features.07-02-2009
20110137140Apparatus, Systems and Methods for Measuring Flow and Pressure within a Vessel - Exemplary embodiments of apparatus, system and method can be provided to measure a flow of fluid within an anatomical structure. For example, it is possible to use at least one first probe arrangement structured to be insertable into a vessel and configured to direct at least one radiation to at least one portion of the anatomical structure. Further, it is possible to provide at least one second arrangement which configured to detect an interference between a first radiation provided from the fluid via the probe arrangement and second a second radiation provided from a reference path as a function of wavelength thereof. Further, at least one third arrangement can be provided which is configured to determine at least one characteristic of the fluid as a function of the interference.06-09-2011
20110190606FLUID HANDLING CASSETTE - A fluid handling module that is removably engageable with a bodily fluid analyzer is provided. The module may comprise a fluid handling element, and a fluid component separator that is accessible via the fluid handling element and configured to separate at least one component of a bodily fluid transported to the fluid component separator. The fluid handling element may have at least one control element interface.08-04-2011
20110190605BIOLOGICAL INFORMATION DETECTOR, BIOLOGICAL INFORMATION MEASURING DEVICE, AND METHOD FOR DESIGNING REFLECTING PART IN BIOLOGICAL INFORMATION DETECTOR - To reduce the effect of directly reflected light on a contact-surface side of a contact member, a biological information detector includes a light-emitting part, a light-receiving part, a reflecting part, a protecting part for protecting the light-emitting part, and a substrate. The protecting member is formed from a material that is transparent with respect to a wavelength of the light emitted by the light-emitting part and has a contact member provided with a contact surface in contact with the detection site. Light emitted from the light-emitting part is inhibited from reflecting once on a contact-surface side of the contact member of the protecting part and being incident on a light-receiving region of the light-receiving part.08-04-2011
20110263953DEPLOYMENT SYSTEM AND METHOD FOR OPTICAL ANALYTE SENSOR - Embodiments of the invention are directed to a delivery device and method for deploying an optical analyte sensor. The delivery device comprises hollow tubes configured to operate telescopically. The optical sensor is configured to retract and extend from a distal end of the delivery device, by sliding the telescoping tubes with respect to one another. The delivery device may also have a locking mechanism such that the distal end portion of the sensor will extend to a preset locked position beyond the delivery device, e.g., during calibration and deployment. The device is capable of being used to ship, calibrate, and deploy the sensor while maintaining sterility and avoiding exposure to the external environment.10-27-2011
20100113898APPARATUS AND METHOD OF PROCESSING PLURALITY OF BIOLOGIC SIGNALS - An apparatus for integrally processing a plurality of biologic signals includes a first signal processing module and a second signal processing module. The first processing module generates a signal for operating a sensing module, which includes a plurality of sensor groups which measures the plurality of biologic signals, and which processes a biologic signal provided from the plurality of sensor groups based on a control signal. The second signal processing module authenticates a sensor group from among the plurality of sensor groups, generates the control signal according to a result of the authentication while automatically setting a processing condition, processes the biologic signal provided from the first signal processing module according to the processing condition and outputs a result of processing the biologic signal.05-06-2010
20100022856IMPLANTABLE OPTICAL HEMODYNAMIC SENSOR INCLUDING LIGHT TRANSMISSION MEMBER - An implantable medical device (IMD) includes an optical hemodynamic sensor comprising at least one optical emitter and at least one detector. In some examples, the at least one optical emitter may be optically coupled to at least one light transmission member that extends from a housing of the IMD. In addition, in some examples, the at least one detector may be optically coupled to at least one light transmission member that extends from the housing of the IMD. In other examples, an optical emitter and/or detector of a hemodynamic sensor may be carried by an extension member that extends from a housing of the IMD. The elongated member may electrically couple the optical emitter and/or detector to a controller or other components within the IMD housing.01-28-2010
20100022858SUBJECT OBSERVATION APPARATUS AND SUBJECT OBSERVATION METHOD - A subject observation apparatus of the invention includes: a light-emitting section for emitting a light to a subject; an optical modulation section for detecting a scattering angle of a return light from the subject and performing optical modulation on the return light in accordance with the scattering angle; and a signal output section for generating a signal to show a state of light scattering in the subject based on the light subjected to the optical modulation by the optical modulation section, and outputting the generated signal.01-28-2010
20100022859MULTIPLE WAVELENGTH SENSOR EMITTERS - A physiological sensor is adapted to removably attach an emitter assembly and a detector assembly to a fingertip. The emitter assembly is adapted to transmit optical radiation having multiple wavelengths into fingertip tissue. The detector assembly is adapted to receive the optical radiation after attenuation by the fingertip tissue. The sensor has a first shell and a second shell hinged to the first shell. A spring is disposed between the shells and urges the shells together.01-28-2010
20110218411FLUID HANDLING CASSETTE SYSTEM FOR BODY FLUID ANALYZER - A fluid handling system for use in bodily fluid analysis. The system comprises a first fluid handling module configured to interface with a main instrument. The first fluid handling module has a first fluid handling network and the first fluid handling network includes an infusate passage and an infusion fluid pressure member suitable for moving fluid within the infusate passage. The fluid handling system also has a second fluid handling module separate from the first module which is configured to interface with the main instrument. The second fluid handling module has a second fluid handling network and at least one sample analysis cell which is accessible via the second fluid handling network. The first and second modules are configured to interconnect and provide fluid communication between the first and second fluid handling network and the sample cells.09-08-2011
20100016688Optical methods for real time monitoring of tissue treatment - The present invention comprises methods and systems/devices for non-invasively measuring baseline collagen and collagen changes during treatment of tissue, e.g., denaturation by the application of RF energy, through linear dichroism, circular dichroism, or birefringence. The invention optionally uses polarization sensitive optical measurements to discriminate between denaturation of unidirectionally oriented strands of collagen, such as a ligament or tendon, and denaturation of planar collagen surfaces, such as the dermal layer of the skin or collagen in joint capsules.01-21-2010
20110306856SYSTEMS AND METHODS FOR MEASURING MULTIPLE ANALYTES IN A SAMPLE - Systems and methods for analyzing multiple components of a fluid sample are provided. In certain embodiments, a system can include an analyte detection system configured to measure first analyte data in a first component of a fluid sample received from a patient and measure second analyte data in a second component of a fluid sample. In some embodiments, one or more portions of an optical system is movable with respect to other portions of the system in order to optically and/or electrochemically analyze multiple components of a fluid sample. In other embodiments, optical and/or electrochemical analysis can be performed simultaneously on multiple components of a fluid sample. In some embodiments, a first analyte can be measured in a sample (e.g., whole blood) before the sample is separated into its components (e.g., plasma, red blood cells, etc.), and a second analyte can be measured in a component of the sample after separation.12-15-2011
20110306854SYRINGE-BASED WHISPERING GALLERY MODE MICRORESONATOR MICROFLUIDIC BIOCHEM SENSOR - A syringe-based whispering gallery mode sensor includes a syringe including an assembly provided its needle, the assembly including (12-15-2011
20120041289SYSTEM AND METHOD FOR STIMULATION OF BIOLOGIC SIGNALS IN A BIO-ELECTRO-PHYSIOLOGIC MATRIX - An implantable device for monitoring physiological changes in an organism is disclosed. The device includes a matrix positioned proximate a biological material of the organism, an irradiation device associated with the matrix for exposing the biological material to radiation, and a sensor device associated with the matrix for detecting a response of the biological material to the irradiation. The response can be used to remotely detect a characteristic of the biological material.02-16-2012
20120041288NON-INVASIVE BIOMEDICAL DETECTION AND MONITORING SYSTEMS - The present disclosure relates to a non-invasive and continuous biomedical detections and non-invasive and continuous monitoring methods and devices for extracting and analyzing interstitial fluid extracted non-invasively and continuously from the skin of a subject comprising non-invasively electroporating the skin using a non pulsed voltage in combination with a pulsed voltage and applying negative pressure02-16-2012
20120232363NONINVASIVE MULTI-PARAMETER PATIENT MONITOR - Embodiments of the present disclosure include a handheld multi-parameter patient monitor capable of determining multiple physiological parameters from the output of a light sensitive detector capable of detecting light attenuated by body tissue. For example, in an embodiment, the monitor is capable of advantageously and accurately displaying one or more of pulse rate, plethysmograph data, perfusion quality, signal confidence, and values of blood constituents in body tissue, including for example, arterial carbon monoxide saturation (“HbCO”), methemoglobin saturation (“HbMet”), total hemoglobin (“Hbt”), arterial oxygen saturation (“SpO09-13-2012
20120209093IMAGING BASED VIRUS DETECTION - A method for detecting a virus in a patient based on imaging data includes scanning a region of interest of the patient with an imaging device and generating imaging data indicative of the region of interest, identifying at least one marker in the image data that corresponds to the virus based on the identified at least one marker and a set of predetermined imageable markers that correspond to the virus, classifying the virus as a particular strain of the virus based on a set of classification rules, and generating a signal indicative of the particular strain. The method optionally includes generating a signal indicative of the classification and electronically conveying the signal to at least one entity.08-16-2012
20120046530MULTIPLE WAVELENGTH SENSOR DRIVERS - A physiological sensor includes an electrical grid to activate one or more light emitters by addressing at least one row conductor and at least one column conductor. Each light emitter includes a positive terminal and a negative terminal. The physiological sensor includes a first light emitter and a second light emitter. A first contact is communicatively coupled with the positive terminal of the first light emitter, the negative terminal of the second light emitter, a first row conductor, and a first column conductor. A second contact is communicatively coupled with the negative terminal of the first light emitter, the positive terminal of the second light emitter, a second row conductor, and a second column conductor. The first light emitter is activated by addressing the first row conductor and the second column conductor. The second light emitter is activated by addressing the second row conductor and the first column conductor.02-23-2012
20120209092NON-INVASIVE APPARATUS AND METHOD FOR MEASURING HUMAN METABOLIC CONDITIONS - In a non-invasive human metabolic condition measuring apparatus and method, a micro-light source emits an incident light having a wavelength from 329 nm to 473 nm to trigger a mitochondrial metabolite of a human mucosa tissue, and the metabolite is excited to generate a fluorescent signal having a wavelength from 405 nm to 572 nm, and the fluorescent signal is filtered by an optical filter, received by a micro receiver, and amplified by an amplification circuit sequentially, and then a filter circuit and an analog/digital conversion circuit of a microprocessing unit are provided for filtering and performing an analog/digital signal conversion respectively, so that the metabolite content can be calculated by the computation to provide human metabolic conditions, and a combination of micro components and circuits is used for miniaturizing the apparatus to provide a convenient carry of the apparatus.08-16-2012
20120010483INTRA-OPERATIVE USE OF FLUORESCENCE SPECTROSCOPY AND APPLICATIONS OF SAME - In one aspect, the present invention relates to a process for intra-operatively providing anatomical guidance in endocrine surgery. In one embodiment, the process includes the steps of illuminating tissues in the neck area of a living subject with a beam of light having a predetermined wavelength, obtaining Raman data from light scattered from the illuminated tissues, finding Raman signatures corresponding to thyroid or parathyroid tissues from the obtained Raman data, and identifying the thyroid or parathyroid tissues from the corresponding Raman signatures.01-12-2012
20120010484PHOTOBIOLOGICAL MEASURING DEVICE AND ANALYZING METHOD - A photobiological measuring device has a computing unit generating an unwanted component removal observation signal by removing the signal corresponding to the unwanted component from an observation signal. The computing unit is provided with: a mixing matrix making unit for separating observation signals into the products of a mixing matrix and independent component signals through independent component analysis; a power spectrum computing unit generating transformed independent component signals, which are functions of frequency and intensity, by Fourier transforming the independent component signals, which are functions of time and intensity, and computing power spectra in predetermined frequency bands of transformed independent component signals; and an unwanted component signal determining unit detecting the independent component signal corresponding to the unwanted component from among the independent component signals by comparing the power spectrum in a predetermined frequency band of each transformed independent component signal with a threshold.01-12-2012
20120065483RTLS TAG, RTLS READER AND LIVESTOCK MANAGEMENT SYSTEM USING THE SAME - A livestock management system according to the embodiment includes an RTLS tag attached to a livestock to transmit analysis information of a blood gathered from the livestock and ID information dedicated for the RTLS tag, a reader transmitting the analysis information and ID information transmitted thereto from the RTLS tag to a server and transmitting a distance value with respect to the RTLS tag to the server upon a request of the server, and the server calculating a position of the livestock having the RTLS tag based on the distance value transmitted thereto from the reader and transmitting position information of the livestock and the analysis information of the blood to a client according to the position of the livestock.03-15-2012
20120310055ULTRA-WIDE BAND NON-INVASIVE BIOLOGICAL SENSOR AND METHOD - The disclosure provides an electromagnetic (EM) sensor system and method that permits rapid and non-invasive measurement of blood glucose or other biological characteristics that exhibits a unique spectral signature, such as its complex electrical permittivity within the frequency range from near DC to microwave frequencies. Low-level EM signals are coupled through the skin and modified by electrical properties of the sub dermal tissues. These tissues essentially integrate with the sensor circuit as they interact with the transmitted EM energy. The guided-wave signal can be sampled and converted to a digital representation. The digital information can be processed and analyzed to determine the frequency-sensitive permittivity of the tissues and a determination of blood glucose level is made based upon the sensor output. The sensor design and method has wide-ranging applicability to a number of important measurement problems in industry, biology, medicine, and chemistry, among others.12-06-2012
20120071738METHODOLOGY AND EQUIPMENT OF OPTICAL ROTATION MEASUREMENTS - A small-size optical rotation measuring device for detecting an organism, a tissue, blood, or molecules having rotatory power and determining the content thereof with high accuracy and an optical rotation measuring method for detecting an organism, a tissue, blood, or molecules having rotatory power and determining the content thereof with high accuracy. A nonreciprocal optical system is disposed in a loop optical path of a ring optical interferometer, and thereby light beams of circularly polarized modes orthogonal to each other are propagated in opposite directions through a sample to be measured. The wavelength of the light beams from a light source is in a wavelength region where the loss by the nonreciprocal optical element is low. A signal processing technique for phase-modulation optical fiber gyro having the highest resolution among ring interferometers is applied.03-22-2012
20110077480FLUID TRANSFER SYSTEM AND METHOD - Devices and methods for automatic monitoring of fluid of a patient are disclosed, comprising a patient line, a transfer disk which receives the fluid and controllably transfers the fluid to test substrates, and a sensor disk which houses the test substrates. The sterile transfer disk may be configured to maintain the sterility of the patient sampling assembly while transferring samples to non-sterile components, such as the sensor disk.03-31-2011
20120253148FLEXIBLE BANDAGE EAR SENSOR - The present disclosure relates to sensors for use on a patient's ear. The sensors as provided may be disposable and configured to be retained on an ear with a biasing mechanism. In particular embodiments, the biasing mechanism is a sliding clip that is configured to bias a first portion and a second portion of a sensor body towards one another.10-04-2012
20110105865DIFFUSE REFLECTANCE SPECTROSCOPY DEVICE FOR QUANTIFYING TISSUE ABSORPTION AND SCATTERING - A diffuse reflectance spectroscopy system for quantifying electromagnetic absorption and scattering in a tissue is provided. Also provided are optical probes and methods for imaging a tissue mass. In some embodiments, the methods include the steps of contacting a tissue mass with an optical probe, wherein the optical probe includes at least one entity for emitting light that interacts with a tissue mass and then is remitted to a collecting entity, for collecting the light that has interacted with the tissue mass, wherein the collecting entity comprises a detector comprising one or more photodiodes; measuring turbid spectral data of the tissue mass using the optical probe; converting the turbid spectral data to at least one of absorption and scattering spectral data via a Monte Carlo algorithm or a diffusion algorithm; and quantifying tissue compositions and scatterer size in a tissue mass using the at least one of absorption and scattering spectral data.05-05-2011
20100094106SECONDARY-EMITTER SENSOR POSITION INDICATOR - A secondary-emitter sensor position indicator has primary emitters that transmit light having primary wavelengths and at least one secondary emitter that transmits light having at least one secondary wavelength. A detector outputs a sensor signal in response to received light. An attachment assembly, in a sensor-on condition, positions the emitters and detector relative to a tissue site so that the sensor signal is substantially responsive to the primary wavelength light after attenuation by pulsatile blood flow within the tissue site and is negligibly responsive to the secondary wavelength light. The attachment assembly, in a sensor out-of-position condition, positions the secondary emitter relative to the tissue site so that the sensor signal is at least partially responsive to the secondary wavelength.04-15-2010
20090131770CONFORMABLE PHYSIOLOGICAL SENSOR - A sensor for measuring physiological characteristics includes a circuit assembly, at least one material layer, and an adhesive layer that extends beyond an outer edge of the circuit assembly. The at least one material layer forms an adhesive edge around the perimeter of the sensor.05-21-2009
20120130208COEFFICENT DETERMINATION FOR BLOOD OXYGEN SATURATION AND TOTAL HEMOGLOBIN CONCENTRATION INDICES - A first concentration of a chromophore corresponding to a measurement volume of an optical sensor is determined. A second concentration of the chromophore is obtained in the vicinity of the measurement volume corresponding to a change in at least one of a total concentration of the chromophore and a relative concentration of a first form of the chromophore to the total concentration of the chromophore in the measurement volume. Light remittance measurements including a first light wavelength and a second light wavelength are obtained corresponding to the first chromophore concentration and the second chromophore concentration. A coefficient for computing an index of a change in the chromophore concentration is computed using the difference between the first and second chromophore concentrations and the first and second light remittance measurements.05-24-2012
20120220839PROSTHETIC COMPONENT FOR MONITORING SYNOVIAL FLUID AND METHOD - A prosthetic component suitable for long-term implantation is provided. The prosthetic component includes electronic circuitry and sensors to measure a parameter of the muscular-skeletal system. The prosthetic component comprises a first structure having at least one support surface, a second structure having at least one feature configured to couple to bone, and at least one sensor. The electronic circuitry and sensors are hermetically sealed within the prosthetic component. One or more sensors can be used to monitor synovial fluid in proximity to the joint to determine joint health. The prosthetic component includes a transmissive region. One or more optical sensors are mounted in proximity to the transmissive region. Periodic measurements of the synovial fluid are measured through the transmissive region. The measurements can include color and turbidity of the synovial fluid. The color and turbidity data can be compared against known data to determine joint status.08-30-2012
20120226116TEST MEDIA CASSETTE FOR BODILY FLUID TESTING DEVICE - A bodily fluid sampling device includes a piercing device and a sensor enclosed in a housing. A cassette, which contains test media, is positioned proximal to the sensor so that the sensor is able to analyze a bodily fluid sample collected on the test media. The cassette includes a supply portion from which unused test media is supplied and a storage portion in which contaminated test media is stored after exposure to the bodily fluid. The cassette is adapted to collect a series of bodily fluid samples without requiring disposal of the test media.09-06-2012
20100049016Noninvasive Transdermal Systems for Detecting an Analyte in a Biological Fluid and Methods - The present invention relates to noninvasive transdermal systems comprised of a noninvasive transdermal patch and a reflectometer. The noninvasive transdermal patches are comprised of a wet chemistry component and a dry chemistry component. The wet chemistry component is a liquid transfer medium in the form of a gel layer for the extraction and liquid bridge transfer of the analyte of interest from the biological fluid within or beneath the skin to the dry chemistry component. The dry chemistry component is a reagent system for interacting with the analyte of interest (glucose) to generate a color change. The reflectometers include a modulated light source for emitting light to illuminate a target surface which possesses a certain color and shade of color for detection by an optical detector. The output signal is processed for determining a corresponding quantity of quality measurement.02-25-2010
20100049015SPECIFICITY OF ANALYTE DETECTION IN ETALONS - A system and method is provided for detecting concentration of an analyte in a fluid. A first container includes (i) an optical cavity detection region, (ii) a reservoir for one or more modifiers of one or more optical properties of the optical cavity detection region, and (iii) a set of one or more bounding regions through which objects in the fluid can transfer into the container. The optical cavity detection region and the reservoir define separate areas of the first container. The movement of the one or more modifiers between the reservoir and the optical cavity detection region is responsive to changes in concentration of the analyte. A second container includes an optical cavity detection region, and a set of one or more bounding regions through which objects in the fluid can transfer into the container. Also provided are optical components for guiding light into the optical cavity detection regions of the first and second containers.02-25-2010
20090105565OPTICAL DEVICE COMPONENTS - Embodiments of the invention relate to an apparatus including a light source to generate a plurality of light beams with each of the plurality of light beams having a different wavelength range. The apparatus also includes a light funnel to direct the plurality of light beams to the target area, an aperture to direct the plurality of light beams emitting from the target area to a lens, the lens configured to collect the light beams emitting from the target area. Further, the apparatus includes a detector including a plurality of light-sensing devices each configured to detect a light beam and configured to generate an output signal indicative of an intensity of light detected and a processor for determining the blood characteristic as a function of each generated output signal.04-23-2009
20100298672METHODS FOR EVALUATING A SUBJECT USING DATA ASSOCIATED WITH A FLUORESCENT ANALYTE - Methods, systems, devices and computer program product include: (i) administering a fluorescent analyte to a subject; (ii) repetitively emitting excitation light from a sensor over a desired monitoring period; (iii) detecting fluorescence intensity in response to the excitation light using the sensor that outputs the excitation light; and (iv) using data associated with the detected fluorescence intensity to perform at least one of: (a) calculate the concentration or dose of the analyte received proximate to the sensor site; (b) evaluate the pharmacodynamic or pharmacokinetic activity of the fluorescent analyte; (c) confirm Ab attachment to a tumor site; (d) monitor a non-target site to confirm it is not unduly affected by a therapy; (e) monitor for changes in cellular properties; (f) use the calculated dose or concentration data to adjust or customize a therapeutic amount of the analyte administered to the subject; (g) confirm micelle concentration at a target site and then stimulate toxin release based on the confirmation; and (h) monitor for the expression of a protein produced from a gene therapy modification.11-25-2010
20120238838System, devices, and methods for real-time monitoring of cerebrospinal fluid for markers of progressive conditions - Systems, devices, methods, and compositions are described for providing real-time monitoring of cerebrospinal fluid for markers of progressive conditions.09-20-2012
20100010325System for Noninvasive Determination of Analytes in Tissue - An apparatus and method for noninvasive determination of analyte properties of human tissue by quantitative infrared spectroscopy to clinically relevant levels of precision and accuracy. The system includes subsystems optimized to contend with the complexities of the tissue spectrum, high signal-to-noise ratio and photometric accuracy requirements, tissue sampling errors, calibration maintenance problems, and calibration transfer problems. The subsystems can include an illumination/modulation subsystem, a tissue sampling subsystem, a data acquisition subsystem, a computing subsystem, and a calibration subsystem. The invention can provide analyte property determination and identity determination or verification from the same spectroscopic information, making unauthorized use or misleading results less likely than in systems that use separate analyte and identity determinations. The invention can be used to control and monitor individuals accessing controlled environments.01-14-2010
20120253146Optical Instrument With Audio Band Frequency Response - A system and method for determining physiological parameters of a patient based on light transmitted through the patient. A light drive signal may be generated by an audio codec in a processor and utilized to generate the light transmitted through the patient. Additionally, the processor may calculate physiological parameters of the patient based on digital data signals converted in the audio codec that are indicative of absorption of light in the patient.10-04-2012
20120190944DEVICES AND METHODS FOR NON-INVASIVE OPTICAL PHYSIOLOGICAL MEASUREMENTS - An optical measurement device and method of use provides non-invasive physiological measurements from a predetermined location on a body part of a user. The optical measurement device provides an illumination and detection assembly configured to generate and detect light of a predetermined wavelength range in the form of a photoplethysmography (PPG) signal, as well as a pressure detection assembly configured to detect an amount of pressure applied to the measurement device by the user being measured. A feedback unit, such as a portable display device, provides the user real-time feedback of the detected PPG signal and level of applied pressure so that the user may adjust the amount of applied pressure to improve the quality of the detected PPG signal.07-26-2012
20110124987Methods for Measuring Changes in Optical Properties of Wound Tissue and Correlating Near Infrared Absorption (FNIR) and Diffuse Reflectance Spectroscopy Scattering (DRS) With Tissue Neovascularization and Collagen Concentration to Determine Whether Wound is Healing - Optical changes of tissue during wound healing measured by Near Infrared and Diffuse Reflectance Spectroscopy are shown to correlate with histologic changes. Near Infrared absorption coefficient correlated with blood vessel in-growth over time, while Diffuse Reflectance Spectroscopy (DRS) data correlated with collagen concentration. Changes of optical properties of wound tissue at greater depths are also quantified by Diffuse Photon Density Wave (DPDW) methodology at near infrared wavelengths. The diffusion equation for semi-infinite media is used to calculate the absorption and scattering coefficients based on measurements of phase and amplitude with a frequency domain or time domain device. An increase in the absorption and scattering coefficients and a decrease in blood saturation of the wounds compared to the non wounded sites was observed. The changes correlated with the healing stage of the wound. The methodologies used to collect information regarding the healing state of a wound may be used to clinically assess the efficacy of wound healing agents in a patient (e.g., a diabetic) and as a non-invasive method05-26-2011
20110004079OPTICAL SENSOR INCLUDING DISPOSABLE AND REUSABLE ELEMENTS - An embodiment of the present disclosure provides a noninvasive optical sensor or probe including disposable and reusable components. The assembly of the disposable and reusable components is straightforward, along with the disassembly thereof. During application to a measurement site, the assembled sensor is advantageously secured together while the componentry is advantageously properly positioned.01-06-2011
20120323092Robust Powering of Implantable Biosensor Platform - An implantable device for measuring biological information of a body is provided, wherein the implantable device includes a receiver for receiving electromagnetic energy and converting the electromagnetic energy into electrical energy; a storage capacitor associated with the receiver such that the electrical energy from the receiver is stored in the storage capacitor; a biological sensor; a processing device; and a transmitter, wherein the biological sensor, processing device and transmitter are configured to receive electrical energy from the storage capacitor, and wherein the biological sensor, processing device and transmitter are configured such that when the receiver is receiving electromagnetic energy, the biological sensor, processing device and transmitter are inactive and when the receiver is not receiving electromagnetic energy, the biological sensor, processing device and transmitter are inactive.12-20-2012
20100249546APPARATUS FOR NON-INVASIVE SPECTROSCOPIC MEASUREMENT OF ANALYTES, AND METHOD OF USING THE SAME - An apparatus for spectroscopic evaluation of a subject's body fluids may be used at the interstitial region adjacent to or in between a subject's extremities using a spectroscopic probe. The spectroscopic probe may possess one or more of the movements such as rotational, translational, and/or vertical freedom necessary for the probe to contact the subject's tissue at a consistent angle and pressure while accommodating the different size of the subject's extremities, and may be housed in a device optimized for attaining reproducible blood flow to the region of the subject that is measured, and for minimizing the effects of the housing pulling, stretching, pressing, compressing the subject's skin. A pressure sensor may be used to ensure that measurements are taken at an optimal pressure. A touch sensor may be used to activate a system and/or to ensure flushness. In addition, the spectroscopic measurement may be coupled with a temperature measurement means that detects the subject's local body temperature in or near the region being measured, or the subject's core or mean body temperature, or the ambient temperature proximate to the probe, or any combination of those measurements. The system may also include one or more indicators to communicate information to a test subject.09-30-2010
20120277553SPECTROPHOTOMETRIC MEASUREMENT IN COLOR-BASED BIOCHEMICAL AND IMMUNOLOGICAL ASSAYS - A process is provided for analyzing a specimen of biological material in any of a number of biochemical or immunological tests for an analyte which involves subjecting the specimen to treatment which develops a color correlating to the amount of analyte in the specimen. According to the invention at least one defined color characteristic selected from hue angle, chroma, saturation and lightness of the developed color is measured and the results of that measurement analyzed to determine the presence or concentration of the analyte in the specimen. Particular applications are to the detection of cancerous or pre-cancerous abnormalities from the analysis of lung mucus, throat mucus, cervical mucus or seminal fluid.11-01-2012
20110245636Multi-Wavelength Photon Density Wave System Using An Optical Switch - Multi-wavelength photon density wave (PDW) medical systems, methods, and devices are provided. In one embodiment, a multi-wavelength system may include a sensor, a sensor cable, and a patient monitor. The sensor may have an emitter and a detector configured to pass a multi-wavelength PDW input signal into a patient and receive a resulting multi-wavelength PDW output signal. The sensor cable may couple to the sensor and include two optical cables for transmitting and receiving the multi-wavelength PDW signals. The patient monitor may couple to the sensor cable and generate several single-wavelength PDW input signals by modulating a plurality of light sources. The monitor may include an optical switch configured to time-division multiplex the several single-wavelength PDW wave input signals by selecting one of the single-wavelength PDW signals at one time to produce a multi-wavelength PDW signal which is output from the monitor to the sensor via the sensor cable.10-06-2011
20120088991ALGORITHM FOR PHOTONIC NEEDLE CONSOLE - Needles are widely used in interventional radiology. Each medical application requires a specific needle type. The same holds for the photonic needles which analysis depends on the type of application the clinician aims for. Therefore, it is relevant to have the X-ray machine recognize the type of needle that is being used and to load the required software for the tissue analysis. It is therefore proposed to have a data link established between the imaging modality used for the acquisition of the patient anatomy (X-ray, CT, MR or US) and the system that processes optical data from the needle, so that the information from this imaging modality can be used to guide the processing. In a preferred embodiment the selection is made by reading out the code present in the disposable needle when it is connected to the console.04-12-2012
20110306855DEVICE, SYSTEM AND METHOD FOR DETECTION OF BLEEDING - A device, system and method for detecting bile and blood are provided. The device may comprise a housing having a gap through which in-vivo fluids may flow, illumination sources on one side of the gap, a light detector which is facing the illumination sources and is positioned on the opposite side of the gap for detecting light which passes through the in-vivo fluids, and a transmitter to transmit the detected signals generated according to the detected light. The system may further comprise a receiver to receive the detected signals transmitted by the transmitter, and a processor. The method may comprise comparing the detected signals with a predetermined threshold calculated from the transmission spectra of bile and of blood and determining the presence and/or concentration of bile and blood in-vivo.12-15-2011
20110319730BIO-PHOTONIC FEEDBACK CONTROL SOFTWARE AND DATABASE - A process, apparatus, and method for online control and database collection and management of a computerized detection, tracking, and feedback control system. The system tests for nutrients by Raman scattering effects on skin or other tissues to determine the content of carotenoids or other nutrients as evidenced in that skin. Serum levels of nutrients may vary dramatically with time, but skin tissues may average such nutrition over time. Skin and other tissues may be scanned with light to produce accurate measurements of carotenoids or other nutrients accumulated in the skin based on the Raman scattering affect of those nutrients in the skin. A score can be derived from a properly calibrated bio-photonic scanner to reflect an averaged effective uptake of the detected nutrient (e.g. such as the carotenoid example).12-29-2011
20130018237APPARATUS FOR NON-INVASIVE IN VIVO MEASUREMENT BY RAMAN SPECTROSCOPY - A metabolite concentration is measured in vivo using Raman spectroscopy in such a way as to receive at a detector (01-17-2013
20110160552SINE SATURATION TRANSFORM - A transform for determining a physiological measurement is disclosed. The transform determines a basis function index from a physiological signal obtained through a physiological sensor. A basis function waveform is generated based on basis function index. The basis function waveform is then used to determine an optimized basis function waveform. The optimized basis function waveform is used to calculate a physiological measurement.06-30-2011
20080234560Optical measurement instrument for living body semiconductor laser installation for living body light measuring device - A living body measuring instrument having a sub-mount on which plural light-emitting devices oscillating at different wavelengths are mounted in proximity, one optical output monitoring device that detects the optical outputs of these light-emitting devices and a light source mounted on the same heat sink which are housed in one can-package, a light-receiving device that detects a signal from a living body, and a circuit that separates the optical output signals from the light-emitting devices, wherein at least one light-emitting device has a light-emitting layer including a In09-25-2008
20080228049Systems, Circuits and Apparatus For In Vivo Detection of Biomolecule Concentrations Using Fluorescent Tags - Systems are disclosed wherein labeled binding molecules can be provided in vivo to tissue having biomolecules that specifically bind the labeled binding molecule. A first optical radiation is emitted into the tissue in vivo to excite the labeled binding molecule bound to the biomolecule in vivo. A second optical radiation that is emitted by the excited labeled binding molecule, in response to the excitation thereof, can be detected in vivo. Related telemetric-circuits and apparatus are also disclosed.09-18-2008
20080221414Method for detection of aberrant tissue spectra - A method is provided for determining contact of a sensor with a patient's tissue. The method comprises comparing the intensity of detected light at a first wavelength to a threshold, wherein the first wavelength is not used to determine a physiological characteristic of the patient, and determining if the sensor is in contact with the patient's tissue based on the comparison. In addition, a method is provided for determining the amount of light shunting during operation of the sensor. The method comprises comparing the intensity of detected light at a first wavelength to a threshold, wherein the first wavelength is not used to determine a physiological characteristic of the patient, and determining the amount of light shunting based on the comparison.09-11-2008
20080221413Multiple configuration medical sensor and technique for using the same - A sensor may be adapted to be placed on multiple tissue sites. A sensor is provided that may have one configuration associated with use on a digit and a second configuration associated with use on another tissue site, such as a forehead. Further, a sensor may be adapted to be a transmission-type sensor or a reflectance-type sensor, depending on its configuration.09-11-2008
20080221412Method and apparatus for spectroscopic tissue analyte measurement - Methods and systems for calculating body fluid metrics are provided. In accordance with an exemplary embodiment of the present technique, there is provided a method for calculating body fluid metrics by acquiring an absorbance spectrum of a subject's tissue over a range of near-infrared light, performing a multi-linear regression of the absorbance spectrum of the subject's tissue in relation to absorbance spectra of tissue constituents, and calculating body fluid metrics based on the results of the multi-linear regression. A system is provided having a sensor for emitting the light into the subject's tissue and detecting reflected, scattered, or transmitted light, a spectrometer for processing the detected light and generating the absorbance spectrum of the subject's tissue, memory for storing absorbance spectra of the tissue constituents and a multi-linear regression model, and a processor for performing the multi-linear regression and calculating the body fluid metrics.09-11-2008
20080221411System and method for tissue hydration estimation - A system and method are provided for determining tissue hydration. The method includes transmitting electromagnetic radiation at tissue and detecting the absorption spectrum of the tissue using a spectrum analyzer located in a sensor. Further, the method includes providing a signal correlative to the absorption spectrum from the spectrum analyzer to a monitor and processing the signal to determine an amount of water content in the tissue.09-11-2008
20080221410Method for identification of sensor site by local skin spectrum data - A method is provided for determining the location of the sensor. The method comprises determining a physiological parameter based on detected light and determining the location of the sensor based on the physiological parameter. In addition, a method is provided for operating a sensor that includes calibrating a sensor based on a patient-specific physiological parameter, in which the patient-specific physiological parameter is skin color, age, gender, pooled blood, venous blood pulsation, or abnormal tissue.09-11-2008
20080221408System and methods for optical sensing and drug delivery using microneedles - The current techniques provide a system for monitoring a physiological parameter of a patient using microneedles that are coupled to an optical system, allowing spectroscopic measurements to be made immediately below the outer layer of the epidermis. In embodiments of the present invention, the results of the spectroscopic measurements are used to control the administration of a drug through an intravenous tube. In other embodiments, the microneedles may be coated with a drug for administration to the patient. In other embodiments, the microneedles may be mounted in a probe, wherein an actuator is used to move the needles into contact with the skin, and a drug delivery system is used to infuse the drug into the patient. A method for making needles is also provided.09-11-2008
20120253147CALIBRATION METHOD AND ARRANGEMENT AND SENSOR FOR NON-INVASIVELY MEASURING BLOOD CHARACTERISTICS OF A SUBJECT - A calibration method for an apparatus for non-invasively monitoring blood characteristics of a subject is disclosed. The apparatus is provided with a computational model representing a relationship between in-vivo measurement signals obtained from the subject and the blood characteristics. The providing includes employing at least one tissue property variable in the computational model, in which the at least one tissue property variable is indicative of absorption and scattering characteristics of the subject's tissue. An arrangement for determining blood characteristics of a subject and a sensor for the arrangement are also disclosed.10-04-2012
20130131469ANALYTE SENSOR - Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory system.05-23-2013
20130131470METHODS AND SYSTEMS FOR IN VIVO CLINICAL DATA MEASUREMENT OF ANALYTES - The present invention provides apparatuses, systems, and methods for real-time measuring of analytes in a biological fluid sample of a subject. In particular, the present invention provides a combination of micro-dialysis catheter, a micro-volume pump, and a spectrometer device that are operatively connected to one another to provide real-time measurement of analytes in a biological fluid sample of a subject.05-23-2013
20130144136METHOD AND APPARATUS FOR DETERMINING TISSUE HYDRATION - The present invention provides a system for the measurement of a tissue hydration value in a subject comprising a microprocessor and a sensor system having a light source and a light detector. Light is projected from the light source towards the tissue of a subject. The light projected either passes through or off of the tissues of the subject and is then received by the light detector. The light detector transmits a measurement of light intensity received by the detector to the microprocessor. The microprocessor is programmed with a tissue hydration model that utilizes the measurement of light intensity to determine the tissue hydration value for the subject.06-06-2013
20110218412LIVING-BODY COMPONENT MEASURING APPARATUS - A living-body component measuring apparatus measures a component of an inner tissue of a living body serving as an object to be measured by emitting laser light having two or more wavelengths from a light source and measuring reflected light of the laser light from the inner tissue of the living body. The living-body component measuring apparatus includes a beam splitter that changes optical paths of a part of the laser light and the reflected light, a reference-light measuring unit that measures, as reference light, the part of the laser light having the optical path changed by the beam splitter, a reflected-light measuring unit that measures the reflected light having the optical path changed by the beam splitter, and an analysis unit that analyzes the inner tissue by measuring a spectrum of the reflected light or the reference light.09-08-2011
20110224513pH MEASUREMENT, ABNORMAL-REGION DETECTION, LIVING-MATTER ANALYSIS METHODS AND APPARATUSES - A pH is measured by generating pulsed excitation-light including a wavelength that can excite a plurality of kinds of fluorescent-material in living matter that act as coenzyme in oxidation/reduction reaction in vivo, and the intensity of the light not damaging a tissue nor a cell and substantially not changing pH, and by illuminating a predetermined position in the living matter with the light, and by receiving fluorescence, and by resolving the intensity of the fluorescence into time domains the number of which is greater than that of the fluorescent-material, and by detecting the intensities of the fluorescence in the respective time domains, and by obtaining, based on the intensities, approximate-curves having gradients unique to the fluorescent-materials, respectively, and by calculating fluorescence lifetimes of at least two of the plurality of kinds of fluorescent-material based on the approximate-curves, and by measuring the pH of the living matter based on the lifetimes.09-15-2011
20100286494USING COLORED PROBES IN PATIENT MONITORING - The present disclosure provides a sensor with color-coded indications that various patient physiological parameters are being monitored, such as blood oxygen saturation, blood pressure, respiration rate, and respiration effort. The sensor may sense a physical characteristic used to monitor the physiological parameter, and a visible light emitter emits visible light of a first color that is color-coded to the physiological parameter, but is not used to sense the physical characteristic. The visible light emitter may emit visibly flashing light in response to the sensor sensing a threshold value of the physical characteristic. The sensor may include a second light emitter that may sense the physical characteristic, and may emit light of a second color that is color-coded to a first or second physiological parameter. In some embodiments, the first and second colors may visibly mix. The first and second visible light emitters may emit light independently, including visibly flashing light.11-11-2010
20110237908OPTICAL DEVICE AND BIOLOGICAL INFORMATION DETECTOR - An optical device including a contact part having a contact surface and an opposing surface, the contact surface coming into contact with a test subject and the opposing surface being opposite the contact surface; a support body installed on the opposing surface; a first element supported by the support body; and a second element disposed between the opposing surface and the support body; wherein one of the first element and the second element is a light-emitting element for emitting light towards a detection site of the test subject; another of the first element and the second element is a light-receiving element for receiving reflected light, the reflected light being light emitted by the light-emitting element and reflected at the detection site; and the contact part is formed from a material that is transparent with respect to a wavelength of the light emitted by the light-emitting element.09-29-2011
20130190579METHOD AND APPARATUS FOR LIGHTED TEST STRIP - A test strip with a sample chamber is secured to a meter. The sample chamber in the portion of the test strip that extends out of the meter is illuminated by transmitting light from a light source inside the meter internally through the test strip towards the sample chamber. By way of analogy, the test strip acts in a fashion similar to a fiber optic cable or optical wave guide by transmitting the light from the meter to the remotely located sample chamber that extends outside the meter. The user is then able to easily see the sample chamber of the test strip in dark conditions so that the user is able to readily align the sample chamber with the drop of fluid on the skin as well as view the sample chamber in order to ensure proper filling. The light also illuminates a test strip slot into which the test strip is inserted.07-25-2013
20120029326METHOD FOR MEASURING A CONCENTRATION OF A BIOGENIC SUBSTANCE CONTAINED IN A LIVING BODY - The object of the present invention is to provide a method for measuring concentration of a biological substance contained in a living body in which deterioration of the accuracy due to the reflected light and the interruption component is suppressed. Linear-polarized light is emitted to a particle chip implanted in the skin with modulating its modulating direction continuously. A surface enhanced Raman scattering light of the biological substance generated on the particle chip. A concentration of the biological substance is calculated based on the received signal. The receiving signal satisfy the following equation (III).02-02-2012
20120083678System and method for raman chemical analysis of lung cancer with digital staining - The present disclosure provides for a system and method for diagnosing biological samples that combines the visual staining features familiar to pathologists with the accurate, reliable, and nondestructive capabilities of Raman chemical imaging. The invention disclosed herein may be applied to diagnose lung cancer samples. A method may comprise illuminating a biological sample to generate interacted photons, filtering said interacted photons using a tunable filter, and detecting interacted photons to generate a test Raman data set representative of said sample. The method may further comprise applying at least one chemometric technique and/or a digital stain to said test Raman data set. This test Raman data set may be analyzed to diagnose said sample as comprising at least one of: adenocarcinoma, mesothelioma, and combinations thereof. A system may comprise an illumination source, a tunable filter, and a detector configured to generate a test Raman data set representative of a biological sample.04-05-2012

Patent applications in class Infrared, visible light, or ultraviolet radiation directed on or through body or constituent released therefrom

Patent applications in all subclasses Infrared, visible light, or ultraviolet radiation directed on or through body or constituent released therefrom