Class / Patent application number | Description | Number of patent applications / Date published |
570143000 | Preparing benzene ring containing compound | 15 |
20080214878 | Method For The Production Of 1,3,5-Trifluoro-2,4,6-Trichlorobenzene From Fluorobenzene Derivatives - Method for the production of 1,3,5-trifluoro-2,4,6-trichlorobenzene from fluorobenzene comprising steps A) and B): A) chlorination of fluorobenzene derivatives of formula (II), in which X=fluorine of H, Z=nitro, bromo or chloro and n=0 or 1-4 and B) fluorination of the distillation residue and separation by distillation of the 1,3,5-trifluoro-2,4,6-trichlorobenzene thus produced. | 09-04-2008 |
20080262274 | PROCESSES FOR PRODUCING CHLOROFLUOROCARBON COMPOUNDS USING INORGANIC FLUORIDE - Methods and systems for producing chlorofluorocarbon with an inorganic fluoride (e.g., germanium tetrafluoride (GeF | 10-23-2008 |
20080262275 | PROCESSES FOR PRODUCING HALOCARBON COMPOUNDS USING INORGANIC FLUORIDE - Methods and systems for producing halocarbon with an inorganic fluoride (e.g., germanium tetrafluoride (GeF | 10-23-2008 |
20090036718 | USE OF A COMPOSITION OF AN IONIC NATURE AS A SUBSTITUTION REAGENT, A COMPOSITION CONSTITUTING A FLUORINATION REAGENT AND A METHOD USING SAME - The invention relates to processes for aromatic nucleophilic substitution by contacting a substrate of formula (III) | 02-05-2009 |
20090076315 | PROCESS FOR THE PREPARATION OF SUBSTITUTED FLUORENES - Methods for the preparation of fluorenyl-type ligand structures and substituted fluorenyl groups which may be employed in metallocene-type olefin polymerization catalysts. There is provided a 2,2′-dihalogen-diphenylmethylene having a methylene bridge connecting a pair of phenyl groups. Each phenyl group has a halogen on a proximal carbon atom relative to the methylene bridge. The halogenated diphenylmethylene is reacted with a coupling agent comprising a Group 2 or 12 transition metal in the presence of a nickel or palladium-based catalyst to remove the halogen atoms from the phenyl groups and couple the phenyl groups at the proximal carbon atoms to produce a fluorene ligand structure. The coupling agent may be zinc, cadmium or magnesium and the catalyst may be a monophosphene nickel complex. The halogenated diphenylmethylene may be an unsubstituted ligand structure or a monosubstituted or disubstituted ligand structure. The halogenated diphenylmethylene may be monosubstituted with a tertiary butyl group or may be a dialkyl diphenylmethylene having alkyl substituents at the directly distal positions of the phenyl groups relative to the methylene bridge. | 03-19-2009 |
20090171131 | METHOD FOR PRODUCING 1,4-BIS (DICHLOROMETHYL) TETRAFLUOROBENZENE - A method for producing 1,4-bis(dichloromethyl)tetrafluorobenzene is disclosed, which is achieved by reacting tetrafluoroterephthaldehyde, SOCl | 07-02-2009 |
20110065968 | PROCESS FOR THE PRODUCTION OF SUBSTITUTED BROMOBENZENES - The present invention relates to a process for the production of compounds of formula (I) wherein X is fluoro, chloro, bromo or iodo and n is 1, 2, 3 or 4, which process comprises reacting a compound of formula (II) wherein the substituents are as defined for formula (I), with inorganic nitrite in an acidic aqueous medium in the presence of bromide and a copper catalyst and wherein the process is carried out as a one-pot reaction. | 03-17-2011 |
570144000 | Haloalkyl containing compound | 4 |
20120330072 | METHOD FOR PRODUCING SUBSTITUTED FLUORINE-CONTAINING OLEFIN - This invention relates to a method of reacting fluoroolefin with an organic magnesium compound in the presence of a catalyst comprising nickel or palladium so as to efficiently produce fluoroolefin, such as TFE, in which a fluorine (F) atom or atoms bonded to the sp | 12-27-2012 |
20130116482 | FACILE AND EFFECTIVE METHOD OF PREPARING 1,4-BIS(CHLORODIFLUOROMETHYL)BENZENE - The present invention relates to a facile method of preparing 1,4-bis(chlorodifluoromethyl)benzene, comprising the steps of: (A) providing a reactant liquid of 1,4-bis(difluoromethyl)benzene; optionally (B) providing a light source for UV radiation; and (C) introducing chlorine gas into the reactant liquid at a temperature of 50-90° C. under a pressure above 1 atm to obtain 1,4-Bis(chlorodifluoromethyl)benzene. The invented facile method can be utilized in a batch process or a continuous process for effective production of 1,4-bis(chlorodifluoromethyl)benzene. | 05-09-2013 |
20130131401 | PROCESS FOR THE PREPARATION OF CHYMASE MODULATORS - The present invention is a process for the preparation of chymase modulators, useful in the treatment of inflammatory and serine protease mediated disorders. | 05-23-2013 |
20140357906 | FLUORINE-CONTAINING AROMATIC COMPOUND AND MANUFACTURING METHODTHEREFOR - A method of manufacturing a fluorine-containing aromatic compound represented by the following formula (2-1) or formula (2-2): [R is a hydrogen atom, an alkyl group having a carbon number of 1 to 12 which may have a substituent other than a fluorine atom, or a monovalent aromatic group which may have a substituent; Rf | 12-04-2014 |
570147000 | Substituting halogen for different halogen or hydrogen | 4 |
20080319239 | Method For Substituting Indenofluorenes - The invention relates to a process for the preparation of trans-indenofluorene compounds of the formula (Ia) or cis-indenofluorene compounds of the formula (Ib) | 12-25-2008 |
20090171132 | METHOD FOR PRODUCING 1,4-BIS(DIFLUOROMETHYL)TETRAFLUOROBENZENE - A method for producing 1,4-bis(difluoromethyl)tetrafluorobenzene is disclosed, which has the following steps: (a) mixing 1,4-bis(dichloromethyl)tetrafluorobenzene, a catalyst, an aprotic polar solvent, and an alkali metal fluoride to form a reaction mixture; (b) heating the reaction mixture; and (c) purifying the resultant to obtain 1,4-bis(difluoromethyl)tetrafluorobenzene. | 07-02-2009 |
20100152502 | METHODS FOR SILVER-PROMOTED FLUORINATION OF ORGANIC MOLECULES - The methods of the disclosure may be used for the fluorination of organic compounds, and in particular aryl organic compounds other than just benzyl halogens. It is within the scope of the present disclosure, for organic compounds comprising an electrophilic carbon atom and a halogen leaving group to be fluorinated by the methods of the disclosure. One aspect of the disclosure provides methods of introducing a fluorine atom onto an electrophilic carbon atom, comprising mixing an insoluble basic silver salt, an organic molecule containing a leaving group, an aqueous solution of hydrofluoric acid, and a polar solvent:water composition; incubating said mixture at a temperature of about 20° C. to about 35° C., thereby obtaining a fluorinated organic product. | 06-17-2010 |
20100228060 | PERFLUORO-ARYLIODONIUM SALTS IN NUCLEOPHILIC AROMATIC 18F-FLUORINATION - The present invention describes using fluorous chemistry in n.c.a. nucleophilic aromatic 18F-fluorination reactions by using perfluoro-aryliodonium salts as a precursor for aromatic nucleophilic substitution using a [18F] F-anion to displace a suitable leaving group from an electron deficient benzene ring. The results showed that using perfluoro-aryliodonium salts as a precursor is a suitable leaving group for n. c. a. nucleophilic aromatic 18F-fluorination in synthesis. The PT-precursor seems to be quite stable. In an attempt to purify the crude 18F-labeled product using fluorous solid phase extraction (F-SPE), the radio labeled impurities decreased significantly. Thus, it is possible to use this PT methodology to simplify and speed up purification methods. | 09-09-2010 |