Class / Patent application number | Description | Number of patent applications / Date published |
564133000 | Preparing directly by amidation of -C(=O)X group, where X is O- or halogen | 44 |
20100036162 | Process for the synthesis of agomelatine - Process for the industrial synthesis of the compound of formula (I) | 02-11-2010 |
20110034729 | FLUORINE-CONTAINING POLYETHER COMPOUND AND PROCESS FOR PRODUCING THE SAME - A fluorine-containing polyether compound having the following general formula: | 02-10-2011 |
564134000 | Of carboxylic acid ester | 21 |
20080249334 | Method of Manufacturing 3-(4-Hydroxyphenyl)Propanoic Acid Amide, Its Application in the Manufacture of Anti-Aging Compositions and Anti-Aging Composition - The subjects of the present invention are a method of manufacturing 3-(4-hydroxyphenyl)propanoic acid amide, its application in the manufacture of anti-aging compositions and an anti-aging composition. As phloretamide possesses a series of biological properties it might be use as a composition for skin having excellent anti-aging effect to prevent the sagging of skin and loss of luster. | 10-09-2008 |
20110021820 | Preparation of Hydroquinone Amide Compounds with Antioxidant Properties - The present invention relates to the preparation of compounds of formula (I) derived from arylacetic acid comprising two phenol functions and an amide function, which have free-radical scavenging and antioxidant properties and which are soluble in lipid media. These compounds can be used as cosmetic and pharmaceutical preparations for the prevention of biological degradations caused by free radicals. | 01-27-2011 |
20110178339 | PROCESS FOR MANUFACTURING N, N-DIALKYL LACTAMIDE - A process for manufacturing dialkyl lactamide including reacting lactide and dialkylamine selected from one or more of dimethylamine, diethylamine, and methylethylamine to form a reaction mixture which includes dialkyl lactamide selected from N,N-dimethyl lactamide, N,N-diethyl lactamide, and N,N-methylethyl lactamide, N,N-dialkyl lactoyl lactamide, and dialkylamine, subjecting the reaction mixture to a separation step to form a product stream including N,N-dialkyl lactamide, a first recycle stream including dialkylamine and a second recycle stream including N,N-dialkyl lactoyl lactamide, feeding the recycle streams to the reaction step, and isolating the product stream. The process allows the manufacture of N,N-dimethyl lactamide, N,N-diethyl lactamide, and N,N-methylethyl lactamide on a commercial scale. | 07-21-2011 |
20110224459 | Beta-hydroxyalkylamides, a method for production of same and use of same - The invention relates to new β-hydroxyalkylamides, to a method for production of same and to the use of same. | 09-15-2011 |
20110295036 | METHOD FOR SYNTHESIS OF (1S, 2R)-MILNACIPRAN - The present invention relates to a method for synthesizing a pharmaceutically acceptable acid addition salt of (1S, 2R)-milnacipran comprising the following successive steps: (a) reaction of phenylacetonitrile and of (R)-epichlorhydrin in the presence of a base containing an alkaline metal, followed by a basic treatment, and then by an acid treatment in order to obtain a lactone; (b) reaction of said lactone with MNEt | 12-01-2011 |
20110313195 | METHOD FOR CONTINUOUSLY PRODUCING ALKYLAMINO(METH)ACRYLAMIDES - The invention relates to a process for continuously preparing N-alkyl(meth)acrylamides by reacting alkyl (meth)acrylates with high-boiling amines. A catalyst activation and specific workup technique achieve product qualities which have not been achieved to date. In addition, very high space-time yields and overall yields can be achieved. | 12-22-2011 |
20130172618 | PROCESS FOR THE PREPARATION OF 4-IODO-3-NITROBENZAMIDE - A process for the preparation of 4-iodo-3-nitrobenzamide free from the impurities formed due to nucleophilic substitution of the labile iodo group is disclosed. | 07-04-2013 |
20140200367 | Synthesis of N1,N3-BIS(2,3-DIHYDROXYPROPYL)-5-NITROISOPHTHALAMIDE - The present disclosure generally relates to a new process for the preparation of high purity 5-nitro-isophthalamide compounds, which are useful as intermediates for the preparation of imaging agents, such as iodinated x-ray contrast imaging agents like ioversol, iohexyl and iopamidol. | 07-17-2014 |
20140213821 | CHEMICAL PROCESS FOR OPENING RING COMPOUNDS - It is described a process for the opening of lactone or lactam rings useful in the synthesis of pharmaceutically active compounds and the intermediates thereof, particularly Aliskiren. It has found that by selecting a type of solvent it is possible to obtain excellent yields and high optical and chemical purity of the isolated products. | 07-31-2014 |
564135000 | Having acyclic acid moiety | 12 |
20080234515 | Process for making a (meth)acrylamide monomer - A method for making a (meth)acrylamide monomer, comprises reacting a (meth)acrylate ester with an amino-functional compound in an organic solvent in the presence of a transesterification catalyst. | 09-25-2008 |
20100298604 | PROCESS FOR PRODUCING ALIPHATIC CARBOXYLIC ACID AMIDE - The present invention relates to a process for producing an aliphatic carboxylic acid amide, including the step of reacting an aliphatic carboxylic acid or an alkyl ester thereof containing an alkyl group having 1 to 4 carbon atoms with a mono- or dialkylamine containing an alkyl group or groups having 1 to 4 carbon atoms in the presence of a solid acid catalyst containing titanium oxide as a main component and an oxide or oxides of at least one element selected from elements (except titanium) belonging to Groups 4, 5 and 14 of the long form of the periodic table, wherein the catalyst has an average particle diameter of 2 μm or more. The process for producing an aliphatic carboxylic acid amide according to the present invention has a high reaction efficiency of the reaction of the aliphatic carboxylic acid or alkyl ester thereof with the mono- or dialkylamine, and shows an excellent filtration efficiency in separation of the catalyst. | 11-25-2010 |
20110112327 | PREPARATION OF N-SUBSTITUTED ISOTHIAZOLINONE DERIVATIVES - Provided is a process for the preparation of an N-substituted isothiazolinone derivative having the general formula (I), comprising reacting N-substituted 3-mercaptopropionamides of formula (II) or N,N′-bis-substituted 3,3′-dithiodipropionamides of formula (III) with sulfuryl chloride in the absence of solvents. Also provided is a process for the preparation of a compound having the general formula (III), comprising reacting a methyl ester of formula (IV) with an amine of formula (V) in a solvent of methanol. As no addition solvent is used in the process of the invention, the cost of manufacturing and pollution to the environment can be reduced. | 05-12-2011 |
20140066655 | PROCESS FOR PREPARING N-H OR N-ALKYL 2-PROPYNAMIDE - Disclosed is a method for the synthesis of N—H or N-alkyl 2-propynamides useful as intermediate in the manufacture of pharmaceutically active ingredients. | 03-06-2014 |
20140364649 | METHOD FOR PRODUCING HIGH-PURITY CERAMIDE - Provided is a method for producing an optically active ceramide by an N-acylation (amidation) reaction of an optically active aminodiol, wherein a crude ceramide produced therein is purified by an industrially advantageous process. Namely, provided is a method for producing a high-purity ceramide that has high diastereo purity with high yield. A high-purity ceramide is produced by: a step wherein a ceramide represented by general formula (1) is produced by reacting an aminodiol with an alkyl ester having 1-5 carbon atoms of an aliphatic carboxylic acid having 12-24 carbon atoms, said aliphatic carboxylic acid optionally having a hydroxyl group, in a hydrocarbon solvent having 5-10 carbon atoms; and a step wherein an alcohol having 1-3 carbon atoms is added into the reaction mixture obtained in the preceding step, thereby causing crystals to precipitate. | 12-11-2014 |
564136000 | Additional oxygen in the acid moiety | 7 |
20100076223 | METHOD FOR PRODUCING A BETA-ALKOXYPROPIONAMIDE - A method for producing a β-alkoxypropionamide shown by the following formula (I) including the step of reacting a β-alkoxypropionic acid ester with an amine in the presence of a basic catalyst or in the presence of a basic catalyst and a polyol: | 03-25-2010 |
20110060164 | METHOD FOR THE PREPARATION OF 4-FLUORO-ALPHA-[2-METHYL-1-OXOPROPYL]-GAMMA-OXO-N-BETA-DIPHENYLBENZENEBUT- ANAMIDE AND PRODUCTS THEREFROM - A method for the preparation of 4-fluoro-α-[2-methyl-1-oxopropyl]-γ-oxo-N-β-diphenylbenzenebutanamide also known as 2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-pentanoic acid phenylamide of the formula I containing about 0.1% or less of α-[2-methyl-1-oxopropyl]-γ-oxo-N-β-diphenylbenzene butanamide, about 0.05% or less of difluoro-α-[2-methyl-1-oxopropyl]-γ-oxo-N-β-diphenylbenzene butanamide and about 0.1% or less of 3-[2-(4-Fluorophenyl)-2-oxo-1-phenyl-ethoxy]-4-methyl-pent-2-enoic acid phenylamide. | 03-10-2011 |
20110251430 | METHOD FOR PRODUCING BETA-ALKOXYPROPIONAMIDE - A method for producing a β-alkoxypropionamide including:
| 10-13-2011 |
20120330061 | PREPARATION METHOD OF N,N'-DIALKYL-3,3'-DITHIODIPROPIONAMIDE - This disclosure relates to a method for preparing N,N′-dimethyl-3,3′-dithiodipropionamides, which is an intermediate compound used for preparation of substituted 3-isothiazolones, including reacting 3,3′-dithiopropionic acid alkyl ester with an alkylamine at a temperature of from 0 to 50° C. in the presence of a polar solvent. | 12-27-2012 |
20140018577 | Process for Preparing Lacosamide - The present invention provides a process for the preparation of lacosamide in substantially optically pure form, which in one aspect comprises the following steps: (i) resolution of O-methyl-D,L-serine to provide O-methyl-D-serine in substantially optically pure form; (ii) acetylation of O-methyl-D-serine thereby obtained to provide the N-acetyl 10 derivative thereof in substantially optically pure form; (iii) activating the carboxy group of the compound thereby obtained; and (iv) reacting the compound thereby obtained with benzylamine. | 01-16-2014 |
20150119604 | METHOD FOR PRODUCING BETA-ALKOXYPROPIONAMIDE - A method for producing a β-alkoxypropionamide including reacting a β-alkoxypropionic acid ester represented by the following formula (1) and an amine represented by the following formula (2) in the presence of a polyol and a basic catalyst, thereby to produce a β-alkoxypropionamide represented by the following formula (3),
| 04-30-2015 |
20160039744 | Process for Preparing Lacosamide - The present invention provides a process for the preparation of lacosamide in substantially optically pure form, which in one aspect comprises the following steps: (i) resolution of O-methyl-D,L-serine to provide O-methyl-D-serine in substantially optically pure form; (ii) acetylation of O-methyl-D-serine thereby obtained to provide the N-acetyl 10 derivative thereof in substantially optically pure form; (iii) activating the carboxy group of the compound thereby obtained; and (iv) reacting the compound thereby obtained with benzylamine. | 02-11-2016 |
564138000 | Of carboxylic acid | 14 |
20090069599 | PROCESS FOR PRODUCING TRICARBOXYLIC ACID TRIS (ALKYL-SUBSTITUTED CYCLOHEXYLAMIDE) - Disclosed are, for example, a process for producing a tricarboxylic acid tris(alkyl-substituted cyclohexylamide), the process comprising subjecting a tricarboxylic acid and an alkyl-substituted cyclohexylamine to an amidation reaction, either (a) in the presence of a boric acid compound and a phenol compound or (b) in the presence of a boric acid ester obtained by the dehydration condensation of a boric acid compound and a phenol compound, and optionally purifying the resulting crude reaction product. | 03-12-2009 |
20100130781 | METHOD FOR THE PRODUCTION OF N,N-DIMETHYLACETAMIDE (DMAC) - A process for preparing N,N-dimethylacetamide (DMAC) by continuously reacting methyl acetate (MeOAc) with dimethylamine (DMA) in the presence of a basic catalyst, wherein MeOAc is used in the form of a methanolic solution and the continuous distillative workup is effected in such a way that methanol and any other low boilers are initially removed overhead in a column A and the bottom effluent of column A is fed to a column B in which DMAC is removed via a side draw a purity of ≧99.7% by weight. | 05-27-2010 |
20110004018 | PROCESS FOR PRODUCING DIAMINE AND POLYAMIDE - A method for producing a diamine includes purifying a diamine from an aqueous solution containing a diamine salt by adding an alkaline substance to the aqueous solution and then filtering the resulting solution by allowing the solution to pass through a nanofiltration membrane to remove the salt, thereby obtaining an aqueous diamine solution. | 01-06-2011 |
20130131381 | METHOD FOR PRODUCING POLYAMIDE - A process for the manufacture of polyamide is described. Also described, is a process comprising a stage of initial polymerization under pressure starting from monomers and a stage of finishing in the liquid phase at atmospheric pressure. The finishing stage can employ an injection of inert gas along a direction essentially parallel to that of the flow of the liquid reaction stream. | 05-23-2013 |
20150080607 | AMIDES, USE OF AMIDES AS SOLVENTS FOR ORGANIC COMPOUNDS, COMPOSITIONS AND EMULSIONS CONTAINING AMIDES, AND METHOD FOR TREATING A PLANT - The present invention relates in general to the use of amides of the following general formula (I) wherein R | 03-19-2015 |
564139000 | Benzene ring containing | 9 |
20100036163 | Process for the synthesis of agomelatine - Process for the industrial synthesis of the compound of formula (I) | 02-11-2010 |
20100081843 | Method For Producing Tertiary Amides Of Alkylphenyl Carboxylic Acids - The invention relates to a method for producing tertiary amides of alkylphenyl carboxylic acids by reacting at least one secondary amine with at least one alkylphenyl carboxylic acid to form an ammonium salt, said ammonium salt being subsequently converted into the tertiary amide by means of microwave radiation. | 04-01-2010 |
20100130782 | AMIDATION PROCESS FOR THE PREPARATION OF CATHEPSIN K INHIBITORS - This invention describes an amidation process whereby amino acids of the Formulae IIA or IIB can be activated and treated with an amine in the presence of a base to yield amides of the Formula (I), without loss of optical purity. | 05-27-2010 |
20100331575 | Processes For The Preparation Of Optically Active Intermediates - This invention relates to processes for the production of optically active 2-(disubstituted aryl)cyclopropylamine compounds and optically active 2-(disubstituted aryl)cyclopropane carboxamide compounds which are useful intermediates for the preparation of pharmaceutical agents, and in particular the compound [1S-(1α,2α,3β(1S*,2R*),5β)]-3-[7-[2-(3,4-difluorophenyl)-cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)-cyclopentane-1,2-diol. | 12-30-2010 |
20110137081 | Continuous Method For Producing Amides Of Low Aliphatic Carboxylic Acids - The invention relates to a continuous method for producing amides, according to which at least one carboxylic acid of formula (I) | 06-09-2011 |
20110313196 | NOVEL PROCESS - The present invention relates to a process for the preparation of benzamide derivatives which are useful as intermediates in the preparation of pharmaceutically active compounds. | 12-22-2011 |
20130041180 | PROCESS FOR PREPARING (R)-2-ACETAMIDO-N-BENZYL-3-METHOXY-PROPIONAMIDE - Processes for preparing and purifying (R)-2-acetamido-N-benzyl-3-methoxy-propionamide of formula-1 and intermediates thereof are provided. | 02-14-2013 |
20130190533 | PROCESS FOR THE PREPARATION OF AMINO ACID DERIVATIVES - The present invention relates to a process of manufacture of compounds of formula (B) wherein R | 07-25-2013 |
20150025274 | PROCESSES FOR THE PREPARATION OF (R)-2-ACETAMIDO-N-BENZYL-3-METHOXYPROPIONAMIDE AND INTERMEDIATES THEREOF - This invention relates to processes for the preparation of (R)-2-acetamido-N-benzyl-3-methoxypropionamide (I) and intermediates thereof. Formula (I). | 01-22-2015 |
564142000 | Of carboxylic acid halide | 3 |
20160185711 | Process and Device for Recycling Waste Acid Produced in Process of Producing Zoalene - A process and a device for recycling waste acid produced in the process of producing Zoalene. The process comprises steps: heating, depressurizing and distilling the waste acid recycled after nitration reaction; collecting acid liquid A and distilled water A; mixing the acid liquid A with new concentrated sulfuric acid in proportion, and putting the mixture to a new Zoalene nitration reaction process; and putting the distilled water A into a diluting pot for diluting the liquid produced in the nitration reaction. The waste acid produced in the process of producing Zoalene is recycled and not directly discharged; water resources are recycled, waste of the water resources is reduced, and discharge of waste water produced in the process of producing Zoalene is greatly reduced, so that not only production cost is saved, but also environment pressure is reduced. | 06-30-2016 |
564143000 | Acyclic | 2 |
20100210875 | Novel Compound, Synthesis Method Thereof, and Oil Additive - Problem: To provide a novel compound capable of preventing pyrolysis of fluorinated oils when it is used as an additive for the fluorinated oils. | 08-19-2010 |
20160176805 | Process for Manufacturing Haloacetamides | 06-23-2016 |
564144000 | Of acyclic carboxylic acid anhydride | 4 |
20100048951 | PROCESSES FOR PRODUCING N-ALKYL (ALKYL)ACRYLAMIDES - Methods of producing the N-alkyl(alkyl)acrylamides. In a general embodiment, the present disclosure provides a method of producing an N-alkyl (alkyl)acrylamide comprising providing an aqueous solution comprising an N-alkyl amine and adding to the aqueous solution a base and an (alkyl)acrylic anhydride to form a precipitated N-alkyl(alkyl)acrylamide. | 02-25-2010 |
20120165572 | NOVEL COMPOUND AND METHOD FOR PREPARING THE SAME - The invention is directed to a compound represented by the Formula (1) as defined herein, and a method for preparing a compound represented by the Formula (1) which includes: reacting a diamine compound represented by the Formula (2) as defined herein with a methacrylic anhydride or an acrylic anhydride under a condition where an organic acid having a pKa of 2.0 or more is present in an amount of 0.5 to 5.0 moles based on 1 mole of the diamine compound to obtain a reaction mixture; adding phosphoric acid to the reaction mixture; and purifying the reaction mixture by extraction with an organic solvent. | 06-28-2012 |
20120330062 | PROCESS FOR THE SYNTHESIS OF (7-METHOXY-1-NAPHTHYL) ACETONITRILE AND APPLICATION IN THE SYNTHESIS OF AGOMELATINE - Process for the industrial synthesis of the compound of formula (I) | 12-27-2012 |
20140288330 | PROCESS FOR PREPARING N-ALKYL(METH)ACRYLAMIDES - The invention relates to a process for preparing N-alkyl(meth)acrylamides by reacting (meth)acrylic anhydride with corresponding alkylamines. | 09-25-2014 |