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Phosphorus esters (i.e., compounds having the phosphorus ester group, wherein trivalent or pentavalent phosphorus and carbon are bonded directly to the same divalent chalcogen, and wherein the carbon may be single bonded to any atom but may be multiple bonded only to carbon)

Subclass of:

558 - Organic compounds -- part of the class 532-570 series

558000000 - ORGANIC COMPOUNDS (CLASS 532, SUBCLASS 1)

Patent class list (only not empty are listed)

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Class / Patent application numberDescriptionNumber of patent applications / Date published
558070000 Phosphorus esters (i.e., compounds having the phosphorus ester group, wherein trivalent or pentavalent phosphorus and carbon are bonded directly to the same divalent chalcogen, and wherein the carbon may be single bonded to any atom but may be multiple bonded only to carbon) 88
558072000 Boron containing 1
20120010424LPA Receptor Agonists and Antagonists - Disclosed are compounds according to formula (I) as well as pharmaceutical compositions which include those compounds. Also disclosed are methods of using such compounds, which have activity as agonists or as antagonists of LPA receptors; such methods including treating cancer, producing radioprotection and/or radiomitigation, enhancing cell proliferation, treating a wound, treating apoptosis or preserving or restoring function in a cell, tissue, or organ, culturing cells, preserving organ or tissue function, and treating a dermato logical condition.01-12-2012
558073000 The phosphorus is in a ring 14
20110124899METHOD FOR PREPARING COMBRETASTATIN - The Invention relates to a method for preparing a combretastatin (A): formula (I) in the form of a base or of an addition salt with an acid, which comprises coupling, in the presence of a base and of T3P, the salt of the (Z)-amino compound of formula (II) with a doubly protected L-serine derivative of formula (III) in which PG denotes a group protecting the amine function, so as to obtain the compound of formula (Z)-(Ib): formula (IV), then deprotecting and opening the ring of (Z)-(Ib) in the presence of an acid, so as to obtain the combretastatin (A) in the form of a salt; and, optionally, adding a base, so as to obtain the combretastatin (A) in the form of a base, the salt of the (Z)-amino compound having been obtained by enrichment of the salt of the amino compound of formula (V) in (Z) isomer.05-26-2011
558076000 Additional phosphorus containing ring 5
20080287701BISBIPHENYLACYLPHOSPHINE OXIDE AND PREPARATION METHOD THEREFORE - A bisbiphenylacylphosphine oxide of formula (I) and its preparation method are provided. The formula of —Ar— is11-20-2008
20120149932PHOSPHORUS-CONTAINING COMPOUNDS USEFUL FOR MAKING HALOGEN-FREE, IGNITION-RESISTANT POLYMERS - Phosphorus-containing compounds useful for flame retardant epoxy resins are disclosed. The flame retardant epoxy resins may be used to make electrical laminates. This invention is particularly useful in end use applications in which a low bromine or low halogen content is required or desired.06-14-2012
558077000 Phosphorus, and two chalcogens bonded directly thereto, in the same ring (e.g., cyclic phosphonates, etc.) 3
558078000 Acyclic divalent chalcogen single bonded directly to the ring phosphorus (e.g., cyclic phosphites, etc.) 3
20130041171MACROMOLECULAR ANTIOXIDANTS BASED ON STERICALLY HINDERED PHENOLS AND PHOSPHITES - A sterically hindered phenol and phosphite based compound represented by the following formula:02-14-2013
558079000 And divalent chalogen double bonded directly to the ring phosphorus (e.g., cyclic phosphates, etc.) 2
20120264965PROCESSES FOR PRODUCTION OF CYCLIC ALKYLENE PHOSPHOROHALIDITE AND CYCLIC PHOSPHORIC ACID ESTER - A process for producing a cyclic alkylene phosphorohalidite, which comprises reacting a specific phosphorus trihalide with a specific alkylene glycol compound under conditions where the phosphorus trihalide is present in an excess amount relative to the amount of the alkylene glycol compound in the reaction system to order to obtain the cyclic alkylene phosphorohalidite by reacting the alkylene glycol compound with the phosphorus trihalide; and a process for producing a cyclic phosphoric acid ester by using the obtained cyclic alkylene phosphorohalidite as a raw material.10-18-2012
20110207955Process for the production of organic dithiopyrophosphates - Organic dithiopyrophosphates of formula wherein R08-25-2011
558080000 And nitrogen in the ring 1
558081000 And chalcogen or carbon in the ring 1
20110207956INTRAMOLECULAR C-H AMINATION WITH PHOSPHORYL AZIDES - A highly effective Co(II)-based system has been developed for catalytic intramolecular C—H amination with phosphoryl azides without the need of terminal oxidant or other additives, resulting in the high-yielding production of cyclophosphoramidates with nitrogen gas as the by-product; additional features of this new catalytic system include the amination of primary C—H bonds and formation of 7-membered ring structures.08-25-2011
558082000 And carbon and chalcogen in the ring 7
20100105939PHOSPHORUS-CONTAINING COMPOUND AND METHOD FOR PREPARING THE SAME - The present invention provides a phosphorus-containing compound of formula (I):04-29-2010
20100069657METHOD FOR THE PRODUCTION OF DIBENZ[C,E] [1,2]-OXAPHOSPHORIN DERIVATIVES, AMINO-DIBENZ[C,E] [1,2]-OXAPHOSPHORIN AND ALSO USE THEREOF - The invention relates to general syntheses of (6H)-dibenz[c,e] [1,2]-oxaphosphorins which are substituted with nitrogen compounds on the phosphorus atom and comprising commercially available 6H-dibenz[c,e] [1,2]-oxaphosphorin-6-oxides. These nitrogen-containing (6H)-dibenz[c,e] [1,2]-oxaphosphorins can be used as reactive starting substances for further syntheses or as flameproofing agents or as stabilisers.03-18-2010
20110034717METHOD FOR SYNTHESIZING 9,10-DIHYDRO-9-OXA-10-PHOSPHAPHENANTHRENE-10-OXIDE AND DERIVATIVES THEREOF - A method for synthesizing 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide or its derivatives has a step of introducing 6-chloro-6H-dibenz[c,e][1,2]oxaphosphorin or its derivative, an acid compound and water into a reacting chamber to form an organic layer having 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide or its derivative and an aqueous layer. Because the acid compound is from an external source and has a catalyzing effect, employing the method can prevent side reaction from occurring and increase yield of 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide or its derivative. Furthermore, the method is a one-pot operation of hydrolysis, dehydration and cyclization, so the method does not require purification of intermediates. Therefore, the method is time-and cost-saving and requires less organic solvent, resulting in less pollution to the environment.02-10-2011
558083000 Plural chalcogens in the ring 4
20090326256ANALGESIC AGENT COMPRISING CYCLIC PHOSPHATIDIC ACID DERIVATIVE - An object of the present invention is to elucidate an analgesic effect as one of new cPA bioactivities and thus to provide a novel analgesic agent. The present invention provides an analgesic agent which comprises a cyclic phosphatidic acid derivative that is one type of phospholipid.12-31-2009
558084000 The ring phosphorus is attached directly to halogen or an acyclic nitrogen by nonionic bonding 2
20110201837METHOD FOR PRODUCING 6-CHLORODIBENZO[D,F] [1,3,2]DIOXAPHOSPHEPIN - The invention relates to a method for producing 6-chlorodibenzo[d,f] [1,3,2]-dioxaphosphepin (formula 1), comprising the following steps: a) addition of liquid 2,2′-dihydroxybiphenyl into a reactor to an excess of phosphorous trichloride under inert gas and stirring; b) discharge and neutralization of the resulting gases from the reaction mixture; c) separation of the excess phosphorous trichloride; d) obtention of 6-chlorodibenzo[d,f] [1,3,2]-dioxaphosphepin.08-18-2011
20130172596PROCESS FOR PREPARING 6-CHLORODIBENZO[D,F][1,3,2]DIOXAPHOSPHEPIN - The present invention relates to a process for preparing 6-chlorodibenzo[d,f][1,3,2]dioxaphosphepin (I)07-04-2013
558085000 Acyclic divalent chalcogen single bonded directly to the ring phosphorus (e.g., cyclic phosphites, etc.) 1
558086000 And divalent chalcogen double bonded directly to the ring phosphorus (e.g., cyclic phosphates, etc.) 1
20130072708PHOSPHORIC ACID ESTER PRODUCTION METHOD - The present invention provides a novel production method which enables obtain a phosphorus compound having both an aromatic substituent and a phosphorinane backbone, without using an expensive hydrogen halide scavenger, without going through a complicated post treatment step or a step of recovering a solvent, and with a favorable yield andpurity. In the present invention, step (1) of allowing phosphorus oxytrihalide to react with a phenol compound or naphthol compound at a molar ratio of 1.1-3.0:1 in the presence of metal halide, and removing unreacted phosphorus oxytrihalide, to produce a mono-substituted phosphorodihalidate; and step (2) of allowing the mono-substituted phosphorodihalidate obtained in the step (1) to react with a diol compound, at a 0.90 to 0.99 molar equivalent based on 1 mole of the halogen atom in the mono-substituted phosphorodihalidate so as to perform a dehydrohalogenation reaction, to obtain a phosphorus compound represented by Formula (V).03-21-2013
558087000 Processes 52
20100004477NOVEL CRYSTAL OF 5-AMINOLEVULINIC ACID PHOSPHATE AND PROCESS FOR PRODUCING THE SAME - To provide a novel crystal of 5-aminolevulinic acid phosphate having a high thermal stability, a high melting point, and an excellent moisture absorption resistance as well as a process for producing the same.01-07-2010
20100113817PHOSPHORYLCHOLINE GROUP-CONTAINING COMPOUND, METHOD OF MANUFACTURING A PHOSPHORYLCHOLINE GROUP-CONTAINING COMPOUND, SURFACE-MODIFYING AGENT, AND A METHOD OF MODIFYING A SURFACE USING A SURFACE-MODIFYING AGENT - A phosphorylcholine group-containing compound that is a structure having a phosphorylcholine group represented by the following formula 1 and an amino group or a group derived from an amino group in an identical compound.05-06-2010
20100267980CURING ACCELERATOR FOR DEEP-ULTRAVIOLET-TRANSMITTING EPOXY RESIN, DEEP-ULTRAVIOLET-TRANSMITTING EPOXY RESIN COMPOSITION, AND DEEP-ULTRAVIOLET-TRANSMITTING EPOXY RESIN CURED PRODUCT - An object of the present invention is to provide a deep-ultraviolet-transmitting epoxy resin cured product having high heat resistance and high resistance to deep-ultraviolet light, and to provide a curing accelerator and an epoxy resin composition which are used for producing the epoxy resin cured product. The curing accelerator for deep-ultraviolet-transmitting epoxy resins comprises a tetraalkylphosphonium dialkyl phosphate represented by the following general formula (1):10-21-2010
20090054675Process for the alkylation of phosphorus-containing compounds - A process for alkylating a phosphorus-containing compound to provide an alkylated phosphorus-containing compound is provided which comprises alkylating 5 phosphorus-containing compound possessing at least one phosphorus-hydrogen alkylatable site with reactant which generates alkene and/or cycloalkene alkylating agent in situ in the presence of initiator, the alkylene and/or cycloalkylene alkylating agent alkylating the phosphorus-containing component to provide alkylated phosphorus-containing product.02-26-2009
20100261926SURFACE-MODIFIED NANODIAMOND AND ITS PRODUCING METHOD - A surface-modified nanodiamond includes a base nanodiamond, and at least one polyglycerol-chain-containing group present on at least a surface portion of the base nanodiamond, in which the polyglycerol-chain-containing group is represented by following Formula (1):10-14-2010
201203100021,4,6,10-Tetra-Double Bond Pentadec-Carbon Phosphonate, Preparation Method Thereof, And Preparation Method Of Lycopene Using The Same - 1,4,6,10-tetra-double bond pentadec-carbon phosphonate of formula (4), and preparation method thereof are provided. The preparation method comprises: reacting a pseudo ionone of formula (2) with sulfonium salt to prepare a epoxide of formula (9), and then reacting the epoxide of formula (9) with magnesium bromide to prepare a C-14 aldehyde of formula (3); condensing the C-14 aldehyde of formula (3) with tetra-alkyl methylene diphosphonate to obtain 1,4,6,10-tetra-double bond pentadec-carbon phosphonate of formula (4). Furthermore, the preparation method of lycopene via 1,4,6,10-tetra-double bond pentadec-carbon phosphonate of formula (4) is also provided. The present method has the advantages of short route, easily obtained raw materials, and low cost.12-06-2012
20110046407PROCESS FOR PREPARING ALKOXYAMINES RESULTING FROM BETA-PHOSPHORATED NITROXIDES - The invention relates to an improved process for preparing alkoxyamines resulting from β-phosphorated nitroxides corresponding to the formula (I):02-24-2011
20120330048Lycopene Intermediate 1, 3, 6, 10-Tetra-Double Bond Pentadec-Carbon Phosphonate as well as Preparation Method and Use Thereof - The invention relates to a novel important lycopene intermediate 3,7, 11-trimethyl-1,3,6,10-tetraene-dodecyl diethyl phosphonate. A current lycopene intermediate 2,4,6,10-tetra-double bond pentadec-carbon phosphonate is difficult to synthesize. The invention provides a novel intermediate, which has the following synthesis steps of: preparing 2,6,10-trimethyl-3,5,9-undecane triene-1-aldehyde from pseudoionone; preparing 2,6,10-trimethyl-2,5,9-undecane triene-1-aldehyde from the 2,6,10-trimethyl-3, 5,9-undecane triene-1-aldehyde; and subjecting the 2,6,10-trimethyl-2,5,9-undecane triene-1-aldehyde and tetraethyl methylenediphosphonate to condensation reaction to obtain target product. The invention can generate novel intermediate from raw material pseudoionone only by four reactions, thus the reactions are easy to control and great industrial value are achieved.12-27-2012
20120046489PHOSPHORYLCHOLINE GROUP-CONTAINING COMPOUND, METHOD OF MANUFACTURING A PHOSPHORYLCHOLINE GROUP-CONTAINING COMPOUND, SURFACE-MODIFYING AGENT, AND A METHOD OF MODIFYING A SURFACE USING A SURFACE-MODIFYING AGENT - A phosphorylcholine group-containing compound that is a structure having a phosphorylcholine group represented by the following formula 1 and an amino group or a group derived from an amino group in an identical compound.02-23-2012
558089000 Forming the phosphorus ester group 27
558090000 Reactant having halogen attached directly to phosphorus by nonionic bonding 14
20110196166SLURRY PROCESS FOR SYNTHESIS OF BISPHOSPHITES AND SITU USE THEREOF FOR PRODUCING BISPHOSPHITE - The present invention provides a step-wise process for preparation of a bisphosphite. In step (a) the process prepares a phosphoromonochloridite in high yield, by contacting phosphorus trichloride with an aromatic diol in a slurry under reaction conditions and in the presence of a second aromatic diol to produce a mixture comprising the phosphoromonochloridite, the second aromatic diol, and excess PCl3. The slurry comprises less than 5 mole percent of a nitrogen base, and the organic solvent is selected for its low hydrogen chloride solubility. After removing the excess PCl3, a nitrogen base is added to effect condensation of the phosphoromonochloridite with the second aromatic diol to yield the bisphosphite. The invention particularly provides a process for preparing 6,6′-(3,3′,5,5′-tetra-tert-butylbiphenyl-2,2′-diyl)bis(oxy)didibenzo[d,f][1,3,2]dioxaphosphepine by the above route.08-11-2011
20100228045BIOCOMPATIBLE SUSPENSION STABILIZER FOR DISPERSING INORGANIC NANOPARTICLES INTO AQUEOUS SOLUTION - The present invention relates to a suspension stabilizer for dispersing inorganic nanoparticles into aqueous medium. More particularly, the present invention is directed to a biocompatible suspension stabilizer which comprises phosphoryl domain having an affinity to the surface of an inorganic nanoparticle and poly(ethylene glycol) having an affinity to the aqueous medium, and which is prepared by reacting a biocompatible poly(ethylene glycol)-derivatized polymer with phosphine oxide having a leaving group.09-09-2010
20120041222PROCESS THE SYNTHESIS OF BETA GLYCEROL PHOSPHATE - The present invention provides methods for the preparation of beta glycerol phosphate and its salts. In particular, the invention provides efficient methods for the synthesis of beta glycerol phosphate of high purity.02-16-2012
558092000 And reactant having alcoholic or phenolic -XH group, wherein X is chalcogen (and wherein H of -XH may be replaced by substituted or unsubstituted ammonium, or by a Group IA or IIA light metal) 11
20130090490METHOD FOR PRODUCING AROMATIC DIPHOSPHATES - A method for producing an aromatic diphosphate comprising: Step 1 which is a step where a specific aromatic monohydroxy compound having a steric hindrance group at ortho-positions is made to react with phosphorus oxyhalide in the presence of a Lewis acid catalyst and then the unreacted phosphorus oxyhalide is removed under a reduced pressure to give a specific; and Step 2 which is a step where the reaction product obtained in the above step is made to react with a specific aromatic dihydroxy compound in an amount of 0.5 mol to 1 mol of halogen contained in the reaction product in the presence of a Lewis acid catalyst to give a specific aromatic diphosphate.04-11-2013
20130090489CATALYTIC PROCESS FOR PHOSPHO-HALOGENATION OF FLUORINATED ALCOHOLS - A process for manufacturing a polyfluroalkanoyl phosphorodichloridate comprising reacting a polyfluoroalkanol having the general formula R04-11-2013
20120004438Low Triphenylphosphate, High Phosphorous Content Isopropyl Phenyl Phosphates With High Ortho Alkylation - The present invention relates to low triphenyl phosphate, high phosphorous content aryl phosphates with high ortho alkylation that are suitable for use as flame retardant compositions, processes for their preparation, and their use as flame retardants.01-05-2012
558095000 The phosphorus in the reactant is trivalent 2
20130090491PHENOL-FREE PHOSPHITES DERIVATIVES AND PREPARATION THEREOF - The present invention relates to phenol-free phosphites and preparation thereof. The phenol-free phosphites are obtained by reacting biphenol, and phosphorous derivatives with higher aliphatic alcohol via condensation and trans-esterification. The phenol-free phosphites of the present invention can be used as a heat stabilizer for resin so as to enhance the heat resistance of the resin during processing at high temperatures.04-11-2013
558097000 Trivalent phosphorus converted into pentavalent phosphorus 1
20080255381BISBIPHENYLACYLPHOSPHINE OXIDE AND PREPARATION METHOD THEREFORE - A bisbiphenylacylphosphine oxide of formula (I) and its preparation method are provided. The formula of —Ar— is10-16-2008
558098000 And carbon bonded directly to the phosphorus in the phosphorus containing reactant (e.g., methyl phosphonodichloride, etc.) 1
20130023688PHOSPHORUS-CONTAINING COMPOUNDS WITH POLYMERIC CHAINS, AND METHODS OF MAKING AND USING THE SAME - The present invention relates to novel phosphorus-containing compounds with polymeric chains, and methods of making and using the same. In part, subject compositions containing phosphorus-containing compounds with polymeric chains and a therapeutic agent, and methods of making and using the same, are described. Certain of the subject compositions exhibit reverse thermal gelation.01-24-2013
558099000 And divalent chalcogen single bonded directly to the phosphorus in the phosphorus containing reactant (e.g., diethyl phosphorochloridate, etc.) 2
20120184764Process for preparing alkyl phosphates - The present invention relates to a process for preparing tetraalkyl bisphosphates by reacting tetrachlorobisphosphates with alcohols, neutralizing the resultant hydrogen chloride with a base, and isolating the salt formed in the neutralization from the reaction mixture as a solid.07-19-2012
558100000 Nitrogen containing compound utilized (e.g., pyridine, carbamates, urea, etc., utilized as catalysts, proton acceptors, etc.) 1
20130190523Process for the Preparation of Oxidized Phospholipids - Novel synthetic routes, which are highly applicable for industrial preparation of therapeutically beneficial oxidized phospholipids are disclosed. Particularly, novel methods for efficiently preparing compounds having a glycerolic backbone and one or more oxidized moieties attached to the glycerolic backbone, which are devoid of column chromatography are disclosed. Further disclosed are novel methods of introducing phosphorous-containing moieties such as phosphate moieties to compounds having glycerolic backbone and intermediates firmed thereby.07-25-2013
558101000 Nitrogen containing compound utilized (e.g., pyridine, carbamates, urea, etc., utilized as catalysts, proton acceptors, etc.) 3
20120130108PROCESS FOR THE PREPARATION OF OXIDIZED PHOSPHOLIPIDS - Novel synthetic routes, which are highly applicable for industrial preparation of therapeutically beneficial oxidized phospholipids are disclosed. Particularly, novel methods for efficiently preparing compounds having a glycerolic backbone and one or more oxidized moieties attached to the glycerolic backbone, which are devoid of column chromatography are disclosed. Further disclosed are novel methods of introducing phosphorous-containing moieties such as phosphate moieties to compounds having glycerolic backbone and intermediates formed thereby.05-24-2012
20120172613PROCESS FOR MANUFACTURING PHOSPHATE ESTERS FROM PHOSPHORYL CHLORIDE AND MONOALKYL ETHERS OF GLYCOLS OR POLYGLYCOLS - Phosphate ester compounds are prepared by reacting phosphoryl chloride with at least one mono(alkylene glycol) monoether or poly(alkylene glycol) monoether, or a mixture at least one mono(alkylene glycol) monoether or poly(alkylene glycol) monoether and at least one alkylene glycol or polyalkylene glycol, in the presence of at least three moles per mole of phosphoryl chloride of a pyridinyl compound that is devoid of aliphatic nitrogen atoms.07-05-2012
20130158283Process for the Preparation of Oxidized Phospholipids - Novel synthetic routes, which are highly applicable for industrial preparation of therapeutically beneficial oxidized phospholipids are disclosed. Particularly, novel methods for efficiently preparing compounds having a glycerolic backbone and one or more oxidized moieties attached to the glycerolic backbone, which are devoid of column chromatography are disclosed. Further disclosed are novel methods of introducing phosphorous-containing moieties such as phosphate moieties to compounds having glycerolic backbone and intermediates formed thereby.06-20-2013
558104000 Reactant has -XH, wherein X is chalcogen, bonded directly to phosphorus (wherein H of -XH may be replaced by substituted or unsubstituted ammonium, or by a Group IA or IIA light metal) 6
20110046408GELLED HYDROCARBONS FOR OILFIELD PROCESSES, PHOSPHATE ESTER COMPOUNDS USEFUL IN GELLATION OF HYDROCARBONS AND METHODS FOR PRODUCTION AND USE THEREOF - Phosphate esters useful for gelling hydrocarbons in combination with a metal source are disclosed along with methods of preparation of the phosphate esters. Fouling in oil refinery towers has been attributed due to distillation of impurities present in phosphate esters used to gel hydrocarbons for oil well fracturing. The improved method of preparation of the phosphate ester results in a product that substantially reduces or eliminates volatile phosphorus, which is phosphorus impurities that distill up to 250° C., and increases the high temperature viscosity of the hydrocarbon gels formed using the phosphate esters.02-24-2011
558108000 And -C(=X)- containing reactant, wherein X is chalcogen 1
20090124822PROCESS FOR PREPARING MALATHION FOR PHARMACEUTICAL USE - The present invention provides a process for preparing a highly pure form of malathion having a reduced level of toxic impurities. In addition, the malathion prepared by the process of this invention is storage stable. The level of toxic impurities in the malathion, e.g., isomalathion, O,O,S-trimethyl phosphorodithioate (MeOOSPS), O,O,S-trimethyl phosphorothioate (MeOOSPO), O,S,S-trimethyl phosphorodithioate (MeOSSPO), malaoxon, isomalathion, diethyl fumarate, methyl malathion, dimethyl malathion, O,O-methyl,ethyl-S-(1,2-dicarboethoxy)ethyl-phosphorodithioate are lower than that of any other commercial preparation of malathion that may be used for pharmaceutical purposes.05-14-2009
558110000 And reactant having alcoholic or phenolic -XH group, wherein X is chalcogen (and wherein H of -XH may be replaced by substituted or unsubstituted ammonium, or by a Group IA or IIA light metal) 4
20110040116Method For Producing Alkoxylated Phosphoric Acid Triesters - The invention relates to a method for producing phosphoric acid triesters of formula (I). According to said method, phosphoric acid or a phosphoric acid derivative selected from orthophosphoric acid, tetraphosphoric decaoxide and polyphosphoric acid is reacted with alkoxylated alcohols of formulae (II) R02-17-2011
20100063311OLIGOMERIC PHOSPHONATE COMPOSITIONS, THEIR PREPARATION AND USES - This invention provides oligomeric hydrogen phosphonates represented by the formula (I) where R is an alkyl group having one to about six carbon atoms; R′ is a linear or branched hydrocarbylene group or an oxygen-containing hydrocarbylene group having two to about twenty carbon atoms or a hydrocarbylene group having at least one cycloaliphatic or aromatic ring, where at least one of R′ is a linear or branched hydrocarbylene group or an oxygen-containing hydrocarbylene group and at least one of R′ is a hydrocarbylene group having at least one cycloaliphatic or aromatic ring; and n is a number from 2 to about 20. Also provided are processes for making these oligomeric hydrogen phosphonates, oligomeric organophosphonate compositions, and processes for making these oligomeric organophosphonate compositions.03-11-2010
20110237818PROCESS FOR PRODUCTION OF PURIFIED O-(2,6-DICHLORO-4-METHYL-PHENYL) O,O-DIMETHYL PHOSPHOROTHIOATE - A process for producing a purified O—(2,6-dichloro-4-methylphenyl)—O,O-dimethyl phosphorothioate, the process comprising:09-29-2011
20130158284Method For Producing Alkoxylated Phosphoric Acid Triesters - The invention relates to a method for producing phosphoric acid triesters of formula (I). According to said method, phosphoric acid or a phosphoric acid derivative selected from orthophosphoric acid, tetraphosphoric decaoxide and polyphosphoric acid is reacted with alkoxylated alcohols of formulae (II) R06-20-2013
558112000 Reactant consists of phosphorus and sulfur (e.g., phosphorus pentasulfide, etc.) 1
20100204501PROCESS FOR THE PREPARATION OF MALATHION AND ITS INTERMEDIATE - The present invention relates to the improved process for the preparation of highly pure form of S-[1,2-(dicarbethoxy)-ethyl]O,O-dimethyl phosphorodithioate having formula (I). The compound of formula (I) has adopted name “Malathion”. The present invention also relates to the novel process of preparing intermediate O,O-dimethyldithiophosphoric acid of formula (II), which is useful in the preparation of Malathion. The Malathion prepared by the process of this invention is highly storage stable and toxic impurities are much lower than any other commercial preparation available for the pharmaceutical purpose.08-12-2010
558113000 Reactant consists of phosphorus and oxygen (e.g., phosphorus pentoxide, etc.) 5
20120172614METHOD FOR THE MANUFACTURE OF DIALKYL PHOSPHITES - A method for the manufacture of dialkyl phosphites by reacting a P—O component containing from 1 to 6 P—O—P bonds in the molecule, with an alcohol and a ketal corresponding to a selected formula, said ketal will not lead to the formation of an enol structure. The level of the ketal is expressed in relation to the level of co-reactants. A preferred ketal is void of any carbon-hydrogen bonds on the α-carbon atom in the ketal structure.07-05-2012
558114000 And reactant having alcoholic or phenolic -XH group, wherein X is chalcogen (and wherein H of -XH may be replaced by substituted or unsubstituted ammonium, or by a Group IA or IIA light metal) 4
20090187038REAGENTS AND METHODS FOR THE BETA-KETO AMIDE SYNTHESIS OF A SYNTHETIC PRECURSOR TO IMMUNOLOGICAL ADJUVANT E6020 - This invention relates to the synthesis for a precursor of E6020, compound 26, via a β-keto amide alcohol intermediate, compound 22. The synthesis reacts compound 22 with compound 25 and the resultant intermediate is oxidized to produce compound 26, the precursor to E6020. Compounds 22 and 25, and their crystalline forms, represent separate embodiments of the invention. The invention also relates to compounds of formulas (3) and (4) and processes for their preparation.07-23-2009
20120190877METHOD FOR THE MANUFACTURE OF DIALKYLPHOSPHITES - A method for the manufacture of dialkyl phosphites is disclosed wherein a P—O component containing from 1 to 6 P—O—P bonds in the molecule is reacted with an alcohol and a carboxylic acid ester having from 1 to 6 carbon atoms in the alkyl group and from 5 to 20 carbon atoms in the esterifying alkyl group of the ester. The dialkyl phosphites are formed under simultaneous removal by distillation of the carboxylic acid formed.07-26-2012
20120130109PROCESS FOR THE MANUFACTURE OF DIALKYLPHOSPHITES - A process for the manufacture of dialkyl phosphites is disclosed. In detail, dialkyl phosphites are prepared starting from P05-24-2012
20080300418Synthesis of Cardiolipin Analogues and Uses Thereof - The invention provides novel synthetic methodologies for preparing cardiolipin, migrated caridiolipin (1,2-positional isomer of cardiolipin) and their analogues having varying fatty acids and/or alkyl chains with varying length and degrees of saturation/unsaturation. The method comprises (a) reacting an optically pure 1,2-O-dialkyl-sn-glycerol or 1,2-O-dialkyl-sn-glycerol with one or more phosphoramidite reagent(s), wherein a phosphite triester is produced; (b) coupling the product of (a) with glycerol, wherein a protected cardiolipin is produced; and (c) deprotecting the protected cardiolipin, such that cardiolipin is prepared. The cardiolipins and analogues thereof, prepared by the present methods, can be incorporated into liposomes, which can also include active agents such as hydrophobic or hydrophilic drugs, antisense nucleotides or diagnostic agents. Such liposomes can be used to treat diseases or can be used in diagnostic and/or analytical assays.12-04-2008
558115000 Trivalent phosphorus converted into pentavalent phosphorus 1
20110124900DIARYL ALKYLPHOSPHONATES AND METHODS FOR PREPARING SAME - A method for preparing substantially pure optionally substituted diaryl alkylphosphonates from an optionally substituted triarylphosphite and an optionally substituted trialkylphosphite or an optionally substituted alkanol under special reaction conditions is described.05-26-2011
558122000 Trivalent phosphorus converted into pentavalent phosphorus 2
20100179342PROCESS FOR MAKING DIHYDROCARBYL HYDROCARBONPHOSPHONATES - This invention provides a process for the preparation of a dihydrocarbyl hydrocarbonphosphonate. The process comprises forming a reaction mixture from components comprising (i) at least one dihydrocarbyl phosphite, (ii) at least one alkali metal hydrocarbyloxide, and (iii) at least one alcohol, so that a dihydrocarbyl hydrocarbonphosphonate is formed.07-15-2010
558124000 Reactant having halogen bonded directly to carbon (e.g., Arbuzov rearrangement, etc.) 1
558125000 The reactant contains carbon to carbon unsaturation 1
20120029224PROCESS FOR THE PREPARATION OF HALOGENATED ARYL PHOSPHONATES - A process for preparing halogen-substituted aryl phosphonates represented by formula (I): wherein each Hal independently represents halogen; k is 1 or 2; n is an integer between 1 and 5, inclusive; m is an integer between 1 and 3, inclusive; and R is a straight or branched C1-C5 alkyl group which may be optionally substituted with one or more halogen atoms, which process comprises reacting under heating a compound represented by the following formula: wherein X is a leaving group, with trialkyl phosphite of the formula (RO)02-02-2012
558129000 Forming or utilizing an -O-O- or -S-S- group 1
20120238772PROCESS FOR AND INTERMEDIATES IN THE PREPARATION OF CANFOSFAMIDE AND ITS SALTS - A process for and intermediates in the preparation of canfosfamide and its salts. Some of the intermediates have anticancer activity.09-20-2012
558132000 Forming phosphorus to chalcogen bond 2
20120184766Process for preparing alkyl phosphates - The present invention relates to a process for preparing tetraalkyl bisphosphates by reacting tetrachlorobisphosphates with alcohols, neutralizing the resultant hydrogen chloride with a base, and isolating the desired product from the reaction mixture by extraction.07-19-2012
20120184765Process for preparing alkyl phosphates - The present invention relates to a process for preparing tetraalkyl bisphosphates by reacting tetrachlorobisphosphates with alcohols, neutralizing the resultant hydrogen chloride with a base, and isolating the salt formed in the neutralization from the reaction mixture as a solid.07-19-2012
558134000 Substituting carbon for halogen, hydrogen, or metal bonded directly to the phosphorus 1
558137000 Reactant having acyclic or alicyclic carbon to carbon unsaturation 1
20100121092PROCESS FOR PREPARING AN ALKENYLPHOSPHONIC ACID DERIVATIVE - Process for preparing an alkenylphosphonic acid derivative by reacting a phosphonic acid derivative with an alkyne in the presence of a complex catalyst system and a base whose conjugate acid has a pKa in dimethyl sulfoxide (25° C., 1 bar) of at least 6.05-13-2010
558139000 Forming a -C(=X)NHH or -N=C=O group, wherein X is chalcogen and substitution may be made for hydrogen only 1
20100130765LYSINE-BASED PRODRUGS OF ASPARTYL PROTEASE INHIBITORS AND PROCESSES FOR THEIR PREPARATION - The present invention provides processes for synthesizing lysine based compounds of the formula;05-27-2010
558144000 Reactant having halogen or nitrogen attached directly to phosphorus by nonionic bonding 1
20100076212METHOD FOR THE PURIFICATION OF TRIORGANOPHOSPHITES BY TREATMENT WITH A BASIC ADDITIVE - The invention provides a method for separating one or more triorganophosphite components from a crude phosphite mixture containing acidic hydrolysis products, the method comprising: 03-25-2010
558145000 Reactant having nitrogen attached indirectly to phosphorus by nonionic bonding 3
20090270647METHOD FOR PRODUCING ALPHA - AMINO ACID INCLUDING PHOSPHORUS AND PRODUCTION INTERMEDIATES THEREOF - A method for efficiently producing L-2-amino-4-(hydroxymethylphosphinyl)-butanoic acid, useful as a herbicide, by a catalytic asymmetric synthesis reaction with a high asymmetric yield. The method includes a step in which a compound represented by the below formula (1) and a benzylamine are reacted in the presence of dehydrating agent, then the resulting mass is reacted with hydrogen cyanide in the presence of an asymmetric catalyst, followed by acid hydrolysis, further followed by elimination of a protective group. [chemical formula 1] (1) (where, R10-29-2009
20090253926Lysine-based prodrugs of aspartyl protease inhibitors and processes for their preparation - The present invention provides processes for synthesizing lysine based compounds of the formula;10-08-2009
20120059183PHOSPHORYLCHOLINE GROUP-CONTAINING COMPOUND, METHOD OF MANUFACTURING A PHOSPHORYLCHOLINE GROUP-CONTAINING COMPOUND, SURFACE-MODIFYING AGENT, AND A METHOD OF MODIFYING A SURFACE USING A SURFACE-MODIFYING AGENT - A phosphorylcholine group-containing compound that is a structure having a phosphorylcholine group represented by the following formula 1 and an amino group or a group derived from an amino group in an identical compound.03-08-2012
558146000 Purification or recovery 5
20110130586RECOVERY OF MULTIPLE COMPOUNDS AND RECYCLABLE WATER FROM THIN STILLAGE - Methods for recovery of recyclable water and/or fermentation co-products from thin stillage process streams. Microbial metabolites and/or plant derivatives and/or plant extractives are removed from thin stillage after which, recyclable water is recovered from the processed thin stillage. Thin stillage is commingled with one or more polar organic solvents to react microbial metabolites and/or plant derivatives and/or plant extractives with the organic solvents. The reacted organic solvents are then separated from the processed thin stillage. Thin stillage may be commingled with an oil to re act with certain organic compounds, after which, the reacted oil is separated from the processed thin stillage is further extracted with one or more polar organic solvents. Alternatively, thin stillage may be first processed with one or more polar organic solvents, and then processed with an oil. Useful organic compounds may recovered from the reacted oil and from the reacted organic solvents.06-02-2011
20080275265Process for the Preparation of (Aminoalkylamino)Alkyl Halides and Conversion to Amifostine - The present invention relates to processes for the preparation of (ω-aminoalkylamino)alkyl halides, their conversion to S-ω-(ω-aminoalkylamino)alkyl phosphothioates, and purification of the crystalline products of the reaction. The preparation process for the (ω-aminoalkylamino)alkyl halides comprises contacting an appropriate alcohol with a brominating agent in the presence of a sulfone solvent under temperature and pressure conditions suitable to effect salt formation without subsequent premature precipitation. The process is especially useful for converting (ω-aminoalkylamino)ethyl alcohol to amifostine.11-06-2008
558147000 Of compounds having plural phosphori 1
20130225849METHOD OF PURIFYING ORGANIC DIPHOSPHITE COMPOUNDS - The present invention relates to a method of purifying organic diphosphite compounds.08-29-2013
558149000 Oxidation employed to purify or recover 1
20090099383Purification of rosuvatatin intermediate by thin film evaporation and chemical method - Provided are processes for the purification of a pure rosuvastatin intermediate by thin film evaporation and chemical method, and conversion of the intermediate to rosuvastatin or salts thereof.04-16-2009
558150000 Metal containing material utilized or separated 1
20110021803PURIFICATION AND PREPARATION OF PHOSPHORUS-CONTAINING COMPOUNDS - A phosphorus-containing compound is treated with at least one metal compound prior to fractional distillation to collect a purified fraction containing about 20 ppb or less arsenic. The purified phosphorus-containing compounds are useful for preparing electronic materials for electronic semiconductor manufacturing. Suitable metal compounds include salts, oxides and/or sulfides of iron, copper, nickel, cobalt, or zinc.01-27-2011
558152000 Plural phosphori bonded to the same chalcogen (e.g., pyrophosphate esters, etc.) 1
20130190524CYCLITOLS AND THEIR DERIVATIVES AND THEIR THERAPEUTIC APPLICATIONS - The present invention is directed to polyphosphorylated and pyrophosphate derivatives of cyclitols. More particularly, the invention relates to polyphosphorylated and pyrophosphate derivatives of inositols. The invention also relates to compositions of the polyphosphorylated and pyrophosphate derivatives of inositol and other similar, more lipophilic derivatives, and their use as allosteric effectors, cell-signaling molecule analogs, and therapeutic agents.07-25-2013
558155000 Plural phosphori attached directly or indirectly to each other by nonionic bonding 2
558156000 Plural phosphorus ester groups 2
558160000 Having -C(=X)-, wherein X is chalcogen, attached indirectly to phosphorus by acyclic nonionic bonding 1
20130066098Remote Assembly of Targeted Nanoparticles using H-Phosphate ENE/-YNE Hydrophosphonylation Reactions - The present invention provides phosphonate compounds and methods of preparing the phosphonate compounds so as to allow, for example, increased capability to modify nanoparticles for targeted drug delivery applications.03-14-2013
558161000 Divalent chalcogen double bonded directly to pentavalent phosphorus 1
20080319216Salt of a Sulfur-Containing, Phosphorus-Containing Compound, And Methods Thereof - There is disclosed a salt of a sulfur-containing, phosphorus-containing compound. There is also disclosed a method of making the salt.12-25-2008
558166000 Nitrogen attached indirectly to the phosphorus by acyclic nonionic bonding 7
558169000 Chalcogen attached indirectly to the phosphorus by acyclic nonionic bonding 7
20130079540High-Purity Phospholipids - Novel synthetic routes, which are highly applicable for industrial preparation of therapeutically beneficial oxidized phospholipids are disclosed. Particularly, novel methods for efficiently preparing compounds having a glycerolic backbone and one or more oxidized moieties attached to the glycerolic backbone, which are devoid of column chromatography are disclosed. Further disclosed are novel methods of introducing phosphorus-containing moieties such as phosphate moieties to compounds having glycerolic backbone and intermediates formed thereby. Further disclosed is substantially pure 1-hexadecyl-2-(4′-carboxy)butyl-sn-glycero-3-phosphocholine (CI-201).03-28-2013
20100240920PHOSPHATE SURFACTANTS - A compound of Formula 109-23-2010
20120004439COMPOSITION FOR THE PREVENTION AND TREATMENT OF ALOPECIA, OR FOR HAIR GROWTH - Disclosed is a composition for prevention and treatment of alopecia or for hair growth, comprising a phytosphingosine-1-phosphate derivative or a pharmaceutically acceptable salt thereof as an active ingredient. Also, a medicine comprising the composition and a quasi-drug comprising the composition are provided.01-05-2012
20120264966SULFUR-CONTAINING PHOSPHOLIPID DERIVATIVES - The present invention provides a lipid compound comprising at least one non-polar moiety and a polar moiety, wherein each or at least one non-polar moiety is of the formula X—Y—Z, wherein X is a hydrocarbyl chain, Y is selected from at least one of S, Se, SO10-18-2012
20130237720High-Purity Phospholipids - Novel synthetic routes, which are highly applicable for industrial preparation of therapeutically beneficial oxidized phospholipids, are disclosed. Particularly, novel methods for efficiently preparing compounds having a glycerolic backbone and one or more oxidized moieties attached to the glycerolic backbone, which are devoid of column chromatography are disclosed. Further disclosed are novel methods of introducing phosphorus-containing moieties such as phosphate moieties to compounds having glycerolic backbone and intermediates formed thereby. Further disclosed is substantially pure 1-hexadecyl-2-(4′-carboxy)butyl-sn-glycero-3-phosphocholine (CI-201).09-12-2013
558170000 The chalcogen, X, is in a -C(=X)- group, which group is bonded directly to the nitrogen 2
20120283463INTERMEDIATE COMPOUNDS AND PROCESSES FOR THE PREPARATION OF TAPENTADOL AND RELATED COMPOUNDS - The present invention discloses processes for the preparation of 3-[(1R,2R)-3-(dimethyl-amino)-1-ethyl-2-methyl-propyl]phenol (Tapentadol), salts thereof and related compounds of formula (A), including stereoisomers and pharmaceutically acceptable salts thereof, and to certain intermediates used in such process.11-08-2012
558171000 Nitrogen bonded directly to the phosphorus 1
20100197951COMPOUNDS FOR PREPARING IMMUNOLOGICAL ADJUVANT - The present invention provides methods for preparing TLR-4 receptor agonist E6020:08-05-2010
558177000 Chalcogen attached indirectly to the phosphorus by acyclic nonionic bonding 6
20100029973Fatty acid analogues for equilibrating bone mineral density - The invention comprises the use of compounds comprising non β-oxidizable fatty acid entities according to formula (I) or (II) for the preparation of a pharmaceutical composition for the prevention and/or treatment of conditions associated with low/decreased bone mineral density (BMD), and/or for increasing the BMD by decreasing the bone resorption.02-04-2010
558178000 The chalcogen, X, is in a -C(=X)- group 3
558179000 The -C(=X)- is part of a -C(=X)X- group, wherein the X's are the same or diverse chalcogens 3
558180000 Plural -C(=X)X- groups attached indirectly to the phosphorus by acyclic nonionic bonding 3
20090124823PROCESS FOR PREPARING MALATHION FOR PHARMACEUTICAL USE - The present invention provides a process for preparing a highly pure form of malathion having a reduced level of toxic impurities. In addition, the malathion prepared by the process of this invention is storage stable. The level of toxic impurities in the malathion, e.g., isomalathion, O,O,S-trimethyl phosphorodithioate (MeOOSPS), O,O,S-trimethyl phosphorothioate (MeOOSPO), O,S,S-trimethyl phosphorodithioate (MeOSSPO), malaoxon, isomalathion, diethyl fumarate, methyl malathion, dimethyl malathion, O,O-methyl,ethyl-S-(1,2-dicarboethoxy)ethyl-phosphorodithioate are lower than that of any other commercial preparation of malathion that may be used for pharmaceutical purposes.05-14-2009
20090247778Phosphorus-Containing Compounds with Polymeric Chains, and Methods of Making and Using the Same - The present invention relates to novel phosphorus-containing compounds with polymeric chains, and methods of making and using the same. In part, subject compositions containing phosphorus-containing compounds with polymeric chains and a therapeutic agent, and methods of making and using the same, are described. Certain of the subject compositions exhibit reverse thermal gelation.10-01-2009
20100069658STABILIZATION OF DIESTERS OF DICARBONIC ACID - By using phosphorus compounds, diesters of dicarbonic acid may be stabilized against thermal and chemical decomposition over a relatively long period. Mixtures of diesters of dicarbonic acid and phosphorus compounds are outstandingly suitable for preserving foods.03-18-2010
558183000 Plural carbons bonded directly to the same chalcogen which is attached indirectly to the phosphorus by acyclic nonionic bonding (e.g., ethers, etc.) 2
558184000 The chalcogen is part of a -S(=O)- or a -S(=O)(=O)- group (e.g., sulfones, etc.) 1
20090259064SYNTHESIS OF PHOSPHONIC ACID LABELED COMPOUNDS - High purity isotopically labeled phosphonic acid esters can be obtained from isotopically enriched Chloro[10-15-2009
558188000 Halogen attached directly or indirectly to the phosphorus by acyclic nonionic bonding 1
20110257423PROCESS FOR PRODUCING FLUOROELASTOMERS - An emulsion polymerization process for the production of fluoroelastomers is disclosed wherein at least one fluorosurfactant is employed as dispersant, said fluorosurfactant being a fluoroalkylphosphoric acid ester of the formula X—Rf—(CH10-20-2011
558190000 Nitrogen attached indirectly to the phosphorus by nonionic bonding 1
20110251418CASR AGONISTS - By searching various kinds of compounds having CaSR agonistic activity, the present invention provides CaSR agonistic agents, pharmaceutical compositions, preventive or therapeutic agents for diarrhea and kokumi-imparting agents each of which comprise the compound. More specifically, the present invention provides CaSR agonistic agents, pharmaceutical compositions, preventive or therapeutic agents for diarrhea and kokumi-imparting agents each of which comprise a glutamic acid derivative having CaSR agonistic activity or pharmaceutically acceptable salts thereof.10-13-2011
558194000 Chalcogen attached indirectly to the phosphorus by nonionic bonding 1
558195000 Nitrogen or halogen attached directly to the phosphorus by nonionic bonding 1
20130030209PHOSPHINATE RUTHENIUM COMPLEXES - Provided herein are ruthenium complexes of Formula I, and processes of preparation thereof. Also provided are methods of their use as a metathesis catalyst.01-31-2013
558203000 Halogen attached indirectly to the phosphorus by acyclic nonionic bonding 2
20080227997Preparation of phosphorus-containing propoxylation products by using aluminium trichloride - The invention describes a process for preparing propoxylated, phosphorus-containing compounds using aluminium chloride catalyst.09-18-2008
20130274499Synthesis of 2,4-Pyrimidinediamines - Disclosed herein are methods for synthesizing 2,4-pyrimidinediamines as well as intermediates used therein.10-17-2013
558207000 Divalent chalcogen double bonded directly to the phosphorus 1
558214000 And two divalent chalcogens single bonded directly to the phosphorus 1
558215000 Benzene ring bonded directly to one of the chalcogens 1
20130178642METHOD OF PREPARING BIPHENYL-4-YL DIPHENYL PHOSPHATE COMPOSITION - Provided is a method of preparing a biphenyl-4-yl diphenyl phosphate composition for use as a flame retardant or a plasticizer for resin, including mixing phosphoryl chloride (POCl07-11-2013

Patent applications in all subclasses Phosphorus esters (i.e., compounds having the phosphorus ester group, wherein trivalent or pentavalent phosphorus and carbon are bonded directly to the same divalent chalcogen, and wherein the carbon may be single bonded to any atom but may be multiple bonded only to carbon)