Class / Patent application number | Description | Number of patent applications / Date published |
548492000 | Having -C(=X)-, wherein X is chalcogen, bonded directly to ring carbon of the five-membered hetero ring (e.g., indole-2-carboxylic acids, etc.) | 10 |
20090043112 | Process for the Preparation of Enantiomerically Enriched Indoline-2-Carboxylic Acid - The present invention relates to a process for the preparation of an enantiomerically enriched optionally substituted indoline-2-carboxylic acid or a salt thereof, wherein an enantiomerically enriched chiral ortho-X-substituted phenylalanine compound, wherein X is a leaving group, is subjected to cyclisation, preferably at a temperature of below about 140° C., upon formation of the enantiomerically enriched indoline-2-carboxylic acid compound. | 02-12-2009 |
20090069574 | Process for the synthesis of an ace inhibitor - A process for the synthesis of trandolapril which comprises condensing N-[I-(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine N-carboxyanhydride with trans octahydro-1H-indole-2-carboxylic acid in a first organic solvent comprising a water immiscible inert organic solvent and in the presence of a base, and isolating trandolapril from a second organic solvent. N-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine N-carboxyanhydride may also be condensed with (2S,3aR,7aS) octahydro-1H-indole-2-carboxylic acid in a first organic solvent and in the presence of a base, and trandolapril isolated. There is also provided a process for the resolution of racemic trans octahydro-1H-indole-2-carboxylc acid. | 03-12-2009 |
20100056802 | AMORPHOUS FORM OF AN L-ARGININE SALT OF PERINDOPRIL AND PROCESSES FOR PREPARATION THEREOF - In illustrative embodiments, there is provided an amorphous form of L-arginine salt of perindopril which may be particularly suitable for pharmaceutical applications, and processes for preparing said form. | 03-04-2010 |
20110065930 | PROCESS FOR THE SYNTHESIS OF (2S,3AR,7AS)-OCTAHYDRO-1H-INDOLE CARBOXYLIC ACID AS AN INTERMEDIATE FOR TRANDOLAPRIL - A process for the preparation of (2S,3aR,7aS)-octahydro-1H-indole-20carboxylic acid hydrochloride. | 03-17-2011 |
20110144353 | 5-HYDROXY-4-AMINOMETHYL-1-CYCLOHEXANE OR (CYCLOHEPTYL)--3-ALKOXYCARBONYL INDOLE DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE ANTIVIRAL SALTS THEREOF AND A METHOD FOR THE PRODUCTION THEREOF - The invention relates to novel 5-hydroxy-4-aminomethyl-1-cyclohexane or (cycloheptyl)-3-alkoxycarbonyl indole derivatives of general formula (I) and to pharmaceutically acceptable salts thereof exhibiting antiviral activity and to a method for the production thereof. The compounds can be used for treating and/or preventing such viral diseases as pig and bird flu. The invention also relates to a method for producing the compounds of general formula (I), wherein X is hydrogen, chlorine or iodine, n=1 or 2, R | 06-16-2011 |
548493000 | Hydrogen or additional carbon bonded directly to the -C(=X)- group (e.g., aldehydes,ketones, etc.) | 5 |
20100197938 | Process for producing indole compoud - There is provided a novel process for producing an indole derivative which comprises cyclizing 2-nitrobenzylcarbony compound in the presence of a catalyst comprising a Group VIII metal of the Periodic Table, characterized by conducting the cyclization in a gas atmosphere containing carbon monoxide. The process enables an indole compound to be selectively produced in a high yield from 2-nitrobenzylcarbonyl compound, and hardly yields an indoline compound as a reduction by-product that has been a problem in the catalytic hydrogenation method employing a noble metal catalyst. The indole derivative produced by the present process is useful for various fine chemical intermediates including compounds and physiologically active substances such as pharmaceuticals and agrochemicals. | 08-05-2010 |
20140155626 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS - The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators. | 06-05-2014 |
20140378688 | METHOD FOR PRODUCING PYRIDAZINONE COMPOUNDS AND INTERMEDIATE THEREOF - The present invention relates to a novel method for producing a pyridazinone compound and an intermediate
| 12-25-2014 |
20150322009 | NOVEL 3,4,5-TRIMETHOXYSTYRYLARYLAMINOPROPENONES AS POTENTIAL ANTICANCER AGENTS - The present invention relate to compounds of general formula A. The invention also provides the synthesis of 3,4,5-trimethoxystyrylarylaminopropenones useful as potential antitumor agents against human cancer cell lines and a process for the preparation thereof. | 11-12-2015 |
20160024008 | PROCESS FOR PREPARING BENZOFURAN-2-CARBOXAMIDE DERIVATIVES - Provided herein are novel, commercially viable and industrially advantageous processes for the preparation of benzofuran-2-carboxamide derivatives and their intermediates, or a pharmaceutically acceptable salt thereof, in high yield and purity. Provided particularly herein are novel, commercially viable and industrially advantageous processes for the preparation of vilazodone or a pharmaceutically acceptable salt thereof in high yield and purity. Provided also herein is an improved and commercially viable process for the preparation of 3-(4-hydroxybutyl)-1H-indole-5-carbonitrile, in high yield and purity, using novel intermediate compound 3-(4-hydroxybutyryl)-1H-indole-5-carbonitrile. | 01-28-2016 |