| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 548262200 | 1,2,4-triazoles (including hydrogenated) | 40 |
| 20090270633 | Synthesis of 4-[1-(4-cyano phenyl)-(1,2,4-triazol-1-yl)methyl] benzonitrile and 4-[1-(1H-1,2,4-triazol-1-yl)methylene benzonitrile intermediate - The present invention relates to a process for the preparation of 4-[1-(4-cyano phenyl)-1-(1,2,4-triazol-1-yl)methyl]benzonitrile (letrozole), substantially free from its isomeric impurity. The preparation involves reaction of 4-[1-(1H-1,2,4-triazol-1-yl)methylene benzonitrile with 4-fluorobenzonitrile in the presence of an organic solvent and a silicon amine. The present invention also relates to a process for the preparation of 4-[1-(1H-1,2,4-triazol-1-yl)methylene benzonitrile which involves: (a) the reaction of a 4-halomethyl benzonitrile with 1,2,4-triazole in the presence of cesium carbonate and an organic solvent to obtain a reaction mass comprising 4-[1-(1,2,4-triazole-1-yl)methyl]benzonitrile of formula II; and (b) precipitation of 4-[1-(1,2,4-triazole-1-yl)methyl]benzonitrile (II) from the reaction mass using a suitable organic solvent. | 10-29-2009 |
| 20090062550 | Process for the Large Scale Production of Rizatriptan Benzoate - The present invention provides a method for preparing pure Rizatriptan benzoate having purity more than 99.5% and dimer impurity less than 0.1% comprises, i) Condensation of 1,2,4-Triazole with 4-Nitro benzyl bromide to yield 1-(4-nitrophenyl)methyl-1,2,4-triazole ii) Reducing the 1-(4-nitrophenyl)methyl-1,2,4-triazole to give 1-(4-aminophenyl)methyl-1,2,4-triazole iii) Converting 1-(4-aminophenyl)methyl-1,2,4-triazole to 1-(4-hydrazinophenyl)methyl-1,2,4-triazole hydrochloride iv) Condensing the hydrazine derivative with 4-(Dimethylamino) butanal diethylacetal to get Rizatriptan and v) Salification of Rizatriptan to Rizatriptan benzoate. | 03-05-2009 |
| 20100234617 | PROCESS FOR PREPARATION OF LETROZOLE AND ITS INTERMEDIATES - The present invention relates to an improved process for preparation of the non-steroidal aromatase inhibitor drug, Letrozole of formula (I) and its intermediates, 4-[1-(1,2,4-triazolyl)methyl]-benzonitrile of formula (IV) and 4-[1-(1,2,4-triazolyl)methyl]-benzonitrile hydrochloride of formula (VII), all having a purity of ≧99%, which is simple, convenient, economical, does not use hazardous chemicals and industrially viable. | 09-16-2010 |
| 20090286989 | Process for High Purity Anastrozole - The present invention relates to an improved process for the preparation of anastrozole having enhanced purity from crude anastrozole having isomeric impurity content up to less than | 11-19-2009 |
| 20090247765 | PROCESS FOR PREPARING PURE ANASTROZOLE - The present invention discloses two new related substances (6) and (7) of Anastrozole synthesis from Q. A. Salt (5) as in Scheme—1 and purification procedures to get Anastrozole (1) free from (6) and (7). | 10-01-2009 |
| 20110184188 | Insecticidal Benzenedicarboxamide Derivative - The present invention relates to a novel benzenedicarboxamide derivative and the use thereof as an insecticide having the formula (I) wherein the chemical groups W | 07-28-2011 |
| 548263200 | Chalcogen bonded directly to ring carbon of the triazole ring | 13 |
| 20110201822 | METHODS FOR PRODUCTION OF 1,2,4-TRIAZOL-3-ONE - Novel methods for producing 1,2,4-triazol-3-one from semicarbazide hydrochloride and formic acid are provided. In methods of this invention, water is used in removal of unreacted formic acid to increase yield and purity of produced 1,2,4-triazol-3-one. | 08-18-2011 |
| 20130072689 | Regioselective chlorination of the phenyl ring of 4,5-dihydro-1-phenyl-1H-1,2,4-triazol-5-ones - An improved process for selectively chlorinating 4,5-dihydro-1-phenyl-1H-1,2,4-triazole-5-ones, including 4,5-dihydro-3-alkyl-1-phenyl-1H-1,2,4-triazole-5-ones and 4-haloalkyl-4,5-dihydro-3-alkyl-1-phenyl-1H-1,2,4-triazole-5-ones in the 4-position of the phenyl ring by dissolving the compounds in a synergistic ratio of polar aprotic solvents, preferably acetonitrile and N,N-dimethylformamide in a 7:3 ratio and reacting the solution with chlorine gas. | 03-21-2013 |
| 20110263867 | METHODS FOR PRODUCTION OF 1,2,4-TRIAZOL-3-ONE - Novel methods for producing 1,2,4-triazol-3-one from semicarbazide hydrochloride and formic acid are provided. In methods of this invention, ethanol is used in removal of unreacted formic acid to increase yield and purity of produced 1,2,4-triazol-3-one. | 10-27-2011 |
| 20120232285 | Sulfonyl-1,2,4-triazole salts - The invention relates to triazole salts, to their preparation and to applications thereof. The salts have at least one anionic triazolium group which carries at least one chlorosulphonyl, fluorosulphonyl or alkoxyfluorosulphonyl group, each of the anionic groups being combined with a proton or a cation that has a valency of less than or equal to 4. The salts are useful as synthesis reagents, as chemical-reaction or polymerization catalysts, and as ion-conducting materials for electrochemical generators, supercapacitors and electrochromic devices. | 09-13-2012 |
| 20120289706 | Method for Producing Triazolinthione Derivatives and Intermediates Thereof - The present invention relates to a new process for the preparation of substituted thiotriazolo groups of the general formula (I) | 11-15-2012 |
| 548263400 | Plural chalcogen bonded directly to ring carbons of the triazole ring | 2 |
| 20100056798 | Substituted thien-3-yl-sulphonylamino(thio)carbonyl-triazolin(ethi)ones - The invention relates to processes for the preparation of compounds of general formula (I) and salts thereof: | 03-04-2010 |
| 548263600 | The 1- and 2- positions of the triazole ring are unsubstituted, or are alkyl or cycloalkyl substituted only | 1 |
| 20110009640 | BIFUNCTIONAL PHENYL ISO (THIO) CYANATES, PROCESSES AND INTERMEDIATES FOR THEIR PREPARATION - A process for preparing phenyl iso(thio)cyanates of the formula I in which a compound of the formula II or its HCl adduct is reacted with a phosgenating agent | 01-13-2011 |
| 548263800 | Halogen or nitrogen attached directly to the triazole ring by nonionic bonding | 3 |
| 20100081827 | 2-(5-BROMO-4-(4-CYCLOPROPYLNAPHTHALEN-1-YL)-4H-1,2,4-TRIAZOL-3-YLTHIO)ACET- IC ACID AND METHYL ESTER | 04-01-2010 |
| 20100069645 | 2-(5-BROMO-4-(4-CYCLOPROPYLNAPHTHALEN-1-YL)-4H-1,2,4-TRIAZOL-3-YLTHIO)ACET- IC ACID AND METHYL ESTER - A series of S-triazolyl α-mercaptoacetanilides having general structure (I) are provided, where Q is CO | 03-18-2010 |
| 20090076282 | 3-TRIAZOLYLPHENYL SULFIDE DERIVATIVE AND INSECTICIDE/ACARICIDE/NEMATICIDE CONTAINING THE SAME AS ACTIVE INGREDIENT - To provide novel 3-triazolylphenyl sulfide derivatives having excellent soil treatment activity as insecticides, miticides or nematicides for agricultural and horticultural plants. | 03-19-2009 |
| 548264200 | Carbon bonded directly to the chalcogen | 3 |
| 20090012304 | Process for preparing triazolones - The present process provides a improved method for the preparation of alkylsulfanyl substituted triazoles 2 which are useful intermediates in a new process for the preparation of triazolones 20. | 01-08-2009 |
| 20100280256 | PROCESS FOR PREPARING TRIAZOLONES - The present process provides a improved method for the preparation of alkylsulfanyl substituted triazoles 2 which are useful intermediates in a new process for the preparation of triazolones 20. | 11-04-2010 |
| 548264400 | Nitrogen or additional chalcogen attached indirectly to the chalcogen by acyclic nonionic bonding | 1 |
| 20080319201 | N[S(4-ARYL-TRIAZOL-3-YL)alpha-MERCAPTOACETYL] -P-AMINO BENZOIC ACIDS AS HIV REVERSE TRANSCRIPTASE INHIBITORS - A series of S-triazolyl α-mercaptoacetanilides having N-(α-mercaptoacetyl) p amino benzoic acid derivatives. | 12-25-2008 |
| 548264800 | Nitrogen attached directly to the triazole ring by nonionic bonding | 2 |
| 20110190507 | THIOPHENE-CARBOXAMIDES USEFUL AS INHIBITORS OF PROTEIN KINASES - The present invention relates to compounds useful as inhibitors of protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising said compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, or disorders. The invention also relates to processes for preparing compounds of the inventions. | 08-04-2011 |
| 548265600 | The nitrogen is further bonded to hydrogen only | 1 |
| 20130023666 | ARYL (1H-1,2,4-TRIAZOL-1-YL) COMPOUND, AND PROCESS FOR PRODUCTION THEREOF - A process for production of a (1H-1,2,4-triazol-1-yl)benzene compound represented the general formula (5) | 01-24-2013 |
| 548265800 | Benzene ring bonded directly to ring nitrogen of the triazole ring, and directly to the acyclic carbon of a benzoyl or benzyl group | 3 |
| 20120203007 | POLYMORPHIC FORMS OF DEFERASIROX (ICL670A) - The invention relates to crystalline forms of 4-[3,5-bis(2-hydroxyphenyl)-[1,2,4]triazol-1-yl]benzoic acid and to its amorphous form, to processes for the preparation thereof, to compositions containing the same and their uses for the manufacture of a medicament for the treatment of the human body. | 08-09-2012 |
| 20110034702 | METHOD FOR PREPARING 4-[3,5-BIS(2-HYDROXYPHENYL)-[1,2,4]TRIAZOL-1-YL]-BENZOIC ACID - A method for preparing 4-[3,5-bis(2-hydroxyphenyl)-[1,2,4]triazol-1-yl]benzoic acid of formula (I) by reaction of 2-(2-hydroxyphenyl)benz[e][1,3]oxazin-4-one of formula (II) with 4-hydrazinobenzoic acid of formula (III) in an organic acid or in a mixture of an organic acid and an organic solvent. | 02-10-2011 |
| 20120029202 | Process for the Preparation of 5-Substituted 3-Aryl-3-(trifluoromethyl)-3,4-dihydro-2H-pyrroles - The present invention relates to a process for the manufacturing of 5-substituted 3-aryl-3-(trifluoromethyl)-3,4-dihydro-2H-pyrroles of formula (I) | 02-02-2012 |
| 548266200 | Additional unsaturated hetero ring attached directly or indirectly to the triazole ring by nonionic bonding | 2 |
| 20110015404 | Electroluminescent Materials - Compounds of the general structure: Z-A-(S—B) | 01-20-2011 |
| 548266600 | The additional unsaturated hetero ring and the triazole ring are attached to the same acyclic atom or to the same acyclic chain | 1 |
| 20110295019 | Method for Producing Hydroxymethyl Diphenyloxiranes and Corresponding 1-azolylmethyl-1,2-diphenyloxiranes - The present invention relates to a method for producing 1-hydroxymethyl-1,2-diphenyloxiranes from 2,3-diphenylpropenals by means of epoxidation and reduction. The formation of objectionable by-products can be suppressed in that the reduction is started before the 2,3-5 diphenylpropenal is completely converted. The hydroxymethyl diphenyloxiranes represent valuable intermediate products for producing 1-azolylmethyl-1,2-diphenyloxiranes, wherein the latter can be easily produced from said intermediate products by introducing the azolyl group. | 12-01-2011 |
| 548266800 | Cyano or -C(=X)-, wherein X is chalcogen, bonded directly to the triazole ring | 1 |
| 20120116095 | GLYCINE TRANSPORTER INHIBITORS - The present invention aims to provide novel compounds represented by formula [I] or pharmaceutically acceptable salts thereof: | 05-10-2012 |
| 548267200 | Nitrogen attached indirectly to the triazole ring by acyclic nonionic bonding | 6 |
| 548267400 | The nitrogen is double or triple bonded to carbon | 6 |
| 20110124877 | 5-BENZYL-4-AZOLYLMETHYL-4-SPIRO[2.4]HEPTANOL DERIVATIVES, METHODS FOR PRODUCING THE SAME, AND AGRO-HORTICULTURAL AGENTS AND INDUSTRIAL MATERIAL PROTECTING AGENTS THEREOF - To provide a novel 5-benzyl-4-azolylmethyl-4-spiro[2.4]heptanol derivative, a method for producing the same, and an agro-horticultural agent and an industrial material protecting agent containing as an active ingredient the abovementioned 5-benzyl-4-azolylmethyl-4-spiro[2.4]heptanol derivative. | 05-26-2011 |
| 20100099888 | Process for the preparation of anticancer drugs - A process for preparing Anastrozole is provided. In the process the steps of
| 04-22-2010 |
| 20100099887 | Process for the Preparation of Pure Anastrozole - A process for the preparation of anastrozole which comprises: a) brominating 3,5-bis(2-cyanoprop-2-yl)toluene (II) in an organic solvent using a brominating agent to obtain 3,5-bis(2-cyanoprop-2-yl)benzylbromide (III); b) heating the reaction mass of step a) to the reflux temperature of the organic solvent for a period of time no longer than 3 hours; c) isolating and purifying the bromo intermediate (III) using an organic solvent; d) alkylating the bromo intermediate in the presence of a base, optionally a phase transfer catalyst, a 1,2,4-triazole and an organic solvent to obtain anastrozole; and e) isolating and purifying the anastrozole from an organic solvent. | 04-22-2010 |
| 20080207915 | Process for the Preparation of 2,2'-[5-(1H-1,2,4-Triazole-1-Ylmethyl) -1,3-Phenylene] Di (2-Methylpropionitrile) - The present invention discloses a process for the preparation of Anastrozole of the formula I in high purity and in high yield. 3,5-bis(halomethyl)toluene is prepared by reacting mesitylene with N-halosuccinimide in the presence of light or dibenzoyl peroxide or azobis isobutyronitrile as a catalyst and in a chlorinated solvent. 3,5-bis(halomethyl)toluene is cyanated with metal cyanide in the presence of a catalyst and in water, organic solvent or mixture thereof at temperature of 40 to 60° C. to obtain 2,2′-(5-methyl-1,3 phenylene)diacetonitrile which is further methylated with iodomethane in the presence of base and an organic solvent at temperature of 0 to 15° C. to obtain 2,2′-(5-methyl-1,3-phenylene)di(2-methyl-propiononitrile). The product obtained is treated with N-halosuccinimide in the presence of a catalyst and in a chlorinated solvent at temperature of 60 to 100° C. to obtain 2,2′-(5-halomethyl-1,3-phenylene)di(2-methyl propionitrile) which was further treated with potassium or sodium salt 1,2,4-triazole at temperature of 20 to 50° C. in dimethyl formamide to obtain crude 2,2′-[5-( | 08-28-2008 |
| 20110065927 | PROCESS FOR PREPARING PURE ANASTROZOLE - The present invention discloses two new related substances (6) and (7) of Anastrozole synthesis from Q.A. Salt (5) as in Scheme-1 and purification procedures to get Anastrozole (1) free from (6) and (7). | 03-17-2011 |
| 20120232286 | AZOLE DERIVATIVES, METHODS FOR PRODUCING THE SAME, INTERMEDIATE THEREOF, AGRO-HORTICULTURAL AGENTS - An azole derivative according to the invention is represented by Formula (I), wherein each of R | 09-13-2012 |
| 548267800 | Chalcogen attached indirectly to the triaole ring by acyclic nonionic bonding | 2 |
| 20090312558 | PROCESS FOR THE PREPARATION OF ARYLCYCLOPROPOANE CARBOXYLIC CARBONITRILES, AND COMPOUNDS DERIVED THEREFROM - The present invention relates to an efficient process for preparing an arylcyclopropanecarbonitrile, which involves the use of sulfolane as a solvent. | 12-17-2009 |
| 548268200 | The triazole ring and the chalcogen are bonded directly to the same acyclic carbon | 1 |
| 20120238762 | AZOLE DERIVATIVES AND METHODS FOR PRODUCING THE SAME, INTERMEDIATE COMPOUNDS FOR THE DERIVATIVES AND METHODS FOR PRODUCING THE SAME, AND AGRO-HORTICULTURAL AGENTS AND INDUSTRIAL MATERIAL PROTECTING AGENTS CONTAINING THE DERIVATIVES - To provide an azole derivative which is contained as an active ingredient in an agro-horticultural agent having an excellent controlling effect on diseases. An azole derivative according to the invention is represented by Formula (I), wherein R | 09-20-2012 |
| 548269200 | Processes for forming the triazole ring | 3 |
| 20090118517 | Purification process for anastrozole intermediate - The invention is directed to processes for purifying the Anastrozole intermediate, 3,5-bis(2-cyanoisopropyl)toluene, processes for producing Anastrozole, processes for preparing Anastrozole pharmaceutical compositions, and Anastrozole and Anastrozole pharmaceutical compositions prepared with the processes of the invention. | 05-07-2009 |
| 20090221837 | Process for the Preparation of Pure Anastrozole - The present invention relates to the improved process for the preparation of Anastrozole free from the impurities arising due to impure 3,5-bis-(1-cyano-1-methylethyl)benzylbromide (2) and other related impurities resulting from incomplete/over-reaction of 2,2-(5-methyl-1,3-phenylene)-bis(2-methylpropionitrile (I). | 09-03-2009 |
| 20110077410 | Process for the Preparation of 1-Phenyl-1,2,4-triazoles - The present invention relates to a process for the preparation of 1-phenyl-1,2,4-triazoles by converting phenyl hydrazides to N′-(iminomethyl)-N′-phenylacetyl hydrazides and the further reaction thereof by cyclization to give 1-phenyl-1,2,4-triazoles. | 03-31-2011 |
| 548269400 | Benzene ring bonded directly to the triazole ring | 2 |
| 20110015405 | Process for preparing chiral 3-triazolyl sulphoxide derivatives - The present invention relates to a catalytic process for preparing 3-triazolyl sulphoxide derivatives in enantiomerically pure or enantiomerically enriched form. | 01-20-2011 |
| 20100190997 | Process for the Preparation of Letrozole - The present invention relates to the process for the preparation of Letrozole free from its regioisomer (7) and other impurities by selective extraction of desired intermediate (3) using suitable solvent and mixture of solvents. | 07-29-2010 |
