Class / Patent application number | Description | Number of patent applications / Date published |
546236000 | Chalcogen attached indirectly to the piperidine ring by nonionic bonding | 28 |
20090326233 | 4-PHENYLPIPERIDINE COMPOUNDS - The invention relates to a compound, and pharmaceutically acceptable salts, having the formula I: | 12-31-2009 |
20100125141 | PROCESS FOR PREPARING 4-[2-(2-FLUOROPHENOXYMETHYL)PHENYL]PIPERIDINE COMPOUNDS - The invention relates to processes and intermediates for preparing compounds of formula I: | 05-20-2010 |
546237000 | The chalcogen, X, is in a -C(=X)- group | 23 |
20080227983 | PIPERIDINE DERIVATIVES AND PROCESS FOR THEIR PRODUCTION - The present invention relates to substantially pure piperidine derivative compounds of the formulae: | 09-18-2008 |
20080293948 | PROCESS FOR THE PREPARATION OF KETO COMPOUNDS - A process for the preparation of 4-[1-oxo-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-α,α-dimethylbenzeneacetic acid, useful as an intermediate for the preparation of fexofenadine, is provided. | 11-27-2008 |
20160052881 | NOVEL CHALCONE DERIVATIVES HAVING AN ANTI-ALLERGIC ACTIVITY - The present invention relates to the compounds of formula (I): | 02-25-2016 |
546238000 | The -C(=X)- is part of a -C(=X)X- group, wherein the X's are the same or diverse chalcogens | 20 |
20090111993 | Process for Preparing Beta-(Fluorophenyl)-Propanoate Ester Derivatives - A process for preparing a compound of formula (I) comprising reacting a compound of formula (II) with a fluorinated boron species of formula (III) in the presence of: an alcohol; a rhodium (I) pre-catalyst species; a suitable ligand that binds to the rhodium (I) pre-catalyst species to form a catalyst complex; a base; and, a suitable solvent; the process being carried out at a temperature in the range 40 to 110° C. The compounds of formula (I) are useful in the preparation of pharmaceutically active compounds. | 04-30-2009 |
20100179327 | Synthesis of Methylphenidate and Analogs Thereof - A synthetic process for the preparation of amino acid esters such as methylphenidate and analogs thereof is disclosed. The process involves reacting an amino acid such as α-phenyl-α-(2-piperidinyl)acetic acid or an analog thereof with an alcohol such as methanol in the presence of an acid and a water sequestrant such as trimethyl orthoacetate. In some embodiments, the water sequestrant is added to the reaction mixture after an initial period of esterification and then the reaction is allowed to continue. The α-phenyl-α-(2-piperidinyl)acetic acid methyl ester or analog thereof is then isolated from the reaction mixture. In one variation of the process, the supernatant liquid may be recycled in subsequent runs to increase yield and product purity. | 07-15-2010 |
20100249422 | ACYLATION REACTION OF HYDROXYL GROUP - Disclosed is a selective ester production process of an alcoholic hydroxyl group, which proceeds under chemically mild conditions, while having adequate environmental suitability, operability and economical efficiency. Specifically disclosed is a process for producing an ester compound, which is characterized in that an alcohol and a carboxylic acid ester compound are reacted in the presence of a compound containing zinc element, thereby selectively acylating a hydroxyl group of the alcohol. | 09-30-2010 |
20110130569 | Process for the Preparation of d-threo-Ritalinic Acid Hydrochloride by Resolution of dl-threo-Ritalinic Acid Using Chiral Carboxylic Acid - The invention disclosed in this application relates to an improved process for the manufacture of d-threo-ritalinic acid hydrochloride and l-threo-ritalinic acid hydrochloride in an optically pure form by the resolution of dl-threo-ritalinic acid using a chiral carboxylic acid The d-threo-ritalinic acid hydrochloride prepared by the process of the present invention on esterification gives d-threo-methylphenidate, a very well known CNS stimulant. | 06-02-2011 |
20130190502 | ACYLATION REACTION OF HYDROXYL GROUP - Disclosed is a selective ester production process of an alcoholic hydroxyl group, which proceeds under chemically mild conditions, while having adequate environmental suitability, operability and economical efficiency. Specifically disclosed is a process for producing an ester compound, which is characterized in that an alcohol and a carboxylic acid ester compound are reacted in the presence of a compound containing zinc element, thereby selectively acylating a hydroxyl group of the alcohol. | 07-25-2013 |
20150038720 | Low-Temperature Synthesis of Methylphenidate Hydrochloride - The present invention describes a process for the preparation of methylphenidate hydrochloride. The process involves the esterification of ritalinic acid and methanol in the presence of an acid catalyst at a low temperature. The process may optionally involve the addition of an orthoester. | 02-05-2015 |
20150051400 | A PROCESS FOR THE PREPARATION OF METHYLPHENIDATE HYDROCHLORIDE AND ITS INTERMEDIATES THEREOF - The present invention relates to an industrially feasible and economically viable process for the preparation of methylphenidate hydrochloride of formula I and its intermediates thereof. | 02-19-2015 |
20150133667 | PROCESS FOR THE PREPARATION OF METHYLPHENIDATE AND PHARMACEUTICAL SALTS THEREOF - The present invention is directed to an improved process for the preparation of methylphenidate, stereoisomer, mixture of stereoisomers and pharmaceutically acceptable salts thereof, more particularly, the sulfate and hydrochloride salts of methylphenidate, di-threo-methylphenidate and dex-methylphenidate. Methods of removing or reducing the amount of impurities from the above described process are also disclosed. | 05-14-2015 |
20160090356 | METHODS FOR PREPARING D-THREO-METHYLPHENIDATE USING DIAZOMETHANE, AND COMPOSITIONS THEREOF - Novel methods and systems for producing a substantially pure d-threo stereoisomer of methylphenidate or a salt thereof are provided. In particular, methods and systems for producing d-threo-methylphenidate hydrochloride in pure stereoisomeric form from d-threo-ritalinic acid hydrochloride using diazomethane are described. The described methods can be performed on a large scale, and thus provide d-threo methylphenidate or a salt thereof, and particularly the hydrochloride salt of d-threo-methylphenidate, in stereoisomerically pure form and in large quantities from a single batch reaction. Also described are novel compositions of d-threo methylphenidate hydrochloride. | 03-31-2016 |
546239000 | Plural carbocyclic rings containing | 11 |
20090012301 | FEXOFENADINE CRYSTAL FORM AND PROCESSES FOR ITS PREPARATION THEREOF - Provided is a crystalline form of fexofenadine free base and processes for its preparation. | 01-08-2009 |
20090124810 | PROCESS FOR PRODUCTION OF PIPERIDINE DERIVATIVES - Processes are disclosed for preparing piperidine derivative compounds of the formulae I, II or III: | 05-14-2009 |
20090306392 | GSM INTERMEDIATES - The present invention relates the use of compounds having the general Formula I, wherein the definitions or R | 12-10-2009 |
20100010227 | PROCESS FOR PRODUCTION OF PIPERIDINE DERIVATIVES - The present invention discloses a process for preparing the piperidine derivative compound 4-[4-[4-hydroxydiphenylmethyl)-1-piperidinyl]-1-hydroxybutyl]-α,α-dimethylphenylacetic acid of formula | 01-14-2010 |
20100016599 | Process for Preparing Fexofenadine - A process for preparing fexofenadine is described that includes the purification of 4-[4-chloro-1-oxobutyl]-2,2-dimethylphenyl acetic acid alkyl ester by means of suspension in a hydrocarbon, preferably n-heptane. The compound thus obtained is dissolved in a suitable solvent and condensed with azacyclanol to give the compound shown below | 01-21-2010 |
20100137605 | PROCESS FOR PRODUCTION OF PIPERIDINE DERIVATIVES - The present invention is directed to a process for preparing the piperidine derivative compound 4-[4-[4-hydroxydiphenylmethyl)-1-piperidinyl]-1-hydroxybutyl]-α,α-dimethylphenylacetic acid of formula | 06-03-2010 |
20100174085 | CRYSTALLINE POLYMORPHIC FORMS OF FEXOFENADINE - The present invention is related to a novel polymorph of Fexofenadine and processes of preparation thereof. | 07-08-2010 |
20100228034 | PROCESS FOR THE PREPARATION OF KETO INTERMEDIATES - Process for the preparation of 4-[1-oxo-4-[4-(hydroxyphenylmethyl)-1-piperidinyl]butyl]-α,α-dimethylbenzenacetic acid, which is an intermediate useful in the preparation of fexofenadine, by hydrating asymmetric alkynes. | 09-09-2010 |
20110190504 | Process for preparing fexofenadine - A process for preparing fexofenadine is described, which provides for the hydrolysis of 4-[4-[4-(hydroxydiphenylmethyl)-1-piperidyl]-1-oxobutyl]-α,α-dimethylbenzeneacetic acid-alkyl ester, in a mixture of water and optionally an organic solvent, in the presence of a base; the carboxylate salt of 4-[4-[4-(hydroxydiphenylmethyl)-1-piperidyl]-1-oxobutyl]-α,α-dimethylbenzeneacetic acid is thus obtained, which is then directly reduced as carboxylate in a basic environment with hydrogen in the presence of a suitable hydrogenation catalyst to give the carboxylate of fexofenadine, which is precipitated by neutralisation of the solution. | 08-04-2011 |
20120309973 | PREPARATION OF 2-(4-BROMOPHENYL)-2-METHYLPROPANOIC ACID - Selective bromination of 2-methyl-2-phenylpropanoic acid in aqueous medium is described to obtain pure 2-(4-bromophenyl)-2-methylpropanoic acid, which is a useful key intermediate in the process of manufacturing pure fexofenadine. | 12-06-2012 |
20130237709 | INTERMEDIATES USEFUL FOR THE SYNTHESIS OF FEXOFENADINE, PROCESSES FOR THEIR PREPARATION AND FOR THE PREPARATION OF FEXOFENADINE - Intermediates useful for the synthesis of fexofenadine, processes for their preparation and processes for the synthesis of fexofenadine are described. | 09-12-2013 |
546240000 | The chalcogen is in an -OH or -OM group (M is Group IA or Group IIA light metal) | 3 |
20120259122 | BENZYLPIPERIZINE COMPOUND - Disclosed is a benzylpiperizine compound represented by formula (1) or a pharmaceutically acceptable salt thereof, which is useful as a medicinal agent such as an antidepressant agent. (In the formula (1), R | 10-11-2012 |
20160136629 | SPIRO-1,1'-BINDANE-7,7-BISPHOSPHINE OXIDES AS HIGHLY ACTIVE SUPPORTING LIGANDS FOR PALADIUM-CATALYZED ASYMMETRIC HECK REACTION - The present invention relates to catalyst complexes comprising palladium (Pd) and at least one spiro-1,1′-biindane-7,7′-bisphosphine oxide ligand as disclosed herein, and their use. The present invention is further directed to the asymmetric catalyzed covalent carbon-carbon single bond formation from aryl, heteroaryl and alkenyl triflates and halides and olefins utilising the said catalyst complexes. | 05-19-2016 |
546241000 | The -OH or -OM is bonded to an acyclic carbon, which carbon is bonded directly to two rings | 1 |
20090221830 | Fexofenadine Polymorphs and Processes of Preparing the Same - Anhydrous crystalline fexofenadine hydrochloride Form C, crystalline fexofenadine acetate monohydrate Form D, crystalline fexofenadine acetate dihydrate Form E and crystalline fexofenadine free base monohydrate Form F, processes of preparing the same, pharmaceutical compositions thereof, therapeutic uses thereof and methods of treatment therewith. | 09-03-2009 |