Class / Patent application number | Description | Number of patent applications / Date published |
546047000 | Plural ring hetero atoms in the pentacyclo ring system | 22 |
546048000 | Three or more ring hetero atoms in the pentacyclo ring system | 17 |
20080269493 | Crystalline forms of topotecan hydrochloride and processes for making the same - Novel crystalline forms of topotecan hydrochloride and processes of making the same are disclosed. | 10-30-2008 |
20090023927 | Process for producing tricyclic ketone - In order to efficiently supply CPT, which is a starting compound of irinotecan hydrochloride and a variety of camptothecin derivatives, by a practical total synthesis, the invention provides a means of efficiently preparing a tricyclic ketone that corresponds to a CDE ring moiety of a camptothecin (CPT) skeleton. | 01-22-2009 |
20090048446 | Process For Producing Benzo[C]Phenanthridine Derivative - A compound represented by the following formula (1): [wherein R1 and R2 each independently represents hydroxy, provided that R1 and R2 may be bonded to each other to form methylenedioxy, etc.; X represents halogeno; and R3 represents a protective is subjected to a cyclization reaction with the aid of an organic silyl hydride and then aromatized with an oxidizing agent to produce a benzo [c] phenanthridine derivative represented by the following formula (2): [wherein R1, R2, and R3 have the same meanings as defined above]. | 02-19-2009 |
20090143588 | QUARTZ GLASS MICRO-PHOTOREACTOR AND SYNTHESIS OF 10-HYDROXYCAMPTOTHECIN AND 7-ALKYL 10-HYDROXYCAMPTOTHECIN - A process for the production of 10-hydroxycamptothecin | 06-04-2009 |
20090221826 | Process for making topotecan - A process of making topotecan or a pharmaceutically acceptable salt thereof comprising reacting an iminium salt with 10-hydroxy-camptothecin. | 09-03-2009 |
20090306387 | METHOD OF MANUFACTURING OF 7-ETHYL-10-HYDROXYCAMPTOTHECIN - The method of manufacturing of 7-ethyl-10-hydroxycamptothecin of formula I characterized in that 7-ethyl-1,2,6,7-tetrahydrocampotothecin of formula IV is oxidized with an oxidizing agent selected from the group comprising iodosobenzene, an ester of iodosobenzene, sodium periodate, potassium periodate, potassium peroxodisulfate and ammonium peroxodisulfate, in a solvent formed by a saturated aliphatic monocarboxylic add containing 1 to 3 carbon atoms, and in the presence of water. | 12-10-2009 |
20100168426 | NOVEL PROCESSES FOR THE PRODUCTION OF USEFUL INTERMEDIATES - The present application relates to a new process for the asymmetric production of 3-(pyridin-4-yl)-3-hydroxy-pentanoic acid derivatives, which are useful intermediates in the manufacture of compounds that are known to show antiproliferative activity. | 07-01-2010 |
20100249414 | CRYSTALLINE FORM II OF 7-(DIMETHOXY-METHYL) CAMPTOTHECIN, ITS USE AS INTERMEDIATE AND PRODUCTS OBTAINED THEREFROM - This invention relates to a process for preparing a crystalline form of (4S)-11-(dimethoxymethyl)-4-ethyl-4-hydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]qui-noline-3,14(4H,12H)-dione (also named 7-(dimethoxy-methyl)camptothecin). With the provision of a particular crystallization step, in appropriate way, a new crystalline form of the above compound is obtained. The process for the preparation of the polymorph Form II comprises transforming camptothecin to the corresponding 7-(dimethoxy-methyl)-camptothecin, and crystallizing it from methanol. | 09-30-2010 |
20100292476 | Berberrubine Derivatives Having Antifungal Activities - The present invention relates to a berberrubine derivative having superior antifungal activity, more particularly to a berberrubine derivative having inhibitory activity against chitin synthase, which participates in the synthesis of chitin and is essential in the growth of fungi, and having a potent antifungal activity against human pathogenic fungi. | 11-18-2010 |
20110112298 | METHOD FOR PRODUCING CAMPTOTHECIN DERIVATIVES - The invention offers a method of hydrogenating camptothecin in inert solvent in the presence of nickel catalyst, whereby selective hydrogenation of camptothecin can be very efficiently accomplished using the low-cost catalyst. | 05-12-2011 |
20110144342 | PROCESS FOR THE PREPARATION OF 7-ETHYL-10-[4- (1-PIPERIDINO)- 1-PIPERIDINO] CARBONYLOXY-CAMPTOTHECIN HYDROCHLORIDE TRIHYDRATE - The present invention relates to process for the preparation of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothecin hydrochloride trihydrate and process for the isolation of 1-chlorocarbonyl-4-piperidinopiperidine and novel crystalline form of 1-chlorocarbonyl-4-piperidinopiperidine and 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothecin. | 06-16-2011 |
20120041204 | PROCESS FOR PRODUCING TRICYCLIC KETONE - In order to efficiently supply CPT, which is a starting compound of irinotecan hydrochloride and a variety of camptothecin derivatives, by a practical total synthesis, the invention provides a means of efficiently preparing a tricyclic ketone that corresponds to a CDE ring moiety of a camptothecin (CPT) skeleton. | 02-16-2012 |
20120142926 | Process for Production of Camptothecin Derivative - Disclosed is a process for production of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin from a camptothecin composition containing 18,19-dehydrocamptothecin without producing any vinyl form of the compound. The process is characterized by catalytically reducing at least one compound selected from a compound (1) and others in the process of producing a compound (5) from a composition containing the compound (1). | 06-07-2012 |
20120316341 | FLUORINATION OF ORGANIC COMPOUNDS - Methods for fluorinating organic compounds are described herein. | 12-13-2012 |
20130184462 | METHOD FOR PREDICTING AND MODELING ANTI-PSYCHOTIC ACTIVITY USING VIRTUAL SCREENING MODEL - The present invention relates to the development of a virtual screening model for predicting antipsychotic activity using quantitative structure activity relationship (QSAR), molecular docking, oral bioavailability, ADME and Toxicity studies. The present invention also relates to the development of QSAR model using forward stepwise method of multiple linear regression with leave-one-out validation approach. QSAR model showed activity-descriptors relationship correlating measure (r | 07-18-2013 |
20160144045 | MULTI-ARM POLYMERIC ALKANOATE CONJUGATES - Among other aspects, provided herein are multi-armed polymer conjugates comprising an alkanoate-linker, compositions comprising such conjugates, and related methods of making and administering the same. Methods of treatment employing such conjugates and related uses are also provided. The conjugates are prepared with high drug loading efficiencies. | 05-26-2016 |
20180021444 | MULTI-ARM POLYMER PRODRUGS | 01-25-2018 |
546049000 | Two ring nitrogens in the pentacyclo ring system (e.g., quinacridones, etc.) | 5 |
20130053568 | 2,5-DI(METHOXYANILINO) TEREPHTHALIC ACID POLYMORPHS AND QUINACRIDONES REALIZED THEREFROM2,5-DI(METHOXYANILINO) TEREPHTHALIC ACID POLYMORPHS AND QUINACRIDONES REALIZED THEREFROM - 2,5-di(p-methoxyanilino)terephthalic acid crystal types I and II are made by controlling the pH during the recovery of the oxidized product of the condensation of dimethylsuccinyl succinate with p-methoxyaniline. The resulting 2,5-di(p-methoxyanilino)-terephthalic acid can be converted into 2,9-dimethoxyquinacridone or a solid solution thereof having controlled characteristics. | 02-28-2013 |
20150299196 | Flindersia Alkaloids, Derivatives and Analogs: Compositions and Methods for Producing the Same - The present invention provides methods for chemically synthesizing analogs and derivatives of naturally-occurring | 10-22-2015 |
546050000 | Ring nitrogen is shared by two of the cyclos (e.g., yohimbanes, etc.) | 2 |
546051000 | Ring nitrogen is shared by five-membered cyclo and six-membered cyclo (e.g., vincamine, etc.) | 1 |
546052000 | Additional ring nitrogen in the five-membered cyclo | 1 |
20120165530 | NAPHTHALENE MONOIMIDE DERIVATIVES AND USE THEREOF AS PHOTOSENSITIZERS IN SOLAR CELLS AND PHOTODETECTORS - The present invention relates to compounds of the formulae Ia and Ib | 06-28-2012 |
546053000 | Having -C(=X)-, wherein X is chalcogen, bonded directly to ring carbon of the pentacyclo ring system and also bonded directly to chalcogen or nitrogen | 1 |
546054000 | Plural chalcogens bonded directly to the same cyclo as is the -(C=X)- group | 1 |
20120065401 | METHODS TO INHIBIT OR AUGMENT AN INFLAMMATORY RESPONSE - Isolated and purified chemokine peptides, variants, and derivatives thereof, as well as chemokine peptide analogs, are provided. | 03-15-2012 |
546056000 | Three or more ring carbons of the pentacyclo ring system are substituted (e.g., substituted quinacridones, etc.) | 1 |
20090299070 | Organic Semiconductors and Their Manufacture - The invention relates to a semiconductor device comprising a compound of the formula I and of the formula XXI, wherein the symbols have the meanings defined in the specification, to the novel compounds of the formula I and XXI and to the use of such a compound as an organic semiconductor for the preparation of an electronic device, and further compounds and devices, as well as other embodiments given in the specification. | 12-03-2009 |