Class / Patent application number | Description | Number of patent applications / Date published |
546038000 | Hexacyclo ring system having the six-membered hetero ring as one of the cyclos | 37 |
20110251393 | HELICENE DERIVATIVE, AXIALLY ASYMMETRIC AMINO ACID, AMINE OR AMINOALCOHOL DERIVATIVE, PERYLENE DERIVATIVE OR SALT THEREOF, AND METHODS FOR PRODUCING SAME - The invention provides a helicene derivative, axially chiral amino acid, amine or amino alcohol derivative, and azaperylene, such as compounds represented by Formulae (I), (I′), (II), (II′), and (III): | 10-13-2011 |
20130085280 | MATERIALS AND METHODS FOR THE PREPARATION OF ANISOTROPICALLY-ORDERED SOLIDS - The invention provides materials and methods for making anisotropic solids which may be in the form of films, layers, shaped elements, and other shaped articles. The methods provide anisotropic solids without the need for rolling, rubbing, or stretching to impart orientational alignment of the molecules of the solid. The methods employ organic or organometallic compounds which are soluble orienting molecules. The solvent or solvent system must be sufficiently volatile to be removed without disruption of the molecular orientation. The soluble orienting molecules include those containing one or more hydrophilic and/or ionic groups and the solvent or solvent system can be a polar organic solvent or solvent system or an aqueous solvent or solvent system. The invention also provides novel compounds having quaterrylene, perylene and naphthalene ring systems carrying one or more hydrophilic and/or ionic groups. These novel compounds can exhibit useful absorption and fluorescence properties in solution and in the solid phase and can exhibit useful liquid crystalline properties. | 04-04-2013 |
20140018539 | BENZOFLUORANTHENE DERIVATIVE AND ORGANIC ELECTROLUMINESCENCE ELEMENT COMPRISING SAME - A benzofluoranthene derivative represented by the following formula (1): | 01-16-2014 |
546039000 | Two of the cyclos share at least three ring members (e.g., etheno morphides, etc.) | 30 |
20080312441 | Use of Oripavine as a Starting Material For Buprenorphine - There is provided a method for the synthesis of norbuprenorphine, and ultimately buprenorphine, utilizing oripavine as the starting material. Conventional methods of producing buprenorphine utilize thebaine as the starting material, requiring an O-demethylation step, typically a low to moderate yield transformation. The present use of oripavine as a starting material does not require an O-demethylation step, since the oripavine molecule lacks an O-3 methyl group. | 12-18-2008 |
20100081813 | Processes for the synthesis of opiates alkaloids with reduced impurity formation - The invention provides processes for the production of opiate alkaloids. In particular, the present invention provides processes for the formation of opiate alkaloids that minimizes the formation of impurities. | 04-01-2010 |
20100081814 | Processes for increasing the yield of opiate alkaloid derivatives - The present invention provides processes for the production of opiate alkaloids. In particular, the present invention provides processes for recycling impurities into useful intermediates during the synthesis of opiate alkaloids. | 04-01-2010 |
20100081815 | Recycling process for increasing the yield of opiate alkaloid derivatives - The present invention provides processes for the production of opiate alkaloids. In particular, the present invention provides processes for increasing the yield of opiate alkaloids by introducing at least one recycling step. | 04-01-2010 |
20100081816 | Processes for synthesis of opiate alkaloid derivatives - The present invention provides processes for the synthesis of opiate alkaloids. In particular, the opiate alkaloids produced by the process of the invention are typically intermediate compounds that may be utilized to produce a variety of biologically active alkaloids including buprenorphine and diprenorphine. | 04-01-2010 |
20100087647 | Processes for the production of buprenorphine with reduced impurity formation - The present invention provides process for the production of opiate alkaloids. In particular, the present invention provides processes for the production of buprenorphine or a derivative of buprenorphine that minimizes the formation of impurities. | 04-08-2010 |
20100274019 | PROCESS FOR PREPARING OXYMORPHONE, NALTREXONE, AND BUPRENORPHINE - Methods are provided which include converting oripavine to other opiates, including converting oripavine to naltrexone, buprenorphine, 14-hydroxymorphinone and/or converting 14-hydroxymorphinone to oxymorphone. Purification and salt formation are optionally included. | 10-28-2010 |
20110009633 | Method for the Enrichment of Buprenorphine using Chromatographic Techniques - The present invention provides processes for the enrichment of buprenorphine in a product. In particular, the present invention provides processes for the enrichment of buprenorphine in a product using chromatographic techniques. | 01-13-2011 |
20110152527 | PROCESS FOR THE PREPARATION OF MORPHINE ANALOGUES - The present invention relates to an improved process for preparing morphinane analogues of formula (1) wherein the substituents R | 06-23-2011 |
20110313163 | Methods for One-Pot N-Demethylation/N-Functionalization of Morphine and Tropane Alkaloids - The present invention provides a method for the N-demethylation and N-functionalization of an N-methylated heterocycle such as a morphine alkaloid or tropane alkaloid. The method comprises reacting the heterocycle with an functionalization agent in the presence of a transition metal catalyst in air or in the presence of an oxidant. | 12-22-2011 |
20120046465 | Processes for the Preparation of Morphinane and Morphinone Compounds - The present application describes processes for the synthesis of morphinane and morphinone compounds, useful as pharmaceutical agents. Also included are novel intermediates useful in the preparation of these compounds. The process comprises quaternization of oripavine to provide a mixture of the R- and S-isomeric (at the nitrogen) quaternary salts. The R-isomer is readily isolated and converted to various N-(R)-morphinane and N-(S)-morphinone compounds. The R-isomer, S-isomer or a mixture of R- and S-isomers may be demethylated and converted to various morphinane and morphinone compounds. | 02-23-2012 |
20120283443 | Processes and Intermediates in the Preparation of Morphine Analogs via N-Demethylation of N-Oxides Using Cyclodehydration Reagents - A high-yielding method for the N-demethylation of oxycodone- and oxymorphone-N-oxides by the reaction of these compounds with cyclodehydration reagents has been performed. This method has been utilized to improve the synthesis of various morphine analogs, such as naltrexone, nalbuphone and naloxone. | 11-08-2012 |
20130102784 | PROCESS FOR N-DEALKYLATION OF TERTIARY AMINES - The present disclosure provides improved methods for N-dealkylation of tertiary amines, including methods for N-demethylation of alkaloids and opioids, in which the dealkylation reaction is carried out in a solvent comprising a tertiary alcohol. The present disclosure also provides improved processes for preparing semi-synthetic opioids that incorporate the disclosed methods for N-dealkylation of tertiary amines. | 04-25-2013 |
20140031550 | PROCESS FOR THE PREPARATION OF MORPHINANE ANALOGUES - The present invention relates to an improved process for preparing morphinane analogues of formula 1 | 01-30-2014 |
20140364612 | INDUSTRIAL PROCESS FOR THE PREPARATION OF BUPRENORPHINE AND ITS INTERMEDIATES - There is provided an efficient industrial process for the preparation of 21-cyclopropyl-7α-(2-hydroxy-3,3-dimethyl-2-butyl)-6,14-endo-ethano-6,7,8,14-tetrahydro-oripavine, i.e. buprenorphine of Formula-I in high yield and purity, with enhanced safety and eco-friendly norms. The invention further relates to an improved process for preparation of intermediates thereof in high yield and purity. | 12-11-2014 |
20150087839 | PROCESS FOR N-DEALKYLATION OF TERTIARY AMINES - The present disclosure provides improved methods for N-dealkylation of tertiary amines, including methods for N-demethylation of alkaloids and opioids, in which the dealkylation reaction is carried out in a solvent comprising a tertiary alcohol. The present disclosure also provides improved processes for preparing semi-synthetic opioids that incorporate the disclosed methods for N-dealkylation of tertiary amines. | 03-26-2015 |
20150133664 | CHEMICAL TRANSFORMATIONS OF (-)-CODEINE TO AFFORD DERIVATIVES OF CODEINE AND MORPHINE THEREOF - The present invention relates to methods for the synthesis of morphine, codeine, intermediates, salts and derivatives thereof. In preferred embodiments, the invention relates to methods for improving the efficiency, steroselectivity, and overall yield of said codeine and morphine related derivatives and intermediates thereof. The present invention relates to new codeine and morphine related derivative compositions. | 05-14-2015 |
20150133665 | PROCESSES AND INTERMEDIATES IN THE PREPARATION OF MORPHINE ANALOGS VIA N-DEMETHYLATION OF N-OXIDES USING CYCLODEHYDRATION REAGENTS - A high-yielding method for the N-demethylation of oxycodone- and oxymorphone-N-oxides by the reaction of these compounds with cyclodehydration reagents has been performed. This method has been utilized to improve the synthesis of various morphine analogs, such as naltrexone, nalbuphone and naloxone. | 05-14-2015 |
20160008286 | BUPRENORPHINE NANOPARTICLE COMPOSITION AND METHODS THEREOF | 01-14-2016 |
20160159813 | PROCESS FOR N-DEALKYLATION OF TERTIARY AMINES - The present disclosure provides improved methods for N-dealkylation of tertiary amines, including methods for N-demethylation of alkaloids and opioids, in which the dealkylation reaction is carried out in a solvent comprising a tertiary alcohol. The present disclosure also provides improved processes for preparing semi-synthetic opioids that incorporate the disclosed methods for N-dealkylation of tertiary amines. | 06-09-2016 |
546040000 | Plural ring nitrogens in the hexacyclo ring system (e.g., reserpic acid lactone, etc.) | 10 |
20080242864 | Process for the Semisynthesis of Deserpidine - The present invention relates to an efficient procedure for the synthesis of deserpidine (Ia), starting from reserpic acid lactone (II) via the intermediate 11-O-demethyl reserpic acid lactone (III). | 10-02-2008 |
20080262232 | PROCESSES FOR THE PRODUCTION OF POLYMORPHIC FORMS OF RIFAXIMIN - Crystalline polymorphous forms of rifaximin (INN) antibiotic named rifaximin α and rifaximin β, and a poorly crystalline form named rifaximin γ, useful in the production of medicinal preparations containing rifaximin for oral and topical use and obtained by means of a crystallization carried out by hot-dissolving the raw rifaximin in ethyl alcohol and by causing the crystallization of the product by addition of water at a determinate temperature and for a determinate period of time, followed by a drying carried out under controlled conditions until reaching a settled water content in the end product, are the object of the invention. | 10-23-2008 |
20110098474 | PROCESS FOR THE SYNTHESIS OF MORPHINANE COMPOUNDS AND INTERMEDIATES THEREOF - This invention relates to intermediates useful in the preparation of opiate alkaloids, particularly morphinane compounds. The invention also relates to processes for preparing such intermediates and to processes which utilise such intermediates in the synthesis of morphinane compounds. | 04-28-2011 |
20120203000 | POLYMORPHIC FORMS ALPHA, BETA AND GAMMA OF RIFAXIMIN - Crystalline polymorphous forms of rifaximin (INN) antibiotic named rifaximin α and rifaximin β, and a poorly crystalline form named rifaximin γ, useful in the production of medicinal preparations containing rifaximin for oral and topical use and obtained by means of a crystallization carried out by hot-dissolving the raw rifaximin in ethyl alcohol and by causing the crystallization of the product by addition of water at a determinate temperature and for a determinate period of time, followed by a drying carried out under controlled conditions until reaching a settled water content in the end product, are the object of the invention. | 08-09-2012 |
20120245355 | POLYMORPHOUS FORMS OF RIFAXIMIN, PROCESSES FOR THEIR PRODUCTION AND USE THEREOF IN THE MEDICINAL PREPARATIONS - Crystalline polymorphous forms of the rifaximin (INN) antibiotic named rifaximin δ and rifaximin ε useful in the production of medicinal preparations containing rifaximin for oral and topical use and obtained by means of a crystallization process carried out by hot-dissolving the raw rifaximin in ethyl alcohol and by causing the crystallization of the product by addition of water at a determinate temperature and for a determinate period of time, followed by a drying carried out under controlled conditions until reaching a settled water content in the end product, are the object of the invention. | 09-27-2012 |
20130066079 | FORMS OF RIFAXIMIN AND USES THEREOF - The present invention relates to Rifaximin polymorphic, salt, hydrate, and amorphous forms, to their use in medicinal preparations and to therapeutic methods using them. | 03-14-2013 |
20130281697 | POLYMORPHIC FORMS ALPHA, BETA AND GAMMA OF RIFAXIMIN - Crystalline polymorphous forms of rifaximin (INN) antibiotic named rifaximin α and rifaximin β, and a poorly crystalline form named rifaximin γ, useful in the production of medicinal preparations containing rifaximin for oral and topical use and obtained by means of a crystallization carried out by hot-dissolving the raw rifaximin in ethyl alcohol and by causing the crystallization of the product by addition of water at a determinate temperature and for a determinate period of time, followed by a drying carried out under controlled conditions until reaching a settled water content in the end product, are the object of the invention. | 10-24-2013 |
20130317225 | NEW FORMS OF RIFAXIMIN AND USES THEROF - The present invention relates to new rifaximin forms kappa, theta, rifaximin:piperazine cocrystal 1 and rifaximin:piperazine cocrystal 2, methods of making same and to their use in medicinal preparations and therapeutic methods. | 11-28-2013 |
20140012001 | NOVEL POLYMORPHIC FORM OF RIFAXIMIN AND PROCESS FOR ITS PREPARATION - The present invention discloses a stable amorphous form of Rifaximin characterised by having X-ray powder diffraction pattern as given in FIG. | 01-09-2014 |
20150011767 | USE OF KOUMINE AND ITS HOMOLOGUES IN PREPARATION OF MEDICAMENT FOR TREATMENT OF AUTOIMMUNE DISEASES OF INVOLVED BONES AND JOINTS - The present invention discloses an application of koumine and homologue thereof in preparation of drugs for treating autoimmune diseases involving bones and joints including rheumatoid arthritis, spondylitis ankylopoietica or the like, in particular an application of | 01-08-2015 |
546041000 | Plural ring hetero atoms in the hexacyclo ring system | 4 |
20090306386 | Plant Extract Obtained by an Extraction Method by Means of Solvents of Plant Origin - The invention relates to a plant extract obtained by a single-phase extraction method, by means of a solvent and/or a mixture of solvents of plant origin, containing characterised and chemically defined constituents. Said plant extract is characterised in that it is free of polyphenol, anthocyan and/or tannin, and comprises a fraction of lipophile-type components and/or a fraction of polar-type components. The invention also relates to an extraction method which enables an inventive extract to be obtained, said method being a single-phase extraction method characterised in that it comprises the following steps: a plant material is brought into contact with a solvent and/or a mixture of solvents of plant origin, containing characterised and chemically defined constituents; the plant material is eliminated; and the solvent and/or mixture of solvents is partially or completely eliminated. Said solvent and/or at least one of the constituents of the mixture of solvents is selected from the group of terpenic solvents having a purity which is at least equal to 98% and being depleted of peroxides. | 12-10-2009 |
20120253045 | Sulfur Containing Heterocycle-Fused Naphthalene Tetracarboxylic Acid Diimide Derivatives, Preparation Method And Use Thereof - Sulfur containing heterocycle-fused naphthalenetetracarboxylic acid diimide derivatives represented by formula (I) are disclosed, | 10-04-2012 |
20130231484 | COMPOUNDS HAVING PHOTOCHEMICALLY REMOVABLE PROTECTING GROUPS BASED ON AN ELECTROCYCLIC REACTION BETWEEN A CHROMOPHORE ATTACHED VIA AN ANILIDE GROUP TO A BENZOTHIOPHENE RING - Disclosed herein are compounds having photoremovable protecting groups which are removed after the compounds absorbs light of a given wavelength and undergo an electrocyclic reaction between a chromophore in the compound attached via an anilide to a benzothiophene ring. | 09-05-2013 |
20150303382 | Bay-Annulated Indigo (BAI) As An Excellent Electron Accepting Building Block for High Performance Organic Semiconductors - A novel electron acceptor based on bay-annulated indigo (BAI) was synthesized and used for the preparation of a series of high performance donor-acceptor small molecules and polymers. The resulting materials possess low-lying LUMO energy level and small HOMO-LUMO gaps, while their films exhibited high crystallinity upon thermal treatment, commensurate with high field effect mobilities and ambipolar transfer characteristics. | 10-22-2015 |