Class / Patent application number | Description | Number of patent applications / Date published |
544360000 | Six-membered ring consisting of one nitrogen and five carbons (e.g., pyridine, etc.) | 53 |
20080214815 | Process for preparing phenoxypyridine derivatives - A process for preparing a compound represented by the formula (I): | 09-04-2008 |
20080221327 | SYNTHESIS OF GLYT-1 INHIBITORS - The present invention relates to a process for preparation of a compound of formula I | 09-11-2008 |
20090137806 | DUAL NK1/NK3 RECEPTOR ANTAGONISTS - The present invention provides a method for the treatment of schizophrenia which comprises administering a compound of formula | 05-28-2009 |
20090149652 | Derivatives of 4-aminopiperidine and their use as a medicament - A subject of the present application is new derivatives of 4-aminopiperidines of formula | 06-11-2009 |
20090306383 | Method for Producing 2-(4-Methyl-2-Phenylpiperazin-1-Yl)Pyridine-3-Methanol - The present invention provides a method for producing 2-(4-methyl-2-phenylpiperazin-1-yl)pyridine-3-methanol, and this method includes the step of catalytically reducing 2-(4-methyl-2-phenylpiperazin-1-yl)-3-cyanopyridine in the presence of a partially deactivated palladium catalyst in an aqueous acid solution. | 12-10-2009 |
20100036125 | SYNTHESIS OF CCR5 RECEPTOR ANTAGONISTS - The present invention is directed to the synthesis of 4-[4-[(R)-[1-[cyclopropylsulfonyl)-4-piperidinyl](3-fluorophenyl)methyl]-3(S)-methyl- | 02-11-2010 |
20100311971 | SOLID FORMS OF [4-(3-FLUORO-5-TRIFLUOROMETHYL-PYRIDIN-2-YL)-PIPERAZIN-1-YL-[5-METHANESUL- FONYL-2-((S)-2,2,2-TRIFLUORO-1-METHYL-ETHOXY)-PHENYL]-METHANONE - The present invention relates to four distinct crystalline forms and to an amorphous form of [4-(3-Fluoro-5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-[5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-methanone, and to their use in the preparation of pharmaceutical compositions. The compounds of present invention are suitable for the treatment of psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia, dementia and other diseases in which cognitive processes are impaired, such as attention deficit disorders or Alzheimer's disease. | 12-09-2010 |
20110275815 | BENZYLPIPERAZINE DERIVATIVES AS MOTILIN RECEPTOR ANTAGONISTS - The invention relates to compounds of formula (I): | 11-10-2011 |
20110295007 | SOLID FORMS OF [4-(3-FLUORO-5-TRIFLUOROMETHYL-PYRIDIN-2-YL)-PIPERAZIN-1-YL-[5-METHANESUL- FONYL-2-((S)-2,2,2-TRIFLUORO-1-METHYL-ETHOXY)-PHENYL]-METHANONE - The present invention relates to four distinct crystalline forms and to an amorphous form of [4-(3-Fluoro-5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-[5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-methanone, and to their use in the preparation of pharmaceutical compositions. The compounds of present invention are suitable for the treatment of psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia, dementia and other diseases in which cognitive processes are impaired, such as attention deficit disorders or Alzheimer's disease. | 12-01-2011 |
20120136152 | EFFICIENT SYNTHETIC METHOD OF 18F-MEFWAY PRECURSOR - The present invention relates a novel method for preparing an | 05-31-2012 |
20120309969 | SOLID FORMS OF [4-(3-FLUORO-5-TRIFLUOROMETHYL-PYRIDIN-2-YL)-PIPERAZIN-1-YL-[5-METHANESUL- FONYL-2-((S)-2,2,2-TRIFLUORO-1-METHYL-ETHOXY)-PHENYL]-METHANONE - The present invention relates to four distinct crystalline forms and to an amorphous form of [4-(3-Fluoro-5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-[5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-methanone, and to their use in the preparation of pharmaceutical compositions. The compounds of present invention are suitable for the treatment of psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia, dementia and other diseases in which cognitive processes are impaired, such as attention deficit disorders or Alzheimer's disease. | 12-06-2012 |
20130197225 | New Solid Forms of [4-(3-Fluoro-5-Trifluoromethyl-Pyridin-2-Yl)-Piperazin-1-Yl-[5-Methanesul- fonyl-2-((S)-2,2,2-Trifluoro-1-Methyl-Ethoxy)-Phenyl]Methanone - The present invention relates to four distinct crystalline forms and to an amorphous form of [4-(3-Fluoro-5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-[5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-methanone, and to their use in the preparation of pharmaceutical compositions. The compounds of present invention are suitable for the treatment of psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia, dementia and other diseases in which cognitive processes are impaired, such as attention deficit disorders or Alzheimer's disease. | 08-01-2013 |
20130338361 | RADIOFLUORINATION METHOD - Provided by the present invention is a novel method for obtaining an | 12-19-2013 |
20150133663 | NOVEL SYNTHESIS METHOD - The present invention relates to a method of making compounds having affinity for the 1 A subtype of the serotonin receptor, i.e. 5HT | 05-14-2015 |
20150344452 | PROCASPASE ACTIVATING COMPOUNDS - Compositions and methods are disclosed in embodiments relating to induction of cell death such as in cancer cells. Compounds and related methods for synthesis and use thereof, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells are disclosed. Compounds are disclosed that have lower neurotoxicity effects than other compounds. | 12-03-2015 |
20160016906 | SALT OF OMECAMTIV MECARBIL AND PROCESS FOR PREPARING SALT - Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use. Omecamtiv mecarbil (AMG 423, CK-1827452), having the structure: | 01-21-2016 |
544361000 | The additional six-membered hetero ring is one of the cyclos in a polycyclo ring system | 20 |
20090111987 | Imino-Indeno[1,2-c] quinoline derivatives, their preparation processes, and pharmaceutical compositions comprising the same - Disclosed herein are novel imino-indeno[1,2-c]quinoline derivatives of formula (I): | 04-30-2009 |
20100099871 | ANTI-PSYCHOTIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONSTHEREOF - Compounds having anti-psychotic activity are disclosed herein. In some embodiments, the compounds are atypical anti-psychotics. In some embodiments, the compounds are selective for the 5-HT | 04-22-2010 |
20100113783 | PROCESS FOR THE PREPARATION OF CRYSTALS OF PRULIFLOXACIN - The present invention relates to processes for the preparation of Type I, Type II and Type III crystals of prulifloxacin. | 05-06-2010 |
20100261901 | SELECTIVE BROMINATION OF PERYLENE DIIMIDES AND DERIVATIVES THEREOF UNDER MILD CONDITIONS - The present invention is directed to novel process for the preparation of regioselective perylenediimides derivatives, specifically mono and dibrominated derivatives. | 10-14-2010 |
20110034690 | PROCESS FOR THE PREPARATION OF PURE PRULIFLOXACIN - The present invention relates to a process for the preparation of prulifloxacin. The present invention further relates to prulifloxacin having purity of about 99% or above. | 02-10-2011 |
20130231481 | SELECTIVE BROMINATION OF PERYLENE DIIMIDES AND DERIVATIVES THEREOF UNDER MILD CONDITIONS - The present invention is directed to novel process for the preparation of regioselective perylenediimides derivatives, specifically mono and dibrominated derivatives. | 09-05-2013 |
20130345426 | TETRAHYDROCARBOLINE DERIVATIVE - An object of the present invention is to provide a drug having the inhibitory activity on ENPP2 which is a different target from that of the existing drug, as a medicament useful in a urinary excretion disorder patient for whom the existing drug has the insufficient effect. | 12-26-2013 |
20160031884 | TETRAHYDROCARBOLINE DERIVATIVE - An object of the present invention is to provide a drug having the inhibitory activity on ENPP2 which is a different target from that of the existing drug, as a medicament useful in a urinary excretion disorder patient for whom the existing drug has the insufficient effect. The present invention provides a compound represented by the general formula (I): | 02-04-2016 |
544362000 | The additional six-membered hetero ring is one of the cyclos in a bicyclo ring system | 12 |
20090312549 | METHOD OF PREPARATION OF AZAINDOLE DERIVATIVES - A method of preparing azaindole compounds for antiviral use having the formula | 12-17-2009 |
20110319619 | NOVEL 1,6-DISUBSTITUTED-3-AMINO-4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[3,4-C]PYRID- IN-7-ONE COMPOUNDS AND PREPARATION THEREOF - Provided are a novel 1,6-disubstituted-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridin-7-one compound, a pharmaceutically acceptable salt compound thereof, a method for preparing the compound, and an anticancer pharmaceutical composition including the compound as an effective ingredient. | 12-29-2011 |
20130096305 | DEUTERATED HIV ATTACHMENT INHIBITORS - Deuterated piperazine and piperidine HIV attachment inhibitor compounds are set forth. The present invention provides compounds of Formula I, the pharmaceutically acceptable salts and/or solvates (e.g., hydrates) thereof, their pharmaceutical formulations, and their use in patients suffering from or susceptible to a virus such as HIV. The compounds of Formula I, their pharmaceutically acceptable salts and/or solvates are effective antiviral agents, particularly as inhibitors of HIV. They are useful for the treatment of HIV and AIDS. | 04-18-2013 |
20130253197 | FUSED BICYCLIC KINASE INHIBITORS - Compounds of Formula I, as shown below and defined herein: | 09-26-2013 |
20140221653 | Prodrugs of NH-Acidic Compounds - The invention provides a method of sustained delivery of a lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug by administering to a patient an effective amount of a prodrug compound of the invention wherein upon administration to the patient, release of the parent drug from the prodrug is sustained release. Prodrug compounds suitable for use in the methods of the invention are labile conjugates of parent drugs that are derivatized through carbonyl linked prodrug moieties. The prodrug compounds of the invention can be used to treat any condition for which the lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug is useful as a treatment. | 08-07-2014 |
20140275540 | Processes For The Preparation Of An Apoptosis-Inducing Agent - Provided herein is a process for the preparation of an apoptosis-inducing agent, and chemical intermediates thereof. Also provided herein are novel chemical intermediates related to the process provided herein. | 09-18-2014 |
20150025240 | SALTS OF PRODRUGS OF PIPERAZINE AND SUBSTITUTED PIPERIDINE ANTIVIRAL AGENTS - This invention provides for prodrug Compounds I, pharmaceutical compositions thereof, and their use in treating HIV infection. | 01-22-2015 |
20150038712 | METHODS FOR THE PREPARATION OF HIV ATTACHMENT INHIBITOR PIPERAZINE PRODRUG COMPOUND - A method for making the compound | 02-05-2015 |
20150322064 | Heterocyclic Compounds and Uses Thereof - Heterocyclic entities that modulate PI3 kinase activity, pharmaceutical compositions containing the heterocyclic entities, and methods of using these chemical entities for treating diseases and conditions associated with PI3 kinase activity are described herein. | 11-12-2015 |
20150329540 | OCT3 ACTIVITY INHIBITOR CONTAINING IMIDAZOPYRIDINE DERIVATIVE AS ACTIVE COMPONENT, AND OCT3 DETECTION AGENT - [Problem] To provide an OCT3 activity inhibitor having a different basic skeleton than that of conventional OCT3 activity inhibitors. | 11-19-2015 |
20150329543 | PRODRUGS OF SUBSTITUTED AZAINDOLEOXOACETIC PIPERAZINE DERIVATIVES - This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS. | 11-19-2015 |
20160152615 | PRODRUGS OF SUBSTITUTED AZAINDOLEOXOACETIC PIPERAZINE DERIVATIVES | 06-02-2016 |
544364000 | At least three hetero rings containing | 13 |
20080207904 | Imatinib base, and imatinib mesylate and processes for preparation thereof - The present invention provides crystalline forms of imatinib base, imatinib base free of desmethyl imatinib, and imatinib mesylate free of desmethyl imatinib mesylate, processes of their preparation and pharmaceutical compositions of imatinib mesylate. | 08-28-2008 |
20090118509 | PREPARATION OF [2-METHYL-5-PHENYL-3-(PIPERAZIN-1-YLMETHYL)] PYRROLE DERIVATIVES - A process for the preparation of compounds of Formula I and their pharmaceutically acceptable acid addition salt | 05-07-2009 |
20090192311 | CRYSTALLINE AND AMORPHOUS 4-CYANO-N--N-PYRIDIN-2-YL-BENZAMIDE HYDROCHLORIDE - The present invention is directed to crystal and amorphous forms of the 5-HT | 07-30-2009 |
20100121063 | PROCESS FOR THE SYNTHESIS OF 2-AMINOTHIAZOLE COMPOUNDS AS KINASE INHIBITORS - The present invention relates to an industrial process of preparing pharmaceutical compounds having the formula (1) which are useful as certain tyrosine kinase inhibitors and more particularly as c-kit and bcr-abl inhibitors. The groups R1 and R2, identical or different, represent each a hydrogen, halogen atom, an alkyl, an alkoxy, a trifluoromethyl, an amino, an alkylamino, a dialkylamino, a solubilising group; m is 0-5 and n is 0-4; the group R3 represents an aryl or an heteroaryl group as described in claims herein. | 05-13-2010 |
20100145047 | INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE - Provided herein are compounds of the formula (I): | 06-10-2010 |
20100234599 | METHOD FOR PREPARING ACID ADDITION SALTS OF POLYACIDIC BASIC COMPOUNDS - This invention relates to a method for preparing an acid addition salt of a polyacidic basic compound, or a water adduct having basic site(s) stronger than pyridine. The method comprises reacting the polyacidic basic compound with an acid salt of pyridine. | 09-16-2010 |
20100311972 | METHOD FOR PRODUCING PHENOXYPYRIDINE DERIVATIVE - A method for producing a compound represented by the formula (I) | 12-09-2010 |
20120209001 | PIPERAZINYL-PROPYL-PYRAZOLE DERIVATIVES AS DOPAMINE D4 RECEPTOR ANTAGONISTS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME - The present invention relates to a novel piperazinyl-propyl-pyrazole derivative, a method of its preparation and a pharmaceutically acceptable composition comprising the same. The novel piperazinyl-propyl-pyrazole derivative of the present invention has superior selective affinity for dopamine D | 08-16-2012 |
20130066075 | PROPHYLACTIC AND/OR THERAPEUTIC AGENT FOR NON-ALCOHOLIC STEATOHEPATITIS - Provided is a compound useful in the prevention and treatment of non-alcoholic steatohepatitis. A prophylactic and/or therapeutic agent for non-alcoholic steatohepatitis which contains, as the active ingredient, 2-[4-[2-(benzimidazol-2-ylthio)ethyl]piperazin-1-yl]-N-[2,4-bis(methylthio)-6-methyl-3-pyridyl]acetamide, an acid-addition salt thereof, or a solvate of the same. | 03-14-2013 |
20140011999 | Method for Producing Phenoxypyridine Derivative - A method for producing a compound or a salt thereof represented by a formula (I), comprising reacting a compound or a salt thereof represented by a formula (II) and an aniline derivative represented by a formula (III) in water or a mixed solvent of water and an organic solvent in the presence of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide and substantially in the absence of a base is disclosed, | 01-09-2014 |
20140046063 | TREATMENT OF SERVICE PERSISTANT ASTHMA WITH MASITINIB - The present invention relates to the treatment of severe persistent asthma, and in particular severe persistent corticosteroid-dependent or corticosteroid-resistant asthma, comprising administration a tyrosine kinase inhibitor or a mast cell inhibitor, especially masitinib or a pharmaceutically acceptable salt thereof. | 02-13-2014 |
20140235859 | PROCESS FOR THE RESOLUTION OF OMEPRAZOLE - The present invention relates to process for the resolution of omeprazole. The present invention further provides a novel compound of enantiomers of omeprazole cyclic amine salt and a process for preparing it. The present invention also provides a solid of (R)- or (S)-omeprazole cyclic amine salt and a process for preparing it. The present invention also provides a process for the preparation of esomeprazole magnesium dihydrate substantially free of its trihydrate form. The present invention also provides a process for the preparation of recovery of chiral BINOL. | 08-21-2014 |
20150299180 | NEUROPROTECTIVE AGENTS FOR TREATMENT OF NEURODEGENERATIVE DISEASES - A compound having formula I is useful for treating a neurodegenerative disease: | 10-22-2015 |
544365000 | Having -C(=X)-, wherein X is chalcogen, bonded directly to ring carbon of the additional six-membered hetero ring (e.g., nicotinic acid, etc.) | 4 |
20110201811 | DIHYDROPYRIDINE CALCIUM ANTAGONIST COMPOUNDS, PREPARATION METHODS, AND MEDICAL USES THEREOF - A dihydropyridine (DHP) calcium antagonist compound and its preparation method and medical use are related to preparation methods of compounds of general formulas (I) and (II) as shown below and their pharmaceutical salts and applications for treating cardiovascular diseases, and R | 08-18-2011 |
20130005974 | SYNTHESIS OF A NEUROSTIMULATIVE PIPERAZINE - The invention describes an improved synthesis for piperazine derivatized with nicotinic acid and a benzyl moiety. The product compounds are useful for treatment of neurological conditions. | 01-03-2013 |
20130012709 | NOVEL INHIBITORS OF STEAROYL-CoA-DESATURASE-1 AND THEIR USES - An inhibitor of the activity of stearoyl-CoA-desaturase-1 (SCD-1) enzyme for use in the treatment of prostate cancer as well as novel inhibitors of formula (IIa). | 01-10-2013 |
20160090358 | SYNTHESIS OF A NEUROSTIMULATIVE PIPERAZINE - The invention describes an improved synthesis for piperazine derivatized with nicotinic acid and a benzyl moiety. The product compounds are useful for treatment of neurological conditions. | 03-31-2016 |