Class / Patent application number | Description | Number of patent applications / Date published |
544133000 | The five-membered hetero ring has at least sulfur and nitrogen as ring hetero atoms | 28 |
20080312435 | Imine Compound - An imine compound represented by the formula: | 12-18-2008 |
20090198054 | PREPARATION OF THIAZOLES - The present disclosure is directed to a process for the preparation of a compound having the formula: | 08-06-2009 |
20090286975 | Indole compound - The purpose of the present invention is to provide a glucokinase activator useful as a pharmaceutical agent such as an agent for the prophylaxis or treatment of diabetes, obesity and the like. | 11-19-2009 |
20100004441 | N-(5-Membered Aromatic Ring)-Amido Anti-Viral Compounds - Disclosed are compounds having Formula (I) and the compositions and methods thereof for treating or preventing a viral infection mediated at least in part by a virus in the Flaviviridae family of viruses, wherein A, R | 01-07-2010 |
20100094002 | Thiazole Compound and Use Thereof - Thiazole compounds for inhibiting the activity of phosphodiesterase 4, the production of tumor necrosis factor alpha, and the production of interleukin 4. The compounds of the invention are represented by general formula (1): | 04-15-2010 |
20100240890 | Novel benzamidine derivatives, process for the preparation thereof and pharmaceutical composition comprising the same - The present invention relates to novel benzamidine derivatives, process for the preparation thereof and pharmaceutical composition comprising the same. The novel benzamidine derivatives of the present invention are useful for the prevention and treatment of osteoporosis, bone fractures and allergic inflammatory diseases. | 09-23-2010 |
20110190492 | DIAGNOSTIC PROBE FOR CONFORMATION DISEASE - The invention provides a probe compound useful for early diagnosis of conformation disease, a composition and a kit comprising it for diagnosis for conformation disease, and a medical composition for treatment and/or prevention of conformation disease. | 08-04-2011 |
20110319616 | THIAZOLE DERIVATIVE AND PROCESS FOR PRODUCING SAME - An object is to provide a thiazole derivative produced from easily available raw materials by a simplified production process. Provided are a process for producing a novel thiazole derivative represented by the general formula (I), which is characterized by adding a strong base to a thioamide represented by the general formula (II) and reacting the mixture with a thioformamide represented by the general formula (III), and a novel thiazole derivative. | 12-29-2011 |
20140088304 | METHODS AND INTERMEDIATES FOR PREPARING PHARMACEUTICAL AGENTS - The invention provides methods and intermediates that are useful for preparing a compound of formula I: | 03-27-2014 |
20140155597 | AMIDINE COMPOUND OR SALT THEREOF - The purpose of the present invention is to provide a novel compound which has an anti-fungal activity on pathogenic fungi including fungi belonging to the genus | 06-05-2014 |
20140187771 | AMORPHOUS SOLID SALTS - The invention provides an amorphous solid of a compound of formula (I) or of a salt thereof as well as compositions comprising the amorphous solids, and methods for making and using the amorphous solids. | 07-03-2014 |
20140243525 | IMIDAZOLOTHIAZOLE COMPOUNDS FOR THE TREATMENT OF DISEASE - Compounds, compositions and methods are provided for modulating the activity of receptor kinases and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder mediated by receptor kinases. | 08-28-2014 |
20140364602 | METHODS AND INTERMEDIATES FOR PREPARING PHARMACEUTICAL AGENTS - Methods and intermediates useful for preparing a compound of formula I: | 12-11-2014 |
20150080570 | ALPHA,BETA-UNSATURATED MONOMERS CAPABLE OF MULTIMERIZATION IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME - Described herein are monomers capable of forming a biologically useful multimer when in contact with one, two, three or more other monomers in an aqueous media. In one aspect, such monomers may be capable of binding to another monomer in an aqueous media (e.g. in vivo) to form a multimer, (e.g. a dimer). Contemplated monomers may include a ligand moiety, a linker element, and a connector element that joins the ligand moiety and the linker element. In an aqueous media, such contemplated monomers may join together via each linker element and may thus be capable of modulating one or more biomolecules substantially simultaneously, e.g., modulate two or more binding domains on a protein or on different proteins. | 03-19-2015 |
20150133656 | NOVEL BICYCLIC THIAZOLE COMPOUNDS - The present invention relates to novel bicyclic thiazole compounds that inhibit Traf2- and Nck-interacting kinase (TNIK), and as such are useful as TNIK inhibitors administered to cancer patients, especially to solid cancer patients such as colorectal cancer, pancreatic cancer, non-small cell lung cancer, prostate cancer or breast cancer. The bicyclic thiazole compounds are showed by a next formula (I). (wherein R | 05-14-2015 |
20160002186 | METHODS AND INTERMEDIATES FOR PREPARING PHARMACEUTICAL AGENTS - The invention provides methods and intermediates that are useful for preparing a compound of formula I: | 01-07-2016 |
544134000 | Plural sulfurs or nitrogens in the five-membered hetero ring (e.g., thiatriazole, etc.) | 5 |
20120289698 | CERTAIN HETEROCYCLES, COMPOSITIONS THEREOF, AND METHODS FOR THEIR USE - Provided are compounds of Formula I: | 11-15-2012 |
20130060025 | CERTAIN HETEROCYCLES, COMPOSITIONS THEREOF, AND METHODS FOR THEIR USE - Provided are compounds of Formula I: | 03-07-2013 |
20140039183 | SELECTIVE HETEROCYCLIC SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS - Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such compounds are provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated. | 02-06-2014 |
20140094603 | MITOTIC KINESIN INHIBITORS AND METHODS OF USE THEREOF - This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders. | 04-03-2014 |
20140330011 | CERTAIN HETEROCYCLES, COMPOSITIONS THEREOF, AND METHODS FOR THEIR USE - Provided are compounds of Formula I: | 11-06-2014 |
544135000 | Benzothiazoles (including hydrogenated) | 7 |
20110251386 | ACETIC ACID AMIDE DERIVATIVE HAVING INHIBITORY ACTIVITY ON ENDOTHELIAL LIPASE - Disclosed is a compound which is useful as an endothelial lipase inhibitor. | 10-13-2011 |
20120035360 | DUAL-COLOR IMAGING METHOD OF SODIUM/CALCIUM ACTIVITIES USING TWO-PHOTON FLUORESCENT PROBES AND PREPARATION METHOD OF TWO-PHOTON FLUORESCENT PROBES - Provided are a method for dual-color imaging of sodium/calcium activities using a two-photon fluorescent probe and a method for preparing the two-photon fluorescent probe. The disclosed two-photon fluorescent probe for detecting calcium ions near the cell membrane reacts with calcium cations to exhibit strong two-photon fluorescence and may be selectively and easily loaded into the cell membrane by forming a complex with a calcium ion. Further, it allows imaging of the distribution of calcium cations in a living cell or tissue since it can selectively detect calcium ions in the living cell or tissue at a depth of 100 to 200 μm for more than 60 minutes. In addition, by staining the living cell or tissue with two probes of different fluorescent colors, the calcium and sodium activities can be imaged simultaneously at different channels. | 02-09-2012 |
20120253040 | OXADIAZOLE DERIVATIVE HAVING ENDOTHELIAL LIPASE INHIBITORY ACTIVITY - Disclosed is a compound which is useful as an endothelial lipase inhibitor. | 10-04-2012 |
20130005966 | PROCESS FOR THE PREPARATION OF IMIDAZO[2,1-B][1,3]BENZOTHIAZOLE DERIVATIVES - Provided herein are process for the preparation of N-(5-ferf-butyl-isoxazol-3-yl)-N′-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-fe][1,3]benzothiazol-2-yl]phenyl}urea, or a pharmaceutically acceptable salt, solvate, hydrate, or polymorph thereof. N-(5-tert-Butyl-isoxazol-3-yl)-N′-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-&][1,3]benzo-thiazol-2-yl]phenyl}urea is useful for treating, preventing, and/or managing diseases or conditions, including but not limited to, proliferative diseases, FLT-3 mediated diseases, and cancers. N-(5-ferf-Butyl-isoxazol-3-yl)-N′-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-&][1,3]benzothiazol-2-yl]phenyl}urea is represented by the structure: | 01-03-2013 |
20140288302 | ACETIC ACID AMIDE DERIVATIVE HAVING INHIBITORY ACTIVITY ON ENDOTHELIAL LIPASE - A pharmaceutical composition including a compound of formula (I): | 09-25-2014 |
20140323722 | OXADIAZOLE DERIVATIVE HAVING ENDOTHELIAL LIPASE INHIBITORY ACTIVITY - A compound represented by formula: | 10-30-2014 |
20150344484 | NOVEL 6-TRIAZOLOPYRIDAZINE SULFANYL BENZOTHIAZOLE DERIVATIVES AS MET INHIBITORS - The disclosure relates to compounds of formula (I): | 12-03-2015 |