Class / Patent application number | Description | Number of patent applications / Date published |
540203000 | Polycyclo ring system containing the hetero ring as one of the cyclos | 70 |
20100305315 | Process for the preparation of 2-(primary/secondary amino)hydrocarbyl)-carbamoyl-7-oxo-2,6-diaza-bicyclo [3.2.0.]heptane-6-sulfonic acid derivatives - A process for the production of a compound of formula (I) wherein | 12-02-2010 |
20110178291 | Process for the manufacture of bridged monobactam intermediates - A process for manufacturing a compound of Formula (I) which has cis-conformation and wherein R1 represents a 1-phenyl-C | 07-21-2011 |
540205000 | The ring nitrogen is shared by a six-membered ring | 32 |
540214000 | The six-membered ring contains sulfur | 32 |
540215000 | 1-thia-5-aza-bicyclo(4.2.0)octane (including unsaturated; e.g., cepham, etc.) | 32 |
20110040086 | Novel Beta-Lactam Antibiotics, Methods for Their Production, and Their Use - The invention relates to novel antimicrobial agents that are based on β-lactam derivatives and are produced by reacting previously known β-lactam derivatives with polyphenol oxidase substrates under the influence of free radicals and by forming salts of any β-lactam derivatives with polyhexamethylene biguanide hydrogen carbonate. Said novel compounds are suitable as an antibiotic. | 02-17-2011 |
540219000 | 7-amino cephalosporanic acid per se or salt thereof (i.e., 7-ACA or salt thereof) | 1 |
20100261897 | Improved Process For the Preparation of Cephalosporin Antibiotic Intermediate - The present invention relates to a process for the production of cephalosporin antibiotic intermediate of formula (I). More particularly relates to the preparation of the compound of formula (I) using a solvent medium selected from the group consisting of decalin (decahydronapthalene), hexane, cyclohexene, tetralin, petroleum ether, wherein X represents HI, HCI, H2SO4 and the like. The compound of formula (I) is an important intermediate in the preparation of Cefepime. | 10-14-2010 |
540220000 | Purification or recovery | 3 |
20080287673 | CEFDINIR PROCESS - The present invention provides an improved process for the preparation of high assayed cefdinir. Thus, crude cefdinir is added to water at 25-30° C. and then 18% hydrochloric acid is slowly added to form a clear solution. The solution is cooled to −5° C. and stirred for 5 minutes at −5° C. to +5° C. Then temperature of the mass is raised to 35-38° C., stirred for 15 minutes at the same temperature. To the reaction mass eno carbon is added at 35-38° C. and stirred for 30 minutes at 35-38° C. Then the contents are filtered on hiflo bed and washed with water. The filtrate is then cooled to 25° C., the pH is slowly adjusted to 2.6 with saturated sodium bicarbonate solution and stirred for 60 minutes at 25-30° C. Filtered the solid, washed with water and dried at 40° C. under vacuum to give high assayed cefdinir. | 11-20-2008 |
20110137026 | Crystalline (6r,7r)-7--3- [(R)-1'-Tert-Butoxycarbonyl-2-Oxo-[1,3']Bipyrrolidinyl-(3e)-Ylidenemethyl- ]-8-Oxo-5-Thia-1-Aza-Bicyclo[4.2.0] Oct-2-Ene-2-Carboxylic Acid Benzhydryl Ester; Its Manufacture and Use - A solid DMSO solvate of a compound of formula (I) is described, which is a useful intermediate for preparing the broad spectrum antibiotics Ceftobiprole and Ceftobiprole Medocaril. | 06-09-2011 |
20140005381 | NOVEL PROCESS FOR REFINING CEFMETAZOLE SODIUM | 01-02-2014 |
540221000 | 7,7-disubstituted | 1 |
20080306256 | Salts in the Preparation of Cephalosporin Antibiodies - The present invention relates to an improved process for the preparation of cephalosporin antibiotics of formula (I). The present invention also provides new salts of compound of formula (II) and a process for the preparation of these new salts, where n=0.5 to 2. The present invention also provides a process for the preparation of compound of formula (I) using the new salts of formula (II). | 12-11-2008 |
540222000 | Additional hetero ring containing | 23 |
20080242858 | Process For the Preparation of Cefixime - There is provided an improved process for preparing cefixime. Thus, for example, 7-amino-3-vinyl-3-cephem-4-carboxylic acid is reacted with 2-mercapto-1,3-benzothiazolyl-(Z)-2-(2-aminothiazol-4-yl)-2-(methoxycarbonyl)-methoxyimino acetate in tetrahydrofuran and water at 4° C. in the presence of triethylamine. The reaction mass is extracted with ethyl acetate. 7-[2-(2-Amino-4-thiazolyl)-2-(methoxycarbonylmethoxyimino)acetamido]-3-vinyl-3-cephem-4-carboxylic acid triethylamine salt present in the aqueous layer is hydrolyzed with sodium hydroxide in less than 30 minutes and aqueous hydrochloric acid is added immediately to adjust the pH to 4.8 to 5.2. Then, aqueous hydrochloric acid is added at 35° C. to adjust the pH 2.5 and cooled to crystallize cefixime trihydrate in high purity. | 10-02-2008 |
20080262219 | NOVEL CRYSTAL OF 7-[2-[(2-AMINOTHIAZOL-4-YL)-2-HYDROXYIMINOACETAMIDE-3-VINYL-3-CEPHEM-4-CARBOXYLIC ACID (SYN ISOMER) AND METHOD FOR PREPARATION THEREOF - A novel crystal (B-type crystal) of 7-[2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamide-3-vinyl-3-cephem-4-carboxylic acid (a syn isomer) , characterized in that it exhibits peaks at diffraction angles shown in the following Table 1, in its powder X ray diffraction pattern: | 10-23-2008 |
20090036672 | INTERMEDIATE CEFDINIR SALTS - Disclosed are salts of the general formula (I) | 02-05-2009 |
20090192306 | Cephalosporin in Crystalline Form - The present invention relates to cephalosporin of formula (I) in crystalline form. The compound of formula (I) in crystalline form is useful as antibiotics having potent and broad antibacterial activity; especially against methicillin resistant Staphylococci (MRSA) and | 07-30-2009 |
20120108807 | METHOD FOR THE PRODUCTION OF CEFTOBIPROLE MEDOCARIL - The present invention relates to a method for the production of organic compounds, in particular sodium (6R,7R)-7-[(Z)-2-(5-amino-[1,2,4]thiadiazol-3-yl)-2-hydroxyimino-acetylamino]-8-oxo-3-[(E)-(R)-1′-(5-methyl-2-oxo-[1,3]-dioxol-4-ylmethoxycarbonyl)-2-oxo-[1,3′]bipyrrolidinyl-3-ylidenemethyl]-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate (ceftobiprole medocaril), and compounds of the general formula (1) and of the general formula (2), the compounds themselves and intermediates in the production according to the invention. | 05-03-2012 |
20120116070 | METHOD FOR THE PRODUCTION OF CEFTOBIPROLE MEDOCARIL - The present invention relates to a method for the production of organic compounds, in particular sodium (6R,7R)-7-[(Z)-2-(5-amino-[1,2,4]thiadiazol-3-yl)-2-hydroxyimino-acetylamino]-8-oxo-3-[(E)-(R)-1′-(5-methyl-2-oxo-[1,3]-dioxol-4-ylmethoxycarbonyl)-2-oxo-[1,3′]bipyrrolidinyl-3-ylidenemethyl]-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate (ceftobiprole medocaril), and compounds of the general formula (1) and of the general formula (2), the compounds themselves and intermediates in the production according to the invention. | 05-10-2012 |
20130066065 | OXIDATION PROCESS FOR PREPARING 3-FORMYL-CEPHEM DERIVATIVES - The present invention relates to an improved process for oxidizing 3-hydroxy-methyl-cephem derivatives to the corresponding 3-formyl-cephem derivatives. In particular this oxidation process is for the preparation of 7-[2-(5-amino-[1,2,4]thia-diazol-3-yl)-2-hydroxyimino-acetylamino]-3-formyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid derivatives of formula (I) using a combination of a hypervalent iodine oxidizing agent of the type 10-I-3 such as bis(acetoxy)iodo-benzene (BAIB) and a catalyst such as 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO). These compounds of formula (I) are intermediates in the synthesis of ceftobiprole. | 03-14-2013 |
540223000 | 2- or 4-position substituent contains hetero ring | 2 |
20140088302 | NOVEL CEPHEM COMPOUND HAVING CATECHOL OR PSEUDO-CATECHOL STRUCTURE - The present invention provides a novel compound which has a wide antimicrobial spectrum, and in particular exhibits potent antimicrobial activity against beta-lactamase producing Gram negative bacteria. Specifically, the present invention provides a compound of the formula (I): | 03-27-2014 |
20140114060 | CEPHEM COMPOUND HAVING PYRIDINIUM GROUP - The present invention provides a novel compound which has a broad antibacterial spectrum and particularly exhibits a high antibacterial activity on β-lactamase-producing gram-negative bacteria. Specifically provided are: a compound represented by formula (I) | 04-24-2014 |
540224000 | 3-position substituent contains a pyridine ring (e.g., quinoline, thienopyridine, lutidines, etc.) | 7 |
20100113768 | PROCESS FOR PREPARING CEFSULODIN SODIUM - The invention is directed to an improved process for preparing cefsulodin sodium. The process involves: (i) dissolving cefsulodin in a solvent comprising an organic solvent to provide a solution of cefsulodin, (ii) adding about 1 equivalent of a sodium salt of a base to the solution of cefsulodin to provide a solution of cefsulodin sodium, and (iii) separating the cefsulodin sodium from the solution of cefsulodin sodium. | 05-06-2010 |
540225000 | 7-position substituent contains hetero ring | 6 |
20090131655 | Cephem Compounds Having Broad Antibacterial Spectrum - A compound of the formula: | 05-21-2009 |
20130090470 | OPTICALLY-DETECTABLE ENZYME SUBSTRATES AND THEIR METHOD OF USE - The present invention relates to compounds that are substrates for an enzyme, and upon reaction with the enzyme provide a detectable response, such as an optically detectable response. In particular, the compounds have utility in detecting the presence of a β-lactamase in a sample. In addition to the compounds, methods are disclosed for analyzing a sample for the presence of a β-lactmase, for example, as an indicator of expression of a nucleic acid sequence including a sequence coding for a β-lactmase. Kits are disclosed that include the disclosed compounds and additional components, for example, cells, antibodies, a β-lactmase or instructions for using the components in an assay. | 04-11-2013 |
20130096299 | NOVEL CEPHEM DERIVATIVE - Provided is a cephem compound which has a wide antimicrobial spectrum, and in particular exhibit potent antimicrobial activity against beta-lactamase producing Gram negative bacteria, and pharmaceutical composition comprising the same. | 04-18-2013 |
20140350240 | PROCESS FOR PREPARING CEFTAROLINE SALTS OR HYDRATES THEREOF - The present invention relates to a process for the preparation of ceftaroline salts or hydrates thereof. | 11-27-2014 |
20160009745 | NOVEL PROCESS FOR PREPARING CEFTAROLINE FOSAMIL | 01-14-2016 |
20160046655 | NOVEL PROCESS FOR PREPARING CEFTAROLINE FOSAMIL - The present invention relates to a novel process for preparing ceftaroline fosamil as well as to intermediates of this process. | 02-18-2016 |
540226000 | 3-position substituent contains sulfur | 6 |
20130303754 | REFINING PROCESS OF CEFAMANDOLE SODIUM - It discloses a novel process for refining cefamandole nafate, comprising: 1) adsorbing cefamandole nafate with strongly acidic ion exchange resin, followed by eluting the resin and collecting the eluate, to provide a primary purified cefamandole acid after concentration under reduced pressure; 2) neutralizing the primary purified cefamandole acid with an aqueous solution of sodium hydroxide or an aqueous solution of basic salt of sodium, followed by adjusting the pH value and filtrating out the insoluble substances with heating, thereby providing a secondary purified aqueous solution of cefamandole nafate; and 3) adding ethanol in a volume ratio between ethanol and water of 4:6 into the aqueous solution, to allow recrystallization under controlling the temperature, to provide a tertiary purified cefamandole nafate. The refined cefamandole nafate product has a purity of no less than 99.5%, mostly no less than 99.6%, with significantly low content of heavy metals. | 11-14-2013 |
20140200342 | PROCESS FOR PREPARING 3'-THIOSUBSTITUTED CEPHALOSPORINS EMPLOYING A PENCILLIN G ACYLASE - The present invention relates to a process for the preparation of 3′-thiosubstituted cephalosporins by enzymatic condensation of a nucleus with a phenylglycine derivative. Furthermore the present invention relates to a crystalline form of a compound of general formula (1) wherein R | 07-17-2014 |
20150112057 | NOVEL CRYSTALLINE CEFOPERAZONE INTERMEDIATE - The present invention relates to a crystalline form of an intermediate for cefoperazone of formula (1) and to a process for the preparation thereof by enzymatic condensation of a 3′-thiosubstituted β-lactam nucleus with a phenylglycine derivative. | 04-23-2015 |
540227000 | 7-position substituent contains hetero ring | 3 |
20080200670 | METHOD FOR THE MANUFACTURE OF CEFTRIAXONE SODIUM - An improved process for preparation of ceftriaxone sodium of formula (II), | 08-21-2008 |
20090299056 | Cefazolin Sodium Pentahydrate Crystal and Its Molecular Assembly Preparation Method - The present invention relates to cefazolin sodium pentahydrate crystal and a method for assembly and preparation of the crystal molecule. The cefazolin sodium pentahydrate crystal molecule contains five water molecules, orthorhombic system, space group of C | 12-03-2009 |
20140011994 | NOVEL PROCESS FOR PURIFYING CEFOTIAM HYDROCHLORIDE - A method for treating cefotiam hydrochloride, comprises the following steps: step 1), dissolving the raw material cefotiam hydrochloride in water, treating it with an acidic salt, then cooling it, and filtering the precipitate to obtain an aqueous filtrate; step 2), adding a water-immiscible solvent to the above aqueous solution for extraction, and then separating the organic phase containing impurities to obtain an aqueous solution containing cefotiam hydrochloride; step 3) adding to the aqueous solution a poor solvent of cefotiam hydrochloride and controlling the temperature for recrystallization, washing the educed crystals by centrifugation, and drying them to obtain purified cefotiam hydrochloride. The cefotiam content of the refined cefotiam hydrochloride obtained by the method of the present invention is not less than 86%, the content of polymeric impurities is less than 0.3%, and the content of insoluble microparticles in the injection prepared therefrom is quite low. | 01-09-2014 |
540228000 | Alkyl, hydroxyalkyl, alkoxyalkyl or alkanoyloxyalkyl bonded directly to 3 position | 1 |
20110257388 | CEFDINIR ACID DOUBLE SALT AND METHOD FOR PRODUCING THE SAME - A compound represented by Formula I, wherein M represents Na | 10-20-2011 |
540230000 | Alkyl, hydroxyalkyl, alkoxyalkyl or alkanoyloxyalkyl bonded directly to 3 position | 3 |
20080281093 | Novel Process For Preparation of Cefprozil Intermediate - The present invention relates to a process for preparing a key intermediate of cefprozil and use of this intermediate in the preparation of cefprozil thereby avoiding impurity-causing self-acylation. [R-(Z)]-[4-hydroxy-α-[(3-methoxy-1-methyl-3-oxo-1-propenyl)amino]]benzeneacetic acid, mono potassium salt is reacted with ethyl chloroformate to obtain mixed anhydride which is then silylated with N,O-bis(trimethylsilyl)acetamide. The silylated compound obtained is reacted with [7-trimethylsilylamino-3-(Z/E-propen-1-yl)-3-cephem-4-carboxylic acid]trimethylsilyl ester and deprotected with aqueous hydrochloric acid to give cefprozil. | 11-13-2008 |
20090221815 | PROCESSES FOR THE PREPARATION OF CEPHEM DERIVATIVES - Provided is a process for preparing a compound of formula 1 or its salt, which includes reacting a compound of formula 2 with a compound of formula 3 in the presence of a base. | 09-03-2009 |
20100010213 | PROCESS FOR THE CRYSTALLISATION OF CEFADROXIL - The present invention relates to a process for the preparation of cefadroxil in crystal form, comprising a) adding an aqueous solution of cefadroxil to a crystallisation vessel and a titrant to keep a pH in the crystallisation vessel of between 7 to 9; and b) lowering the pH in the crystallisation vessel to a value of between 5 and 6.5 to obtain a suspension of the β-lactam compound in crystal form. The invention further relates to cefadroxil in crystal form obtainable by the process according to the present invention. The invention also relates to cefadroxil in crystal form with a CIE b value of below 12 when stored at a temperature of 25° C. for at least 1 month. | 01-14-2010 |
540302000 | The ring nitrogen is shared by a five-membered ring | 36 |
20090118496 | Crystallization Method for Intermediates of Carbapenem Antibiotics - The present invention relates to an azetidinone compound extremely useful as a common intermediate for the synthesis of 1β-methylcarbapenem compounds. The present invention provides a crystallization method to obtain a crystal which has a higher quality and a higher stability than a conventional crystal and is excellent in filterability at the time of recovering crystal; an azetidinone compound having a low content of impurity; and an azetidinone compound which has a controlled particle size distribution of crystals and improved handleability and stability. The crystallization is carried out by adding a hydrocarbon solvent to a solution in which an azetidinone compound extremely useful as a common intermediate for the synthesis of 1β-methylcarbapenem compounds is dissolved in the presence of a seed crystal in an amount of 200% by weight or less based on the weight of the azetidinone compound. According to the method, the crystal having a high quality and a high stability and excellent filterability at the time of recovering the crystal can be obtained. | 05-07-2009 |
20090143574 | Carbapenem Compound - The present invention relates to a carbapenem compound represented by formula (Ia) shown below: | 06-04-2009 |
20100274003 | ACID ADDITION SALTS OF SYNTHETIC INTERMEDIATES FOR CARBAPENEM ANTIBIOTICS AND PROCESSES FOR PREPARING THE SAME - The present invention provides a process for preparing an acid addition salt of a synthetic intermediate for carbapenem antibiotics and a novel acid addition salt of a synthetic intermediate for carbapenem antibiotics obtained from the process. The present invention also provides a process for preparing a carbapenem antibiotic using the acid addition salt. According to the process of the present invention, an acid addition salt of a synthetic intermediate for carbapenem antibiotics can be prepared in a high yield and high purity, without conducting column chromatography. Thus, the process of the present invention can be applied to mass production with an industrial scale. Furthermore, since the acid addition salts have solid forms, they are easy to handle and keep in a manufacturing site. | 10-28-2010 |
20120296084 | Carbapenem Antibacterials with Gram-Negative Activity and Processes for Their Preparation - The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment. The present invention is also in the field of synthetic organic chemistry and is specifically provides an improved method of synthesis of β-methyl carbapenems which are useful as antibacterial agents. | 11-22-2012 |
20140148595 | METHOD FOR THE PREPARATION OF CARBAPENAM COMPOUNDS - The subject of the present invention is a method of the preparation of compounds containing the core skeleton of carbapenem antibiotics, novel intermediate compounds used in this method, a method of the preparation of the intermediate compounds as well as the use of the intermediate compounds in the production of carbapenem antibiotics. | 05-29-2014 |
540303000 | The five-membered ring contains an additional hetero atom | 8 |
20100010214 | LYOPHILIZED PREPARATION OF 1-METHYLCARBAPENEM - A lyophilized preparation comprising (1R,5S,6S)-6-[(1R)-1-hydroxyethyl]-1-methyl-2-[(2S,4S)-2-[(3S)-3-(2-guanidinoacetylamino)pyrrolidin-1-ylcarbonyl]-1-methylpyrrolidin-4-ylthio]-1-carbapen-2-em-3-carboxylic acid or a pharmacologically acceptable salt thereof as a carbapenem compound, which has a 1-alkylpyrrolidine structure and possesses a superior antimicrobial activity, and sodium chloride. | 01-14-2010 |
540304000 | 1-thia-4-aza-bicyclo(3.2.0)hep-tane (including unsaturated; e.g., penam, etc.) | 6 |
540309000 | Nitrogen containing hetero ring attached directly at the 3-position of the bicyclo ring system | 1 |
20100063273 | NOVEL CRYSTAL OF PIPERACILLIN SODIUM - Disclosed are a novel crystal of piperacillin sodium which has diffraction angles of 3.7°, 5.5°, 7.3°, 11.6°, 14.5° and 18.0° and a novel crystal of piperacillin sodium which has diffraction angles of 5.6°, 7.8°, 12.3°, 15.5°, 17.5°, 23.3°, 24.8° and 28.5° expressed by 2θ in the powder X-ray diffraction analysis. The crystals have excellent stability and solubility and a low water-absorbing property, is extremely easy to be handled in the manufacturing process for a medicinal substance and in the packing during the preparation process for a pharmaceutical product. A pharmaceutical preparation for injection comprising any one of the crystals is useful. | 03-11-2010 |
540310000 | Having -C(=X)-, wherein X is chalcogen, bonded directly at the 3-position of the bicyclo ring system | 5 |
20090012287 | Process for Producing Penam Compound - An object of the invention is to provide an industrially advantageous process capable of remarkably suppressing the generation of an undesirable by-product cepham compound to thereby efficiently produce a desired 2α-methyl-2β-[(1,2,3-triazol-1-yl)methyl]penam-3α-carboxylic acid ester. In the present invention, a diphenylmethyl 2β-bromomethyl-2α-methylpenam-3α-carboxylate (BMPB) is reacted with 1,2,3-triazole in a halogenated hydrocarbon solvent at −5° C. or lower. The reaction in a halogenated hydrocarbon solvent at −5° C. or less can remarkably suppress the generation of an undesirable by-product cepham compound, so that the desired diphenylmethyl 2α-methyl-2β-[(1,2,3-triazol-1-yl)methyl]penam-3α-carboxylate (TMPB) can be efficiently produced. | 01-08-2009 |
20090023915 | Process for the Preparation of Faropenem - The present invention is related to processes for the preparation of faropenem. | 01-22-2009 |
20090264642 | Anhydrous crystal of bata-lactam compound and method for preparation thereof - The present invention provides anhydrous crystals of β-lactam compound represented by the formula: | 10-22-2009 |
20090275746 | SOLID FAROPENEM FREE ACID - The present invention provides solid form of faropenem free acid, its hydrates and processes for their preparation thereof. Thus, for example, dissolving an alkali metal salt of faropenem in water, adjusting the pH of the solution formed with an acid to below about 2.5 and collecting the precipitated solid to obtain solid faropenem free acid. | 11-05-2009 |
20100113769 | METHOD FOR PRODUCING 6-HYDROXYETHYLPENAM COMPOUND - The present invention provides a method by which a 6-hydroxyethyl penam compound represented by General Formula (2) below can be produced with a high selectivity: | 05-06-2010 |
540347000 | Bicyclo ring system which is 1-oxa-4-aza-bicyclo(3.2.0)hep-tane (including unsaturated) | 1 |
540348000 | Acyclic carbon double bonded directly at the 2-position of the bicyclo ring system | 1 |
540349000 | Chalcogen attached directly by a single bond to the carbon or to an acyclic carbon chain which contains the carbon | 1 |
20110028712 | DIAMINE SALTS OF CARBOXYLIC ACIDS - The present invention relates to a salt of a carboxylic acid with a diamine such as 2,2′-(ethylenedioxy)diethyl amine, 3,3′-(ethylenedioxy)dipropyl amine and 2,2′-oxybis(ethylamine) and a method of preparing such salts. Preferably the carboxylic acid is a fermentation product such as clavulanic acid, mycophenolic acid or pravastatin. | 02-03-2011 |
540350000 | The ring system is 4-aza-bicyclo(3.2.0)heptane (including unsaturated) and has sulfur bonded directly at the 2-position | 23 |
20090216010 | CRYSTALLINE CARBAPENEM COMPOUND AND PRODUCED METHOD THEREOF - The present invention relates to a crystalline carbapenem compound and produced method thereof. The crystalline carbapenem compound of the present invention is crystalline (4R,5S,6S)-3-[[(3S,5S)-5-[(dimethylamino)carbonyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid and it is characterized by an X-ray powder diffraction pattern of FIG. | 08-27-2009 |
20090264643 | Process for The Preparation of Beta-Lactam Antibiotic - The present invention relates to a process for the preparation of Meropenem of formula (I) in sterile form and also provides an improved process for the preparation of compound of formula (V), which is an important intermediate in the synthesis of Meropenem. | 10-22-2009 |
20090299057 | MEROPENEM INTERMEDIATE IN NOVEL CRYSTALLINE FORM AND A METHOD OF MANUFACTURE OF MEROPENEM - The present invention specially relates to the crystalline form of (4-Nitrobenzyl (4R,5S,6S)-(3-{(3S,5S)-5-[(dimethylamino)carbonyl]-1-[(4-nitrophenoxy)carbonxyl]pyrrolidin-3-yl}thio-6-[(1R)-1-hydorxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0].hept-2-ene-2-carboxylate) of compound Formula I as well as an improved process for preparation of meropenem trihydrate of compound Formula II | 12-03-2009 |
20090312539 | AN IMPROVED PROCESS FOR THE PREPARATION OF CARBAPENEM ANTIBIOTIC - The present invention provides a process for the preparation of the carbapenem antibiotic of formula (I) or its salt in amorphous form. Formula (I) wherein R represents hydrogen or COOM and M represents hydrogen or sodium. | 12-17-2009 |
20100240886 | PROCESS FOR PRODUCING CARBAPENEM COMPOUND - The present invention has its object to provide an easy process for producing (4R,5S,6S)-3-[[(3S,5S)-5-(dimethylaminocarbonyl)-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, excellent in antimicrobial activity. The present invention relates to a process for continuously producing (4R,5S,6S)-3-[[(3S,5S)-5-(dimethylaminocarbonyl)-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid without isolating/purifying the reaction intermediate. | 09-23-2010 |
20100286389 | STABLE CRYSTAL OF BETA-LACTAM COMPOUND - A stable crystal (Form I crystal) of (4R,5S,6S)-6-[(1R)-1-hydroxyethyl]-4-methyl-3-({4-[(5S)-5-methyl-2,5-dihydro-1H-pyrrol-3-yl]-1,3-thiazol-2-yl}thio)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid which has preferable properties and a process for preparation Form I crystal which is characterized of desolvating a solvated crystal of its compound. | 11-11-2010 |
20100292463 | PROCESS FOR PRODUCTION OF B-LACTAM COMPOUND - Disclosed is a process for producing a carbapenem compound represented by Formula [1], which is characterized by allowing a base and a Lewis acid metal salt to coexist in the reaction of a compound represented by Formula [2] with a compound represented by Formula [3]. According to the process, a side-chain mercaptothiazole can be introduced into a β-lactam skeleton efficiently in the production of a β-lactam compound having an excellent antibacterial activity against a Gram-positive bacterium. [3] [2] [1] wherein R | 11-18-2010 |
20110082293 | PROCESS FOR THE PREPARATION OF STERILE DORIPENEM - The present invention relates to a process for the preparation of sterile doripenem. | 04-07-2011 |
20110224425 | PROCESS FOR PRODUCING CARBAPENEM DERIVATIVE AND INTERMEDIATE CRYSTAL THEREFOR - An object of the present invention is to provide a carbapenem synthetic intermediate which is advantageous in an industrial process. There are provided a process for producing Compound (I), or a pharmaceutically acceptable salt, or a solvate, or a crystal thereof, comprising reacting Compound (III) and Compound (IV) in the presence of the secondary amine, and a benzyl alcoholated crystal of Compound (I). There are further provided a method of deprotecting Compound (I) with a Pd catalyst, and a crystal of Compound (IV). | 09-15-2011 |
20110224426 | PROCESS FOR THE PREPARATION OF CARBAPENEM COMPOUNDS - The present invention relates to a process for the preparation of carbapenem compound of Formula (I), wherein P | 09-15-2011 |
20110288289 | Preparation of Carbapenem Intermediate and Their Use - The present invention relates to preparing carbapenem intermediates that are useful to produce Ertapenem, Meropenem and Doripenem. | 11-24-2011 |
20110288290 | PROCESS FOR THE PREPARATION OF CARBAPENEM USING CABAPENEM INTERMEDIATES AND RECOVERY OF CABAPENEM - The present invention relates to preparing carbapenem intermediates that are useful to produce Ertapenem, Meropenem and Doripenem; and provides an effective process for recovering ertapenem compounds. | 11-24-2011 |
20120035357 | PROCESS FOR THE PREPARATION OF CARBAPENEM ANTIBIOTIC - The present invention relates to an improved process for the preparation of the carbapenem antibiotic of formula (I) or its salts, hydrates and esters. The present invention further provides novel crystalline form of compound of general formula (III), wherein R | 02-09-2012 |
20120065392 | METHOD FOR PREPARING MEROPENEM USING ZINC POWDER - The present invention relates to an improved method for synthesizing meropenem trihydrate [(1R,5S,6S)-2-[((2′S,4′S)-2′-dimethylaminocarbozyl)pyrrolidin-4′-ylthio]-6-[(R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylic acid, trihydrate], which is a novel carbapenem antibiotic. | 03-15-2012 |
20120095209 | INTERMEDIATE OF ERTAPENEM, A COMPOSITION COMPRISING THE SAME AND PREPARATION METHODS THEREOF - Intermediates of Ertapenem of formula 2a wherein Np represents (I) or (II), and P | 04-19-2012 |
20120095210 | PROCESS FOR THE PREPARATION OF BETA-LACTAM ANTIBIOTIC - The present invention provides a novel process for the preparation of the meropenem trihydrate of formula (I). | 04-19-2012 |
20120190842 | PROCESS FOR THE PREPARATION OF ANTIBIOTIC COMPOUNDS - The present invention relates to a process for the preparation of carbapenem antibiotic compounds, which is useful for intravenous and intramuscular administration. | 07-26-2012 |
20130066066 | Method for Late Introduction of the (8R)-Hydroxyl Group Carbapenem Beta-Lactam Antibiotic Synthesis - The presently disclosed subject matter demonstrates that ThnG and ThnQ enzymes encoded by the thienamycin gene cluster in | 03-14-2013 |
20130253184 | PROCESS FOR THE PREPARATION OF PURE MEROPENEM TRIHYDRATE - The present invention relates to a process for the preparation of pure meropenem trihydrate. | 09-26-2013 |
20150038700 | DORIPENEM INTERMEDIATE COMPOUND, PREPARATION PROCESS THEREFOR AND USE THEREOF, AND PREPARATION PROCESS FOR DORIPENEM - The present invention provides a doripenem intermediate compound shown by formula (XIV), wherein PNB is p-nitrobenzyl, and HX is an acid; and when HX is a monobasic acid, n=1; and when HX is a polybasic acid, n=2. The present invention also provides a process for preparing the doripenem intermediate compound (XIV). In addition, the present invention provides a process for preparing doripenem (I) from the doripenem intermediate compound (XIV) in a simple manner, with a high yield and low production costs. The new mono-protected doripenem intermediate compound provided in the present invention contains only one protecting group, reducing the difficulty and complexity in the subsequent de-protection step by catalytic hydrogenation, increasing the yield of the catalytic hydrogenation reaction, and thus reducing the production cost of the final product. The process is easy to operate and suitable for industrialized production. | 02-05-2015 |
20150291591 | PROCESS FOR THE PREPARATION OF POLYMORPHS OF DORIPENEM - The present invention relates to a process for the preparation of polymorphs of doripenem. | 10-15-2015 |
20150353554 | PROCESS FOR PREPARING MEROPENEM TRIHYDRATE - Provided is a process for the preparation of meropenem trihydrate in high purity and high yield, including using a dry methanol solvate of meropenem, which can remarkably reduce the amount of residual solvents in the resulting product, thereby obtain meropenem trihydrate in high purity. | 12-10-2015 |
540351000 | Thienamycin per se or salt thereof | 1 |
20160083760 | METHOD FOR LATE INTRODUCTION OF THE (8R) HYDROXYL GROUP CARBAPENEM BETA-LACTAM ANTIBIOTIC SYNTHESIS - The presently disclosed subject matter demonstrates that ThnG and ThnQ enzymes encoded by the thienamycin gene cluster in | 03-24-2016 |