Entries |
Document | Title | Date |
20080281041 | Reversibly Masked Polymers - The present invention is directed to reversibly inactivation of membrane active polymers useful for cellular delivery of compounds. Described are polyconjugates systems that incorporate targeting, anti-opsonization, anti-aggregation, and transfection activities into small biocompatible in vivo delivery conjugates. The use of multiple reversible linkages connecting component parts provides for physiologically responsive activity modulation. | 11-13-2008 |
20080306212 | POLYMER CONJUGATES OF MUTATED NEUBLASTIN - A dimer comprising a mutated neublastin polypeptide coupled to a polymer is disclosed. Such dimers exhibit prolonged bioavailability and, in preferred embodiments, prolonged biological activity relative to wild-type forms of neublastin. | 12-11-2008 |
20090023859 | POLYOXYALKYLENE DERIVATIVE - A novel polyoxyalkylene derivative represented by the following formula (1), wherein each symbol is as defined in the specification, which has a functional group capable of reacting with various physiologically active substances according to the object is provided. | 01-22-2009 |
20090054590 | Multi-armed, monofunctional, and hydrolytically stable derivatives of poly (ethylene glycol) and related polymers for modification of surfaces and molecules - Multi-armed, monofunctional, and hydrolytically stable polymers are described having the structure | 02-26-2009 |
20090131587 | Solid Support for Fmoc-Solid Phase Synthesis of Peptides - The present invention provides compositions and processes for the solid phase synthesis of polypeptides. In particular, the present invention provides solid supports and processes for preparing solid supports for the synthesis of polypeptides. | 05-21-2009 |
20090137736 | Accelerants for the Modification of Non-Natural Amino Acids and Non-Natural Amino Acid Polypeptides - Disclosed herein are accelerants for the formation of oxime-containing compounds from the reaction of a carbonyl-containing compound and a hydroxylamine-containing compound. The oxime-containing compound, the carbonyl-containing compound and the hydroxylamine-containing compound can each be a non-natural amino acid or a non-natural amino acid polypeptide. Also disclosed is the use of such accelerants to form oxime-containing compounds, the resulting oxime-containing compounds, and reaction mixtures containing such accelerants. | 05-28-2009 |
20090137737 | Organic compounds - The invention relates to novel crosslinkable copolymers of formula | 05-28-2009 |
20090186984 | Poly(Ethylene Glycol) Derivatives with Proximal Reactive Groups - An activated, substantially water-soluble poly(ethylene glycol) is provided having of a linear or branched poly(ethylene glycol) backbone and at least one terminus linked to the backbone through a hydrolytically stable linkage, wherein the terminus is branched and has proximal reactive groups. The free reactive groups are capable of reacting with active moieties in a biologically active agent such as a protein or peptide thus forming conjugates between the activated (polyethylene glycol) and the biologically active agent. | 07-23-2009 |
20090203842 | Macromolecular Conjugates And Processes For Preparing The Same - Making a suspended or soluble macromolecular conjugate comprising binding a first macromolecule to a solid via a stable, disruptable bond, stably linking additional macromolecules, and releasing the macromolecular conjugate, as well as macromolecular conjugates prepared by the method. | 08-13-2009 |
20090234070 | Water-Soluble Polymer Alkanals - The present invention is directed to alkanal derivatives of water-soluble polymers such as poly(ethylene glycol), their corresponding hydrates and acetals, and to methods for preparing and using such polymer alkanals. The polymer alkanals of the invention are prepared in high purity and exhibit storage stability. | 09-17-2009 |
20090253864 | IL-21 Derivatives and Variants - The invention provides derivatives of IL-21 or variants thereof, methods of producing such variants, new variants of IL-21, and various methods of using such molecules. | 10-08-2009 |
20090306290 | Biocompatible, Biodegradable, Water-Absorbent Hybrid Material - A biocompatible, biodegradable, macromolecular water-absorbent hybrid material (WAHM), having a three-dimensional configuration with intermolecular covalent bonds and containing free functional groups, said polymer being formed by polymer-polymer intercoupling reaction between a natural water-soluble polymer A or its derivatives having a molecular weight between 20,000 and 300,000 Da, and a synthetic polymer B in an adequate ratio wherein the natural polymer A is selected from amphoteric reactants, partially denatured or chemically modified natural polymer, that dissociates in water to form both anions and cations, and which can undergo polymer-polymer intercoupling reactions, and wherein synthetic polymer B s a linear or branched reactive synthetic copolymer having a molecular weight of 50,000-500,000 Da derived from a vinyl monomer and an ethylenically unsaturated monomer, having a backbone with polymeric subunits covalently bonded to the polymer backbone, the subunits comprising ones with non-reactive and others with reactive chemical functional groups. | 12-10-2009 |
20100004390 | BIODEGRADABLE METAL-CHELATING POLYMERS AND VACCINES - The invention provides metal-chelating poly(ether amide) polymers useful in preparation of polymer compositions for delivering a variety of cargo molecules, such as bioactive agents. In solution metal ions and cargo molecules, such as vaccine epitopes, that include metal avid amino acids can be loaded into the polymer compositions and held in a non-covalent complex. Nanoparticles of such polymer compositions can also be prepared directly from the solution. | 01-07-2010 |
20100004391 | METHOD FOR DERIVATIZING HAIR WITH A REACTIVE POLYETHYLENE GLYCOL - A method of protecting hair by covalently bonding to the hair a polymeric compound comprising polyethylene glycol. | 01-07-2010 |
20100004392 | Hydrolytically Degradable Polymers and Hydrogels Made Therefrom - A water soluble polymer comprising multiple degradable carbonate linkages in a backbone and, for each carbonate linkage in the backbone, an oligomer linked thereto by the carbonate linkage, wherein the oligomer is branched. | 01-07-2010 |
20100010158 | Segmented Degradable Polymers and Conjugates Made Therefrom - The present invention provides, among other things, segmented, degradable polymeric reagents suitable for reaction with biologically active agents to form conjugates, the polymeric reagents comprising one or more polymer chains divided or separated by one or more degradable linkages into polymer segments having a molecular weight suitable for renal clearance. The polymeric reagents can have a substantially linear structure, a branched structure, or a multiarm structure. Each structure includes one or more linkages capable of degradation in vivo. | 01-14-2010 |
20100016506 | PROTEIN STABILIZING AGENT - A method for stabilizing a protein by adding a copolymer to a composition containing the protein where the copolymer has: a repeating unit (A) represented by the following formula (1) and a repeating unit (B) represented by the following formula (2): | 01-21-2010 |
20100056720 | SELF-ASSEMBLING METHOD AND STRUCTURE - Disclosed are compositions and methods for self-assembling polymeric particles by using biological binders attached to subunits of a multi-sectioned polymeric particle. | 03-04-2010 |
20100069571 | Thioester-Terminated Water Soluble Polymers and Method of Modifying the N-Terminus of a Polypeptide Therewith - The invention provides reagents and methods for conjugating a polymer specifically to the α-amine of a polypeptide. The invention provides monofunctional, bifunctional, and multifunctional PEGs and related polymers having a terminal thioester moiety capable of specifically conjugating to the α-amine of a polypeptide having a cysteine or histidine residue at the N-terminus. The invention provides reactive thioester-terminated PEG polymers that have suitable reactivity with an N-terminal cysteine or histidine residue of a polypeptide to produce an amide bond between the PEG molecule and the polypeptide. | 03-18-2010 |
20100081766 | RESIN COMPOSITION AND RESIN MOLDED PRODUCT - A resin composition includes a polyester capable of forming a crystal structure, and a substance represented by the following general structural formula (1), the substance represented by the following general structural formula (1) has a dehydration-condensed structure of two molecules of natural product-derived α-amino acids or a substitution structure thereof, and the two molecules of α-amino acids are not simultaneously glycine. | 04-01-2010 |
20100093933 | Substituted Guar Protein Extracts and Production/Applications Thereof - A variety of products are obtained from modified guar protein extracts, for example, cosmetic or pharmacological or plant protective compositions or domestic care agents containing such products; these are particularly suitable for treating and/or modifying and/or coating the skin, hair, hard and textile surfaces and, notably, plant leaf surfaces. | 04-15-2010 |
20100093934 | PEGYLATION OF RECOMBINANT BLOOD COAGULATION FACTORS IN THE PRESENCE OF BOUND ANTIBODIES - The present invention relates to a proteinaceous construct comprising a blood coagulation factor, e.g., Factor VIII (FVIII), being bound to at least one water soluble polymer, including a poly(alkylene oxide) such as polyethylene glycol (PEG). Further the present invention relates to methods of preparing PEGylated blood coagulation factor, e.g., FVIII, in the presence of bound antibodies. The invention also relates to methods for prolonging the in vivo-half-life of blood coagulation factor, e.g., FVIII, in the blood of a mammal having a bleeding disorder associated with functional defects or deficiencies of blood coagulation factor, e.g., FVIII. | 04-15-2010 |
20100120982 | POLYMER-FACTOR IX MOIETY CONJUGATES - Conjugates of a Factor IX moiety and one or more water-soluble polymers are provided. Typically, the water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided (among other things) are compositions comprising the conjugates, methods of making the conjugates, and methods of administering to a patient compositions comprising the conjugates. | 05-13-2010 |
20100130684 | POLYMER FACTOR IX MOIETY CONJUGATES - Conjugates of a Factor IX moiety and one or more water-soluble polymers are provided. Typically, the water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided (among other things) are compositions comprising the conjugates, methods of making the conjugates, and methods of administering to a patient compositions comprising the conjugates. | 05-27-2010 |
20100137510 | COMPOSITIONS AND METHODS FOR SCAFFOLD FORMATION - The present invention relates to scaffolds composed of a protein backbone cross-linked by a synthetic polymer. Specifically, the present invention provides PEGylated-thiolated collagen scaffolds and PEGylated albumin scaffolds and methods of generating and using same for treating disorders requiring tissue engineering. | 06-03-2010 |
20100137511 | POLYMER FACTOR IX MOIETY CONJUGATES - Conjugates of a Factor IX moiety and one or more water-soluble polymers are provided. Typically, the water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided (among other things) are compositions comprising the conjugates, methods of making the conjugates, and methods of administering to a patient compositions comprising the conjugates. | 06-03-2010 |
20100137512 | Polyethylene glycol/polycation block copolymers - The invention provides block copolymers formed of poly(ethylene glycol) segments and poly(amino acid derivative) segments having side chains of at least one kind of specific amine residue. The invention also provides polyion complexes of such copolymers with polynucleotides and the like. These block copolymers are useful as carriers for in vivo delivery of active substances such as DNA. | 06-03-2010 |
20100160556 | GLP-1 Fusion Peptides Conjugated to Polymer(s), Their Production and Use - The present invention provides fusion peptides having GLP-1 activity and enhanced stability in vivo, in particular resistancy to dipeptidyl peptidase IV conjugated to polymers, thereby forming conjugate molecules. The fusion peptide of the conjugate molecule comprises as component (I) N-terminally a GLP-1(7-35, 7-36 or 7-37) sequence and as component (II) C-terminally a peptide sequence of at least 9 amino acids or a functional fragment, variant or derivative thereof. A synthetic polymer and/or a protein, e.g transferrin or albumin, is covalently or non-covalently bound to the fusion peptide to form the conjugate molecule. Component (II) is preferably a full or partial version of IP2 (intervening peptide 2). A preferred embodiment comprises the sequence GLP-1(7-35, 36 or 37)/IP2/GLP-1(7-35, 36 or 37) or GLP-2 and a polymeric component, e.g. a natural or non-natural polymer. The fusion peptide may be produced in engineered cells or synthetically and is e.g. conjugated to the polymeric component by chemical synthesis. The conjugate molecule may be used for the preparation of a medicament for treating various diseases or disorders, e.g. diabetes type 1 or 2, apoptosis related diseases or neurodegenerative disorders. | 06-24-2010 |
20100190927 | MHC OLIGOMERS, COMPONENTS THEREOF, AND METHODS OF MAKING THE SAME - The present invention relates to an MHC binding polymer suitable for the oligomerisation of individual MHC monomers. The MHC binding polymer comprises a first segment and a second segment, wherein the first segment comprises a peptide capable of binding in a binding groove of an MHC molecule, and wherein the second segment comprises a linking segment and a recognition site for coupling the MHC binding polymer with a specific partner. The linking segment is a polymer with a length of at least 10 Angstrom in its native conformation. Further it relates to an MHC oligomer containing such MHC binding polymers. Individual functional MHC complex monomers are oligomerised via their peptides bound in the peptide binding groove of the complex. Moreover, it relates to a method of making such MHC binding polymer and oligomer and various methods using the same. | 07-29-2010 |
20100222508 | MAGNETIC POLYMER PARTICLES - A conjugate comprising a magnetic polymer particle bound to a carboxymethylated aspartate chelating ligand, optionally chelating a metal ion. | 09-02-2010 |
20100261842 | Purified vegetarian protein A and process for production thereof - Purification of vegetarian (non-animal derived) Protein A using a multidimensional purification process to remove undesirable non-animal derived component impurities in the Protein A from the non-animal fermentation media used to produce the Protein A so as to produce a vegetarian Protein A free of animal-origin components and essentially free of components derived from non-animal derived growth media. | 10-14-2010 |
20100267895 | Hydrolytically Degradable Polymers and Hydrogels Made Therefrom - Conjugates between a protein and a water soluble polymer comprising multiple degradable carbonate linkages are provided. | 10-21-2010 |
20100273943 | PEPTIDE CONJUGATES AND FLUORESCENCE DETECTION METHODS FOR INTRACELLULAR CASPASE ASSAY - Polypeptides labelled with a donor and acceptor pair of dyes selected from a dibenzorhodamine dye and a diamino-benzophenoxazine dye are peptide conjugates which are useful for intracellular and bead-based assays with fluorescence detection. Peptide conjugates with a caspase-recognition site undergo cleavage into peptide fragments which may be detected, located, and quantitated by the changes in fluorescence. Intracellular cleavage of peptide conjugates is correlated with apoptosis. | 10-28-2010 |
20100280177 | MULTICOMPONENT ASSEMBLIES HAVING ENHANCED BINDING PROPERTIES FOR DIAGNOSIS AND THERAPY - An organized mobile multicomponent conjugate (OMMC) and method of using to enhance binding of weakly binding compounds to a target. A lamellar structure containing at least two binding compounds is assembled under conditions in which the binding compounds self-regulate in or on the lamellar structure, forming a cooperative ensemble that is capable of binding with enhanced affinity to a complementary affinity site on a target. Each binding compound is bound to the lamellar surface, and may be connected by a linker. The OMMC may contain an effector molecule, such as a diagnostic or therapeutic agent, for administration to a patent who is then diagnosed or treated using the effector molecule. | 11-04-2010 |
20100292402 | COMPOSITIONS THAT REVERSIBLY GEL AND DE-GEL - The present invention provides a composition comprising a first polymer and a second polymer cross-linked by the association of functional groups attached as side chains to the polymers. | 11-18-2010 |
20100298495 | BLOCK COPOLYMER FOR DRUG CONJUGATES AND PHARMACEUTICAL COMPOSITION - The present invention provides a block copolymer for a drug conjugate which comprises a water-soluble polymer region consisting of polyethylene glycol and a polyamino acid region having a hydrazide group and a hydrophobic group in the side chain. | 11-25-2010 |
20100298496 | MULTI-ARMED, MONOFUNCTIONAL, AND HYDROLYTICALLY STABLE DERIVATIVES OF POLY(ETHYLENE GLYCOL) AND RELATED POLYMERS FOR MODIFICATION OF SURFACES AND MOLECULES - Multi-armed, monofunctional, and hydrolytically stable polymers are described having the structure | 11-25-2010 |
20100311902 | NANOPARTICLES COMPRISING CALCIUM PHOSPHATE ETHYLENE IMINE COMPOSITIONS AND METHODS OF PRODUCTION THEREOF - Highly dispersible inorganic compound nanoparticles modified by functional molecules include the functional molecules; a high molecular nitrogen compound having at least two amino groups selected from primary amino groups, secondary amino groups and tertiary amino groups; and inorganic compound nanoparticles bonded to at least one amino group of the at least two amino groups. The high molecular nitrogen compound is modified by the functional molecules, and the inorganic compound nanoparticles are covered with the high molecular nitrogen compound modified by the functional molecules. | 12-09-2010 |
20100324215 | AFFINITY STRUCTURES FOR THE SPECIFIC BINDING OF SUBSTANCES BY MEANS OF NON-COVALENT INTERACTION TYPES - A method for producing affinity binders having affinitive or highly affinitive binding structures for non-covalent interaction types includes a) contacting a target substance with at least one ligand which is capable of non-covalently binding to the target substance for a sufficient time that the at least one ligand can specifically attach to target regions of the target substance and form a ligand-target substance complex; b) embedding the complex in a structure-providing component and fixing by binding the ligand(s) of the complex to the structure-providing component; and c) removing the target substance such that a structure with a defined spatial arrangement of the ligand(s) is formed which has capacity to specifically bind the respective target substance again. | 12-23-2010 |
20100331489 | BRANCHED WATER-SOLUBLE POLYMERS AND THEIR CONJUGATES - The present invention provides branched water-soluble polymers that allow two or more water-soluble polymers to be conjugated to another species. The branched polymers provide access to therapeutic agents that are conjugated at a single site to two or more water-soluble polymers. The branched polymers are based upon branch points that are simple branched alkyl structures, reactive side-chain amino acids and small peptides of reactive side-chain amino acids, and saccharides. Also provided is a method for preparing mono-disperse poly(ethylene glycol) of a well-defined and determinable molecular weight, and a method for the rational end-functionalization of poly(ethylene glycol). Conjugates of the branched water-soluble polymers with diverse species, e.g., peptides, lipids, glycolipids and small molecules are also provided. | 12-30-2010 |
20110015344 | BIODEGRADABLE POLYACETALS FOR IN VIVO POLYNUCLEOTIDE DELIVERY - Degradable complexes comprising a polycation, a polyanion and a polynucleotide are useful for in vivo polynucleotide delivery applications. | 01-20-2011 |
20110015345 | Modified FGF-23 Polypeptides and Their Uses - Modified FGF-23 polypeptides and uses thereof are provided. | 01-20-2011 |
20110065862 | Thioester-Terminated Water Soluble Polymers and Method of Modifying the N-Terminus of a Polypeptide Therewith - The invention provides reagents and methods for conjugating a polymer specifically to the α-amine of a polypeptide. The invention provides monofunctional, bifunctional, and multifunctional PEGs and related polymers having a terminal thioester moiety capable of specifically conjugating to the α-amine of a polypeptide having a cysteine or histidine residue at the N-terminus. The invention provides reactive thioester-terminated PEG polymers that have suitable reactivity with an N-terminal cysteine or histidine residue of a polypeptide to produce an amide bond between the PEG molecule and the polypeptide. | 03-17-2011 |
20110152455 | MONOMERS FOR MAKING POLYMERIC CELL CULTURE SURFACE - N-hydroxysuccinimide acrylate ester monomers are described which provide N-hydroxysuccinimide derivatized monomers for the formation of polymeric cell culture surfaces suitable for culture of difficult to culture cells including undifferentiated embryonic stem cells. Methods of making the monomers and are also described. | 06-23-2011 |
20110160398 | BIOCOMPATIBLE, BIODEGRADABLE, WATER-ABSORBENT HYBRID MATERIAL - A biocompatible, biodegradable, macromolecular water-absorbent hybrid material (WAHM), having a three-dimensional configuration with intermolecular covalent bonds and containing free functional groups, said polymer being formed by polymer-polymer intercoupling reaction between a natural water-soluble polymer A or its derivatives having a molecular weight between 20,000 and 300,000 Da, and a synthetic polymer B in an adequate ratio wherein the natural polymer A is selected from amphoteric reactants, partially denatured or chemically modified natural polymer, that dissociates in water to form both anions and cations, and which can undergo polymer-polymer intercoupling reactions, and wherein synthetic polymer B is a linear or branched reactive synthetic copolymer having a molecular weight of 50,000-500,000 Da derived from a vinyl monomer and an ethylenically unsaturated monomer, having a backbone with polymeric subunits covalently bonded to the polymer backbone, the subunits comprising ones with non-reactive and others with reactive chemical functional groups. | 06-30-2011 |
20110160399 | HISTONE MODIFICATION INHIBITOR SPECIFIC TO TARGET GENE - The present invention provides a target gene-specific histone modification regulator, which comprises a conjugate between a histone modification regulator and a polyamide capable of recognizing a regulatory region in a target gene. This enables the provision of a target gene-specific histone modification regulator. | 06-30-2011 |
20110178242 | Methods for Forming Polymer-Drug Conjugates - Methods for preparing polymer-drug conjugates are provided. The disclosed methods involve polymeric reagents comprising a moiety of atoms arranged in a specific order, wherein the moiety is positioned between a water-soluble polymer and a reactive group. Related methods, compositions, preparations, and so forth are also provided. | 07-21-2011 |
20110178243 | Process for Attaching a Modifying Agent to a Substrate - Modifying agents, e.g., a poly(sulfonyl) azide, are attached to a substrate surface, e.g., the surface of a polyolefin particle, by a process comprising the steps of: A. Contacting in an open contact zone and under a flow of inert gas a substrate with a modifying agent, binding agent, e.g., a phenolic-based antioxidant, and a liquid mixing agent, e.g., methylene chloride, to form a substrate mixture; B. Closing the contact zone and stopping the flow of inert gas to the contact zone; C. Agitating the substrate mixture under the inert gas in the closed contact zone to commence evaporation of the liquid mixing agent; D. Reducing the temperature and pressure of the closed contact zone while continuing to agitate the substrate mixture; and E. Completing the substantial evaporation of the mixing agent from the substrate mixture by opening the contact zone and initiating an inert gas flow while continuing agitation of the substrate mixture and maintaining a reduced pressure. | 07-21-2011 |
20110201754 | High-Molecular Weight Conjugate Of Physiologically Active Substances - Disclosed is a water-soluble high-molecular weight conjugate of physiologically active substances which enable medicament to release without depending on the enzymes in a living body and which is expected to have a useful therapeutic effect. A high-molecular weight conjugate of a physiologically active substance has a substituent group represented by a general formula (1) bonded to a side-chain carboxy group of a block copolymer which has a polyethylene glycol moiety and either a polyaspartic acid moiety or a polyglutamic acid moiety. Formula (1): —Ar—CR15R16-O—C(═O)-A [In the formula: Ar represents an aromatic hydrocarbon group optionally a substituent group, or an aromatic heterocyclic group optionally having a substituent group; R15 and R16 independently represent a hydrogen atom or a (C1-C6) alkyl group optionally having a substituent group; and A represents a residual group of a physiologically active substance that has an carboxy group, or a residual group of a physiologically active substance that has an amino group]. | 08-18-2011 |
20110213082 | INSULINOTROPIC PEPTIDE SYNTHESIS USING SOLID AND SOLUTION PHASE COMBINATION TECHNIQUES - The present invention relates to the preparation of insulinotropic peptides that are synthesized using a solid and solution phase (“hybrid”) approach. Generally, the approach includes synthesizing three different peptide intermediate fragments using solid phase chemistry. Solution phase chemistry is then used to add additional amino acid material to one of the fragments. The fragments are then coupled together in the solid solution phase. The use of a pseudoproline in one of the fragments eases solid phase synthesis of that fragment and also eases subsequent solution phase coupling of this fragment to other fragments. The present invention is very useful for forming insulinotropic peptides such as GLP-1(7-36) and its natural and non-natural counterparts. | 09-01-2011 |
20110230618 | Polymeric Alpha-Hydroxy Aldehyde and Ketone Reagents and Conjugation Method - Provided herein are polymeric α-hydroxy aldehyde or α-hydroxy ketone reagents which can be conjugated to amine-containing compounds to form stable conjugates in a single-step reaction. In selected embodiments, the polymeric reagent itself incorporates an internal proton-abstracting (basic) functional group, to promote more efficient reaction. The substituent is appropriately situated, via a linker if necessary, to position the group for proton abstraction, preferably providing a 4- or 5-bond spacing between the abstracting atom and the hydrogen atom on the α-carbon. Also provided are methods of using the reagents and stable, solubilized conjugates of the reagents with biologically active compounds. In preferred embodiments, the polymeric component of the reagent or conjugate is a polyethylene glycol. | 09-22-2011 |
20110237747 | Multi-Arm Polypeptide-Poly(ethylene glycol) Block Copolymers as Drug Delivery Vehicles - The invention provides a multi-arm block copolymer for use in delivering a variety of bioactive agents. The copolymer of the invention contains a central core from which extend multiple (3 or more) copolymer arms. Each copolymer arm possesses an inner polypeptide segment and an outer hydrophilic polymer segment. Thus, the overall structure of the copolymer comprises an inner core region that includes the central core and the inner polypeptide segment, while the outer core region is hydrophilic in nature. The multi-arm copolymer of the invention is particularly useful for delivery of biologically active agents that can be entrapped within the inner core region. | 09-29-2011 |
20110288234 | SILICA NANOPARTICLES POSTLOADED WITH PHOTOSENSITIZERS FOR DRUG DELIVERY IN PHOTODYNAMIC THERAPY - A nanoparticle including a polysiloxane base having an exterior surface and having a photosensitizer at least partly exposed at its exterior surface, said photosensitizer being secured to the exterior surface by loading the photosensitizer onto the surface after formation of the polysiloxane base of the nanoparticle. The nanoparticle may have tumor targeting moieties and may be post loaded with cyanine dye. The nanoparticle preferably includes post loaded moieties providing at least two of tumor specificity, photodynamic properties and imaging capabilities and the photosensitizer is tagged with a radioisotope. A method for preparation of the nanoparticle is also provided. | 11-24-2011 |
20110294952 | Optimized Drug Conjugates - The invention generally relates to optimized drug conjugates. | 12-01-2011 |
20120016082 | CONJUGATION REACTIONS - An initiator for the terminal group of the polymer product of an atom or group radical transfer polymerisation has an activated carboxyl or an amine group which is reacted with an amine or carboxyl (respectively) group containing biologically active compound. The initiator is preferably 4-(3-(2-bromo, 2-methyl-propionate)phenyl)-propionic acid N-hydroxysuccinimide ester or 2-bromo, 2-methyl-propionic acid N-hydroxysuccinimide ester. The monomers preferably comprise a zwitterionic monomer such as 2-methacryloxyethyl-2′-trimethyl ammoniumethyl phosphate inner salt. | 01-19-2012 |
20120029150 | CROSSLINKED FIBERS AND METHOD OF MAKING SAME BY EXTRUSION - The present disclosure relates to a method of forming fibers. First and second precursors, each possessing a core and at least one functional group known to have click reactivity, are mixed. The mixed precursors are then extruded under heat to cross-link during fiber production. | 02-02-2012 |
20120035320 | POLYACRIDINE NUCLEIC ACID DELIVERY PEPTIDE COMPLEXES - The present invention provides nucleic acid delivery polyplex complexes and anionic open polyplexes comprising a nucleic acid molecule reversibly bound to one or more of nucleic acid delivery polyplex complexes. | 02-09-2012 |
20120035321 | COMPOUNDS AND MEDICAL DEVICES ACTIVATED WITH SOLVOPHOBIC LINKERS - The present disclosure relates to compounds and medical devices activated with a solvophobic material functionalized with a first reactive member and methods of making such compounds and devices. | 02-09-2012 |
20120065330 | Thioester-Terminated Water Soluble Polymers and Method of Modifying the N-Terminus of a Polypeptide Therewith - The invention provides reagents and methods for conjugating a polymer specifically to the α-amine of a polypeptide. The invention provides monofunctional, bifunctional, and multifunctional PEGs and related polymers having a terminal thioester moiety capable of specifically conjugating to the α-amine of a polypeptide having a cysteine or histidine residue at the N-terminus. The invention provides reactive thioester-terminated PEG polymers that have suitable reactivity with an N-terminal cysteine or histidine residue of a polypeptide to produce an amide bond between the PEG molecule and the polypeptide. | 03-15-2012 |
20120095165 | AFFINITY MATERIAL - The present application relates to an affinity material useful in antibody purification. | 04-19-2012 |
20120095166 | SELF-ASSEMBLING MONOMERS AND OLIGOMERS AS SURFACE-MODIFYING ENDGROUPS FOR POLYMERS - Polymers having the formula R(LE) | 04-19-2012 |
20120108748 | SOLID PHASE PEPTIDE SYNTHESIS OF PEPTIDE ALCOHOLS - The present invention relates to the synthesis of depsipeptides on solid phase support. Said depsipeptides are then implicated in a solution phase O—N acyl shift enabling to obtain the corresponding peptide alcohols. | 05-03-2012 |
20120142861 | SOLUBILISATION OF MEMBRANE PROTEINS - A method is provided for solubilising a membrane protein. The method is applied to cellular material comprising the membrane protein and an associated membrane lipid. A copolymer of styrene and maleic acid, wherein the styrene:maleic acid ratio is between 1:2 and 10:1, is mixed with the cellular material to cause the copolymer, lipid and protein to form soluble macromolecular assemblies. | 06-07-2012 |
20120149843 | NANOFIBERS AND MORPHOLOGY SHIFTING MICELLES - The invention discloses novel morphology shifting micelles and amphiphilic coated metal nanofibers. Methods of using and making the same are also disclosed. | 06-14-2012 |
20120202948 | MONODISPERSE RANDOM COIL PROTEINS AND BIOCONJUGATES THEREOF - The present disclosure provides substantially monodisperse random coil polypeptides, vectors encoding the polypeptides, conjugates containing the polypeptides, methods for their preparation, and their uses in nucleic acid separations, DNA sequencing, and other applications requiring high monodispersity. | 08-09-2012 |
20120220720 | FUNCTIONALIZED CELL BINDING PEPTIDES AND CELL CULTURE ARTICLES - Synthetic surfaces capable of supporting culture of cells in culture, particularly cells that will be used therapeutically, are disclosed. The synthetic cell culture surfaces have a functionalized peptide, a peptide that has been functionalized to contain a polymerization moiety, and optionally a spacer, grafted to a hydrophilic polymeric base material. Methods of making the surfaces and methods of using the surfaces are also disclosed. | 08-30-2012 |
20120220721 | Method for Native Ligation of Polypeptides - The invention mainly relates to a method for manufacturing a polypeptide of formula: | 08-30-2012 |
20120245288 | METHODS OF MAKING AND USING SURFACTANT POLYMERS - Comblike, surfactant polymers for changing the surface properties of biomaterials are provided. Such surfactant polymers comprise a polymeric backbone of repeating monomeric units having functional groups for coupling with side chains, a plurality of hydrophobic side chains linked to the backbone via the functional groups, and a plurality of hydrophilic side chains linked to said backbone via the functional groups. Medical devices coated with the surfactant polymers are also provided. The surfactant polymers may be used to decrease the thrombogenic properties, encapsulation, and bacterial colonization of medical devices. | 09-27-2012 |
20120245289 | POLYMER-FACTOR VIII MOIETY CONJUGATES - Conjugates of a Factor VIII moiety and one or more water-soluble polymers are provided. Typically, the water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided are compositions comprising the conjugates, methods of making the conjugates, and methods of administering compositions comprising the conjugates to a patient. | 09-27-2012 |
20120271000 | COMPOSITIONS COMPRISING CONJUGATES AND MALEAMIC ACID-TERMINATED, WATER-SOLUBLE POLYMERS - Methods for preparing conjugates using polymeric reagents bearing a maleimide are provided. Also provided are compositions comprising the conjugates. | 10-25-2012 |
20120277376 | DENDRIMER CONJUGATES - The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer-linker conjugates, methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer-linker conjugates of the present invention may further comprise one or more components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy. | 11-01-2012 |
20130046056 | CHROMATOGRAPHY MATRICES INCLUDING NOVEL STAPHYLOCOCCUS AUREUS PROTEIN A BASED LIGANDS - The present invention relates to chromatography matrices including ligands based on one or more domains of immunoglobulin-binding proteins such as, | 02-21-2013 |
20130053514 | Method Involving 1-Benzotriazolyl Carbonate Esters of Poly(ethylene glycol) - The invention provides a method comprising the steps of providing a poly(ethylene glycol) having one terminal hydroxyl group; reacting the terminal hydroxyl group of the poly(ethylene glycol) with di(1-benzotriazolyl)carbonate to form a 1-benzotriazolylcarbonate ester of the poly(ethylene glycol); reacting the 1-benzotriazolylcarbonate ester of the poly(ethylene glycol) with an amino acid to form an amino acid derivative; and reacting the amino acid derivative with a biologically active agent under conditions to form a polymer-active agent conjugate. | 02-28-2013 |
20130079467 | DAMAGE SELF-REPORTING POLYMER MATERIALS HAVING AT LEAST TWO PHASES - A synthetic material ( | 03-28-2013 |
20130096258 | POLYMER CONJUGATES OF GLP-1 - Conjugates of a GLP-1 moiety may be covalently attached to one or more water-soluble polymers. For instance, a GLP-1 polymer conjugate may include a GLP-1 moiety releasably attached at its N-terminus to a water-soluble polymer. The GLP-1 polymer conjugate may include a GLP-1 moiety covalently attached to a water-soluble polymer, wherein the GLP-1 moiety possesses an N-methyl substituent. | 04-18-2013 |
20130109807 | REMOVAL OF VIRUCIDAL AGENTS IN MIXED MODE CHROMATOGRAPHY | 05-02-2013 |
20130150529 | IODINE-CONTAINING RADIAL-SHAPED MACROMOLECULAR COMPOUNDS, PREPARATION METHOD THEREOF AND CONTRAST MEDIA COMPOSITIONS FOR CT COMPRISING THE SOME - Disclosed herein is an iodine-containing radial-shaped macromolecule suitable for an active ingredient of the computed tomography (CT) contrast medium, a method to prepare the same, and a contrast medium composition including the same. With respect to the iodine-containing radial-shaped macromolecule according to the present invention, the duration of contrast enhancement has been significantly improved in comparison to that of the current small molecular contrast media compounds containing iodine. | 06-13-2013 |
20130178587 | Antibody Immobilization Using Poly(ethylene glycol) Crosslinking - Provided is a method for immobilizing a macromolecule to a solid support material using poly(ethylene glycol), and a device obtained from the method. The macromolecule can be a polypeptide, such as an antibody. | 07-11-2013 |
20130245198 | PNEUMATIC TIRE - The present invention is directed to a pneumatic tire comprising at least one component, the at least one component comprising a rubber composition comprising:
| 09-19-2013 |
20130245199 | FUNCTIONALIZED ELASTOMER - The present invention is directed to a functionalized elastomer comprising: a polymeric backbone chain derived from a monomer comprising at least one conjugated diene monomer and optionally at least one vinyl aromatic monomer; and a functional group bonded to the backbone chain, the functional group comprising an oligopeptide or modified oligopeptide. | 09-19-2013 |
20130261259 | GENETICALLY ENCODED INITIATOR FOR POLYMER GROWTH FROM PROTEINS - This invention pertains to methods for producing homogeneous recombinant proteins that contain polymer initiators at defined sites. The unnatural amino acid, 4-(2′-bromoisobutyramido)phenylalanine of formula 1, was designed and synthesized as a molecule comprising a functional group further comprising an initiator for an atom-transfer radical polymerization (‘ATRP”) that additionally would provide a stable linkage between the protein and growing polymer. We evolved a | 10-03-2013 |
20130281623 | AQUEOUS SOLUBLE FERRIMAGNETS STABILIZED BY BLOCK COPOLYMERS - The present invention relates to a water-soluble polymer complex that includes a water-soluble block copolymer and a magnetic nanoparticle, wherein the water-soluble polymer complex has a nonzero net magnetic moment in the absence of an applied magnetic field at ambient temperatures. The water-soluble block copolymer is preferably a diblock or triblock copolymer and the magnetic nanoparticle is preferably a ferrimagnetic or ferromagnetic nanoparticle. The water-soluble complexes may be derivatized with reactive groups and conjugated to biomolecules. Exemplary water-soluble polymer complexes covered under the scope of the invention include PEG | 10-24-2013 |
20130281624 | PHASE TRANSITION BIOPOLYMERS AND METHODS OF USE - The present disclosure describes environmentally responsive polypeptides capable of displaying stimuli-triggered conformational changes in a reversible or irreversible manner that may be accompanied by aggregation. Polypeptides include a number of repeated motifs and may be elastomeric or non-elastomeric. The polypeptides may be used to deliver therapeutics to a biological site and to develop bioactive polypeptides that are environmentally responsive. | 10-24-2013 |
20130317172 | METHOD FOR IMMOBILIZING TEMPERATURE RESPONSIVE PROTEIN A - A method for manufacturing a carrier having temperature responsive protein A, which is protein A mutated such that a binding property to an antibody changes depending upon temperature, immobilized thereto, wherein the temperature responsive protein A has the binding property to the antibody in a first temperature region and no binding property to the antibody in a second temperature region; and the method comprises a step of immobilizing the temperature responsive protein A to a carrier surface at a temperature within the first temperature region in which the temperature responsive protein A has the binding property to the antibody. | 11-28-2013 |
20140024776 | HIGH MOLECULAR WEIGHT ZWITTERION-CONTAINING POLYMERS - The present invention provides multi-armed high MW polymers containing hydrophilic groups and one or more functional agents, and methods of preparing such polymers. | 01-23-2014 |
20140039125 | POLYMALIC ACID-BASED MULTIFUNCTIONAL DRUG DELIVERY SYSTEM - A drug delivery system for delivering a drug payload to a specific tissue or cell type is disclosed. The system includes a polymalic acid molecular scaffold which can be used for attaching a plurality of molecular modules. Molecular modules include targeting antibodies for promoting cellular uptake by a target cell, and pro-drugs for altering cellular metabolism, for example, a pro-drug that alters expression of protein kinase CK2. | 02-06-2014 |
20140094567 | Diketopiperazine Forming Dipeptidyl Linker - The invention relates to a method for homogeneous solution phase peptide synthesis (HSPPS) of a N-terminal peptide fragment PEP-N and a C-terminal peptide fragment C-PEP, with C-PEP carrying a specific diketopiperazine (DKP) comprising C-terminal protecting group, which contains a handle group HG, with HG being connected to the C-terminus of the peptide fragment; thereby this specific DKP comprising C-terminal protecting group can be selectively cleaved from the peptide as a conventionally used C-terminal protecting group. By the use of this DKP and HG comprising C-terminal protecting group, certain process steps in convergent peptide synthesis based on a combination of HSPPS and solid phase peptide synthesis (SPPS) can be avoided. The invention relates further to a method for the preparation of such specifically protected fragment C-PEP by SPPS by using a linker comprising a specific dipeptide and HG for connecting the growing peptide chain to the resin, which linker forms said DKP group, when the peptide fragment C-PEP is cleaved from the supporting resin; and further to the intermediates of the preparation method. | 04-03-2014 |
20140107292 | COPOLYMERS AND METHODS OF USE THEREOF - Copolymers, such as block copolymers, having at least one block that is a random copolymer of ε-caprolactone and a-carboxy-s-caprolactone are disclosed. Also described are methods of using such copolymers, such as, for example, in medical devices. | 04-17-2014 |
20140128544 | Novel Heparin Entities and Methods of Use - The present invention relates to immobilized biologically active entities that retain a significant biological activity following manipulation. The invention also comprises a medical substrate comprising a heparin entity bound onto a substrate via at least one heparin molecule, wherein said bound heparin entity is heparinase-1 sensitive. | 05-08-2014 |
20140221569 | DECORATED MACROMOLECULAR SCAFFOLDS - The present invention relates to a method for preparing decorated macromolecular scaffolds. The method of the invention is useful for the generation of bioactive nanoparticles for use in clinical applications. Such applications include drag and gene delivery, tumour targeting, bioimaging, tissue remodelling, generation of antiviral products and vaccines delivery. | 08-07-2014 |
20140235789 | SOLID PHASE PEPTIDE SYNTHESIS VIA SIDE CHAIN ATTACHMENT - The present application discloses peptides and peptaibols of high purity may be obtained by solid phase peptide synthesis using as the starting resin hydroxy amino acids, hydroxy amino acid amides, hydroxy amino alcohols or small peptides containing hydroxy amino acids attached to polymers through their side chain. | 08-21-2014 |
20140256879 | METHOD FOR SYNTHESIZING PROTEINS - Method for assembling proteins from peptide fragments. It allows the production of proteins in a manner that is simple, reliable and applicable on an industrial scale. This method allows the production of proteins of therapeutic or diagnostic interest. Kits for applying this synthesis method as well as test and/or diagnostic kits are also described. | 09-11-2014 |
20140275420 | ATOM TRANSFER RADICAL POLYMERIZATION UNDER BIOLOGICALLY COMPATIBLE CONDITIONS - Methods for conducting controlled grafting-from radical polymerizations from biomolecules under conditions that are biologically compatible are described. The methods provide biomolecule-polymer conjugates with highly controlled structures and narrow polydispersities under aqueous reaction conditions and biological temperatures. Biomolecules, such as proteins and nucleotides can be conjugated to polymers with high levels of control. | 09-18-2014 |
20140296434 | CHROMATOGRAPHY MATRICES INCLUDING NOVEL STAPHYLOCOCCUS AUREUS PROTEIN A BASED LIGANDS - The present invention relates to chromatography matrices including ligands based on one or more domains of immunoglobulin-binding proteins such as, | 10-02-2014 |
20140296435 | PHARMACEUTICAL COMPOSITION OF CHELATING COMPLEX MICELLES - This invention provides Chelating Complex Micelles as a drug carrier. The Chelating Complex Micelles can load drugs without changing their structure, and therefore extend the half-life of drugs in the human body. The chelating complex micelles contain a metal ion core, at least one polymer, and at least one drug molecule. The metal ion is considered as a Lewis acid while polymer chain and drug molecules are referred to as Lewis bases. The drug molecule is linked to the polymer via forming coordinate bonds with metal ion, and then self-assembled to form chelating complex micelles as a drug carrier. | 10-02-2014 |
20140343227 | Diketopiperazine Forming Dipeptidyl Linker - The invention relates to a method for homogeneous solution phase peptide synthesis (HSPPS) of a N-terminal peptide fragment PEP-N and a C-terminal peptide fragment C-PEP, with C-PEP carrying a specific diketopiperazine (DKP) comprising C-terminal protecting group, which contains a handle group HG, with HG being connected to the C-terminus of the peptide fragmcnt; thereby this specific DKP comprising C-terminal protecting group can be selectively cleaved from the peptide as a conventionally used C-terminal protecting group. By the use of this DKP and HG comprising C-terminal protecting group, certain process steps in convergent peptide synthesis based on a combination of HSPPS and solid phase peptide synthesis (SPPS) can be avoided. The invention relates further to a method for the preparation of such specifically protected fragment C-PEP by SPPS by using a linker comprising a specific dipeptide and HG for connecting the growing peptide chain to the resin, which linker forms said DKP group, when the peptide fragment C-PEP is cleaved from the supporting resin; and further to the intermediates of the preparation method. | 11-20-2014 |
20140350183 | CHROMOPHORIC POLYMER DOTS WITH NARROW-BAND EMISSION - Polymers, monomers, chromophoric polymer dots and related methods are provided. Highly fluorescent chromophoric polymer dots with narrow-band emissions are provided. Methods for synthesizing the chromophoric polymers, preparation methods for forming the chromophoric polymer dots, and biological applications using the unique properties of narrow-band emissions are also provided. | 11-27-2014 |
20150018486 | Nanotherapeutic Colloidal Metal Compositions and Methods - The present invention comprises compositions and methods for delivery systems of agents, including therapeutic compounds, pharmaceutical agents, drugs, detection agents, nucleic acid sequences and biological factors. In general, the nanotherapeutic compositions of the present invention comprise a platform comprising a colloidal metal, a targeting ligand such a tumor necrosis factor, a stealth agent such as polyethylene glycol, and one or more diagnostic or therapeutic agents for delivery. The invention also comprises methods and compositions for making such nanotherapeutic compositions and for the treatment of cancer. | 01-15-2015 |
20150025196 | POLYOXAZOLINE POLYMERS AND METHODS FOR THEIR PREPARATION, CONJUGATES OF THESE POLYMERS AND MEDICAL USES THEREOF - The present invention relates to functionalized ploy(2-oxazoline) polymers, which are very suitable as a carrier and/or delivery vehicle (conjugate) of drugs, such as small therapeutic molecules and bio-pharmaceuticals. These polymers are characterized in that they comprise repeating units that are represented by the following formula —[N(R | 01-22-2015 |
20150031832 | CARRIER NANOPARTICLES AND RELATED COMPOSITIONS, METHODS AND SYSTEMS - Carrier nanoparticles comprising a polymer containing a polyol coupled to a polymer containing a boronic acid, configured to present the polymer containing a boronic acid to an environment external to the nanoparticle and related compositions, methods and systems. | 01-29-2015 |
20150038645 | BIOMIMETIC ADHESIVE COMPOSITIONS COMPRISING A PHENOLIC POLYMER AND METHODS FOR USE THEREOF - Biomimetic adhesive compositions can be used in various aspects of subterranean treatment operations. Methods for treating a subterranean formation can comprise: providing an adhesive composition that comprises a first polymer comprising a plurality of monomers that comprise a phenolic moiety, a biopolymer that is crosslinkable with the first polymer, a crosslinking agent, and an oxidizing agent; introducing the adhesive composition into a subterranean formation; and forming a coacervate-bound surface in the subterranean formation by crosslinking the first polymer. | 02-05-2015 |
20150045506 | NATIVE LIGATION PROCESS - A method for producing a polypeptide, includes at least one native ligation step using a peptide functionalized with a selenium group. The selenium peptides and compounds are also described. | 02-12-2015 |
20150087783 | FORMALDEHYDE-FREE PROTEIN-CONTAINING BINDERS FOR SPUNBOND PRODUCTS - One-part binder compositions are described that may include a protein and a crosslinking combination. The crosslinking combination may include at least a first crosslinking compound and a second crosslinking compound. The first and second crosslinking compounds are individually crosslinkable with each other and with the protein. Examples of the protein include soy protein. Fiber products and methods of making the fiber products are also described. The fiber products may include organic fibers, inorganic fibers, or both, in a cured thermoset binder based on solutions of the one-part binder compositions. | 03-26-2015 |
20150094422 | BIODEGRADABLE POLYMERS WITH PENDANT FUNCTIONAL GROUPS ATTACHED THROUGH AMIDE BONDS - Amide compounds are defined and are polymerized to create polyesters and polyurethanes having amide units bearing a pendant functional group, where the nitrogen atom of the amide group is part of the polymer backbone. The pendant functional group of the functionalized amide polymer may be modified or added by post polymerization functionalization of the functionalized amide polymer. The pendant functional group of the functionalized amide polymer may include a protecting group that may be removed after polymerization. The pendant functional groups of the functionalized amide polymers may be used to modulate the physical, chemical and biological properties of the polymers. | 04-02-2015 |
20150112022 | PHASE TRANSITION BIOPOLYMERS AND METHODS OF USE - The present disclosure describes environmentally responsive polypeptides capable of displaying stimuli-triggered conformational changes in a reversible or irreversible manner that may be accompanied by aggregation. Polypeptides include a number of repeated motifs and may be elastomeric or non-elastomeric. The polypeptides may be used to deliver therapeutics to a biological site and to develop bioactive polypeptides that are environmentally responsive. | 04-23-2015 |
20150141574 | THERMOPLASTIC ELASTOMERS CONTAINING AN OLIGOPEPTIDE HARD COMPONENT - The present invention is generally directed to a new class of TPEs made from peptide terminated low T | 05-21-2015 |
20150148486 | METHOD OF IMMOBILIZING BIOLOGICALLY ACTIVE SUBSTANCE - An object of the present invention is to provide a method of immobilizing the biologically active substance which has an excellent capability of immobilizing a target biologically active substance, and exhibits low nonspecific adsorption of the biologically active substance to provide a high S/N ratio, without using a functional group for fixing the biologically active substance and without having a process of inactivating the functional group for fixing the biologically active substance after immobilizing the biologically active substance. The above object is achieved by a method of immobilizing a biologically active substance comprising the step of: bringing a solution into contact with a compound-side surface of an immobilizing substrate to immobilize the biologically active substance on a surface of the immobilizing substrate, the solution being prepared by dissolving the biologically active substance in a phosphate buffer having a phosphate concentration of 0.1 M or more, and the immobilizing substrate comprising a substrate and a compound containing a hydrophilic group inhibiting nonspecific adsorption on a surface of the substrate. | 05-28-2015 |
20150314008 | AURISTATIN COMPOUNDS AND CONJUGATES THEREOF - An auristatin compound conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -L | 11-05-2015 |
20150376297 | METHOD FOR REFOLDING ANTIBODY, PROCESS FOR PRODUCING REFOLDED ANTIBODY, REFOLDED ANTIBODY, AND USES THEREOF - A method for refolding an antibody, a process for producing a refolded antibody, a refolded antibody, and uses thereof are provided. A method for refolding an antibody in a liquid phase comprises the steps of denaturing an inactive antibody binding directly or through a linker to a peptide, the peptide having an isoelectric point lower than the isoelectric point of the inactive antibody, and dispersing in a liquid phase the peptide-binding inactive antibody denatured in the step above. Also provided is a process for producing a refolded antibody. | 12-31-2015 |
20160025735 | Novel Reagents for Directed Biomarker Signal Amplification - Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods. | 01-28-2016 |
20160031962 | SOLID PHASE PEPTIDE SYNTHESIS OF INSULIN USING SIDE CHAIN ACHORED LYSINE - The present application discloses the preparation of peptides, including insulin and insulin derivatives, using efficient methods for solid-phase and solution phase peptide synthesis. | 02-04-2016 |
20160075734 | PEPTOID AFFINITY LIGANDS - Compounds of Formulas I: | 03-17-2016 |
20160082121 | BISPECIFIC INTRACELLULAR DELIVERY VEHICLES - A composition for delivering an agent to a cell, comprising a bispecific affinity reagent and a pH-responsive, membrane destabilizing polymer. The bispecific affinity reagent may include a first affinity reagent covalently linked to a second affinity reagent, wherein the first affinity reagent binds to a molecule on the surface of a cell, and the second affinity reagent binds to an intracellular target. | 03-24-2016 |
20160083516 | CROSSLINKED POLY-DEPSIPEPTIDE COPOLYMERS AND METHODS OF MAKING THEREOF - Aspects of the present disclosure include methods for preparing crosslinked polydepsipeptide copolymers by stereolithography (e.g., 3-D printing). In practicing methods according to certain embodiments, a crosslinkable copolymer containing a depsipeptide having one or more hydrolysable crosslinkers is photocrosslinked by stereolithography to produce a crosslinked polydepsipeptide copolymer. In certain embodiments, methods include contacting the crosslinkable poly(depsipeptide-co-ε-caprolactone) copolymer precursor with one or more bioactive agents and photocrosslinking by 3-D printing to produce a crosslinked poly(depsipeptide-co-ε-caprolactone) copolymer with incorporated bioactive agent. Crosslinkable polydepsipeptide copolymer precursors and crosslinked polydepsipeptide copolymers are also described. | 03-24-2016 |
20160089445 | DERIVATISATION OF BIOLOGICAL MOLECULES - The present disclosure relates to a new polymerisation process in which ethylenically unsaturated monomers are polymerised by a living radical polymerisation process in the presence of an initiator and a catalyst. Polymers produced by this new process are also thought to be novel and may be used to derivatise biological molecules to improve their efficacy as therapeutic treatments. A preferred polymer is of formula | 03-31-2016 |
20160096920 | PROCESS FOR THE PREPARATION OF AN OBJECT SUPPORTING A LIPID BILAYER - A process for the preparation of an object, supporting a lipid bilayer, for use in tissue engineering including the steps of providing an object having a surface, treating the surface of the object with a plasma containing active oxygen to provide the surface of the object with reactive groups A, to provide the surface of the object with reactive groups A, covalently attaching a sterol group to the reactive groups A and contacting the object activated with sterol groups with a lipid solution to form a lipid bilayer. | 04-07-2016 |
20160122451 | ENZYME-CATALYZED SYNTHESIS OF SITE-SPECIFIC AND STOICHIOMETRIC BIOMOLECULE-POLYMER CONJUGATES - Methods for producing polypeptide-polymer conjugates include attachment of an initiator agent to a polypeptide specifically at the C-terminus of the polypeptide using a sortase enzyme and in situ polymerization of a polymer from the C-terminus. The polypeptide-polymer conjugates may have desirable pharmacological properties and may be used therapeutically. | 05-05-2016 |
20160137689 | PEPTIDE-RESIN CONJUGATE AND USE THEREOF - The present invention relates to a peptide-resin conjugate of Formula (2), wherein: Pr | 05-19-2016 |
20160175450 | DRUG DELIVERY OF TEMOZOLOMIDE FOR SYSTEMIC BASED TREATMENT OF CANCER | 06-23-2016 |
20160184444 | MICROPARTICLES CONTAINING PHYSIOLOGICALLY ACTIVE PEPTIDE, METHOD FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME - Disclosed are microparticles containing physiologically active peptides, a method for preparing the same, and a pharmaceutical composition comprising the same. | 06-30-2016 |
20160193348 | MUCOUS LAYER-ADHESIVE POLY-r-GLUTAMIC ACID NANOMICELLES AND DRUG DELIVERY SYSTEM USING SAME | 07-07-2016 |
20190144567 | AQUEOUS BIOMOLECULE COUPLING ON CO2-PLASMA-ACTIVATED SURFACES | 05-16-2019 |
20220134309 | AFFINITY DISSOLUTION OF BIOMOLECULES FOR PROTEIN PURIFICATION - Protein-based affinity ligands, in which the protein has an affinity for a target protein and includes a covalently attached polyelectrolyte, and methods for using the same to purify proteins are described herein. | 05-05-2022 |