Entries |
Document | Title | Date |
20080275139 | Cyclodextrin-Containing Polymers and Uses Thereof - The invention provides a cyclodextrin-containing polymer comprising one or more cyclodextrin residues. The polymer is selected from a peptide, a polypeptide, an oligonucleotide or a polynucleotide or a mixture thereof. The peptide or polypeptide has at least one amino acid residue containing a functional side group and at least one of the cyclodextrin residues is covalently linked to the functional side group of the amino acid residue of said peptide or polypeptide or to the sugar moiety of a nucleotide residue of the oligonucleotide or polynucleotide. | 11-06-2008 |
20080287551 | CAROTENOID FORMULATION - The present invention discloses the use of a lycopene coated with a water non-soluble thin film comprising amphiphilic protein polymer for coloring with red color, foods, pharmaceuticals or cosmetics having fat and/or oil contents higher than 5%. The invention further discloses a process for the preparation of stable lycopene formulation comprising (a) treating an isolated protein to form a protein in a molecular form; (b) dispersing lycopene in an aqueous solution comprising an isolated protein in a molecular form; (c) grinding said dispersion to form lycopene particle size of 1 to 10 μm forming an homogenized mixture comprising fine particles; and optionally (d) drying the homogenized mixture. | 11-20-2008 |
20090036553 | DENDRITIC ENCAPSULATION OF ACTIVE AGENTS - A pharmaceutical composition comprising an active agent bound to a scaffold for dendritic encapsulation wherein said scaffold is covalently or non-covalently attached to a polysaccharide. More specifically, the invention is directed to active agent complexes or conjugates which utilize dendritic encapsulation alone or in combination with other delivery systems to improve and target active agent release. | 02-05-2009 |
20090054536 | PALATABLE SUPPORT OF IMPROVED FORMULA - A palatable support is intended to at least partially wrap an active substance that is initially independent of the support. The support of the invention is remarkable in that it includes, as a percentage by weight based on the total weight of the support, 3% to 50% of glucose syrup, the dextrose equivalent (DE) of the glucose syrup being in the range 5 to 60. | 02-26-2009 |
20090076176 | Prodrugs activated by plasmin and their use in cancer chemotherapy - The product of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide having a plasmin peptide substrate of 2-4 amino acids and mono- or di-peptide linkage, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by plasmin. Also disclosed are methods of making and using the prodrug compounds. | 03-19-2009 |
20090093551 | REMOTELY TRIGGERED RELEASE FROM HEATABLE SURFACES - The present invention provides particle conjugates for drug delivery. Such conjugates comprise one or more heatable surfaces, one or more thermally-responsive linkers, and one or more agents to be delivered. In some embodiments, conjugates and populations of conjugates can be used to treat and/or diagnose a disease, disorder, and/or condition. The present invention provides methods for producing and/or using thermally-responsive conjugates. | 04-09-2009 |
20090124708 | Collagenous tissue compositions - Implant compositions are disclosed consisting of a biocompatible carrier medium such as a saline or dextran solution and particles of collagenous material dispersed therein. The collagenous material is derived from tissue which has been milled to provide fragments of collagen fibres which preserve the architecture of the original fibres and their molecular structure. The collagenous material is also substantially free of non-fibrous tissue proteins, glycoproteins, cellular elements and lipids or lipid residues, and is non-cytotoxic. By suitable choice of particle size and concentration, the composition may be presented in injectable form or as a paste. The compositions are suitable for application in cosmetic and reconstruction surgery. | 05-14-2009 |
20090143487 | Enhanced stability of proteins immobilized on nanoparticles - This invention is directed to the application of a previously unknown property of nanomaterials—its ability to enhance protein activity and stability at high temperatures, in organic solvents, and in polymer composites. Nanomaterials such as single-walled carbon nanotubes (SWNTs) can significantly enhance enzyme function and stability in strongly denaturing environments. Experimental results and theoretical analysis reveal that the enhancement in stability is a result of the curvature of these nanoscale materials, which suppresses unfavorable protein-protein interactions. The enhanced stability is also exploited in the preparation of highly stable and active nanocomposite films that resist nonspecific protein absorption, i.e., inhibit fouling of the films. The protein-nanoparticles conjugates represent a new generation of highly selective, active, and stable catalytic materials. Furthermore, the ability to enhance protein function by interfacing them with nanomaterials has a profound impact on applications ranging from biosensing, diagnostics, vaccines, drug delivery, and biochips, to novel hybrid materials that integrate biotic and abiotic components. | 06-04-2009 |
20090143488 | Peptides imparting umami, salt, dairy and bitter flavor - The invention relates to compositions and methods of using the flavor active peptides, Lys-Ile-His-Pro-Phe (SEQ ID NO:1), Gly-Pro-Phe-Pro-Ile (SEQ ID NO:2), and Lys-Lys-Tyr-Lys-Val-Pro-Gln (SEQ ID NO:3), to impart a bitter, salt, dairy or umami flavor to food or pharmaceutical products. In particular embodiments, the Lys-Lys-Tyr-Lys-Val-Pro-Gln (SEQ ID NO:3) peptide further imparts a vegetable, brothy, or bready flavor. | 06-04-2009 |
20090156691 | CELL CULTURE CARRIER IMPLANTABLE IN VIVO - A cell cultivation carrier implantable in vivo having independent pore with opening of 100 μm-1000 μm on the surface thereof produced by neutralization•gellation of collagen acidic solution, said collagen acidic solution is preliminary prepared by passing through a filter of 10 μm or less pore size by 5-20 mg/mL concentration. Especially, a cell cultivation carrier implantable in vivo having sufficiently self-organized accumulation shape•structure obtained by carrying out said neutralization under directionally supplying of alkali. | 06-18-2009 |
20090156692 | USE OF OLIGOMERS AND POLYMERS FOR DRUG SOLUBILIZATION, STABILIZATION, AND DELIVERY - The invention relates to the use of oilgomers and polymers capable of rendering insoluble drugs soluble, protecting unstable drugs, and facilitating the delivery of drugs to their site of action. This invention further relates to processes for the preparation of such oilgomers and polymers, and to compositions containing them. | 06-18-2009 |
20090170959 | POLYMER CARRIER - Compositions and methods for delivering bioactive agents, such as vitamins, hormones, nutrients and drugs, by stabilizing and or solubilizing these agents in a polymer matrix. The carrier polymers can be used in drug delivery and are useful for delivery of small molecules. The carrier polymers also can be used in scaffolds for regenerative medicine | 07-02-2009 |
20090170960 | PEPTIDE LIPID-CONTAINING CARRIER AND METHOD FOR INTRODUCING COMPOUND INTO CELLS USING SAME - The present invention provides a carrier capable of highly efficiently introducing a compound into cells with low cytotoxicity, which contains peptide lipids represented by the following formula, and a method for introducing a compound into cells using the carrier: wherein R | 07-02-2009 |
20090176892 | Soluble Hydrophobic Core Carrier Compositions for Delivery of Therapeutic Agents, Methods of Making and Using the Same - The present invention relates to a soluble hydrophobic-core carrier composition comprising (i) a linear polymeric backbone; (ii) a plurality of hydrophilic polymeric protective chains covalently linked and pendant to the polymeric backbone and (iii) at least one hydrophobic moiety covalently linked and pendant to the polymeric backbone. In certain embodiments, the weight ratio of hydrophilic protective chains to hydrophobic moieties in the carrier is at least 15:1. In other embodiments, at least 90% of the residues of the polymeric backbone are coupled to a hydrophilic polymeric protective chain or a hydrophobic moiety. In other embodiments, the composition further comprises (iv) a hydrophobic load molecule dissociably linked to the hydrophobic moiety of the carrier. | 07-09-2009 |
20090221718 | METADHERIN POLYPEPTIDES, ENCODING NUCLEIC ACIDS AND METHODS OF USE - Metadherin, a protein that controls metastasis, and variants of metadherin are described. DNA sequences encoding the same and methods of production are described. Therapies involving the application of metadherin, binding agents that bind to metadherin, such as antibodies, and expression modulating agents, such as siRNA, are described. The use of metadherin or metadherin variants for delivering desired substances to particular lung tissue is described. A method of diagnosing metastatic cells based on the presence of metadherin is described. | 09-03-2009 |
20090253809 | BIOABSORBABLE ELASTOMERIC POLYMER NETWORKS, CROSS-LINKERS AND METHODS OF USE - The invention provides elastomeric polymer networks and semi-interpenetrating networks in which a linear PEA, PEUR or PEU polymer is crosslinked by ester or alpha-amino-acid containing cross-linkers that polymerize upon exposure to active species. Bioabsorbable elastomeric internal fixation devices fabricated using such polymer networks and semi-interpenetrating networks are useful for in vivo implant and delivery of a variety of different types of molecules in a time release fashion. Alpha-amino-acid containing ester amide cross-linkers are also provided by the invention. | 10-08-2009 |
20090253810 | OSTEOINDUCTIVE PUTTIES AND METHODS OF MAKING AND USING SUCH PUTTIES - The present disclosure relates to osteoinductive putties and other implantable compositions for repair of bone defects and other medical uses. Specifically, the technology pertains to carriers for use in implantable compositions, such as osteoinductive putties. The osteoinductive putties are made entirely from donor tissue such as demineralized bone matrix, and the putties have excellent physical properties. The present disclosure relates to osteoinductive putties, carriers, compositions, implants, kits, methods of making and methods of using any of the foregoing. | 10-08-2009 |
20090258954 | PROTECTIVE HYDROCOLLOID FOR ACTIVE INGREDIENTS - (Modified) rice endosperm protein is used as novel protective hydrocolloid for active ingredients, especially fat-soluble active ingredients and/or colorants. Included are compositions comprising (modified) rice endosperm protein and at least one active ingredient and to their manufacture, as well as to the (modified) rice endosperm protein itself and its manufacture. These compositions are used for the enrichment, fortification and/or coloration of food, beverages, animal feed, personal care or pharmaceutical compositions, and to food, beverages, animal feed, personal care and pharmaceutical compositions containing such a (modified) rice endosperm protein and such a composition, respectively. | 10-15-2009 |
20090298955 | ALTERED VIRUS CAPSID PROTEIN AND USE THEREOF - An altered capsid protein of a primate-infective papovavirus in which a foreign peptide sandwiched by 1 to several glycine residues at each end is inserted into at least one of the DE-loop or the HI-loop of the capsid protein of the primate-infective papovavirus, and a virus-like particle formed from the altered capsid protein. | 12-03-2009 |
20090306227 | TABLET FOR REMOVING TONGUE COATING - A tablet for removing tongue coating, wherein the tablet contains highly soluble saccharide and lowly soluble saccharide, the highly soluble saccharide and the lowly soluble saccharide are water-soluble, of water-soluble saccharides contained as the primary component in the tablet, the highly soluble saccharide has the highest solubility in water at 37° C., the highly soluble saccharide is a saccharide having the highest solubility in water at 37° C. among the water-soluble saccharides contained in the tablet as the main components, the lowly soluble saccharide is a saccharide having the lowest solubility in water at 37° C. among the water-soluble saccharides contained in the tablet as the main components, and the difference between the solubility of the highly soluble saccharide in water at 37° C. and the solubility of the lowly soluble saccharide in water at 37° C. is 10% by weight or more. | 12-10-2009 |
20100041773 | DISRUPTORS OF EARLY/RECYCLING ENDOSOMES - A delivery system for introducing a cargo molecule into cytosol of a living cell can include: a first membrane binding element linked to an endosomal compartment disrupting element through a first linker having one or more anionic moieties; and a second membrane binding element linked to an exogenous cargo molecule through a second linker having one or more anionic moieties, the second linker having a region that is selectively cleavable, wherein the first and second membrane binding elements both induce endocytosis into an early/recycling endosome and the endosomal compartment disrupting element destabilizes the early/recycling endosome such that the exogenous cargo molecule is released from the second membrane binding element and into the cytosol of the living cell. | 02-18-2010 |
20100197808 | METHOD FOR IDENTIFYING MHC ALLELES IN DOGS - A method for identifying one or more MHC alleles present in a dog, the method comprising: (a) determining the nucleotide present at the or each polymorphic position specified for the one or more MHC alleles in any one of Tables 4 to 6 or determining the nucleotide(s) present at a polymorphic position(s) in linkage disequilibrium with one or more polymorphic positions specified in Tables 4 to 6; and (b) identifying therefrom the presence or absence of one or more MHC alleles in the dog. Based on the comparison between alleles, it was possible to specify a minimum number of SMP positions that need to be determined in order to identify a particular allele (Table 4 to 6). | 08-05-2010 |
20100197809 | SKIN SOLUTION AND PREPARATION METHOD THEREOF - A skin solution for transporting molecules with high molecular weight to the skin, and/or moisturizing the epidermal tissues of the skin, and/or alternating the membrane permeability of the skin, and/or softening any type of callus, corns, nail folds or dry skin and facilitating the removal of the same. A method for preparing the skin solution, the solution being sprayable to form tiny droplets to be readily absorbed by the skin. | 08-05-2010 |
20100197810 | OIL-IN-WATER EMULSIONS - Improved oil-in-water emulsions are provided and a method for their manufacture. In particular, the emulsions comprise a means to control delivery of oil-soluble or water-soluble actives in a core comprising a liquid oil or gel oil continuous phase, which actives can be delivered with improved deposition to surfaces such as, in particular, the skin, gastro-intestinal tract and that defined by the oral cavity. The emulsions are also noted for their improved stability. | 08-05-2010 |
20100240774 | USE OF HYDROPHOBIN POLYPEPTIDES AS PENETRATION ENHANCERS - The present invention relates to the use of hydrophobin polypeptides as penetration intensifiers. | 09-23-2010 |
20100267846 | MOLECULAR DELIVERY VEHICLE - An isolated caveolin containing vesicle comprising a caveolin protein and at least one lipid, wherein at least about 30% of the at least one lipid is selected from phosphatidylethanolamine and phosphatidylglycerol is disclosed. Also disclosed is a method of making an isolated caveolin containing vesicle, an isolated caveolin containing vesicle comprising a recombinant caveolin protein, an isolated caveolin containing delivery vesicle, a method of making an isolated caveolin containing delivery vesicle and a method of treatment of a disease or condition by delivery of a molecule using the isolated caveolin containing delivery vesicle. | 10-21-2010 |
20110039949 | PET FOOD PRODUCT AND METHOD OF MANUFACTURE - A pet food is provided, comprising a sorbent food body and a fluid carrier comprising a functional ingredient absorbed into the body. The body preferably is realtively moist, having a moisture content for example of from 35% to 60% by weight and firm structure that is resilient under initial biting by a pet animal. Protein content is preferably at least 20% by weight. The sorptivity of the body is increased by depleting the body of a first liquid, for example by causing drying by exposure to a source of dry heat, such as in roasting, grilling, frying and baking. Methods of manufacture are disclosed including providing a sorptive food body, causing the body to take up a carrier fluid containing a functional ingredient and packing the body in suitable packaging. The invention further provides delivery means for delivering a functional ingredient to a pet animal, the delivery means comprising a sorbent food body with the functional ingredient absorbed therein. The functional ingredient may be a nutrient or a pharmaceutical. | 02-17-2011 |
20110077308 | Agonists of Bitter Taste Receptors and Uses Thereof - The present invention relates to agonists of the human bitter-taste receptor hTAS2R40 and their role in bitter taste transduction. The invention also relates to assays for screening molecules that modulate, e.g. suppress or block hTAS2R40 bitter taste transduction or bitter taste response. | 03-31-2011 |
20110077309 | HUMECTANT COMPOSITION - The present invention relates to a humectant composition containing, as component (A), at least one member selected from a menthol derivative represented by the following formula (1) and p-menthane-3,8-diol: | 03-31-2011 |
20110082220 | PORCINE UMAMI TASTE RECEPTORS AND USES THEREFOR - The present invention provides nucleic acids encoding porcine taste receptors, polypeptides encoded by the nucleic acids, and methods of using the nucleic acids and polypeptides to identify compounds that enhance umami taste. | 04-07-2011 |
20110124743 | PALATABILITY ENHANCERS AND METHODS FOR ENHANCING PALATABILITY - The invention provides palatability enhancers containing at least one animal digest and at least one surfactant and methods for using such palatability enhancers to enhance the palatability of comestible compositions. | 05-26-2011 |
20110130472 | PROTEOSE PEPTONE FRACTION - The present invention generally relates to compositions comprising the proteose peptone fraction (PPf). In particular, the present invention relates to a method for the production of an extract comprising a demineralised protein fraction depleted in β-lactoglobulin and enriched in the PPf and to uses of these extracts, e.g. in a food product, a food supplement, a nutritional, a pharmaceutical and/or a cosmetic composition, for example as emulsifier or as foaming agent. The PPf fraction of the present invention may be obtained by adjustment of the pH of an aqueous native protein dispersion to about 5.6 to 8.4, or to about 3.5 to 5.0, heating the aqueous native protein dispersion to about 70-95° C. for about 10 seconds to 60 minutes, removing at least a part of the formed solid large molecular weight aggregates with a diameter of at least 100 nm from the aqueous protein dispersion after heating and collecting the remaining liquid fraction of the dispersion. | 06-02-2011 |
20110172315 | COMPOSITION FOR CRYOPRESERVATION OF CELLS AND TISSUES - A composition for cryopreservation of cells and tissues of human and other animals in a safe manner without using toxic substances such as DMSO, as well as for freeze preserving or freeze-drying of foods and pharmaceuticals. In examples, ε-poly-L-lysine is reacted with succinic anhydride so that 60% or more of amino groups are blocked; and, thus obtained polymer compound is added to Dulbecco-modified eagle MEM culture medium (DMEM) on market sale to form a cryopreservation liquid. In examples for foods or pharmaceuticals, the ε-poly-L-lysine derivative was added by 0.5-10 wt % to curb freeze concentration. | 07-14-2011 |
20110269849 | Emulsions and Methods for the Preparation Thereof, and Methods for Improving Oxidative Stability of Lipids - An emulsion includes a lipid, an emulsifier, and ε-polylysine. A method for improving oxidative stability of a lipid includes forming an emulsion that includes the lipid, an emulsifier, and ε-polylysine, such that the emulsion further includes a complex layer at an oil-water interface configured to provide a physical and/or electrostatic barrier against oxidation of the lipid. A method for preparing an emulsion includes combining a lipid, an emulsifier, and ε-polylysine in a mixture; and homogenizing the mixture to provide an emulsion. | 11-03-2011 |
20120046369 | Methods for enhancing the stability of foods, beverages, and cosmetics using natural products derived from non-allergenic proteinaceous sources - The present invention relates to compositions with effective metal chelating activity and utility as natural antioxidants in food, beverages, nutritional supplements and cosmetics. The compositions of the present invention may be prepared by enzymatically hydrolyzing hypoallergenic protein isolates derived from vegetables, for example yellow pea ( | 02-23-2012 |
20120059070 | POWDEROUS FORMULATIONS OF FAT-SOLUBLE ACTIVE INGREDIENTS - Stable powderous formulations containing a fat-soluble active ingredient, e.g., vitamin A, in a matrix of a native lupin protein composition are disclosed. | 03-08-2012 |
20120101172 | LIQUID OR POURABLE PROTEOSOME-FORMING BATH AND SHOWER CONCENTRATES, GALENIC APPLICATION PRODUCTS THEREOF, AND THEIR USE - The invention relates to balneological preparations, especially bath and shower preparations, which, as a pourable or liquid premixture concentrate, contain liposome-forming components, such as phospholipids, in addition to natural and/or synthetic lipids, and are also provided as mixtures containing primarily vegetable proteins, surfactants, and optional additives. When entering in contact with an excess of water, the stable systems directly form skin-active proteoliposomes having a catalytic activity for enhancing transfer of active ingredients into the skin. The stable systems can be used directly or in diluted or solid forms of application (such as lipid-containing proteasome shower preparation, proteasome bath powder, and the like). | 04-26-2012 |
20120149781 | STEM CELL DIFFERENTIATION USING NOVEL LIGHT-RESPONSIVE HYDROGELS - This application discloses a light-responsive hydrogel-based platform that can modulate multiple microenvironmental signals to direct the differentiation of human induced pluripotent stem cell-derived neural progenitor cells (hiPSC-NPCs) into neuronal cells. The invention provides novel methods for directing differentiation of neural stem cells into neurons useful for treatment of degenerative diseases or disorders, including but not limited to Alzheimer's, Parkinson's, or spinal cord injury (SCI). | 06-14-2012 |
20120149782 | CAROTENOID COMPOSITIONS CONTAINING MODIFIED GUM ACACIA - Compositions containing modified gum acacia, less than 40% oil and carotenoids, where the gum acacia has been subjected to a heat-treatment at a temperature between 100° C. and 115° C. for 1 to 38 hours. These compositions allow preparation of emulsions having a very high color intensity and color stability and useful for the enrichment, fortification and/or coloration of food beverages, animal feed, cosmetics or pharmaceutical compositions. | 06-14-2012 |
20120289610 | OIL GEL - The present invention relates to the field of oil thickeners and in particular oil gels. Embodiments of the present invention relate for example to a an oil composition containing at least one complex comprising an oil dispersible emulsifier and protein fibres and preparations comprising such oil compositions; the use of such complexes as oil thickeners, and a method to produce the complexes. | 11-15-2012 |
20130005833 | PHOTO-RESPONSIVE SUPRAMOLECULAR HYDROGELS - Compounds represented by general Formula I may form photo-responsive hydrogels that can be modulated between a non-viscous liquid state and a hydrogel. Formula I is: | 01-03-2013 |
20130030059 | T1R HETERO-OLIGOMERIC TASTE RECEPTORS, CELL LINES THAT EXPRESS SAID RECEPTORS, AND TASTE COMPOUNDS - The invention relates to compounds that specifically bind a T1R1/T1R3 or T1R2/T1R3 receptor or fragments or sub-units thereof. The present invention also relates to the use of hetero-oligomeric and chimeric taste receptors comprising T1R1/T1R3 and T1R2/T1R3 in assays to identify compounds that respectively respond to umami taste stimuli and sweet taste stimuli. Further, the invention relates to the constitutive of cell lines that stably or transiently co-express a combination of T11 and T1R3; or T1R2 and T1R3; under constitutive or inducible conditions. The use of these cells lines in cell-based assays to identify umami and sweet taste modulatory compounds is also provided, particularly high throughput screening assays that detect receptor activity by use of fluorometric imaging. | 01-31-2013 |
20130041043 | EXCIPIENT FROM TRIGONELLA FOENUM-GRACEUM SEEDS AND PROCESS FOR PREPARATION THEREOF - An excipient from | 02-14-2013 |
20130059928 | METHOD FOR PREPARING ALKALINE HYDROLYSATES OF PLANT PROTEINS - A method for preparing alkaline hydrolysates of plant proteins, which includes the following steps: 1) preparing a suspension of proteins selected from the group consisting of pea proteins, potato proteins and maize proteins, at a dry matter content of between 10 and 15%; 2) adjusting the pH, with stirring, to a value between 9.5 and 10.5 using, as the only alkaline agent, one or more alkali metal hydroxides selected from the group consisting of sodium hydroxide and potassium hydroxide; 3) heating the resulting suspension at a temperature between 70 and 80° C., for 4 to 6 hours; 4) neutralizing said heated suspension using an inorganic acid, preferably hydrochloric acid; 5) drying the neutralized suspension so as to obtain the alkaline hydrolysate. | 03-07-2013 |
20130079421 | MALLEABLE HYDROGEL HYBRIDS MADE OF SELF-ASSEMBLED PEPTIDES AND BIOCOMPATIBLE POLYMERS AND USES THEREOF - Hybrid hydrogels formed of a plurality of peptides that are capable of self-assembling into a hydrogel in an aqueous solution and a biocompatible polymer that is characterized by high swelling capability, high elasticity and low mechanical strength are disclosed, with exemplary hybrid hydrogels being formed of a plurality of aromatic dipeptides and hyaluronic acid. The hybrid hydrogels are characterized by controllable mechanical and biological properties which can be adjusted by controlling the concentration ratio of the peptides and the polymer, and which average the mechanical and biological properties of the peptides and the polymer. Processes of preparing the hydrogels and uses thereof in pharmaceutical, cosmetic or cosmeceutic applications such as tissue engineering and/or regeneration are further disclosed. | 03-28-2013 |
20130102690 | COLLAGEN-POLYSACCHARIDE MATERIALS MIMICKING BLOOD VESSELS, TISSUES AND BONES FOR MEDICAL, PHARMACEUTICAL AND ORTHOPEDIC APPLICATIONS, AND PROCESSES FOR PRODUCING THE SAME - Provided is a collagen-cellulose material containing, based on a total weight of the collagen-cellulose material: 1.0-9.0 wt. % of a collagen; 0.2-3.0 wt. % of cellulose or a derivative thereof; 0.5-6.5 wt. % of at least one acid selected from an inorganic acid, an organic acid, and mixtures thereof; and water. Also provided is a process for producing the collagen-cellulose material. Also provided is an artificial blood vessel containing the collagen-cellulose material which is in the form of a hollow tube, an artificial tissue containing the collagen-cellulose material which is in the form of a sheet, and an artificial bone containing the collagen-cellulose material which is in the form of a solid. Also provided is a medical device containing the collagen-cellulose material, as well as a process for testing phlebotomical, surgical or orthopedic instrumentation or practicing phlebotomical, surgical or orthopedic procedures using the medical device containing the collagen-cellulose material. | 04-25-2013 |
20130109762 | SILK PARTICLES FOR CONTROLLED AND SUSTAINED DELIVERY OF COMPOUNDS | 05-02-2013 |
20130116342 | SALT-RESISTANT EMULSIONS - The invention relates to methods of modulating the stability of emulsions, especially the stability of emulsions to flocculation and coalescence. The use of peptide emulsifiers comprising at least one side chain carboxylate group in preparing emulsions that are stable to flocculation or coalescence in the presence of salt is also described. | 05-09-2013 |
20130150461 | PROCESS FOR PRODUCING PROTEIN MICROPARTICLES - The present invention relates to a process for producing protein microparticles in dilute organic acid solutions and in the absence of an alcohol such as ethanol. The microparticles are formed by dissolving a cereal prolamin protein in a concentrated organic acid solution with agitation and then diluting the solution with an aqueous solution. Protein microparticles having vacuoles are thus formed. The protein microparticles may be used to form powders, films, coatings, matrices, scaffolds and the like. Complete films can be formed from the protein microparticles of the invention. | 06-13-2013 |
20130158131 | SILK FIBROIN MATERIALS AND USE THEREOF - The present invention provides processes for producing porous silk fibroin scaffold material. The porous silk fibroin scaffold can be used for tissue engineering. The porosity of the silk fibroin scaffolds described herein can be adjusted as to mimic the gradient of densities found in natural tissue. Accordingly, methods for engineering of 3-dimensional tissue, e.g. bone and cartilage, using the silk fibroin scaffold material are also provided. | 06-20-2013 |
20130197102 | 3D MATRICES OF HUMAN ELASTIN-LIKE POLIPEPTIDES AND METHOD OF PREPARATION THEREOF - 3D matrices or hydrogels made of human elastin-like polypeptides and their preparation are described. Said matrices can be obtained by enzymatic cross-linking of such polypeptides and can be used in the biomedical and pharmaceutical fields as support the growth of cells, isolated or as multicellular association, both on the surface and inside the matrix. Said matrices can also deliver pharmacologically active molecules, which are incorporated and then released in a controlled manner. | 08-01-2013 |
20130237612 | LEUCINE BETA ROLL DOMAINS AND USES THEREOF - In one aspect, the invention relates to a peptide that forms a calcium-dependent hydrogel using a rationally engineered beta roll peptide. In the absence of calcium, the peptide is intrinsically disordered. Upon addition of calcium, the peptide forms a corkscrew-like structure. In one embodiment, one face of the beta roll is mutated to comprise leucine residues. In some embodiments, a leucine zipper forming helical domain to the engineered beta roll forms hydrogels by physical cross-linking in calcium rich environments. | 09-12-2013 |
20130281547 | Purified Amphiphilic Peptide Compositions and Uses Thereof - A plurality of amphiphilic peptide chains having alternating hydrophilic and hydrophobic amino acids, wherein the peptide contains at least 8 amino acids, are complementary and structurally compatible, and self-assemble into a beta-sheet macroscopic scaffold wherein peptide at least about 75% of the chains have the same sequence. | 10-24-2013 |
20130303631 | Environmentally Friendly and Aerated Topical Benefit Composition - Environmentally friendly and aerated topical benefit compositions are described. The compositions are emulsified with hydrophobin and upon topical application deliver excellent sensory and absorption characteristics along with consumer desirable drying times. | 11-14-2013 |
20130331465 | FLUORINATED PROTEIN-BASED POLYMERIC CARRIERS - A biologically derived polymer that facilitates the solubilization and protection of small molecules for use in drug delivery, in which the polymer is a protein polymer. A biologically derived polymer that facilitates the solubilization and protection of small molecules for use in drug delivery, incorporating fluorinated amino acids into the protein polymer for visualization and detection by | 12-12-2013 |
20130345321 | GENIPIN CROSS-LINKED FIBRIN GELS - The invention provides a genipin cross-linked fibrin gel. The ratio of genipin to fibrin in the gel ranges from about 0.1:1 to about 10:1 (genipin:fibrin). The gel can be hydrogel. The gel further contains proteins from the extracellular matrix that promote cell growth and density in and around the gel. Also provided is method for repairing tissue defects by administering the gel to site of tissue defect. | 12-26-2013 |
20140011891 | MODIFICATIONS OF SOLID 3-sn-PHOSPHOGLYCERIDES - Methods for hydrolyzing solid ungranulated lysophosphatidylcholine with phospholipase A | 01-09-2014 |
20140045950 | DRUG DELIVERY VEHICLE - The invention provide herein provides for a targeted drug delivery vehicle compositions, methods of manufacture, and methods of treatment for therapeutic applications. | 02-13-2014 |
20140045951 | SYNTHETIC VITREOUS MATERIAL - A synthetic vitreous material contains a self-assembling peptide and a salt, and has an osmotic pressure of 40 mOsm/kg to 200 mOsm/kg. Such a synthetic vitreous material is not toxic to ocular tissue, is capable of maintaining an intraocular tamponade effect over a long term, and is easy to handle and inject into an eye of a patient. | 02-13-2014 |
20140057999 | PROTECTIVE, HYDROCOLLOID FOR ACTIVE INGREDIENTS - (Modified) rice endosperm protein is used as novel protective hydrocolloid for active ingredients, especially fat-soluble active ingredients and/or colorants. Included are compositions comprising (modified) rice endosperm protein and at least one active ingredient and to their manufacture, as well as to the (modified) rice endosperm protein itself and its manufacture. These compositions are used for the enrichment, fortification and/or coloration of food, beverages, animal feed, personal care or pharmaceutical compositions, and to food, beverages, animal feed, personal care and pharmaceutical compositions containing such a (modified) rice endosperm protein and such a composition, respectively. | 02-27-2014 |
20140080922 | Polypeptide Based Block Copolymer and the Process for the Preparation Thereof, and the Polymer Micelles Using the Same - A polypeptide based block copolymer having biodegradability due to peptidase, a process for the preparation thereof, and polymer micelles using the same are provided. The block copolymer is a block copolymer of a polyethylene glycol-based compound having properties such that the solubility for water is different depending on the pH, but cannot form micelles due to a self-assembly phenomenon; and a polyglutamic acid-based compound formed using an aminolysis reaction of glutamic acid and tertiary amine in which the end of one alkyl group is substituted with NH | 03-20-2014 |
20140113976 | PRODUCTION METHOD OF COSMETIC, PREPARATION METHOD OF GEL FOR COSMETICS, AND METHOD OF REDUCING USE AMOUNT OF POLYMER THICKENER BLENDED IN COSMETIC RAW MATERIALS - A production method of a cosmetic that includes blending at least one lipid peptide-type gelator that contains a low-molecular lipid peptide or a pharmaceutically usable salt thereof at a ratio of 0.1% by weight to 0.5% by weight based on a mass of the polymer thickener to form a thickening gel; a preparation method of a gel for cosmetics that includes blending, into an aqueous medium for cosmetics, a polymer thickener and at least one lipid peptide-type gelator that contains a low-molecular lipid peptide or a pharmaceutically usable salt thereof at the above-mentioned ratio to form a gel; and a method of reducing the use amount of a polymer thickener in production of a cosmetic that includes blending at least one lipid peptide-type gelator that contains a low-molecular lipid peptide or a pharmaceutically usable salt thereof at the above-mentioned ratio. | 04-24-2014 |
20140142200 | Keratoprosthesis - The invention comprises a method of making molded, double-crosslinked (i.e., two stages of crosslinking), transparent, collagen materials using a novel combination of diafiltration, lyophilization, and homogenization. The collagen material can be used not only as an ophthalmic device, but also as a tissue scaffold, drug delivery device, wound dressing, or other collagen hydrogel based device. | 05-22-2014 |
20140155496 | Templated Native Silk Smectic Gels - One aspect of the present invention relates to a method of preparing a fibrous protein smectic hydrogel by way of a solvent templating process, comprising the steps of pouring an aqueous fibrous protein solution into a container comprising a solvent that is not miscible with water; sealing the container and allowing it to age at about room temperature; and collecting the resulting fibrous protein smectic hydrogel and allowing it to dry. Another aspect of the present invention relates to a method of obtaining predominantly one enantiomer from a racemic mixture, comprising the steps of pouring an aqueous fibrous protein solution into a container comprising a solvent that is not miscible with water; sealing the container and allowing it to age at about room temperature; allowing the enantiomers of racemic mixture to diffuse selectively into the smectic hydrogel in solution; removing the smectic hydrogel from the solution; rinsing predominantly one enantiomer from the surface of the smectic hydrogel; and extracting predominantly one enantiomer from the interior of the smectic hydrogel. The present invention also relates to a smectic hydrogel prepared according to an aforementioned method. | 06-05-2014 |
20140187651 | MULTI-HIERARCHICAL SELF-ASSEMBLY OF A COLLAGEN MIMETIC PEPTIDE - The present disclosure generally relates to collagen, and more particularly compositions and methods related to collagen-mimetic peptides. More specifically, the present disclosure provides a collagen-mimetic peptide and peptide systems comprising the amino acid sequence (Pro-Lys-Gly) | 07-03-2014 |
20140206774 | POLYSACCHARIDE AND PROTEIN-POLYSACCHARIDE CROSS-LINKED HYDROGELS FOR SOFT TISSUE AUGMENTATION - Disclosed herein are cohesive soft tissue fillers, for example, dermal and subdermal fillers, based on hyaluronic acids and optionally including proteins. In one aspect, hyaluronic acid-based compositions described herein include zero-length cross-linked moieties and optionally at least one active agent. The present hyaluronic acid-based compositions have enhanced flow characteristics, hardness, and persistence compared to known hyaluronic acid-based compositions. Methods and processes of preparing such hyaluronic acid-based compositions are also provided. | 07-24-2014 |
20140213663 | ICE CRYSTALLIZATION INHIBITOR DERIVED FROM PLANT SEED - The objective to be solved by the present invention is to provide a novel ice crystallization inhibitor which is industrially useful, which can be efficiently and stably produced in a safe process suitable for a food production without difficulty and which has excellent functions and properties. Also, the objective of the present invention is to provide an antibody which specifically reacts with the ice crystallization inhibitor, and a composition, a food, a biological sample protectant and a cosmetic which contain the ice crystallization inhibitor. Furthermore, the objective of the present invention is to provide a peptide which gives an indication of a protein having an ice crystallization inhibitory activity. The ice crystallization inhibitor according to the present invention is characterized in comprising a seed protein derived from a plant belonging to genus | 07-31-2014 |
20140275290 | ECM IMPLANT COMPOSITIONS AND METHODS - Described our medical compositions and methods including a particulate extracellular matrix tissue in admixture with sugar. Such medical compositions, in dried forms, can demonstrate enhanced rehydration properties. Medical compositions and products as described herein find particular use in treating diseased and/or damaged tissue, such as wound repair. Related methods of manufacture and use are also described. | 09-18-2014 |
20140288192 | DYNAMIC BIO-NANOPARTICLE PLATFORMS - The invention in suitable embodiments is directed to dynamic bio-nanoparticle elements and bio-nanoparticle platforms employing such bio-nanoparticle elements. In one aspect, one or more elements of one or more types, formed from isolated, synthetic and or recombinant amino acid residues comprising in whole or in part one or more types of Clathrin and or Coatomer I/II proteins of one or more isoforms, execute one or more functions and or effect one or more ends, in vivo and or in vitro. | 09-25-2014 |
20140288193 | METHOD FOR THE SIMULTANEOUS PRODUCTION OF ETHANOL AND A FERMENTED, SOLID PRODUCT - The invention relates to a method for the simultaneous production of a fermented, solid product and ethanol comprising the following steps: 1) providing a mixture of milled or flaked or otherwise disintegrated biomass, comprising oligosaccharides and/or polysaccharides and live yeast in a dry matter ratio of from 2:1 to 100:1, and water; 2) fermenting the mixture resulting from step (1) under conditions where the water content in the initial mixture does not exceed 65% by weight, for 1-36 hours at a temperature of about 25-60° C. under anaerobic conditions; 3) incubating the fermented mixture resulting from step (2) for 0.5-240 minutes at a temperature of about 70-150° C.; and 4) separating wet fermented, solid product from the fermented mixture resulting from step (3); further comprising either a) that the fermentation in step (2) is performed in one or more interconnected paddle worm or continuous worm conveyers with inlet means for the fermentation mixture and additives and outlet means for the ferment as well as control means for rotation speed, temperature and pH, or b) that one or more processing aids are added in any of steps (1), (2) and (3) and further comprising a step of 5) separating crude ethanol from the fermented mixture in step (2) by vacuum and/or in step (3) by vacuum or by injection of steam and condensing the surplus stripping steam. The invention further relates to the products of this method as well as uses thereof. | 09-25-2014 |
20140329914 | Amphiphilic Peptides for Thoracic Air Leakage Occlusion - Provided are compounds and methods useful for sealing air leaks in the thoracic cavity. Compounds and compositions of the invention comprise certain amphiphilic peptides, 8-200 amino acid residues long, that self-assemble spontaneously to form a gel in the presence of physiological pH and/or in the presence of a cation. In one embodiment, the peptide comprises a repeated sequence arginine-alanine-aspartic acid-alanine (RADA). Methods of the invention include a method of occluding a pulmonary air leak in a subject, comprising applying a compound of the invention to the site of a pulmonary air leak. The compounds and methods of the invention can be combined with other agents useful to treat cancer, inflammation, or infection. | 11-06-2014 |
20140378555 | FACIAL TREATMENT DEVICE - Embodiments of the present disclosure are directed to portable facial treatment devices, and methods of using same. In some embodiments, the invention is directed to a muscle toning treatment device, comprising: (i) a polarity generator; (ii) a single active electrode assembly comprising a first electrode being adapted to apply electrical current to the area of the skin to be treated; (iii) at least one vibration modality, wherein the vibration modality provides a vibration frequency, of between 5-6 MHz or between 30-35 Hz; (iv) at least one heating modality for heating the skin of the user, wherein the temperature of the heating modality is between 34 and 45 degrees Celsius; and (v) a counter electrode assembly comprising second electrode being adapted to be in continuous contact to a second location of the skin of the user. | 12-25-2014 |
20150011659 | LOW PROTEIN PERCENTAGE GELLING COMPOSITIONS - Described herein are low protein concentration gelling compositions comprising keratin proteins. | 01-08-2015 |
20150141524 | METHOD FOR THE MANUFACTURE OF BIO-PRODUCTS WITH A MODIFIED SUGAR PROFILE - The invention relates to a method for the production of a solid bio-product wherein at least 80% of the original indigestible oligosaccharide (raffmose, stachyose and verbascose) content has been degraded into digestible mono- and disaccharides, comprising the following steps: 1) providing a mixture of milled or flaked or otherwise disintegrated biomass, comprising oligosaccharides and optionally polysaccharides and further comprising proteinaceous plant parts, water and one or more enzyme preparations containing α-galactosidase(s); 2) reacting the mixture resulting from step (1) under continuous mixing and under conditions where the water content in the initial mixture does not exceed 65% by weight, for 0.15-36 hours at a temperature of about 20-65° C.; 3) incubating the reacted mixture from step (2) at a temperature and in a time period which inactivate said α-galactosidase(s), as well as solid bio-products obtainable by such method. The invention further relates to uses of the bio-product and a food, a feed, a cosmetic or pharmaceutical product or a nutritional supplement containing the solid bio-product. | 05-21-2015 |
20150290329 | Hetero-assembling, Tunable, and Injectable Hydrogels for Cell Encapsulation - A viscoelastic hydrogel based on a protein hetero-assembled with a polymer is provided. The protein cannot self-assemble with itself and the polymer cannot self-assemble with itself. The protein has a first association sequence (1stA) and a first spacer (1stSp). The polymer has a second association sequence (2ndA) and a second spacer (2ndSp). The first association sequence and the second association sequence are physically cross-linked to interact with each other with a 1:1 known and specific stoichiometry to form a three dimensional scaffold. The protein is represented by {1stA(1stSp)} | 10-15-2015 |
20150306229 | MALLEABLE HYDROGEL HYBRIDS MADE OF SELF-ASSEMBLED PEPTIDES AND BIOCOMPATIBLE POLYMERS AND USES THEREOF - Hybrid hydrogels formed of a plurality of peptides that are capable of self-assembling into a hydrogel in an aqueous solution and a biocompatible polymer that is characterized by high swelling capability, high elasticity and low mechanical strength are disclosed, with exemplary hybrid hydrogels being formed of a plurality of aromatic dipeptides and hyaluronic acid. The hybrid hydrogels are characterized by controllable mechanical and biological properties which can be adjusted by controlling the concentration ratio of the peptides and the polymer, and which average the mechanical and biological properties of the peptides and the polymer. Processes of preparing the hydrogels and uses thereof in pharmaceutical, cosmetic or cosmeceutic applications such as tissue engineering and/or regeneration are further disclosed. | 10-29-2015 |
20150320908 | BUILDING STRATIFIED BIOMIMETIC TISSUES AND ORGANS USING CROSSLINKED ULTRASHORT PEPTIDE HYDROGEL MEMBRANES - The present invention relates to hydrogel membranes comprising a hydrogel, said hydrogel comprising a plurality of tetramer amphiphilic peptides and/or peptoids capable of self-assembling into three-dimensional macromolecular nanofibrous networks, which entrap water and form said hydrogels, wherein at least a portion of said plurality of tetramer amphiphilic peptides and/or peptoids is chemically cross-linked. The present invention further relates to stratisfied biostructures and devices comprising at least two hydrogel membranes of the invention, which can be used e.g. to rebuild human skin and for tissue engineering of organs and tissues. The present invention further relates to corneal implants and devices comprising a hydrogel membrane of the invention. | 11-12-2015 |
20150328322 | DRUG DELIVERY VEHICLES - Embodiments are directed to compositions and methods related to delivery of drugs via a capsid shell. | 11-19-2015 |
20150361144 | POLYPEPTIDE POROUS BODY AND METHOD FOR PRODUCING SAME - A polypeptide porous body of the present invention is a porous body of a polypeptide derived from spider silk proteins. The polypeptide includes a water-insoluble polypeptide. The polypeptide porous body has an apparent density of 0.1 g/cm | 12-17-2015 |
20160009763 | PEPTIDE MOLECULAR MATERIALS | 01-14-2016 |
20160038635 | FILLER COMPOSITION FOR THE TREATMENT OF LIPOATROPHY - The present invention refers to a composition that is useful as a filler for the correction of soft tissue volume loss, for example for the cosmetic treatment of wrinkles, or for the treatment of disorders such as lipoatrophy or lipodystrophy in general, said composition comprising agarose and hyaluronic acid, or a pharmaceutically acceptable salt thereof. The particular interaction that takes place between the two components makes even high concentrations of agarose injectable and tolerable, said high concentrations being particularly useful for ensuring the duration and stability over time of the aesthetic results that are achievable using this filler. | 02-11-2016 |
20160060309 | ISOLATED CLATHRIN THERAPEUTICS - The invention in suitable embodiments is directed to purified clathrin protein therapeutics. In one aspect, one or more purified clathrin protein therapeutic, formed in whole or in part from isolated, synthetic and or recombinant amino acid residues comprising in whole or in part one or more clathrin heavy chain protein and isoforms thereof, forms one or one or more type of therapeutic agent for treating a disease, condition, or disorder comprising a cell element or a cell process in vivo or in vitro. | 03-03-2016 |
20160129119 | DISPERSION AND METHOD FOR FORMING HYDROGEL - An object is to provide dispersion containing lipid peptide type compound useful as low molecular weight gelator, such as lipid dipeptide and lipid tripeptide, and dissolution accelerator capable of dissolving the lipid peptide type compound at lower temperature and more easily. It is also an object to provide dispersion that can form hydrogel by simpler method and under milder condition (low temperature) and from which gel can be obtained as gel having high thermal stability, and provide method for forming the gel. Dispersion including: a lipid peptide type compound in which peptide portion formed by repetition of at least two or more identical or different amino acids is bonded to lipid portion including C | 05-12-2016 |
20160137704 | MODIFIED BIOTIN, MUTANT STREPTAVIDIN, AND USE THEREOF - It is an object of the present invention to provide a mutant streptavidin with a reduced affinity for natural biotin, and also to provide a modified biotin having a high affinity for the mutant streptavidin with a reduced affinity for natural biotin. According to the present invention, there is provided a reagent kit for use in treatments or diagnoses, which comprises: (a) a mutant streptavidin with a reduced affinity for natural biotin or biocytin; and a modified biotin having a high affinity for the above-described mutant streptavidin. | 05-19-2016 |
20160158366 | CLATHRIN THERAPEUTIC FOR AUTOIMMUNE DISEASES - The invention in suitable embodiments is directed to purified clathrin protein therapeutics. In one aspect, one or more purified clathrin protein therapeutic, formed in whole or in part from isolated, synthetic and or recombinant amino acid residues comprising in whole or in part one or more clathrin heavy chain protein and isoforms thereof, forms one or more type of therapeutic agent for treating an autoimmune disease, condition, or disorder in vivo or in vitro. | 06-09-2016 |
20160158367 | CLATHRIN THERAPEUTIC FOR NEUROLOGICAL DISEASES - The invention in suitable embodiments is directed to purified clathrin protein therapeutics. In one aspect, one or more purified clathrin protein therapeutic, formed in whole or in part from isolated, synthetic and or recombinant amino acid residues comprising in whole or in part one or more clathrin heavy chain protein and isoforms thereof, forms one or more type of therapeutic agent for treating a neurological disease, condition, or disorder in vivo or in vitro. | 06-09-2016 |
20180021250 | TRANSDERMALLY ABSORBABLE BASE MATERIAL CONTAINING LIPID PEPTIDE COMPOUND | 01-25-2018 |