Entries |
Document | Title | Date |
20080234391 | Synthesis of Reversible Shell Crosslinked Nanostructures - In one aspect, the present invention is directed to a thermally responsive AB diblock copolymer prepared by RAFT polymerization wherein the diblock copolymer comprises poly(N-(3-aminopropyl)methacrylamide hydrochloride)-block-(N-isopropylacrylamide). Nanostructures of the thermally responsive diblock copolymer are formed by molecularly dissolving the diblock copolymer in aqueous solution at room temperature; and increasing the solution temperature to form nanostructures, for example vesicles or micelles. The first RAFT polymerization of an unprotected amino acid based monomer directly in water is also disclosed. The present invention also provides a method of forming shell cross-linked vesicles by adding a RAFT synthesized anionic homopolymer to a solution of the thermally responsive diblock copolymer. A method of forming interpolyelectrolyte complexed micelles or vesicles is also disclosed, the method comprising preparing by sequential aqueous RAFT polymerization a block copolymer comprised of N,N,-dimethyl acrylamide (DMA), N-acryloyl alanine (AAL) and N-isopropyl acrylamide (NIPAM); dissolving the block copolymers into aqueous solution; raising the solution temperature above the lower critical solution temperature of the NIPAM block; allowing the micelle solution to equilibrate; adjusting the pH of the solution to about 5; adding a cationic polymer to the solution; and stirring the solution. The reaction is readily reversed by the addition of a salt solution. In another aspect of the invention a reversible shell cross-linked micelle of a triblock copolymer cross-linked with cystamine is disclosed where a cleaving agent can be added to cleave the micelles. The reaction can be reversed with the addition of tris(2-carboxyethyl)phosphine or dithiothreitol. | 09-25-2008 |
20080275137 | LOTION COMPOSITION FOR PERSONAL USE - This invention relates to emulsion compositions that can warm on contact with ambient moisture and can be used as lubricants on the skin of a person. They may be formulated in the form of a lotion and maintain stability for a significant period of time. | 11-06-2008 |
20080280998 | Bifunctional Derivatives of Polyethylene Glycol, Their Preparation and Use - The patent describes homo- or hetero-bifunctional derivatives of polyethylene glycol (PEG) obtained by selectively modifying the hydroxyl end groups of commercial PEGs of different molecular weights with reactive bifunctional molecules. The synthesis process comprises steps involving sequential derivatization of PEG terminal hydroxyl groups with a bifunctional compound, purification of the bifunctional PEG obtained and/or protection of its functional groups with possible selective removal of terminal protections. The bifunctional PEGs (biPEG) obtained are usable as carriers and/or stabilizers for substances used for diagnostic, prophylactic and therapeutic purposes, conjugated to the same biocompatible biPEG support. The bifunctionalized PEG derivatives can also be used in supported synthesis processes. | 11-13-2008 |
20080300320 | Use of Polyvinyl Lactam-Polyalkylene Block Copolymers as Solubilisers for Poorly Water-Soluble Compounds - Use of polyvinyllactam-polyalkylene oxide block copolymers as solubilizers for sub-stances which are sparingly soluble in water. | 12-04-2008 |
20080319091 | Polymer Derivatives Comprising an Imide Branching Point - The invention provides a water-soluble polymer comprising (i) an imide group comprising a linking nitrogen atom, a first carbonyl group covalently attached to the linking nitrogen atom, and a second carbonyl group covalently attached to the linking nitrogen atom; (ii) a first water-soluble polymer segment covalently attached, either directly or through one or more atoms, to the first carbonyl group of the imide group and (iii) a second water-soluble polymer segment covalently attached, either directly or through one or more atoms, to the second carbonyl group of the imide group. The invention also provides, among other things, methods for preparing polymers, conjugates, pharmaceutical compositions and the like. | 12-25-2008 |
20090036549 | SUBSTANCE-ENCAPSULATED CARBON NANOHORN COMPLEX AND PRODUCING METHOD THEREOF - A cap of polyamine molecules is provided on an aperture portion of carbon nanohorns having apertures formed by oxidation. The polyamine cap opens and closes according to the pH of the ambient environment, thereby controlling release of an encapsulation substance. | 02-05-2009 |
20090105351 | MICELLAR DRUG DELIVERY SYSTEMS FOR HYDROPHOBIC DRUGS - This invention provides compositions comprising a hydrophobic drug, a biocompatible micelle forming polymer, and a biocompatible low molecular weight, water-soluble polymer. Also provided are devices for injection of such compositions and for the use of such compositions to form hydrophobic drug containing micelles within the body of a patient. | 04-23-2009 |
20090124706 | CONTACT LENS SOLUTION AND METHOD FOR HYDROPHILIZING CONTACT LENS BY USING THE SAME - It is an object of the present invention to provide a contact lens solution that imparts stable hydrophilicity even to a surface of a contact lens having strong water repellency. There was prepared a contact lens solution comprising a copolymer of N-p-vinylbenzyl-D-lactonamide and at least one monomer copolymerizable therewith. The copolymer is present in the solution in an amount of 0.0001 to 5 w/v %. | 05-14-2009 |
20090209658 | Embolic compositions - Embolic compositions comprising macromers having a backbone comprising a polymeric backbone comprising units with a 1,2-diol or 1,3-diol structure, such as polyvinyl alcohol, and pendant chains bearing crosslinkable groups and, optionally, other modifiers. When crosslinked, the macromers form hydrogels having many properties advantageous for use as embolic agents to block and fill lumens and spaces. The embolic compositions can be used as liquid embolic agents and crosslinked in situ or as preformed embolic articles, such as microspheres. | 08-20-2009 |
20090258952 | Patch containing anti-inflammatory agent - An anti-inflammatory-containing plaster is provided. The anti-inflammatory-containing plaster may include, e.g., a styrene-isoprene-styrene block copolymer, a high molecular weight polyisobutylene, a low molecular weight polyisobutylene, a tackifier, a plasticizer, a dispersant, and an anti-inflammatory having a carboxyl group or a salt thereof. However, the anti-inflammatory-containing plaster does not contain L-menthol. The anti-inflammatory-containing plaster has medicament release rates of 20-64% by mass and 40-93% by mass at one hour and three hours, respectively. | 10-15-2009 |
20090264537 | BIODEGRADABLE BLOCK COPOLYMERIC COMPOSITIONS FOR DRUG DELIVERY - An improved drug delivery composition and method of use is disclosed. The composition comprises one or more biodegradable block copolymer drug carriers; and a reconstitution enhancing and enabling agent comprising polyethylene glycol (PEG), a PEG derivative or a mixture of PEG and a PEG derivative. The composition can be administered as is or after being be dissolved or rapidly reconstituted in an aqueous vehicle to afford a homogeneous solution or uniform colloidal systems. | 10-22-2009 |
20090306225 | AURIS FORMULATIONS FOR TREATING OTIC DISEASES AND CONDITIONS - Disclosed herein are compositions and methods for the treatment of otic disorders with immunomodulating agents and auris pressure modulators. In these methods, the auris compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of the immunomodulating and/or auris pressure modulating compositions and formulations onto the auris media and/or auris interna target areas, or via perfusion into the auris media and/or auris interna structures. | 12-10-2009 |
20100010102 | TRIGGERED RELEASE OF DRUGS FROM POLYMER PARTICLES - The present invention includes compositions and methods for the controlled delivery of active agents, e.g., drugs, based on one or more release triggers found in the environment in which the active agent-loaded particle is located. The composition and methods include a polymer network having a polymer cross-linked by peptides that include one or more proteolytic cleavage sites. | 01-14-2010 |
20100010103 | POLYMER ENCAPSULATION AND/OR BINDING - Encapsulation of and binding to pegylated bioactive molecules via functionalized comb, block, branched type polymers formed by nitroxide mediated controlled radical polymerization is disclosed. | 01-14-2010 |
20100016450 | CONTROLLED RELEASE DELIVERY DEVICES FOR THE TREATMENT OF OTIC DISORDERS - Disclosed herein are delivery devices for use in the treatment of otic disorders wherein the delivery device is administered locally to an individual afflicted with an otic disorder, through direct application or via perfusion into the targeted auris structure(s). | 01-21-2010 |
20100022661 | CONTROLLED RELEASE COMPOSITIONS FOR MODULATING FREE-RADICAL INDUCED DAMAGE AND METHODS OF USE THEREOF - Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with free-radical modulating agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s). | 01-28-2010 |
20100036000 | CONTROLLED RELEASE ANTIMICROBIAL COMPOSITIONS AND METHODS FOR THE TREATMENT OF OTIC DISORDERS - Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with antimicrobial agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s). | 02-11-2010 |
20100048734 | HYDROPHILIC COPOLYMERS AND ASSEMBLIES CONTAINING THE SAME - A water soluble copolymer includes first and second hydrophilic block segments or graft chains. The first hydrophilic block segment or graft chain contains cyclodextrin groups in at least a majority of its repeating units, and the second hydrophilic block segment or graft chain contains repeating units other than cyclodextrin groups. The first and second block segments or graft chains are covalently linked. | 02-25-2010 |
20100048735 | POLYAMINOACIDS FUNCTIONALIZED WTIH ALPHA-TOCOPHEROL, AND USES THEREOF, ESPECIALLY THERAPEUTIC USES - The invention concerns novel biodegradable polyaminoacid materials, useful in particular for vectoring active principles(s). The invention also concerns novel pharmaceutical, cosmetic dietetic or phytosanitary compositions based on said polyaminoacids. The invention aims at providing a novel polymer raw material, capable of being used for vectoring active principles and enabling optimal fulfillment of all specified requirements: biocompatibility, biodegradability, easy and inexpensive transformation into particles vectoring active principles, said particles being themselves capable of forming colloidal suspensions, of being easily associated with numerous active principles, and of releasing said active principles in vivo. Therefor, the present invention concerns first of all amphiphilic polyaminoacids comprising aspartic acid units and/or glutamic acid units, characterized in that at least part of said units carry grafts, including at least one alphα-tocopherol motif, for example (polyglutamate or polyaspartate grafted with alphα-tocopherol of synthetic or natural origin). | 02-25-2010 |
20100063165 | Polyamide-Polyether Block Copolymer - Copolymers having linked internal polyether blocks and internal polyamide blocks have advantageous physical properties and solvent-gelling abilities. The copolymer may be prepared from a reaction mixture that contains 1,4-cyclohexane dicarboxylic acid (CHDA) and poly(alkyleneoxy) diamine (PAODA). Optionally, the reaction mixture contains no monofunctional compound reactive with either amine or carboxylic acid groups, however some of this monofunctional compound may be present. Dimer diamine and/or dimer acid may be present in the reaction mixture. A copolymer may also be prepared from a reaction mixture containing dimer acid and at least two diamine compound(s) including PAODA and short-chain aliphatic diamine having 2-6 carbons (SDA), wherein: a) the reaction mixture comprises x grams of PAODA and y grams of SDA, and x/(x+y) is 0.8-0.98; b) the reaction mixture weighs z grams, and x/z is at least 0.25; and c) the reaction mixture contains either no co-diacid, or comprises a small amount of co-diacid, wherein, if the reaction mixture comprises a small amount of co-diacid, then acid equivalents from co-diacid contribute less than 25% of the total acid equivalents present in the reaction mixture. | 03-11-2010 |
20100120923 | ADHESIVE COMPLEX COACERVATES AND METHODS OF MAKING AND USING THEREOF - Described herein is the synthesis of adhesive complex coacervates and their use thereof. The adhesive complex coacervates are composed of a mixture of one or more polycations and one or more polyanions. The polycations and polyanions in the adhesive complex coacervate are crosslinked with one another by covalent bonds upon curing. The adhesive complex coacervates have several desirable features when compared to conventional bioadhesives, which are effective in water-based applications. The adhesive complex coacervates described herein exhibit good interfacial tension in water when applied to a substrate (i.e., they spread over the interface rather than being beaded up). Additionally, the ability of the complex coacervate to crosslink intermolecularly increases the cohesive strength of the adhesive complex coacervate. The adhesive complex coacervates have numerous biological applications as bioadhesives and drug delivery devices. In particular, the adhesive complex coacervates described herein are particularly useful in underwater applications and situations where water is present such as, for example, physiological conditions. | 05-13-2010 |
20100137452 | AQUEOUS COMPOSITIONS HAVING PROTECTED HYDROPHILIC ACTIVES - Aqueous compositions comprising hydrophilic actives and block copolymers comprising at least one block of copolymerized ethylene oxide and at least one block of a polymerized alkylene oxide, the alkylene comprising at least 4 carbon atoms, are described, along with methods of stabilizing hydrophilic actives and methods of increasing compatibility among hydrophilic actives. | 06-03-2010 |
20100144898 | MIXTURE COMPRISING AN ALKYLPOLYGLUCOSIDE, A COSURFACTANT AND A POLYMER ADDITIVE - A mixture comprising a component I comprising 80-20% by weight of a first surfactant component I | 06-10-2010 |
20100144899 | METHOD FOR PREPARING NANO-EMULSIONS - The present invention relates to a method for preparing nano-emulsions comprising at least one aqueous continuous phase and at least one oily dispersed phase, comprising the steps of:
| 06-10-2010 |
20100190870 | POLYMER COMPRISING WATER SOLUBLE UNITS AND LCST UNITS, AND AQUEOUS COMPOSITION COMPRISING SAME - The invention concerns a polymer comprising water soluble units and LCST units consisting of ethylene oxide and propylene oxide random copolymers, or one of its salts. The invention also concerns an aqueous composition in particular thickened, even gelled, comprising such a polymer or one of its salts and an aqueous phase. | 07-29-2010 |
20100197805 | COMPOSITION FOR IMPROVING THE SURFACE APPEARANCE OF THE SKIN - The present invention relates to a cosmetic composition in the form of a paste, containing, in a physiologically acceptable medium, at least 10% by weight, relative to its total weight, of filler(s), at least one silicone polyamide block copolymer (PSPA) and at least one wax having a starting melting point of greater than or equal to 50° C. The present invention also relates to a cosmetic treatment method for improving the surface appearance of the skin, and in particular for reducing the visible and/or tactile irregularities of the skin, for instance the cutaneous microrelief, comprising at least the application of at least one composition as defined above to skin exhibiting said irregularities. | 08-05-2010 |
20100197806 | Method Involving 1-Benzotriazolyl Carbonate Esters of Polymers - The invention provides a method comprising the steps of (i) reacting a water-soluble and non-peptidic polymer having two or more terminal hydroxyl groups with di(1-benzotriazolyl)carbonate to form a water-soluble and non-peptidic polymer having two or more 1-benzotriazolylcarbonate ester groups; and (ii) reacting the water-soluble and non-peptidic polymer having two or more 1-benzotriazolylcarbonate ester groups with a water-soluble and non-peptidic polymer having three or more primary amino groups under conditions effective to form a cross-linked polymer composition. | 08-05-2010 |
20100261799 | STABLE AND COMPATIBLE POLYMER BLENDS - The present invention pertains to products and processes relating to compatible polymer blends comprising at least one sulfonated polymer and at least one non-sulfonated polymer. The sulfonated polymers may be produced using a number of sulfonating agents including a coordination complex of sulfur trioxide. The polymeric blended materials described herein are useful in a variety of applications, including as coatings for medical devices, protective clothing and fabric, laboratory equipment, vascular stents and shunts, absorbent materials and separation membranes, three-dimensional constructs, devices, and other uses. | 10-14-2010 |
20110015279 | SKIN CARE COMPOSITION - The invention relates to skin care compositions containing special polyurethanes for application to the skin. The invention also relates to the use of said polyurethanes for producing skin care products. | 01-20-2011 |
20110021642 | WATER-SOLUBLE ACRYLIC ACID SALT POLYMER AND GELLING BASE - An object of the present invention is to provide a water-soluble acrylate polymer that can form a gelling base. When used in forming a poultice or cooling sheet, the gelling base not only imparts desirable stretchability, but also has an appropriate reaction rate with a polyvalent metal. The gelling base is free from gel penetration to the back side of a support or gel seeping from the support while the gel is being cured, and is easily applied to the support. When the gelling base is gelated by being allowed to stand under the conditions of 25° C. and a relative humidity of 60%, the gel strength is 3,200 to 7,000 dyn/cm | 01-27-2011 |
20110039948 | Novel Polycarbonate-Polyorganosiloxane- And/Or Polyurethane-Polyorganosiloxane Compounds - The present invention relates to novel polycarbonate-polyorganosiloxane and/or polyurethane-polyorganosiloxane compounds, methods for their production, their use, functional formulations containing them, precursors for their production, as well as reactive compositions containing the aforementioned precursors. | 02-17-2011 |
20110098364 | NOVEL INVERSE LATICES BASED ON FATTY ALCOHOL ETHERS, AND COSMETIC, DERMOCOSMETIC, DERMOPHARMACEUTICAL OR PHARMACEUTICAL COMPOSITIONS COMPRISING - Novel inverse latices based on fatty alcohol ethers of formula R | 04-28-2011 |
20110118361 | NOVEL POLYMER PARTICLES AND USE THEREOF - Provided are polymer particles composed of a terminally branched copolymer represented by the following general formula (1) and having a number average molecular weight of not more than 2.5×10 | 05-19-2011 |
20110224309 | WHIPPED COMPOSITION FOR THE TREATMENT OF KERATIN FIBERS - A method for treating a keratinous substrate comprising contacting the keratinous substrate with a composition containing at least one emulsifying agent comprising at least two different polysaccharides and at least one nonionic surfactant; at least one gelling agent; optionally, at least one film former, and a cosmetically acceptable carrier; wherein the composition exhibits an enhanced elastic property and the composition possesses a whipped texture. | 09-15-2011 |
20110237686 | FORMULATIONS AND METHODS OF USE - The invention relates to the liquid and lyophilized formulations of small particulates, liposomes, and micelles, and methods for making and using the formulations. In particular, at least in some embodiments, the present invention relates to the production and lyophilization of PEGylated nanoparticles, microparticles, micelles, and liposomes for use and administration in to a subject. | 09-29-2011 |
20110288181 | PREPARATIONS OF BIOLOGICALLY ACTIVE SUBSTANCES WITH ENLARGED SURFACE BASED ON AMPHIPHILIC COPOLYMERS - Preparations with enlarged surface comprising an active ingredient and an amphiphilc copolymer, wherein the copolymer comprises at least one polyether-containing graft polymer. The preparations are partially or completely foamed. Processes for producing the preparations are also described, including processes comprising extrusion of a melt impregnated with a physiologically acceptable volatile blowing agent. | 11-24-2011 |
20120010302 | New Types of Polyester-Modified Organopolysiloxanes - The invention relates to new types of polyester-polysiloxane block copolymers, to processes for their preparation and to their use. | 01-12-2012 |
20120115962 | CYCLODEXTRIN-MODIFIED POLYAMINES FOR DELIVERY OF THERAPEUTIC MOLECULES - The present invention is directed to drug delivery vehicles comprising one or more cyclodextrin moieties conjugated to a dendritic polyamine for the delivery of small molecule and protein therapeutic molecules and nucleic acid therapeutic molecules, and methods of making and using the delivery vehicles. | 05-10-2012 |
20120157550 | DRUG CARRIERS COMPRISING AMPHILPHILIC BLOCK COPOLYMERS - An aqueous composition comprises an amphiphilic block copolymer, having a hydrophilic block comprising pendant zwitterionic groups and a hydrophobic block, and a biologically active compound associated with the polymer. The polymer is preferably in the form of micelles, and preferably the biological active is a hydrophobic drug. The hydrophilic block is preferably formed from acrylic monomer including phosphorylcholine groups. The hydrophobic group is suitably formed from monomer which has groups which can be ionised at useful pH's, especially tertiary amine groups. Micelles may be formed by dissolving the block copolymer in aqueous solvent at a pH at which the amine groups are protonated then raising the pH to a value at which the amine groups are substantially deprotonated, whereupon micelles spontaneously form. The preformed micelles are then contacted with active, under conditions such that solubilisation of the active occurs. The active may be for tumour treatment. | 06-21-2012 |
20120172454 | BIODEGRADABLE DRUG DELIVERY COMPOSITIONS - A biodegradable drug delivery compositions comprising a triblock copolymer containing a polyester and a polyethylene glycol and a diblock copolymer containing a polyester and an end-capped polyethylene glycol, as well as a pharmaceutically active principle is disclosed. | 07-05-2012 |
20120178824 | HYDROGELS BASED ON ESTERS OF POLYISOBUTENESUCCINIC ACID - The present invention relates to the use of esters of polyisobutenesuccinic acid for producing hydrogels, and to the use of such hydrogels for cleaners and care compositions for the home (so-called homecare products), for cosmetics, and also for medical products. | 07-12-2012 |
20120238640 | Polymer Derivatives Comprising an Imide Branching Point - The invention provides a water-soluble polymer comprising (i) an imide group comprising a linking nitrogen atom, a first carbonyl group covalently attached to the linking nitrogen atom, and a second carbonyl group covalently attached to the linking nitrogen atom; (ii) a first water-soluble polymer segment covalently attached, either directly or through one or more atoms, to the first carbonyl group of the imide group and (iii) a second water-soluble polymer segment covalently attached, either directly or through one or more atoms, to the second carbonyl group of the imide group. The invention also provides, among other things, methods for preparing polymers, conjugates, pharmaceutical compositions and the like. | 09-20-2012 |
20120238641 | DENDRITIC POLYUREA FOR SOLUBILIZING ACTIVE SUBSTANCES OF LOW SOLUBILITY - The present invention provides a composition comprising an amphiphile and an active ingredient whose solubility in water at 20° C. is not more than 10 g/L, wherein the amphiphile comprises a dendritic polyurea which is joined to at least one linear or comb-type polymer, and the joining is effected via a difunctional linker, if the repeat units of the linear polymer are composed of polymerized alkylene oxide. The invention also relates to an amphiphile comprising a dendritic polyurea and a process for preparing the amphiphile. | 09-20-2012 |
20120245233 | CROSSLINKED PIGMENT DISPERSION BASED ON STRUCTURED VINYL POLYMERIC DISPERSANTS - The present disclosure provides an aqueous dispersion comprising a solid particle and a structured vinyl polymeric dispersant, wherein said structured vinyl polymer dispersant comprises at least one hydrophilic segment and at least one hydrophobic segment, the hydrophilic segment comprising at least one crosslinkable moiety, wherein the crosslinkable moiety is cross-linked with a crosslinking agent that is substantially insoluble in the aqueous ink vehicle. | 09-27-2012 |
20120252905 | DRUG DELIVERY FROM RAPID GELLING POLYMER COMPOSITION - Compositions are disclosed that afford drug delivery from two-part polymer compositions that rapidly form covalent linkages when mixed together. Such compositions are particularly well suited for use in a variety of tissue related applications when rapid adhesion to the tissue and gel formation is desired along with drug delivery. For example, the compositions are useful as tissue sealants, in promoting hemostasis, in effecting tissue adhesion, in providing tissue augmentation, and in the prevention of surgical adhesions. | 10-04-2012 |
20120259021 | SELF-ASSEMBLED PARTICLES FROM ZWITTERIONIC POLYMERS AND RELATED METHODS - Zwitterionic block copolymers and zwitterionic conjugates that advantageously self-assemble into particles, particles assembled from the zwitterionic block copolymers and zwitterionic conjugates, pharmaceutical compositions that include the self-assembled particles, and methods for delivering therapeutic and diagnostic agents using the particles. | 10-11-2012 |
20120264830 | CHONDROITIN SULFATE-POLYCAPROLACTONE COPOLYMER, METHOD FOR PREPARING THE SAME AND APPLICATION THEREOF - A method for preparing a chondroitin sulfate-polycaprolactone copolymer includes subjecting a chondroitin sulfate component and a polycaprolactone polymer to an atom transfer radical polymerization reaction in the presence of a catalyst. | 10-18-2012 |
20120309850 | WOUND CARE DEVICE - A wearable article formed of a gelatinous elastomer composition having 100 parts by weight of triblock copolymer of the general configuration poly(styrene-ethylene-butylene-styrene) wherein the styrene end block to ethylene and butylene center block ratio is within the range of from between 31:69 to 40:60, from about 300 to about 1,600 parts by weight of a plasticizing oil and having a gel rigidity of about 20 gram to about 700 gram Bloom. | 12-06-2012 |
20120322894 | Direct Compression Polymer Tablet Core - The present invention provides a tablet core which comprises at least about 95% by weight of an aliphatic amine polymer. The invention also provides a method of producing a tablet core comprising at least about 95% by weight of an aliphatic amine polymer resin. The method comprises the step of compressing the aliphatic amine polymer to form the tablet core. The tablet core can further include one or more excipients. | 12-20-2012 |
20120322895 | BIODEGRADABLE POLYMERIC NETWORKS AND METHODS FOR MANUFACTURING THE SAME - Methods of manufacturing a three-dimensional, biodegradable, thermoset polymeric network composition having desirable degradation and mechanical properties, comprising a macromer component cross-linked with a monofunctional acrylate-containing component. The macromer component can comprise a diacrylate-containing component polymerized with an amine-containing component, wherein the molar ratio of the diacrylate-containing component to the amine-containing component is greater than or equal to 1. | 12-20-2012 |
20120329882 | pH Responsive Self-Heating Hydrogels Formed By Boronate-Catechol Complexation - Biocompatible hydrogels made from cross-linked catechol-borate ester polymers are disclosed, along with methods of synthesizing and using such hydrogels. The hydrogels of the present invention are prepared by boronic acid-catechol complexation between catechol-containing macromonomers and boronic acid-containing cross-linkers. The resulting hydrogels are pH-responsive and self-healing, and can be used in a number of different biomedical applications, including in surgical implants, in surgical adhesives, and in drug delivery systems is data provides further evidence of the viability of using the disclosed hydrogels for in vivo in biomedical applications. | 12-27-2012 |
20130035401 | NOVEL SELF-REVERSIBLE REVERSE LATEX, AND USE THEREOF AS A THICKENING AGENT IN A COSMETIC COMPOSITION - A self-reversible reverse latex, and its use as a thickener. The self-reversible reverse latex includes: 50%-70% of a cross-linked polyelectrolyte obtained by the polymerization of a monomer of formula (I), with R1 being 8 to 20 carbon atoms and 1≦n≦30 for a neutral monomer, and a monomer having an acid function; 4%-10% of a water-in-oil emulsifier; 1%-10% of an oil-in-water emulsifier including a surface-active composition (C); 15%-45% oil; and 0%-5% water. Composition (C) is 10%-50% composition (C | 02-07-2013 |
20130035402 | BIOABSORBABLE POLYESTERAMIDES AND USES THEREOF - Novel biodegradable polyesteramides derived from optionally functionalized diacids and optionally functionalized diamines or from compounds having both optionally functionalized acid and optionally functionalized amine moieties, their preparation, and absorbable surgical articles fabricated therefrom, such as monofilament and multifilament sutures, films, sheets, plates, clips, staples, pins, screws, stents, stent coatings, packaging materials, and other implantable surgical devices, and the like, are described herein. | 02-07-2013 |
20130059925 | Biodegradable Polymeric Hydrogel Composition - A biodegradable polymeric hydrogel composition including a component A and component B forming a β-aminoester linkage such that the linkage results in gelation, wherein component A is water soluble polymer containing acrylate functionality and component B is a water soluble amine functionality useful for medical applications such as such as drug delivery, tissue engineering, and biomaterials and method of preparation thereof. | 03-07-2013 |
20130072575 | Method and Composition for Treating Pain - Presented are methods of using topical analgesic compositions for rapid relief of muscular aches and pain where the analgesic composition has been stored at a temperature of less than 10° Centigrade prior to use. | 03-21-2013 |
20130072576 | Cationic Nanogels For Biotechnological Applications - The present invention relates to a biocompatible cationic nanogel comprising a polymer network, said polymer network comprising polymer units interconnected with one another through a cross-linking agent, wherein said polymer network can be obtained by polymerizing N-vinylcaprolactam and a cross-linking agent in a dispersed medium, in the presence of a cationic initiator and a cationic or non-ionic emulsifier. The invention also relates to methods for obtaining the mentioned nanogels as well as to pharmaceutical compositions comprising them. | 03-21-2013 |
20130072577 | Vaporized Medicants and Methods of Use - A method and formulation for delivering an active compound in a vaporized state using low temperatures to vaporize the formulation. The formulation contains an inert non-reactive compound that lowers the heat of vaporization of the formulation, and the active compound. The formulation may optionally contain glycerin, alcohol, and/or water. Examples of inert non-reactive compounds that can sufficiently lower the heat of vaporization of the formulation include propylene glycol and polysorbate. The formulation can be vaporized using a hand-held low temperature vaporizer or atomizer | 03-21-2013 |
20130102687 | MICELLE COMPOSITIONS AND PROCESS FOR THE PREPARATION THEREOF - The present invention relates to a micelle composition comprising a hydrophobic compound and an amphiphilic block copolymer, wherein the amphiphilic block copolymer consists of a hydrophobic block A and a hydrophilic block B, the hydrophobic block A comprises at least one hydrophobic polymeric unit X and the hydrophilic block B comprises at least one hydrophilic polymeric unit Y whereby the X and Y blocks alternate. The present invention further relates to a process for the preparation of the micelle composition wherein the process comprises the steps of: a) dissolving the hydrophobic compound and the amphiphilic block copolymer in an organic solvent to form a solution, b) adding said organic solution into an aqueous medium, c) optionally repeating aforementioned steps. The micelle composition according to the present invention is useful in medical applications such as therapeutic cardiovascular applications, veterinary applications, food processing applications, flame retardant applications, coatings, adhesives and cosmetics, fabric/textiles, industrial and art applications. | 04-25-2013 |
20130158130 | POLYMER COMBINATIONS FOR COSMETIC PREPARATIONS - The invention comprises dermatological or cosmetic preparations comprising a triple combination of anionic polymer and two rheology modifying polymers which increase the viscosity of the preparation by at least 200% at a high shear rate and do not increase the viscosity at a low shear rate by more than 50%, thus imparting an improved sensory richness during spreading, in comparison to preparations without this combination. | 06-20-2013 |
20130172427 | FREE RADICAL POLYMERIZABLE COMPOSITIONS COMPRISING IONIC SILICONES - A composition including an actinic radiation or thermally curable polyorganosiloxane ionomer having one or more reactive groups, for example, vinyl, acrylate, epoxy groups. | 07-04-2013 |
20130217789 | BIODEGRADABLE LIQUOGEL AND PH SENSITIVE NANOCARRIERS - A delivery system using materials that form a liquogel or nanocarrier are described. The delivery system comprises hyperbranched polyglycerols (HPGs). The delivery system can include a drug or therapeutic agent and this system can be used to administer the drug or therapeutic agent locally. The delivery system provides for controlled release of the drug or therapeutic agent. | 08-22-2013 |
20130225696 | pH-SENSITIVE POLYMER HYDROGEL WITH DUAL IONIC TRANSITION AND USE THEREOF - Disclosed is a dual-transition polymeric hydrogel. Also, provided is the use of the dual-transition polymeric hydrogel as a carrier for drug delivery and disease diagnosis, or in the preparation of a polymeric hydrogel-type pharmaceutical composition comprising the physiologically active agent loadable into the block copolymer. Being sensitive to pH as well as temperature, the block copolymer can form a more stable hydrogel at suitable temperatures and pH values. In addition, the block copolymer exhibits a dual transition behavior with pH values so that it can carry ionic drugs, proteins, DNA, and markers, whether positively or negatively charged, simultaneously. Therefore, it can be applied to a sustained drug delivery system for sparingly soluble, hydrophobic drugs, and hydrophilic drugs. Further, it is safe to and stable within the body, and is expected to find various applications in the medical field. | 08-29-2013 |
20130225697 | TAMPER-RESISTANT DOSAGE FORM COMPRISING PHARMACOLOGICALLY ACTIVE COMPOUND AND ANIONIC POLYMER - The invention relates to a pharmaceutical dosage form having a breaking strength of at least 300 N and comprising a pharmacologically active compound, an anionic polymer bearing carboxylic groups, wherein the content of the anionic polymer is 20 wt.-%, based on the total weight of the pharmaceutical dosage form, and a nonionic surfactant. | 08-29-2013 |
20130245133 | AMINO ACID DERIVATIVES AND ABSORBABLE POLYMERS THEREFROM - The present invention relates to the discovery of new class of hydrolysable amino acid derivatives and absorbable polyester amides, polyamides, polyepoxides, polyureas and polyurethanes prepared therefrom. The resultant absorbable polymers are useful for drug delivery, tissue engineering, tissue adhesives, adhesion prevention, bone wax formulations, medical device coatings, stents, stent coatings, highly porous foams, reticulated foams, wound care, cardiovascular applications, orthopedic devices, surface modifying agents and other implantable medical devices. In addition, these absorbable polymers should have a controlled degradation profile. | 09-19-2013 |
20130289134 | COPOLYMERS CONTAINING POLYSILOXANE GROUPS AND HAVING AN EPOXY/AMINE SKELETAL STRUCTURE, AND USE THEREOF - The invention relates to a copolymer which contains at least one polysiloxane group and the skeletal structure of which is an addition compound of at least one amine and at least one epoxide. The invention further relates to the use of said products as additives in coating agents, plastics, or homogeneous dispersions, e.g. as a dispersing agent for organic and inorganic pigments and fillers in oil-based compositions, or as a surface modifying agent. | 10-31-2013 |
20130310464 | COPOLYMERS WHICH CAN BE OBTAINED FROM URETHANE-BASED, POLYSILOXANE-CONTAINING MACROMONOMERS, PROCESSES FOR THE PREPARATION THEREOF AND THEIR USE - The invention relates to a copolymer which can be obtained by free-radical copolymerization of one or more urethane-based, polysiloxane-containing macromonomers and one or more further free-radically polymerizable comonomers. Processes for preparing the copolymer and its use as additive in coating compositions and plastics and as wetting agent and dispersant in homogeneous dispersions are also described. | 11-21-2013 |
20130317118 | FUNCTIONALIZED AMINO ACIDS AND ABSORBABLE POLYMERS THEREFROM - The present invention relates to compounds of formula I and II, which are functionalized amino acids, and polymers formed from the same. | 11-28-2013 |
20130345319 | POLYMER HYDROGEL ADHESIVES FORMED WITH MULTIPLE CROSSLINKING MECHANISMS AT PHYSIOLOGIC PH - The present invention encompasses biocompatible reactants, biocompatible product hydrogels, methods of use thereof, and methods of synthesis thereof using a novel crosslinking mechanism between a first reactant compound including an N-Hydroxysuccinimide (NHS) ester group and a second reactant compound including a N-terminal cysteine amine group. In certain embodiments, one or more of the reactant compounds may be a macromonomer. | 12-26-2013 |
20140018440 | MEDICAL DEVICES HAVING POLYMER BRUSHES - According to an aspect of the present invention, internal medical devices are provided, which contain at least one surface region that comprises a polymer brush. The polymer brush, in turn, contains one or more types of hydrophobic polymer chains and one or more types of hydrophilic polymer chains. | 01-16-2014 |
20140024722 | Nanostructured Physically-Associating Hydrogels for Injectable, Responsive, and Tough Biomaterials - Described herein are block copolymer conjugates that form double-network hydrogels under appropriate conditions. The conjugates comprise a block of polymer end-group, a block of self-associating peptide or protein, and flexible linkers between the two. Hydrogels comprising the conjugates have the mechanical properties, including elastic modulus and fracture toughness, required for load-bearing applications, while maintaining desirable shear-thinning properties, for example, for injectability. | 01-23-2014 |
20140039067 | FILAMENTOUS POLYMER PARTICLES AND USE THEREOF AS RHEOLOGY MODIFIERS - The invention relates to polymer particles in the form of filaments formed by block copolymers, as well as to the use thereof as rheology modifiers for aqueous or organic solutions. A first aspect of the invention relates to filamentous polymer particles having a length/diameter ratio greater than 100, said particles being formed by block copolymers synthesized by controlled radical emulsion polymerization in emulsion, performed using at least one hydrophobic monomer in the presence of a water-soluble marcoinitiator. The invention is characterized in that the filamentous particles are obtained in an aqueous medium for the synthesis of said block copolymers, performed by heating the reaction medium to a temperature of 60 to 120° C., the final block copolymer containing between 10 and 50 mol. % of the water-soluble macroinitiator and the hydrophobic monomer conversion rate being at least 50%. A second aspect of the invention relates to a method for modifying the rheology of an organic or aqueous solution using said filamentous polymer particle. | 02-06-2014 |
20140039068 | Drug Delivery Compositions and Methods - The present invention provides compositions and methods for the delivery of therapeutics to a cell or subject. | 02-06-2014 |
20140057998 | USE OF HIGHLY-BRANCHED POLYCARBONATES IN COSMETIC AND DERMATOLOGICAL FORMULATIONS - The present invention relates to compositions which comprise highly-branched polycarbonates, to the use of these highly-branched polycarbonates in cosmetics and dermatology and to substituted highly-branched polycarbonates. | 02-27-2014 |
20140113975 | BIODEGRADABLE BLOCK COPOLYMERIC COMPOSITIONS FOR DRUG DELIVERY - An improved drug delivery composition and method of use is disclosed. The composition comprises one or more biodegradable block copolymer drug carriers; and a reconstitution enhancing and enabling agent comprising polyethylene glycol (PEG), a PEG derivative or a mixture of PEG and a PEG derivative. The composition can be administered as is or after being be dissolved or rapidly reconstituted in an aqueous vehicle to afford a homogeneous solution or uniform colloidal systems. | 04-24-2014 |
20140142198 | CROSS-LINKED POLY-E-LYSINE NON-PARTICULATE SUPPORT - The invention provides a non-particulate cross-linked poly-ε-lysine polymer. The poly-ε-lysine and cross linker are linked by amide bonds and may the cross linker has at least two functional groups capable of reacting with an alpha carbon amine of poly-ε-lysine. The polymer is suitably insoluble in water and other solvents and is provided in macro form for example a sheet, article or fibre. The macro form polymer is useful in a wide range of applications including wound treatment, as a medical diagnostic comprising a particulate support and a functional material bound or retained by the support and solid phase synthesis of peptides, oligonucleotides, oligosaccharides, immobilisation of species, cell culturing and in chromatographic separation. | 05-22-2014 |
20140155494 | TRI-MOLECULAR COMPLEXES AND THEIR USE IN DRUG DELIVERY SYSTEMS - This invention relates to macromolecular complexes useful in drug delivery systems, specifically tri-molecular complexes made between a water-soluble polymer and an acid-insoluble polymer in presence of a bridging molecule. In one aspect, the invention relates to a tri-molecular complex comprising gelatin, acrylic acid/methacrylic acid copolymers, and arginine for use in a soft capsule dosage form. In another aspect, the invention is directed to a tri-molecular complex a hydrophilic, film-forming, water-soluble polymer, a second water-soluble polymer, and a bridging molecule, wherein the second water-soluble polymer is less water-soluble than the hydrophilic, film-forming, water-soluble polymer. | 06-05-2014 |
20140171518 | STABLE AND COMPATIBLE POLYMER BLENDS - The present invention pertains to products and processes relating to compatible polymer blends comprising at least one sulfonated polymer and at least one non-sulfonated polymer. The sulfonated polymers may be produced using a number of sulfonating agents including a coordination complex of sulfur trioxide. The polymeric blended materials described herein are useful in a variety of applications, including as coatings for medical devices, protective clothing and fabric, laboratory equipment, vascular stents and shunts, absorbent materials and separation membranes, three-dimensional constructs, devices, and other uses. | 06-19-2014 |
20140194532 | Organopolysiloxane Elastomer Modified With Mono-/Diglycerin Derivative, And Use Therefor - The present invention relates to a glycerin derivative-modified organopolysiloxane elastomer comprising: | 07-10-2014 |
20140213661 | HYDROPHILIC INTERPENETRATING POLYMER NETWORKS DERIVED FROM HYDROPHOBIC POLYMERS - A composition having a hydrogel bearing side of a biostable polymer network, wherein the biostable polymer network comprises a first gradient of the biostable polymer, which biostable polymer network decreases in concentration from the hydrogel bearing side to a bone interface surface; and a second gradient of a biostable polyurethane network, which polyurethane network increases in concentration from the hydrogel bearing side to the bone interface surface, the bone interface surface useful for an orthopedic implant. | 07-31-2014 |
20140243425 | CONTROLLED RELEASE COMPOSITIONS FOR MODULATING FREE-RADICAL INDUCED DAMAGE AND METHODS OF USE THEREOF - Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with free-radical modulating agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s). | 08-28-2014 |
20140288189 | Water-Stable Hydrogel and Method Using Same - A hydrogel (I) comprising a polymer backbone comprising a plurality of repeat units, wherein one or more of the repeat units comprises a pendent water soluble polymer attached thereto by a linkage selected from the group consisting of amide, thioamide, urea, and thiourea. | 09-25-2014 |
20140309313 | IMMUNOCOMPATIBLE POLYMERS - A polymer matrix is provided comprising an amine-containing polyampholyte covalently crosslinked with an electrophilic polymer to yield an immunocompatible polymer matrix. A hydrogel system incorporating the polymer matrix is also provided. | 10-16-2014 |
20140316011 | ION SEQUESTERING ACTIVE PACKAGING MATERIALS - The invention described herein provides a modified material is a packaging material in which, at least one side, the product contact side, has been modified to sequester ions in order to prevent the ions from being available to promote degradative reactions in biological or chemical products such as food, beverages, pharmaceuticals, neutraceuticals, cosmetics, paints and chemicals. The invention described herein also includes methods of making the packaging materials and methods of using the packaging materials for preserving the integrity of biological and chemical compounds. | 10-23-2014 |
20140329913 | NANOPARTICLES WITH ENHANCED MUCOSAL PENETRATION OR DECREASED INFLAMMATION - Nanoparticles formed by emulsion of one or more core polymers, one or more surface altering materials, and one or more low molecular weight emulsifiers have been developed. The particles are made by dissolving the one or more core polymers in an organic solvent, adding the solution of the one or more core polymers to an aqueous solution or suspension of the emulsifier to form an emulsion, and then adding the emulsion to a second solution or suspension of the emulsifier to effect formation of the nanoparticles. In the preferred embodiment, the molecular weight of the emulsifiers is less than 1500, 1300, 1200, 1000, 800, 600, or 500 amu. Preferred emulsifiers include cholic acid sodium salt, dioctyl sulfosuccinate sodium, hexadecyltrimethyl ammonium bromide, saponin, TWEEN® 20, TWEEN® 80, and sugar esters. The surface altering materials are present in an amount effective to make the surface charge of the particles neutral or essentially neutral when the one or more emulsifiers are charged. The emulsifiers have an emulsification capacity of at least about 50%, preferably at least 55, 60, 65, 70, 75, 80, 85, 90, or 95%. | 11-06-2014 |
20140336276 | IN SITU CROSSLINKING HYDROGEL COMPRISING gamma-POLYGLUTAMIC ACID AND METHOD FOR PRODUCING THE SAME - Disclosed are a biodegradable, biocompatible hydrogel that can be used for sealants of suppressing the leakage of blood or air during surgical operation, tissue adhesives, anti-adhesive agents and drug delivery carriers, and a method for producing the same | 11-13-2014 |
20140350123 | NONAQUEOUS METHOD OF DISPERSING A WATER SOLUBLE POLYMER - Described are methods of dispersing and hydrating a water soluble polymer, comprising forming a nonaqueous slurry of polypropylene glycol, water soluble polymer, and hydrophobically modified ethoxylated urethane, provided that the slurry contains less than five percent water; and then contacting the nonaqueous slurry with water to disperse and hydrate the water soluble polymer. | 11-27-2014 |
20140350124 | CHAIN-EXTENDED POLYSILOXANE CROSSLINKERS WITH DANGLING HYDROPHILIC POLYMER CHAINS - The invention provide a class of linear chain-extended polysiloxane crosslinkers which comprises two terminal ethylenically unsaturated groups, at least two polysiloxane segments, and dangling hydrophilic polymer chains each covalently attached to a divalent organic radical separating each pair of adjacent polysiloxane segments. The present invention is also related to a polymer comprising crosslinking units derived from chain-extended polysiloxane crosslinker of the invention and to ophthalmic lenses comprising such a polymer. | 11-27-2014 |
20140364510 | CONTROLLED RELEASE AURAL PRESSURE MODULATOR COMPOSITIONS AND METHODS FOR THE TREATMENT OF OTIC DISORDERS - Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with aural pressure modulating agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s). | 12-11-2014 |
20150045451 | POLYMERIC BIOMATERIALS DERIVED FROM MONOMERS COMPRISING HYDROXYACIDS AND PHENOL COMPOUNDS AND THEIR MEDICAL USES - The present invention provides new classes of phenolic compounds derived from hydroxyacids and tyrosol or tyrosol analogues, useful as monomers for preparation of biocompatible polymers, and the biocompatible polymers prepared from these monomeric hydroxyacid-phenolic compounds, including novel biodegradable and/or bioresorbable polymers. These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processibility are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic formulations. The invention also provides methods for preparing these monomeric hydroxyacid-phenolic compounds and biocompatible polymers. | 02-12-2015 |
20150057367 | MICRO-PARTICLES CONTAINING A 3-D POLYMERIC STRUCTURE - Micro-sized particles having a polymeric structure of cells are provided. Also provided is a method of producing micro-sized particles having a polymeric structure comprising: (1) forming a homogenous solution by heating a mixture of a high molecular weight polymer and a low molecular weight material, wherein said low molecular weight material makes up at least about 50% by weight of the homogenous solution, (2) forming a dispersed solution by dispersing the homogenous solution formed in step (1) into an inert material, (3) cooling the dispersed solution to cause the high molecular weight polymer to phase separate from the low molecular weight material, (4) forming solid particles comprised of said low molecular weight material trapped inside a structure of cells of said high molecular weight polymer, and (5) removing the solid particles from the dispersed solution. | 02-26-2015 |
20150065586 | AMINO ACID DERIVATIVES AND ABSORBABLE POLYMERS THEREFROM - The present invention relates to the discovery of new class of hydrolysable amino acid derivatives and absorbable polyester amides, polyamides, polyepoxides, polyureas and polyurethanes prepared therefrom. The resultant absorbable polymers are useful for drug delivery, tissue engineering, tissue adhesives, adhesion prevention, bone wax formulations, medical device coatings, stents, stent coatings, highly porous foams, reticulated foams, wound care, cardiovascular applications, orthopedic devices, surface modifying agents and other implantable medical devices. In addition, these absorbable polymers should have a controlled degradation profile. | 03-05-2015 |
20150073059 | ORGANOPOLYSILOXANE GELS - Organopolysiloxane gels produced by crosslinking an unsaturated organopolysiloxane resin with a crosslinking agent in the presence of a diluent have excellent sensory properties such as properties desirable in a variety of cosmetics products. | 03-12-2015 |
20150099808 | AMPHIPHILIC COPOLYMERS AND COMPOSITIONS CONTAINING SUCH POLYMERS - Amphiphilic copolymer, containing at least a hydrophilic chain segment (A) and a hydrophobic chain segment (B), wherein the hydrophilic chain segment (A) contains peptides and wherein the hydrophobic chain segment (B) contains acetal groups or orthoester groups. The hydrophilic chain segment (A) preferably contains glutamine/glutamic acid units or asparagines/aspartic acid units, making a biodegradable copolymer which can form a thermogel. | 04-09-2015 |
20150105476 | O/W TYPE COSMETIC COMPOSITION WITH IMPROVED DOSAGE FORM STABILITY - The present invention relates to an O/W type cosmetic composition with improved formulation stability, and more particularly, to an O/W type cosmetic composition comprising a branched polymer having a lipophilic alkyl side chain and an anionic surfactant, as active ingredients for improving formulation stability. | 04-16-2015 |
20150315434 | New Photoactive Bioadhesive Compositions - A novel diazirine-based biocompatible polymer that can be used as on-demand or tunable bioadhesive and applied across various clinically important surfaces. The biocompatible polymer comprises a single strand of repeating units and up to 5,000 photoreactive diazirine groups covalently attached to it. A bioadhesive composition comprises the polymer of the present invention and suitable solvents, surfactants, stabilizers, fillers and other additives. The composition may additionally contain metallic particles of size less than 50 micron made of rare earth elements and has UV or NIR transparency less than 1 optical density unit per 1 centimetre. The poly-diazirine surface grafted thin films can be used for minimally invasive surgeries. | 11-05-2015 |
20150337128 | RELEASE MEDIA - The present invention relates to a composition comprising polymer particles and functionalised stimulus responsive polymer; the polymer particles (i) comprising block co-polymer, and (ii) having a core-shell structure, said block co-polymer comprising (a) a non-stimulus responsive polymer block that forms at least part of the core structure, and (b) a stimulus responsive polymer block that forms at least part of the shell structure; wherein the stimulus responsive polymer of both the polymer particles and the functionalised stimulus responsive polymer are responsive to at least one common stimulus. | 11-26-2015 |
20150366972 | METHODS AND MATERIALS FOR THERAPEUTIC DELIVERY - Methods for preparing a supramolecular therapeutic agent delivery assembly are provided. A hydrophilic precursor, a hydrophibic precursor, and an aromatic diamine precursor may be combined to form an amphiphilic block co-polymer. The block co-polymer may undergo a cross-linking polymerization process and a therapeutic agent may be incorporated into the resulting supramolecular assembly. The supramolecular assembly may comprise HT, PHT, HA, and/or PHA materials. | 12-24-2015 |
20150368406 | BIODEGRADABLE AND BIOCOMPATIBLE SHAPE MEMORY POLYMERS - This invention relates to shape memory block copolymers comprising: at least one switching segment having a T | 12-24-2015 |
20150376405 | BIOENVIRONMENT-SENSITIVE NANOPARTICLE COMPRISING POLYMER HAVING COMPLEMENTARY CHARGES - A bioenvironment-sensitive nanoparticle including a polymer having complementary charges, a method of manufacturing the same, and a pharmaceutical use of the bioenvironment-sensitive nanoparticle are disclosed. The bioenvironment-sensitive nanoparticle can be useful in stably and effectively delivering a target material such as a drug even when used at a small quantity since the nanoparticle is stable in extracellular environments. Also, the bioenvironment-sensitive nanoparticle can be useful in selectively diagnosing or treating cancer cells since the nanoparticle is specific to environments of the cancer cells. | 12-31-2015 |
20160000922 | FUNCTIONALISED TRIBLOCK COPOLYMERS AND COMPOSITIONS CONTAINING SUCH POLYMERS - Amphiphilic triblock copolymers B-A-B, wherein A is a linear poly(ethylene glycol) block, having a number average molecular weight (M | 01-07-2016 |
20160030581 | BIODEGRADABLE DRUG DELIVERY COMPOSITIONS - A biodegradable drug delivery compositions comprising a triblock copolymer containing a polyester and a polyethylene glycol and a diblock copolymer containing a polyester and an end-capped polyethylene glycol, as well as a pharmaceutically active principle is disclosed. | 02-04-2016 |
20160106676 | METHOD FOR THE PREPARATION OF DEGRADABLE MICROGEL PARTICLES, AND MICROGEL COMPOSITIONS THEREOF - The present application relates to an aqueous method for the preparation of microgel particles using a stimuli-responsive prepolymer | 04-21-2016 |
20160177038 | SILICONE MODIFIED BY LONG-CHAIN HYDROCARBON GROUP-CONTAINING DIGLYCERIN DERIVATIVE, AND USE THEREOF | 06-23-2016 |