| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 514452000 | Plural ring oxygens in the hetero ring | 41 |
| 20130085175 | PROCESS FOR THE PREPARATION OF SULFAMIDE DERIVATIVES - The present invention is directed to an improved process for the preparation of sulfamide derivatives. | 04-04-2013 |
| 20130085176 | PROCESS FOR THE PREPARATION OF SULFAMIDE DERIVATIVES - The present invention is directed to a process for the preparation of sulfamide derivatives. | 04-04-2013 |
| 20100105763 | PHARMACEUTICAL COMPOSITION, HEALTH FOOD COMPOSITION AND INOS INHIBITORS, CONTAINING THEOPEDERIN DERIVATIVES - The present invention relates to a pharmaceutical composition and a health food composition for the prevention and treatment of immune- and autoimmune diseases such as septic shock, hemorrhagic shock, rheumatoid arthritis, osteoarthritis, inflammatory bowel disease and multiple sclerosis, and metabolic diseases such as arteriosclerosis and type II diabetes, and an inducible nitric oxide synthase (iNOS) inhibitor composition containing theopederin derivatives as an active ingredient. The composition of the present invention can be effective in the prevention and treatment of immune diseases and metabolic diseases by inhibiting the excessive generation of NO by inhibiting the activity of iNOS. | 04-29-2010 |
| 20090042973 | Inhibitors of aspartyl protease - The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting HIV-1 and HIV-2 protease activity and consequently, may be advantageously used as anti-viral agents against the HIV-1 and HIV-2 viruses. This invention also relates to methods for inhibiting the activity of HIV aspartyl protease using the compounds of this invention and methods for screening compounds for anti-HIV activity. | 02-12-2009 |
| 20080293806 | Odor Reduction Compositions - An odor-reducing composition for counteracting malodour in which the composition includes an odor reducing material of the type phenyl ethyl methyl ether, Cyprisate, Camonal and paracresyl methyl ether and a method for counteracting malodour employing such a composition. | 11-27-2008 |
| 20080207743 | Biologically Active Taxane Analogs and Methods of Treatment - The present application relates to new taxane analogs, pharmaceutical compositions comprising such analogs and methods of treating cancer comprising such compositions. The compounds according to the present application have the general formula: | 08-28-2008 |
| 20110294875 | 4-((PHENOXYALKYL)THIO)-PHENOXYACETIC ACIDS AND ANALOGS - The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR delta modulators to treat or inhibit the progression of, for example, dyslipidemia. | 12-01-2011 |
| 20080207744 | Biologically active taxane analogs and methods of treatment - The present application relates to new taxane analogs, pharmaceutical compositions comprising such analogs and methods of treating cancer comprising such compositions. The compounds according to the present application have the general formula: | 08-28-2008 |
| 20110207805 | COMPOSITION OF FLAVANOLIGNAN AND AMINO ACID WITH IMPROVED WATER SOLUBILITY - The invention relates to a composition containing flavanolignans, e.g., isolated from | 08-25-2011 |
| 20090163576 | COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS - Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, polycystic ovary syndrome, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis are disclosed, compound of the formula (I): wherein n is 1 or 2; m is 0, 1, 2, 3, 4, 5, 6, 7 or 8; q is 0 or 1; t is 0 or 1; R | 06-25-2009 |
| 20090209634 | USE OF BENZO-FUSED HETEROCYCLE SULFAMIDE DERIVATIVES FOR DISEASE MODIFICATION / EPILEPTOGENESIS - The present invention is a method for treating, preventing, reversing, arresting or inhibiting the occurrence, development and maturation of seizures or seizure-related disorders. More specifically, the present invention is directed to methods for the use of benzo-fused heterocycle sulfamide derivatives of formula (I) and formula (II) as described herein to therapeutically or prophylactically treat, prevent, reverse, arrest or inhibit epileptogenesis and epilepsy. | 08-20-2009 |
| 20100179216 | AMINE COMPOUND AND PHARMACEUTICAL USE THEREOF - Provided is a novel amine compound represented by the following formula (I) having a superior peripheral blood lymphocyte decreasing action and superior in the immunosuppressive action, rejection suppressive action and the like, which shows decreased side effects of, for example, bradycardia and the like, or a pharmaceutically acceptable acid addition salt thereof, or a hydrate thereof, or a solvate thereof. | 07-15-2010 |
| 20090247618 | PROCESS FOR PREPARATION OF BENZO-FUSED HETEROARYL DERIVATIVES - The present invention is directed to processes for the preparation of benzo-fused heteroaryl derivatives, useful for the treatment of epilepsy and related disorders. The present invention is further directed to processes for the preparation of intermediates in the synthesis of the benzo-fused heteroaryl derivatives. | 10-01-2009 |
| 20090247617 | PROCESS FOR THE PREPARATION OF BENZO-FUSED HETEROARYL SULFAMATES - The present invention is directed to a process for the preparation of benzo-fused heteroaryl sulfamates, useful for the treatment of epilepsy and related disorders. | 10-01-2009 |
| 20100184847 | COMPOSITIONS FOR SKIN PROTECTION AND IMPROVEMENT OF SKIN DISEASES CONTAINING THE DIBENZO-P-DIOXINE DERIVATIVES - The present invention relates to compositions for skin protection and improvement that contain dibenzo-p-dioxine derivatives as effective components. Since the compositions for skin protection and improvement that contain the dibenzo-p-dioxine derivative according to the present invention have excellent functions such as moisturizing and/or wrinkle prevention which are useful in prevention and improvement of various skin diseases, they can be extensively used as cosmetic ingredients or pharmaceutical agents for prevention and improvement of skin diseases. | 07-22-2010 |
| 20090298928 | COMPOSITION AND METHOD FOR SCALP AND HAIR TREATMENT - Provided is a composition for scalp and hair treatment, comprising a menthol derivative and a prostaglandin compound having two hetero atoms at the 15 position. The composition of the present invention is effective not only for preventing dandruff and itchy scalp but also for preventing or treating hair loss, baldness, or hair thinness. | 12-03-2009 |
| 20120196926 | BENZOPYRAN COMPOUNDS AS MELANOGENESIS MODIFIERS AND USES THEREOF - Provided are benzopyran compounds of formula I, for example, pomiferin-3′,4′-dimethyl ether, and the use of such compounds and compositions thereof to modulate (e.g., inhibit) melanogenesis and pigmentation. | 08-02-2012 |
| 20110028539 | Biologically active taxane analogs and methods of treatment - The present application relates to new taxane analogs, pharmaceutical compositions comprising such analogs and methods of treating cancer comprising such compositions. The compounds according to the present application have the general formula: | 02-03-2011 |
| 20090286868 | DERIVATIVES OF DIOXAN-2-ALKYL CARBAMATES, PREPARATION THEREOF AND APPLICATION THEREOF IN THERAPEUTICS - A compound corresponding to general formula (I): | 11-19-2009 |
| 20120142766 | SUBSTITUTED 1,3-DIOXANES AND THEIR USES - The present invention relates to compounds containing 1,3-dioxane moiety, pharmaceutical compositions thereof, and the use of the compounds and compositions for the modulation of thromboxane A2 or a peroxisome proliferator-activated receptor. The compounds, analogs, and pharmaceutically acceptable salts thereof, and pharmaceutical compositions can be used in the treatment and prevention of cancer. | 06-07-2012 |
| 20110009480 | Biologically active taxane analogs and methods of treatment - The present application relates to new taxane analogs, pharmaceutical compositions comprising such analogs and methods of treating cancer comprising such compositions. The compounds according to the present application have the general formula: | 01-13-2011 |
| 20110124718 | Reduction Of Acetaminophen Toxicity By Dietary Milk Thistle Extract - The present invention is directed to the reduction of acetaminophen toxicity by dietary milk thistle extract. Milk thistle has been reported to have protective effects on the liver and to greatly improve its function. It is typically used to treat liver cirrhosis, chronic hepatitis (liver inflammation), and toxin-induced liver damage. The present invention, for the first time, combines milk thistle and acetaminophen in a unique and novel way to provide single dosages containing both ingredients, whether dispensed in a liquid suspension, chewable tablets, coated caplets, gelcaps, geltabs, and suppositories. | 05-26-2011 |
| 20110077292 | FORSKOLIN CARBONATES AND USES THEREOF - The present invention provides methods for reducing body weight. In particular, the present invention provides methods for reducing body weight by administering a composition comprising a forskolin 1α,9α-carbonate compound of the formula: | 03-31-2011 |
| 20100087517 | PRODRUGS OF SUBSTITUTED 1,3-DIOXANES AND THEIR USES - The present invention relates to prodrugs of compounds containing 1,3-dioxane moiety, pharmaceutical compositions thereof, and the use of the compounds and compositions for the modulation of thromboxane A2 or a peroxisome proliferator-activated receptor. The prodrugs of the compounds, analogs, and pharmaceutically acceptable salts thereof, and pharmaceutical compositions can be used in the treatment and prevention of cancer. | 04-08-2010 |
| 20100063138 | NOVEL SUBSTITUTED SULFAMIDE DERIVATIVES - The present invention is directed to novel substituted sulfamide derivatives, pharmaceutical compositions containing said derivatives and the use of said derivatives form in the treatment of anxiety and related disorders; bipolar depression and mania; depression; epilepsy and related disorders; epileptogenesis; glucose related disorders; lipid related disorders; migraine; obesity; pain; substance abuse and as neuroprotective agents. The present invention is further directed to a process for the preparation of the novel substituted sulfamide derivatives. | 03-11-2010 |
| 20090137660 | Cytokine Modulators Using Cyclic Glycerides of Essential Polyunsaturated Fatty Acids - A method of treating a patient in need of therapy for a cytokine dysregulation comprising administering to that patient a therapeutically effective dose of a compound of general formula: (I) wherein R | 05-28-2009 |
| 20110021614 | USE OF SILYMARIN AND SILYBIN IN THE TREATMENT OF NEURAL INJURY - The present invention provides a method of treating neural injury, e.g., spinal cord injury (SCI), or enhancing recovery from the neural injury with silymarin or silybin. | 01-27-2011 |
| 20100324130 | DAA PERIPHERAL BENZODIAZEPINE RECEPTOR LIGAND FOR CANCER IMAGING AND TREATMENT - Peripheral Benzodiazepine Receptor (PBR) is an attractive target for tumor imaging and treatment due to its up-regulation in numerous cancer cell types. DAA1 106 is a selective PBR ligand with high binding affinity. Aspects of the present invention are series of functionalized DAA1 106 analogs, which can be conjugated to a variety of signaling and treatment moieties, and are widely applicable in PBR targeted molecular imaging and drug delivery. | 12-23-2010 |
| 20100029756 | NOVEL COMPOSITIONS CONTAINING ISOLATED TETRAMERIC TYPE A PROANTHOCYANADIN AND METHODS OF USE AND MANUFACTURE - The present invention relates to compositions containing an isolated novel tetrameric type A proanthocyanidin isomer having a formula of C | 02-04-2010 |
| 20100004324 | ANTIMICROBIAL COMPOUNDS AND METHODS OF USE THEREOF - In one aspect, the invention relates to compounds and methods useful for activating heme sensor systems; for decreasing virulence of bacteria, for example, | 01-07-2010 |
| 20120041058 | COMPOSITION OF TRADITIONAL CHINESE MEDICINE FOR REDUCING BLOOD FAT AND PREPARATION METHOD THEREOF - Composition of traditional Chinese medicine for reducing blood lipid with components of the crude drug of artemisinins and the crude drug of ursolic acid, wherein the ratio of the crude drug of artesunate and the crude drug of ursolic acid is 1:25-25:1 by weight. The preparation method of such composition includes the following steps: the crude drug of artesunate and the crude drug of ursolic acid are mixed at the weight ratio mentioned above, comminuted, then screened through 120 mesh sieve to obtain the composition; or the crude drug of artesunate and the crude drug of ursolic acid are weighed at the weight ratio mentioned above, comminuted, screened through 120 mesh sieve separately, then mixed and screened for three times to obtain the composition. The composition of the present invention can be formulated into formulations for injection, oral administration with pharmaceutically acceptable carriers, and can be used for preparing medicaments for reducing blood lipid. | 02-16-2012 |
| 20120029064 | FORMULATION OF SILIBININ WITH HIGH EFFICACY AND PROLONGED ACTION AND THE PREPARATION METHOD THEREOF - A high-efficacy, long-acting formulation of silibinin, comprising silibinin solid dispersion, silibinin-loaded silica nanoparticles, slow-release matrix material and release enhancer, wherein the mass ratio of these components is silibinin solid dispersion:silibinin-loaded silica nanoparticles:slow-release matrix material:release enhancer=1:0.5˜1.25:0.1˜0.3:0.1˜0.3; the drug loading rate of the said silibinin-loaded silica nanoparticles is 51.29˜51.77%; the said silibinin solid dispersion contains povidone K30, soybean lecithin, acrylic resin IV, wherein the mass ratio between silibinin and other medical accessories is silibinin:povidone K30:soybean lecithin:acrylic resin IV=1:1˜3:0.3˜0.8:0.2˜0.5. Compared with the existing formulations, the half life of the high-efficacy, long-acting formulation of silibinin disclosed in this invention is 14.8 times longer while the mean residence time (MRT) of which is 4.52 times longer; when tested in vivo in Beagle dogs, this new formulation of silibinin presents a smoother concentration-time curve and reaches the continuous release for 72 hours. This invention discloses its preparation method. | 02-02-2012 |
| 20120157520 | DIOXANES DERIVED FROM REGROUPING CARBOHYDRATES AND C-GLYCOSIDES, PROCESS FOR OBTAINING SAME AND USES THEREOF - The present invention relates to compounds with a dioxane nucleus derived from carbohydrates and C-glucosides, process for obtaining same, to the use of such compounds as cytotoxic and antiproliferative agents and to the use thereof for producing a cancer treatment drug. | 06-21-2012 |
| 20120316230 | Compounds and their Salts Specific to the PPAR Receptors and the EGF Receptors and their Use in the Medical Field - The present invention relates to compounds of formula (I), where R | 12-13-2012 |
| 20090131511 | PALMARUMYCIN BASED INHIBITORS OF THIOREDOXIN AND METHODS OF USING SAME - Embodiments of the present invention relate to inhibitors of thioredoxin. Certain embodiments relate to palmarumycin based compounds and methods of using the same. Such compounds may be useful in inhibiting the overexpression of thioredoxin, inhibiting tumor growth and treating cancer. | 05-21-2009 |
| 20120178800 | SYNERGISTIC ANTIMICROBIAL COMPOSITION - A synergistic antimicrobial composition having two components. The first component is glutaraldehyde. The second component is 2,6-dimethyl-1,3-dioxan-4-yl acetate. | 07-12-2012 |
| 20120178799 | ENERGY BEVERAGE WITH CREATINE AND CAFFEINE COMBINATION - The present invention is an energy drink that included both creatine and caffeine, which provides superior energy, concentration and performance over other energy beverages/liquids. The invention can include other vitamins and beneficial additives, but is intended to be unflavored and unsweetened. | 07-12-2012 |
| 20120122965 | COMPOSITIONS FOR SKIN PROTECTION AND IMPROVEMENT OF SKIN DISEASES CONTAINING THE DIBENZO-P-DIOXINE DERIVATIVES - The present invention relates to compositions for skin protection and improvement that contain dibenzo-p-dioxine derivatives as effective components. | 05-17-2012 |
| 20100204313 | Modulation of nerve pain activity by resiniferatoxin and uses thereof - The present invention is directed to the treatment of chronic pain that occurs in chronic disease such as chronic pancreatitis by the application, of the drug, resiniferatoxin, to a visceral organ, such as the stomach, which then reduces the pain present in a second visceral organ, such as the pancreas. The reduction of said pain associated with the chronic disease occurs through the drug-induced desensitization of primary pain-sensing neurons that are shared between the two visceral organs. Additionally, application of the drug resiniferatoxin into the first organ, reduces the inflammation that occurs in the second diseased organ. This modulation of shared nerve activity by application of resiniferatoxin, may also be directed to modulate the pain and inflammation in any two visceral organs that share a common spinal or vagal nerve. Finally, application of the drug resiniferatoxin to either the stomach or the jejunum may be used to treat disease and disorders that involve gastroparesis. The resiniferatoxin improves gastric emptying and reduces nausea, thus may be effective therapy for these conditions. | 08-12-2010 |
| 20120088823 | COMPOSITION AND METHOD FOR SCALP AND HAIR TREATMENT - Provided is a composition for scalp and hair treatment, comprising a menthol derivative and a prostaglandin compound having two hetero atoms at the 15 position. The composition of the present invention is effective not only for preventing dandruff and itchy scalp but also for preventing or treating hair loss, baldness, or hair thinness. | 04-12-2012 |
| 20090318544 | CRYSTALLINE FORM OF (2S)-(-)-N-(6-CHLORO-2,3-DIHYDRO-BENZO[1,4]DIOXIN-2-YLMETHYL)-SULFAMIDE - The present invention is directed to a novel crystalline form of (2S)-(−)-N-(6-chloro-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-sulfamide, pharmaceutical compositions containing said crystalline form and the use of said crystalline form in the treatment of anxiety and related disorders; bipolar depression and mania; depression; epilepsy and related disorders; epileptogenesis; glucose related disorders; lipid related disorders; migraine; obesity; pain; substance abuse; or for neuroprotection. The present invention is further directed to a process for the preparation of the novel crystalline form. | 12-24-2009 |
