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The additional hetero ring consists of two nitrogens and three carbons

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514 - Drug, bio-affecting and body treating compositions

514001000 - DESIGNATED ORGANIC ACTIVE INGREDIENT CONTAINING (DOAI)

514183000 - Heterocyclic carbon compounds containing a hetero ring having chalcogen (i.e., O,S,Se or Te) or nitrogen as the only ring hetero atoms DOAI

514277000 - Hetero ring is six-membered consisting of one nitrogen and five carbon atoms

514336000 - Additional hetero ring containing

514340000 - Ring nitrogen in the additional hetero ring (e.g., oxazole, etc.)

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Entries
DocumentTitleDate
20100063105PHARMACEUTICAL USES AND SYNTHESIS OF NICOTINANILIDE-N-OXIDES - Disclosed are nicotinanilide-N-oxide compounds, methods for their production, pharmaceutical compositions which include these compounds, and methods for their use in various therapies.03-11-2010
20100048638HEPARAN SULFATE INHIBITORS - Provided herein are heparan sulfate inhibitors, including modulators of heparan sulfate glycosylation, heparan sulfate sulfation, and/or heparan sulfate epimerization.02-25-2010
20120184583MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS - The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.07-19-2012
20100137374SOLID FORMULATIONS OF CARBOXAMIDE ARTHROPODICIDES - Disclosed is a solid arthropodicide composition comprising by weight 06-03-2010
20130085164Imidazole Derivatives - The present application provides novel imidazole compounds and pharmaceutically acceptable salts thereof. Also provided are methods for preparing these compounds. These compounds are useful in inhibiting CYP17 activity by administering a therapeutically effective amount of one or more of the compounds to a patient. By doing so, these compounds are effective in treating conditions associated with CPY17 activity. A variety of conditions can be treated using these compounds and include diseases which are characterized by abnormal cellular proliferation. In one embodiment, the disease is cancer, such as prostate cancer.04-04-2013
20100048640HYDRAZIDE COMPOUND AND HARMFUL ARTHROPOD-CONTROLLING AGENT CONTAINING THE SAME - Disclosed is a hydrazine compound represented by the formula (1) below, which has an excellent control activity against a harmful arthropod. (1) (In the formula, R02-25-2010
20100076030METHODS OF TREATING RHEUMATOID ARTHRITIS - Imidazole-based compounds, compositions comprising them, and methods of their use for the treatment, prevention and management of inflammatory and autoimmune diseases and disorders are disclosed. Particular compounds are of formula I:03-25-2010
20120245204Unknown - Heteroarylpiperidine and -piperazine derivatives of the formula (I)09-27-2012
20130079375MULTIHETEROARYL COMPOUNDS AS INHIBITORS OF H-PGDS AND THEIR USE FOR TREATING PROSTAGLANDIN D2 MEDIATED DISEASES - Multiheteroaryl compounds, their preparation, pharmaceutical compositions comprising these compounds, and their pharmaceutical use in the prevention and treatment of prostaglandin D03-28-2013
20130040995NOVEL COMPOUNDS - There is provided inter alia a compound of formula (I):02-14-2013
20090176843SUBSTITUTED-ARYL-2-PHENYLETHYL-1H-IMIDAZOLE COMPOUNDS AS SUBTYPE SELECTIVE MODULATORS OF ALPHA 2B AND/OR ALPHA 2C ADRENERGIC RECEPTORS - A compound having selective modulating activity at the alpha 2B and/or alpha 2C adrenergic receptor subtypes is represented by the general Formula 1:07-09-2009
20100041709SUBSTITUTED N-(4-CYANO-1H-PYRAZOL-3-YL)METHYLAMINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF - The present invention relates to compounds corresponding to formula (I):02-18-2010
200901314832-PYRIDINE DERIVATIVES AS INHIBITORS OF NEUTROPHILE ELASTASE - The invention provides compounds of formula (I) wherein R05-21-2009
20100130560FUNGICIDE 2-PYRIDYL-METHYLENE-THIO CARBOXAMIDE OR 2-PYRIDYL-METHYLENE-N-SUBSTITUTED CARBOXIMIDAMIDE DERIVATIVES - The present invention relates 2-pyridyl-methylene-thiocarboxamide or 2-pyridyl-methylene-N-substituted-carboximidamide derivatives of formula (I) wherein A represents a carbo-linked 5-membered heterocyclyl group; T represents S, N—R05-27-2010
20090306147BIOLOGICAL EFFICACY OF AGROCHEMICAL COMPOSITIONS ON APPLICATION IN THE GROWTH SUBSTRATE SUITABLE FORMULATIONS AND USE THEREOF - In soil applications, the action of crop protection compositions comprising active compounds from the classes of the neonicotinoids, the pyrethroids, the butenolides, the ketoenols, the phenylpyrazoles or the fungicides can be improved by adjuvants. The present invention describes corresponding methods and suitable compositions.12-10-2009
20130072525NITRATE AND DIAZENIUMDIOLATE DERIVATIVES OF PIOGLITAZONE - Nitrate ester and diazeniumdiolate derivatives of pioglitazone are described. They have valuable properties in the treatment of vascular and metabolic diseases, for example type 2 diabetes.03-21-2013
20110015237SOLID COMPOSITION FOR PEST CONTROL - To provide an anthranilamide formulation compound for improving pest controlling effects.01-20-2011
20090298888Method of improving plant development and increasing the resistance of plants to soil-borne harmful fungi - The present invention relates to a method of improving plant growth and increasing the resistance of plants to soil-borne harmful fungi by directly admixing neonicotinoid-containing formulations into nutrient solutions conventionally employed in raising plants.12-03-2009
20090270461Fungicide n-cycloalkyl-carboxamide, thiocarboxamide and n-substituted-carboximidamide derivatives - The present invention relates to N-cycloalkyl-carboxamide, N-cycloalkyl-thiocarboxamide and N-cycloalkyl-N-substituted carboximidamide derivatives of formula (I) wherein A represents carbo-linked, 5-membered heterocyclyl groups, T represents O, S, NR10-29-2009
200902704622-SULFANYL-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR USE AS CYTOKINE INHIBITORS - The invention relates to 2-thio-substituted imidazole derivatives of the Formula I, and to methods of use thereof.10-29-2009
20090270460FXR AGONISTS - Compounds of formula wherein variables are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and related diseases.10-29-2009
20130065928BIOMARKERS FOR PI3K-DRIVEN CANCER - Disclosed is the discovery that the mTORC2 complex plays a role in the regulation of PKN3 phosphorylation at the turn motif threonine; and the use of the phosphorylation status of the turn motif threonine of PKN3 as a biomarker. In some embodiments, the phosphorylation status of the turn motif threonine of PKN3 is determined using an antibody that specifically binds to the turn motif threonine of a PKN3 protein, such as an anti-phosphoT860 antibody. In some embodiments, the invention relates to methods for screening compounds that have cancer therapeutic potential, methods for diagnosing cancer, methods for determining the prognosis of a patient suffering from cancer, methods for stratifying patients in a clinical trial, methods for treating a patient suffering from cancer, and methods for determining the effectiveness of a particular treatment regimen.03-14-2013
20120115911SEED INDEX SYSTEM FOR TREATING AGRICULTURAL SEEDS - Seed index system and methods for treating agricultural seeds with one or more seed care products employing a size-adjusted application rate based on the size of the seeds. Such size-adjusted application rates can be determined by a supplier of seed care products and communicated to an applicator who applies the seed care product to a quantity of seeds. Such size-adjusted application rates can be in the form of a chart, an equation, or a calculator.05-10-2012
20110136874FUNGICIDAL N-(2-PYRIDYLPROPYL) CARBOXAMIDE DERIVATIVES AND THEIR OXA, AZA AND THIA ANALOGUES - The present invention relates to fungicide N-(2-pyridylpropyl)carboxamide derivative and its oxa, aza and thia analogues of formula (I), their process of preparation and intermediate compound for their preparation, their use as fungicides, particularly in the form of fungicidal compositions and methods for the control of phytopathogenic fungi of plants using these compounds or their compositions.06-09-2011
20100120867METHOD OF TREATMENT - Improvements in the treatment of patients suffering from frequent heartburn are provided by a treatment regimen comprising administration of an effective daily amount of lansoprazole or a pharmaceutically acceptable salt thereof for up to 14 days.05-13-2010
20100179196COMPOSITIONS AND METHODS FOR DEPLOYING A TRANSGENIC REFUGE AS A SEED BLEND - Methods and compositions for deploying refuge seeds together with transgenic crop seeds are provided. The refuge seeds can be non-transgenic seeds of a similar variety to that of the transgenic crop seeds, or the refuge seeds can be a transgenic variety.07-15-2010
20090036497ECTOPARASITE CONTROL METHOD - This invention relates to a method of controlling or preventing infestations of ectoparasites, preferably hematophageous ectoparasites, on an animal by administering to the animal a composition comprising an parasiticidally effective amount of a compound of Formula 1, or an N-oxide, or a pharmaceutically or veterinarily acceptable salt thereof,02-05-2009
20090069386Liquid Composition, Process for Producing the Liquid Composition,and Ectoparasite Controlling Agent for Use in Mammals and Avians - A liquid composition comprising (a) 21 to 70 parts by weight of a solvent having no nitrogen atom and having a carbonyl or sulfonyl group in the molecule, (b) 30 to 78.9 parts by weight of at least one component selected from the group consisting of a non-cyclic alcohol, an alkylene glycol, a polyalkylene glycol, a triol, a glycol monoacetate and a glycol monoalkyl ether, (c) 0.001 to 30 parts by weight of a physiologically active ingredient, and (d) 0.001 to 49 parts by weight of water.03-12-2009
20100197738FLY CONTROL METHOD - This invention relates to a method of controlling or preventing infestations of flies on an animal by applying to the animal a composition comprising an parasiticidally effective amount of a compound of Formula 1, (3-bromo-N-[4-chloro-2-methyl-6-[(methylamino)carbonyl]phenyl]-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide), or an N-oxide, or a salt thereof,08-05-2010
20090291984SUBSTITUTED PYRAZOLES, COMPOSITIONS CONTAINING THESE, METHOD OF PRODUCTION AND USE - The disclosure relates to a compound of formula (1):11-26-2009
20080306120Azaindole inhibitors of aurora kinases - The present invention relates to a compound represented by Formula (I):12-11-2008
20100056582Modulators of LXR - Compounds of the invention, such as compounds of formula (I):03-04-2010
20080312289Use of Cni-Sl Formulations for Controlling White Fly - Method of controlling eggs and nymphal stages of whitefly by the spray application of agrochemical formulations containing at least one insecticide from the series of the neonicotinyls, at least one fatty alcohol ethoxylate of the formula (I), at least one solvent from the group consisting of dimethyl sulphoxide, N-methylpyrrolidone and butyrolactone, and, if appropriate, additives.12-18-2008
20080312287Compound and Methods For the Treatment of Cancer and Malaria - Formula (I): Where R12-18-2008
20100035935ANTHRANILAMIDE COMPOUNDS, PROCESS FOR THEIR PRODUCTION AND PESTICIDES CONTAINING THEM - Anthranilamide compounds, a process for their production, and pesticides containing these compounds as active ingredients. This Abstract is not intended to define the invention disclosed in the specification, nor intended to limit the scope of the invention in any way.02-11-2010
20110201650CYCLOHEXANE DERIVATIVE AND PHARMACEUTICAL USE THEREOF - A compound has a strong analgesic action against both nociceptive pain and neuropathic pain and has less side effects, and is medically useful. The compound includes cyclohexane derivatives represented by the following compound, or pharmaceutically acceptable salts thereof or prodrugs thereof.08-18-2011
20110201649 AGRICULTURAL COMPOSITION - Provided is an agricultural composition comprising a compound represented by the formula (I) or a salt thereof or a hydrate thereof, for controlling a plant disease due to a plant pathogen:08-18-2011
20090149506INSECTICIDAL COMPOSITIONS WITH IMPROVED EFFECT - The present invention relates to increasing the activity of crop protection compositions comprising anthranilic acid diamides through the addition of ammonium salts and/or phosphonium salts or through the addition of ammonium or phosphonium salts and penetrants, to the corresponding compositions, to processes for preparing them and to their use in crop protection.06-11-2009
20100010049Novel Tyrosinase inhibitors and pharmaceutical/cosmetic applications thereof - Compounds corresponding to the following general formula (I):01-14-2010
20110263655METHOD FOR CONTROLLING INSECTS IN PLANTS - The invention relates to a method for controlling woolly apple aphid insect comprising contacting the insect or a locus, where control of the insect is desired, with a combination of at least one neonicotinoid compound and at least one benzoylphenyl urea compound.10-27-2011
20080306119Method for the Protection of Materials - The present invention relates to the use of the compound A) 4-(2,2-difluoro-1,3-benzodioxol-4-yl)pyrrole-3-carbonitrile(fludioxonil) as a microbicide for the protection of engineering or industrial materials, to mixtures containing such compound, and to the use of such mixtures for the protection of engineering or industrial materials.12-11-2008
20100120865Organic compounds - The present invention concerns a compound of formula (I), or a pharmaceutically acceptable salt, or solvate thereof, wherein the groups Ri-Rs are defined in the description, to compositions and use of the compounds in the treatment of diseases ameloriated by inhibition of phosphatidylinositol 3-kinase.05-13-2010
20100010048Fungicide 2-pyridyl-methylene-carboxamide derivatives - The present invention relates to 2-pyridyl-methylene-carboxamide derivatives of formula (I) in which the substituents are as in the description, their process of preparation, their use as fungicide active agents, particularly in the form of fungicide compositions, and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions:01-14-2010
20120035220Method of Fungal Pathogen Control in Grass or Turf - Disclosed is a method of controlling fungal organisms in turfgrass with imidacloprid and optionally one or more other fungicides.02-09-2012
20120108639NITROGEN-CONTAINING AROMATIC HETEROCYCLYL COMPOUND - The present invention provides a compound having excellent regulating action on blood lipid level that is represented by the following general formula (I) or a pharmacologically acceptable salt thereof, wherein, in one embodiment, A represents a 5-membered nitrogen-containing aromatic heterocyclyl group; R05-03-2012
20090143440Pyrazoles Useful in the Treatment of Inflammation - There is provided compounds of formula (I), wherein R06-04-2009
20080207699Pyrazole Derivatives - Compounds of the formula (I), in which R08-28-2008
20090275617Aryl-Substituted Nitrogen-Containing Heterocyclic Compounds - Disclosed is an aryl-substituted nitrogen-containing heterocyclic compound represented by the formula (I) below or a pharmaceutically acceptable salt thereof. This compound serves as nociceptin receptor antagonist and is useful as a pharmaceutical agent for treating diseases associated with a nociceptin receptor. (I)11-05-2009
20090286835NOVEL COMPOUNDS - The present invention provides compounds of formula (I)11-19-2009
20080312290Oil Based Suspension Concentrates - Agrochemical formulation comprising at least one room-temperature-solid active substance from the class of the neonicotinoids, at least one room-temperature-solid active substance from the class of the pyrethroids, at least one penetrant, at least one vegetable oil, cyclohexanone, at least one nonionic surfactant and/or at least one anionic surfactant, and one or more additives, process for producing it, and its use for controlling harmful organisms.12-18-2008
20080280954Method of Improving Wakefulness - The present invention relates to the use of certain imidazolylalkyl-pyridines as wakefulness compounds.11-13-2008
20090030045FACTOR XA INHIBITORS - The present invention is directed to compounds of formula (I) and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of Factor Xa. The present invention is also directed to intermediates used in making such compounds, pharmaceutical compositions containing such a compound, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.01-29-2009
20120196905SYNTHETIC COMPOUNDS AND METHODS TO DECREASE NICOTINE SELF-ADMINISTRATION - Methods and small molecule compounds for smoking and CNS disease harm reduction are provided. One example of a class of compounds that may be used is represented by the compound having the structure IA or IB in the form of free base or a pharmaceutically acceptable salt, hydrate or solvate thereof:08-02-2012
20090182015MICROCAPSULE FORMULATIONS - A method of producing microcapsule formulations wherein slurries containing imidacloprid suspended in water-immiscible organic solvents are wet-crushed, then, urethane-based macromolecular polymers are added to this, and the resultant mixture is dispersed as liquid drops in water, to form membranes on the interfaces of the liquid drops.07-16-2009
20090163554Use of CNI-OD Formulations for Controlling White Fly - Method of controlling eggs and nymphal stages of whitefly by the spray application of oil-based suspension concentrates containing at least one insecticide from the neonicotinyl series, at least one penetrant from the alcohol ethoxylate series, at least one vegetable oil, at least one nonionic surfactant and, if appropriate one or more additives.06-25-2009
20090186924SUBSTITUTED ARYLPYRAZOLES - This invention relates to a range of 1-aryl-4-cyclopropylpyrazoles in which the cyclopropyl ring is substituted at the angular position, and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes to their synthesis and their use as parasiticides.07-23-2009
20090137637Tetrazolyl-Methylene Amino Acid Derivatives - This invention relates to a compound of Formula (I) or a pharmaceutically acceptable salt thereof; a pharmaceutical composition; a method of treating a disease mediated by an MMP-13 enzyme in a mammal; and a therapeutic combination containing at least two pharmaceutically active components, wherein R05-28-2009
20090118336PYRAZOLE DERIVATIVES AND THEIR USE AS PI3K INHIBITORS - The invention concerns pyrazole derivatives of Formula I05-07-2009
20080234329Carboxamide compounds and their use as calpain inhibitors - The present invention relates to novel carboxamide compounds and their use for the manufacture of a medicament. The carboxamide compounds are inhibitors of calpain (calcium dependant cysteine proteases). The invention therefore also relates to the use of these carboxamide compounds for treating a disorder associated with an elevated calpain activity.09-25-2008
20100004293CRYSTALLINE FORMS OF ARYL-SUBSTITUTED PYRAZOLE-AMIDE COMPOUNDS - The present invention provides novel crystals of Compound I, pharmaceutical compositions containing such novel form and a method of treating p38 kinase associated conditions, including rheumatoid arthritis, using such novel form.01-07-2010
20090326012Malononitrile Compounds - Compounds of formula I wherein X is O or S(═O)12-31-2009
20090054492Heterocyclyethylcarboxamide Derivatives - A compound of general formula (I):02-26-2009
20110230525DUAL-ACTING ANTIHYPERTENSIVE AGENTS - In one aspect, the invention relates to compounds having the formula:09-22-2011
20090192198INHIBITORS OF THE 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ENZYME - The present invention relates to inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme and their use in treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome, central nervous system disorders, and diseases and conditions that are related to excessive glucocorticoids.07-30-2009
20080234330Carboxamide compounds and their use as calpain inhibitors - The present invention relates to novel carboxamide compounds and their use for the manufacture of a medicament. The carboxamide compounds are inhibitors of calpain (calcium dependant cysteine proteases). The invention therefore also relates to the use of these carboxamide compounds for treating a disorder associated with an elevated calpain activity.09-25-2008
20080234328ACQUEOUS NEONICOTINOID COMPOSITIONS FOR SEED TREATMENT - An aqueous composition suitable for applying insecticides or acaricides to plant propagation materials comprising water, an insecticidally or acaricidally effective amount of at least one nitroimino- or nitroguanidino-compound in free form or in agrochemically useful salt form and a blend of the following components, by weight:09-25-2008
20080262045Metalloproteinase Inhibitors - Compounds of the formula (I) wherein Z is SO10-23-2008
20080262044Pesticidal Mixtures - The present invention relates to a synergistically effective pesticidal composition which comprises, on the one hand, a bisamide and, on the other hand, known fungicidal active ingredients and which is accordingly very well suited to controlling undesirable animal pests such as insects and acarids and also undesirable phytopathogenic fungi.10-23-2008
20090203745HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF INTEGRINS AND USE THEREOF - The present invention relates to compounds of formula (I) wherein: A is a radical selected from the group comprising aromatic heterocyclic 5-membered ring systems; Ar is a radical selected from the group comprising optionally substituted 5- and 6-membered aromatic ring systems, whereby the ring system contains 0, 1, 2 or 3 heteroatoms selected from the group comprising N, O and S; Z is a linker and Ψ is a radical of formula (II) and their use for the inhibition of integrin.08-13-2009
20090209598Resorcine Derivatives and Their Use as Pesticides - This invention relates to resorcine derivatives of formula (I) wherein R08-20-2009
20090247586CARBOXAMIDES FOR CONTROLLING MICRO-ORGANISMS IN PLANT AND MATERIAL PROTECTION - Novel carboxamides of the formula (I)10-01-2009
20120035221Method of Fungal Pathogen Control in Grass or Turf - Disclosed is a method of controlling fungal organisms in turfgrass with imidacloprid and optionally one or more other fungicides.02-09-2012
20090258910COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS - The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, BCR-Abl, PDGF-R, lck, SAPK2α, p38, TGFβ, KDR, c-Kit, b-RAF, c-RAF, FLT1 and FLT4 kinases.10-15-2009
20080312288SOLID FORMS OF 2-CHLORO-4-[1-(4-FLUORO-PHENYL)-2,5-DIMETHYL-1H-IMIDAZOL-4-YLETHYNYL]-PYRIDINE - The present invention relates to the mono-sulfate salt, crystalline forms A and B of the mono-sulfate salt, an amorphous form of the mono-sulfate salt, hemi-sulfate salts, and a crystalline form A of the hemi-sulfate salt of the compound 2-chloro-4-[1-(4-fluoro-phenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]-pyridine.12-18-2008
20100160383PYRAZOLE CARBOXAMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND ITS PREPARATION - A compound of formula (I) or pharmaceutically acceptable salts and/or solvates or hydrates thereof. A process for preparing the compound, a pharmaceutical composition comprising the compound and an application for resisting cannabinoid CB1 receptor are provided.06-24-2010
20100016373IMIDAZOLE CARBOXAMIDES - The present invention provides certain imidazole carboxamide derivatives, pharmaceutical compositions thereof, methods of using the same and processes for preparing the same.01-21-2010
20100160384DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS - Compounds of the formula I:06-24-2010
20090298887METHOD FOR IMPROVING HARVESTED SEED QUALITY - The present invention is directed to a method for improving the quality of seeds harvested from seed-producing plants. The method comprises treating the pre-planted seeds of the seed-producing plants with a seed treatment insecticide and treating the resulting plant with foliar applications of a foliar insecticide; or treating the pre-planted seeds of the seed-producing plants with a seed treatment insecticide; or treating seed-producing plants with foliar applications of a foliar insecticide.12-03-2009
20110060013THIAZOLES AND PYRAZOLES USEFUL AS KINASE INHIBITORS - The present invention relates to compounds useful as inhibitors of Aurora protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.03-10-2011
20130123306Inhibition of Mitogen-activated Protein Kinases in Cardiovascular Disease - The present invention relates to methods for inhibiting subacute thrombosis and/or intimal hyperplasia following an interventional vascular procedure by contacting a blood vessel or a synthetic material with a mitogen-activated protein kinase (MAPK) pathway inhibitor. The present invention further relates to vascular devices comprising a MAPK pathway inhibitor.05-16-2013
20100152248ISCHEMIC DISORDER OR DISEASE INHIBITORS - The invention relates to the use of at least on inhibitor selected from the group consisting of raf-, protein kinase C(PKC)-, MEK1/2-, or ERK1/2-inhibitors, for the manufacturing of a medicament to be administrated from 1 up to 12 hours after initiation of an ischemic disease.06-17-2010
20100227893INSECTICIDE COMPOSITIONS - Insecticide compositions which comprise one or not less than two kinds of compounds being selected from a compound represented by the formula [I]:09-09-2010
20090076091INDAZOLE-HETEROARYL DERIVATIVES - The invention relates to novel indazole derivatives as cited in claim 03-19-2009
20090076090Treated Expanded Polystyrene Foam - Expanded polystyrene coated with at least one organic pesticide, methods for making expanded polystyrene coated with at least one organic pesticide, and molded articles made from expanded polystyrene coated with at least one organic pesticide is provided herein.03-19-2009
20100144798Modulators of ATP-Binding Cassette Transporters - The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.06-10-2010
20100210690N-(PYRAZOLE-3-YL)-BENZAMIDE DERIVATIVES AS GLUCOKINASE ACTIVATORS - Novel heterocyclic compounds of the formula I08-19-2010
20100210691Compositions for the Control of Plant Pests - The present invention provides a composition comprising imidacloprid and metalaxyl. The compositions of the present invention find use as pesticides.08-19-2010
20100120866PROCESS FOR PRODUCING AMIDE COMPOUND - There is provided a process for producing an amide compound having an excellent harmful arthropod-controlling activity and represented by the formula (III): wherein R05-13-2010
20090253751HYDRAZIDE COMPOUND AND THROMBOPOIETIN RECEPTOR ACTIVATOR - Compounds effective for preventing, treatment or improving diseases against which activation of the thrombopoietin receptor is effective are provided.10-08-2009
200901118571,2,4-TRIAZOLE ETHER DERIVATIVES AS MODULATORS OF MGLUR5 - The present invention is directed to novel compounds, to a process for their preparation, their use in therapy and pharmaceutical compositions comprising the novel compounds.04-30-2009
20090036498FLY CONTROL METHOD - This invention relates to a method of treating myiasis of an animal by applying to the animal a composition comprising an parasiticidally effective amount of a compound of Formula 1, an N-oxide or a pharmaceutically or veterinarily acceptable salts salt thereof02-05-2009
20110021575PENETRATION ENHANCERS FOR INSECTICIDAL AGENTS - Polyalkylene oxide derivates of the formula (I),01-27-2011
20080319023Insecticidal Compositions for Control of General Household Pests - The present invention relates to an insecticidal composition comprising a pyrethroid and a second insecticide selected from the group consisting of imidacloprid, nithiazine, thiamethoxam, dinotefuran, nitenpyram, thiacloprid, clothianidin and chlorfenapyr, with significantly improved knockdown and mortality characteristics when applied to general household pests.12-25-2008
20110034517SELECTIVE SUBTYPE ALPHA 2 ADRENERGIC AGENTS AND METHODS FOR USE THEREOF - The invention provides well-defined heterocyclic compounds that are useful as subtype selective alpha 2 adrenergic agonists. As such, the compounds described herein are useful in treating a wide variety of disorders associated with selective subtype modulation of alpha 2 adrenergic receptors.02-10-2011
20110130427PESTICIDAL COMPOSITION - To improve the controlling effects of anthranilamide compounds against pests. A pesticidal composition comprising, as active ingredients, an anthranilamide compound or its salt, and a polyoxyalkylene phosphoric acid ester surfactant, and a method for controlling a pest by using such a composition, are provided. Further, a method for improving the pesticidal effects of an anthranilamide compound or its salt, as an active ingredient, by means of a polyoxyalkylene phosphoric acid ester surfactant, is provided.06-02-2011
20130190363THERAPEUTIC AGENT FOR NEUROLOGICAL DISEASES - An object of the present invention is to provide a pharmaceutical agent useful for treating and preventing neurological disease, having satisfactory solubility and oxidative stress-mediated cell death suppressive activity as well as capable of exhibiting excellent blood-brain barrier permeability. The present invention is directed to an acylaminoimidazole derivative represented by general formula (I) or a salt thereof, and a pharmaceutical and a therapeutic or preventive agent for neurological disease containing the same, as an active ingredient.07-25-2013
20110086889TETRAZOLE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS - The invention relates to tetrazole compounds of formula (I) wherein X, Y, Z, R04-14-2011
20110086888Fungicidally Active Compound Combinations - The invention relates to novel fungicidallly active compound combinations of 2′-cyano-3,4-dichloroisothiazole-5-carboxanilide of the formula04-14-2011
20090076092METHOD FOR DISRUPTING REPRODUCTIVE PERFORMANCE OF ARTHROPODS - Disclosed is a method for disrupting reproductive performance of an adult arthropod pest comprising contacting the adult arthropod pest or its environment with a sub-lethal, reproduction-disruptive amount of a carboxamide arthropodicide, its N-oxide, or a salt thereof.03-19-2009
20120035222Solid forms of 2-Chloro-4-[1-(4-fluoro-phenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]-pyr- idine - The present invention relates to mono-sulfate and hemi-sulfate salts of 2-Chloro-4-[1-(4-fluoro-phenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]-pyridine, to crystalline and amorphous forms thereof and to their use in pharmaceutical formulations.02-09-2012
20090048306PYRIDINE DERIVATIVES - The present invention relates to compounds of the formula (I):02-19-2009
20090312371SUBSTITUTED ARYLPYRAZOLES - This invention relates to a combination product comprising a range of 1-aryl-4-cyclopropylpyrazoles in which there is at least one fluorine attached to the cyclopropyl ring, and one o more further therapeutic agents, particularly anti-parasitic agents.12-17-2009
20110178133CALCIUM RECEPTOR MODULATING AGENTS - The present invention relates generally to novel calcimimetic compounds and pharmaceutical compositions comprising them. The invention also relates to methods of treating of diseases or disorders related to the function of the calcium sensing receptor using the compounds represented in Formula I.07-21-2011
20090306146Nicotinyls, Pyrethroids, and Ketoenols as a Gel Formation or Foam Formulation for Perennial Cultures - Method of controlling insects with a gel or foam formulation containing at least one insecticidal active substance, characterized in that the agrochemical formulation is applied externally to the trunk of the plant to be protected.12-10-2009
20090215832Method of Combating Turf Pests With a Combination of Imidacloprid and Bifenthrin - This invention relates to a method of controlling surface insect pests of turf using bifenthrin and imidacloprid.08-27-2009
20100069442PYRAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY - Compounds of formula (I), pharmaceutical compositions comprising compounds of formula (I) and methods of inhibiting Hsp90 in a cell, treating or preventing a proliferation disorder in a mammal and treating cancer in a mammal comprising administering a compound of formula (I) to a patient or a cell.03-18-2010
20110152325CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS IV - The present invention relates to novel carboxamide compounds and their use for the manufacture of a medicament. The carboxamide compounds are inhibitors of calpain (calcium dependant cysteine proteases). The invention therefore also relates to the use of these carboxamide compounds for treating a disorder associated with an elevated calpain activity.06-23-2011
20120202853SUBSTITUTED PYRAZOLES AS ESTROGEN RECEPTOR LIGANDS - The invention provides a compound of formula (I) wherein G is a pyrazole ring as defined in the specification and R08-09-2012
20080275092ARYL-SUBSTITUTED PYRAZOLE-AMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS - The present invention relates to compounds having the formula,11-06-2008
20090118335Acid Secretion Inhibitor - The present invention provides a compound having a superior acid secretion inhibitory action, an antiulcer activity and the like.05-07-2009
20110257231ANTHRANILAMIDE COMPOUNDS, PROCESS FOR THEIR PRODUCTION AND PESTICIDES CONTAINING THEM - Anthranilamide compounds, a process for their production, and pesticides containing these compounds as active ingredients. This Abstract is not intended to define the invention disclosed in the specification, nor intended to limit the scope of the invention in any way.10-20-2011
200902475871,3-DIHYDROISOBENZOFURAN DERIVATIVES - The object is to provide a novel LXRβ agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease. The solving means is a 1,3-dihydroisobenzofuran derivative represented by the following general formula (1) or salt thereof, or their solvate.10-01-2009
20100286212Treating and Preventing Viral Infections - Compounds that are useful in treating or preventing viral infections, such as influenza, are described herein. Further described are compositions made from these compounds and methods for using the compounds and their compositions in treating or preventing viral infections.11-11-2010
20100286211OXAZOLIDINONE DERIVATIVES AS ANTIMICROBIALS - The present invention relates to certain substituted phenyl oxazolidinones and to processes for the synthesis of the same. This invention also relates to pharmaceutical compositions containing the compounds of the present invention as antimicrobials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria, for example, multiple-resistant 11-11-2010
20120302609Pyrazolines for the Modulation of PKM2 - The invention relates to pyrazoline substituted compounds and methods for activating PKM2. The compounds and methods are useful in treating or preventing a disease or disorder selected from cancer, cell proliferative disorder, inflammatory disorder, metabolic disorder, and immune system disorder.11-29-2012
20120302608Novel Imidazole Derivatives Useful for the Treatment of Arthritis - The present invention provides compounds of the formula below:11-29-2012
20110077274SUBSTITUTED-ARYL-2-PHENYLETHYL-1H-IMIDAZOLE COMPOUNDS AS SUBTYPE SELECTIVE MODULATORS OF ALPHA 2B AND/OR ALPHA 2C ADRENERGIC RECEPTORS - A compound having selective modulating activity at the alpha 2B and/or alpha 2C adrenergic receptor subtypes is represented by the general Formula 1:03-31-2011
201200715172-PYRIDINYLETHYLCARBOXAMIDE DERIVATIVES AND THEIR USE AS FUNGICIDES - The invention discloses a compound of general formula (I)03-22-2012
20110178135SALTS AND CRYSTALLINE FORMS OF A FACTOR XA INHIBITOR - The present invention provides salts and crystalline forms of the compound 5-chloro-N-((1-(4-(2-oxopyridin-1(2H)-yl)phenyl)-1H-imidazol-4-yl)methyl)thiophene-2-carboxamide, and pharmaceutical compositions and method of use thereof.07-21-2011
20110178134Novel phenyl-substituted imidazolidines, process for preparation thereof, medicaments comprising said compounds and use thereof - The invention relates to compounds of formula (I) wherein the groups have stated meanings, and to their physiologically compatible salts. Said compounds are suitable, for example, as anti-obesity drugs and for treating cardiometabolic syndrome.07-21-2011
20100113530S1P LYASE INHIBITORS FOR THE TREATMENT OF CEREBRAL MALARIA - Methods and compositions for treating, managing, and/or preventing cerebral malaria are disclosed.05-06-2010
20090176844CARBOXAMIDES - Novel carboxamides of the formula (I)07-09-2009
20100022599DUAL-ACTING ANTIHYPERTENSIVE AGENTS - In one aspect, the invention relates to compounds having the formula:01-28-2010
20100022598Substituted inmidazoles as bombesin receptor subtype-3 modulators - Certain novel substituted imidazoles are ligands of the human bombesin receptor and, in particular, are selective ligands of the human bombesin receptor subtype-3 (BRS-3). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of BRS-3, such as obesity, and diabetes.01-28-2010
20100035934PYRIDINYL-PYRAZOLE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS - This invention relates to novel pyridinyl-pyrazole derivatives and their use as potassium channel modulating agents. Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels.02-11-2010
20090203746Synergistic Insecticidal Composition Containing Chloronicotynyle and Pyrethroids Compounds - A synergistic insecticidal composition is formed containing a Chloronicotynyle compound and a Pyrethroids compound. The Chloronicotynyle compound is provided in an amount preferably ranging from 0.1 to 5.0% by weight of the synergistic insecticidal composition. The Pyrethroids compound is provided in an amount preferably ranging from 1 to 60% by weight of the synergistic insecticidal composition. The synergistic insecticidal composition also preferably includes 35 to 98.90% by weight of conventional agriculturally acceptable carrier(s) and/or excipients.08-13-2009
20100137373PESTICIDAL COMPOSITION COMPRISING A STRIGOLACTONE DERIVATIVE AND AN INSECTICIDE COMPOUND - A composition comprising at least a strigolactone derivative (a) of general formula:06-03-2010
20100249193Nematicidal, Insecticidal and Acaricidal Active Ingredient Combinations Comprising Pyridyl-ethylbenzamides and Insecticides - The present invention relates to novel active ingredient combinations which consist of fluopyram and further known active insecticidal ingredients, and are very suitable for controlling animal pests, such as insects and/or unwanted acarids and/or nematodes, in foliar and soil application and/or in seed treatment.09-30-2010
20100099717SUSPENSION CONCENTRATES FOR IMPROVING THE ROOT ABSORPTION OF AGROCHEMICAL ACTIVE INGREDIENTS - It is possible to increase the uptake of active compounds from crop protection compositions using suitable adjuvants, and thus to improve the action of crop protection agents. The present invention describes suitable adjuvants, methods and compositions.04-22-2010
20110306643TRIGLYCERIDE-CONTAINING DORMANCY SPRAYS - There is described a suspension concentrate, containing the following components: 12-15-2011
20110306645Novel ortho-substituted arylamide derivatives - The present invention relates to novel ortho-substituted arylamide derivatives of the general formula (I)12-15-2011
20110306644METALLOENZYME INHIBITOR COMPOUNDS - The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.12-15-2011
20080269299Soil-Wetting Insecticide - A soil-applied composition for controlling turf-damaging pests is an aqueous solution including a neonicotinoid insecticide, such as an imidacloprid-based insecticide, and a nonionic surfactant. The composition may also include a bio-stimulant to aid in turf recovery, a humectant, or both a bio-stimulant and a humectant. An effective amount of the composition may be applied to a region of soil or turf in order to control turf-damaging pests, such as white grubs.10-30-2008
20110086887Oil-Based Suspension Concentrates - The present invention relates to new, oil-based suspension concentrates of active agrochemicals, to a process for producing these formulations and to their use for applying the active substances comprised.04-14-2011
20120010250Anthranilamide derivatives as pesticides - The present invention relates to novel anthranilamide derivatives of the general formula (I)01-12-2012
20120010249Anthranilic diamide derivatives having cyclic side-chains - The present invention relates to novel anthranilic diamide derivatives of the general formula (I)01-12-2012
20100222393MUSCARINIC RECEPTOR ANTAGONISTS - Compounds of Formula (I), wherein represents a single bond when G is —OH and double bond when G is —O; R09-02-2010
20100087492SYSTEMIC TREATMENT OF BLOOD-SUCKING AND BLOOD-CONSUMING PARASITES BY ORAL ADMINISTRATION OF A PARASITICIDAL AGENT - Pharmaceutically acceptable single parasiticidal agent compositions of imidacloprid for oral delivery to mammals to systemically control targeted blood-sucking or blood-consuming parasites, such as fleas, ticks and certain species of helminthes and scabies.04-08-2010
20120157500JAK INHIBITION BLOCKS RNA INTERFERENCE ASSOCIATED TOXICITIES - The instant invention provides a method for treating patients by administering a JAK inhibitor. The instant invention provides a method for treating patients by administering a JAK inhibitor wherein the JAK inhibitor is a JAK2 inhibitor. The instant invention provides a method for treating patients by administering a JAK inhibitor wherein the JAK inhibitor is selected from selected from Jak2-IA, AG490, Pyridone 6, WP1066, LS104, TG101209, TG101348, CP690,550, CP352,664, INCB18424, WHI-P154, CMP6, SB1518, XL019, CEP-701, INCB20, AUH-6-96 and AZ960.06-21-2012
20110034516AMINOPYRAZOLE DERIVATIVES - The invention relates to aminopyrazole derivatives of formula (I),02-10-2011
20110046185Arylchalcogenoarylalkyl-substituted imidazolidine-2,4-diones, process for preparation thereof, medicaments comprising these compounds and use thereof - The invention relates to compounds of formula (I) wherein the groups R and R′ A, D, E, G, L, p and R1 to R10 have the stated meanings and to their physiologically compatible salts. Said compounds are suitable, for example, as anti-obesity drugs.02-24-2011
20090036499FLY CONTROL METHOD - This invention relates to a method of controlling or preventing infestations of flies on an animal by applying to the animal a composition comprising an parasiticidally effective amount of a compound of Formula 1, (3-bromo-N-[4-chloro-2-methyl-6-[(methylamino)carbonyl]phenyl]-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide), or an N-oxide, or a salt thereof,02-05-2009
20120071516COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM - Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.03-22-2012
20120208853PEST CONTROL COMPOSITION - The present invention provides a pest control composition comprising, as active ingredients, an amide compound of the formula (I) [(I) where in R1 and R3 represent, for example, a C1-C6 alkyl group; R2 represent, for example, a Hydrogen atom, a C1-C6 alkyl group; R4 represent, for example, a halogen atom, a C1-C6 alkyl group; R5 represent, for example, a halogen atom, a cyano group; R6 and R7 represent, for example, a halogen atom] and pyriproxyfen; and so on.08-16-2012
201002491941-ARYL-5-ALKYL PYRAZOLE DERIVATIVE COMPOUNDS, PROCESSES OF MAKING AND METHODS OF USING THEREOF - Provided are 1-aryl-5-alkyl pyrazole compounds, of formula (I):09-30-2010
20100093808SALT AND POLYMORPH OF A DPP-IV INHIBITOR - The invention is concerned with (2S)-1-{[1,1-Dimethyl-3-(4-pyridin-3-yl-imidazol-1-yl)-propylamino]-acetyl}-pyrrolidine-2-carbonitrile fumarate and crystalline polymorphs of this compound. This compound and its polymorphic forms exhibits superior properties compared to the previously known compounds and can be used as medicament for the treatment of disorders which are associated with DPP-IV.04-15-2010
20090131484PREVENTIVE OR REMEDY FOR BOWEL DISEASE - [Problem] To provide a preventive or a remedy for various diarrheas caused by inflammatory colitis, irritable bowel syndrome and other factors.05-21-2009
20120129893Inhibition Of Raf Kinase Using Substituted Heterocyclic Ureas - Methods of treating tumors mediated by raf kinase, with substituted urea compounds, and such compounds per se.05-24-2012
20120232117PYRAZOLE DERIVATIVES, PREPARATION METHOD THEREOF, AND COMPOSITION FOR PREVENTION AND TREATMENT OF OSTEOPOROSIS CONTAINING SAME - The present invention provides pyrazole derivative compounds and pharmaceutically acceptable salts thereof. The compounds of the present invention have an excellent effect of preventing and treating osteoporosis.09-13-2012
20120214849DUAL-ACTING ANTIHYPERTENSIVE AGENTS - In one aspect, the invention relates to compounds having the formula:08-23-2012
20120136030COMBINATIONS OF MEK INHIBITORS AND RAF KINASE INHIBITORS AND USES THEREOF - This invention concerns combinations of inhibitors of MEK, Raf protein kinases, and other kinases including VEGFR1-3 and PDGFR-β. This invention also concerns pharmaceutical compositions comprising the compounds described herein and methods of use of the compounds and compositions described herein, including the use in the treatment and/or prevention of cancer and other hyperproliferative disorders.05-31-2012
20100063106AMINOPYRAZOLE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF, AND COMPOSITION FOR PREVENTING OR TREATING ISCHEMIC DISEASES CONTAINING THE SAME - Provided are aminopyrazole derivatives, a process for the preparation thereof, and a composition for preventing or treating an ischemic disease containing the same. Since the aminopyrazole derivatives of the present invention can reduce an ischemic cell death significantly, they can be effectively used for the prevention and treatment of ischemic diseases mediated by ischemic cell death, or protection of organs.03-11-2010
20120136031P38MAP KINASE INHIBITOR - The present invention relates to a compound of formula (I):05-31-2012
20100048639OXADIAZOLE DERIVATES AS S1P1 RECEPTOR AGONISTS - The present invention relates to novel oxadiazole compounds of formula (I)02-25-2010
201002738332-SULFINYL- AND 2-SULFONYL-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR USE AS CYTOKINE INHIBITORS - The invention relates to 2-sulfinyl- or 2-sulfonyl-substituted imidazole derivatives of the formula (I) in which the radicals R10-28-2010
20100010051SUSPENSION CONCENTRATES - The present invention relates to novel suspension concentrates of certain agrochemically active compounds, to a process for preparing these formulations and to their use for applying the active comprised therein.01-14-2010
20100010050FORMULATIONS FOR THE CONTROLLED RELEASE OF AGROCHEMICAL ACTIVE AGENTS - There have been found novel compositions for the controlled release of agrochemical active substances, containing at least one agrochemical active substance, cellulose ester and calcium carbonate.01-14-2010
20120225910Substituted Heteroaryls - The present invention provides Formula (1A) compounds09-06-2012
20090318505FUNGICIDAL COMPOSITIONS - A composition suitable for control of diseases caused by phytopathogens comprising (A) a compound of formula (I) or a tautomer of such a compound; and component (B) and component (C) are pesticides as described in claim 12-24-2009
20090018171IMIDAZOLE DERIVATIVES - The present invention relates to imidazole derivatives of formula I01-15-2009
201100038623-Animopyraolines for Treatment of Neurodegenerative and Psychiatric Diseases - Compounds of the formula (I), inhibit D-amino acid oxidase and hence find use in treating degenerative and psychiatric diseases.01-06-2011
201100461861-Substituted Pyridyl-Pyrazolyl Amide Compounds and Uses Thereof - The present invention discoses a kind of 1-substituted pyridyl-pyrazolyl amide compounds and uses thereof. The compounds have structures as represented by the general formula I, wherein the definitions of each substituent showed in the specification. The compounds of formula I are novel and have excellent insecticidal and fungicidal activities and can be used for controlling insect pest and diseases.02-24-2011
20120270906CYCLOHEXANE DERIVATIVE AND PHARMACEUTICAL USE THEREOF - A method relieves both nociceptive pain and neuropathic pain and has fewer side effects. The compound includes cyclohexane derivatives represented by the following compound, or pharmaceutically acceptable salts thereof or prodrugs thereof.10-25-2012
20120129892NOVEL PHARMACEUTICALLY ACCEPTABLE SALTS OF 4-(1H-IMIDAZOL-4-YLMETHYL)PYRIDINE AND THEIR THERAPEUTICAL USES - The present invention concerns novel pharmaceutical compositions of immethridine, in particular of novel pharmaceutically acceptable salts thereof, such as the dioxalate salt of immethridine, as well as its therapeutical uses and novel process of preparation.05-24-2012
20120088795FACTOR XA INHIBITORS - The present invention is directed to compounds of formula (I) and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of Factor Xa. The present invention is also directed to intermediates used in making such compounds, pharmaceutical compositions containing such a compound, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.04-12-2012
20120088796COMPOUNDS THAT INHIBIT (BLOCK) BITTER TASTE IN COMPOSITION AND USE THEREOF - The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds present in, e.g., coffee. Also, the invention relates to the discovery of specific compounds and compositions containing that function as bitter taste blockers and the use thereof as bitter taste blockers or flavor modulators in, e.g., coffee and coffee flavored foods, beverages and medicaments. Also, the present invention relates to the discovery of a compound that antagonizes numerous different human T2Rs and the use thereof in assays and as a bitter taste blocker in compositions for ingestion by humans and animals.04-12-2012
20100204281ECTOPARASITE CONTROL METHOD - This invention relates to a method of controlling or preventing infestations of ectoparasites, preferably hematophageous ectoparasites, on an animal by administering to the animal a composition comprising an parasiticidally effective amount of a compound of Formula 1, or an N-oxide, or a pharmaceutically or veterinarily acceptable salt thereof,08-12-2010
20110319452CYANO ANTHRANILAMIDE INSECTICIDES - This invention provides compounds of Formula 1, N-oxides and suitable salts thereof12-29-2011
20120101133PROCESS FOR PREPARING TETRAZOLE-SUBSTITUTED ANTHRANILAMIDE DERIVATIVES AND NOVEL CRYSTAL POLYMORPHS OF THESE DERIVATIVES - The present invention relates to a process for preparing tetrazole-substituted anthranilamide derivatives of the formula (I)04-26-2012
20100222394METHOD FOR PRODUCING PYRAZOL-3-YL-BENZAMIDE DERIVATIVE - The present invention provides a more efficient industrial method for producing a pyrazol-3-yl-benzamide derivative expressed by a formula useful as medicine:09-02-2010
20100173949SUBSTITUTED N-PHENYL-BIPYRROLIDINE CARBOXAMIDES AND THERAPEUTIC USE THEREOF - The present invention discloses and claims a series of substituted N-phenyl-bipyrrolidine carboxamides of formula (I).07-08-2010
20100130561CONTROLLING PESTS BY COMBINING INSECTICIDES AND TRANSGENIC PLANTS BY APPLYING DIRECTLY TO LEAVES AND ROOTS - The invention relates to a method for controlling pests using a combination of insecticides and transgenic plants and consequently improving the utilization of the production potential of transgenic plants which comprises treating the plant with active compound combinations comprising an active compound from the group of the anthranilamides and at least one further insecticide.05-27-2010
20110160250CRYSTALLINE FORMS OF A FACTOR XA INHIBITOR - The present invention provides crystalline forms of a mesylate salt of the compound 5-chloro-N-((1-(4-(2-oxopyridin-1(2H)-yl)phenyl)-1H-imidazol-4-yl)methyl)thiophene-2-carboxamide and pharmaceutical compositions and methods thereof.06-30-2011
20080255205Multi-cyclic compounds and methods of use - The present invention relates to compounds of Formulas I and II,10-16-2008
20080255204Agrochemical Formulation for Improving the Action and Plant Compatibility of Crop Protection Agents - The present invention relates to novel agrochemical formulations for treating plants, which formulations comprise, as cosolvent, propylene carbonate, and, if appropriate, further additives, to a process for preparing these formulations and to their use for treating plants and/or their habitat and for increasing the efficacy and plant compatibility of crop protection agents.10-16-2008
20090209597IMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABA ALPHA RECEPTOR COMPLEX - This invention relates to novel imidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith.08-20-2009
20080234331Synergistic Insecticidal Mixtures for the Treatment of Seed - The invention relates to insecticidal mixtures containing, as active substances, at least two compounds from the series of the chloronicotinyl insecticides, and to the use of these mixtures for promoting plant growth.09-25-2008
20080221168N-Thio-Anthranilamid Compounds and Their Use as Pesticides - N-Thio-anthranilamid compounds of Formula (I) wherein is a group selected from A1 and A2 wherein the variables and the indices are as defined per the description, processes for preparing the compounds (I), pesticidal compositions comprising compounds (I), use of compounds (I) for the control of insects, acarids or nematodes, and methods for treating, controlling, preventing or protecting animals against infestation or infection by parasites by use of compounds of Formula (I).09-11-2008
20080221167Selective Insecticides Based on Haloalkylnicotinic Acid Derivatives, Anthranilic Acid Diamides, or Phthalic Acid Diamides and Safeners - The present invention relates to the use of selective insecticidal compositions, characterized by an effective amount of an active compound combination comprising09-11-2008
20130203818COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM - Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.08-08-2013
20130203819APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS - The present invention relates to compounds of Formula (I):08-08-2013
20130143929FUNGICIDAL IMIDAZOLES - Disclosed are compounds of Formula 1, including all stereoisomers, N-oxides, and salts thereof,06-06-2013
20110269800P38 MAP KINASE INHIBITORS - There is provided a compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof, including all tautomers thereof, compositions comprising the same, use of said compound and compositions for treatment, in particular for the treatment of asthma and COPD, and processes for the preparation of said compound.11-03-2011
20130131119N-[(HET)ARYLETHYL)] PYRAZOLE(THIO)CARBOXAMIDES AND THEIR HETEROSUBSTITUTED ANALOGUES - The present invention relates to fungicidal N-[(het)arylethyl)] pyrazolecarboxamide or thiocarboxamide and their heterosubstituted analogues, their process of preparation and intermediate compounds for their preparation, their use as fungicides, particularly in the form of fungicidal compositions and methods for the control of phytopathogenic fungi of plants using these compounds or their compositions.05-23-2013
20130131120THERAPEUTIC AGENT OR PROPHYLACTIC AGENT FOR NEUROPATHIC PAIN - A therapeutic agent or a prophylactic agent for neuropathic pain provides a synergistically-enhanced analgesic effect at a dose at which a calcium channel α2δ ligand does not produce any side effects as well as which agent does not produce any new side effects on the central nervous system. The therapeutic agent or a prophylactic agent for neuropathic pain includes as effective ingredients a cyclohexane derivative, represented by the following formula, or a pharmaceutically acceptable salt thereof or a prodrug thereof, and a calcium channel α2δ ligand.05-23-2013
20080200519TETRAHYDRONAPHTHALENYLAMIDES, A PROCESS FOR THEIR PRODUCTION AND THEIR USE AS ANTI-INFLAMMATORY AGENTS - The present invention relates to the compounds of formula I,08-21-2008
20110224262PYRAZOLYL SUBSTITUTED CARBONIC ACID DERIVATIVES AS MODULATORS OF THE PROSTACYCLIN (PGI2) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO - Pyrazole derivatives of Formula Ia and pharmaceutical compositions thereof that modulate the activity of the PGI2 receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of: pulmonary arterial hypertension (PAH) and related disorders; platelet aggregation; coronary artery disease; myocardial infarction; transient ischemic attack; angina; stroke; ischemia-reperfusion injury; restenosis; atrial fibrillation; blood clot formation in an angioplasty or coronary bypass surgery individual or in an individual suffering from atrial fibrillation; atherosclerosis; atherothrombosis; asthma or a symptom thereof; a diabetic-related disorder such as diabetic peripheral neuropathy, diabetic nephropathy or diabetic retinopathy; glaucoma or other disease of the eye with abnormal intraocular pressure; hypertension; inflammation; psoriasis; psoriatic arthritis; rheumatoid arthritis; Crohn's disease; transplant rejection; multiple sclerosis; systemic lupus erythematosus (SLE); ulcerative colitis; ischemia-reperfusion injury; restenosis; atherosclerosis; acne; type 1 diabetes; type 2 diabetes; sepsis; and chronic obstructive pulmonary disorder (COPD).09-15-2011
20100063107HYDROXY METHYL PHENYL PYRAZOLYL UREA COMPOUNDS USEFULL IN THE TREATMENT OF CANCER - The compound 4-{4-[({3-tert-Butyl-1-[3-(hydroxymethyl)phenyl]-1H-pyrazol-5-yl}carbamoyl)amino]-3-fluorophenoxy}-N-methylpyridine-2-carboxamide and alternative forms thereof (e.g., salts, solvates, hydrates, prodrugs, polymorphs and metabolites); pharmaceutical compositions which contain them; and methods for treating cancer using them.03-11-2010
20100317700PESTICIDAL COMPOSITIONS - To provide a formulation composition which improves the controlling effect of an anthranilamide compound against pests. A pesticide composition which is a concentrated composition containing an anthranilamide compound as a pesticidal active ingredient, a dispersant and a hydrophilic organic solvent, characterized in that when the composition is diluted with water, the anthranilamide compound precipitates as solid particles in water.12-16-2010
20120283298METHODS FOR TREATING MEMORY IMPAIRMENT - Methods for administering a therapeutically effective amount of a somatostatin receptor-4 (SSTR4) agonist in order to treat learning and memory impairment for Alzheimer's disease is disclosed.11-08-2012
20130190362ARTHROPODICIDAL ANTHRANILAMIDES - This invention provides a composition comprising a biologically effective amount of a compound of Formula 1, an N-oxide or an agriculturally suitable salt thereof07-25-2013
20130190364PEST CONTROLLING COMPOSITION AND METHOD FOR CONTROLLING PEST - The present invention provides a composition having an excellent controlling activity on a pest. The composition comprising a compound represented by Formula (1) and one or more diamide compound(s) selected from Group (A) shows an excellent controlling activity on a pest. Group (A): a group consisting of a compound of Formula (2): wherein a combination of R07-25-2013
20120289551MINERALOCORTICOID RECEPTOR ANTAGONISTS - Mineralocorticoid receptor antagonists, of which the following is exemplary.11-15-2012
20120010251PEST CONTROLLING COMPOSITION - The present invention provides a pest controlling composition comprising, as active ingredients, an amide compound of the formula (I) and a pyrethroid compound; and so on.01-12-2012
20120022112USE OF ANTHRANILAMIDE DERIVATIVES FOR CONTROLLING INSECTS AND SPIDER MITES BY DRENCHING, SOIL MIXING, FURROW TREATMENT, DRIP APPLICATION, SOIL, STEM OR FLOWER INJECTION, IN HYDROPONIC SYSTEMS, BY PLANTING HOLE TREATMENT OR DIP APPLICATION, FLOATING OR SEEDBOX APPLICATION OR BY TREATING SEED, AND ALSO FOR ENHANCING THE STRESS TOLERANCE OF PLANTS TO ABIOTIC STRESS - The present invention relates to the use of anthranilamide derivatives of the general formula (I)01-26-2012
20130197037APOPTOSIS SIGNAL-REGULATING KINASE INHIBITOR - The present invention relates to a compound of formula (I):08-01-2013
20120095057PYRAZOLE COMPOUND - Provided is a compound having a superior acid secretion suppressive action, antiulcer activity and the like.04-19-2012
20130210864N-BENZYL HETEROCYCLIC CARBOXAMIDES - The present invention relates to N-benzyl heterocyclic carboxamides derivatives or their thiocarboxamides derivatives, their process of preparation, their use as fungicide, particularly in the form of compositions, and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions.08-15-2013
20130210863SYNERGISTIC INSECTICIDAL MIXTURES - The present invention relates to synergistic insecticidal mixtures comprising a) a Pyrethroid insecticide (preferably bifenthrin), b) a Neonicotinoid insecticide (preferably imidacloprid) and c) a Benzoylphenyl urea insecticide (preferably novaluron) and to the related compositions and methods of controlling insects.08-15-2013

Patent applications in class The additional hetero ring consists of two nitrogens and three carbons