Entries |
Document | Title | Date |
20080262016 | ISOQUINOLINE DERIVATIVES AND METHODS OF USE THEREOF - The invention provides novel classes of Isoquinoline Derivatives. Pharmaceutical compositions and methods of making and using the compounds, are also described. | 10-23-2008 |
20080293757 | ABCA1 ELEVATING COMPOUNDS - The present invention provides compounds useful for increasing cellular ATP binding cassette transporter ABCA1 production in mammals, and to methods of using such compounds in the treatment of coronary artery diseases, dyslipidiemias and metabolic syndrome. The invention also relates to methods for the preparation of such compounds, and to pharmaceutical compositions containing them. | 11-27-2008 |
20090030027 | Androgen Receptor Modulator Compounds and Methods - Provided herein are compounds that bind to androgen receptors and/or modulate activity of androgen receptors, and to methods for making and using such compounds. Also provided are compositions including such compounds and methods for making and using such compositions. | 01-29-2009 |
20090069365 | Tricyclic heteroaryl piperazines, pyrrolidines and azetidines as serotonin receptor modulators - The present invention generally relates to a series of compounds, to pharmaceutical compositions containing the compounds, and to use of the compounds and compositions as therapeutic agents. More specifically, compounds of the present invention are hexahydroazepinoindole and octahydroazepinoindole compounds. These compounds are serotonin receptor (5-HT) ligands and are useful for treating diseases, disorders, and conditions wherein modulation of the activity of serotonin receptors (5-HT) is desired (e.g. anxiety, depression and obesity). | 03-12-2009 |
20090105292 | Glucocorticoid Receptor Modulator Compounds and Methods - Disclosed herein are compounds of Formula I:
| 04-23-2009 |
20090170890 | METHOHDS OF INHIBITING VIRAL INFECTION - A method of inhibiting viral infection in a mammal in need of same, includes administering an effective amount of at least one of the compounds of FGI-103 which are represented by 273, 365 and 510 either prophylactically to prevent viral infection, or therapeutically following viral infection. These compounds appear to selectively inhibit Caspase 8 as a method of preventing infective viral particle release. They can be administered IV, IP, orally or via other conventional administration routes. The compounds are highly effective, requiring relatively low dosages on the order of 1 ng/kg-200 mg/kg of body weight. | 07-02-2009 |
20090197906 | REVERSION OF MALIGNANT PHENOTYPE WITH 9-HYDROXY ELLIPTICINE DERIVATIVES - The invention relates to the use of 9-hydroxy ellipticine derivatives for the treatment of cancer. 9-hydroxy ellipticine derivatives may prove particularly useful for the treatment of metastatic cancers or cancers escaping conventional cytotoxic chemotherapies. | 08-06-2009 |
20090203725 | Androgen Receptor Modulator Compounds and Methods - Provided herein are compounds that bind to androgen receptors and/or modulate activity of androgen receptors and/or modulate the amount of androgen receptors; and to methods for making and using such compounds. Also provided are compositions containing such compounds and methods for making and using such compositions. | 08-13-2009 |
20090264455 | Androgen Receptor Modulator Compounds and Methods - Provided herein are compounds that bind to androgen receptors and/or modulate activity of androgen receptors, and to methods for making and using such compounds. Also provided are compositions including such compounds and methods for making and using such compositions. | 10-22-2009 |
20090312360 | Antineoplastic Combinations Containing HKI-272 and Vinorelbine - A combination of HKI-272 compound and a vinorelbine compound in the treatment of a neoplasm is provided. Regimens, kits, and methods for treatment of neoplasm, including breast cancer including metastatic breast cancer, and lung cancer, using this combination, optionally in combination with other anti-neoplastic agents, or immune modulators are also described. | 12-17-2009 |
20090325997 | Pharmaceutical Compositions For The Treatment Of Capillary Arteriopathy - The present invention relates to the use of ergot derivatives or ergolines, and in particular of lisuride and terguride for the prophylaxis and treatment of constrictive capillary arteriopathy. Constrictive capillary arteriopathy refers to the diseases pulmonary arterial hypertension, endogenously induced or exogenously induced glomeruloscleroses as well as secondary Raynaud's syndrome. | 12-31-2009 |
20100010033 | Bis-carbazole DNA intercalating agents for antitumor therapy - The present invention is a DNA intercalating agent represented by the structure Y-Z-Y, wherein Y is an anti-tumor bis-carbazole and Z is a linear arrangement of multiple aromatic rings, containing at least two aromatic rings, or at least two alicyclic rings, said rings being linked in a 1,4 or 1,3 manner. Methods of inhibiting cancer cells and treating subjects having cancer with these agents are also provided. | 01-14-2010 |
20100022575 | OXYMATRINE COMPOSITIONS AND RELATED METHODS FOR TREATING AND PREVENTING CHRONIC INFECTIOUS DISEASES - Compositions and methods for treating chronic infectious diseases using substantially pure oxymatrine or pharmaceutically acceptable salts or esters thereof are disclosed. In one embodiment described herein, the chronic infectious disease is chronic fatigue syndrome. Further described are compositions having an anti-infective amount of substantially pure oxymatrine or pharmaceutically acceptable salts or esters thereof. | 01-28-2010 |
20100048604 | Ligands for Aldoketoreductases - The present invention relates to compounds useful for detecting the activity of human aldoketoreductase 1Cs, compounds useful for competitively inhibiting human aldoketoreductase 1Cs and compounds useful for treating human aldoketoreductase 1C-related cancers, as well as pharmaceutical compositions and methods of manufacture thereof. | 02-25-2010 |
20100099697 | Method of Treatment Using Inhibitors of Mitosis - Methods of treating diseases caused by cell division or that are treated by inhibiting mitosis by administering two doses of an inhibitor of mitosis between the biologically effective dose and the maximum tolerated dose in a dosing cycle that allows for the recovery or subsiding of side effects, wherein the second dose is administered 24 to 48 hours after the first dose. | 04-22-2010 |
20100120818 | SUBSTITUTED TETRAHYDROPYRROLOQUINOLINES - Compounds of the formula (I), in which R | 05-13-2010 |
20100173927 | BELOXEPIN AND ANALOGS FOR THE TREATMENT OF PAIN - This present disclosure provides methods of treating pain with beloxepin and/or beloxepin analogs. | 07-08-2010 |
20100210678 | Tricyclic androgen receptor modulator compounds and methods - Provided are non-steroidal tricyclic compounds that are modulators of androgen receptors and methods for making and using such compounds. | 08-19-2010 |
20100249171 | ELLIPTICINE COMPOUNDS FOR TREATING OBESITY - The present invention provides a method of reducing body weight in a subject in need thereof, by administering to the subject a therapeutically effective amount of a compound of Formula I: | 09-30-2010 |
20100273823 | Pesticide Composition Solution and Preparation Method Thereof - A pesticide composition solution is provided. The pesticide composition includes an effective amount of active ingredient according to the formula I and a pesticide adjuvant, | 10-28-2010 |
20100286187 | METHOD OF PREDICTING SURVIVAL OF A NON-SMALL-CELL LUNG CANCER PATIENT TO A CHEMOTHERAPEUTIC TREATMENT - Method for predicting the survival of a patient suffering from NSCLC to an antimicrotubule agent based chemotherapy treatment which comprises the step of determining the methylation state of a nucleic acid encoding CHFR in a biological sample from the patient, wherein the presence of methylation is indicative of longer survival of said patient as a response to said chemotherapy treatment. The methylation status of the CHFR gene can be easily determined in a serum sample. | 11-11-2010 |
20100331355 | Substituted Quinolines for the Treatment of Cancer - Compounds of formula G | 12-30-2010 |
20110105552 | BELOXEPIN AND ANALOGS FOR THE TREATMENT OF PAIN - This present disclosure provides methods of treating pain with beloxepin and/or beloxepin analogs. | 05-05-2011 |
20110118295 | METHODS FOR TREATING BOWEL DISEASES - The present invention provides new methods of treating bowel disease (BD) by increasing a durability of response; treating BD in males; treating BD in adolescent subjects; treating bloating due to BD in males; and methods of maintaining remission of BD. | 05-19-2011 |
20110118296 | Bis-Carbazole DNA Intercalating Agents for Antitumor Therapy - The present invention is a DNA intercalating agent represented by the structure Y—Z—Y, wherein Y is an anti-tumor bis-carbazole and Z is a linear arrangement of multiple aromatic rings, containing at least two aromatic rings, or at least two alicyclic rings, said rings being linked in a 1,4 or 1,3 manner. Methods of inhibiting cancer cells and treating subjects having cancer with these agents are also provided. | 05-19-2011 |
20110269790 | NOVEL THIENOPYRIDINES AS PHARMACOLOGICALLY ACTIVE AGENTS - The present invention provides compounds and pharmaceutically acceptable salts thereof methods for synthesizing thienopyridines and methods for inhibiting TNF-α activity for the treatment of cancer, asthma, arthritis, diabetes and inflammation. Provided are compounds of formula (I). | 11-03-2011 |
20120041017 | PYRIDOCARBAZOLE TYPE COMPOUNDS AND APPLICATIONS THEREOF - Pyridocarbazole-type compounds of formula (I): | 02-16-2012 |
20120108623 | BELOXEPIN AND ANALOGS FOR THE TREATMENT OF PAIN - This present disclosure provides methods of treating pain with beloxepin and/or beloxepin analogs. | 05-03-2012 |
20120129882 | Method for producing benzazoloquinolium (BQs) salts, using the composition as cellular markers, and using the biological activity of the composition - A synthesis procedure for benzazolo[3,2-a]quinolinium chloride salts and the inclusion of chloro-substituent, amino-substituent, and nitro-substituent resulting in several compounds wherein said procedures provides an increment in the compounds biological activity. The compounds are further used for intra cellular binding, cytotoxicity on malignant cells through apoptosis activation mediated by mitochondrial damage, cellular organelles binding and damage, DNA fragmentation, marker of bacterial growth, antibacterial activity, cell cycle disruption, and a marker due to the auto-fluorescent properties. | 05-24-2012 |
20120165362 | Androgen receptor modulator compounds and methods - Provided herein are compounds that bind to androgen receptors and/or modulate activity of androgen receptors, and to methods for making and using such compounds. Also provided are compositions including such compounds and methods for making and using such compositions. | 06-28-2012 |
20120316192 | SUBSTITUTED INDOLO [2,3-A] QUINOLIZINES - The present invention relates to novel substituted indolo[2,3-a]quinolizines and stereoisomeric forms thereof and/or pharmaceutically acceptable salts of these compounds as well as pharmaceutical compositions containing at least one of these substituted indolo[2,3-a]quinolizines together with pharmaceutically acceptable carrier, excipient and/or diluents. Said novel substituted indolo[2,3-a]quinolizines have been identified as useful for the prophylaxis and treatment of cancer by the induction of strong mitotic delays, chromosomal misalignments and mitotic tri- and multipolarization leading to cell cycle stop and apoptosis. Furthermore a synthesis for preparation of the substituted indolo[2,3-a]quinolizines is disclosed in the present invention. | 12-13-2012 |
20130158063 | Compounds, Compositions and Methods Related to PPAR Antagonists - Disclosed are compounds, compositions and methods related PPAR antagonists. Certain compounds are effective at inhibiting PPARs. The compositions can be used to inhibit PPARs, treat cancer and treat metabolic disorders. | 06-20-2013 |
20150018380 | Methods of Screening for Activation Deaminase Inhibitors Through Nuclear Import Inhibitors - The present invention provides methods for obtaining specific and non-toxic inhibitors of AID nuclear import. The methods comprise a primary screen and a counter screen to identify a pool of AID specific nuclear import inhibitors that do not have off-target of toxic effects. AID specific nuclear import inhibitors identified by the screens of the invention prevent nuclear entry, limit the access of AID to genomic DNA, and inhibit AID mutagenic activity. Preparations, including pharmaceutical preparations, comprising specific nuclear import inhibitors, used for example, to inhibit cancer progression, are also encompassed in the invention. | 01-15-2015 |