Class / Patent application number | Description | Number of patent applications / Date published |
514259200 | Ring chalcogen in the bicyclo ring system | 22 |
20080242682 | Preventive or Therapeutic Agent for Sleep Disorder - A combination of (S)—N-[2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethyl]propionamide with a medicine capable of prolonging a slow-wave sleep time provides a preventive or therapeutic agent for sleep disorder that induces natural sleep, shortens sleep latency, increases deep sleep, excels in sleep maintenance and ensures an appropriate sleep time. | 10-02-2008 |
20090176808 | COMBINATION OF A SEROTONIN REUPTAKE INHIBITOR AND A 5-HT2C ANTAGONIST, INVERSE AGONIST OR PARTIAL AGONIST - The present invention relates to the use of compounds and compositions of compounds having serotonin reuptake inhibiting activity and 5-HT | 07-09-2009 |
20090286811 | FUSED PYRIMIDINEONE COMPOUNDS AS TRPV3 MODULATORS - The present invention provides transient receptor potential vanilloid (TRPV) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPV3. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPV3. | 11-19-2009 |
20100075994 | SUBSTITUTED DIHYDRO AND TETRAHYDRO OXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF - The present invention relates to a series of substituted dihydro and tetrahydro oxazolopyrimidinones, specifically, to a series of 2-substituted-2,3-dihydro-oxazolo[3,2-a]pyrimidin-7-ones and 2-substituted-2,3,5,6-tetra-hydro-oxazolo[3,2-a]pyrimidin-7-ones of formula (I): | 03-25-2010 |
20100216819 | Thiazolopyrimidines for Use in Therapy - Use of a compound of formula (I) wherein R is an alicyclic group; an arylethyl group; or phenyl or benzyl substituted by halogen, lower alkyl, alkoxy, OH, NH | 08-26-2010 |
20110015212 | PYRIMIDINONES AS PI3K INHIBITORS - The present invention provides pyrimidinones that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PI3Ks including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases. | 01-20-2011 |
20120115886 | FUSED PYRIMIDINEONE COMPOUNDS AS TRPV3 MODULATORS - The present invention provides transient receptor potential vanilloid (TRPV) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPV3. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPV3. | 05-10-2012 |
20120184566 | SUBSTITUTED DIHYDRO BENZOCYCLOALKYLOXYMETHYL OXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF - The present invention relates to a series of substituted dihydro benzocycloalkyl-oxymethyl oxazolopyrimidinones of formula (I): | 07-19-2012 |
20130165453 | THERAPEUTIC EFFECTS OF BRYOSTATINS, BRYOLOGS, AND OTHER RELATED SUBSTANCES ON ISCHEMIA/STROKE-INDUCED MEMORY IMPAIRMENT AND BRAIN INJURY - The invention provides for the use of protein kinase activators or boosters of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) or other neurotrophic factors to treat stroke. Specifically, the present invention provides methods of treating stroke comprising the steps of identifying a subject having suffered a stroke and administering to said subject an amount of a pharmaceutical composition comprising a protein kinase C (PKC) activator or 4-methylcatechol acetic acid (MCBA) and a pharmaceutically acceptable carrier effective to treat at least one symptom of stroke. | 06-27-2013 |
20130281466 | ARTHROPOD PEST CONTROL COMPOSITION AND METHOD FOR CONTROLLING ARTHROPOD PESTS - Disclosed is an arthropod pest control composition having an excellent controlling effect on arthropod pests, which comprises a compound represented by formula (I): | 10-24-2013 |
20130289051 | ARTHROPOD PEST CONTROL COMPOSITION AND METHOD FOR CONTROLLING ARTHROPOD PESTS - Disclosed is an arthropod pest control composition having an excellent controlling effect on arthropod pests, which comprises a compound represented by formula (I) | 10-31-2013 |
20130289052 | ARTHROPOD PEST CONTROL COMPOSITION AND METHOD FOR CONTROLLING ARTHROPOD PESTS - Disclosed is an arthropod pest control composition having an excellent controlling effect on arthropod pests, which comprises a compound represented by formula (I): | 10-31-2013 |
20140024659 | N-substituted hetero-bicyclic compounds and derivatives for combating animal pests - The invention relates to N-substituted hetero-bicyclic compounds of formula (I), to the enantiomers, diastereomers and salts thereof and to compositions comprising such compounds. The invention also relates to methods and uses of these N-substituted hetero-bicyclic compounds, and of compositions comprising thereof, for combating and controlling animal pests. Furthermore the invention relates also to pesticidal methods of applying such N-substituted hetero-bicyclic compounds. | 01-23-2014 |
20140080842 | SMALL MOLECULE INHIBITORS OF TRPA1 - The present invention relates to the use of compounds which are capable of attenuating skin irritation when they are applied to the skin. Skin irritation can be caused, inter alia, by ingredients of cosmetic or pharmaceutical compositions and/or environmental irritants. In particular, the present invention relates to compounds having the property of antagonizing the activation of the transient receptor potential (TRP) ankyrin 1 (TRPA1) ion channel and the use of said compounds as soothing agents. Such compounds can be used in many fields, particularly in personal-care products, cosmetics, textile and packaging products, pharmaceutical compositions, medical devices, and foodstuffs. The present invention further relates to products and/or pharmaceutical compositions containing said compounds. The present invention also relates to the use of the compounds described herein for the modulation of the taste of a food product. | 03-20-2014 |
20140121222 | PYRIMIDINONES AS PI3K INHIBITORS - The present invention provides pyrimidinones that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PI3Ks including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases. | 05-01-2014 |
20140142120 | METHOD OF TREATING CANCER WITH MODULATORS OF SCFSkp2 - The present invention relates to pharmaceutical compositions comprising a compound and a pharmaceutically acceptable carrier. The present invention is also directed to a method of treating cancer in a subject. Also disclosed are methods of inhibiting SCF-Skp2 activity and a method of identifying inhibitors of SCF-Skp2 activity. | 05-22-2014 |
20140378475 | SUBSTITUTED TETRAHYDROCARBAZOLE AND CARBAZOLE CARBOXAMIDE COMPOUNDS - Disclosed are compounds of Formula (I) | 12-25-2014 |
20150313903 | METHODS OF TREATING COGNITIVE IMPAIRMENT ASSOCIATED WITH NEURODEGENERATIVE DISORDERS - Methods of treating cognitive impairment, and/or reducing or preventing one or more neuropsychiatric morbidities in a subject with a neurodegenerative disease or disorder are disclosed. The methods can include administering the subject an effective amount of a (1-piperidinylalkyl)pyrimidinone derivative, preferably ritanserin, or a pharmaceutically acceptable salt thereof, to increase slow wave sleep; to increase dopamine signaling, preferably in the brain, more preferably in the prefrontal cortex; to increase the expression of BDNF preferably in the brain, more preferably in the hippocampus; or a combination thereof. Typically, the compound is administered in a pharmaceutical composition including a pharmaceutically acceptable carrier or excipient. In some embodiments, the subject has not been clinically diagnosed with neurodegenerative disease based on physical symptoms. | 11-05-2015 |
20160075669 | CYCLOPHILIN D INHIBITORS - A compound that can function as a Cyclophilin D can include a structure of Formula 1 or Formula 2 or Formula 3 or Formula 4 or Formula 5 or Formula 6 or Formula 7 or Formula 8, derivative thereof, prodrug thereof, salt thereof, or stereoisomer thereof, or having any chirality at any chiral center, or tautomer, polymorph, solvate, or combination thereof, as presented herein. The Cyclophilin D inhibitors can inhibit onset or treat neurodegenerative disease, such as Alzheimer's disease, or can be used for inhibiting progression or treating diabetes. | 03-17-2016 |
20160120801 | USE OF A THIAZOLO PYRIMIDINONE FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASE - Present invention relates to a low dose pharmaceutical composition, preferably oral composition comprising therapeutically effective amount of [(2-hydroxy-4-oxo-6,7,8,9-tetrahydro-4H,5H-10-thia-1,4a-diaza-benzo[a]azulene-3-carbonyl)-amino]-acetic acid (compound A) in the range of 2.5 mg to 60 mg. Present invention also relates to a method of treating inflammatory bowel disease in a mammal by administrating said low dose pharmaceutical composition. Further, present invention relates to a use of the compound A for the preparation of low dose pharmaceutical composition for the treatment of inflammatory bowel disease in a mammal. | 05-05-2016 |
20160194338 | SUBSTITUTED TETRAHYDROCARBAZOLE AND CARBAZOLES CARBOXAMIDE COMPOUNDS | 07-07-2016 |
20160200710 | CARBAZOLE CARBOXAMIDE COMPOUNDS | 07-14-2016 |