Entries |
Document | Title | Date |
20080293744 | Enantiomers of Selected Fused Pyrimidones and Uses in the Treatment and Prevention of Cancer - This invention relates to novel compounds having the structural formula (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment or prophylaxis of cancer. | 11-27-2008 |
20080318979 | DERIVATIVES OF 4-(N-AZACYCLOALKYL) ANILIDES AS POTASSIUM CHANNEL MODULATORS - This invention provides potassium channel modulators which are compounds of formula I | 12-25-2008 |
20090062311 | MACROCYLIC INHIBITORS OF HEPATITIS C VIRUS - Inhibitors of HCV replication of formula (I) | 03-05-2009 |
20090143411 | Thiophens and Their Use as Anti-Tumor Agents - The present invention provides novel compounds and pharmaceutical compositions thereof, as well as methods for using the compounds and pharmaceutical compositions for treating tumors. Examples of specific tumor types that the compounds may be used to treat include, but are not limited to sarcomas, melanomas, neuroblastomas, carcinomas (including but not limited to lung, renal cell, ovarian, liver, bladder, and pancreatic carcinomas), and mesotheliomas. | 06-04-2009 |
20090170877 | 5,6-Trimethylenepyrimidin-4-one compounds - Pyrimidone compounds of formula (I): | 07-02-2009 |
20090170878 | MACROCYCLIC COMPOUNDS USEFUL AS BACE INHIBITORS - The invention relates to novel macrocyclic compounds of the formula | 07-02-2009 |
20090281120 | BICYCLIC HETEROCYCLIC COMPOUND - A compound represented by the formula (I), a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof: | 11-12-2009 |
20100081674 | FUSED HETEROCYCLIC DERIVATIVE, PHARMACEUTICAL COMPOSITION COMPRISING THE DERIVATIVE, AND USE OF THE COMPOSITION FOR MEDICAL PURPOSES - The present invention provides compounds useful as agents for the prevention or treatment of a sex hormone-dependent disease or the like. That is, the present invention provides fused heterocyclic derivatives represented by the following general formula (I) which has a GnRH antagonistic activity, pharmaceutical compositions containing the same, medicinal uses thereof and the like. In the formula (I), rings A is 5-membered cyclic unsaturated hydrocarbon or 5-membered heteroaryl; R | 04-01-2010 |
20110046162 | FUSED CYANOPYRIDINES AND THE USE THEREOF - The present application relates to novel substituted fused cyanopyridine derivatives, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, preferably for the treatment and/or prevention of cardiovascular disorders. | 02-24-2011 |
20110053959 | PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS - The present invention provides compounds of Formula (I) including tautomers, resolved enantiomers, resolved diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as Akt protein kinase inhibitors and for the treatment of Akt-mediated diseases, for example, hyperproliferative diseases such as cancer. | 03-03-2011 |
20110172249 | METHOD FOR IMPROVING ABSORBABILITY OF PREPARATION, AND PREPARATION HAVING IMPROVED ABSORBABILITY - The present invention provides a method for improving absorbability of the active ingredient of an enteric polymer coated preparation, which includes using an organic acid. | 07-14-2011 |
20110178105 | CLINICAL BENEFITS OF EICOSAPENTAENOIC ACID IN HUMANS - Methods are provided for maintaining or lowering lipoprotein-associated phospholipase A | 07-21-2011 |
20120028994 | COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION - The present disclosure provides a series of compounds of the formula (I) | 02-02-2012 |
20120035190 | E-type Phenyl Acrylic Ester Compounds Containing Substituted Anilino Pyrimidine Group and Uses Thereof - Disclosed is a kind of E-type phenyl acrylic ester compound containing substituted anilino pyrimidine group, which is shown by general structure formula I, wherein each substituent is defined as that in the description. The compounds of general formula I show high insecticidal and acaricidal activities to adults and nymphs of harmful insects and mites in agricultural, civil and zoic technical fields, especially to | 02-09-2012 |
20120172378 | NOVEL COMPOUNDS - Pyrimidone compounds of formula (I): | 07-05-2012 |
20130030011 | COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION - The present disclosure provides a series of compounds of the formula (I) | 01-31-2013 |
20130072500 | PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS - The present invention provides compounds of Formula I including tautomers, resolved enantiomers, resolved diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. | 03-21-2013 |
20130150379 | METHODS OF TREATMENT AND PREVENTION OF NEURODEGENERATIVE DISEASES AND DISORDERS - The present invention provides compostions and methods useful for treating and preventing neurodenerative disease and neurologically related disorders by inhibition of Lp-PLA2. The compositions and methods are useful for treating and preventing diseases and disorders with abnormal blood brain barrier (BBB) function, for example neurodegenerative diseases with a permeable BBB, such as but not limited to, Alzheimer's Disease, Huntington's Disease, Parkinson's Disease and Vascular Dementia. | 06-13-2013 |
20130225608 | SUBSTITUTED PYRIMIDINE AMMONIA COMPOUNDS AND USES THEREOF - The invention relates to substituted pyrimidine ammonia compounds. The structure of the compounds is represented as the general formula (I): | 08-29-2013 |
20140107135 | PYRIMIDINONE INHIBITORS OF LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 - The present invention relates to new pyrimidinone inhibitors of lipoprotein-associated phospholipase A2 activity, pharmaceutical compositions thereof, and methods of use thereof. | 04-17-2014 |
20140303188 | Substituted Cyclopenta Pyrimidine Bicyclic Compounds Having Antitmitotic And/Or Antitumor Activity And Methods Of Use Thereof - The present invention provides substituted cyclopenta and cyclopentyl pyrimidine bicyclic compounds of Formula III, | 10-09-2014 |
20150045375 | NOVEL COMPOUNDS - Pyrimidone compounds of formula (I): | 02-12-2015 |
20150335019 | SYNERGISTIC COMBINATION OF A LENACIL COMPOUND AND ONE OF DCOIT OR OIT FOR DRY FILM PROTECTION - A synergistic antimicrobial composition containing lenacil and one of 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one or 2-n-octyl-4-isothiazolin-3-one is provided. Also provided is a method of inhibiting the growth of or controlling the growth of microorganisms in a building material by adding such a synergistic antimicrobial composition. Also provided is a coating composition containing such a synergistic antimicrobial composition, and a dry film made from such a coating composition. | 11-26-2015 |
20150352116 | HDAC INHIBITOR AND BTK INHIBITOR COMBINATIONS - Disclosed herein are methods and compounds for treating an individual diagnosed with chronic lymphocytic leukemia (CLL) or acute myeloid leukemia (AML) by administering to the individual a combination comprising ibrutinib and Abexinostat. Also provided are methods for treating an ibrutinib-resistant CLL or an ibrutinib-resistant AML by administering to the individual a combination comprising ibrutinib and Abexinostat. Further provided are methods of reducing the development of ibrutinib resistance in an individual having either CLL or AML or preventing the development of ibrutinib resistance in an individual having CLL or AML by administering to the individual a combination comprising ibrutinib and Abexinostat. | 12-10-2015 |
20160031829 | SUBSTITUTED BICYCLIC DIHYDROPYRIMIDINONES AND THEIR USE AS INHIBITORS OF NEUTROPHIL ELASTASE ACTIVITY - Substituted bicyclic dihydropyrimidinones of formula 1 | 02-04-2016 |
20160031830 | SUBSTITUTED BICYCLIC DIHYDROPYRIMIDINONES AND THEIR USE AS INHIBITORS OF NEUTROPHIL ELASTASE ACTIVITY - Substituted dihydropyrimidinones of formula 1 | 02-04-2016 |
20160060230 | SUBSTITUTED BICYCLIC DIHYDROPYRIMIDINONES AND THEIR USE AS INHIBITORS OF NEUTROPHIL ELASTASE ACTIVITY - This invention relates to substituted bicyclic dihydropyrimidinones of formula 1 | 03-03-2016 |