Entries |
Document | Title | Date |
20090030014 | Indole Derivative Having Pgd2 Receptor Antagonist Activity - The present invention creates an indole derivative having DP receptor antagonistic activity and a pharmaceutical composition comprising the said compound as an active ingredient, and further a therapeutic agent for treating allergic diseases. | 01-29-2009 |
20090069343 | Combination Histamine H1R and H4R Antagonist Therapy for Treating Pruritus - Patients suffering from pruritus or itch may be effectively treated by administering a centrally acting histamine H1 receptor antagonist (e.g., diphenhydramine, triprolidine, hydroxyzine, pyrilamine, promethazine, or chlorpheniramine) and a histamine H4 receptor antagonist (e.g., 5-chloro-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone). | 03-12-2009 |
20090143406 | New Phenylpiperazine - The invention relates to a novel group of phenylpiperazines having interesting pharmacological properties such as a high affinity for the dopamine D | 06-04-2009 |
20090186906 | Furo[3, 2-b] pyrrol derivatives - The present invention relates to compounds of formula (I), and pharmaceutically acceptable salts thereof, wherein: R | 07-23-2009 |
20090192170 | Furo[3,2-B] pyrrol -3-one derivatives and their use as cysteinyl porteinase inhibitors - The present invention relates to compounds of formula (I), and pharmaceutically acceptable salts thereof (I), wherein: R | 07-30-2009 |
20090203714 | Furo[3,2-B]pyrrol-3-one derivatives and their use as cysteinyl proteinase inhibitors - The present invention relates to compounds of formula (I), and pharmaceutically acceptable salts thereof, | 08-13-2009 |
20090270414 | 2,3,4,9- TETRAHYDRO-1H-CARBAZOLE DERIVATIVES AS CRTH2 RECEPTOR ANTAGONISTS - The invention relates to novel tetrahydro-1H-carbazole derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and methods of treatment comprising administration of said compounds to patients. | 10-29-2009 |
20090298849 | Materials and Methods Relating to the Induction of Apoptosis in Target Cells - Compositions, methods, uses and assemblages for the preferential induction of cell division cycle arrest and/or apoptosis, in a first population of cells compared to a second population of cells employ either: (i) an opioid or opioid-like agent and an NF-κB activating agent, which agents are other than the opioid-like agent trans-U50488 in combination with an NF-κB activating agent selected from etoposide and nocodazole; (ii) a ligand for a sigma receptor, or (iii) an opioid or opioid-like agent wherein the cells of the first population are other than tumour cells. | 12-03-2009 |
20100010009 | Furo[3,2-B] pyrrol -3-one derivatives and their use as cysteinyl porteinase inhibitors - The present invention relates to compounds of formula (1), and pharmaceutically acceptable salts thereof, A compound of formula (I), or a pharmaceutically acceptable salt, hydrate, complex or pro-drug thereof (I), wherein: one of R | 01-14-2010 |
20100041673 | 5-(HETEROCYCLYL)ALKYL-N-(ARYLSULFONYL)INDOLE COMPOUNDS AND THEIR USE AS 5-HT6 LIGANDS - Compounds including 5-(Heterocyclyl)alkyl-N-(arylsulfonyl)indole, their derivatives, their stereoisomers, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them and a process for the preparation of these compounds, their derivatives, their stereoisomers, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them. These compounds are useful in the treatment of various disorders that are related to 5-HT6 receptor functions. Specifically, the compounds of this invention are also useful in the treatment of various CNS disorders, hematological disorders, eating disorders, diseases associated with pain, respiratory diseases, genito-urological disorders, cardiovascular diseases and cancer. | 02-18-2010 |
20100113476 | CHEMICAL LINKERS WITH SINGLE AMINO ACIDS AND CONJUGATES THEREOF - The present disclosure provides drug-ligand conjugates that are potent cytotoxins and include a linker between the drug and ligand where the linker has a single amino acid. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them. | 05-06-2010 |
20100216811 | FURO[3. 2-B] PYRROL DERIVATIVES - The present invention relates to compounds of formula (I), and pharmaceutically acceptable salts thereof, wherein: R | 08-26-2010 |
20100222363 | Bicyclic Derivatives as P38 Inhibitors - New bicyclic derivatives of formula (I); wherein the meanings for the various substituents are as disclosed in the description. These compounds are useful as p38 kinase inhibitors. | 09-02-2010 |
20100273812 | DIAZO BICYCLIC SMAC MIMETICS AND THE USES THEREOF - The invention relates to diazo bicyclic mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis. | 10-28-2010 |
20100292249 | MANUFACTURE OF RIMCAZOLE - The present invention relates to a process for preparing Rimcazole and its salts. | 11-18-2010 |
20110046155 | HYDROBENZAMIDE DERIVATIVES AS INHIBITORS OF HSP90 - The invention provides an acid addition salt of a compound of the formula (1) Also provided by the invention are processes for preparing the compound of formula (1) and alkyl analogues thereof, novel intermediates for use in the process and methods for preparing the intermediates. The invention also provides new medical uses of compounds of the formula (1) and its ethyl analogue. | 02-24-2011 |
20110077254 | COMPOUNDS - A compound of formula (I), or a pharmaceutically acceptable salt, hydrate, complex or pro-drug thereof, | 03-31-2011 |
20110288104 | Beta-3 receptor ligands and their use in therapy - The present invention relates to new compounds, ligands of the beta-3 adrenergic receptor, their preparation and their use in therapy or as research tools for said receptor; the invention also relates to a process for the preparation of the compounds of the invention and the use of inverse agonists of the beta-3 adrenergic receptor as medicaments. | 11-24-2011 |
20110294823 | TREATMENT OF POST-TRAUMATIC STRESS DISORDER WITH TETRAHYDROINDOLONE ARYLPIPERZAINE COMPOUNDS - Tetrahydroindolone and aryl piperazine derivatives for use in treating post-traumatic stress disorder and acute stress disorder. | 12-01-2011 |
20120035187 | ANTI-NEURODEGENERATIVE DISEASE AGENT - The present invention has an object to provide a novel agent for anti-neurodegenerative diseases and solves the object by providing an agent for anti-neurodegenerative diseases containing, as an effective ingredient, the compound(s) represented by the following General formula 1: | 02-09-2012 |
20140057924 | BIVALENT INHIBITORS OF IAP PROTEINS AND THERAPEUTIC METHODS USING THE SAME - Inhibitors of IAP proteins and compositions containing the same are disclosed. Methods of using the IAP protein inhibitors in the treatment of diseases and conditions wherein inhibition of IAP proteins provides a benefit, like cancers, also are disclosed. | 02-27-2014 |
20140221394 | HYDROBENZAMIDE DERIVATIVES AS INHIBITORS OF HSP90 - The invention provides an acid addition salt of a compound of the formula ( | 08-07-2014 |
20140275114 | SUBSTITUTED 2-AZA-BICYCLO[2.2.1]HEPTANE-3-CARBOXYLIC ACID (CYANO-METHYL)-AMIDES INHIBITORS OF CATHEPSIN C - This invention relates to 2-Aza-bicyclo[2.2.1]heptane-3-carboxylic acid (cyano-methyl)-amides of formula 1 | 09-18-2014 |
20150018369 | Compositions and Methods for Treating Malignant Astrocytomas - The disclosure provides methods of treating glioblastoma, methods of screening for compounds that treat glioblastoma, and pharmaceutical compositions useful in the treatment of glioblastoma. | 01-15-2015 |