Entries |
Document | Title | Date |
20080234283 | Glutathione peroxidase mimetics for treatment of neurodegenerative, pulmonary and inflammatory diseases - This invention relates to compositions and methods for the treatment of neurodegenerative, pulmonary and inflammatory diseases described herein with glutathione peroxidase and its mimetics. | 09-25-2008 |
20080255137 | N-Biaryl and N-Arylheteroaryl 2-Substituted Piperazine Derivatives as Modulators of the 5ht2c Receptor Useful for the Treatment of Disorders Related Thereto - The present invention relates to certain N-biaryl and N-arylheteroaryl 2-substituted piperazine derivatives of Formula (Ia) that are modulators of the 5HT2C receptor. Accordingly, compounds of the present invention are useful for the treatment of 5HT2C receptor associated diseases or disorders, such as, obesity, Alzheimer Disease, erectile dysfunction and related disorders. | 10-16-2008 |
20080287454 | CXCR4 ANTAGONISTS - The present invention is drawn to novel antiviral compounds, pharmaceutical compositions and their use. More specifically this invention is drawn to derivatives of monocyclic polyamines which have activity in standard tests against HIV- or FIV-infected cells as well as other biological activity related to binding of ligands to chemokine receptors that mediate a number of mammalian embryonic developmental processes. | 11-20-2008 |
20080318970 | Treatment of Infectious Diseases - The present invention is directed to the use of chemosensitising compounds, in particular thioxanthene derivatives and phenothiazine derivatives, for treatment of infectious diseases in combination with an anti-infective agent. The invention furthermore relates to compositions comprising said chemosensitising compounds and anti-infective agents. | 12-25-2008 |
20090062297 | Hydroxyalkylarylamide Derivatives - The present invention relates to a novel class of hydroxyalkylarylamide derivatives. The instant compounds can be used to treat cancer. The fluorinated arylamide derivatives can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the hydroxamic acid derivatives and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the hydroxamic acid derivatives in vivo. | 03-05-2009 |
20090069335 | Guanidine-containing compounds useful as muscarinic receptor antagonists - The invention provides compounds of formula I: | 03-12-2009 |
20090076019 | METHODS FOR TREATING NEUROLOGICAL DISORDERS OR DAMAGE - A clonogenic neurosphere assay is described that carries out high throughput screens (HTS) to identify potent and/or selective modulators of proliferation, differentiation and/or renewal of neural precursor cells, neural progenitor cells and/or self-renewing and multipotent neural stem cells (NSCs). Compositions comprising the identified modulators and methods of using the modulators and compositions, in particular to treat neurological disorders (e.g. brain or CNS cancer) or damage are also disclosed. | 03-19-2009 |
20090099193 | EML4-ALK FUSION GENE - The present inventors found that a fusion gene present in some cancer patients is an oncogene. The present invention relates to a polypeptide as a novel fusion protein, a polynucleotide encoding the polypeptide, a vector comprising the polynucleotide, a transformed cell comprising the vector, and a therapeutic agent for cancer. | 04-16-2009 |
20090176795 | Enhanced delivery of antifungal agents - Tetrahydrofuran antibiotics formulated with certain diacylglycerol-poltethyleneglycol (DAG-PEG) lipids have increased water solubility and bioavailabilty. PEG-12 GDO, PEG-12 GDLO, PEG-12 GDM and PEG-12 GDP are particularly suitable for forming liposomes that incorporate tetrahydroflurans in the bilayer. | 07-09-2009 |
20090247536 | Bissulfonamide Compounds As Agonists Of GalR1, Compositions, And Methods Of Use - Embodiments of the present invention provide bissulfonamide compounds that are agonists of GalR1. The present invention further provides compositions comprising bissulfonamide compounds that are agonists of GalR1, and methods of use of such compounds and compositions. | 10-01-2009 |
20090318462 | PROTEIN KINASE C ZETA INHIBITION TO TREAT VASCULAR PERMEABILITY - Methods of treating or preventing a disease or disorder in a subject are provided by the present invention which include administering a composition including a therapeutically effective amount of a protein kinase C (PKC) zeta inhibitor. A disease or disorder treated or prevented by administration of a PKC zeta inhibitor is characterized by abnormal vascular permeability. Diseases or disorders treated or prevented by administration of a composition including a therapeutically effective amount of a PKC zeta inhibitor include cancer, an ischemic condition and microvascular complications of a systemic or local condition in the subject, such as diabetes and/or diabetic macular edema. Additionally, methods of inhibiting PKC zeta are provided which include incubating PKC zeta in vivo, in vitro and/or in silico with a PKC zeta inhibitor. | 12-24-2009 |
20100160337 | SULFAMIDES AS TRPM8 MODULATORS - Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: | 06-24-2010 |
20100210662 | INDOL-2-ONE DERIVATIVES DISUBSTITUTED IN THE 3-POSITION, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF - The present invention relates to 3-disubstituted indol-2-one derivatives, to their preparation and to their therapeutic application. | 08-19-2010 |
20100286162 | HUMAN PAPILLOMA VIRUS INHIBITORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME - HPV inhibitors of formula (I) in which G | 11-11-2010 |
20110190310 | Hypoxia Activated Drugs Of Nitrogen Mustard Alkylators - Hypoxia activated drug compounds having a structure of formula (I) are useful in the treatment of cancer and other hyperproliferative diseases. | 08-04-2011 |
20110245264 | Modulators of G Protein-Coupled Receptor 88 - The present disclosure is generally directed to compounds which can modulate G-protein coupled receptor 88, compositions comprising such compounds, and methods for modulating G-protein coupled receptor 88. | 10-06-2011 |
20110245265 | CXCR4 ANTAGONISTS FOR KIDNEY INJURY - Methods to treat or prevent acute kidney injury and chronic kidney injury in subjects using CXCR4 antagonists are disclosed. | 10-06-2011 |
20120101107 | PIPERAZINE DITHIOCTATE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME - The present invention relates to piperazine dithioctate, a novel addition salt of thioctic acid with a base and a pharmaceutical composition comprising the same. The piperazine dithioctate according to the present invention has good thermal and moisture stability and high water-solubility as well as dosage increase lower than other addition salts, thereby being effectively used for preparing a pharmaceutical composition for antioxidation or for preventing or treating diabetic polyneuropathy, etc. | 04-26-2012 |
20120122880 | THIOXANTHENE DERIVATIVES FOR THE TREATMENT OF INFECTIOUS DISEASES - The claimed subject matter is directed to certain thioxanthene derivatives and phenothiazine derivatives suitable for use as anti-infective agents, in particular, for the treatment of infectious diseases. The claimed subject matter furthermore relates to compositions including said anti-infective agents. | 05-17-2012 |
20130261130 | NEUROTRYPSIN INHIBITORS - The invention relates to acylamino-phthalic acid amides and related compounds of formula (I) wherein A is —CON—R | 10-03-2013 |
20140066451 | THIOXANTHENE DERIVATIVES FOR THE TREATMENT OF INFECTIOUS DISEASES - The claimed subject matter is directed to certain thioxanthene derivatives and phenothiazine derivatives suitable for use as anti-infective agents, in particular, for the treatment of infectious diseases. The claimed subject matter furthermore relates to compositions including said anti-infective agents. | 03-06-2014 |
20140275103 | Compositions, formulations and methods for treating ocular diseases - Disclosed herein are compounds effective for activation of Tie-2 and inhibition of HPTP-beta. The compounds can provide effective therapy for conditions associated with angiogenesis, for example, ocular conditions. Formulations for increased solubility are disclosed. Combination therapy with antibodies and PK/PD data are also disclosed. | 09-18-2014 |
20150368210 | 2-AMINOPYRAZINE DERIVATIVES AS CSF-1 R KINASE INHIBITORS - The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt, N-oxide, hydrate or solvate thereof: wherein: ring A, R | 12-24-2015 |
20160115539 | USE OF A SLC MAMMALIAN SKIN TRANSPORTER - A method of using a Solute Carrier (SLC) mammalian skin transporter is described for evaluating the penetration of topical drug. Also described, are methods of using the transporter to diagnose skin diseases and to treat skin diseases. | 04-28-2016 |