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506 - Combinatorial chemistry technology: method, library, apparatus

506033000 - APPARATUS SPECIALLY ADAPTED FOR USE IN COMBINATORIAL CHEMISTRY OR WITH A LIBRARY

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DocumentTitleDate
20110195871SYSTEMS AND METHODS OF SCREENING BIOMARKERS IN BODILY FLUIDS - Systems and methods of screening biomarkers in bodily fluids. According to at least one embodiment of the system for analyzing stabilizing agents of the present disclosure, the system comprises a detection platform comprising a plurality of detection sites each capable of receiving a diagnostic marker, a stabilization agent, and a detection agent. The system, in at least one embodiment, further comprises a detection device capable of determining a binding characteristic between the detection agent and the diagnostic marker in the detection sites. Further, the system may also be able to compare the binding characteristic among a plurality of detection markers to order the level of effect of the stabilizing agents assayed on the binding characteristic between the detection agent and the diagnostic agent.08-11-2011
20110195873SYSTEMS AND METHODS FOR THE DETECTION OF BIOMARKERS - Systems and methods for the detection of biomarkers. In at least one embodiment of a microarray system of the present disclosure, the microarray system comprises a microarray product comprising at least 100 diagnostic markers/cm08-11-2011
20110195872DEVICES AND SYSTEMS FOR BIOMARKER DETECTION - Devices and systems for biomarker detection . In at least one embodiment of a diagnostic testing device of the present disclosure, the device comprises a fluid collector to collect a body fluid, and a housing, to test and retain the body fluid. The housing, in at least one embodiment, comprises a collection chamber, having an open end, to receive the fluid collector and contain a stabilization reagent, at least one membrane test strip, to indicate the presence or absence of at least one diagnostic marker, and an immunoassay-based fingerprint acquisition pad in fluid communication with the collection chamber.08-11-2011
20130079253MICROARRAY-BASED SAMPLE ANALYSIS SYSTEM - A microarray-based sample analysis (MBSA) system includes a cartridge holder adapted to receive a replaceable cartridge that is configured to receive a detachable, replaceable sample analysis unit containing one or more reaction chambers for sample analysis; a fluid control subsystem that controls fluid flow; and an optical subsystem configured to capture an image of the microarray.03-28-2013
20130079254Microfluidic dialysis device - A microfluidic dialysis device that has a first channel for receiving a biological sample, a second channel, and a series of adjacent channels extending between the first channel and the second channel. Each of the adjacent channels pin a meniscus of the sample that arrests capillary flow between the first channel and the second channel. A bypass channel between the first channel and the second channel, the bypass channel joining the second channel upstream of the adjacent channels and is configured for uninterrupted capillary driven flow from the first channel to the second channel. Flow from the bypass channel reaches the meniscus pinned at each of the adjacent channels after the meniscus has formed to sequentially remove each of the menisci and allow flow from the first channel to the second channel via the adjacent channels as well as the bypass channel.03-28-2013
20100323926DIAGNOSIS DEVICE AND METHOD OF MANUFACTURING THE DIAGNOSIS DEVICE - Provided are a diagnosis device in which a bio-chemical reaction between a reference sample and a target sample occurs and a result of the bio-chemical reaction can be detected and a method of manufacturing the diagnosis device. The diagnosis device includes an image sensor where a plurality of photo-detectors are formed; a polymer layer which is made of a polymer material and formed on an upper portion of the image sensor; and a plurality of wells which are formed corresponding to the plurality of photo-detectors on the polymer layer, wherein an inner portion of each well is empty.12-23-2010
20100041571Multiplexed Lateral Flow Assay Arrays - A diagnostic test device comprising at least one membrane disposed in any of one, two, and three dimensions; at least one test sample fluid input port that receives and transfers at least one test sample fluid and onto the at least one membrane; at least one contiguous fluid flow manifold within the at least one membrane to multiplex or distribute the at least one test sample fluid; at least one contiguous fluid flow channel that operatively connects the at least one membrane to the at least one contiguous fluid flow manifold; at least one analyte assay test zone disposed within the at least one contiguous fluid flow channel; and at least one chemical capturing reagent disposed within the at least one analyte assay test zone, wherein multiple analyte assay test results are simultaneously obtained and in parallel in the diagnostic test device.02-18-2010
20100105578METHOD AND DEVICE FOR MEASURING MULTIPLE PHYSIOLOGICAL PROPERTIES OF CELLS - A method of analyzing cells disposed in media within a vessel includes the steps of providing a vessel having an original volume of media about the cells, reducing the original volume of media about at least a portion of the cells to define a reduced volume of media, and analyzing a constituent related to the cells within the reduced volume of media. An apparatus for analyzing cells includes a stage adapted to receive a vessel holding cells and a volume of media, a plunger adapted to receive a barrier to create a reduced volume of media within the vessel including at least a portion of the cells, the barrier adapted for insertion into the vessel by relative movement of the stage and the plunger, and a sensor in sensing communication with the reduced volume of media, wherein the sensor is configured to analyze a constituent disposed within the reduced volume.04-29-2010
20100105577PASSIVE MICROFLUIDIC ARRAY CARD AND READER - A microfluidic array card and reader system for analyzing a sample. The microfluidic array card includes a sample loading section for loading the sample onto the microfluidic array card, a multiplicity of array windows, and a transport section or sections for transporting the sample from the sample loading section to the array windows. The microfluidic array card reader includes a housing, a receiving section for receiving the microfluidic array card, a viewing section, and a light source that directs light to the array window of the microfluidic array card and to the viewing section.04-29-2010
20100331219TEMPERATURE CONTROLLER FOR STRUCTURE - A temperature controller for controlling temperature of a first structure having a first flat face comprises a second structure having a second flat face for planar contact with the first flat face, a pressure-applying means for pressing the first structure, a second supporting means for supporting the second structure to be capable of changing inclination of the second flat face, a first supporting means for supporting the first structure by contact with a portion of the first structure other than the first flat face, and a temperature-controlling means, wherein the first structure is supported by pressing the first structure by the pressure-applying means, and the second structure is brought into contact with the temperature-controlling means with interposition of the second supporting means.12-30-2010
20090042743METHOD FOR DETERMINING CRYSTALLIZATION PARAMETERS AND APPARATUS FOR USE WITH THE SAME - The present disclosure provides a method to allow a user to pre-screen numerous crystallization conditions in the crystallization space to identify those conditions with the highest probability of yielding crystals and high quality diffracting crystals. In one embodiment, the dilute solution thermodynamic virial coefficient, termed B, is used to aid in the determination crystallization conditions that increase the probability of producing crystals for the crystallant of interest. The present disclosure also provide methods for predicting solution conditions that generate beneficial solubility and/or stability conditions for a polypeptide of interest using the B parameter. Devices for use in the described methods are also described.02-12-2009
20080300148MICROFLUIDIC DEVICE FOR SIMULTANEOUSLY CONDUCTING MULTIPLE ANALYSES - Provided is a rotatable microfluidic device for conducting simultaneously two or more assays. The device includes a platform which can be rotated, a first unit which is disposed at one portion of the platform and detects a target material from a sample using surface on which a capture probe selectively binds to the target material is attached, and a second unit which is disposed at another portion of the platform and detects a target material included in the sample by a different reaction from the reaction conducted in the first unit.12-04-2008
20090075843Biological Sensor System - Disclosed is a system using each of the descrete emitters in a III-nitride micro-emitter array as a light source for measuring the properties of independent samples of biological materials deposed on a micro-array using some form of detecting device, e.g, a detector array or charge-coupled device. In embodiments the emitter array produces deep ultraviolet in investigating protein-protein interactions or to detect biological and chemical molecules with high specificity by monitoring changes in a protein's intrinsic fluorescence.03-19-2009
20130065797AUTOMATED SAMPLE HANDLING INSTRUMENTATION, SYSTEMS, PROCESSES, AND METHODS - The present invention provides a processing station for automatically processing a biological sample, a system for automated real-time inventory control of consumables within a biological sample handling or assay instrument, a high throughput random access automated instrument for processing biological samples, an automated instrument for processing or analysis of a sample, and processes for automated mucoid detection and elimination. Methods of using the disclosed instruments, mucoid detection processes, and systems to process and/or analyze samples are also disclosed.03-14-2013
20110046021TAG FREE BIO SENSING MICRO STRIP - In one embodiment, a system for determining information about an assay incorporates a filter assembly that includes an optical structure configured to be removably attachable to a laser resonating cavity of the system, the optical structure being configured to form a portion of the laser resonating cavity such that it reflects light propagating through a gain medium in the laser resonating cavity when attached thereto. The optical structure can include a first surface having an array of one or more sites, each site containing an assay, and a second surface configured such that the second surface is disposed within the laser resonating cavity forming a portion of the laser resonating cavity. The optical structure is configured to optically interact with the assay to change one or more characteristics of light in the laser resonating cavity based on a reaction that occurs in an assay on said first surface.02-24-2011
20120115757SELF-SENSING ARRAY OF MICROCANTILEVERS FOR CHEMICAL DETECTION - The invention provides a chemical detection system for detecting at least one target chemical species, including a self-sensed cantilevered probe array having a plurality of self-sensed cantilevered probes, at least one chemical-sensitive coating material applied to at least one cantilevered probe in the cantilevered probe array, and an interface circuit that is coupled to the cantilevered probe array. At least one cantilevered probe in the cantilevered probe array exhibits a shifted cantilevered probe response when the cantilevered probe array is exposed to the target chemical species and the interface circuit actuates the cantilevered probe. A handheld chemical detection system and a method of operation are also disclosed.05-10-2012
20110028353BIOCHEMICAL REACTION CASSETTE - A biochemical reaction cassette having a structure for uniformizing a liquid flow in a reaction chamber with a simple additional arrangement is provided. A fluid resistive section is arranged in a channel that is constructed to include an injection port, a reaction chamber, and a discharge port. The fluid resistive section decreases the cross-sectional area of the channel to decrease the fluid resistance at ends in the width direction of the fluid resistive section and at positions remote from the injection port and the discharge port, where the flow rate is decreased.02-03-2011
20110281775DETECTION AND/OR QUANTIFICATION METHOD OF TARGET MOLECULES ON A SOLID SUPPORT - The present invention relates to a method and device for detecting and/or quantifying one or multiple target molecules present in a solution by quantifying online their binding on specific capture molecules immobilized at different locations (spots) of a surface of an optically transparent solid support without substantial detection of target molecules present in solution. The present invention allows multiple target assays to be performed in a simultaneous detection. More particularly, the invention comprises detecting in real-time the hybridization between capture DNA molecules present on a micro-array and target polynucleotides present in solution. The invention is also related to real-time PCR of multiple targets on a micro-array.11-17-2011
20110287980LASER MODIFICATION AND FUNCTIONALIZATION OF SUBSTRATES - Assay devices comprising substrates functionalized to comprise probe species on multiple separate regions are provided. Ten thousand to a hundred thousand separate regions can be provided in a substrate of one square centimeter. The separate regions can comprise separate probe species, or in another embodiment, multiple different probe species can be present on each single functionalized region. The probe species are selected to be specific for binding to target species of interest in a sample. Methods and systems for making these devices are also provided. The devices are useful, for example for assaying molecules in a human sample that are reactive to a large number of different allergens placed on the substrate.11-24-2011
20110287981METHODS AND SYSTEMS FOR SIMULTANEOUS REAL-TIME MONITORING OF OPTICAL SIGNALS FROM MULTIPLE SOURCES - Methods and systems for real-time monitoring of optical signals from arrays of signal sources, and particularly optical signal sources that have spectrally different signal components. Systems include signal source arrays in optical communication with optical trains that direct excitation radiation to and emitted signals from such arrays and image the signals onto detector arrays, from which such signals may be subjected to additional processing.11-24-2011
20090036328BIOCHIP PACKAGE AND BIOCHIP PACKAGING SUBSTRATE - A biochip package allowing biochips optimized for high-volume production to be compatible with general-purpose devices and a biochip packaging substrate of the biochip package are provided. The biochip package can include a biochip having a probe array mounted thereon and a biochip packaging substrate on which the biochip is mounted and which has a through cavity exposing a rear surface of the biochip.02-05-2009
20110201530Vacuum Assist For a Microplate - A vacuum assist apparatus can comprise a microplate. The microplate can comprise a first surface and an opposing second surface. A plurality of wells can be formed in the first surface of the microplate. Each of the plurality of wells can be sized to receive an assay therein. A support base can comprise a fluid passage. The microplate can be positioned adjacent and in contact with the support base. A pressure device, in fluid communication with the fluid passage, can exert a vacuum within the fluid passage to actively retain the microplate in the contact with the support base.08-18-2011
20090143250MICROFLUIDIC DEVICE USING MICROFLUIDIC CHIP AND MICROFLUIDIC DEVICE USING BIOMOLECULE MICROARRAY CHIP - Disclosed is a microfluidic device including a microfluidic structure formed in a platform in which various examinations, such as an immune serum examination, can be automatically performed using the biomolecule microarray chip. The biomolecule microarray chip-type microfluidic device using a biomolecule microarray chip comprises: a platform which is rotatable; a microfluidic structure disposed in the platform, comprising: a plurality of chambers; a plurality of channels connecting the chambers each other; and a plurality of valves controlling flow of fluids through the channels, wherein the microfluidic structure controls flow of a fluid sample using rotation of the platform and the valves; and a biomolecule microarray chip mounted in the platform such that biomolecule capture probes bound to the biomolecule microarray chip contact the fluid sample in the microfluidic structure.06-04-2009
20100099582Biochip Package Structure - A biochip package structure is provided. The biochip package structure includes a substrate, a biochip, at least one wire, and a molding compound. The substrate has a circuit unit electrically connected, by wiring, to the biochip defined with a sensing region. The molding compound covers the wire but leaves the sensing region of the biochip exposed, allowing a cavity to be formed in the sensing region. The cavity delivers a biomedical sample. The biomedical sample reacts in the sensing region. Thus, the biochip package structure is applicable to various medical and biochemical assays.04-22-2010
20100099583OPTICAL DETECTING APPARATUS FOR A BIO-CHIP - An optical detecting apparatus for a bio-chip, the optical detecting apparatus including: a light source system for illuminating a bio-chip with an excitation light; a fluorescent light detecting system for detecting a fluorescent light emitted by the bio-chip; and a light path altering unit for directing the excitation light emitted by the light source system to a bio-chip and directing the fluorescent light emitted by the bio-chip to the fluorescent light detecting system, wherein a cross-sectional area of the excitation light irradiated by the light source system onto the bio-chip is greater than an area of the bio-chip, and the fluorescent light detecting system detects a fluorescent image of the entire bio-chip with a single illumination of excitation light.04-22-2010
20110172129Biochip Having Image Sensor with Back Side Illumination Photodiode - A biochip having an image sensor with a back side illumination photodiode structure includes: a biochip layer; and an image sensor layer attached to one surface of the biochip layer and configured to sense light with biochemical reaction information, which is emitted from the biochip layer, wherein the image sensor layer includes a plurality of light sensing parts which receive the light directed toward a back side of a wafer.07-14-2011
20110269649ACTIVE NEMS ARRAYS FOR BIOCHEMICAL ANALYSES - A biofunctionalized nanoelectromechanical device (BioNEMS) for sensing single-molecules in solution by measuring the variation in the mechanical displacement of the BioNEMS device during a binding event is provided. The biofunctionalized nanoelectromechanical device according to the invention generally comprises a nanomechanical mechanical resonator, a detector integral with the mechanical resonator for measuring the mechanical displacement of the resonator, and electronics connected to the detector for communicating the results to a user. A system of biofunctionalized nanoelectromechanical devices and a method for utilizing the biofunctionalized nanoelectromechanical device of the present invention are also provided.11-03-2011
20100248995MICROREACTOR - A microreactor with at least one cavity, which comprises a bottom, a side wall and an opening disposed opposite the bottom, has a cross-section intersecting the side wall parallel to the bottom, the cross-section having a shape diverging from a round, square or rectangular shape.09-30-2010
20080269078Nanoscale array biomolecular bond enhancer device - The invention teaches the use of an addressable nanoscale device to create a programmable substrate useful in selectively attracting proteins, nucleating protein crystals and growing protein crystals of a size amenable to diffraction analysis. Further taught is the use of nanoscale assemblies to create charge patterns, where such charge patterns are useful in purifying, nucleating or crystallizing protein molecules. Charge extension moieties, including water, are taught. The invention provides rapid and efficient identification, purification and detection of proteins and protein-related complexes.10-30-2008
20100137166INDEPENDENTLY REMOVABLE NUCLEIC ACID SEQUENCING SYSTEM AND METHOD - A technique for sequencing nucleic acids in an automated or semi-automated manner is disclosed. Sample arrays of a multitude of nucleic acid sites are processed in multiple cycles to add nucleotides to the material to be sequenced, detect the nucleotides added to sites, and to de-block the added nucleotides of blocking agents and tags used to identify the last added nucleotide. Multiple parameters of the system are monitored to enable diagnosis and correction of problems as they occur during sequencing of the samples. Quality control routines are run during sequencing to determine quality of samples, and quality of the data collected.06-03-2010
20110269648ELECTROCHEMICAL SENSOR SYSTEM - A electrochemical sensor system is provided. An example system utilizes electrical and steric properties of contaminants, such as pesticides, herbicides, and heavy metals to measure an ongoing concentration of multiple contaminants simultaneously in real time. An example system has a sensor array including sensors tuned to specific contaminants, each sensor having at least two conducting elements arranged in a capacitive relationship, for example, on a printed circuit board. A binding layer on the conducing elements of each sensor selectively binds a specific contaminant, which produces a signature change in a measureable electrical property, such as impedance. Enclosed sensors and chemical buffers preserve the chemical and physical environment of the contaminants for ongoing real-time measurement of dynamic concentrations. A delivery system enables samples containing contaminants to be automatically delivered to the array of sensors without adulterating the natural state of the samples.11-03-2011
20090029877Automated System for Isolating, Amplifying, and Detecting a Target Nucleic Acid Sequence Present in a Fluid Sample - An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, performing an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. The analyzer further includes devices for carrying a plurality of specimen tubes and disposable pipette tips in a machine-accessible manner, a device for agitating containers of target capture reagents comprising suspensions of solid support material and for presenting the containers for machine access thereto, and a device for holding containers of reagents in a temperature controlled environment and presenting the containers for machine access thereto. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte. The process is performed by automatically moving each of a plurality of reaction receptacles containing a solid support material and a fluid sample between stations for incubating the contents of the reaction receptacle and for separating the target analyte bound to the solid support from the fluid sample. An amplification reagent is added to the separated analyte after the analyte separation step and before a final incubation step.01-29-2009
20090005270Systems and Methods for Evaluating Enzyme Competency - The present invention provides systems and methods for determining enzymatic competency, which is important in determining whether a patient may suffer an adverse drug reaction, has a disease associated with defects in specific enzymatic function, and/or has an enzyme defect that is likely to cause pathophysiology. As contemplated herein, a parent molecular entity is administered to a patient in whom enzymatic competency is to be determined. A sample of the patient's bodily fluid is exposed to a sensor of the invention to distinguish, detect, and quantify a detectable entity in the bodily fluid. Sensor-acquired data regarding the detectable entity is used to determine enzymatic competency. Preferably, a sample of a patient's exhaled breath is collected and exposed to the sensor of the invention. Types of sensor systems of the invention include, but are not limited to, surface resonance arrays; microelectromechanical sensors (such as microcantilever-based technology); molecularly imprinted polymer sensors; amplifying fluorescent sensor technology; aptamer-based sensor technology; SAW sensors; infrared sensors; fuel cells; chemical reactors; and pH sensitive sensors.01-01-2009
20090186780Biochip - A biochip for qualitatively analyzing a biological sample using probes includes a probe cell array comprising a plurality of probe cells capable of coupling with biomolecules of a biological sample, an optical sensor for detecting optical signals from probe cells selectively coupling with the biomolecules of the biological sample and converting the optical signals to digital electrical signals, and a memory cell array for storing the digital electrical signals.07-23-2009
20080234144Apparatus and method for digital magnetic beads analysis - A micro bead having a digitally coded structure that is partially transmissive and opaque to light. The pattern of transmitted light is determined by to decode the bead. The coded bead may be structured a series of alternating light transmissive and opaque sections, with relative positions, widths and spacing resembling a 1D or 2D bar code image. To decode the image, the alternating transmissive and opaque sections of the body are scanned in analogous fashion to bar code scanning. The coded bead may be coated or immobilized with a capture or probe to effect a desired bioassay. The coded bead may include a paramagnetic material. A bioanalysis system conducts high throughput bioanalysis using the coded bead, including a reaction detection zone and a decoding zone. Alternative method for barcode determination is based on barcode pattern image processes. Microbeads can also be settled down to the bottom of the well in a microplate, so the barcode can be decoded by image processed directly. Therefore, multiple-analyte tests can be performed in one single well. Microplate is a standard format; each plate can have 96, 384, or 1536 patient samples. The bead image is taken with a conventional microscope and optical detector from the bottom of an optically clear microplate, and barcode pattern can be decoded by image software. Therefore, the whole bead experiment can be performed in the microplate without taking the beads out.09-25-2008
20090023610Removable microfluidic cell - A microfluidic flow cell for removably interfacing with a removable-member for performing a reaction therebetween. The microfluidic flow cell device comprises at least one reaction portion defining with the removable-member a reaction chamber when in an interfaced position thereof. The microfluidic flow cell comprises at least one fluid-receiving portion for receiving a fluid therein and being in fluid communication with the reaction chamber. When the microfluidic flow cell and the removable-member are in the interfaced position, the cell is adapted to allow for the fluid in the fluid-receiving portion to flow to the reaction chamber. Devices, systems and methods comprising this microfluidic flow cell are also disclosed.01-22-2009
20090062152THERMAL CYCLING APPARATUS AND METHOD - A thermal cycling device and a method of thermal cycling are provided. A thermal cycling device includes a fluid device system, a case, and a cycling head. The fluid delivery system develops a flow of controlled-temperature fluid. The case has a fluid-tight cavity for holding a microfluidic array. The array includes a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces. The cycling head holds the case and delivers the flow of fluid over the case.03-05-2009
20110143968SAMPLE VESSELS - A sample vessel may include a segmented tubule and an interface receiving the tubule. The segmented tubule may include an opening for receiving a sample material and at least one compressible section, the at least one compressible section having a wall constructed at least partially from a material having sufficient flexibility to permit compression of opposed sections of the wall into contact with one another, and at least two segments of the tubule being fluidically isolated from one another by a bonding of a fluid-tight seal between opposed sections of the tubule wall, wherein said fluid-tight seal irreversibly opens upon application of fluid pressure greater than a threshold value to permit selective fluid communication between the opposed sections. The interface may facilitate delivery of a sample material to the tubule through the opening.06-16-2011
20090062151COMPUTERIZED METHOD AND APPARATUS FOR ANALYZING AMINO ACIDS - A method for analyzing a plurality of amino acids in a fluid sample by a user is provided comprising the steps of introducing the sample into a buffer solution, passing the sample in the buffer solution through a separation column and setting a lithium ion concentration in the buffer to no more than 0.3 mols/L up to a time before β-aminoisobutyric acid (β-AiBA) is eluted.03-05-2009
20090054267Active nems arrays for biochemical analyses - A biofunctionalized nanoelectromechanical device (BioNEMS) for sensing single-molecules in solution by measuring the variation in the mechanical displacement of the BioNEMS device during a binding event is provided. The biofunctionalized nanoelectromechanical device according to the invention generally comprises a nanomechanical mechanical resonator, a detector integral with the mechanical resonator for measuring the mechanical displacement of the resonator, and electronics connected to the detector for communicating the results to a user. A system of biofunctionalized nanoelectromechanical devices and a method for utilizing the biofunctionalized nanoelectromechanical device of the present invention are also provided.02-26-2009
20090054266Microfluidic transfer pin - A liquid dispenser for a microfluidic assay system is described. The dispenser includes at least one transfer pin for transferring a microfluidic sample of liquid to a target receptacle. A pin tip at one end of the transfer pin is structured to cooperate with an opening in the target receptacle. The tip uses capillary action to transfer the sample from the pin to the receptacle.02-26-2009
20090105096Filter-Equipped Microplate - There is provided a filter-equipped microplate including: an upper container 04-23-2009
20090105095Device for Studying Individual Cells - A device for studying individual cells including a picowell array (such as an array of microwells, dimples, depressions, tubes or enclosures) and a fluid reservoir in fluid communication with the picowells through channels is disclosed. Preferably, the device has a moveable lid that in one rest location allows loading of cells in the picowell array. Preferably the channels of the device are capillary channels.04-23-2009
20100160184CROSS TYPE MAGNETIC ARRAY SENSORS FOR BIOMOLECULES MAGNETIC BEAD DETECTION - There is provided a cross-type magnetic array sensor for biomolecules magnetic bead detection having a structure of various types, which can be used as a high-sensitivity and high-density magnetic biosensor. Since a vertical output voltage vertically crossing an applied current direction can be measured, it is possible to measure high-sensitivity magnetic-field variation in comparison with a known magnetic bead detection device that measures an output voltage parallel to the applied current direction. As a result, a magnetic bead magnetic-field detection device having a high signal-to-noise ratio can be achieved. Further, since the cross-type magnetic array sensors for biomolecules magnetic bead detection measure a vertical voltage, magnetic beads can be magnetized by an applied current induction magnetic field that is generated by an applied current without a magnetic field applied from the outside.06-24-2010
20120196775EMISSION INTENSITY MEASURING DEVICE - An emission intensity measuring device includes a light receiving unit that is disposed opposed to a biochip having a plurality of compartments in which a sample is housed, and includes a plurality of light receiving elements that are arranged, and a determining section that determines a weighting rate of each of the light receiving elements based on a noise characteristic of the light receiving element, acquired in advance. The emission intensity measuring device further includes a multiplying section that multiplies the output of each of the light receiving elements by the weighting rate to calculate a weighted output of each of the light receiving elements, and an adding section that adds the weighted outputs of the light receiving elements opposed to a respective one of the compartments.08-02-2012
20090048125Biochip microsystem for bioinformatics recognition and analysis - A system with applications in pattern recognition, or classification, of DNA assay samples. Because DNA reference and sample material in wells of an assay may be caused to fluoresce depending upon dye added to the material, the resulting light may be imaged onto an embodiment comprising an array of photodetectors and an adaptive neural network, with applications to DNA analysis. Other embodiments are described and claimed.02-19-2009
20090042745BIOSENSOR CHIP - A biosensor chip is constituted by: a substrate; a metal film which is physically attached to the substrate; and a self assembled monolayer constituted by alkyl chains, which is physically attached to the metal film. Ligands and at least one functional group, selected from a group consisting of a hydroxyl group, a carboxyl group, an alkoxy group, a methyl group, and hydrogen atoms are physically attached to the self assembled monolayer. The ratio between the total number of alkyl chains physically attached to the metal film and the number of alkyl chains which are covalently bonded with the ligands is within a range of 0.40 to 0.99.02-12-2009
20090042744MICRODEVICES FOR SCREENING BIOMOLECULES - Methods and devices for the parallel, in vitro screening of biomolecular activity using miniaturized microfabricated devices are provided. The biomolecules immobilized on the surface of the devices of the present invention include proteins, polypeptides, polynucleotides, polysaccharides, phospholipids, and related unnatural polymers of biological relevance. These devices are useful drug development, functional proteomics and clinical diagnostics and are preferably used for the parallel screening of families of related proteins.02-12-2009
20090247427LABEL-FREE HIGH THROUGHPUT BIOMOLECULAR SCREENING SYSTEM AND METHOD - A screening system and method are described herein which provide a unique and practical solution for enabling label-free high throughput screening (HTS) to aid in the discovery of new drugs. In one embodiment, the screening system enables direct binding assays to be performed in which a biomolecular interaction of a chemical compound (drug candidate) with a biomolecule (therapeutic target) can be detected using assay volumes and concentrations that are compatible with the current practices of HTS in the pharmaceutical industry. The screening system also enables the detection of bio-chemical interactions that occur in the wells of a microplate which incorporates biosensors and surface chemistry to immobilize the therapeutic target at the surface of the biosensors. The screening system also includes fluid handling and plate handling devices to help perform automated HTS assays.10-01-2009
20130137607POINT OF CARE IMMUNIZATION TESTING SYSTEM - A point of care immunization system based upon microfluidics and micro-titration technologies to rapidly test a patient in order to ascertain an immunization profile so that vaccinations can be administered to address identified gaps. A point of care system comprised of uniquely shaped and color distinguishing sample and test cartridges, with said test cartridges configured to meet healthcare requirements of national governing bodies. A point of care system including an easy access vaccine storage device with indicators to provide data on viability of stored vaccines.05-30-2013
20110118151MULTIPLE DISPLACEMENT AMPLIFICATION - The present invention provides methods kits and systems for performing multiple displacement amplification reactions. In one method a sample of nucleic acid is provided. The nucleic acid is contacted with a reaction mixture which includes a set of oligonucleotide primers, a one or more polymerase enzymes and a detergent. The reaction mixture is then subjected to conditions under which the nucleic acid sequence is amplified to produce an amplified product in a multiple displacement reaction. The method may also be carried out by contacting the nucleic acid with the reaction mixture in the form of an emulsion. A kit is also provided for carrying out either the methods described above. The kit includes one or more polymerases, a plurality of primers and a detergent. The kit may also include a hydrophobic polymer and may include instructions for performing a multiple displacement amplification reaction on a nucleic acid sample.05-19-2011
20090069199METHOD AND DEVICE FOR OPTICAL DETECTION OF SUBSTANCES IN A LIQUID OR GASEOUS MEDIUM - The invention relates to a device for optical detection of substances in a liquid or gaseous medium, with a substrate with molecules for detecting the substances that are to be detected, wherein these molecules are immobilised at a surface of the substrate or in the substrate and wherein the substances that are to be detected can essentially be selectively bound to these molecules, wherein light waves can be coupled into the substrate and can be guided through this, and wherein the substrate is a foil element made of a transparent material in which a coupling structure for coupling the light waves is integrally formed and in which the coupled light waves can be guided.03-12-2009
20120035084DEVICE AND METHOD FOR PARTICLE COMPLEX HANDLING - An embodiment of the invention relates to a device for detecting an analyte in a sample. The device comprises a fluidic network and an integrated circuitry component. The fluidic network comprises a sample zone, a cleaning zone and a detection zone. The fluidic network contains a magnetic particle and/or a signal particle. A sample containing an analyte is introduced, and the analyte interacts with the magnetic particle and/or the signal particle through affinity agents. A microcoil array or a mechanically movable permanent magnet is functionally coupled to the fluidic network, which are activatable to generate a magnetic field within a portion of the fluidic network, and move the magnetic particle from the sample zone to the detection zone. A detection element is present which detects optical or electrical signals from the signal particle, thus indicating the presence of the analyte.02-09-2012
20110130311METHOD AND SYSTEM FOR DIAGNOSING VIRUS - Disclose herein is a method for diagnosing virus, comprising the steps of: (a) collecting a sample and lysing virus present in the sample; (b) treating the lysed sample with a specific protease to digest a protein in the sample into peptides; (c) measuring the masses of the peptides in the sample with a mass measurement device; and (d) comparing the masses of the peptides in the sample to the masses of peptides derived from known viral proteins digested with the same protease as used in step (b), thus identifying the protein from which the peptides of the sample were derived. Also disclosed is a system for diagnosing virus which can be used to carry out the above diagnostic method.06-02-2011
20110130310MICROBIOREACTOR AND MICROTITER PLATE COMPRISING A PLURALITY OF MICROBIOREACTORS - The present invention relates to a microbioreactor comprising a sample support (06-02-2011
20090312200Nucleic Acid Analysis Chip Integrating a Waveguide and Optical Apparatus for the Inspection of Nucleic Acid Probes - A chip for nucleic acid analysis includes a body (12-17-2009
20110152127Light Transmitted Assay Beads - A micro bead having a digitally coded structure that is partially transmissive and opaque to light. The pattern of transmitted light is determined by to decode the bead. The coded bead may be structured a series of alternating light transmissive and opaque sections, with relative positions, widths and spacing resembling a 1D or 2D bar code image. To decode the image, the alternating transmissive and opaque sections of the body are scanned in analogous fashion to bar code scanning. The coded bead may be coated or immobilized with a capture or probe to effect a desired bioassay. The coded bead may include a paramagnetic material. A bioanalysis system conducts high throughput bioanalysis using the coded bead, including a reaction detection zone and a decoding zone.06-23-2011
20100069265SYSTEM AND METHOD FOR PROCESSING LARGE NUMBER OF BIOLOGICAL MICROARRAYS - A system and method for processing biological sensors. The system includes a support component configured to support a fluidic component. The fluidic component includes at least a first container and a second container. The first container is capable of holding a first volume of a first fluid, and the second container is capable of holding a second volume of a second fluid. Additionally, the system includes a hybridization component configured to perform a hybridization process on a first sensor and a second sensor. Moreover, the system includes a transport component configured to move the first sensor, directly or indirectly, from the hybridization component into the first container and in contact with the first volume of the first fluid.03-18-2010
20110251110Methods for Sequencing Individual Nucleic Acids Under Tension - The invention provides apparatuses and methods of use thereof for sequencing nucleic acids subjected to a force, and thus considered under tension. The methods may employ but are not dependent upon incorporation of extrinsically detectably labeled nucleotides.10-13-2011
20110059870Assay Plates, Reader Systems and Methods for Luminescence Test Measurements - Luminescence test measurements are conducted using an assay module having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.03-10-2011
20110071055INTEGRATED CARTRIDGE - An integrated cartridge for sample processing and analysis is disclosed. The integrated cartridge contains a sample preparation chamber having a sample inlet and a sample outlet, and a sample purification chamber adapted to receive a replaceable sample purification unit containing a housing and an extraction filter inside the housing. The extraction filter specifically binds to a molecule of interest. The sample purification chamber has a sample inlet that is in fluid communication with the sample outlet of the sample preparation chamber. Also disclosed is a microarray-based sample analysis (MBSA) system.03-24-2011
20110009296NUCLEIC ACID SEQUENCING SYSTEM AND METHOD - A technique for sequencing nucleic acids in an automated or semi-automated manner is disclosed. Sample arrays of a multitude of nucleic acid sites are processed in multiple cycles to add nucleotides to the material to be sequenced, detect the nucleotides added to sites, and to de-block the added nucleotides of blocking agents and tags used to identify the last added nucleotide. Multiple parameters of the system are monitored to enable diagnosis and correction of problems as they occur during sequencing of the samples. Quality control routines are run during sequencing to determine quality of samples, and quality of the data collected.01-13-2011
20100144558SYSTEMS AND METHODS FOR BIODOSIMETRY WITH BIOCHIP USING GENE EXPRESSION SIGNATURES - Exposure to ionizing radiation can produce a well-defined dose dependent signature in terms of changes in gene expression. In approaches and devices described herein, such a signature can be used to generate and use a self-contained radiation biodosimeter device, based on, for example, a blood finger stick. Various aspects of the invention are directed to biodosimetry with a fully integrated biochip using gene expression signatures.06-10-2010
20080242562APPARATUS AND METHODS FOR DETECTING NUCLEIC ACID IN BIOLOGICAL SAMPLES - There are disclosed apparatus and methods for the field-assisted acceleration of biological processes involving charged entities, including in particular the detection of target DNA in a biological sample. A reaction cell is provided with a dielectric surface, and a field is generated by inducing charge-separation in the dielectric material by applying a potential to an electrode in contact with the dielectric material.10-02-2008
20080255008GELATION CONTROLLED FLUID FLOW IN A MICROSCALE DEVICE - A method of self regulating a process of manufacturing a biological device which includes the steps of: choosing a first material and a second material based on a correlation of a parameter of the second material with a parameter of the first material; and merging the first material with the second material where the correlation of the parameter of the second material with the parameter of the first material self regulates the merging step to provide a distinct patterning of the first material and the second material.10-16-2008
20100323925Nanosensor array for electronic olfaction - A detector system is described including arrays having a plurality of nanoelectronic sensors comprising a channel including a nanostructured element disposed on a substrate, the nanostructured element functionalized by one or more materials disposed on or adjacent to the nanostructured element so as to operatively influence one or more sensor electrical properties. In certain embodiments, the nanostructured element comprise one or more nanotubes, and the functionalization material may include nanoparticles composed of one or more metals, metal oxides, salts, or other inorganic or organic materials or composites of these.12-23-2010
20080255007Substrate Material For Handling and Analyzing Samples - The invention relates to a substrate material for analyzing one or more fluid samples for the presence, amount or identity of one or more analytes in the samples, whereby the substrate material is adapted in that way that a flow of the sample or parts thereof in and/or with the substrate material is influenced and/or caused by phase transitions, preferably photoinducable phase transitions, in selected areas of the substrate material.10-16-2008
20110009297Consumable elements for use with fluid processing and detection systems - One embodiment describes an automated and flexible system to analyze probe arrays. It comprises a plurality of arrays mounted on pegs that are moved by an instrument handling robot to liquid reaction stations.01-13-2011
20110021383APPARATUSES FOR REAL-TIME, SINGLE MOLECULE SEQUENCE DETERMINATION - A sequencing methodology is disclosed that allows a single DNA or RNA molecule or portion thereof to be sequenced directly and in substantially real time. The methodology involves engineering a polymerase and/or dNTPs with atomic and/or molecular tags that have a detectable property that is monitored by a detection system.01-27-2011
20110136699MANUFACTURING AND PROCESSING POLYMER ARRAYS - The invention provides methods to process multiple microarrays by providing a microarray plate and processing plates. In an embodiment of the invention, methods for assembling microarray plates by using wafers are described for high throughput microarray processing.06-09-2011
20100167960METHODS AND APPARATUS FOR SCREENING AND DETECTING MULTIPLE GENETIC MUTATIONS - An assay system and methods are described where patient samples containing genomic DNA are analyzed for the presence of known genetic polymorphisms using a universal reporter strategy. In a preferred embodiment, the amplified DNA is localized at test sites in an array of sites on a microchip followed by a series of hybridization reactions that screen for the presence of a single mutation from among a number of mutations, and allow the identification of specific mutations. In addition to universal reporters, the assay may use blockers and discriminators for screening and identification of known polymorphisms.07-01-2010
20120028848Binding method and apparatus for sorting objects - The present invention relates to a method and apparatus of sorting objects including, providing a sample having wanted objects and unwanted objects; coating a surface of a sample holder with an antibody; placing an eluted sample on the sample holder; binding an antigen in the wanted objects with the antibody on the surface of the sample holder to sort the objects into wanted objects and unwanted objects; separating the wanted objects; and performing PCR-based STR analysis on the wanted objects. In one embodiment, holographic optical trapping is used to further sort the wanted objects. In other embodiments, the wanted objects are sperm and the antibody is a human sperm specific antibody, and the PCR is single cell PCR-based STR analysis. In still other embodiments, the binding is direct or indirect, ligands are used to bind to object-specific organomolecules, and protein A or protein G are used to bind the antibody.02-02-2012
20110263463INTEGRATED SENSOR ARRAYS FOR BIOLOGICAL AND CHEMICAL ANALYSIS - The invention is directed to apparatus and chips comprising a large scale chemical field effect transistor arrays that include an array of sample-retaining regions capable of retaining a chemical or biological sample from a sample fluid for analysis. In one aspect such transistor arrays have a pitch of 10 μm or less and each sample-retaining region is positioned on at least one chemical field effect transistor which is configured to generate at least one output signal related to a characteristic of a chemical or biological sample in such sample-retaining region. In one embodiment, the characteristic of said chemical or biological sample is a concentration of a charged species and wherein each of said chemical field effect transistors is an ion-sensitive field effect transistor having a floating gate with a dielectric layer on a surface thereof, the dielectric layer contacting said sample fluid and being capable of accumulating charge in proportion to a concentration of the charged species in said sample fluid. In one embodiment such charged species is a hydrogen ion such that the sensors measure changes in pH of the sample fluid in or adjacent to the sample-retaining region thereof. Apparatus and chips of the invention may be adapted for large scale pH-based DNA sequencing and other bioscience and biomedical applications.10-27-2011
20110190170COMPOSITIONS FOR USE IN IDENTIFICATION OF ANTIBIOTIC-RESISTANT BACTERIA - The present invention relates generally to identification of antibiotic-resistant bacteria and provides methods, compositions and kits useful for this purpose when combined, for example, with molecular mass or base composition analysis.08-04-2011
20110306522MICROFLUIDIC PROTEIN CRYSTALLOGRAPHY - The use of microfluidic structures enables high throughput screening of protein crystallization. In one embodiment, an integrated combinatoric mixing chip allows for precise metering of reagents to rapidly create a large number of potential crystallization conditions, with possible crystal formations observed on chip. In an alternative embodiment, the microfluidic structures may be utilized to explore phase space conditions of a particular protein crystallizing agent combination, thereby identifying promising conditions and allowing for subsequent focused attempts to obtain crystal growth.12-15-2011
20110111987CENTRIFUGAL MICROFLUIDIC SYSTEM FOR NUCLEIC ACID SAMPLE PREPARATION, AMPLIFICATION, AND DETECTION - A microfluidic system for processing a sample includes a microfluidic CD in the form a rotatable disc, the disc containing a plurality of separate lysis chambers therein. A magnetic lysis blade and lysis beads are disposed in each of the lysis chambers and a plurality of stationary magnets are disposed adjacent to and separate from the microfluidic CD. The stationary magnets are configured to magnetically interact with each of the magnetic lysis blades upon rotation of the microfluidic CD. Each lysis chamber may have its own separate sample inlet port or, alternatively, the lysis chambers may be connected to one another with a single inlet port coupled to one of the lysis chambers. Downstream processing may include nucleic acid amplification using thermoelectric heating as well as detection using a nucleic acid microarray.05-12-2011
20110312753LOC WITH INTEGRAL LED DRIVER FOR EXCITATION LED - A microfluidic device having a supporting substrate, a probe with a nucleic acid sequence for hybridization with a target nucleic acid sequence to form a probe-target hybrid and generate a fluorescence signal in response to an excitation light, and, CMOS circuitry on the supporting substrate for operative control of the excitation light.12-22-2011
20110312797PORTABLE TEST MODULE FOR FLUORESCENCE EXCITATION OF PROBE NUCLEIC ACID SEQUENCES - A test module for detecting hybridization of probes with target nucleic acid sequences, the test module having a casing configured for hand held portability, the casing having a receptacle for receiving a biological sample with target nucleic acid sequences, an array of probes for hybridization with the target nucleic acid sequences, an excitation light source for illuminating the array of probes, and a photosensor for sensing a fluorescence emission from any of the probes in the array that have hybridized with the target nucleic acid sequences.12-22-2011
20110312759GENETIC ANALYSIS LOC WITH REAGENT RESERVOIR - A LOC device for performing a genetic diagnostic assay, the LOC device having a supporting substrate, a microsystems technology (MST) layer supported on the substrate, the MST layer having an inlet for receiving a biological sample containing target nucleic acid sequences, probes for hybridization with the target nucleic acid sequences to form probe-target hybrids, a flow-path extending from the inlet to the probes, and, a reagent reservoir containing a reagent for addition to the sample in the flow-path upstream of the probes.12-22-2011
20110312756MICROFLUIDIC DEVICE WITH LOW REAGENT VOLUMES - A microfluidic device for biochemical processing and analysis, the microfluidic device having a supporting substrate, a microsystems technology (MST) layer supported on the substrate, the MST layer having an inlet for receiving biochemical liquid, and, a reagent reservoir containing a reagent necessary for the biochemical processing, wherein, the reagent reservoir contains less than 1,000,000,000 cubic microns of reagent.12-22-2011
20110312754MICROFLUIDIC DEVICE FOR DETECTION OF MITOCHONDRIAL DNA VIA ELECTROCHEMILUMINESCENCE MODULATED HYBRIDIZATION - A microfluidic device for analysis of mitochondrial DNA in a sample, the microfluidic device having an inlet for receiving a sample of biological material having cells with mitochondria containing mitochondrial DNA, a lysis section for lysing the mitochondria to release the mitochondrial DNA, electrochemiluminescent (ECL) resonance energy transfer probes for hybridization with target nucleic acid sequences in the mitochondrial DNA to form probe-target hybrids, and, a photosensor for detecting the probe-target hybrids.12-22-2011
20120046203IMAGING ANALYZER FOR TESTING ANALYTES - The invention provides analyzers that improve tests for detecting specific cellular, viral, and molecular targets in clinical, industrial, or environmental samples. The invention permits efficient and specific selection and sensitive imaging detection of individual microscopic targets at low magnification. Automated embodiments allow efficient walk-away, on-demand, random-access high-throughput testing. The analyzers perform tests without requiring wash steps thus streamlining engineering and lowering costs. Thus, the invention provides analyzers that can deliver rapid, accurate, and quantitative, easy-to-use, and cost-effective tests for analytes.02-23-2012
20120004144MICROELECTROPORATION DEVICE FOR GENOMIC SCREENING - We have developed an microelectroporation device that combines microarrays of oligonucleotides, microfluidic channels, and electroporation for cell transfection and high-throughput screening applications (e.g. RNA interference screens). Microarrays allow the deposition of thousands of different oligonucleotides in microscopic spots. Microfluidic channels and microwells enable efficient loading of cells into the device and prevent cross-contamination between different oligonucleotides spots. Electroporation allows optimal transfection of nucleic acids into cells (especially hard-to-transfect cells such as primary cells) by minimizing cell death while maximizing transfection efficiency. This invention has the advantage of a higher throughput and lower cost, while preventing cross-contamination compared to conventional screening technologies. Moreover, this device does not require bulky robotic liquid handling equipment and is inherently safer given that it is a closed system.01-05-2012
20120252704BIOANALYTICAL INSTRUMENTATION USING A LIGHT SOURCE SUBSYSTEM - The invention relates to a light source for irradiating molecules present in a detection volume with one or more selected wavelengths of light and directing the fluorescence, absorbance, transmittance, scattering onto one or more detectors. Molecular interactions with the light allow for the identification and quantitation of participating chemical moieties in reactions utilizing physical or chemical tags, most typically fluorescent and chromophore labels. The invention can also use the light source to separately and simultaneously irradiate a plurality of capillaries or other flow confining structures with one or more selected wavelengths of light and separately and simultaneously detect fluorescence produced within the capillaries or other flow confining structures. In various embodiments, the flow confining structures can allow separation or transportation of molecules and include capillary, micro bore and milli bore flow systems. The capillaries are used to separate molecules that are chemically tagged with appropriate fluorescent or chromophore groups.10-04-2012
20110166045WAFER SCALE PLASMONICS-ACTIVE METALLIC NANOSTRUCTURES AND METHODS OF FABRICATING SAME - Plasmonics-active nanostructure substrates—developed on a wafer scale in a reliable and reproducible manner such that these plasmonics-active nanostructures have nano-scale gaps (that include but are not limited to sub-10 nm gaps or sub-5 nm gaps) that provide the highest EM field enhancement between neighboring plasmonics-active metallic or metal-coated nanostructures. The plasmonics-active nanostructure substrates relate to environmental sensing based on SERS, SPR, LSPR, and plasmon enhanced fluorescence based sensing as well as for developing plasmonics enhanced devices such as solar cells, photodetectors, and light sources. Controllable development of sub-2 nm gaps between plasmonics-active nanostructures can also be achieved. Also, the size of the nano-scale gap regions can be tuned actively (e.g., by the application of voltage or current) to develop tunable sub-5 nm gaps between plasmonic nanostructures in a controllable manner.07-07-2011
20120015851METHOD AND DEVICE FOR RAPID, DETECTION OF SPECIFIC REACTIONS USING NON-MAGNETIC AND MAGNETIC NANOPARTICLES - A method and apparatus for conducting specific binding assays with two or more particles is claimed. A non-magnetic nanoparticle capable of binding the target of interest is mixed with a magnetic particle capable of binding a species directed toward binding the same target of interest. Following the application of the mixture to a capillary tube or other container that allows the separation with a magnetic field or other force, the resultant movement of the magnetic or combination of magnetic and non-magnetic assemblies can be read visually or with the aid of an appropriate instrument.01-19-2012
20120157350Brownian Microbarcodes for Bioassays - Presented are encoded microparticles, methods of use in biological assays, and flexible, modular instrument systems for conducting a variety of biological assays using the encoded microparticles. The systems include various instrumentation components which are exchangeable and offer a single flexible platform on which a large number of different types of experiments and assays may be conducted including, for example, microarray analysis, encoded microparticle single and multiplex detection, tissue dissection and isolation, and other genetic analysis techniques.06-21-2012
20120172260System and methods for localizing and analyzing samples on a Bio-Sensor chip - Chips that include one or more particle manipulation mechanisms, or force transduction elements, provided at specific locations to manipulate and localize particles proximal the substrate surface. In one embodiment, individually addressable magnetic control mechanisms such as electric coils are provided at specific locations to create a magnetic field to attract magnetic particles, such a magnetic or magnetizable beads, to those specific locations. In another embodiment, electrostatic control mechanisms such as electrodes are provided to attract and manipulate electrically charged micro-particles. A location may include a crater or well formed in the substrate, or it may include an element on the surface of the substrate. In some embodiments, one or more sensors are located proximal specific locations, e.g., specific craters, so as to analyze specific conditions at each location. In other embodiments, multiple locations share one or more sensors.07-05-2012
20120108470MICROFLUIDIC MAGNETOPHORETIC DEVICE AND METHODS FOR USING THE SAME - A microfluidic device may employ one or more sorting stations for separating target species from other species in a sample. The separation is driven by magnetophoresis. A sorting station generally includes separate buffer and sample streams. A magnetic field gradient applied to the sorting station deflects the flow path of magnetic particles (which selectively label the target species) from a sample stream into a buffer stream. The buffer stream leaving the sorting station is used to detect or further process purified target species labeled with the magnetic particles.05-03-2012
20120157349CELL CHIP PACKAGE - There is provided a cell chip package, including: a chamber having an opening formed in a region thereof; a cell chip received in an inside of the chamber and having a biomaterial array formed therein; and a sealing membrane mounted in the opening and made of a gas permeable material. The cell chip package may facilitate experimentation and long-term storage with respect to a cell chip.06-21-2012
20120071363METHODS AND APPARATUS FOR MEASURING ANALYTES USING LARGE SCALE FET ARRAYS - Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in hydrogen ion concentration (pH), changes in other analyte concentration, and/or binding events associated with chemical processes relating to DNA synthesis.03-22-2012
20120071365Detection Device Having Increased Detection Rate, and Method for Quick Detection of Biological Molecules - A biological molecule detection device that includes a detection array, arranged on a body and having one or more probes for detecting corresponding electrically charged molecules, wherein a time varying electric field generating circuit is provided for generating at least one time varying electric field around the detection array within the detection region. The time varying electric field moves the electrical charged molecules repeatedly back and forth over the probes, thus providing increased opportunities for interaction and speeding the detection process.03-22-2012
20120129732Methods and Apparatus for Measuring Analytes Using Large Scale FET Arrays - Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in hydrogen ion concentration (pH), changes in other analyte concentration, and/or binding events associated with chemical processes relating to DNA synthesis.05-24-2012
20100267590Reaction Surface Array Diagnostic Apparatus - A reaction surface array diagnostic apparatus and method of making the same includes a substrate carrying a plurality of reaction surfaces, a plate and a gasket, each having a plurality of through bores, alignable with one of the reaction surfaces and forming a fluid tight well about each reaction surface when the gasket and the plate are sealingly affixed to the substrate to form a stack. Clamp members engage opposite side edges of a stack to compress the gasket. A plurality of side-by-side disposed clamped stacks of plates, gaskets and substrates are mounted in a tray in the standard footprint of a microtitre plate. Alternately, the plate and the gasket are combined into a single plate formed of a flexible material having an adhesive on one surface.10-21-2010
20100292105Methods and devices for concentration and fractionation of analytes for chemical analysis - A multi-well cassette configuration and an instrument capable of accepting the cassette and thereafter pre-concentrating and purifying analytes from biological samples held in the cassette wells, such as human serum, for subsequent analysis by Matrix-Assisted Laser Desorption Ionization Mass Spectrometry (MALDI MS).11-18-2010
20120190591Assay Plates, Reader Systems and Methods for Luminescence Test Measurements - Luminescence test measurements are conducted using an assay module having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.07-26-2012
20120190590Assay Plates, Reader Systems and Methods for Luminescence Test Measurements - Luminescence test measurements are conducted using an assay module having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.07-26-2012
20120190589Assay Cartridges and Methods of Using the Same - Assay cartridges are described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain embodiments, these cartridges are adapted to receive and analyze a sample collected on an applicator stick. Also described are kits including such cartridges and a cartridge reader configured to analyze an assay conducted using an assay cartridge.07-26-2012
20120190588Methods for Identifying Agents that Inhibit Cell Migration, Promote Cell Adhesion and Prevent Metastasis - Disclosed are methods for identification of agents that modulate cell attachment, cell migration and cell viability. Cancer and primary cells adhered to a matrix are treated with agent(s) that modulate ActRII signaling and cell adhesion. Agents are tested that modulate cell adhesion, detachment, invasion and viability. Agents that modulate the expression, phosphorylation, function and translocation of ActRII signaling pathway members also can predict agents that modulate cell adhesion, detachment, invasion and viability. The methods have utility in identifying agents that prevent cancer cell metastasis, wound dehiscence, aortic dissection and aid retina attachment and skin replacement and fertility.07-26-2012
20120264654DIAGNOSTIC ELEMENT, AND A DIAGNOSTIC DEVICE COMPRISING A DIAGNOSTIC ELEMENT - The invention relates to a diagnostic element. The diagnostic element comprises an inlet passage, a holding port and an outlet passage. The holding port is capable of encapsulating a diagnostic gel. The invention also relates to a diagnostic device that comprises at least one inlet port, a preparation port, a diagnostic element that comprises an inlet passage, a holding port, an outlet passage and an outlet port.10-18-2012
20110003718SELF-SENSING ARRAY OF MICROCANTILEVERS CHEMICAL DETECTION - The invention provides a chemical detection system for detecting at least one target chemical species, including a self-sensed cantilevered probe array having a plurality of self-sensed cantilevered probes, at least one chemical-sensitive coating material applied to at least one cantilevered probe in the cantilevered probe array, and an interface circuit that is coupled to the cantilevered probe array. At least one cantilevered probe in the cantilevered probe array exhibits a shifted cantilevered probe response when the cantilevered probe array is exposed to the target chemical species and the interface circuit actuates the cantilevered probe. A handheld chemical detection system and a method of operation are also disclosed.01-06-2011
20110046022CRYSTALLIZATION DEVICE FOR HIGH-THROUGHPUT VISUAL INSPECTION AND X-RAY DIFFRACTION ANALYSIS - A crystallization chip has a two-dimensional substrate surface with modified wetting properties convenient for the evaluation of the crystallization experiment results by optical microscope and by X-ray diffraction. A crystallization chip mount comprises a base and a support structure that is connected to the base. The support structure provides a first channel that receives a portion of the crystallization chip. A crystallization chip holder comprises a body defining at least one slot to slidably receive the crystallization chip described herein. The at least one slot extends from an upper surface to a lower surface of the body. The crystallization chip holder further includes at least one support surface for each slot. For a given slot the at least one support surface is disposed on an edge of at least two surfaces of portions of the body that define the given slot. During use, the at least one support surface supports the crystallization chip prior to, during or after the formation of crystals.02-24-2011
20110237464Guided Mode Resonant Filter Biosensor Using a Linear Grating Surface Structure - Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also provides optical devices useful as narrow band filters.09-29-2011
20120088696MICRO ELECTROCHEMICAL MULTIPLEX REAL-TIME PCR PLATFORM - A micro electrochemical multiplex Real-Time PCR platform which can be widely used to rapidly amplify, examine, and quantify target nucleotides in real-time, and can be used in sepsis diagnosis, rapid detection of animal/plant viral or bacterial infections, plant disease control, real-time environmental monitoring, food industry contamination prevention, and improvement of agricultural varieties.04-12-2012
20100167959MICROELECTRONIC DEVICE WITH HEATING ARRAY - The invention relates to different designs of a microelectronic device comprising an array of heating elements (HE) with local driving units (CU07-01-2010
20100022416ASSAY PLATES, METHODS AND SYSTEMS HAVING ONE OR MORE ETCHED FEATURES - The present invention includes composition, methods of making and methods of using a multi-nano-well plate having a first layer at least partially disposed on the substrate and one or more nano-wells that extends through the first layer that extends toward the substrate, wherein the one or more nano-wells having an opening in the first layer connected to bottom layer by one or more walls.01-28-2010
20120149603SAMPLE ANALYSIS SYSTEM - An integrated sample analysis system is disclosed. The sample analysis system contains (1) a sample preparation/analysis module having sample purification device comprising a monolith that binds specifically to nucleic acids and a sample analysis device comprising a microarray enclosed in a reaction chamber having a hydrophilic interior surface; (2) a temperature control module comprising a thermocycler having a thermally conductive temperature-control bladder; and (3) an imaging device capable of capturing an image of the microarray in the reaction chamber.06-14-2012
20130017979SENSOR SUBSTRATE AND ARRAY SUBSTRATE USING THE SAME - A sensor substrate includes a base and fibrous projections on an upper surface of the base. The fibrous projections have fixed ends fixed to the upper surface of the base and free ends opposite to the fixed ends, respectively. The fibrous projections provide a fixed end-side region including the fixed ends and a free end-side region including the free ends. The total surface area at which the fibrous projections in the fixed end-side region is larger than that in the free end-side region.01-17-2013
20080255006MAGNETIC NANOPARTICLES, MAGNETIC DETECTOR ARRAYS, AND METHODS FOR THIER USE IN DETECTING BIOLOGICAL MOLECULES - Magnetic nanoparticles and methods for their use in detecting biological molecules are disclosed. The magnetic nanoparticles can be attached to nucleic acid molecules, which are then captured by a complementary sequence attached to a detector, such as a spin valve detector or a magnetic tunnel junction detector. The detection of the bound magnetic nanoparticle can be achieved with high specificity and sensitivity.10-16-2008
20080227663SYSTEMS AND METHODS FOR HIGH SPEED ARRAY PRINTING AND HYBRIDIZATION - Novel and improved systems and methods for high speed arraying, hybridization, quantitative development and/or assaying are provided. Some embodiments provide a web based arraying format. Some other embodiments provide a sheet based arraying format. Some embodiments use a drop on drop assaying or hybridization mode. In some embodiments, a substantially inert substrate is utilized. In some other embodiments, an interactive substrate is utilized.09-18-2008
20080227664CELL ARRAY STRUCTURAL BODY AND CELL ARRAY - The present invention provides a cell array structural body containing a substrate, a plurality of micropores piercing the substrate from one surface to another surface, through which a sample cell can pass, and a capture/release unit for the sample cell on a wall surface of each micropore, as well as a cell array with such structural body detachably immobilizing sample cells in its micropores. In using the cell array structural body and the cell array for drug evaluations or the like, handling of a culture medium or a drug solution, or washing procedure is easy, and harvest of a desired cell from the cell array is easy and trustworthy.09-18-2008
20080227662Livestock tissue identification system - A system receives tissue samples and identification information of sources of tissue samples in an array of at least two and preferably at least four containers having one open end. A support secures the array of containers together. The open end of each container faces in a same direction. The array contains unique identification information for each of the at least two or at least four containers. The unique identification information is machine readable. At least two or at least four open end caps securely close the open end.09-18-2008
20130096035SELF-SUSTAINED FLUIDIC DROPLET CASSETTE AND SYSTEM FOR BIOCHEMICAL ASSAYS - A fluidic cartridge for biochemical assays includes a cartridge body defining a first droplet region and a second droplet region with a droplet restraining barrier therebetween. The droplet restraining barrier has a gap between the first and the second droplet regions. The fluidic cartridge also includes a first droplet dispensed in the first droplet region. The first droplet includes a plurality of magnetic particles dispersed therein. The fluidic cartridge also includes a second droplet disposed in the second droplet region. The plurality of magnetic particles are sufficiently small to be drawn through the gap between the first and second droplet regions when compelled by an applied magnetic field, and the first droplet is restrained by the restraining barrier while the plurality of magnetic particles are drawn through the gap. A biochemical assay system includes a stage adapted to receive a fluidic cartridge, and a magnetic control assembly that includes a magnet. The magnet of the magnetic control assembly is movable to direct motion of magnetic particles contained within the fluidic cartridge.04-18-2013
20130143775METHOD FOR DETECTING BIOMOLECULES ELECTRICALLY AND BIOCHIP THEREFOR - The present invention relates to a method for detecting the presence and/or the reaction of a biomolecule by monitoring changes of electrical property accurately according to the biological, biochemical or chemical reaction of the biomolecule, and a biochip provided for this purpose.06-06-2013
20130184187SYSTEMS AND METHODS FOR BIOMARKER ANALYSIS - Systems and methods of biomarker analysis. In at least one embodiment of a system for determining the therapeutic potential of a therapeutic compound the present disclosure, the system comprises a detection platform, a computer database capable of receiving a plurality of binding characteristics, a processor operably coupled to the computer database and the detection platform. In at least one embodiment, the processor has and executes a software program operational to determine a binding characteristic of the detection agent and a stabilized diagnostic agent in each of the plurality of detection sites, compare the binding characteristic among each of the plurality of detection sites, wherein the comparison of binding characteristics is capable of determining the stabilizing agent with the greatest effect on the binding characteristic between the detection agent and the diagnostic agent, generate a binding record using the compared binding characteristics, and deliver the binding record to a recipient.07-18-2013
20110230375METHODS AND APPARATUS FOR MEASURING ANALYTES USING LARGE SCALE FET ARRAYS - Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in hydrogen ion concentration (pH), changes in other analyte concentration, and/or binding events associated with chemical processes relating to DNA synthesis.09-22-2011
20110312737SINGLE-USE TEST MODULE FOR ELECTROCHEMILUMINESCENT DETECTION OF TARGETS - A test module for detecting target nucleic acid sequences in a fluid, the test module having an outer casing with an inlet for receiving a fluid containing the target nucleic acid sequences, an array of electrochemiluminescent (ECL) probes for hybridization with the target nucleic acid sequences to form probe-target hybrids, and, electrodes positioned for receiving an electrical pulse, the probe-target hybrids being configured to emit a photon of light when excited by current between the electrodes, and, a photosensor for detecting the light emitted by the probes, wherein during use, addition of the fluid to the probes prevents subsequent addition of other fluid to the probes.12-22-2011
20110312736MICROFLUIDIC DEVICE WITH FLOW RATE SENSOR - A microfluidic device for processing a fluid, the microfluidic device having an inlet for receiving the fluid, functional sections for processing the fluid, a flow-path extending from the inlet into at least one of the functional sections, a flow rate sensor with a conductive element positioned in proximity of the fluid flowing along the flow-path, CMOS circuitry configured for measuring the temperature of the conductive element, wherein, the CMOS circuitry is configured to provide a predetermined current through the conductive element and measure the electrical resistance of the conductive element such that a flow speed is derived from the current, the temperature sensor output and the electrical resistance, and a flow rate is derived using the flow speed and the flow-path cross section transverse to the flow direction at the conductive element.12-22-2011
20110312735MICROFLUIDIC DEVICE WITH NUCLEIC ACID AMPLIFICATION SECTION - A microfluidic device for amplifying nucleic acid sequences, the microfluidic device having an inlet for receiving a sample containing genetic material, a plurality of reagent reservoirs containing reagents for addition to the sample, and, a nucleic acid amplification section for amplifying nucleic acid sequences in the genetic material.12-22-2011
20110312734TEST MODULE WITH SUSPENDED ELECTROCHEMILUMINESCENT PROBES - A test module for detecting target nucleic acid sequences in a fluid, the test module having an outer casing having an inlet for receiving the fluid containing the target nucleic acid sequences, electrode pairs for receiving an electrical pulse, electrochemiluminescent (ECL) probes adjacent each of the electrode pairs respectively, each of the ECL probes having an ECL luminophore for emitting photons when in an excited state and a functional moiety for quenching photon emission from the ECL luminophore by resonant energy transfer, such that the electrical pulse to the electrode pair excites the ECL luminophores, wherein, the ECL probes are not anchored to a surface and form a suspension in the fluid containing the target nucleic acid sequences during detection.12-22-2011
20110312733LOC DEVICE WITH NUCLEIC ACID AMPLIFICATION SECTION - A lab-on-a-chip (LOC) device for amplifying nucleic acid sequences, the LOC device having an inlet for receiving a sample containing genetic material, a supporting substrate, a plurality of reagent reservoirs, and, a nucleic acid amplification section for amplifying nucleic acid sequences in the genetic material, wherein, the nucleic acid amplification section is supported on the supporting substrate.12-22-2011
20110312732TEST MODULE USING LANTHANIDE METAL-LIGAND COMPLEX, ELECTROCHEMILUMINESCENT LUMINOPHORES - A test module for excitation of electrochemiluminescent probes configured to detect target nucleic acid sequences, the test module having an outer casing with an inlet for receiving a fluid containing the target nucleic acid sequences, electrochemiluminescent (ECL) probes having an ECL luminophore for emitting photons when in an excited state and a functional moiety for quenching photon emission from the ECL luminophore by resonant energy transfer, and, electrodes for receiving an electrical pulse to excite the ECL luminophores, such that the ECL probes that have detected one of the target nucleic acid sequences reconfigure such that the functional moiety does not quench the photon emission from the ECL luminophore when excited by the electrodes, wherein, the ECL luminophore has a lanthanide metal-ligand complex.12-22-2011
20110312731MICROFLUIDIC DEVICE WITH LARGE ANGLE OF COLLECTION OF EMISSION LIGHT - A microfluidic device having a supporting substrate, a hybridization chamber containing probes having a nucleic acid sequence for hybridization with a target nucleic acid sequence to form probe-target hybrids and generate a fluorescence signal in response to an excitation light, and, a photodiode with an active area and an optical axis extending normal to the active area and through the hybridization chamber, wherein, the hybridization chamber has a floor surface positioned parallel to the active area of the photodiode, the floor surface having a centroid and the active area being encompassed within a cone having the centroid at its vertex, and a vertex angle less than 173°.12-22-2011
20110312730LOC DEVICE WITH PARALLEL DNA AND RNA AMPLIFICATION FUNCTIONALITY - A lab-on-a-chip (LOC) device for genetic analysis of a biological sample, the LOC device having an inlet for receiving the sample containing genetic material including DNA and RNA, a supporting substrate, a plurality of reagent reservoirs, a first nucleic acid amplification section for amplifying at least some of the genetic material, and, a second nucleic acid amplification section for amplifying at least some the genetic material in parallel with the first nucleic acid amplification section, wherein, the first nucleic acid amplification section and the second nucleic acid amplification section are both supported on the supporting substrate.12-22-2011
20110312729TEST MODULE USING TRANSITION METAL-LIGAND COMPLEX, ELECTROCHEMILUMINESCENT LUMINOPHORES - A test module for excitation of electrochemiluminescent probes configured to detect target nucleic acid sequences, the test module having an outer casing with an inlet for receiving a fluid containing the target nucleic acid sequences, electrochemiluminescent (ECL) probes having an ECL luminophore for emitting photons when in an excited state and a functional moiety for quenching photon emission from the ECL luminophore by resonant energy transfer, and, electrodes for receiving an electrical pulse to excite the ECL luminophores, such that the ECL probes that have detected one of the target nucleic acid sequences reconfigure such that the functional moiety does not quench the photon emission from the ECL luminophore when excited by the electrodes, wherein, the ECL luminophore has a transition metal-ligand complex.12-22-2011
20110312728MICROFLUIDIC DEVICE WITH NON-IMAGING OPTICS - A microfluidic device having a supporting substrate, a hybridization chamber containing probes having a nucleic acid sequence for hybridization with a target nucleic acid sequence to form probe-target hybrids, the probe-target hybrids being configured to generate a fluorescence signal in response to an excitation light, and, a photodiode with an active area and an optical axis extending normal to the active area and through the hybridization chamber, wherein, the active area is less than 249 microns from the probe-target hybrids.12-22-2011
20110312727LOC DEVICE WITH PARALLEL NUCLEIC ACID AMPLIFICATION FUNCTIONALITY - A lab-on-a-chip (LOC) device for genetic analysis of a biological sample, the LOC device having an inlet for receiving the sample containing genetic material, a supporting substrate, a plurality of reagent reservoirs, a first nucleic acid amplification section for amplifying nucleic acid sequences in the genetic material, and, a second nucleic acid amplification section for amplifying nucleic acid sequences in the genetic material in parallel with the first nucleic acid amplification section, wherein, the first nucleic acid amplification section and the second nucleic acid amplification section are both supported on the supporting substrate.12-22-2011
20110312726MICROFLUIDIC DEVICE WITH CONTROLLABLE SHUNTS INSIDE INTEGRATED PHOTODIODES - A microfluidic device having a probe for hybridization with a target nucleic acid sequence to form a probe-target hybrid, a photodiode having an active area for detecting fluorescence emissions generated by the probe-target hybrid in response to an excitation light, and, a shunt transistor between the photodiode anode and a voltage source, the shunt transistor being configured to remove carriers generated by absorption of photons of the excitation light in the photodiode, wherein, the shunt transistor is encompassed by the active area.12-22-2011
20110312725USB-INTERFACEABLE PORTABLE TEST MODULE FOR ELECTROCHEMILUMINESCENT DETECTION OF TARGETS - A test module for excitation of electrochemiluminescent probes configured to detect target nucleic acid sequences, the test module having an outer casing having a receptacle for receiving a fluid containing the target nucleic acid sequences, electrochemiluminescent (ECL) probes having an ECL luminophore for emitting photons when in an excited state and a functional moiety for quenching photon emission from the ECL luminophore by resonant energy transfer, electrodes for receiving an electrical pulse to excite the ECL luminophores, a detection photosensor for exposure to the photons emitted by the ECL luminophores, control circuitry providing the electrical pulse to the electrodes, and, a universal serial bus (USB) connection such that the outer casing is configured as a USB drive for transmitting data regarding detection of the targets in the fluid to an external device, wherein during use, the ECL probes that have detected one of the target nucleic acid sequences reconfigure such that the functional moiety does not quench the photon emission from the ECL luminophore when excited by the electrodes.12-22-2011
20110312667MICROFLUIDIC TEST MODULE FOR INTERFACING WITH A DESKTOP COMPUTER - A microfluidic test module for analyzing a sample fluid and communicating test results to a desktop computer, the microfluidic test module having an outer casing with a receptacle for receiving the sample, functional sections for processing and analyzing the sample, a communication interface for communication with the desktop computer, and, a controller for operative control of the communication interface.12-22-2011
20110312666MICROFLUIDIC DEVICE WITH TRIGGERED PHOTODETECTION OF FLUORESCING PROBE-TARGET HYBRID - A microfluidic device having a probe for hybridization with a target nucleic acid sequence to form a probe-target hybrid, the probe-target hybrid having a reporting fluorophore for emitting a fluorescence signal in response to an excitation light, a detection photodiode for exposure to the excitation light and the fluorescence signal, and, a trigger photodiode for exposure to the excitation light, the trigger photodiode being configured to activate the detection photodiode after the excitation light has been extinguished.12-22-2011
20110312665LOC WITH DIALYSIS SECTION FOR REMOVING INSOLUBLE SAMPLE CONSTITUENTS FROM A NUCLEIC ACID MIXTURE - A lab-on-a-chip (LOC) device for removing cell debris from a biological sample containing target nucleic acid sequences, the LOC device having a dialysis section with a large constituent channel, a small constituent channel and a plurality of apertures for fluid communication between the large constituent channel and the small constituent channel, the large constituent channel having an upstream end for receiving the biological sample, the biological sample being a liquid carrying a mixture of cell debris and target nucleic acid sequences, and the small constituent channel having a downstream end for connection to a hybridization section with an array of probes for hybridization with the target nucleic acid sequences to form probe-target complexes, wherein, the apertures are sized to allow the target nucleic acid sequences to flow into the small constituent channel but retain the cell debris larger than a threshold size in the large constituent channel.12-22-2011
20110312664MICROFLUIDIC TEST MODULE FOR INTERFACING WITH A DEDICATED READER - A microfluidic test module for analyzing a sample fluid and communicating test results to a dedicated reader purpose built for operating with the microfluidic test module, the microfluidic test module having an outer casing with a receptacle for receiving the sample, functional sections for processing and analyzing the sample, a communication interface for communication with the dedicated reader, and, a controller for operative control of the communication interface.12-22-2011
20110312663MICROFLUIDIC DEVICE WITH TIME DELAYED DETECTION OF FLUORESCENCE FROM HYBRIDIZED PROBES - A microfluidic device having a supporting substrate, a probe having a nucleic acid sequence for hybridization with a target nucleic acid sequence to form a probe-target hybrid, the probe-target hybrid being configured to generate a fluorescence signal in response to an excitation light, and, CMOS circuitry on the substrate, the CMOS circuitry having a photosensor for generating an output signal in response to the fluorescence signal, wherein, the CMOS circuitry is configured to trigger a time delay when the excitation light is deactivated before activating the photosensor.12-22-2011
20110312662LOC DEVICE WITH DIALYSIS SECTION FOR REMOVING CELL DEBRIS FROM A BIOLOGICAL SAMPLE - A lab-on-a-chip (LOC) device for removing cell debris from a biological sample, the LOC device having a dialysis section with a large constituent channel, a small constituent channel and a plurality of apertures for fluid communication between the large constituent channel and the small constituent channel, the large constituent channel having an upstream end for receiving the biological sample, the biological sample being a liquid carrying a mixture of cell debris and target molecules, the small constituent channel having a downstream end for connection to a hybridization section with an array of probes for reaction with the target molecules to form probe-target complexes, wherein, the apertures are sized to allow the target molecules to flow into the small constituent channel but retain the cell debris larger than a threshold size in the large constituent channel.12-22-2011
20110312661MICROFLUIDIC DEVICE WITH ARRAY OF CHAMBERS AND CORRESPONDING DIFFUSION BARRIERS FOR ELECTROCHEMILUMINESCENT DETECTION OF TARGETS - A microfluidic device for detecting target molecules in a fluid, the microfluidic device having an array of chambers, each containing electrochemiluminescent (ECL) probes for reaction with the target molecules to form a probe-target complex, and electrodes positioned in each of the chambers for receiving an electrical pulse, the probe-target complexes being configured to emit a photon of light when excited by current between the electrodes, a flow-path for the fluid containing the targets, wherein, each of the chambers have a chamber inlet for fluid communication between the sample flow-path and the probes within the chamber, the chamber inlet being configured as a diffusion barrier to prevent diffusion of the probe-target complexes between the chambers to an extent that causes erroneous detection results.12-22-2011
20110312660MICROFLUIDIC TEST MODULE FOR INTERFACING WITH A LAPTOP COMPUTER - A microfluidic test module for analyzing a sample fluid and communicating test results to a laptop computer, the microfluidic test module having an outer casing with a receptacle for receiving the sample, functional sections for processing and analyzing the sample, a communication interface for communication with the laptop computer, and, a controller for operative control of the communication interface.12-22-2011
20130184188Integrated Test Device for Optical Detection of Microarrays - This invention relates generally to devices and methods for performing optical and electrochemical assays and, more particularly, to testing devices having an optically readable microspot array and/or an electrochemical detector and to methods of performing microspot arrays and electrochemical assays using such devices. The present invention is particularly useful for performing immunoassays and/or electrochemical assays at the point-of-care.07-18-2013
20110281774Gene Cluster Diagnosis Apparatus - A diagnosis apparatus is provided. A gene chip having a target gene cluster is used with the apparatus. The target gene cluster comprises a plurality of target genes related to a cancer. Thus, a fast, accurate, sensitive and cheap WEnCA-Chipball platform is provided for mass analysis and automatic operation while human error and time for diagnosis are both reduced.11-17-2011
20110312840MICROFLUIDIC DEVICE WITH SAMPLE INLET, ELECTROCHEMILUMINESCENT PROBES AND INTEGRATED PHOTOSENSOR FOR DETECTION OF TARGET SEQUENCES - A microfluidic device having a supporting substrate, a microsystems technologies (MST) layer with a hybridization section that has an array of electrochemiluminescent (ECL) probes for hybridization with target nucleic acid sequences in a fluid, and electrode pairs for receiving an electrical pulse, the ECL probes being configured to emit a photon of light when hybridized with one of the nucleic acid targets and activated by one of the electrodes, and, a photosensor for detecting photons of light from the ECL probes that have hybridized.12-22-2011
20110312839GENETIC ANALYSIS LOC DEVICE FOR ELECTROCHEMILUMINESCENT DETECTION OF TARGET SEQUENCES WITH WORKING ELECTRODE IN CONTACT WITH PHOTOSENSOR - A lab-on-a-chip (LOC) device for detecting a target nucleic acid sequence in a sample, the LOC device having probes with a nucleic acid sequence complementary to the target nucleic acid sequence for forming probe-target hybrids, and an electrochemiluminescent (ECL) luminophore, electrodes for generating an excited state in the ECL luminophore in which the ECL luminophore emits photons of light, and, a photosensor for sensing the photons emitted from the ECL luminophore, wherein, the electrodes have at least one working electrode which causes oxidation or reduction of the luminophore to generate an excited species that emits the photons, the working electrode being positioned immediately adjacent the photosensor.12-22-2011
20110312838MICROFLUIDIC DEVICE WITH ELECTROCHEMILUMINESCENT PROBES AND INTEGRATED PHOTOSENSOR FOR DETECTION OF TARGET MOLECULES - A microfluidic device for detecting target molecules in a fluid, the microfluidic device having reagent reservoirs for adding reagents to the fluid prior to detection of the target molecules, probes for reaction with the target molecules to form probe-target hybrids, and an electrochemiluminescent (ECL) luminophore, electrodes for generating an excited state in the ECL luminophore in which the ECL luminophore emits photons of light, and, a photosensor for sensing the photons emitted from the ECL luminophore.12-22-2011
20110312837LOC DEVICE FOR GENETIC ANALYSIS AND ELECTROCHEMILUMINESCENT DETECTION OF TARGET SEQUENCES - A lab-on-a-chip (LOC) device for detecting a target nucleic acid sequence in a sample, the LOC device having probes with a nucleic acid sequence complementary to the target nucleic acid sequence for forming probe-target hybrids, and an electrochemiluminescent (ECL) luminophore, electrodes for generating an excited state in the ECL luminophore in which the ECL luminophore emits photons of light, and, a photosensor for sensing the photons emitted from the ECL luminophore, wherein, the electrodes are plates of conductive material, the plates having peripheral edges optically coupled to the photosensor.12-22-2011
20110312836MICROFLUIDIC DEVICE FOR ELECTROCHEMILUMINESCENT DETECTION OF TARGET SEQUENCES - A microfluidic device for detecting target nucleic acid sequences in a sample, the microfluidic device having reagent reservoirs for adding reagents to the sample prior to detection of the target nucleic acid sequences, probes with a nucleic acid sequence complementary to the target nucleic acid sequence for forming probe-target hybrids, and an electrochemiluminescent (ECL) luminophore, and, electrodes for generating an excited state in the ECL luminophore in which the ECL luminophore emits photons of light.12-22-2011
20110312835GENETIC ANALYSIS LOC DEVICE WITH ELECTROCHEMILUMINESCENT PROBES AND INTEGRATED PHOTOSENSOR FOR DETECTION OF TARGET SEQUENCES - A lab-on-a-chip (LOC) device for detecting a target nucleic acid sequence in a sample, the LOC device having probes with a nucleic acid sequence complementary to the target nucleic acid sequence for forming probe-target hybrids, and an electrochemiluminescent (ECL) luminophore, electrodes for generating an excited state in the ECL luminophore in which the ECL luminophore emits photons of light, and, a photosensor for sensing the photons emitted from the ECL luminophore.12-22-2011
20110312834LOC DEVICE FOR ELECTROCHEMILUMINESCENT DETECTION USING A RUTHENIUM ORGANIC COMPLEX - A lab-on-a-chip (LOC) device for detecting a target nucleic acid sequence in a sample, the LOC device having a supporting substrate, probes with a nucleic acid sequence complementary to the target nucleic acid sequence for forming probe-target hybrids, and a ruthenium organic complex, electrodes for generating an excited state in the ruthenium organic complex in which the ruthenium organic complex emits photons of light, and, CMOS circuitry for applying a voltage across the electrodes.12-22-2011
20110312833LOC DEVICE FOR ELECTROCHEMILUMINESCENT DETECTION OF TARGET SEQUENCES USING TRANSPARENT ELECTRODES - A lab-on-a-chip (LOC) device for detecting a target nucleic acid sequence in a sample, the LOC device having probes with a nucleic acid sequence complementary to the target nucleic acid sequence for forming probe-target hybrids, and an electrochemiluminescent (ECL) luminophore, and, electrodes for generating an excited state in the ECL luminophore in which the ECL luminophore emits photons of light, wherein, the electrodes are arranged in pairs, one of the electrodes in each electrode pair being a working electrode which causes oxidation or reduction of the luminophore to generate an excited species that emits a photon, the working electrode being transparent to light at the wavelength of the photons emitted by the ECL luminophores.12-22-2011
20110312832LOC DEVICE FOR DETECTION OF TARGET SEQUENCES WITH ELECTROCHEMILUMINESCENT PROBES IN HYBRIDIZATION CHAMBERS - A lab-on-a-chip (LOC) device for detecting a target nucleic acid sequence in a sample, the LOC device having probes with a nucleic acid sequence complementary to the target nucleic acid sequence for forming probe-target hybrids, and an electrochemiluminescent (ECL) luminophore, electrodes for generating an excited state in the ECL luminophore in which the ECL luminophore emits photons of light, and, an array of hybridization chambers, each of the hybridization chambers having a pair of the electrodes respectively and containing a plurality of the probes, the nucleic acid sequence in the probes in each of the hybridization chambers being different to the nucleic acid sequence in at least one other hybridization chamber in the array such that a plurality of target nucleic acid sequences are detectable.12-22-2011
20110312831LOC DEVICE FOR DETECTING TARGET NUCLEIC ACID SEQUENCE WITH ELECTROCHEMILUMINESCENT METALORGANIC COMPLEX - A lab-on-a-chip (LOC) device for detecting a target nucleic acid sequence in a sample, the LOC device having a supporting substrate, probes with a nucleic acid sequence complementary to the target nucleic acid sequence for forming probe-target hybrids, and an electrochemiluminescent (ECL) metalorganic complex, and, electrodes for generating an excited state in the metalorganic complex in which the metalorganic complex emits photons of light, and, CMOS circuitry between the supporting substrate and the probes for applying a voltage across the electrodes.12-22-2011
20110312830GENETIC ANALYSIS LOC DEVICE WITH ELECTROCHEMILUMINESCENT PROBES HAVING A FUNCTIONAL MOIETY FOR QUENCHING PHOTON EMISSIONS CONFIGURED TO CHANGE PROXIMITY TO A LUMINOPHORE UPON FORMING A PROBE-TARGET HYBRID - A lab-on-a-chip (LOC) device for detecting a target nucleic acid sequence in a sample, the LOC device having probes with a nucleic acid sequence complementary to the target nucleic acid sequence for forming probe-target hybrids, an electrochemiluminescent (ECL) luminophore, and a functional moiety for quenching photon emission from the ECL luminophore by resonant energy transfer, and, electrodes for generating an excited state in the ECL luminophore in which the ECL luminophore emits photons of light, wherein during use, the functional moiety changes proximity to the luminophore upon formation of a probe-target hybrid.12-22-2011
20110312829LOC DEVICE FOR GENETIC ANALYSIS AND ELECTROCHEMILUMINESCENT DETECTION OF TARGET SEQUENCES - A lab-on-a-chip (LOC) device for detecting a target nucleic acid sequence in a sample, the LOC device having probes with a nucleic acid sequence complementary to the target nucleic acid sequence for forming probe-target hybrids, and an electrochemiluminescent (ECL) luminophore, and, electrodes for generating an excited state in the ECL luminophore in which the ECL luminophore emits photons of light.12-22-2011
20110312828LOC DEVICE FOR ELECTROCHEMILUMINESCENT DETECTION USING ELECTRODE PAIRS OPTICALLY COUPLED TO PHOTODIODE - A lab-on-a-chip (LOC) device for detecting a target nucleic acid sequence in a sample, the LOC device having probes with a nucleic acid sequence complementary to the target nucleic acid sequence for forming probe-target hybrids, and an electrochemiluminescent (ECL) luminophore, electrode pairs in which one electrode in each of the electrode pairs is a working electrode which causes oxidation or reduction of the luminophore to generate an excited species that emits a photon, and, photodiodes corresponding to each of the electrode pairs respectively, wherein, the photodiodes have a planar active surface area for receiving the light from the luminophore, and the working electrode has a surface area optically coupled to the active surface area of the photodiode, the working electrode being configured such that the optically coupled surface area is greater than 50% of the active surface area of the photodiode.12-22-2011
20110312827GENETIC ANALYSIS LOC DEVICE FOR DETECTION OF TARGET SEQUENCES WITH ELECTROCHEMILUMINESCENT LUMINOPHORE AND FUNCTIONAL MOIETY FOR QUENCHING PHOTON EMISSIONS - A lab-on-a-chip (LOC) device for detecting a target nucleic acid sequence in a sample, the LOC device having a supporting substrate, probes with a nucleic acid sequence complementary to the target nucleic acid sequence for forming probe-target hybrids, an electrochemiluminescent (ECL) luminophore, and a functional moiety for quenching photon emission from the ECL luminophore by resonant energy transfer, electrodes for generating an excited state in the ECL luminophore in which the ECL luminophore emits photons of light, and, CMOS circuitry between the supporting substrate and the probes for applying a voltage across the electrodes.12-22-2011
20110312826TEST MODULE WITH LASER FOR EXCITATION OF OLIGONUCLEOUTIDE PROBES - A test module having an outer casing dimensioned for hand-held portability, the outer casing having an inlet for receiving a biological sample containing a target nucleic acid sequence, probes in the outer casing for hybridization with a target nucleic acid sequence to form probe-target hybrids, the probe-target hybrids being configured to generate a fluorescence signal in response to an excitation light, a laser positioned in the outer casing for generating the excitation light.12-22-2011
20110312825LOC DEVICE FOR ELECTROCHEMILUMINESCENT DETECTION WITH ELECTRODE PAIRS HAVING COMPLEMENTARY AND MUTUALLY INTERDIGITATED FINGER FORMATIONS - A lab-on-a-chip (LOC) device for detecting a target nucleic acid sequence in a sample, the LOC device having probes with a nucleic acid sequence complementary to the target nucleic acid sequence for forming probe-target hybrids, and an electrochemiluminescent (ECL) luminophore, and, electrodes for generating an excited state in the ECL luminophore in which the ECL luminophore emits photons of light, wherein, the electrodes have an anode and a cathode, each having fingers configured for mutual interdigitation.12-22-2011
20110312824TEST MODULE WITH WASTE STORAGE INCORPORATING POROUS ELEMENT - A test module for analyzing fluid containing target nucleic acid sequences, the test module having a casing for hand-held portability, the casing having a receptacle for receiving the fluid, an array of probes for hybridization with target nucleic acid sequences to form probe-target hybrids, and, a waste accumulator for storage of waste material separated from the fluid, wherein, the waste accumulator has a waste reservoir and a porous element to draw the waste material into the waste reservoir by capillary action.12-22-2011
20110312763GENETIC ANALYSIS LOC WITH IN-LOC STORAGE OF ALL REQUIRED REAGENTS - A lab-on-a-chip (LOC) device for genetic analysis having a supporting substrate, a microsystems technology (MST) layer supported on the substrate, the MST layer having an inlet for receiving a biological sample containing target nucleic acid sequences, probes for hybridization with the target nucleic acid sequence to form probe-target hybrids, and, a plurality of reagent reservoirs containing all reagents necessary for performing the diagnostic assay.12-22-2011
20110312823TEST MODULE WITH EXCITATION LIGHT AND MIRRORS FOR SIMULTANEOUS EXCITATION OF OLIGONUCLEOUTIDE PROBES - A test module having an outer casing dimensioned for hand-held portability, the outer casing having an inlet for receiving a biological sample containing a target nucleic acid sequence, probes in the outer casing for hybridization having a nucleic acid sequence for hybridization with a target nucleic acid sequence to form a probe-target hybrid, the probe-target hybrid being configured to generate a fluorescence signal in response to an excitation light, an excitation light for generating the excitation light, and, mirrors positioned in the outer casing for redirecting light from the excitation light to simultaneously illuminate the probes.12-22-2011
20110312822GENETIC ANALYSIS LOC DEVICE FOR ELECTROCHEMILUMINESCENT DETECTION OF TARGET NUCLEIC ACID SEQUENCES - A lab-on-a-chip (LOC) device for detecting a target nucleic acid sequence in a sample, the LOC device having a supporting substrate, probes with a nucleic acid sequence complementary to the target nucleic acid sequence for forming probe-target hybrids, and an electrochemiluminescent (ECL) luminophore, electrodes for generating an excited state in the ECL luminophore in which the ECL luminophore emits photons of light, and, CMOS circuitry between the supporting substrate and the probes for applying a voltage across the electrodes.12-22-2011
20110312821MICROFLUIDIC DEVICE WITH WASTE STORAGE - A microfluidic device having a supporting substrate, a microsystems technologies (MST) layer on the supporting substrate for analyzing a fluid, and, a waste reservoir for storage of waste material separated from the fluid.12-22-2011
20110312820TEST MODULE WITH EXCITATION LIGHT AND PRISMS FOR SIMULTANEOUS EXCITATION OF OLIGONUCLEOUTIDE PROBES - A test module having an outer casing dimensioned for hand-held portability, the outer casing having an inlet for receiving a biological sample containing a target nucleic acid sequence, probes in the outer casing for hybridization having a nucleic acid sequence for hybridization with a target nucleic acid sequence to form a probe-target hybrid, the probe-target hybrid being configured to generate a fluorescence signal in response to an excitation light, an excitation light for generating the excitation light, and, prisms positioned in the outer casing for redirecting light from the excitation light to simultaneously illuminate the probes.12-22-2011
20110312819LOC DEVICE FOR DETECTING TARGET NUCLEIC ACID SEQUENCES USING ELECTROCHEMILUMINESCENCE OF A LUMINOPHORE IN THE PRESENCE OF AN ELECTROCHEMICAL COREACTANT - A lab-on-a-chip (LOC) device for detecting a target nucleic acid sequence in a sample, the LOC device having probes with a nucleic acid sequence complementary to the target nucleic acid sequence for forming probe-target hybrids, and an electrochemiluminescent (ECL) luminophore, electrodes for generating an excited state in the ECL luminophore in which the ECL luminophore emits photons of light, and, an electrochemical coreactant that is present with the luminophore during electrochemiluminescence.12-22-2011
20110312818TEST MODULE WITH EXCITATION LIGHT AND LENS FOR SIMULTANEOUS EXCITATION OF OLIGONUCLEOUTIDE PROBES - A test module having an outer casing dimensioned for hand-held portability, the outer casing having an inlet for receiving a biological sample containing a target nucleic acid sequence, probes in the outer casing for hybridization having a nucleic acid sequence for hybridization with a target nucleic acid sequence to form a probe-target hybrid, the probe-target hybrid being configured to generate a fluorescence signal in response to an excitation light, an excitation light for generating the excitation light, and, a lens positioned in the outer casing for directing light from the excitation light to simultaneously illuminate the probes.12-22-2011
20110312817MICROFLUIDIC TEST MODULE WITH HUMIDITY SENSOR - A test module for analyzing a sample containing nucleic acid sequences, the test module having a casing configured for hand-held portability, an array of probes housed in the casing, the probes being configured to hybridize with target nucleic acid sequences in the sample to form probe-target hybrids, a humidity sensor for sensing the humidity within the casing, wherein, the humidity sensor generates an output for humidity control within the casing.12-22-2011
20110312816TEST MODULE WITH LED FOR SIMULTANEOUS EXCITATION OF OLIGONUCLEOUTIDE PROBES - A test module having an outer casing dimensioned for hand-held portability, the outer casing having an inlet for receiving a biological sample containing a target nucleic acid sequence, probes in the outer casing for hybridization having a nucleic acid sequence for hybridization with a target nucleic acid sequence to form a probe-target hybrid, the probe-target hybrid being configured to generate a fluorescence signal in response to an excitation light, and, an excitation LED for generating the excitation light, the LED positioned in the outer casing for simultaneously illuminating all the probes.12-22-2011
20110312815MICROFLUIDIC DEVICE WITH HUMIDITY SENSOR - A microfluidic device having a supporting substrate, a microsystems technologies (MST) layer on the supporting substrate for processing a fluid sample, and, a humidity sensor for sensing the humidity of an area encompassing the MST layer, wherein, the humidity sensor generates an output for humidity control of the area encompassing the MST layer.12-22-2011
20110312814SINGLE-USE TEST MODULE WITH EXCITATION SOURCE - A single-use test module having an outer casing dimensioned for hand-held portability, the outer casing having an inlet for receiving a biological sample containing a target nucleic acid sequence, probes in the outer casing for hybridization having a nucleic acid sequence for hybridization with a target nucleic acid sequence to form a probe-target hybrid, the probe-target hybrid being configured to generate a fluorescence signal in response to an excitation light, and, an excitation light source.12-22-2011
20110312813SINGLE-USE GENETIC TEST MODULE - A single-use test module for detecting hybridization of probes with nucleic acid sequences, the test module having a sample input for receiving a biological sample with target nucleic acid sequences, a polymerase chain reaction (PCR) section for amplifying the target nucleic acid sequences in the biological sample, an array of probes for hybridization with target nucleic acid sequences in the biological sample, and, circuitry having a photosensor for sensing hybridization between the probes and target nucleic acid sequences in the biological sample, wherein, the circuitry is configured to use outputs from the photosensor to generate a signal indicative of the probes that have hybridized.12-22-2011
20110312812GENETIC TEST MODULE WITH FEEDBACK-CONTROLLED HUMIDIFIER - A test module for processing genetic material in a biological sample, the test module having a casing, a microfluidic device housed in the casing, the microfluidic device having reagents for processing the genetic material, a humidifier for increasing the humidity within the casing, a humidity sensor for sensing the humidity within the casing, wherein, the humidity sensor generates an output used for control of the humidifier.12-22-2011
20110312811LOC DEVICE FOR ELECTROCHEMILUMINESCENT DETECTION OF TARGET SEQUENCES WITH ELECTRODES PROFILED FOR GREATER PERIPHERAL EDGE LENGTH - A lab-on-a-chip (LOC) device for detecting a target nucleic acid sequence in a sample, the LOC device having probes with a nucleic acid sequence complementary to the target nucleic acid sequence for forming probe-target hybrids, and an electrochemiluminescent (ECL) luminophore, electrodes for generating an excited state in the ECL luminophore in which the ECL luminophore emits photons of light, and, a photosensor for sensing the photons emitted from the ECL luminophore, wherein, the electrodes are plates of conductive material, the plates having edge profiles configured such that the length of peripheral edge of each of the plates is greater than 128 microns.12-22-2011
20110312810SINGLE-USE TEST MODULE FOR DETECTION OF HYBRIDIZATION OF TARGETS WITH OLIGONUCLEOTIDE PROBES - A single-use test module having an outer casing dimensioned for hand-held portability, the outer casing having an inlet for receiving a biological sample containing a target nucleic acid sequence, probes in the outer casing for hybridization having a nucleic acid sequence for hybridization with a target nucleic acid sequence to form a probe-target hybrid, the probe-target hybrid being configured to generate a fluorescence signal in response to an excitation light, and, a photosensor to detect the fluorescence signal.12-22-2011
20110312809TEST MODULE WITH HUMIDIFIER - A test module for analyzing genetic material, the test module having a casing configured for hand-held portability, an array of probes housed in the casing, the probes being configured to hybridize with target nucleic acid sequences to form probe-target hybrids, and, a humidifier for increasing the humidity within the casing.12-22-2011
20110312808TEST MODULE WITH CONTROLLED EXPOSURE OF FLUOROPHORES TO EXCITATION LIGHT SOURCE - A test module having an outer casing dimensioned for hand-held portability, the outer casing having an inlet for receiving a biological sample containing a target nucleic acid sequence, and, probes in the outer casing for hybridization having a nucleic acid sequence for hybridization with a target nucleic acid sequence to form a probe-target hybrid, the probe-target hybrid being configured to generate a fluorescence signal in response to an excitation light, and, control circuitry having a photosensor for generating an output signal in response to the fluorescence signal, wherein, the control circuitry is configured to initiate a time delay upon deactivation of the excitation light before activating the photosensor.12-22-2011
20110312807MICROFLUIDIC TEST MODULE WITH A MEMBRANE SEAL TO PREVENT DEHUMIDIFICATION OF THE MIXTURE - A microfluidic test module for analyzing genetic material, the test module having a casing configured for hand-held portability, an array of probes housed in the casing, the probes being configured to hybridize with target nucleic acid sequences to form probe-target hybrids, wherein, the casing has a membrane seal for reducing dehumidification within the casing and providing pressure relief from small air pressure fluctuations.12-22-2011
20110312806MICROFLUIDIC DEVICE WITH HUMIDIFIER - A microfluidic device for analyzing a fluid sample containing target molecules, the microfluidic device having a supporting substrate, a microsystems technologies (MST) layer on the supporting substrate for processing the fluid sample, the MST layer having an array of probes configured to combine with the target molecules to form probe-target complexes, and, a humidifier configured to heat water for localized humidification of an area encompassing the MST layer.12-22-2011
20110312805TEST MODULE WITH TIME DELAYED DETECTION OF FLUORESCENCE FROM HYBRIDIZED PROBE - A test module having an outer casing dimensioned for hand-held portability, the outer casing having an inlet for receiving a biological sample containing a target nucleic acid sequence, probes in the outer casing for hybridization having a nucleic acid sequence for hybridization with a target nucleic acid sequence to form a probe-target hybrid, the probe-target hybrid being configured to generate a fluorescence signal in response to an excitation light, and, control circuitry having a photosensor for generating an output signal in response to the fluorescence signal, wherein, the control circuitry is configured to initiate a time delay upon deactivation of the excitation light before activating the photosensor.12-22-2011
20110312804MICROFLUIDIC DEVICE WITH APERTURE WITH GEOMETRY TO PROMOTE UNPINNED FLOW-THROUGH OF FLUID - A microfluidic device having a channel having an inlet, an outlet and an aperture between the inlet and the outlet, wherein, the aperture has a geometry that does not allow a meniscus of the fluid flow to anchor to the aperture, such that fluid flow from the inlet towards the outlet is uninterrupted.12-22-2011
20110312803SYSTEM FOR VARIABLE LOADING OF REAGENTS INTO MICROFLUIDIC DEVICE FOR GENETIC ANALYSIS - A system for loading reagents into a microfluidic device for genetic analysis, the system having containers with reagents for processing a biological sample in the microfluidic device, an integrated circuit secured to each of the containers respectively, each of the integrated circuits having a container digital memory storing reagent specification data related to the reagent in that container, a microfluidic device for performing a desired genetic test assay, the microfluidic device having a device digital memory, a reagent dispensing apparatus for loading a selection of the reagents into the microfluidic device, the reagent dispensing apparatus having a control microprocessor for accessing the container digital memory and transmitting the specification data to the device digital memory, and, a device reader for accessing the reagent specification data from the device digital memory in order to analyze test assay results from the microfluidic device.12-22-2011
20110312802TEST MODULE WITH PROBES SUSPENDED IN FLUID - A test module having an outer casing having an inlet for receiving a biological sample containing a target nucleic acid sequence, and, probes in the outer casing for hybridization with the target nucleic acid sequence to form probe-target hybrids, the probes each having a fluorophore such that the probe-target hybrids emit a fluorescence signal in response to exposure to an excitation light, wherein, the probes are suspended in a fluid.12-22-2011
20110312801TEST MODULE WITH LANTHANIDE METAL-LIGAND COMPLEX FLUOROPHORE - A test module having an outer casing dimensioned for hand-held portability, the outer casing having an inlet for receiving a biological sample containing a target nucleic acid sequence, and, probes in the outer casing for hybridization with the target nucleic acid sequence to form probe-target hybrids, the probes each having a fluorophore such that the probe-target hybrids emit a fluorescence signal in response to exposure to an excitation light, wherein, the fluorophore is a lanthanide metal-ligand complex.12-22-2011
20110312800TEST MODULE FOR GRAVITY-INDEPENDENT OPERATION - A test module for analyzing genetic material in a biological sample, the test module having an outer casing with a receptacle for receiving the biological sample, functional sections for processing and analyzing the biological sample, a controller for operating the functional sections, and, a flow-path from the receptacle to the functional sections, wherein, the flow-path is configured to draw the sample to be analyzed from the receptacle to the functional sections by capillary action regardless of module orientation relative to gravity.12-22-2011
20110312799USB-INTERFACEABLE PORTABLE TEST MODULE FOR DETECTION OF HYBRIDIZED PROBES - A test module for detecting hybridization of probes with target nucleic acid sequences, the test module having a receptacle for receiving a biological sample with target nucleic acid sequences, an array of probes for hybridization with the target nucleic acid sequences, an excitation light source for illuminating the array of probes, circuitry incorporating a photosensor for sensing a fluorescence emission from any of the probes in the array that have hybridized with the target nucleic acid sequences, wherein, the circuitry is configured to use outputs from the photosensor to generate a signal indicative of the probes that have hybridized and transmit the signal to an external device.12-22-2011
20110312798TEST MODULE WITH INBUILT LANCET - A test module for processing and analyzing a blood sample, the test module having an outer casing with a receptacle for receiving blood, functional sections for processing and analyzing the sample, and, a lancet for collecting the blood sample from a patient.12-22-2011
20110312796TEST MODULE THAT UPDATES MEDICAL DATABASES - A test module for analyzing a sample fluid and communicating data to a medical database, the test module having a receptacle for receiving the sample, functional sections for processing and analyzing the sample, a communication interface for communication with the medical database, and, a controller for operative control of the communication interface.12-22-2011
20110312795DIAGNOSTIC TEST MODULE WITH A LOC WITH INTEGRAL PHOTOSENSOR AND EXCITATION LED FOR DETECTION OF HYBRIDIZATION ASSAY RESULTS - A test module for detecting hybridization of probes with target nucleic acid sequences, the test module having a receptacle for receiving a biological sample with target nucleic acid sequences, an array of probes for hybridization with the target nucleic acid sequences, an excitation light emitting diode (LED) for illuminating the array of probes, CMOS circuitry having a photosensor for sensing a fluorescence emission from any of the probes in the array that have hybridized with the target nucleic acid sequences such that the CMOS circuitry is configured to use outputs from the photosensor to generate a signal indicative of the probes that have hybridized, wherein, the array of probes and the CMOS circuitry are integrated on a lab-on-a-chip (LOC) device contained within the test module.12-22-2011
20110312794TEST MODULE THAT UPDATES EPIDEMIOLOGICAL DATABASES WITH LOCATION DATA - A test module for analyzing a sample fluid and communicating location data to an epidemiological database, the test module having a receptacle for receiving the sample, functional sections for processing and analyzing the sample, a communication interface for communication with the epidemiological database, and, a controller for operative control of the communication interface, wherein, the controller is configured to associate location data with epidemiological data sent to the communication interface for communication with the epidemiological database.12-22-2011
20110312793MICROFLUIDIC TEST MODULE WITH LOW MASS OF PROBES - A microfluidic test module having an outer casing having an inlet for receiving a biological sample containing a target nucleic acid sequence, and, a hybridization chamber mounted in the casing, the hybridization chamber holding a volume of fluid containing probes, the probes each having a nucleic acid sequence for hybridization with the target nucleic acid sequence to form probe-target hybrids, wherein, the mass of the probes in each of the hybridization chambers is less than 270 picograms.12-22-2011
20110312792TEST MODULE THAT UPDATES EPIDEMIOLOGICAL DATABASES - A test module for analyzing a sample fluid and communicating epidemiological data to a database, the test module having a receptacle for receiving the sample, functional sections for processing and analyzing the sample, a communication interface for communication with the epidemiological database, and, a controller for operative control of the communication interface.12-22-2011
20110312791TEST MODULE WITH FAULT-TOLERANT MULTIPLE VALVE ASSEMBLY - A test module for genetic analysis having a casing for hand held portability, an inlet for receiving a liquid containing nucleic acid sequences, an outlet downstream of the inlet, and, a fault-tolerant multiple valve assembly having a plurality of flow-paths extending from the inlet to the outlet and a plurality of valves positioned along each of the flow-paths respectively.12-22-2011
20110312790MICROFLUIDIC TEST MODULE WITH LOW-VOLUME HYBRIDIZATION CHAMBER - A microfluidic test module having an outer casing having an inlet for receiving a biological sample containing a target nucleic acid sequence, and, a hybridization chamber mounted in the casing, the hybridization chamber containing probes having a nucleic acid sequence for hybridization with the target nucleic acid sequence to form probe-target hybrids, wherein, the hybridization chamber has a volume less than 900,000 cubic microns.12-22-2011
20110312789LOC DEVICE WITH FLASH MEMORY - A lab-on-a-chip (LOC) device for analyzing a sample fluid, the LOC device having a supporting substrate, a sample inlet for receiving the sample, a microsystems technology (MST) layer with functional sections for processing and analyzing the sample, and, CMOS circuitry between the supporting substrate and the MST layer, the CMOS circuitry having flash memory for storing program data to operate the functional sections during processing and analysis of the sample.12-22-2011
20110312788GENETIC ANALYSIS LOC WITH THERMAL BOILING-INITIATED VALVE - A lab-on-a-chip (LOC) device for genetic analysis having a supporting substrate, an array of probes for hybridization with target nucleic acid sequences to form probe-target hybrids, a channel for directing a flow of liquid containing the target nucleic acid sequences, the channel having an inlet, an outlet and a meniscus anchor between the inlet and the outlet such that the flow from the inlet towards the outlet stops at the meniscus anchor where the liquid forms a meniscus, and, an actuator valve with a valve heater for heating the meniscus such that the meniscus unpins from the meniscus anchor such that the liquid flow towards the outlet resumes.12-22-2011
20110312787LOC HAVING USB DEVICE DRIVER FOR USE IN A TEST MODULE TO CONTROL USB CONNECTION - A lab-on-a-chip (LOC) device for installation in a test module for analyzing a sample fluid and communicating test results to an external device, the LOC device having a supporting substrate, a sample inlet for receiving the sample, a microsystems technology (MST) layer with functional sections for processing and analyzing the sample, and, CMOS circuitry on the supporting substrate, the CMOS circuitry having a universal serial bus (USB) device driver for operative control of a USB plug in the test module for communication with the external device.12-22-2011
20110312786GENETIC ANALYSIS LOC WITH HYBRIDIZATION ARRAY WITH CALIBRATION CHAMBER CONTAINING PROBE DESIGNED TO BE NONCOMPLEMENTARY TO NUCLEIC ACID SEQUENCES IN THE AMPLICON - A microfluidic device having a supporting substrate, an inlet for receiving a biological sample containing a target nucleic acid sequences, a hybridization chamber containing probes each having a nucleic acid sequence for hybridization with the target nucleic acid sequences to form probe-target hybrids, and, a calibration chamber containing a control probe incapable of hybridization with any sequence in the biological sample.12-22-2011
20110312785SPOTTING DEVICE FOR SPOTTING FIXED ARRAY OF LOCS - A spotting device for contactless spotting of lab-on-a-chip (LOC) devices with oligonucleotide probes, the LOC devices being held in a fixed array on a printed circuit board (PCB) and each having an array of hybridization chambers for receiving the oligonucleotide probes, the probes having nucleic acid sequences that are complementary to target nucleic acid sequences to be identified in a biological sample, the spotting device having a monolithic supporting substrate, an array of reservoirs on one side of the supporting substrate, the reservoirs containing sufficient amount of the oligonucleotide probes suspended in a liquid to spot all the LOC devices on the PCB, and, an array of ejectors on the other side of the supporting substrate, each of the ejectors being configured for fluid communication with a corresponding one of the reservoirs respectively such that the ejectors eject droplets containing the oligonucleotide probes from the corresponding reservoir into one of the hybridization chambers.12-22-2011
20110312784MICROFLUIDIC DEVICE FOR DETECTING TARGETS WITH PROBES, DETECTION PHOTODIODES AND A CALIBRATION PHOTODIODE - A microfluidic device for detecting target molecules in a sample, the microfluidic device having probes for reaction with the target molecules to form probe-target complexes, the probe-target complexes being configured to emit photons when excited, photodiodes for detecting photons emitted by the probe-target complexes and a calibration photodiode for exposure to a calibration source to generate a calibration signal, wherein during use, output from the photodiodes for detecting photons emitted by the probe-target complexes is calibrated by the calibration signal.12-22-2011
20110312783GENETIC ANALYSIS LOC WITH HYBRIDIZATION ARRAY WITH NEGATIVE CONTROL COMPRISING EMPTY CHAMBERS - A microfluidic device having a supporting substrate, an inlet for receiving a biological sample containing target nucleic acid sequences, probes that each have a nucleic acid sequence for hybridization with a respective one of the target nucleic acid sequences to form a probe-target hybrid and emit a fluorescence signal in response to an excitation light, and, photosensors corresponding to each of the probes respectively, and, a control photosensor not corresponding to any of the probes such that the control photosensor does not sense the fluorescence signal of a corresponding probe-target hybrid during correct operation of the microfluidic device.12-22-2011
20110312782OLIGONUCLEOTIDE SPOTTING DEVICE WITH DIGITAL MEMORY - An oligonucleotide spotting device for contactless spotting of probes onto a surface, the probes having nucleic acid sequences that are complementary to target nucleic acid sequences to be identified in a biological sample, the oligonucleotide spotting device having a supporting substrate, an array of ejectors, each having an actuator for ejecting droplets of liquid containing the oligonucleotide probes, and, CMOS circuitry for providing each of the drop ejection actuators with a drive pulse for droplet ejection, wherein, the CMOS circuitry has a digital memory for storing data related to the device.12-22-2011
20110312781LOC WITH DIGITAL MEMORY TO STORE GENETIC DATA UPDATES - A lab-on-a-chip (LOC) device for analyzing a sample fluid, the LOC device having a sample inlet for receiving the sample, a microsystems technology (MST) layer with functional sections for processing and analyzing the sample, and, CMOS circuitry with digital memory for storing genetic data, and configured to download genetic data updates from an external source.12-22-2011
20110312780GENETIC ANALYSIS LOC WITH HYBRIDIZATION ARRAY WITH NEGATIVE CONTROL CHAMBERS INCORPORATING PROBES WITH NO REPORTERS - A microfluidic device having a supporting substrate, an inlet for receiving a biological sample containing target nucleic acid sequences, probes that each have a nucleic acid sequence for hybridization with the target nucleic acid sequences to form probe-target hybrids, a fluorophore and a quencher configured such that the fluorophore emits a fluorescence signal in response to an excitation light and the quencher quenches the fluorescence signal when the probe is not hybridized, but fails to quench the fluorescence signal from the probe-target hybrid, and, a control probe with no fluorophore such that the control probe never emits the fluorescence signal in response to the excitation light.12-22-2011
20110312779OLIGONUCLEOTIDE SPOTTING DEVICE FOR OPERATION UNDER EXTERNAL MICROPROCESSOR CONTROL - An oligonucleotide spotting device for contactless spotting of probes onto a surface, the probes having nucleic acid sequences that are complementary to target nucleic acid sequences to be identified in a biological sample, the oligonucleotide spotting device having a supporting substrate, an array of ejectors, each having an actuator for ejecting droplets of liquid containing the oligonucleotide probes, CMOS circuitry for providing each of the drop ejection actuators with a drive pulse for droplet ejection, and, bond-pads for electrically connecting the CMOS circuitry and an external microprocessor controller for operative control of the array of ejectors.12-22-2011
20110312778GENETIC ANALYSIS LOC WITH HYBRIDIZATION ARRAY WITH NEGATIVE CONTROL CHAMBERS INCORPORATING PROBES DESIGNED TO BE NONCOMPLEMENTARY TO NUCLEIC ACID SEQUENCES IN THE AMPLICON - A lab-on-a-chip (LOC) device for genetic analysis having a supporting substrate, an inlet for receiving a biological sample containing target nucleic acid sequences, an array of probes each having a nucleic acid sequence for hybridization with the target nucleic acid sequences to form probe-target hybrids, and, a control probe designed to be complementary to sequences known to be absent from the biological sample.12-22-2011
20110312777TEST MODULE WITH DIGITAL MEMORY - A test module for analyzing a sample fluid, the test module having a receptacle for receiving the sample, functional sections for processing and analyzing the sample, and, digital memory for storing data and operational information to operatively control the functional sections during processing and analysis of the sample.12-22-2011
20110312776GENETIC ANALYSIS LOC WITH HYBRIDIZATION ARRAY WITH POSITIVE CONTROL CHAMBERS INCORPORATING REPORTERS - A microfluidic device having a supporting substrate, an inlet for receiving a biological sample containing a target nucleic acid sequence, probes that each have a nucleic acid sequence for hybridization with the target nucleic acid sequence to form a probe-target hybrid, a fluorophore and a quencher configured such that the fluorophore emits a fluorescence signal in response to an excitation light and the quencher quenches the fluorescence signal when the probe is not hybridized, but fails to quench the fluorescence signal from the probe-target hybrid, and, a reporter with a fluorophore positioned for exposure to the excitation light simultaneously with the probes, wherein, the reporter always emits the fluorescence signal in response to the excitation light.12-22-2011
20110312775MICROFLUIDIC DEVICE WITH DIGITAL MEMORY - A microfluidic device for analyzing a sample fluid, the microfluidic device having a sample inlet for receiving the sample, a microsystems technology (MST) layer with functional sections for processing and analyzing the sample, and, CMOS circuitry with digital memory for storing data and operational information to operatively control the functional sections during processing and analysis of the sample.12-22-2011
20110312774MICROFLUIDIC DEVICE FOR DIFFUSIVE MIXING IN SMALL CROSS SECTIONAL AREA MICROCHANNEL - A microfluidic device having a supporting substrate, a microsystems technologies (MST) layer on the supporting substrate, the MST layer being configured to combine at least two liquids to form a flow of combined liquids, the MST layer having a diffusion mixing section for diffusive mixing of the at least two liquids, the mixing section having a microchannel defining a flow-path for the combined liquids, wherein, the channel cross section transverse to the flow direction is less than 100,000 square microns.12-22-2011
20110312773MICROFLUIDIC DEVICE WITH FAULT-TOLERANT MULTIPLE VALVE ASSEMBLY - A microfluidic device having an inlet for receiving a liquid flowing through the microfluidic device, an outlet downstream of the inlet, and, a fault-tolerant multiple valve assembly having a plurality of flow-paths extending from the inlet to the outlet and a plurality of valves positioned along each of the flow-paths respectively.12-22-2011
20110312772LOC FOR DETECTION OF HYBRIDIZATION OF NUCLEIC ACID SEQUENCES WITH PCR AMPLIFICATION USING LINKER PRIMERS - A LOC device for amplifying nucleic acid sequences and detecting target nucleic acid sequences, the LOC device having a supporting substrate, restriction enzymes for digesting double stranded nucleic acid sequences at known restriction sites, linker primers for ligation to the restricted ends of the double stranded nucleic acid sequences, heaters for thermally cycling the nucleic acid sequences through a polymerase chain reaction (PCR) process, deoxyribonucleoside triphosphates (dNTPs) for extending the linker primers along the nucleic acid sequences, and, probes for hybridizing with target nucleic acid sequences.12-22-2011
20110312771MICROFLUIDIC DEVICE WITH PWM CONTROLLED INCUBATION SECTION - A microfluidic device having a sample inlet for receiving a fluid sample, an incubation section in fluid communication with the sample inlet, the incubation section having at least one heater for maintaining the fluid sample at an incubation temperature for an incubation period, and, CMOS circuitry to energize the at least one heater with a pulse width modulated (PWM) signal.12-22-2011
20110312770LOC FOR DETECTION OF HYBRIDIZATION OF NUCLEIC ACID SEQUENCES WITH NUCLEIC ACID AMPLIFICATION USING PRIMERS COVALENTLY ATTACHED TO LINEAR PROBES - A LOC device having a supporting substrate, a primer-linked, linear probe with a nucleic acid sequence that matches a target nucleic acid sequence, and a primer for elongating against the target nucleic acid sequence to form a complementary sequence such that during use the nucleic acid sequence matching the target nucleic acid sequence anneals to the complementary sequence to change a fluorescence emission from the probe in response to an excitation light, and, CMOS circuitry on the supporting substrate, the CMOS circuitry having operative control of the excitation light.12-22-2011
20110312769TEST MODULE WITH LOW-VOLUME REAGENT RESERVOIR - A test module for biochemical processing and analysis, the test module having an outer casing dimensioned for hand-held portability, the outer casing having a receptacle for receiving biochemical liquid, and, a reagent reservoir containing a reagent for addition to the biochemical liquid for use in chemical analysis of the biochemical liquid, wherein, the reagent reservoir has a volume less than 1000,000,000 cubic microns.12-22-2011
20110312768LOC FOR DETECTION OF HYBRIDIZATION OF NUCLEIC ACID SEQUENCES WITH PCR AMPLIFICATION USING PRIMERS COVALENTLY ATTACHED TO STEM-AND-LOOP PROBES - A LOC device having a supporting substrate, primer-linked, stem-and-loop probes, each with a nucleic acid sequence that matches one of a plurality of target nucleic acid sequences, and a primer for elongating against the target nucleic acid sequence to form a complementary sequence such that during use the nucleic acid sequence matching the target nucleic acid sequence anneals to the complementary sequence to change a fluorescence emission from the probe in response to an excitation light, a polymerase chain reaction (PCR) section for amplifying the target nucleic acid sequences in the fluid prior to hybridization with the FRET probes, and, CMOS circuitry on the supporting substrate, the CMOS circuitry having operative control of the excitation light.12-22-2011
20110312767MICROFLUIDIC DEVICE WITH INCUBATION SECTION HAVING TEMPERATURE FEEDBACK - A microfluidic device having a sample inlet for receiving a fluid sample, an incubation section for maintaining the fluid sample at an incubation temperature, the incubation section having at least one heater and at least one temperature sensor, wherein, the at least one temperature sensor is configured to provide output for feedback control of the at least one heater.12-22-2011
20110312766MICROFLUIDIC DEVICE WITH FEEDBACK CONTROLLED INCUBATION SECTION - A microfluidic device having a sample inlet for receiving a fluid sample, an incubation section for maintaining the fluid sample at an incubation temperature, the incubation section having at least one heater, and, at least one sensor, wherein, the at least one sensor is configured to provide output for feedback control of the at least one heater.12-22-2011
20110312765GENETIC ANALYSIS LOC WITH LOW OLIGONUCLEOTIDE PROBE MASS AND LOW REAGENT VOLUME - A lab-on-a-chip (LOC) device for genetic analysis having a supporting substrate, a microsystems technology (MST) layer supported on the substrate, the MST layer having an inlet for receiving a biological sample containing target nucleic acid sequences, a hybridization section comprising an array of chambers with probes for hybridization with the target nucleic acid sequences to form probe-target hybrids, and, a reagent reservoir containing a reagent necessary for processing the biological sample prior to hybridization, wherein, the hybridization section contains less than 270 picograms of each probe per chamber and the reagent reservoir containing less than 1000,000,000 cubic microns of the reagent.12-22-2011
20110312764MICROFLUIDIC DEVICE WITH INCUBATOR - A microfluidic device having a supporting substrate, an inlet for receiving a fluid, a microsystems technology (MST) layer for processing the fluid, the MST layer incorporating an incubation section, the incubation section having at least one heater for maintaining the fluid at a predetermined incubation temperature, and, CMOS circuitry between the MST layer and the supporting substrate, the CMOS circuitry being connected to the at least one heater for operative control of the at least one heater.12-22-2011
20110312762LOC FOR DETECTION OF HYBRIDIZATION OF NUCLEIC ACID SEQUENCES WITH FLUORESCENCE RESONANCE ENERGY TRANSFER (FRET) PROBES - A lab-on-a-chip (LOC) device having a supporting substrate, a microsystems technologies (MST) layer with a hybridization section that has an array of fluorescence resonance energy transfer (FRET) probes for hybridization with target nucleic acid sequences in a fluid, and, a photosensor for detecting hybridization of probes within the array of probes.12-22-2011
20110312761TEST MODULE FOR CHEMICALLY AND THERMALLY LYSING CELLS - A test module for lysing cells in a fluid, the test module having an outer casing with receptacle for receiving a fluid containing cells, a lysis reagent reservoir containing a lysis reagent and having a valve, and, a lysis section in fluid communication with the receptacle for holding the fluid during lysis of the cells, the lysis section having a lysis heater for heating the fluid in the lysis section, wherein, the valve is upstream of the lysis section and configured to open as the fluid flows into the lysis section thereby adding the lysis reagent to the fluid.12-22-2011
20110312760REAGENT MICROVIAL WITH AUTHENTICATION INTEGRATED CIRCUIT - A reagent microvial for a reagent dispensing apparatus, the microvial having a container for holding a volume of reagent, an integrated circuit with digital memory for data relating to an identity of the microvial, and, electrical contacts for connection to a control processor in the reagent dispensing apparatus to provide the data to the control processor for comparison with a list of authentic microvial identities.12-22-2011
20110312758TEST MODULE WITH THERMAL LYSIS SECTION - A test module for lysing cells in a fluid, the test module having an outer casing with receptacle for receiving a sample that is a fluid containing cells, a lysis section in fluid communication with the receptacle for holding the fluid during lysis of the cells, and, a lysis heater for heating the fluid in the lysis section to lyse cells, wherein, the test module is configured for drawing the fluid from the receptacle to the lysis section by capillary action.12-22-2011
20110312757REAGENT MICROVIAL WITH DIGITAL MEMORY - A reagent microvial for a reagent dispensing apparatus, the microvial having a container for holding a volume of reagent, a digital memory for data relating to the reagent, a droplet generator for ejecting droplets of the reagent from the container, and, electrical contacts for connection to a control processor in the reagent dispensing apparatus to receive drive pulses for the droplet generator and provide the data to the control processor.12-22-2011
20110312755TEST MODULE WITH CHEMICAL LYSIS SECTION - A test module for lysing cells in a fluid, the test module having an outer casing with receptacle for receiving a fluid containing cells, a lysis reagent reservoir containing a lysis reagent and having an outlet valve, and, a lysis section in fluid communication with the receptacle for holding the fluid during lysis of the cells, wherein, the outlet valve is upstream of the lysis section and configured to open as the fluid flows into the lysis section thereby adding the lysis reagent to the fluid.12-22-2011
20110312752MICROFLUIDIC DEVICE WITH LOW-VOLUME REAGENT RESERVOIR - A microfluidic device for biochemical processing and analysis, the microfluidic device having a supporting substrate, a microsystems technology (MST) layer supported on the substrate, the MST layer having an inlet for receiving biochemical liquid, and, a reagent reservoir containing a reagent necessary for the biochemical processing, wherein, the reagent reservoir has a volume less than 1000,000,000 cubic microns.12-22-2011
20110312751MICROFLUIDIC DEVICE FOR DETECTION OF MITOCHONDRIAL DNA VIA FLUORESCENCE MODULATED BY HYBRIDIZATION - A microfluidic device for analysis of mitochondrial DNA in a sample, the microfluidic device having an inlet for receiving a sample of biological material having cells with mitochondria containing mitochondrial DNA, a lysis section for lysing the mitochondria to release the mitochondrial DNA, fluorescence resonance energy transfer (FRET) probes for hybridization with target nucleic acid sequences in the mitochondrial DNA to form probe-target hybrids, and, a photosensor for detecting the probe-target hybrids.12-22-2011
20110312750MICROFLUIDIC DEVICE WITH TOTAL REAGENT STORAGE - A microfluidic device for biochemical processing and analysis, the microfluidic device having a supporting substrate, a microsystems technology (MST) layer supported on the substrate, the MST layer having an inlet for receiving biochemical liquid, and, a plurality of reagent reservoirs containing all reagents necessary for the biochemical processing, wherein, each of the reagent reservoirs have an outlet with a surface tension valve for retaining the reagent in the reservoir with a reagent meniscus until contact with the biochemical liquid removes the reagent meniscus.12-22-2011
20110312749MICROFLUIDIC DEVICE WITH THERMAL LYSIS SECTION - A microfluidic device for lysing cells in a fluid, the microfluidic device having an inlet channel for receiving a fluid containing cells, a lysis section in fluid communication with the inlet channel for holding the fluid during lysis of the cells, and, a lysis heater for heating the fluid in the lysis section such that the cells lyse, wherein, the inlet channel is configured for filling the lysis section by capillary action.12-22-2011
20110312748LOC WITH INTEGRAL PHOTOSENSOR FOR DETECTION OF HYBRIDIZATION ASSAY RESULTS - A microfluidic device having a supporting substrate, an array of probes for hybridization with a target nucleic acid sequence to form a probe-target hybrid and generate a fluorescence signal in response to an excitation light, and, a photosensor positioned adjacent the array of probes, wherein, the photosensor is configured for sensing which probes within the array of probes generated the fluorescence signal.12-22-2011
20110312747MICROFLUIDIC DEVICE FOR BIOCHEMICAL PROCESSING AND ANALYSIS - A microfluidic device for biochemical processing and analysis, the microfluidic device having a supporting substrate, a microsystems technology (MST) layer supported on the substrate, the MST layer having an inlet for receiving biochemical liquid, and, a reagent reservoir containing a reagent for addition to the biochemical liquid for use in chemical analysis of the biochemical liquid, wherein, the reagent reservoir has an outlet with a surface tension valve for retaining the reagent in the reservoir with a reagent meniscus until contact with the biochemical liquid removes the reagent meniscus.12-22-2011
20110312746MICROFLUIDIC DEVICE WITH CHEMICAL LYSIS SECTION - A microfluidic device for lysing cells in a fluid, the microfluidic device having an inlet for receiving a fluid containing cells, a lysis reagent reservoir containing a lysis reagent and having an outlet valve, and, a lysis section in fluid communication with the inlet for holding the fluid during lysis of the cells, wherein, the outlet valve is upstream of the lysis section and configured to open as the fluid flows into the lysis section thereby adding the lysis reagent to the fluid.12-22-2011
20110312745MICROFLUIDIC TEST MODULE WITH PHOTOSENSOR - A test module for analyzing a sample fluid containing target molecules, the test module having an outer casing with a receptacle for receiving the sample fluid, probes for reaction with the target molecules to form probe-target complexes, the probe-target complexes being configured to emit photons when excited, and, a photosensor for detecting photons emitted by the probe-target complexes.12-22-2011
20110312744MICROFLUIDIC DEVICE FOR AMPLIFYING MITOCHONDRIAL DNA IN A BIOLOGICAL SAMPLE - A microfluidic device for amplifying mitochondrial DNA in a sample, the microfluidic device having an inlet for receiving a sample of biological material having cells with an outer cellular membrane containing mitochondria and a nucleus, the mitochondria having a mitochondrial membrane containing mitochondrial DNA and the nuclei having a nuclear membrane containing nuclear DNA, a lysis section for lysing the outer cellular membrane and the mitochondrial membrane while the nuclear membrane remains intact, and, a nucleic acid amplification section configured for amplifying target nucleic acid sequences in the mitochondrial DNA.12-22-2011
20110312743LOC DEVICE FOR DETECTION OF TARGET NUCLEIC ACID SEQUENCES USING ELECTRODES CONFIGURED FOR ELECTROCHEMILUMINESCENCE OF LUMINOPHORES WITHOUT A COREACTANT - A lab-on-a-chip (LOC) device for detecting target nucleic acid sequences in a fluid, the LOC device having electrochemiluminescent (ECL) probes for detecting the target nucleic acid sequences, each of the probes having an ECL luminophore for emitting photons when in an excited state, a functional moiety for quenching photon emission from the ECL luminophore by resonant energy transfer, and, electrodes for receiving an electrical pulse to excite the ECL luminophores, wherein, the electrodes are arranged into pairs, each having an anode and a cathode, the anode and the cathode being separated by a dielectric gap between 0.4 microns and 2 microns wide.12-22-2011
20110312742SINGLE-USE MICROFLUIDIC DEVICE - A microfluidic device having a supporting substrate, an inlet for receiving a biological sample containing a target nucleic acid sequence, a probe with a nucleic acid sequence for hybridization with the target nucleic acid sequence to form a probe-target hybrid and generate a fluorescence signal in response to an excitation light, and, a photosensor for sensing the fluorescence signal, wherein during use, addition of the biological sample to the inlet prevents fluid communication between a fluid subsequently added to the inlet and the probe.12-22-2011
20110312741MICROFLUIDIC DEVICE FOR ANALYSIS OF MITOCHONDRIAL DNA - A microfluidic device for analysis of mitochondrial DNA in a sample, the microfluidic device having an inlet for receiving a sample of biological material having cells with an outer cellular membrane containing mitochondria and a nucleus, the mitochondria having a mitochondrial membrane containing mitochondrial DNA and the nuclei having a nuclear membrane containing nuclear DNA, a lysis section for lysing the outer cellular membrane and the mitochondrial membrane while the nuclear membrane remains intact, and, probes for hybridization with target nucleic acid sequences in the mitochondrial DNA to form probe-target hybrids.12-22-2011
20110312740MICROFLUIDIC DEVICE WITH CAPILLARY MENISCUS MARCHING VELOCITY SENSOR - A microfluidic device for processing a fluid, the microfluidic device having an inlet for receiving the fluid, functional sections for processing the fluid, a flow-path extending from the inlet into at least some of the functional sections, circuitry for operative control of the functional sections, and, a capillary meniscus marching velocity sensor having a plurality of liquid sensors spaced along the flow-path, each of the liquid sensors having electrodes positioned for contact with the fluid flowing along the flow-path, wherein, the circuitry is configured to provide a voltage across the electrodes such that current above a predetermined threshold is indicative of liquid at the electrodes and used to derive a velocity of the liquid flow front.12-22-2011
20110312739SINGLE-USE TEST MODULE FOR PCR AMPLIFICATION OF TARGETS AND ELECTROCHEMILUMINESCENT DETECTION OF TARGETS - A test module for amplifying and detecting target nucleic acid sequences in a fluid, the test module having an outer casing with a receptacle for receiving a fluid containing the target nucleic acid sequences, a polymerase chain reaction (PCR) section for amplifying the target nucleic acid sequences, an array of electrochemiluminescent (ECL) probes for hybridization with the target nucleic acid sequences to form probe-target hybrids, and, electrodes positioned for receiving an electrical pulse, the probe-target hybrids being configured to emit a photon of light when excited by current between the electrodes, and, a photosensor for detecting the light emitted by the probes, wherein during use, addition of the fluid to the probes prevents subsequent addition of other fluid to the probes.12-22-2011
20110312738MICROFLUIDIC DEVICE WITH LIQUID SENSOR - A microfluidic device for processing a fluid, the microfluidic device having an inlet for receiving the fluid, functional sections for processing the fluid, a flow-path extending from the inlet into at least some of the functional sections, circuitry for operative control of the functional sections, and, a liquid sensor with electrodes positioned for contact with the fluid flowing along the flow-path, wherein, the circuitry is configured to provide a voltage across the electrodes such that current above a predetermined threshold is indicative of liquid at the electrodes.12-22-2011
20110312724LOC DEVICE FOR PATHOGEN DETECTION AND GENETIC ANALYSIS WITH INCUBATION, NUCLEIC ACID AMPLIFICATION AND PREHYBRIDIZATION FILTERING - A lab-on-a-chip (LOC) device for pathogen detection and genetic analysis of a biological sample, the LOC device having an inlet for receiving the sample containing genetic material, a supporting substrate, a plurality of reagent reservoirs, an incubation section downstream of the inlet, the incubation section being in fluid communication with one of the reagent reservoirs containing enzymes for enzymatic reaction with the genetic material, and, a nucleic acid amplification section downstream of the incubation section for amplifying nucleic acid sequences in the genetic material, and, a dialysis section downstream of the nucleic acid amplification section for prehybridization filtration of amplicon produced by the nucleic acid amplification section, the dialysis section being configured to remove cell debris from the amplicon, wherein, the incubation section, the nucleic acid amplification section and the dialysis section are all supported on the supporting substrate.12-22-2011
20110312723GENETIC ANALYSIS LOC FOR NUCLEIC ACID AMPLIFICATION USING NUCLEIC ACID SEQUENCE BASED AMPLIFICATION - A lab-on-a-chip (LOC) device for genetic analysis of a sample containing target nucleic acid sequences, the LOC device having a sample inlet for receiving the sample, a plurality of reagent reservoirs containing dNTPs, primers, reverse transcriptase, RNA polymerase, and buffer solution for addition to the sample to form an amplification mixture, and, a nucleic acid amplification section for maintaining the amplification mixture at a predetermined temperature during isothermal amplification of the target nucleic acid sequences.12-22-2011
20110312722PORTABLE TEST MODULE FOR EXCITATION OF ELECTROCHEMILUMINESCENT PROBES - A portable test module for excitation of electrochemiluminescent probes configured to detect target nucleic acid sequences, the test module having an outer casing configured for hand-held portability, the outer casing having a receptacle for receiving a fluid containing the target nucleic acid sequences, electrochemiluminescent (ECL) probes having an ECL luminophore for emitting photons when in an excited state and a functional moiety for quenching photon emission from the ECL luminophore by resonant energy transfer, and, electrodes for receiving an electrical pulse to excite the ECL luminophores, wherein during use, the ECL probes that have detected one of the target nucleic acid sequences reconfigure such that the functional moiety does not quench the photon emission from the ECL luminophore when excited by the electrodes.12-22-2011
20110312721LOC DEVICE FOR GENETIC ANALYSIS WITH DIALYSIS, INCUBATION, AND NUCLEIC ACID AMPLIFICATION - A lab-on-a-chip (LOC) device for genetic analysis of a biological sample, the LOC device having an inlet for receiving the sample, a supporting substrate, a plurality of reagent reservoirs, a dialysis section for separating cells larger than a predetermined threshold in the sample from smaller constituents, whereby the cells larger than a predetermined threshold include target cells containing genetic material for analysis, an incubation section downstream of the dialysis section, the incubation section being in fluid communication with one of the reagent reservoirs containing enzymes for enzymatic reaction with the genetic material, and, a nucleic acid amplification section downstream of the incubation section for amplifying nucleic acid sequences from the genetic material, wherein, the dialysis section, the incubation section and the nucleic acid amplification section are all supported on the supporting substrate.12-22-2011
20110312720LOC DEVICE FOR GENETIC ANALYSIS WITH DIALYSIS AND NUCLEIC ACID AMPLIFICATION - A lab-on-a-chip (LOC) device for genetic analysis of a biological sample, the LOC device having an inlet for receiving the sample, a supporting substrate, a dialysis section for separating smaller constituents from larger constituents, the smaller constituents being smaller than a predetermined size threshold, and the larger constituents being larger than the predetermined size threshold, and, a nucleic acid amplification section for amplifying nucleic acid sequences in the genetic material, wherein, the dialysis section and the nucleic acid amplification section are both supported on the supporting substrate.12-22-2011
20110312719TEST MODULE WITH INTEGRAL PHOTOSENSOR FOR ELECTROCHEMILUMINESCENT DETECTION OF HYBRIDIZATION - A test module for detecting target nucleic acid sequences in a fluid, the test module having an outer casing having a receptacle for receiving the fluid containing the target nucleic acid sequences, electrochemiluminescent (ECL) probes having an ECL luminophore for emitting photons when in an excited state and a functional moiety for quenching photon emission from the ECL luminophore by resonant energy transfer, electrodes for receiving an electrical pulse to excite the ECL luminophores, and, a detection photosensor for exposure to the photons emitted by the ECL luminophores.12-22-2011
20110312718GENETIC ANALYSIS LOC FOR NUCLEIC ACID AMPLIFICATION USING RECOMBINASE POLYMERASE AMPLIFICATION - A lab-on-a-chip (LOC) device for genetic analysis of a sample containing target nucleic acid sequences, the LOC device having a sample inlet for receiving the sample, a plurality of reagent reservoirs containing dNTPs, primers, recombinase, DNA polymerase and buffer solution for addition to the sample to form an amplification mixture, and, a nucleic acid amplification section for maintaining the amplification mixture at a predetermined temperature during recombinase polymerase amplification (RPA) of the target nucleic acid sequences.12-22-2011
20110312717LOC DEVICE FOR PATHOGEN DETECTION WITH DIALYSIS, INCUBATION AND NUCLEIC ACID AMPLIFICATION - A lab-on-a-chip (LOC) device for detecting pathogens in a biological sample, the LOC device having an inlet for receiving the sample, a supporting substrate, a plurality of reagent reservoirs, a pathogen dialysis section for separating pathogens from constituents smaller than a predetermined threshold, a pathogen lysis section downstream of the pathogen dialysis section for lysing the pathogens with a lysis reagent to release genetic material therein, an incubation section downstream of the pathogen dialysis section, the incubation section being in fluid communication with one of the reagent reservoirs containing enzymes for enzymatic reaction with the genetic material, and, a nucleic acid amplification section downstream of the incubation section for amplifying nucleic acid sequences from the genetic material, wherein, the pathogen dialysis section, the pathogen lysis section, the incubation section and the nucleic acid amplification section are all supported on the supporting substrate.12-22-2011
20110312716GENETIC ANALYSIS LOC FOR NUCLEIC ACID AMPLIFICATION USING AN ISOTHERMAL REACTION - A lab-on-a-chip (LOC) device for genetic analysis of a sample containing target nucleic acid sequences, the LOC device having a sample inlet for receiving the sample, a plurality of reagent reservoirs containing buffer solution, dNTPs, primers, and polymerase for addition to the sample to form an amplification mixture, and, a nucleic acid amplification section for maintaining the amplification mixture at a predetermined temperature during isothermal amplification of the target nucleic acid sequences.12-22-2011
20110312715MICROFLUIDIC TEST MODULE WITH LOW MASS ELECTROCHEMILUMINESCENT PROBE SPOTS - A microfluidic test module for detecting target nucleic acid sequences in a fluid, the test module having an outer casing having an inlet for receiving the fluid containing the target nucleic acid sequences, electrode pairs for receiving an electrical pulse, electrochemiluminescent (ECL) probe spots in contact with each of the electrode pairs respectively, the ECL probe spots containing ECL probes having an ECL luminophore for emitting photons when in an excited state and a functional moiety for quenching photon emission from the ECL luminophore by resonant energy transfer, such that the electrical pulse to the electrode pair excites the ECL luminophores, wherein, the mass of the ECL probes in each of the probe spots is less than 270 picograms.12-22-2011
20110312714GENETIC ANALYSIS LOC FOR AMPLIFICATION OF NUCLEIC ACIDS USING DNA POLYMERASES OF THERMOPHILES - A lab-on-a-chip (LOC) device for genetic analysis of a sample containing target nucleic acid sequences, the LOC device having a sample inlet for receiving the sample, a plurality of reagent reservoirs containing buffer, dNTPs, primers, and polymerase derived from a thermophilic bacterium for addition to the sample to form an amplification mixture, and, a nucleic acid amplification section for controlling the temperature of the amplification mixture during amplification of the target nucleic acid sequences.12-22-2011
20110312713MICROFLUIDIC TEST MODULE WITH LOW-VOLUME HYBRIDIZATION CHAMBERS FOR ELECTROCHEMILUMINESCENT DETECTION OF TARGET NUCLEIC ACID SEQUENCES IN A FLUID - A microfluidic test module for detecting target nucleic acid sequences in a fluid, the test module having an outer casing configured for hand-held portability, the outer casing having an inlet for receiving the fluid containing the target nucleic acid sequences, a hybridization chamber mounted in the casing, the hybridization chamber containing electrochemiluminescent (ECL) probes for detecting the target nucleic acid sequences, each of the ECL probes having an ECL luminophore for emitting photons when in an excited state and a functional moiety for quenching photon emission from the ECL luminophore by resonant energy transfer, and electrodes for receiving an electrical pulse to excite the ECL luminophores, wherein, the hybridization chamber has a volume less than 900,000 cubic microns.12-22-2011
20110312712GENETIC ANALYSIS LOC FOR PCR AMPLIFICATION OF NUCLEIC ACIDS FROM WHOLE BLOOD - A lab-on-a-chip (LOC) device for genetic analysis of a whole blood sample containing target nucleic acid sequences, the LOC device having a sample inlet for receiving the whole blood sample, a plurality of reagent reservoirs containing buffer, dNTPs, primers, and polymerase for addition to the whole blood sample, and, a polymerase chain reaction (PCR) section for thermal cycling the whole blood sample, buffer, dNTPs, primers, and polymerase to amplify the target nucleic acid sequences.12-22-2011
20110312711MICROFLUIDIC DEVICE WITH CONTROLLABLE SHUNTS PERIPHERAL TO INTEGRATED PHOTODIODES - A microfluidic device having a probe for hybridization with a target nucleic acid sequence, a photodiode for detecting fluorescence emissions generated by hybridization of the probe in response to an excitation light, and, a shunt transistor between the photodiode anode and a voltage source, the shunt transistor being configured to remove carriers generated by absorption of photons of the excitation light in the photodiode, wherein, a peripheral edge of the photodiode and a peripheral edge of the shunt transistor contiguously abut each other.12-22-2011
20110312710LOC DEVICE FOR PATHOGEN DETECTION, GENETIC ANALYSIS AND PROTEOMIC ANALYSIS WITH DIALYSIS, CHEMICAL LYSIS, INCUBATION AND NUCLEIC ACID AMPLIFICATION - A lab-on-a-chip (LOC) device for pathogen detection, genetic analysis and proteomic analysis of a biological sample, the LOC device having an inlet for receiving the sample, a supporting substrate, a leukocyte dialysis section for dividing the sample into a leukocyte stream, and a pathogen and erythrocyte stream containing cells and sample constituents smaller than a first size threshold, a pathogen dialysis section for dividing the pathogen and erythrocyte stream into an erythrocyte stream and a pathogen stream containing cells and sample constituents smaller than a second size threshold, a leukocyte lysis section downstream of the leukocyte dialysis section for lysing the leukocytes with a lysis reagent to release genetic material and proteins therein, a leukocyte incubation section downstream of the leukocyte lysis section for enzymatic reaction of the genetic material with enzymes, a leukocyte nucleic acid amplification section downstream of the leukocyte incubation section for amplifying nucleic acid sequences, a pathogen lysis section downstream of the pathogen dialysis section for lysing the pathogens with a lysis reagent to release genetic material and proteins therein, a pathogen incubation section downstream of the pathogen lysis section for enzymatic reaction of the genetic material with enzymes, a pathogen nucleic acid amplification section downstream of the pathogen incubation section for amplifying nucleic acid sequences, an erythrocyte lysis section downstream of the pathogen dialysis section for lysing the erythrocytes with a lysis reagent to release proteins therein, wherein, the leukocyte dialysis section, the pathogen dialysis section, the leukocyte lysis section, the pathogen lysis section, the erythrocyte lysis section, the leukocyte incubation section, the pathogen incubation section, the leukocyte nucleic acid amplification section and the pathogen nucleic acid amplification section are all supported on the supporting substrate.12-22-2011
20110312709LOC DEVICE FOR DETECTING TARGET NUCLEIC ACID SEQUENCES USING ELECTROCHEMILUMINESCENT PROBES AND CALIBRATION PROBES WITH DETECTION PHOTOSENSORS AND CALIBRATION PHOTOSENSORS - A lab-on-a-chip (LOC) device for detecting target nucleic acid sequences in a fluid, the LOC device having electrochemiluminescent (ECL) probes for detecting the target nucleic acid sequences, each of the ECL probes having an ECL luminophore for emitting photons when in an excited state, a functional moiety for quenching photon emission from the ECL luminophore by resonant energy transfer, at least one calibration source configured to generate a calibration emission, electrodes for receiving an electrical pulse to excite the ECL luminophores, at least one detection photodiode for sensing photon emissions from the ECL luminophores and generating a detection output, at least one calibration photodiode for sensing the calibration emission and generating a calibration output, and, CMOS circuitry having a differential circuit for subtracting the calibration output from the detection output.12-22-2011
20110312708GENETIC ANALYSIS LOC FOR ISOTHERMAL AMPLIFICATION OF NUCLEIC ACIDS - A lab-on-a-chip (LOC) device for genetic analysis of a sample containing target nucleic acid sequences, the LOC device having a sample inlet for receiving the sample, a plurality of reagent reservoirs containing buffer, dNTPs, primers, and polymerase for addition to the sample to form an amplification mix, and, a nucleic acid amplification section for controlling the temperature of the amplification mix during isothermal amplification of the target nucleic acid sequences.12-22-2011
20110312707GENETIC ANALYSIS LOC FOR PCR AMPLIFICATION OF NUCLEIC ACIDS - A lab-on-a-chip (LOC) device for genetic analysis of a sample containing target nucleic acid sequences, the LOC device having a sample inlet for receiving the sample, a plurality of reagent reservoirs containing buffer, dNTPs, primers, and polymerase for addition to the sample, and, a polymerase chain reaction (PCR) section for thermal cycling the sample, buffer, dNTPs, primers, and polymerase to amplify the target nucleic acid sequences.12-22-2011
20110312706LOC DEVICE WITH HYBRIDIZATION CHAMBERS CONTAINING PROBES FOR ELECTROCHEMILUMINESCENT DETECTION OF TARGET NUCLEIC ACID SEQUENCES IN A FLUID AND CALIBRATION CHAMBER CONTAINING PROBES SEALED FROM THE FLUID - A lab-on-a-chip (LOC) device for detecting target nucleic acid sequences in a fluid, the LOC device having hybridization chambers containing electrochemiluminescent (ECL) probes for detecting the target nucleic acid sequences, each of the ECL probes having an ECL luminophore for emitting photons when in an excited state, a functional moiety for quenching photon emission from the ECL luminophore by resonant energy transfer, at least one calibration chamber containing probes sealed from contact with the fluid, and, electrodes for receiving an electrical pulse to excite the ECL luminophores.12-22-2011
20110312705TEST MODULE FOR PCR AMPLIFICATION USING LOW PCR MIXTURE VOLUME - A test module for amplifying nucleic acid sequences in a sample fluid, the test module having an outer casing with receptacle for receiving the sample fluid, a polymerase chain reaction (PCR) section with a PCR microchannel for thermally cycling a PCR mixture of the sample fluid, polymerase, dNTP's, primers, and buffer solution to amplify the nucleic acid sequences, wherein, the PCR mixture has a volume less than 400 nanoliters.12-22-2011
20110312704MICROFLUIDIC DEVICE FOR PCR AMPLIFICATION USING LOW PCR MIXTURE VOLUME - A microfluidic device having a sample inlet for receiving a sample of biological material having nucleic acid sequences, a polymerase chain reaction (PCR) section with a PCR microchannel for thermally cycling a PCR mixture of the sample, polymerase, dNTP's and buffer solution to amplify the nucleic acid sequences, the PCR microchannel defining a flow-path for the sample such that flow of the sample along the PCR microchannel is driven by capillary action, wherein, the PCR mixture has a volume less than 400 nanoliters.12-22-2011
20110312703MICROFLUIDIC DEVICE FOR RAPID PCR AMPLIFICATION - A microfluidic device having a supporting substrate, a sample inlet for receiving a sample of biological material having nucleic acid sequences, a polymerase chain reaction (PCR) section for amplifying the nucleic acid sequences, the PCR section having a PCR chamber, and, a heater element for heating the nucleic acid sequences within the PCR chamber, wherein during use, the PCR section generates sufficient amplicon for hybridization with an array of probes in less than 10 minutes.12-22-2011
20110312702LOC DEVICE FOR GENETIC ANALYSIS WITH DIALYSIS, CHEMICAL LYSIS AND NUCLEIC ACID AMPLIFICATION - A lab-on-a-chip (LOC) device for genetic analysis of a biological sample, the LOC device having an inlet for receiving the sample, a supporting substrate, a dialysis section for separating cells larger than a predetermined threshold in the sample from smaller constituents, whereby the cells larger than a predetermined threshold include target cells containing genetic material for analysis, a plurality of reagent reservoirs, a lysis section downstream of the dialysis section for lysing the target cells to release the genetic material therein, the lysis section being in fluid communication with one of the reagent reservoirs containing a lysis reagent for lysing the target cells in the lysis section, and, a nucleic acid amplification section downstream of the lysis section for amplifying nucleic acid sequences from the genetic material, wherein, the dialysis section, the lysis section and the nucleic acid amplification section are all supported on the supporting substrate.12-22-2011
20110312701LOC DEVICE FOR ELECTROCHEMILUMINESCENT DETECTION OF TARGET NUCLEIC ACID SEQUENCES WITH CALIBRATED PHOTODETECTION OF PROBES IN HYBRIDIZATION ARRAY - A lab-on-a-chip (LOC) device for detecting target nucleic acid sequences in a fluid, the LOC device having electrochemiluminescent (ECL) probes for detecting the target nucleic acid sequences, each of the probes having an ECL luminophore for emitting photons when in an excited state, a functional moiety for quenching photon emission from the ECL luminophore by resonant energy transfer, electrodes for receiving an electrical pulse to excite the ECL luminophores, detection photodiodes for exposure to the photons emitted by the ECL luminophores, and, at least one calibration photodiode for exposure to ambient light, wherein during use, a difference between the output from any of the detection photodiode and the output from the calibration photodiode is compared to a predetermined threshold difference such that output differences greater than the predetermined threshold indicate the target is present.12-22-2011
20110312700MICROFLUIDIC DEVICE WITH PWM CONTROLLED PCR HEATER - A microfluidic device having a supporting substrate, a sample inlet for receiving a sample of biological material having nucleic acid sequences, a microsystems technology (MST) layer having a polymerase chain reaction (PCR) section for amplifying the nucleic acid sequences, the PCR section having at least one heater for thermally cycling the nucleic acid sequences through a denaturing phase, an annealing phase and a primer extension phase, and, CMOS circuitry between the MST layer and the supporting substrate, the CMOS circuitry configured to energize the at least one heater with a pulse width modulated (PWM) signal during the thermal cycling.12-22-2011
20110312699MICROFLUIDIC DEVICE WITH ON-CHIP SEMICONDUCTOR CONTROLLED PCR SECTION - A microfluidic device having a supporting substrate, a sample inlet for receiving a sample of biological material having nucleic acid sequences, a microsystems technology (MST) layer having a polymerase chain reaction (PCR) section for amplifying the nucleic acid sequences, the PCR section having at least one heater for thermally cycling the nucleic acid sequences through a denaturation phase, an annealing phase and a primer extension phase, and, CMOS circuitry between the MST layer and the supporting substrate, the CMOS circuitry being connected to the at least one heater for operative control of the at least one heater during the thermal cycling.12-22-2011
20110312698MICROFLUIDIC DEVICE WITH PCR SECTION HAVING SHORT THERMAL CYCLE TIMES - A microfluidic device having a sample inlet for receiving a sample of biological material having nucleic acid sequences, a polymerase chain reaction (PCR) section for amplifying the nucleic acid sequences, the PCR section having at least one heater for thermally cycling the nucleic acid sequences through a denaturation phase, an annealing phase and a primer extension phase, wherein during use, the PCR section has a thermal cycle time of less than 30 seconds.12-22-2011
20110312697MICROFLUIDIC DEVICE WITH TEMPERATURE FEEDBACK CONTROLLED PCR SECTION - A microfluidic device having a sample inlet for receiving a sample of biological material having nucleic acid sequences, a polymerase chain reaction (PCR) section for amplifying the nucleic acid sequences, the PCR section having at least one heater, and, at least one temperature sensor, wherein, the at least one temperature sensor is configured to provide output for feedback control of the at least one heater.12-22-2011
20110312696LOC DEVICE FOR PATHOGEN DETECTION WITH DIALYSIS, CHEMICAL LYSIS AND NUCLEIC ACID AMPLIFICATION - A lab-on-a-chip (LOC) device for detecting pathogens in a biological sample, the LOC device having an inlet for receiving the sample, a supporting substrate, a dialysis section for separating pathogens from larger constituents in the sample, a plurality of reagent reservoirs, a lysis section downstream of the dialysis section for lysing the pathogens to release genetic material therein, the lysis section being in fluid communication with one of the reagent reservoirs containing a lysis reagent for lysing the cells in the lysis section, and, a nucleic acid amplification section downstream of the lysis section for amplifying nucleic acid sequences in the genetic material, wherein, the dialysis section, the lysis section and the nucleic acid amplification section are all supported on the supporting substrate.12-22-2011
20110312695LOC DEVICE WITH HYBRIDIZATION CHAMBER ARRAY WITH POSITIVE CONTROL CHAMBER CONTAINING ELECTROCHEMILUMINESCENT REPORTER - A lab-on-a-chip (LOC) device for detecting target nucleic acid sequences in a fluid, the LOC device having electrochemiluminescent (ECL) probes for detecting the target nucleic acid sequences, each of the probes having an ECL luminophore for emitting photons when in an excited state, a functional moiety for quenching photon emission from the ECL luminophore by resonant energy transfer, electrodes for receiving an electrical pulse to excite the ECL luminophores, hybridization chambers containing the probes for detection of the targets, and a pair of the electrodes, and, at least one positive control chamber containing positive control probes that have the ECL luminophore but not the functional moiety for quenching photon emission.12-22-2011
20110312694MICROFLUIDIC DEVICE WITH DELAY-TRIGGERED PHOTODETECTION OF FLUORESCENT PROBE-TARGET HYBRID - A microfluidic device having a supporting substrate, a probe having a nucleic acid sequence for hybridization with a target nucleic acid sequence to form a probe-target hybrid, the probe-target hybrid being configured to generate a fluorescence signal in response to an excitation light, and, CMOS circuitry on the substrate, the CMOS circuitry having a photosensor for generating an output signal in response to the fluorescence signal, wherein, the CMOS circuitry is configured to initiate a time delay upon deactivation of the excitation light before activating the photosensor.12-22-2011
20110312693MICROFLUIDIC DEVICE WITH FEEDBACK CONTROLLED PCR SECTION - A microfluidic device having a sample inlet for receiving a sample of biological material having nucleic acid sequences, a polymerase chain reaction (PCR) section for amplifying the nucleic acid sequences, the PCR section having at least one heater, and, at least one sensor, wherein, the at least one sensor is configured to provide output for feedback control of the at least one heater.12-22-2011
20110312692LOC DEVICE FOR PATHOGEN DETECTION WITH DIALYSIS, THERMAL LYSIS AND NUCLEIC ACID AMPLIFICATION - A lab-on-a-chip (LOC) device for detecting pathogens in a biological sample, the LOC device having an inlet for receiving the sample, a supporting substrate, a dialysis section for separating pathogens from larger constituents in the sample, a lysis section downstream of the dialysis section for lysing the pathogens to release genetic material therein, the lysis section having a lysis chamber and a heater for lysing the pathogens while the sample is in the lysis chamber, and, a nucleic acid amplification section downstream of the lysis section for amplifying nucleic acid sequences in the genetic material, wherein, the dialysis section, the lysis section and the nucleic acid amplification section are all supported on the supporting substrate.12-22-2011
20110312691LOC DEVICE WITH ELECTROCHEMILUMINESCENT PROBES INCLUDING POSITIVE AND NEGATIVE CONTROL PROBES - A lab-on-a-chip (LOC) device for detecting target nucleic acid sequences in a fluid, the LOC device having electrochemiluminescent (ECL) probes for detecting the target nucleic acid sequences, each of the probes having an ECL luminophore for emitting photons when in an excited state, a functional moiety for quenching photon emission from the ECL luminophore by resonant energy transfer, at least one positive control probe that has one of the ECL luminophores but not the functional moiety for quenching photon emission, at least one negative control probe that does not have one of the ECL luminophores, and, electrodes for receiving an electrical pulse to excite the ECL luminophores.12-22-2011
20110312690MICROFLUIDIC DEVICE WITH PCR SECTION HAVING TWO-DIMENSIONAL CONTROL OF INPUT HEAT FLUX DENSITY - A microfluidic device having a sample inlet for receiving a sample of biological material having nucleic acid sequences, a polymerase chain reaction (PCR) section for amplifying the nucleic acid sequences, the PCR section having a microchannel configured to have a plurality of mutually parallel, adjacent channel sections, and a plurality of elongate heaters positioned end to end along each of the channel sections, wherein, each of the heaters are independently operable for two-dimensional control of heat flux density to the PCR section.12-22-2011
20110312689MICROFLUIDIC DEVICE WITH SENSOR-TRIGGERED PHOTODETECTION OF FLUORESCENT PROBE-TARGET HYBRID - A microfluidic device having a supporting substrate, an array of probes, each of the probes having a nucleic acid sequence for hybridization with a target nucleic acid sequence to form a probe-target hybrid, the probe-target hybrid being configured to generate a fluorescence signal in response to an excitation light, and, CMOS circuitry on the substrate, the CMOS circuitry having an array of photodiodes for sensing deactivation of the excitation light and generating an output signal in response to the fluorescence signals from the probe-target hybrids within the array of probes.12-22-2011
20110312688MICROFLUIDIC DEVICE WITH PCR CHAMBER BETWEEN SUPPORTING SUBSTRATE AND HEATER - A microfluidic device having a supporting substrate, a sample inlet for receiving a sample of biological material having nucleic acid sequences, a polymerase chain reaction (PCR) section for amplifying the nucleic acid sequences, the PCR section having a PCR chamber, and, a heater element for heating the nucleic acid sequences within the PCR chamber, wherein, the PCR chamber is between the heater element and the supporting substrate.12-22-2011
20110312687LOC DEVICE WITH LOW VOLUME HYBRIDIZATION CHAMBERS AND REAGENT RESERVOIRS FOR GENETIC ANALYSIS USING ELECTROCHEMILUMINESCENT TARGET DETECTION - A lab-on-a-chip (LOC) device for detecting target nucleic acid sequences in a fluid, the LOC device having electrochemiluminescent (ECL), resonance energy transfer probes for hybridization with the target nucleic acid sequences, each of the probes containing a sequence complementary to the target nucleic acid sequence, and an ECL luminophore for emitting photons when in an excited state, a functional moiety for quenching photon emission from the ECL luminophore by resonant energy transfer, electrodes for receiving an electrical pulse to excite the ECL luminophores, hybridization chambers containing the probes for hybridization with the targets, at least one of the heaters and a pair of the electrodes, and, a reagent reservoir containing a reagent for addition to the fluid, wherein, the hybridization chambers each have a volume less than 900,000 cubic microns and the reagent reservoir has a volume less than 1,000,000,000 cubic microns.12-22-2011
20110312686MICROFLUIDIC DEVICE WITH ELONGATE PCR CHAMBERS - A microfluidic device having a sample inlet for receiving a sample of biological material having nucleic acid sequences, a polymerase chain reaction (PCR) section for amplifying the nucleic acid sequences, the PCR section having at least one elongate PCR chamber having a longitudinal extent much greater than its lateral dimensions, and, at least one elongate heater element for heating the nucleic acid sequences within the elongate PCR chamber, wherein, the elongate heater element extends parallel with the longitudinal extent of the PCR chamber.12-22-2011
20110312685LOC DEVICE FOR PCR USING ADAPTOR PRIMERS AND TARGET DETECTION USING ELECTROCHEMILUMINESCENT RESONANT ENERGY TRANSFER PROBES - A lab-on-a-chip (LOC) device for amplifying and detecting target nucleic acid sequences, the LOC device having restriction enzymes for restricting double stranded oligonucleotides at known ligation sites, linker molecules for attaching to the ligated ends of the double stranded oligonucleotides, heaters for thermally cycling the oligonucleotides through a polymerase chain reaction (PCR) process, primers for annealing to the linker molecules on single strands of the oligonucleotides after denaturation, deoxyribonucleoside triphosphates (dNTPs) for extending the primers along the single strand oligonucleotides, and, electrodes for receiving an electrical pulse to excite the ECL luminophores.12-22-2011
20110312684LOC DEVICE FOR PATHOGEN DETECTION WITH DIALYSIS, LYSIS AND NUCLEIC ACID AMPLIFICATION - A lab-on-a-chip (LOC) device for detecting pathogens in a biological sample, the LOC device having an inlet for receiving the sample, a supporting substrate, a dialysis section for separating pathogens from larger constituents in the sample, a lysis section downstream of the dialysis section for lysing the pathogens to release genetic material therein, and, a nucleic acid amplification section downstream of the lysis section for amplifying nucleic acid sequences in the genetic material, wherein, the dialysis section, the lysis section and the nucleic acid amplification section are all supported on the supporting substrate.12-22-2011
20110312683MICROFLUIDIC TEST MODULE FOR INTERFACING WITH TABLET COMPUTER - A microfluidic test module for analyzing a sample fluid and communicating test results to a tablet computer, the microfluidic test module having an outer casing with a receptacle for receiving the sample, functional sections for processing and analyzing the sample, a communication interface for communication with the tablet computer, and, a controller for operative control of the communication interface.12-22-2011
20110312682LOC DEVICE FOR AMPLIFYING AND DETECTING TARGET NUCLEIC ACID SEQUENCES USING ELECTROCHEMILUMINESCENT RESONANT ENERGY TRANSFER, STEM-AND-LOOP PROBES WITH COVALENTLY ATTACHED PRIMERS - A lab-on-a-chip (LOC) device for amplifying and detecting target nucleic acid sequences, the LOC device having electrochemiluminescent (ECL), resonant energy transfer, stem-and-loop probes for hybridization with the target nucleic acid sequences, each of the probes having a loop portion containing a sequence complementary to the target nucleic acid sequence, an ECL luminophore for emitting photons when in an excited state, a functional moiety for quenching photon emission from the ECL luminophore by resonant energy transfer, and a covalently attached primer for extension along a complementary sequence denatured from the target nucleic acid sequence to replicate the target nucleic acid sequence, heaters for thermally cycling the target nucleic acid sequences through a polymerase chain reaction (PCR), in which the covalently attached primers anneal to oligonucleotides containing the target nucleic acid sequences, and, electrodes for receiving an electrical pulse to excite the ECL luminophores, wherein during use, replicating the target nucleic acid sequence causes the loop portion to open such the complementary nucleic acid sequence therein hybridizes to the target nucleic acid sequence and the ECL luminophore is moved away from the functional moiety.12-22-2011
20110312681LOC DEVICE WITH DIALYSIS SECTION FOR REMOVING ERYTHROCYTES FROM BLOOD - A lab-on-a-chip (LOC) device for analyzing leukocytes in a blood sample, the LOC device having a supporting substrate, an inlet for receiving a sample of blood, a dialysis section for separating erythrocytes from leukocytes in the blood, and, a microsystems technology (MST) layer for analyzing the leukocytes, wherein, the inlet, the dialysis section and the MST layer are all supported on the supporting substrate.12-22-2011
20110312680LOC DEVICE FOR DETECTING HYBRIDIZATION OF TARGET NUCLEIC ACID SEQUENCES WITH ELECTROCHEMILUMINESCENT RESONANT ENERGY TRANSFER, PRIMER-LINKED, LINEAR PROBES - A lab-on-a-chip (LOC) device for detecting hybridization of target nucleic acid sequences, the LOC device having electrochemiluminescent (ECL), resonant energy transfer, primer-linked, linear probes for hybridization with the target nucleic acid sequences to form probe-target hybrids, each of the probes having a linear portion containing the target nucleic acid sequence, a primer for extension along the target nucleic acid sequence to form a nucleic acid sequence complementary to the target, an ECL luminophore for emitting photons when in an excited state, and a functional moiety for quenching photon emission from the ECL luminophore by resonant energy transfer, and, electrodes for receiving an electrical pulse to excite the ECL luminophores, wherein during use, replicating the target nucleic acid sequence causes the linear portion to dissociate from the functional moiety such that the complementary nucleic acid sequence therein hybridizes to the target nucleic acid sequence and photons emitted by the ECL luminophore are not quenched.12-22-2011
20110312679MICROFLUIDIC DEVICE WITH SURFACE-MICROMACHINED DIALYSIS SECTION - A microfluidic device for removing cell debris from a biological sample, the microfluidic device having a dialysis section with a large constituent channel, a small constituent channel and a plurality of apertures for fluid communication between the large constituent channel and the small constituent channel, the large constituent channel having an upstream end for receiving the biological sample, the biological sample being a liquid carrying a mixture of cell debris and target molecules, the small constituent channel having a downstream end for connection to a hybridization section with an array of probes for reaction with the target molecules to form probe-target complexes, wherein, the apertures are spaced along the large constituent channel at a spacing between 1 micron and 10 microns and each of the apertures is sized to allow the target molecules to flow into the small constituent channel but retain the cell debris larger than a threshold size in the large constituent channel.12-22-2011
20110312678TEST MODULE WITH MICROFLUIDIC DEVICE HAVING DIALYSIS DEVICE, LOC AND INTERCONNECTING CAP - A test module for analyzing a sample fluid containing target molecules, the test module having an outer casing with a receptacle for receiving the sample fluid, and, a microfluidic device having: a dialysis device in fluid communication with the receptacle and configured to separate the target molecules from other constituents of the sample, a lab-on-a-chip (LOC) device for analyzing the target molecules, and, a cap overlaying the LOC device and the dialysis device for establishing fluid communication between the LOC device and the dialysis device.12-22-2011
20110312677LOC DEVICE FOR DETECTION OF TARGETS WITH ELECTROCHEMILUMINESCENT RESONANT ENERGY TRANSFER PROBES - A lab-on-a-chip (LOC) device for detecting target molecules in a fluid, the LOC device having an array of electrochemiluminescent (ECL) probes for reaction with the target molecules to form probe-target complexes, and, electrodes for receiving an electrical pulse, wherein, the probes each have an ECL luminophore that emits a photon when excited by current between the electrodes, and a functional moiety for quenching photon emission from the ECL luminophore by resonant energy transfer.12-22-2011
20110312676LOC DEVICE WITH INTEGRAL DRIVER FOR EXCITATION OF ELECTROCHEMILUMINESCENT LUMINOPHORES - A lab-on-a-chip (LOC) device for exciting electrochemiluminescent luminophores, the LOC device having a supporting substrate, an array of electrochemiluminescent (ECL) probes for reaction with the target molecules to form probe-target complexes, the probes each having a luminophore for emitting photons of light when in an excited state, electrodes for receiving an electrical pulse to excite the luminophores with current between the electrodes, and, CMOS circuitry for controlling the electrical pulse transmitted to the electrodes, wherein, the CMOS circuitry is between the supporting substrate and the array of probes.12-22-2011
20110312675DIALYSIS DEVICE WITH FLOW-CHANNEL STRUCTURE FOR CAPILLARY-DRIVEN FLUIDIC PROPULSION WITHOUT TRAPPED AIR BUBBLES - A dialysis device with capillary-driven, flow-channel structure for dialysis of a fluid containing constituents of different sizes, the dialysis device having a first channel configured to fill with the fluid by capillary action, a second channel configured to fill with the fluid by capillary action, a plurality of fluid connections between the first channel and the second channel, each of the fluid connections being configured to pin a meniscus of the fluid that arrests capillary flow between the first channel and the second channel, a bypass channel between the first channel and the second channel, the bypass channel joining the second channel upstream of the plurality of fluid connections and is configured for uninterrupted capillary driven flow from the first channel to the second channel, wherein during use, flow from the bypass channel reaches the meniscus pinned at each of the fluid connections after the meniscus has formed such that the flow sequentially removes each of the menisci and sample flow from the first channel to the second channel is via the plurality of fluid connections as well as the bypass channel.12-22-2011
20110312674LOC DEVICE WITH INTEGRAL PHOTOSENSOR FOR ELECTROCHEMILUMINESCENCE BASED DETECTION OF TARGETS - A lab-on-a-chip (LOC) device for detecting target molecules in a fluid, the LOC device having an array of electrochemiluminescent (ECL) probes for reaction with the target molecules to form probe-target complexes, electrodes for receiving an electrical pulse, the probe-target complexes being configured to emit a photon of light when excited by current between the electrodes, and, a photosensor for detecting light emitted by the probe-target complexes.12-22-2011
20110312673DIALYSIS DEVICE WITH MULTI-LAYER STRUCTURE - A dialysis device for dialysis of a fluid containing constituents of different sizes, the dialysis device having a first layer of material defining a first channel and a second channel, the first channel configured for receiving the fluid which contains constituents of different sizes, a second layer having a plurality of apertures open to the first channel and at least one fluid connection leading from the apertures to the second channel for establishing fluid communication between the first channel and the second channel, wherein, the apertures are sized in accordance with a predetermined size threshold such that the constituents flowing to the second channel are smaller constituents that are smaller than the predetermined size threshold, and the constituents retained in the first channel include larger constituents which are larger than the predetermined size threshold.12-22-2011
20110312672MICROFLUIDIC ASSEMBLY WITH TEST MODULE AND DETACHABLE INDICATOR MODULE - A microfluidic assembly for detecting a target molecule in a sample fluid and indicating a positive or negative result, the microfluidic assembly having a test module having an outer casing with a receptacle for receiving the sample, functional sections for processing the sample and detecting the target molecules, a communication interface a controller for transmitting an output signal from one or more of the functional sections, and, an indicator module for detachable engagement with the communication interface, the indicator module having an indicator for providing an indication of the target molecule being present in the fluid sample.12-22-2011
20110312671SINGLE USE MICROFLUIDIC DEVICE WITH PHOTOSENSOR FOR ELECTROCHEMILUMINESCENT DETECTION OF TARGETS - A microfluidic device for detecting target molecules in a fluid, the microfluidic device having an array of electrochemiluminescent (ECL) probes for reaction with the target molecules to form a probe-target complexes, electrodes for receiving an electrical pulse, the probe-target complexes being configured to emit a photon of light when excited by current between the electrodes, and, a photosensor for detecting the light emitted by the probes, wherein during use, addition of the fluid to the probes prevents subsequent addition of other fluid to the probes.12-22-2011
20110312670MICROFLUIDIC TEST MODULE FOR INTERFACING WITH AN EBOOK READER - A microfluidic test module for analyzing a sample fluid and communicating test results to an ebook reader, the microfluidic test module having an outer casing with a receptacle for receiving the sample, functional sections for processing and analyzing the sample, a communication interface for communication with the ebook reader, and, a controller for operative control of the communication interface.12-22-2011
20110312669MICROFLUIDIC DEVICE WITH ELECTROCHEMILUMINESCENT PROBES AND PHOTOSENSOR WITH LARGE ANGLE OF COLLECTION FOR PROBE EMITTTED LIGHT - A microfluidic device for detecting target molecules in a fluid, the microfluidic device having a hybridization chamber containing electrodes and probes for hybridization with target molecules to form probe-target complexes and generate an electrochemiluminescence (ECL) signal in response to an electrical current between the electrodes, and, a photodiode with an active area and an optical axis extending normal to the active area and through the hybridization chamber, wherein, the hybridization chamber has a floor surface positioned parallel to the active area of the photodiode, the floor surface having a centroid and the active area being encompassed within a cone having the centroid at its vertex, and a vertex angle less than 174°.12-22-2011
20110312668LOC WITH DIALYSIS SECTION FOR RETAINING INSOLUBLE SAMPLE CONSTITUENTS AFTER AMPLIFICATION AND PASSING SOLUBLE CONSTITUENTS TO A DETECTION SECTION - A lab-on-a-chip (LOC) device for removing cell debris from a biological sample containing target nucleic acid sequences, the LOC device having an amplification section for amplifying the nucleic acid sequences, a dialysis section with a large constituent channel, a small constituent channel and a plurality of apertures for fluid communication between the large constituent channel and the small constituent channel, the large constituent channel configured to receive the biological sample after nucleic acid amplification in the amplification section, the biological sample being a liquid mixture of the cell debris and the target nucleic acid sequences and the apertures are sized to allow the target nucleic acid sequences to flow into the small constituent channel while the cell debris larger than a threshold size is retained in the large constituent channel, and, an array of probes in fluid communication with the small constituent channel for hybridization with the target nucleic acid sequences to form probe-target hybrids.12-22-2011
20110312659MICROFLUIDIC DEVICE WITH HYBRIDIZATION CHAMBERS AND CORRESPONDING DIFFUSION BARRIERS - A microfluidic device having a sample flow-path for a biological sample containing target nucleic acid sequences, an array of hybridization chambers each containing probes for hybridization with the target nucleic acid sequences, each of the hybridization chambers having a chamber inlet for fluid communication between the sample flow-path and the probes, wherein, the chamber inlet is configured as a diffusion barrier to prevent diffusion of hybridized probes between the hybridization chambers to an extent that causes erroneous hybridization detection results.12-22-2011
20110312658LOC DEVICE WITH DIALYSIS SECTION FOR CONCENTRATING NUCLEATED CELLS IN A BIOLOGICAL SAMPLE - A lab-on-a-chip (LOC) device for concentrating nucleated cells in a biological sample, the LOC device having an inlet for receiving a sample of biological material including nucleated cells and other constituents, the nucleated cells all being larger than a predetermined threshold, a dialysis section for concentrating the nucleated cells into a portion of the sample such that the remainder of the sample contains the other constituents smaller than the predetermined threshold, and, a microsystems technology (MST) layer for processing the nucleated cells.12-22-2011
20110312657MICROFLUIDIC TEST MODULE FOR INTERFACING WITH A MOBILE TELEPHONE - A microfluidic test module for analyzing a sample fluid and communicating test results to a mobile telephone, the microfluidic test module having an outer casing with a receptacle for receiving the sample, functional sections for processing and analyzing the sample, a communication interface for communication with the mobile telephone, and, a controller for operative control of the communication interface.12-22-2011
20110312656MICROFLUIDIC DEVICE FOR PCR AND PROBE HYBRIDIZATION - A microfluidic device having a sample inlet for receiving a sample of biological material containing target nucleic acid sequences, and, a microsystems technologies (MST) layer with a polymerase chain reaction (PCR) section for amplifying the target nucleic acid sequences, and an array of probes for hybridization with the target nucleic acid sequences.12-22-2011
20110312655MICROFLUIDIC DEVICE FOR PCR, PROBE HYBRIDIZATION AND ELECTROCHEMILUMINESCENT DETECTION OF PROBE-TARGET HYBRIDS - A microfluidic device for amplifying and detecting target nucleic acid sequences in a sample, the microfluidic device having a polymerase chain reaction (PCR) section for amplifying the target nucleic acid sequences, and, a hybridization section that has an array of electrochemiluminescent (ECL) probes for hybridization with the target nucleic acid sequences to form probe-target hybrids, and a plurality of electrodes for receiving an electrical pulse such that the probe-target hybrids emit a photon of light.12-22-2011
20110312654APPARATUS FOR LOADING OLIGONUCLEOTIDE SPOTTING DEVICES AND SPOTTING OLIGONUCLEOTIDE PROBES - An apparatus for loading oligonucleotide spotting devices and spotting oligonucleotide probes, the apparatus having a plurality of oligonucleotide vials, each with a droplet dispenser, a mounting surface for detachably mounting an oligonucleotide spotting device, a chuck for detachably mounting the oligonucleotide spotting device adjacent the mounting surface, and, a control processor for operative control of the oligonucleotide vials, the oligonucleotide spotting device when mounted in the chuck and movement of the mounting surface relative to the oligonucleotide vials, and the oligonucleotide spotting device, wherein, the control processor is configured to activate the droplet dispensers, and move the oligonucleotide spotting device into registration with the oligonucleotide vials.12-22-2011
20110312653MICROFLUIDIC DEVICE WITH LOW-VOLUME HYBRIDIZATION CHAMBERS - A microfluidic device having a supporting substrate, a microsystems technologies (MST) layer with a hybridization section that has an array of hybridization chambers, each containing a different probe type for hybridization with target nucleic acid sequences, wherein, each of the hybridization chambers has a volume less than 900,000 cubic microns.12-22-2011
20110312652MICROFLUIDIC DEVICE WITH LOW-VOLUME ELECTROCHEMILUMINESCENCE-BASED PROBE SPOTS - A microfluidic device for detecting target nucleic acid sequences in a sample, the microfluidic device having an array of hybridization chambers, each of the hybridization chambers containing electrode pairs for receiving an electrical pulse and electrochemiluminescent (ECL) probes for hybridization with the target nucleic acid sequences, the ECL probes being configured to emit a photon of light when hybridized with one of the nucleic acid targets and excited by current between the electrodes, wherein, the mass of the probes in each of the hybridization chambers is less than 270 picograms.12-22-2011
20110312651MICROFLUIDIC DEVICE WITH LOW MASS PROBE SPOTS - A microfluidic device having a supporting substrate, a microsystems technology (MST) layer overlying the supporting substrate for processing a fluid containing target nucleic acid sequences, the MST layer having a plurality of probe spots, each of the probe spots containing probes for hybridization with the target nucleic acid sequences, wherein, the mass of the probes in each of the probe spots is less than 270 picograms.12-22-2011
20110312650MICROFLUIDIC DEVICE WITH OPTICALLY TRANSPARENT HYBRIDIZATION CHAMBERS FOR ELECTROCHEMILUMINESCENT DETECTION OF TARGETS - A microfluidic device for detecting target nucleic acid sequences in a sample, the microfluidic device having an array of hybridization chambers, each containing electrochemiluminescent (ECL) probes for hybridization with the target nucleic acid sequences, and electrode pairs for receiving an electrical pulse, the ECL probes being configured to emit a photon of light when hybridized with one of the nucleic acid targets and activated by one of the electrodes, wherein, the hybridization chambers each have a wall section that is optically transparent to the light emitted by the ECL probes.12-22-2011
20110312649MICROFLUIDIC DEVICE WITH OPTICALLY TRANSPARENT HYBRIDIZATION CHAMBERS - A microfluidic device having a supporting substrate, a microsystems technology (MST) layer overlying the supporting substrate for processing a fluid containing target nucleic acid sequences, the MST layer having an array of hybridization chambers, each containing probes for hybridization with the target nucleic acid sequences, the probes being configured to emit a fluorescence signal in response to an excitation light upon hybridization, wherein, the hybridization chamber has a wall section that is optically transparent to the fluorescence signal.12-22-2011
20110312648MICROFLUIDIC DEVICE FOR GENETIC AND MITOCHONDRIAL ANALYSIS OF A BIOLOGICAL SAMPLE - A microfluidic device for analysis of genetic DNA and mitochondrial DNA in a sample, the microfluidic device having an inlet for receiving a sample of biological material having cells with an outer cellular membrane containing mitochondria and a nucleus, the mitochondria has a mitochondrial membrane containing mitochondrial DNA and the nuclei have a nuclear membrane containing nuclear DNA, a first lysis section for lysing the outer cellular membrane and the mitochondrial membrane while the nuclear membrane remains intact, a second lysis section for lysing the nuclear membrane, mitochondrial probes downstream of the first lysis section for hybridization with target nucleic acid sequences in the mitochondrial DNA to form probe-target hybrids, and, nuclear probes downstream of the second lysis second for hybridization with target nucleic acid sequences in the nuclear DNA to form probe-target hybrids.12-22-2011
20110312647MICROFLUIDIC DEVICE WITH TEMPERATURE FEEDBACK CONTROLLED HYBRIDIZATION CHAMBERS - A microfluidic device having a supporting substrate, a microsystems technology (MST) layer overlying the supporting substrate for processing a fluid containing target nucleic acid sequences, the MST layer having an array of hybridization chambers, each containing probes for hybridization with the target nucleic acid sequences, a temperature sensor for sensing the temperature at the array of hybridization chambers, and, a hybridization heater for heating the array of hybridization chambers, wherein during use, output from the temperature sensor is used for feedback control of the hybridization heater.12-22-2011
20110312646LOC DEVICE FOR SEPARATING CONSTITUENTS OF INTERMEDIATE SIZE FROM LARGER AND SMALLER CONSTITUENTS IN A BIOLOGICAL SAMPLE - A lab-on-a-chip (LOC) device to separate constituents of intermediate size from larger and smaller constituents in a biological sample, the LOC device having an inlet for receiving the biological sample including large constituents sized above an upper threshold, small constituents sized smaller than a lower threshold and intermediate constituents sized between the upper and the lower thresholds, a first channel in fluid communication with the inlet, first apertures sized to correspond to the upper threshold, a second channel in fluid communication with the first channel via the first apertures, second apertures sized to correspond to the lower threshold, a third channel in fluid communication with the second channel via the second apertures, and, a microsystems technology (MST) layer for analyzing the large, intermediate and or small constituents separately, wherein during use, the intermediate and the small constituents flow into the second channel via the first apertures while the large constituents are retained in the first channel, and the small constituents flow into the third channel while the intermediate constituents are retained in the second channel12-22-2011
20110312645MICROFLUIDIC DEVICE WITH TEMPERATURE FEEDBACK CONTROLLED HYBRIDIZATION CHAMBERS FOR ELECTROCHEMILUMINESCENT DETECTION OF TARGETS - A microfluidic device for detecting target nucleic acid sequences in a sample, the microfluidic device having a supporting substrate, a microsystems technology (MST) layer overlying the supporting substrate for processing the sample, the MST layer having an array of hybridization chambers, each containing electrochemiluminescent (ECL) probes for hybridization with the target nucleic acid sequences, and electrode pairs for receiving an electrical pulse, the ECL probes being configured to emit a photon of light when hybridized with one of the nucleic acid targets and activated by one of the electrodes, an array of temperature sensors positioned such that at least one of the temperature sensors corresponds to each of the hybridization chambers respectively, and, heaters for heating each of the hybridization chambers, such that, output from the temperature sensors is used for feedback control of the heaters.12-22-2011
20110312644MICROFLUIDIC DEVICE FOR SIMULTANEOUS DETECTION OF MULTIPLE CONDITIONS IN A PATIENT - A microfluidic device for simultaneous detection of multiple conditions in a patient, the microfluidic device having an inlet for receiving a sample of biological material drawn from the patient, a microsystems technologies (MST) layer with a detection section having an array of probes for reaction with target molecules in the sample to form probe-target complexes, the target molecules being indicative of medical conditions in the patient, and, a photosensor for detecting the probe-target complexes, wherein, the array of probes has more than 1000 probes.12-22-2011
20110312643MICROFLUIDIC DEVICE FOR DETECTION OF HYBRIDIZATION OF NUCLEIC ACID TARGETS - A microfluidic device having a supporting substrate, a microsystems technologies (MST) layer with a hybridization section that has an array of probes for hybridization with target nucleic acid sequences to form probe-target hybrids, and, a photosensor for detecting the probe-target hybrids.12-22-2011
20110312642MICROFLUIDIC DEVICE FOR DETECTION OF NUCLEIC ACID TARGETS WITH ELECTROCHEMILUMINESCENT PROBES - A microfluidic device for detecting a target nucleic acid sequence in a sample, the microfluidic device having a sample inlet for receiving the sample, probes with a nucleic acid sequence complementary to the target nucleic acid sequence for forming probe-target hybrids, and an electrochemiluminescent (ECL) luminophore, and, electrodes for generating an excited state in the ECL luminophore in which the ECL luminophore emits photons of light, wherein, the sample inlet draws the sample along a fluid flow-path leading to the probes by capillary action.12-22-2011
20110312641MICROFLUIDIC DEVICE WITH SAMPLE INLET AND PROBE HYBRIDIZATION SECTION - A microfluidic device for detecting hybridization of probes with target nucleic acid sequences, the microfluidic device having a sample inlet for receiving a fluid sample with target nucleic acid sequences, an array of probes for hybridization with the target nucleic acid sequences, and, a flow-path from the sample inlet to the array, wherein, the flow-path is configured to draw the fluid sample from the sample inlet to the probes by capillary action.12-22-2011
20110312640MICROFLUIDIC DEVICE WITH PHOTOSENSOR - A microfluidic device having a supporting substrate, a microsystems technologies (MST) layer for processing a fluid sample, and, a photosensor adjacent the MST layer for detecting photons emitted from the MST layer.12-22-2011
20110312639LOC DEVICE WITH DIALYSIS SECTION FOR SEPARATING LEUKOCYTES AND PATHOGENS FROM BLOOD - A lab-on-a-chip (LOC) device to separate pathogens and leukocytes from a blood sample for analysis, the LOC device having a sample inlet for receiving the blood including pathogens, leukocytes and other constituents, a dialysis section for separating the pathogens into a first portion of the sample and separating the leukocytes into a second portion of the sample such that the remainder of the sample has constituents smaller than the leukocytes and larger than the pathogens, and, a microsystems technology (MST) layer for analyzing the pathogens and the leukocytes.12-22-2011
20110312638LOC DEVICE FOR PATHOGEN DETECTION AND GENETIC ANALYSIS WITH DIALYSIS AND NUCLEIC ACID AMPLIFICATION - A lab-on-a-chip (LOC) device for pathogen detection and genetic analysis of a biological sample, the LOC device having an inlet for receiving the sample, a supporting substrate, a plurality of reagent reservoirs, a dialysis section for separating pathogens and cells larger than a predetermined threshold in the sample from smaller constituents, whereby the pathogens and cells larger than the predetermined threshold contain genetic material for analysis, a nucleic acid amplification section downstream of the dialysis section for amplifying nucleic acid sequences from the genetic material, wherein, the dialysis section and the nucleic acid amplification section are all supported on the supporting substrate.12-22-2011
20110312637LOC DEVICE WITH DIALYSIS SECTION FOR SEPARATING PATHOGENS FROM A BIOLOGICAL SAMPLE - A lab-on-a-chip (LOC) device to separate pathogens from a biological sample for analysis, the LOC device having a supporting substrate, an inlet for receiving the sample including pathogens and other constituents larger than the pathogens, a dialysis section for separating the pathogens into a portion of the sample, and, a microsystems technology (MST) layer for separately analyzing the pathogens, wherein, the inlet, the dialysis section and the MST layer are all supported on the supporting substrate.12-22-2011
20110312636LOC DEVICE WITH DIALYSIS SECTION FOR SEPARATING LEUKOCYTES FROM BLOOD - A lab-on-a-chip (LOC) device to for analyzing leukocytes in a blood sample, the LOC device having a supporting substrate, an inlet for receiving a sample of blood including leukocytes and erythrocytes, a dialysis section for separating at least some of the erythrocytes from the leukocytes, and, a microsystems technology (MST) layer for separately analyzing the leukocytes, wherein, the inlet, the dialysis section and the MST layer are all supported on the supporting substrate.12-22-2011
20110312635MICROFLUIDIC DEVICE WITH FLOW-CHANNEL STRUCTURE FOR CAPILLARY-DRIVEN FLUIDIC PROPULSION WITHOUT TRAPPED AIR BUBBLES - A microfluidic device for processing a fluid sample, the microfluidic device having a first channel configured to fill with the sample by capillary action, a second channel configured to fill with the sample by capillary action, a plurality of fluid connections between the first channel and the second channel, each of the fluid connections being configured to pin a meniscus of the sample that arrests capillary flow between the first channel and the second channel, a bypass channel between the first channel and the second channel, the bypass channel joining the second channel upstream of the plurality of fluid connections and is configured for uninterrupted capillary driven flow from the first channel to the second channel, wherein during use, flow from the bypass channel reaches the meniscus pinned at each of the fluid connections after the meniscus has formed such that the flow sequentially removes each of the menisci and sample flow from the first channel to the second channel is via the plurality of fluid connections as well as the bypass channel.12-22-2011
20110312634MICROFLUIDIC DEVICE WITH LAMINAR STRUCTURE - A microfluidic device having a supporting substrate, a microsystems technology (MST) layer overlying the supporting substrate, the MST layer defining MST channels for fluid flow within the MST layer, a cap overlying the MST layer, the cap defining cap channels for fluid flow within the cap and reservoirs for holding a quantity of fluid, wherein, the MST channels and the cap channels are in fluid communication.12-22-2011
20110312633MICROFLUIDIC DEVICE WITH DIALYSIS SECTION - A microfluidic device for dialysis of biological material, the microfluidic device having a sample inlet for receiving a sample of biological material that has constituents of different sizes, a dialysis section for separating smaller constituents from larger constituents, the smaller constituents being smaller than a predetermined size threshold, and the larger constituents being larger than the predetermined size threshold, and, a microsystems technology (MST) layer for separately processing the smaller constituents and/or the larger constituents.12-22-2011
20110312632MICROFLUIDIC DEVICE WITH PCR SECTION AND DIFFUSION MIXER - A microfluidic device having a sample inlet for receiving a sample of biological material having nucleic acid sequences, a polymerase chain reaction (PCR) section for amplifying the nucleic acid sequences, a reagent reservoir containing a reagent, and, a diffusion mixing section for mixing the nucleic acid sequences with the reagent, the diffusion mixing section having a microchannel defining a tortuous flow-path having a length sufficient for diffusive mixing of the reagent and the sample, wherein during use, the sample flows from the sample inlet to the PCR section via the diffusion mixing section.12-22-2011
20110312631GENETIC ANALYSIS LOC WITH NON-SPECIFIC NUCLEIC ACID AMPLIFICATION SECTION AND SUBSEQUENT SPECIFIC AMPLIFICATION OF PARTICULAR SEQUENCES IN A SEPARATE SECTION - A lab-on-a-chip (LOC) device for genetic analysis of a sample containing target nucleic acid sequences, the LOC device having a sample inlet for receiving the sample, a plurality of reagent reservoirs containing dNTP's, primers, polymerase and buffer solution for addition to the sample, a first nucleic acid amplification section for thermal control of the sample to amplify the target nucleic acid sequences, and, a second nucleic acid amplification section for thermal control of amplicon from the first nucleic acid amplification section to further amplify the target nucleic acid sequences.12-22-2011
20110312630LOC DEVICE FOR PATHOGEN DETECTION, GENETIC ANALYSIS AND PROTEOMIC ANALYSIS WITH DIALYSIS, CHEMICAL LYSIS, INCUBATION AND TANDEM NUCLEIC ACID AMPLIFICATION - A lab-on-a-chip (LOC) device for pathogen detection, genetic analysis and proteomic analysis of a biological sample, the LOC device having an inlet for receiving the sample, a supporting substrate, a leukocyte dialysis section for dividing the sample into a leukocyte stream, and a pathogen and erythrocyte stream containing cells and sample constituents smaller than a first size threshold, a pathogen dialysis section for dividing the pathogen and erythrocyte stream into an erythrocyte stream and a pathogen stream containing cells and sample constituents smaller than a second size threshold, a leukocyte lysis section downstream of the leukocyte dialysis section for lysing the leukocytes with a lysis reagent to release genetic material and proteins therein, a leukocyte incubation section downstream of the leukocyte lysis section for enzymatic reaction of the genetic material with enzymes, a pathogen lysis section downstream of the pathogen dialysis section for lysing the pathogens with a lysis reagent to release genetic material and proteins therein, a pathogen incubation section downstream of the pathogen lysis section for enzymatic reaction of the genetic material with enzymes, an erythrocyte lysis section downstream of the pathogen dialysis section for lysing the erythrocytes with a lysis reagent to release proteins therein, a first leukocyte nucleic acid amplification section downstream of the leukocyte incubation section for amplifying nucleic acid sequences, a second leukocyte nucleic acid amplification section downstream of the first leukocyte nucleic acid amplification section for amplifying nucleic acid sequences, a first pathogen nucleic acid amplification section downstream of the pathogen incubation section for amplifying nucleic acid sequences, and, a second pathogen nucleic acid amplification section downstream of the first pathogen nucleic acid amplification for amplifying nucleic acid sequences, wherein, the leukocyte dialysis section, the pathogen dialysis section, the leukocyte lysis section, the pathogen lysis section, the leukocyte incubation section, the pathogen incubation section, the first and second leukocyte nucleic acid amplification sections and the first and second pathogen nucleic acid amplification sections are all supported on the supporting substrate.12-22-2011
20110312629MICROFLUIDIC DEVICE WITH DIALYSIS SECTION HAVING STOMATA TAPERING COUNTER TO FLOW DIRECTION - A microfluidic device for removing cell debris from a biological sample, the microfluidic device having a dialysis section with a large constituent channel and a small constituent channel, and a series of stoma for fluid communication between the large constituent channel and the small constituent channel, the large constituent channel having an upstream end for receiving the biological sample, the biological sample being a liquid carrying a mixture of cell debris and target molecules, the small constituent channel having a downstream end for connection to a hybridization section with an array of probes for reaction with the target molecules to form probe-target complexes, wherein, each of the stoma is tapered in a counter-flow direction such that each have a small opening to the large constituent channel and a large opening to the small constituent channel, the small openings being sized to allow the target molecules to flow into the small constituent channel but retain the cell debris larger than a threshold size in the large constituent channel.12-22-2011
20110312628MICROFLUIDIC DEVICE WITH MST LAYER AND OVERLYING CAP - A microfluidic device having a supporting substrate, a microsystems technologies (MST) layer on the supporting substrate, a cap overlying the MST layer, the cap having a plurality of fluidic connections between the cap and the MST layer for fluid flow from the MST layer to the cap and fluid flow from the cap to the MST layer.12-22-2011
20110312627TEST MODULE WITH MICROFLUIDIC DEVICE HAVING LOC AND DIALYSIS DEVICE FOR SEPARATING PATHOGENS FROM OTHER CONSTITUENTS IN A BIOLOGICAL SAMPLE - A test module for concentrating pathogens in a biological sample, the test module having an outer casing with a receptacle for receiving the sample, a dialysis device in fluid communication with the receptacle and configured to separate the pathogens from other constituents in the sample, and, a lab-on-a-chip (LOC) device being in fluid communication with the dialysis device and configured to analyze the pathogens.12-22-2011
20110312626TEST MODULE INCORPORATING SPECTROMETER - A test module having an outer casing having a receptacle for receiving a biological sample, an excitation source mounted in the outer casing for sequentially illuminating the biological sample with different wavelengths of light, and, a photosensor positioned to detect the different wavelengths of light transmitted through the biological sample, wherein during use, the photosensor output signal is used to generate a spectrogram for analysis of a characteristic of the biological sample.12-22-2011
20110312625LOC DEVICE FOR GENETIC ANALYSIS WITH DIALYSIS, CHEMICAL LYSIS AND TANDEM NUCLEIC ACID AMPLIFICATION - A lab-on-a-chip (LOC) device for genetic analysis of a biological sample, the LOC device having an inlet for receiving the sample, a supporting substrate, a dialysis section for separating cells larger than a predetermined threshold in the sample from smaller constituents, whereby the cells larger than a predetermined threshold include target cells containing genetic material for analysis, a plurality of reagent reservoirs, a lysis section downstream of the dialysis section for lysing the target cells to release the genetic material therein, the lysis section being in fluid communication with one of the reagent reservoirs containing a lysis reagent for lysing the target cells in the lysis section, a first nucleic acid amplification section downstream of the lysis section for amplifying first nucleic acid sequences in the genetic material, and, a second nucleic acid amplification section downstream of the first nucleic acid amplification section for amplifying second nucleic acid sequences in the amplicon from the first nucleic acid amplification section, wherein, the dialysis section, the lysis section, the first nucleic acid amplification section and the second nucleic acid amplification section are all supported on the supporting substrate.12-22-2011
20110312624MICROFLUIDIC DEVICE WITH FLOW-CHANNEL STRUCTURE HAVING ACTIVE VALVE FOR CAPILLARY-DRIVEN FLUIDIC PROPULSION WITHOUT TRAPPED AIR BUBBLES - A microfluidic device for processing a fluid sample, the microfluidic device having a first channel configured to fill with the sample by capillary action, a second channel configured to fill with the sample by capillary action, a plurality of fluid connections between the first channel and the second channel, one of the fluid connections having an active valve to arrest the sample flow into the second channel and the remaining fluid connections each being configured to pin a meniscus of the sample that arrests capillary flow between the first channel and the second channel, the fluid connection with the active valve being upstream of the remaining fluid connections, wherein during use, the sample flow into the second channel is initiated by activation of the active valve such that the sample flow in the second channel progressively removes the meniscus at each of the meniscus anchors.12-22-2011
20110312623LOC DEVICE FOR PATHOGEN DETECTION WITH DIALYSIS, THERMAL LYSIS, NUCLEIC ACID AMPLIFICATION AND PREHYBRIDIZATION FILTERING - A lab-on-a-chip (LOC) device for detecting pathogens in a biological sample, the LOC device having an inlet for receiving the sample, a supporting substrate, a first dialysis section for separating pathogens from larger constituents in the sample, a lysis section downstream of the dialysis section for lysing the pathogens to release genetic material therein, the lysis section having a lysis chamber and a heater for lysing the pathogens while the sample is in the lysis chamber, a nucleic acid amplification section downstream of the lysis section for amplifying nucleic acid sequences in the genetic material, and, a second dialysis section downstream of the nucleic acid amplification section for prehybridization filtration of amplicon produced by the nucleic acid amplification section, the second dialysis section being configured to remove cell debris from the amplicon, wherein, the first dialysis section, the lysis section, the nucleic acid amplification section and the second dialysis section are all supported on the supporting substrate.12-22-2011
20110312622MICROFLUIDIC DEVICE WITH LOW-VOLUME HYBRIDIZATION CHAMBERS FOR ELECTROCHEMILUMINESCENT DETECTION OF TARGET SEQUENCES - A microfluidic device for detecting target nucleic acid sequences in a sample, the microfluidic device having an array of hybridization chambers, each containing electrochemiluminescent (ECL) probes for hybridization with the target nucleic acid sequences, and electrode pairs for receiving an electrical pulse, the ECL probes being configured to emit a photon of light when hybridized with one of the nucleic acid targets and activated by one of the electrodes, wherein, the hybridization chambers each have a volume less than 900000 cubic microns.12-22-2011
20130190213Microfluidic Methods, Devices, and Systems for Fluid Handling - In one aspect of the invention, systems, methods, and devices are provided for handling liquid. In some embodiments, such systems, methods, and devices are used to process reagent biochemical reactions.07-25-2013
20120289434SYSTEMS AND METHODS FOR DEVELOPING DIAGNOSTIC TESTS BASED ON BIOMARKER INFORMATION FROM LEGACY CLINICAL SAMPLE SETS - Disclosed are systems and methods for developing diagnostic tests (e.g., detection, screening, monitoring, and prognostic tests) based on biomarker information from legacy clinical sample sets, for which only small sample volumes (e.g., about 0.05 to about 1.0 mL or less per sample) are typically available. For example, biomarkers (e.g., about 10, 50, 100, 150, 200, 300, or more) may be detected in the clinical samples through the use of single molecule detection and each biomarker may be detected in an assay that includes about 1 μL or less of a legacy clinical sample.11-15-2012
20120028852MICROFLUIDIC DEVICE FOR SIMULTANEOUSLY CONDUCTING MULTIPLE ANALYSES - Provided is a rotatable microfluidic device for conducting simultaneously two or more assays. The device includes a platform which can be rotated, a first unit which is disposed at one portion of the platform and detects a target material from a sample using surface on which a capture probe selectively binds to the target material is attached, and a second unit which is disposed at another portion of the platform and detects a target material included in the sample by a different reaction from the reaction conducted in the first unit.02-02-2012
20120028851MICROFLUIDIC DEVICE FOR SIMULTANEOUSLY CONDUCTING MULTIPLE ANALYSES - Provided is a rotatable microfluidic device for conducting simultaneously two or more assays. The device includes a platform which can be rotated, a first unit which is disposed at one portion of the platform and detects a target material from a sample using surface on which a capture probe selectively binds to the target material is attached, and a second unit which is disposed at another portion of the platform and detects a target material included in the sample by a different reaction from the reaction conducted in the first unit.02-02-2012
20120028850MICROFLUIDIC DEVICE FOR SIMULTANEOUSLY CONDUCTING MULTIPLE ANALYSES - Provided is a rotatable microfluidic device for conducting simultaneously two or more assays. The device includes a platform which can be rotated, a first unit which is disposed at one portion of the platform and detects a target material from a sample using surface on which a capture probe selectively binds to the target material is attached, and a second unit which is disposed at another portion of the platform and detects a target material included in the sample by a different reaction from the reaction conducted in the first unit.02-02-2012
20120028849MICROWAVE ACCELERATED ASSAYS - The present invention provides for increasing fluorescence detection in surface assay systems while increasing kinetics of a bioreaction therein by providing low-power microwaves to irradiate metallic materials within the system in an amount sufficient to increase heat thereby affecting the kinetics of a bioreaction therein.02-02-2012
20120028847ASSEMBLIES FOR MULTIPLEX ASSAYS - Multiplex binding assay assemblies are disclosed. The assemblies include at least one assay bar that has a top side, a bottom side, and at least one well accessible from the top side of the assay bar, with each well including a side surface, a bottom surface, an open top end. Each well also includes at least one secondary container, with each secondary container including a capillary tube that (i) begins at a location within an interior volume of the well and (ii) ends at a location beneath the bottom side of the assay bar. The assemblies further include a guiding track, which includes a set of two rails, with each rail having its own separate groove. Such grooves are configured to run parallel to each other with a distance between such grooves, with a first groove configured to receive a protruding element (or an end) of a first side of the assay bar, and a second groove configured to receive a protruding element (or an end) of a second side of the assay bar. The set of two separate grooves are configured to allow the assay bar to glide along the grooves from one side to a second side of the guiding track.02-02-2012
20120028846GAS SENSOR INCORPORATING A POROUS FRAMEWORK - The disclosure provides sensor for gas sensing including CO02-02-2012
20120028845Sensor for Detecting Biological Agents in Fluid - Systems and apparatus are disclosed for detecting biological agents in fluids. Biosensor apparatus utilizes a sample chamber configured for receiving a fluid sample. Wells accessible from the sample chamber include electrodes deployed for receiving one or more electromagnetic signal from each of the wells. The electrodes are pre-provided with biomaterial deposits selected to attract particular biological agents of interest. An integrated circuit connected with electrodes facilitates electromagnetic signal acquisition and processing of parameters measurable at the well electrodes.02-02-2012
20120071364DETECTION OF NUCLEIC ACID SEQUENCE DIFFERENCES USING THE LIGASE DETECTION REACTION WITH ADDRESSABLE ARRAYS - The present invention describes a method for identifying one or more of a plurality of sequences differing by one or more single base changes, insertions, deletions, or translocations in a plurality of target nucleotide sequences. The method includes a ligation phase, a capture phase, and a detection phase. The ligation phase utilizes a ligation detection reaction between one oligonucleotide probe, which has a target sequence-specific portion and an addressable array-specific portion, and a second oligonucleotide probe, having a target sequence-specific portion and a detectable label. After the ligation phase, the capture phase is carried out by hybridizing the ligated oligonucleotide probes to a solid support with an array of immobilized capture oligonucleotides at least some of which are complementary to the addressable array-specific portion. Following completion of the capture phase, a detection phase is carried out to detect the labels of ligated oligonucleotide probes hybridized to the solid support.03-22-2012

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