Class / Patent application number | Description | Number of patent applications / Date published |
506037000 | Integrated apparatus specially adapted for both creating and screening a library | 30 |
20090253592 | METHOD AND APPARATUS FOR TREATING A BIOLOGICAL SAMPLE WITH A LIQUID REAGENT - A method and apparatus for thin film fluid processing of biological samples without rinsing between treatments is provided. An apparatus having a treatment zone for treating a biological sample with a liquid reagent, comprising first and second substrates having facing surfaces defining a space therebetween in which the biological sample may be treated with the liquid reagent, wherein the first substrate comprises a relatively fluid impermeable element while the second substrate comprises a relatively flexible gas permeable element. | 10-08-2009 |
20110124530 | PSEUDO-TISSUES AND USES THEREOF - The invention provides compositions and methods useful in the analysis of tissues and cells. More specifically, the invention provides compositions, referred to as “pseudo-tissue samples,” which comprise aggregated fixed cells embedded in an embedding medium. The invention also provides histological specimens comprising pseudo-tissues, as well as histological specimen-substrate compositions, such as microscope slides upon which pseudo-tissues and histological specimens prepared therefrom are placed. The histological specimen-substrate compositions may comprise arrays (or microarrays) of pseudo-tissues and/or histological specimens. The invention also provides methods for preparing pseudo-tissues, histological specimens, and histological specimen-substrate compositions containing the same. Also provided is a method for analyzing a tissue sample by comparing the subcellular features of a reference histological specimen to those found in a candidate histological specimen, such that one or more subcellular features shared by both the candidate and reference histological specimens may be identified. The subcellular features that may be identified include, e.g., DNA, RNA, proteins, enzymes and carbohydrates. | 05-26-2011 |
20110166044 | MICROFLUIDIC REACTION APPARATUS FOR HIGH THROUGHPUT SCREENING - An SBS-formatted microfluidic device where the geometry of the plate defines an array of interrogation areas, and where each interrogation area encompasses at least one reaction site. | 07-07-2011 |
20110177980 | MICROFLUIDIC CHIP-BASED DNA COMPUTER - The present invention relates to computer science, molecular biology and microfluidics technique which provides a DNA molecular computer based on microfluidic chip. The objective is to provide a DNA molecular computer which uses the microfluidic chip as a operation platform, mainly including: using DNA molecules as operation media, using the microfluidic chip as the operation platform of a DNA molecular operator; using DNA molecules as storage media, using the microfluidic chip as the operation platform of a DNA molecular storage; using a electronic computer and a detector as the kernel of a controller; said microfluidic chip includes a DNA molecular computation region and a DNA molecular storage region. The microfluidic chip consists of digestion, ligation, PCR amplification and chip electrophoresis unit connected by microchannels in turn, and carries out the liquid control through micropumps and microvalves. | 07-21-2011 |
20110218124 | ASSEMBLIES FOR MULTIPLEX BINDING ASSAYS - Assay plate assemblies are disclosed. The assemblies include an assay plate that has a top side, a bottom side, and at least one well accessible from the top side of the plate. The well includes a side surface and a bottom surface, with at least one secondary container protruding through the bottom surface and into an interior volume of the well. The assemblies further include a dispenser plate that is adapted to be positioned adjacent to the top side of the assay plate. The dispenser is further configured to provide one or more reagents to one or more secondary containers of at least one well of the assay plate. | 09-08-2011 |
20110251109 | Fluidic methods for devices for parallel chemical reactions - Fluidic methods and devices for conducting parallel chemical reactions are disclosed. The methods are based on the use of in situ photogenerated reagents such as photogenerated acids, photogenerated bases, or any other suitable chemical compounds that produce active reagents upon light radiation. The present invention describes devices and methods for performing a large number of parallel chemical reactions without the use of a large number of valves, pumps, and other complicated fluidic components. The present invention provides microfluidic devices that contain a plurality of microscopic vessels for carrying out discrete chemical reactions. Other applications may include the preparation of microarrays of DNA and RNA oligonucleotides, peptides, oligosaccharides, phospholipids and other biopolymers on a substrate surface for assessing gene sequence information, screening for biological and chemical activities, identifying intermolecular complex formations, and determining structural features of molecular complexes. | 10-13-2011 |
20110257048 | Reactor Array for Producing and Analyzing Products - The present invention relates to a reactor array for producing and/or analysing products, comprising a plurality of vessels in which products can be produced on a preparative or analytical scale. | 10-20-2011 |
20110312615 | MICROFLUIDIC DEVICE WITH PARALLEL NUCLEIC ACID AMPLIFICATION SECTION - A microfluidic device for amplifying nucleic acid sequences, the microfluidic device having an inlet for receiving a sample containing genetic material, a plurality of reagent reservoirs containing reagents for addition to the sample, a first nucleic acid amplification section for amplifying nucleic acid sequences in the genetic material, and, a second nucleic acid amplification section for amplifying nucleic acid sequences in the genetic material in parallel with the first nucleic acid amplification section. | 12-22-2011 |
20110312616 | TEST MODULE WITH PARALLEL DNA AND RNA AMPLIFICATION SECTIONS - A test module for amplifying DNA and RNA, the test module having an outer casing with receptacle for receiving a sample containing genetic material including DNA and RNA, a plurality of reagent reservoirs containing reagents for addition to the sample, a first nucleic acid amplification section for amplifying at least some of the genetic material, and, a second nucleic acid amplification section for amplifying at least some of the genetic material in parallel with the first nucleic acid amplification section. | 12-22-2011 |
20110312617 | MONOLITHIC MICROSYSTEMS TECHNOLOGY DEVICE FOR OLIGONUCLEOTIDE SPOTTING - A microsystems technology (MST) device for contactless spotting of oligonucleotide probes onto a surface, the probes having nucleic acid sequences that are complementary to target nucleic acid sequences to be identified in a biological sample, the MST device having a monolithic substrate having a reservoir side and an ejector side opposite the reservoir side, an array of reservoirs formed in the reservoir side, and, an array of ejectors formed on the ejector side, each of the ejectors being configured for fluid communication with a corresponding one of the reservoirs respectively, wherein, the ejectors are configured to eject droplets containing the oligonucleotide probes from the corresponding reservoir onto the surface. | 12-22-2011 |
20110312618 | OLIGONUCLEOTIDE SPOTTING DEVICE WITH HIGH SPOTTING RATE - An oligonucleotide spotting device for contactless spotting of probes onto a surface, the probes having nucleic acid sequences that are complementary to target nucleic acid sequences to be identified in a biological sample, the oligonucleotide spotting device having an array of ejectors, each having an actuator for ejecting droplets of liquid containing the probes, CMOS circuitry for providing each of the actuators with a drive pulse for droplet ejection, wherein during use, the array of ejectors spot the probes onto the surface at a rate greater than 100 probe spots per second. | 12-22-2011 |
20110312619 | DEVICE FOR HIGH-DENSITY DEPOSITION OF BIOCHEMICALS - A biochemical deposition device for contactless deposition of biochemicals on a surface, the biochemical deposition device having a supporting substrate, an array of reservoirs on one side of the substrate, the reservoirs being configured for containing a plurality of biochemicals, and, an array of ejectors on the other side of the supporting substrate, the ejectors being in fluid communication with the reservoirs, and configured to eject droplets containing the biochemicals onto the surface with a density greater than 1 droplet per square millimeter. | 12-22-2011 |
20110312620 | SYSTEM FOR VARIABLE MICROARRAY SPOTTING AND GENETIC ANALYSIS - A system for microarray spotting and genetic analysis, the system having containers with probes for hybridization with different target nucleic acid sequences, an integrated circuit secured to each of the containers respectively, each of the integrated circuits have a container digital memory storing probe specification data related to probes in that container, a microfluidic device for supporting an array of probes selected from the containers, the selected probes corresponding to a desired genetic test assay, the microfluidic device having a device digital memory, an oligonucleotide spotting robot for spotting the selected probes onto the microfluidic device to form the array of probes, the oligonucleotide spotting robot having a control microprocessor for downloading the specification data to the device digital memory, and, a device reader for accessing the specification data from the device digital memory in order to analyze hybridization data from the microfluidic device. | 12-22-2011 |
20110312621 | APPARATUS FOR DISPENSING REAGENTS AND LOADING OLIGONUCLEOTIDE SPOTTING DEVICES - An apparatus for dispensing reagents and loading oligonucleotide spotting devices, the apparatus having a plurality of reagent vials, each with a droplet dispenser, a plurality of oligonucleotide vials, each with a droplet dispenser, a mounting surface for detachably mounting a microfluidic device for movement relative to the reagent vials, and detachably mounting an oligonucleotide spotting device, and, a control processor for operative control of the reagent vials and oligonucleotide vials and movement of the mounting surface relative to the reagent vials and oligonucleotide vials, wherein, the control processor is configured to activate any of the droplet dispensers, move the microfluidic device into registration with the reagent vials and move the oligonucleotide spotting device into registration with the oligonucleotide vials. | 12-22-2011 |
20120028844 | REAGENT DISPENSERS AND STACKABLE BARS FOR MULTIPLEX BINDING ASSAYS - Multiplex binding assay assemblies are disclosed. The assemblies generally include at least one assay bar that includes a top side, a bottom side, and at least one well accessible from the top side of the assay bar. Each well includes a side surface, a bottom surface, an open top end, and at least one secondary container, with each secondary container including a capillary tube that (i) begins at a location within an interior volume of the well and (ii) ends at a location beneath the bottom surface of the assay bar. The assemblies further include a dispenser bar that is adapted to be positioned adjacent to the top side of the assay bar, which includes one or more reservoirs that are configured to provide one or more reagents to the at least one secondary container located in each well of the assay bar. | 02-02-2012 |
20120252703 | METHOD AND SYSTEM FOR CAPTURE AND USE OF INTACT VESICLES ON ELECTRODEPOSITED HYDROPHOBICALLY MODIFIED BIOPOLYMER FILMS - A biosensor comprising an electrically conductive substrate coated with a modified chitosan biopolymer that has been electrodeposited on the substrate, wherein said modified chitosan biopolymer comprises at least one vesicle binding molecule. The biosensor is manufactured by a method where a modified chitosan biopolymer is electrodeposited on a substrate. The method is also used to manufacture a modified chitosan biopolymer film by electrodeposition of the chitosan on the substrate and later removing the film from the substrate after electrodeposition. The resulting film can be used in bandages to treat various types of wounds. The biosensor can also be used to detect various analytes in samples. | 10-04-2012 |
20130090268 | VALVED, MICROWELL CELL-CULTURE DEVICE AND METHOD - A valved microfluidics device, microfluidics cell-culture device and system incorporating the devices are disclosed. The valved microfluidics device includes a substrate, a microchannel through which liquid can be moved from one station to another within the device, and a pneumatic microvalve adapted to be switched between open and closed states to control the flow of fluid through a microchannel. The microvalve is formed of three flexible membranes, one of which is responsive to pneumatic pressure applied to the valve and the other two of which deform to produce a more sealable channel cross-section. The cell culture device provides valving to allow controlled loading of cells into the individual well of the device, and exchange of cell-culture components in the wells. | 04-11-2013 |
20130150266 | SYSTEMS AND METHODS FOR HIGH SPEED ARRAY PRINTING AND HYBRIDIZATION - Novel and improved systems and methods for high speed arraying, hybridization, quantitative development and/or assaying are provided. Some embodiments provide a web based arraying format. Some other embodiments provide a sheet based arraying format. Some embodiments use a drop on drop assaying or hybridization mode. In some embodiments, a substantially inert substrate is utilized. In some other embodiments, an interactive substrate is utilized. | 06-13-2013 |
20130190212 | CELL CAPTURE SYSTEM AND METHOD OF USE - A cell capture system including an array, an inlet manifold, and an outlet manifold. The array includes a plurality of parallel pores, each pore including a chamber and a pore channel, an inlet channel fluidly connected to the chambers of the pores; an outlet channel fluidly connected to the pore channels of the pores. The inlet manifold is fluidly connected to the inlet channel, and the outlet channel is fluidly connected to the outlet channel. A cell removal tool is also disclosed, wherein the cell removal tool is configured to remove a captured cell from a pore chamber. | 07-25-2013 |
20130303408 | ASSEMBLIES FOR MULTIPLEX BINDING ASSAYS - Assay plate assemblies are disclosed. The assemblies include an assay plate that has a top side, a bottom side, and at least one well accessible from the top side of the plate. The well includes a side surface and a bottom surface, with at least one secondary container protruding through the bottom surface and into an interior volume of the well. The assemblies further include a dispenser plate that is adapted to be positioned adjacent to the top side of the assay plate. The dispenser is further configured to provide one or more reagents to one or more secondary containers of at least one well of the assay plate. | 11-14-2013 |
20130345096 | Microfluidic Chip Automatic System With Optical Platform - A microfluidic chip automatic system includes a microfluidic chip platform and an optical platform. The microfluidic chip platform includes a microfluidic chip, a fluid source, a gas source, and a controller. A time sequence of charging a high pressure gas from the gas source into the microfluidic chip and discharging the high pressure gas from the microfluidic chip is controlled by the controller through plural solenoid valves. The optical platform includes a light source, plural lenses, a digital micromirror device, a grating device and a reflective mirror. A light beam provided by the light source is guided to the microfluidic chip. The digital micromirror device includes plural micromirrors. The optical switching states of the micromirrors are controlled by a computer, so that a position of the microfluidic chip to carry out a photochemical reaction is correspondingly controlled. | 12-26-2013 |
20140128293 | DEVICE TO DETECT ANALYTES IN A BIOLOGICAL SAMPLE - Device to detect at least an analyte, comprising a transparent substrate ( | 05-08-2014 |
20140323358 | Vacuum Assist for a Microplate - A vacuum assist apparatus can comprise a microplate. The microplate can comprise a first surface and an opposing second surface. A plurality of wells can be formed in the first surface of the microplate. Each of the plurality of wells can be sized to receive an assay therein. A support base can comprise a fluid passage. The microplate can be positioned adjacent and in contact with the support base. A pressure device, in fluid communication with the fluid passage, can exert a vacuum within the fluid passage to actively retain the microplate in the contact with the support base. | 10-30-2014 |
20150099673 | DIGITAL COUNTING OF INDIVIDUAL MOLECULES BY STOCHASTIC ATTACHMENT OF DIVERSE LABELS - Compositions, methods and kits are disclosed for high-sensitivity single molecule digital counting by the stochastic labeling of a collection of identical molecules by attachment of a diverse set of labels. Each copy of a molecule randomly chooses from a non-depleting reservoir of diverse labels. Detection may be by a variety of methods including hybridization based or sequencing. Molecules that would otherwise be identical in information content can be labeled to create a separately detectable product that is unique or approximately unique in a collection. This stochastic transformation relaxes the problem of counting molecules from one of locating and identifying identical molecules to a series of binary digital questions detecting whether preprogrammed labels are present. The methods may be used, for example, to estimate the number of separate molecules of a given type or types within a sample. | 04-09-2015 |
20150119296 | SYSTEMS AND METHODS FOR HIGH SPEED ARRAY PRINTING AND HYBRIDIZATION - Novel and improved systems and methods for high speed arraying, hybridization, quantitative development and/or assaying are provided. Some embodiments provide a web based arraying format. Some other embodiments provide a sheet based arraying format. Some embodiments use a drop on drop assaying or hybridization mode. In some embodiments, a substantially inert substrate is utilized. In some other embodiments, an interactive substrate is utilized. | 04-30-2015 |
20160053314 | Microfluidic Devices - Methods and devices for the interfacing of microchips to various types of modules are disclosed. The technology disclosed can be used as sample preparation and analysis systems for various applications, such as DNA sequencing and genotyping, proteomics, pathogen detection, diagnostics and biodefense. | 02-25-2016 |
20160061829 | SYSTEMS, DEVICES, AND METHODS FOR AGGLUTINATION ASSAYS USING SEDIMENTATION - Embodiments of the present invention include methods for conducting agglutination assays using sedimentation. Aggregates may be exposed to sedimentation forces and travel through a density medium to a detection area. Microfluidic devices, such as microfluidic disks, are described for conducting the agglutination assays, as are systems for conducting the assays. | 03-03-2016 |
20160074828 | INTEGRATED CIRCUIT HAVING TEMPERATURE-SENSING DEVICE - An integrated circuit includes a plurality of sensing pixels. Each sensing pixel of the plurality of sensing pixels includes a sensing film portion, a potential-sensing device configured to generate a first signal responsive to an electrical characteristic of the sensing film portion, a temperature-sensing device configured to generate a second signal responsive to a temperature of the sensing film portion, and one or more heating elements configured to adjust the temperature of the sensing film portion. | 03-17-2016 |
20160160211 | TWO DIMENSIONAL CAPILLARY ELECTROPHORESIS APPARATUS - The present disclosure describes an apparatus for identifying a polynucleotide capable of binding a target. The apparatus comprises a first, second, and third high voltage power supply; a first, second, and third capillary tube; a first, second, and third buffer reservoir; a fraction collector, and at least one collection vessel. | 06-09-2016 |
20160375441 | APPARATUS AND METHOD FOR NUCLEIC ACID AMPLIFICATION - The present invention provides apparatus ( | 12-29-2016 |