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506 - Combinatorial chemistry technology: method, library, apparatus

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Class / Patent application numberDescriptionNumber of patent applications / Date published
506030000 Solid-phase synthesis (i.e., wherein one or more library building blocks are bound to a solid support during library creation) or particular method of cleavage from the solid support used 125
506026000 Biochemical method (e.g., using an enzyme or whole viable micro-organism, etc.) 125
506027000 Liquid-phase synthesis (i.e., wherein all library building blocks are in liquid phase or in solution during library creation) or particular method of cleavage from the liquid support used 25
506024000 In silico or mathematical conception of a library 17
506025000 Using a dynamic combinatorial chemistry technique 2
20110281773ADVANCED MIXING SYSTEM FOR INTEGRATED TOOL HAVING SITE-ISOLATED REACTORS - An integrated processing tool is described comprising a full-wafer processing module and a combinatorial processing module. Chemicals for use in the combinatorial processing module are fed from a delivery system including a set of first manifolds. An output of each first manifold is coupled to at least one mixing vessel. An output of each mixing vessel feeds more than one of a set of second manifolds. An output of each set of second manifolds feeds one of multiple site-isolated reactors of the combinatorial processing module.11-17-2011
20120190586Synthetic Receptors for Identification of Protein Posttranslation Modifications - A method of making a synthetic organic receptor that specifically binds to a modified amino acid is carried out by: reacting a plurality of monomers in a dynamic combinatorial library in the presence of a protein or peptide to form a reaction product, the protein or peptide comprising a modified nucleic acid, with the reacting step carried out under conditions in which at least one oligomer that specifically binds to the modified amino acid is selectively amplified in the reaction product; and then isolating or identifying from the reaction product at least one oligomer that specifically binds to the modified amino acid.07-26-2012
20090247426FOCUSED LIBRARY GENERATION - The present invention relates generally to in vitro methods for generating mutant nucleic acid and polypeptide libraries. In particular, the present invention provides methods and compositions for mutagenesis and recombination of polynucleotide sequences in amplification methods that utilize primer oligonucleotides, and for expressing the resultant nucleic acid libraries to generate polypeptide libraries.10-01-2009
20090305907Method for Creating Distinct Nitrocellulose-based Pads on a Substrate - A method for defining arrays of specific areas of porous nitrocellulose based pads on a substrate directly without the need for removal of nitrocellulose in unwanted regions; covering said substrate with a removable frame constructed out of 3-4 mm silicone rubber; using a dispensing station, consisting of a XYZ robot, multi-channel syringe pump, and dispensing head comprised of an array of flat hypodermic syringe needles, to spread the nitrocellulose-based solution in a programmed fashion onto said substrate covered by said removable frame.12-10-2009
20090298715Process Vessel with Integral Evaporator - A process vessel containing both an evaporation zone for evaporating a liquid feed and a treatment zone for treating the resulting vapor comprises an injector having an orifice, the orifice being in the evaporation zone, at least one evaporation surface for evaporating feed and generating vapor, the evaporation surface being located in the evaporation zone, wherein the injector orifice and the evaporation surface are positioned to prevent the formation of a drop at the orifice, a treatment zone for treating the vapor and at least one heater associated with at least a portion of the process vessel.12-03-2009
20120270753METERING DEVICE AND METHOD FOR OPERATING SAME - A metering device, a metering element, and a method for operating same, the metering element having a storage container open on one side for receiving the substances to be metered and a plunger which is axially movable and reversibly seals the opening of the storage container and which preferably has at least one centrally located metering opening for metering the substances provided in the storage container, the plunger including a separation device for particles.10-25-2012
20110294703Stamping Apparatus For Biochips and Method For Operation Thereof - Disclosed herein is a stamping apparatus for biochips and a method of operating the stamping apparatus. The apparatus includes a table, a first chip table, a second chip table, a stamping unit and a control unit. The first chip table is provided on the table. A first biochip is seated onto the first ship table. A second biochip is seated onto the second chip table. The stamping unit is mounted to the table and operates the second chip table such that a surface of a junction of the second biochip seated on the second chip table is joined to a surface of a junction of the first biochip seated on the first chip table. The control unit controls operation of the first chip table or the second chip table.12-01-2011
20090170726PHOTO OR ELECTRON BEAM CURABLE COMPOSITIONS - A curable composition and a process for using the curable composition within a grating-coupled waveguide (GCW) sensor are disclosed. The composition can be used for facile replication of optical components, specifically those used in a label-independent detection system where operation of the waveguide is dependent on the detailed formation of micro and nano size patterns. The photo or electron beam curable composition has low viscosity (≦500 cPs) and cures to an optically clear material with high glass transition temperature (≦70° C.), low shrinkage on cure, low outgassing, and low extractables.07-02-2009
20100009870BIOMOLECULE-IMMOBILIZED PLATE AND METHOD FOR FABRICATING BIOMOLECULE-IMMOBILIZED PLATE - There is provided a biomolecule-immobilized plate having a flat part, at least a surface of the flat part comprising a polymer material, wherein the flat part has an arithmetic average roughness of 0.1 nm˜5 nm, and a portion of the flat part has functional groups. Further, the biomolecule-immobilized plate is fabricated by irradiating the flat part of the plate surface which comprises the polymer material, with an ultraviolet ray under ozone atmosphere to produce functional groups having bonding ability to the biomolecules on a portion of the flat part. Thereby, it is possible to provide a biomolecule-immobilized plate having a surface of a high degree of smoothness on which functional groups are produced, a biomolecule-immobilized plate on which biomolecules are immobilized via functional groups, and methods for fabricating these biomolecule-immobilized plates easily and inexpensively.01-14-2010
20080207467Methods for the design of libraries of protein variants - The present invention is directed to designing a collection of protein variants.08-28-2008
20080280783Baculovirus-Based Gene Libraries - A nucleotide molecule comprising a selectable gene flanked by anL1 and anL2 attachment sites of a bacteriophage and additionally comprising an origin of replication. This can be used to create a baculovirus-based gene library.11-13-2008
20080234141GENERATION OF COMPOUND LIBRARIES UTILIZING MOLECULAR IMPRINTS INCLUDING A DOUBLE OR ANTI-IDIOTYPIC APPROACH - The present invention relates to a method of producing new chemical entities comprising the steps of: (i) taking a chemical entity as the template to prepare a molecularly imprinted polymer (MIP), (ii) removing the template from the MIP, (iii) using the specific binding sites of the MIP to direct, or facilitate, the syntheses of new chemical entities for the generation of compound libraries using molecularly imprinted polymers, and to a use of such compound libraries.09-25-2008
20090093378Method for sequencing a polynucleotide template - The invention relates to methods for pairwise sequencing of a double-stranded polynucleotide template, which methods result in the sequential determination of nucleotide sequences in two distinct and separate regions of the polynucleotide template.04-09-2009
20100184628BIS-SULFHYDRYL MACROCYCLIZATION SYSTEMS - The present invention provides novel peptidomimetic macrocycles and methods for their preparation and use, as well as amino acid analogs and macrocycle-forming linkers, and kits useful in their production.07-22-2010
20110124527UNIVERSAL FIBRONECTIN TYPE III BINDING-DOMAIN LIBRARIES - Walk-through mutagenesis and natural-variant combinatorial fibronectin Type III (FN3) polypeptide libraries are described, along with their method of construction and use. Also disclosed are a number of high binding affinity polypeptides selected by screening the libraries against a variety of selected antigens.05-26-2011
20100184627OLIGONUCLEOTIDE MEDIATED NUCLEIC ACID RECOMBINATION - Methods of recombining nucleic acids, including homologous nucleic acids, are provided. Families of gene shuffling oligonucleotides and their use in recombination procedures, as well as polymerase and ligase mediated recombination methods are also provided.07-22-2010
20110086780SYSTEM FOR FORMING AN ARRAY OF EMULSIONS - A system, including method and apparatus, for forming an array of emulsions. The system may include a plate providing an array of emulsion production units each configured to produce a separate emulsion and each including a set of wells interconnected by channels that intersect to form a site of droplet generation. Each set of wells, in turn, may include (1) at least one first input well to receive a continuous phase, (2) a second input well to receive a dispersed phase, and (3) an output well configured to receive from the site of droplet generation an emulsion of droplets of the dispersed phase disposed in the continuous phase.04-14-2011
20100279898NORMALIZED NUCLEIC ACID LIBRARIES AND METHODS OF PRODUCTION THEREOF - The present invention relates generally to methods for producing normalized nucleic acid libraries in which each member of the library can be isolated with approximately equivalent probability. In particular, the present methods comprise subtractive hybridization of a nucleic acid library with haptenylated (e.g., biotinylated, avidinated or streptavidinated) nucleic acid molecules that are complementary to one or more of the nucleic acid molecules of the library, such that the variation in the abundances of the individual nucleic acid molecules in the library is reduced. The invention also relates to production of normalized nucleic acid libraries (particularly cDNA libraries) in which contaminating nucleic acid molecules have been reduced or eliminated, and to normalized nucleic acid libraries produced by such methods.11-04-2010
20120202715TISSUE DISSAGGREGATOR DEVICE AND METHODS OF USING THE SAME - The tissue disaggregator device includes a base having a multiple well array. Each of the wells includes a screen embedded into bottom portion of the well. The device removably connects with standardized plate and allows for multiple fold increase in tissue sample preparation.08-09-2012
20120277123APPARATUS AND METHOD FOR MANUFACTURING MICROARRAY BIOCHIP - An apparatus of manufacturing a microarray biochip including a spinning platen, at least one carrier and at least one substrate is provided. The carrier is disposed on the spinning platen and includes at least one micro-channel having an input terminal and an output terminal. The substrate is attached on the output terminal of the micro-channel of the carrier. A method of manufacturing a microarray biochip with said apparatus is also provided. A sample is injected into the micro-channel through the input or the output terminal. The spinning platen is powered-on to provide a centrifugal force to the carrier, such that the sample is flowed toward the output terminal from the input terminal, and then is immobilized on the surface of the substrate.11-01-2012
20110053805THERMOCHEMICAL NANOLITHOGRAPHY COMPONENTS, SYSTEMS, AND METHODS - Improved nanolithography components, systems, and methods are described herein. The systems and methods generally employ a resistively heated atomic force microscope tip to thermally induce a chemical change in a surface. In addition, certain polymeric compositions are also disclosed.03-03-2011
20110263461METHODS AND DEVICES FOR COLLECTING SAMPLES IN A HIGH THROUGHPUT FORMAT - The present invention is directed methods for collecting and storing samples compatible for high throughput automation. The present invention is also directed to a device comprising: (a) a plate containing multiple wells, and (b) multiple rubber covers; wherein each rubber cover is (i) an integral part of the device, (ii) is on top of each well and individually seal each well, and (iii) has a pierceable area in the center of the cover. The device is suitable for collecting, storing, transporting, and tracking samples compatible for high throughput downstream automated processing.10-27-2011
20110136696CONTINUOUS POLYMER SYNTHESIZER - Described is a system and method for synthesizing polymeric molecules such as oligonucleotides and polypeptides. The system is capable of continuously synthesizing molecules by providing an array of reaction sites and an array of stations for carrying out synthetic manipulations. The reaction sites in the former array can be placed in a fixed order and at fixed intervals relative to each other. Similarly, the stations can be placed in a fixed order and at fixed intervals relative to each other. The two arrays can be moved relative to each other such that the stations carry out desired steps of a reaction scheme at each reaction site. The relative locations of the stations and the schedule for the relative movement can correlate with the order and duration of reaction steps in the reaction scheme such that once a reaction site has completed a cycle of interacting with the full array of stations then the reaction scheme is complete.06-09-2011
20120302466T CELL RECEPTOR-DEFICIENT T CELL COMPOSITIONS - The invention is directed to modified T cells, methods of making and using isolated, modified T cells, and methods of using these isolated, modified T cells to address diseases and disorders. In one embodiment, this invention broadly relates to TCR-deficient T cells, isolated populations thereof, and compositions comprising the same. In another embodiment of the invention, these TCR-deficient T cells are designed to express a functional non-TCR receptor. The invention also pertains to methods of making said TCR-deficient T cells, and methods of reducing or ameliorating, or preventing or treating, diseases and disorders using said TCR-deficient T cells, populations thereof, or compositions comprising the same.11-29-2012
20100022415ACTIVE CARRIER, ITS PRODUCTION AND ITS USE - Active carrier that consists of a carrier base (01-28-2010
20100227778Diagnosis and Treatment of Noonan Syndrome and Neoplastic Disorders - Methods and compositions for diagnosing and treating Noonan syndrome and neoplastic disorders are provided herein.09-09-2010
20110118148NUCLEAR MAGNETIC RESONANCE ASSEMBLY OF CHEMICAL ENTITIES USING ADVANCED ANTENNA PROBES - The invention provides a method for identifying a ligand that binds to a macromolecular target. The methods involve (a) attaching an antenna moiety to a first ligand, wherein the ligand binds specifically to a macromolecular target; (b) providing a sample comprising the macromolecular target, the first ligand and a candidate second ligand under conditions wherein the first ligand and the macromolecular target form a bound complex; (c) detecting a subset of magnetization transfer signals between the antenna moiety of the first ligand and the second candidate ligand, wherein the signals are obtained from an isotope edited NOESY spectrum of the sample; thereby determining that the two ligands are proximal in a bound complex, and identifying a second ligand that binds to the macromolecular target.05-19-2011
20120040868Combinatorial Synthesis of Diamond - Disclosed is a combinatorial synthesis of Diamond wherein a first reactive species is produced by catalytic treatment of Acetylene, a second reactive species is produced by decomposition of a hydrocarbon source having a low Hydrogen-to-Carbon ratio using a high energy discharge, and the two reactive species so obtained are combined in the vapor phase to yield Diamond without the need of post-treatments. The reaction is efficient and affords Diamond under mild conditions with high purity such that it may be useful for producing Diamond for semiconductor and microelectronics applications.02-16-2012
20120129730GENERATION OF COMPOUND LIBRARIES UTILIZING MOLECULAR IMPRINTS INCLUDING A DOUBLE OR ANTI-IDIOTYPIC APPROACH - The present invention relates to a method of producing new chemical entities comprising the steps of: (i) taking a chemical entity as the template to prepare a molecularly imprinted polymer (MIP), (ii) removing the template from the MIP, (iii) using the specific binding sites of the MIP to direct, or facilitate, the syntheses of new chemical entities for the generation of compound libraries using molecularly imprinted polymers, and to a use of such compound libraries.05-24-2012
20110009295SYSTEM, HEATING BLOCK AND METHOD - The present invention provides a system, comprising at least one reactor array, comprising at least two reactor vessels (01-13-2011
20110046017MOLD OF RECIPIENT BLOCK AND USAGE THEREOF - Disclosed are a mold for the preparation of recipient blocks, having a certain space at the top and containing multiple sample-receiving holes in the bottom thereof and a method for preparing a tissue microarray block, comprising: (1) arraying samples in the sample-receiving holes in the mold for the preparation of recipient blocks; (2) placing the mold for the preparation of recipient blocks in a base mold and pushing the samples toward the bottom of the base mold; (3) filling the base mold with a liquid base material for the recipient block and incubating the liquid base material at a predetermined temperature for a predetermined time period; and (4) separating the tissue microarray block from the mold for the preparation of recipient blocks, said tissue microarray block being formed as the liquid base material is solidified so that the samples are embedded in a microarray pattern within the solidified material.02-24-2011
20080234140Method and Device for Applying a Plurality of Microdroplets on a Substrate - The invention relates to a device for applying a plurality of microdroplets to a substrate (09-25-2008
20110312613CARRIERS FOR COMBINATORIAL COMPOUND LIBRARIES - A carrier pre-encoded with information sufficient to distinguish it from a heterogeneous population of carriers is disclosed on which a compound can be synthesised. The carrier has two attributes integrally associated therewith, which attributes are detectable and/or quantifiable during synthesis of the compound and which define a code identifying the carrier before, during and after said synthesis, with the proviso that one of said attributes is other than shape, or surface deformation(s) of the carrier. The invention also encompasses a plurality of carriers that are pre-encoded as above and a method of synthesising and deconvoluting a combinatorial library using such carriers.12-22-2011


Patent applications in all subclasses METHOD OF CREATING A LIBRARY (E.G., COMBINATORIAL SYNTHESIS, ETC.)