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Library containing only organic compounds

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506 - Combinatorial chemistry technology: method, library, apparatus


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Class / Patent application numberDescriptionNumber of patent applications / Date published
506016000 Nucleotides or polynucleotides, or derivatives thereof 480
506018000 Peptides or polypeptides, or derivatives thereof 92
506020000 Macromolecular compounds (e.g., synthetic resin, rubber, etc.) 9
506019000 Saccharides or polysaccharides, or derivatives thereof 9
506021000 Metal-containing organic compounds 2
20120149601Methods and systems for detection of nitroalkyl, nitroamine, nitroaromatic and peroxide compounds - Methods, systems and related apparatus for fluorescence-based detection of various nitro and peroxide compounds.06-14-2012
20130210679METAL NANOPARTICLE ORGANIC COMPOSITE FILM AND METHOD FOR ITS PREPARATION - The present invention relates to method for preparing a metal nanoparticle organic composite film, preferably a metal nanoparticle organic composite film of a chemical sensing device, to a metal nanoparticle organic composite film obtained by said method, and to a chemical sensing device comprising a metal nanoparticle organic composite film or an array of different metal nanoparticle organic composite films obtained by said method.08-15-2013
20120184462LATERAL FLOW ASSAYS USING TWO DIMENSIONAL FEATURES - The present invention relates to novel lateral flow devices using two dimensional features, preferably, uniform two dimensional test and control features, and the methods for detecting an analyte using the lateral flow devices, and processes for making the lateral flow devices.07-19-2012
20100113305OXAZOLE AND THIAZOLE COMBINATORIAL LIBRARIES - This invention provides a novel method for synthesizing an ensemble of peptides that allows for the generation of an unlimited number of antibiotic compounds. More specifically, the method comprises utilizes synthetic heterocyclic amino acids containing thaizole and/or oxazole as building blocks in a solid phase combinatorial synthesis to yield natural and unnatural antibiotic compounds.05-06-2010
20120165227COMPOUNDS AND METHODS FOR DETECTION AND QUANTIFICATION OF CARBOXYLIC ACIDS - The present disclosure includes compounds of Formula I: wherein R06-28-2012
20090325816Massively parallel lithography with two-dimensional pen arrays - Massive parallel printing of structures and nanostructures, including lipids, at high speed with high resolution and high quality using two dimensional arrays comprising cantilevers and tip-based transfer of material to a surface. The array is designed so only tips touch the surface. This can be accomplished by long tips and bent cantilevers and alignment. An article comprising: a two-dimensional array of a plurality of cantilevers, wherein the array comprises a plurality of base rows, each base row comprising a plurality of cantilevers, wherein each of the cantilevers comprise tips at the cantilever end away from the base, wherein the number of cantilevers is greater than 250, and wherein the tips have an apex height relative to the cantilever of at least four microns, and a support for the array. Combinatorial arrays and bioarrays can be prepared. The arrays can be manufactured by micromachining methods.12-31-2009
20090023601GEL HAVING BIOSUBSTANCE FIXED THERETO AND MICROARRAY UTILIZING THE GEL - The present invention provides a biological substance-immobilized gel which comprises a gel containing 2%-7% by mass of N,N-dimethylacrylamide and a biological substance immobilized on and/or in the gel.01-22-2009
20110230371Chemical Arrays and Methods of Using the Same - Methods and compositions for generating mixtures of product molecules from an initial chemical array are provided. In the subject methods, a chemical array of surface immobilized first moieties is subjected to cleavage conditions such that a composition of solution phase first moieties is produced. The resultant composition of solution phase first moieties is then contacted with one or more reactants to produce a mixture of product molecules that are different from the first moieties. Also provided are the arrays employed in the subject methods and kits for practicing the subject methods.09-22-2011
20110130305Novel dyes and compositions, and processes for using same in analysis of protein aggregation and other applications - Provided are dyes and compositions which are useful in a number of applications, such as the detection and monitoring protein aggregation, kinetic studies of protein aggregation, neurofibrillary plaques analysis, evaluation of protein formulation stability, protein thermal stability shift assay and analysis of molecular chaperone activity. These dyes and compositions are also useful as probes in nucleic acid and protein detection.06-02-2011
20100210476Pyrrolo[2,3-b]Pyridine Derivatives Active as Kinase Inhibitors and Pharmaceutical Compositions Comprising Them - Compounds which are pyrrolo[2,3-b]pyridine derivatives or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders; also disclosed is a process under SPS conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.08-19-2010
20090105091Modified Amino Acids - The present invention provides a compound of the general formula (I), wherein X is the connection between the CO-hydrazine and the NR04-23-2009
20110263457Multiplex Cellular Assays Using Detectable Cell Barcodes - We describe herein a cell-based multiplexing technique called detectable cell barcoding (DCB). In DCB, each individual sample is labeled with a different DCB signature that distinguishes each sample by one or both of detected intensity or type of detection characteristic. The samples are then combined and analyzed for a detectable characteristic of interest (e.g., presence of an analyte). By employing multiple distinct DCB labels at varying concentrations, one can perform multiplex analyses on up to hundreds or thousands (or more) of cell samples in a single reaction tube. DCB reduces reagent consumption by factors of 100-fold or more, significantly reduces data acquisition times and allows for stringent control sample analysis.10-27-2011
20090005265METHOD OF ISOLATING NUCLEIC ACID USING MATERIAL POSITIVELY CHARGED AT FIRST PH AND CONTAINING AMINO GROUP AND CARBOXYL GROUP - A method of isolating nucleic acid from a sample containing nucleic acid is provided. The method includes contacting the sample with a bifunctional material that contains an amino group and a carboxyl group and is positively charged at a first pH to allow binding of the nucleic acid to the bifunctional material; and extracting the nucleic acid at a second pH higher than the first pH from the complex.01-01-2009
20090186777BIOCHIP HAVING INCREASED PROBE DENSITY - A biochip can include a substrate having surface features of protrusions or recesses and probes coupled to each of the surface features. A biochip can include a substrate having recess regions and probes coupled to each of the recess regions, wherein a surface of each of the recess regions has convexes and concaves. A biochip can include a substrate having recess regions, immobilization layers conformally formed in the recess regions, and probes coupled onto each of the immobilization layers. The biochip can be divided into probe cell regions to which the probes are coupled, wherein the recess regions are formed in the probe cell regions, and non-probe cell regions, wherein a surface of each of the non-probe cell regions can include an exposed surface of the substrate.07-23-2009
20090048123Reagentless and Reusable Biosensors with Tunable Differential Binding Affinities and Methods of Making - The biosensor comprises a modular biorecognition element and a modular flexible arm element. The biorecognition element and the flexible arm element are each labeled with a signaling element. The flexible arm contains an analog of an analyte of interest that binds with the biorecognition element, bringing the two signaling elements in close proximity, which establishes a baseline fluorescence resonance energy transfer (FRET). When an analyte of interest is provided to the biosensor, the analyte will displace the analyte analog, and with it, the signaling module of the modular flexible arm, causing a measurable change in the FRET signal in a analyte concentration dependent manner. The modularity of different portions of the biosensor allows functional flexibility. The biosensor operates without additional development reagents, requiring only the presence of analyte or target for function.02-19-2009
20090264315DIPEPTIDE MIMICS, LIBRARIES COMBINING TWO DIPEPTIDE MIMICS WITH A THIRD GROUP, AND METHODS FOR PRODUCTION THEREOF - Monovalent compounds having moieties comprising at least one amino acid side chain are bound to a core molecule, which also comprises a nucleophilic moiety bound to said core molecule. Monovalent compounds also comprise a macrocyclic ring, a nucleophilic moiety, and a spacer group. Monovalent compounds may be combined into bivalent and trivalent compounds, some of which may have a labeling tag. Methods of production of bivalent compounds and contemplated uses thereof are disclosed.10-22-2009
20090264316Ultraviolet/Ozone Patterned Organosilane Surfaces - UV/ozone treatment can be used to alter the hydrophobicity of organosilane coated surfaces. Methods are contemplated for producing micropatterned surfaces by coating a surface with an organosilane to produce an organosilane surface; and exposing the organosilane surface to ultraviolet light in the presence of oxygen, wherein the micropatterned organosilane surface is produced without the use of photoresist. Methods for producing substrate-micropatterned surfaces further are also contemplated. Suitable substrates include nucleotides, proteins, carbohydrates, and cells. The organosilane coated devices of the present invention may be used in, for example, arrays.10-22-2009
20090163380ANALYTE FOCUSING BIOCHIPS FOR AFFINITY MASS SPECTROMETRY - A novel affinity capture surface, as well as methods of using and making the affinity capture surface and sample presentation devices or biochips comprising the affinity capture surface, are disclosed. The affinity capture surface comprising a substrate surface having adjacent first and second affinity capture zones, wherein the first affinity capture zone comprises a first binary self-assembled monolayer comprising a plurality of affinity capture monomers and hydrophilic-terminated monomers associated with the substrate surface and the second affinity capture zone comprises a second binary self-assembled monolayer comprising a plurality of affinity capture monomers and hydrophobic-terminated monomers associated with the substrate surface, and wherein the affinity capture monomers are capable of selectively retaining an analyte and are cleavable to release terminal portions of the affinity capture monomers and the analyte, thereby generating a hydrophilic surface in the first affinity capture zone and a hydrophobic surface in the second affinity capture zone.06-25-2009
20080261831Ligands and libraries of ligands - The invention relates to variants of Target Biological Molecules (TBMs), such as proteins, peptides and other amino acid sequences that are modified to include cysteine residues at predetermined positions within the TBM. The position of amino acid residues within the TBM that are modified to be cysteine residues is selected for its proximity to ligand binding sites within the TBM. Once an amino acid residue, or the DNA encoding the residue, is modified to cysteine, the TBM linked to potential binding ligands by forming a covalent bond through the cysteine thiol (—SH) reactive group of the variant.10-23-2008
20120077711Novel Ligands and Libraries of Ligands - The present invention provides compounds and libraries of compounds having formula (I):03-29-2012
20080318806DEVICE FOR CHEMICAL AND BIOCHEMICAL REACTIONS USING PHOTO-GENERATED REAGENTS - This invention provides method and apparatus for performing chemical and biochemical reactions in solution using in situ generated photo-products as reagent or co-reagent. In particular, the present invention provides methods and devices for generating a photogenerated reaction in solution on a substrate comprising generating a light beam using an optical device system comprising a light source and a computer-controlled spatial optical modulator comprising a digital micromirror device and using the spatial optical modulator to direct light to fluidly isolated reaction sites under conditions such that a photogenerated reaction takes place. The method and apparatus of the present invention have applications in parallel synthesis of molecular sequence arrays on solid surfaces.12-25-2008
20090197777METHOD OF MAKING AND USING MICROARRAYS SUITABLE FOR HIGH THROUGHPUT DETECTION - Disclosed are high density microarrays and methods for making and using such microarrays. The microarrays of the present invention can have uniformly shaped and sized sensing zones and are designed to allow high-throughput detection assays with minimal noise.08-06-2009
20110130306PRO-FLUORESCENT PROBES - The present invention provides a novel class of pro-fluorescent probes for reactive oxygen species (ROS). One exemplary probe is mitochondria peroxy yellow 1 (MitoPY1), a new type of flurophore for imaging mitochondrial H06-02-2011
20090203546SOLID SUPPORTS FUNCTIONALIZED WITH PHOSPHORUS-CONTAINING DENDRIMERS, PROCESS FOR PREPARING THEM AND USES THEREOF - The present invention relates to solid supports functionalized with phosphorus-containing dendrimers, to a process for preparing them, to their use for preparing biochips and to the uses of these biochips, in particular for immobilizing molecules of interest, especially biological molecules of interest such as nucleic acids, polypeptides, lipids and proteins.08-13-2009
20080293592Method For Covalently Immobilising Biomolecules on Organic Surfaces - The invention relates to a method for covalently immobilising probe-biomolecules on organic surfaces by means of photoreactive cross-linking agents which are used for covalently immobilising the probe-biomolecules on an organic surface. The inventive immobilising method consists in applying said probe-biomolecules and photoactive polymers and afterwards in cross-linking.11-27-2008
20110212861DIRECTED SYNTHESIS OF OLIGOPHOSPHORAMIDATE STEREOISOMERS - The trivalent phosphorous atom of a compound is reacted with a reagent in such a manner that a stable phosphate mimetic or a specifier is formed. Phosphoramidites with a phosphorous atom containing at least one hydroxyl residue which is provided with a protective group are reacted for this purpose with a free hydroxyl group: In the first synthesis cycle the hydroxyl group is linked to a solid support via a cleavable or non-cleavable linker. In further synthesis cycles the hydroxyl group is created by cleavage of the protective group from the growing oligomer. This results in formation of a phosphorous acid triester which is reacted with azides. By selecting suitable monomers for the synthesis which have a defined stereoconformation compounds of Formula 1 are produced in a stereocontrolled manner.09-01-2011
20130143769Graphene Nanomesh Based Charge Sensor - A graphene nanomesh based charge sensor and method for producing a graphene nanomesh based charge sensor. The method includes generating multiple holes in graphene in a periodic way to create a graphene nanomesh with a patterned array of multiple holes, passivating an edge of each of the multiple holes of the graphene nanomesh to allow for functionalization of the graphene nanomesh, and functionalizing the passivated edge of each of the multiple holes of the graphene nanomesh with a chemical compound that facilitates chemical binding of a receptor of a target molecule to the edge of one or more of the multiple holes, allowing the target molecule to bind to the receptor, causing a charge to be transferred to the graphene nanomesh to produce a graphene nanomesh based charge sensor for the target molecule.06-06-2013
20110009292ATTACHMENT OF MOLECULES TO SURFACES - The present invention relates to methods, reagents, and substrates that can be used for, for example, immobilizing biomolecules, such as nucleic acids and proteins. In an embodiment, the present invention relates to surfaces coated with a polymer according to the present invention. In an embodiment, the present invention relates to methods for thermochemically and/or photochemically attaching molecules to a surface at a high density.01-13-2011
20110082053Molecular Rectifiers Comprising Diamondoids - Provided is a molecular rectifier comprised of a diamondoid molecule and an electron acceptor attached to the diamondoid molecule. The electron acceptor is generally an electron accepting aromatic species which is covalently attached to the diamondoid.04-07-2011
20120122735COMPOSITION, DEVICE AND ASSOCIATED METHOD - A composition includes a first probe, a first initiator component bonded to the first probe, a second probe, and a second initiator component bonded to the second probe. The first probe and the second probe are capable of binding to a single analyte, and the first initiator component and the second initiator component are capable of forming an initiator when present in proximity to each other and when the first probe and the second probe are bonded to the analyte. An associated kit, device, and method are provided.05-17-2012
20120122733COMPOSITION, DEVICE AND ASSOCIATED METHOD - The composition includes a first probe and a first initiator bonded to the first probe. The composition further includes a second probe and a second initiator bonded to the second probe. The first probe and the second probe are capable of binding to a single analyte. An associated kit, device, and method are provided.05-17-2012
20080214409Substrate structure, oligomer probe array and methods for producing the same - Disclosed are substrate structures, an oligomer probe array and methods of producing the same. The substrate structure may include a substrate, and an intermediate film including the chemical structure represented by the following Formula 1, on the substrate.09-04-2008
20110263458SUBSTRATE OF TARGET SUBSTANCE DETECTION ELEMENT TO BE USED IN APPARATUS FOR DETECTING TARGET SUBSTANCE BY UTILIZING SURFACE PLASMON RESONANCE AND DETECTION ELEMENT AND DETECTION APPARATUS USING SAME - A substrate of a target substance detection element to be used for a detection apparatus for detecting a target substance, utilizing surface plasmon resonance, comprises a base and a metal structure arranged on the surface of the base in a localized manner or a metal film having an aperture and arranged on the surface of the base, the metal structure or the aperture, whichever appropriate, having at least either of a loop section and a crossing section.10-27-2011
20110009293Nonseparation Assay Methods - Assay methods are disclosed involving specific binding reactions which are simplified compared to known methods. A compound capable of producing chemiluminescence is immobilized on a solid support as is a member of a specific binding pair for capturing an analyte from a sample. An activator compound that activates the chemiluminescent compound and is conjugated to a specific binding pair member is added in excess along with the sample to the solid support. Addition of a trigger solution causes a chemiluminescent reaction at the sites where the activator conjugate has been specifically bound. The assay methods are termed non-separation assays because they do not require removal or separation of excess detection label (activator conjugate) prior to the detection step. The methods are applicable to various types of assays including immunoassays, receptor-ligand assays and nucleic acid hybridization assays.01-13-2011
20100197521ORGANO-CASCADE CATALYSIS: ONE-POT PRODUCTION OF CHEMICAL LIBRARIES - A method for production of a chemical library is provided, where the method involves: reacting, in a single vessel, a) a plurality, x, of aldehydes and/or ketones; and b) either (i) a plurality, y, of nucleophiles, (ii) a plurality, z, of electrophiles or both (i) and (ii); in the presence of c) a cascade catalyst capable of catalyzing reaction between said plurality of aldehydes and/or ketones and said plurality of nucleophiles, said plurality of electrophiles or both; to obtain a mixture of x-y β-nucleophile substituted aldehydes and/or ketones, xz α-electrophile substituted aldehydes and/or ketones or xyz β-nucleophile substituted, α-electrophile substituted aldehydes and/or ketones; and the chemical libraries thus produced.08-05-2010
20120122734COMPOSITION, DEVICE AND ASSOCIATED METHOD - A composition includes a first probe and a first initiator bonded to the first probe. The first probe is capable of binding to an analyte and the first initiator is capable of initiating a controlled polymerization reaction. An associated kit, device, and method are provided.05-17-2012
20110105362CYANINE COMPOUNDS AND THEIR APPLICATION AS QUENCHING COMPOUNDS - The present invention provides methods and non-fluorescent carbocyanine quencher compounds having the general formula:05-05-2011
20100048421NANOCOMPOSITE STRUCTURES AND RELATED METHODS AND SYSTEMS - The disclosure relates to nanotube composite structures and related methods and systems. In particular, structures, methods and systems are provided herein to allow for precise, tunable separation between nanomaterials such as carbon nanotubes.02-25-2010
20120220493BIOMARKER FOR DIAGNOSIS, PREDICTION AND/OR PROGNOSIS OF ACUTE HEART FAILURE AND USES THEREOF - The application discloses MCAM as a new biomarker for acute heart failure; methods for predicting, diagnosing, prognosticating and/or monitoring acute heart failure based on measuring said biomarker; and kits and devices for measuring said biomarker and/or performing said methods.08-30-2012
20120258886PROTECTED AMINE LABELS AND USE IN DETECTING ANALYTES - The invention is directed towards novel amino acid based compounds, which may be isotopically enriched, and methods of use of such compounds for characterising one or more molecules of a sample by mass spectrometry, the method comprising: (a) reacting the one or more molecules with the compound; and (b) characterising the one or more molecules by mass spectrometry.10-11-2012
20120264649AGENTS FOR ENHANCED CHARGE TRANSPORT ACROSS MICROBIAL MEMBRANES - The invention provides molecules useful for enhancing charge transport across membranes, such as electron transport across membranes, and methods of using such molecules, for example in improving the performance of a microbial fuel cell or in staining microbes for observation. The amphiphilic molecule comprises a conjugated core with hydrophilic groups on either end. The amphiphilic molecule inserts into the membrane of a microbe and facilitates charge transfer across the membrane of the microbe.10-18-2012
20110212860Modulation of Bacterial Quorum Sensing With Synthetic Ligands - The present invention provides compounds and methods for modulation of the quorum sensing of bacteria. In an embodiment, the compounds of the present invention are able to act as replacements for naturally occurring bacterial quorum sensing ligands in a ligand-protein binding system; that is, they imitate the effect of natural ligands and produce an agonistic effect. In another embodiment, the compounds of the present invention are able to act in a manner which disturbs or inhibits the naturally occurring ligand-protein binding system in quorum sensing bacteria; that is, they produce an antagonistic effect. The compounds of the present invention comprise N-acylated-homoserine lactones (AHLs) comprised of a wide range of acyl groups.09-01-2011
20120088694CELL ASSAY METHODS AND ARTICLES - Versatile, efficient cell assays which can be prepared with use of nanolithography and can be used to test nanomaterials, pharmaceuticals, toxins, and the like. For example, a method comprising: depositing at least one first composition comprising at least one cell adhesion material on at least one substrate to form a pattern which forms an interior space on the substrate within the pattern, depositing in the interior space on the substrate at least one second composition, different from the first, comprising at least one material adapted to affect or potentially affect cell function. Tip-based deposition and direct-write methods can be used for deposition at nanoscale and sub-cellular resolutions. Nanoscopic and atomic force microscope tips can be used. Multiplexing can be carried out.04-12-2012
20120088693MICROARRAY CELL CHIP - Disclosed herein is a microarray cell chip. The microarray cell chip includes an upper substrate that has biomatrices encapsulating biomaterials formed on one surface thereof and through holes penetrating from one surface to the other surface thereof and a lower substrate that is coupled with the upper substrate and is provided with wells storing reagents supplied to the biomatrices. The microarray cell chip according to the present invention can smoothly transfer the culture media and the reagents to the biomaterials embedded in the biomatrices through the diffusion and simply separate the upper substrate from the lower substrate, thereby improving the easiness of washing. Therefore, the present invention provides an environment similar to the bio environment, thereby making it possible to increase accuracy of an experiment.04-12-2012
20100184622SUBSTRATE FOR BIOCHIP AND BIOCHIP - A substrate for biochips with which immobilization is easy, which does not exhibit self-fluorescence, which is easy to manufacture, and which is excellent in flatness and surface precision, is disclosed. A substrate having a substrate body of the biochip, which is made of a metal, and a carbon layer having functional groups formed on the metal substrate body is used as a substrate for biochips. Since the substrate body of the substrate for biochips is made of a metal, the substrate is not only easy to manufacture, but also free from cracking and chipping, so that it allows easy handling, and high flatness and surface precision can be attained. Therefore, the problem that the optical system is hard to focus when detecting fluorescence does not occur. Moreover, since the substrate body is made of a metal, it does not emit fluorescence by itself. In addition, since the carbon layer has functional groups such as amino groups, biologically relevant substances can be easily immobilized.07-22-2010
20080248968MATRIX-ASSISTED LASER DESORPTION IONIZATION MASS SPECTROMETRY SUBSTRATES HAVING LOW VOLUME MATRIX ARRAY ELEMENTS - Provided herein are substrates for matrix-assisted laser-desorption ionization (MALDI) mass spectrometric analysis. Each spot includes 3-hydroxypicolinic acid matrix and no analyte.10-09-2008
20110275540New Molecularly Imprinted Polymer and Method for its Production - The present invention relates to a molecularly imprinted polymer and a method of producing the same using complementary oligo- and/or polynucleotides.11-10-2011
20110257038ORGANIC CHEMICAL SENSOR WITH MICROPOROUS ORGANOSILICATE MATERIAL - Multi-layered optical sensor films are disclosed. The sensor films include a first reflective layer, a detection layer over the reflective layer, and optionally a second reflective layer over the detection layer. The detection layer contains a hydrophobic, amorphous, substantially microporous, analyte-sensitive organosilicate composition. The analyte-sensitive organosilicate composition provides an optical change in the film upon analyte exposure.10-20-2011
20110312544GENETIC ANALYSIS LOC WITH HYBRIDIZATION ARRAY WITH CALIBRATION CHAMBER CONTAINING PROBE THAT LACKS A REPORTER - A microfluidic device having a supporting substrate, an inlet for receiving a biological sample containing target nucleic acid sequences, hybridization chambers containing probes that each have a nucleic acid sequence for hybridization with the target nucleic acid sequences to form probe-target hybrids, a fluorophore and a quencher configured such that the fluorophore emits a fluorescence signal in response to an excitation light and the quencher quenches the fluorescence signal when the probe is not hybridized, but fails to quench the fluorescence signal from the probe-target hybrid, and, a calibration chamber with no fluorophore.12-22-2011
20130196879ASSAY SYSTEM - The invention provides a method of forming a plurality of re-constitutable doses of at least one drug in a plurality of wells, the method including the steps of (i) placing a known amount of said drug in a suitable carrier to form a first composition having a known concentration (ii) placing at least two selected amounts of that first composition into individual wells and (iii) converting the first composition into a transportable form that can later be converted into a second composition having a known concentration and (iv) sealing the wells.08-01-2013

Patent applications in class Library containing only organic compounds

Patent applications in all subclasses Library containing only organic compounds