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LIBRARY, PER SE (E.G., ARRAY, MIXTURE, IN SILICO, ETC.)

Subclass of:

506 - Combinatorial chemistry technology: method, library, apparatus

Patent class list (only not empty are listed)

Deeper subclasses:

Class / Patent application numberDescriptionNumber of patent applications / Date published
506015000 Library containing only organic compounds 640
506014000 Library contained in or displayed by a micro-organism (e.g., bacteria, animal cell, etc.) or library contained in or displayed by a vector (e.g., plasmid, etc.) or library containing only micro-organisms or vectors 97
506022000 Library containing only inorganic compounds or inorganic materials 9
Entries
DocumentTitleDate
20120184461PRINTING OF FSL CONSTRUCTS - Methods of manufacturing cards, strips and multiwell plates for use in diagnostic assays are described. The methods employ the use of synthetic constructs of the generic structure F-S-L (where F is an antigen for a reactive antibody, S is a spacer covalently linking F to L, and L is a lipid) as “ink” in inkjet printers. The cards, strips and multiwell plates provide a number of advantages including efficiency of manufacture and improved accuracy in determining and recording assay results.07-19-2012
20110195867METHOD OF ANALYZING PROTEIN MICROSTRUCTURE AND STRUCTURE FOR THE SAME - A method of analyzing a protein structure is provided. The method includes immobilizing capture molecules to a substrate, the capture molecules being able to capture target molecules regardless of the microstructure of the target molecules, forming a first complex by binding the capture molecules to the target molecules, forming a plurality of second complexes by binding the first complex to one of plural kinds of probe molecules, measuring a binding affinity between the first complex and the probe molecules by performing a color development to the plurality of second complexes, and confirming the target molecules by comparing the measured binding affinity with conventional data of binding affinities. Therefore, the method may be useful in analyzing the microstructure of the target protein simply using relatively simple analytical instruments or reagents without use of the expensive instruments or skilled techniques.08-11-2011
20130035258LUMINESCENT TETRAPODS DOTS AND VARIOUS APPLICATIONS - A tetrapod article and its uses are disclosed whereby such tetrapod article comprises an apex base nanomaterial and X leg base nanomaterial protruding from the apex, wherein X is an integer. In an aspect, the tetrapod article can comprise Y nanomaterial layers overcoating the apex base material and the leg base nanomaterial protruding from the apex, wherein Y is an integer. In yet another aspect, disclosed is an assay kit comprising a set of hydrophobic coated tetrapod articles coupled to K pairing moieties that are paired to L predefined targeting items to form a set of tetrapod conjugates that that correspond to M biological parameters and luminesce at respective wavelengths that correspond to the respective predefined target cell types, wherein K, L, and M are integers.02-07-2013
20100323918POLYMER SURFACE FUNCTIONALIZATION AND RELATED APPLICATIONS - A method to assemble functional materials, such as nanomaterials, onto a polymer surface to create a corresponding functionalized surface involves creating a solution of the functional material, providing a sacrificial substrate, disposing the functional solution onto a surface of the substrate and then covering the substrate with a liquid polymer. The sacrificial substrate is then dissolved, leaving behind a functional surface embedded within the cured polymer. One specific aspect of the invention relates to the embedding of functionalized carbon nanotubes onto a polymer surface for creating a nano-engineered surface. Devices employing functional surfaces are disclosed that are suitable for the immobilization of enzymes, DNA, peptides, proteins, cells, catalyst, and/or other chemicals or molecules for chemical, biochemical, or biological analysis, reactions, filtration.12-23-2010
20120165224CELL CHIP - Disclosed herein is a cell chip including: an upper substrate having a plurality of biometrics spaced therefrom by fillers, the biometrics fixing a biomaterial thereinto; a first hydrophobic coating layer formed on the upper substrate; and a lower substrate combined with the upper substrate and having a plurality of wells formed therein, the well storing fluid provided to the biometrics therein. The cell chip includes two substrates functionally separated from each other to implement a three dimensional cell chip, solves a cross contamination problem, and provides a similar environment to a bio environment, thereby making it possible to increase the accuracy of a test.06-28-2012
20090305906Microdeposition System For A Biosensor - A microdeposition pin having a contact surface with at least one concave edge for creating microarrays and the like. The microdeposition pin may be used either alone or with a plurality of microdeposition pins in conjunction with a holder. The concave edge of the pin is especially adapted for helping to control the spreading of a deposited material. By selectively controlling the spread of the reagent composition from the microdeposition pin, the flow of the reagent composition from the deposition target area may be reduced. Sensor strips having raised substrate features with limited or no spreading of the reagent composition beyond the target area are disclosed.12-10-2009
20090011953Methods and apparatuses for preparing a surface to have catalytic activity - The invention provides methods and apparatuses that utilize mass spectrometry for preparation of a surface to have catalytic activity through molecular soft-landing of mass selected ions. Mass spectrometry is used to generate combinations of atoms in a particular geometrical arrangement, and ion soft-landing selects this molecular entity or combination of entities and gently deposits the entity or combination intact onto a surface.01-08-2009
20120238474PROBE ARRAY BASE, METHOD FOR MANUFACTURING PROBE ARRAY BASE, METHOD FOR MANUFACTURING PROBE ARRAY - A probe array base including probe-holding portions which are periodically arranged on a solid base member and which have grooves is prepared by anisotropically etching a single-crystalline silicon substrate. Probe solutions are supplied to the probe-holding portions by capillary action from a plurality of tank arrays having a certain cylinder period. This allows a probe array to be completed. The probe array is used as, for example, a DNA or antigen chip, has a high degree of integration, and is capable of holding a constant and sufficient number of probe molecules.09-20-2012
20120238473Molecular sensor using temporal discrimination - A sensor device is disclosed, which depends on discrimination in time between groups of binding events of target particles to nano-electrodes. The target particles may be in the liquid phase or in suspension. The nano-electrodes form part of a sensor arrangement having a plurality of sensors. The sensor device is arranged such that different species of target particles arrive at the nano-electrodes at different times, using techniques such as chromatography or application of a field such as an electric, magnetic, or gravitational field. The particles may be labelled or unlabeled. The invention is particularly suited, but not limited, to sensing bioparticles.09-20-2012
20090203544METHOD AND USE OF A PRINTER DEVICE FOR PRODUCING BIOLOGICAL TEST ARRAYS - The invention relates to a printer device for producing biological test arrays by depositing an array of biofluids onto a substrate. The invention further relates to the use of such a device in the production of biological test arrays. The invention also relates to a method for producing a biological test array. The invention moreover relates to a biological test array. The method according to the invention is failure-proof, and results in biological test arrays of superior quality.08-13-2009
20120196771HIGH SPEED, HIGH FIDELITY, HIGH SENSITIVITY NUCLEIC ACID DETECTION - Methods, compositions, and kits for nucleic acid detection.08-02-2012
20090088343METHOD OF PATTERNING AND PRODUCT(S) OBTAINED THEREFROM - The present invention provides a method of patterning, the method comprising the steps of: (a) providing a porous film; and (b) adding at least one structure to the porous film. The present invention also provides a patterned film prepared according to the method of the invention. The present invention also provides a method of preparing a porous film, and a porous film prepared according to the method of the invention.04-02-2009
20100285992 MICRO-PATTERNED PLATE COMPOSED OF AN ARRAY OF RELEASABLE ELEMENTS SURROUNDED WITH SOLID OR GEL WALLS - A micro-patterned plate composed of an array of releasable elements surrounded by a gel or solid wall and methods of manufacture of the micropatterned plate. The surface properties of walls can be tailored if needed to be repellent or attracting to proteins. The walls can also inhibit cell attachment. The walls enable cells or other materials to be localized to the tops of the releasable elements. The individual element in the array of releasable elements can be released from the array by a mechanical force.11-11-2010
20110287977NANOSCALE SENSORS - A nanocoaxial sensor includes an outer conductor, an inner conductor, a dielectric material disposed between the outer and inner conductors, a nanocavity sized to allow target species to enter the nanocavity between the outer and inner conductors, and an active sensing element immobilized within the nanocavity on at least one of the inner or outer conductors. The active sensing element is adapted to selectively capture the at least one of the target species.11-24-2011
20090011954Thin Sheet for Retaining Biomolecules - This invention has application in a variety of biological and biochemical fields. The invention describes a thin sheet or sheets of flexible material with surface characteristics that provide an environment for retaining biological molecules. The flexible nature of the thin sheet of material permits the use of continuous preparation, processing and analysis techniques involving more compact and less complex equipment. The invention also describes a lamination of a thin sheet of flexible material to a substantially rigid second substrate so that the combination can be processed by existing equipment. The thin sheet of flexible material may be perforated prior to lamination in order to establish distinct wells in the surface of the lamination.01-08-2009
20120035081NON-POLAR SOLID INKS FOR BIOMEDICAL APPLICATIONS - A microfluidic device includes a first substrate, and a phase change ink deposited on a surface of the first substrate. The phase change ink includes a non-polar polymeric material and an optional colorant, wherein the phase change ink is solid at room temperature but is liquid at a jetting temperature of from about 60 to about 150° C., and a water contact angle on the deposited phase change ink is from 90° to about 175°.02-09-2012
20100087333PROCESS OF FABRICATING TISSUE ARRAY BLOCK, PROCESS OF FABRICATING TISSUE ARRAY SHEET, TISSUE ARRAY BLOCK, TISSUE ARRAY CHIP, SYSTEM OF FABRICATING TISSUE ARRAY BLOCK AND SYSTEM OF FABRICATING TISSUE ARRAY SHEET - [Task] A process of fabricating a tissue array block; a process of fabricating a tissue array sheet; a tissue array block; a tissue array chip; a system of fabricating a tissue array block; and a system of fabricating a tissue array sheet are proposed, in which the tissue array block can be fabricated even in the case of that having a small thickness, is little affected by tissue hardness and, when having been processed into a tissue array chip, does not suffer any defect in a piece of tissue or at a site of interests, enables the collection of pieces of tissue from a dispersed area, also enables the establishment of positional relationship between the inside of a tissue piece and the inside of a tissue block, and scarcely affects the utilization of the tissue block remaining after collecting the pieces of tissue.04-08-2010
20100120631Methods for detecting hepatocellular carcinoma - A method for evaluating hepatocellular carcinoma in a subject is provided. In certain embodiments, the method comprises: a) obtaining a hepatocellular carcinoma protein marker profile for a sample obtained from the subject; and b) comparing the protein marker profile to a control profile.05-13-2010
20100120630METHODS AND DEVICES FOR BIOMOLECULAR ARRAYS - The disclosure provides methods and devices for rapidly assembling high density biomolecular arrays.05-13-2010
20080305964Single-Step Platform for On-Chip Integration of Bio-Molecules - Novel compounds having a functionalized group capable of binding to a solid substrate; a photoactivatable group capable of generating a reactive group upon exposure to light and being for binding a screenable moiety; and a polymer capable of forming a monolayer on a solid substrate, and having the functionalized group and to the photoactivatable group attached thereto and processes for the preparation thereof are disclosed. Further disclosed are arrays of screenable moieties (e.g., nucleic acids, proteins, carbohydrates, substrates, chelating agents and many more) prepared using these novel compounds.12-11-2008
20080312100Hybridization Method as Well as Hybridization Microarray and Hybridization Kit - A method of simply and reliably hybridizing a sample biopolymer using a glass coverslip and a closed vessel by hybridizing the sample biopolymer and a probe biopolymer with each other in a state that a solution containing the sample biopolymer is in contact with only a slide glass to which the probe biopolymer is immobilized in a closed vessel containing a solution having the same vapor pressure as the solution containing the sample biopolymer is provided. A microarray and a kit for hybridization employed for the present invention are also provided.12-18-2008
20090054264Method of Fabricating an Array of Capillaries on a Chip - The invention relates to a method of fabricating an array of capillaries of a chip, the method comprising the steps consisting in depositing at least one layer of a meltable or polymerizable construction material on a support plate, focusing and moving a laser beam on and over said layer respectively to melt or polymerize the material so as to form the side walls of the capillaries, and then fastening a cover plate on the side walls of the capillaries. The invention also provides a chip including an array of capillaries in which chemical or biological molecules are fixed, and a chip including an array of chromatography and/or electrophoresis capillaries.02-26-2009
20080261830Probe Array Base, Method for Manufacturing Probe Array Base, Method for Manufacturing Probe Array - A probe array base including probe-holding portions which are periodically arranged on a solid base member and which have grooves is prepared by anisotropically etching a single-crystalline silicon substrate. Probe solutions are supplied to the probe-holding portions by capillary action from a plurality of tank arrays having a certain cylinder period. This allows a probe array to be completed. The probe array is used as, for example, a DNA or antigen chip, has a high degree of integration, and is capable of holding a constant and sufficient number of probe molecules.10-23-2008
20080261829ANTIBODY-BASED ARRAYS FOR DETECTING MULTIPLE SIGNAL TRANSDUCERS IN RARE CIRCULATING CELLS - The present invention provides antibody-based arrays for detecting the activation state and/or total amount of a plurality of signal transduction molecules in rare circulating cells and methods of use thereof for facilitating cancer prognosis and diagnosis and the design of personalized, targeted therapies.10-23-2008
20110143961IDENTIFICATION OF BODY FLUIDS USING RAMAN SPECTROSCOPY - The present invention relates to a method of identifying types of body fluids in a sample. This method involves providing a sample potentially containing one or more types of body fluids. The sample is subjected to Raman spectroscopy to produce a Raman spectroscopic signature for the sample. The Raman spectroscopy signature is identified to ascertain the types of body fluids in the sample. A method of establishing a reference Raman spectroscopic signature for specific types of body fluids is also disclosed as is a library of such reference signatures is also disclosed.06-16-2011
20090099039BINARY-COUPLED PROBE ARRAY, BIOCHIP, AND METHOD OF FABRICATION - A binary-coupled type probe array for analyzing components of a biological sample using probes, a biochip, and a method of fabricating the same, are provided. The binary-coupled probe array can include a substrate, a plurality of first probes immobilized on a top surface of the substrate, and a plurality of second probes immobilized on a bottom surface of the substrate.04-16-2009
20100160181Cooling, condensation and freezing of atmospheric water or a microfluidic working-material in or on microfluidic devices - Condensation of water from a gas, such as from atmospheric air or other nearby ambient gas, is provided for use in a variety of jetting devices, such as lab-on-a-chip applications. Further embodiments involve the use of frozen liquids, not limited to frozen condensed water, and microcooling of fluidic components or working materials for improved process control and reliability.06-24-2010
20120142557SLIDE CONDITIONING SYSTEMS AND METHODS - A slide-loader system for preparing a microarray slide having a hybridized reaction area for washing, and which includes an immersion tray which contains a volume of wash buffer fluid, and a stripping jig that holds the microarray slide during removal of a reaction chamber housing that is mounted about the hybridized reaction area.06-07-2012
20090270276BEAD IMMOBILISATION METHOD AND BEAD ARRAYS MADE THEREBY - A bead immobilization method including receiving at least one bead in at least one well in a casting surface, and casting a casting material over the casting surface to form a reverse casting in which the at least one bead is cast onto at least one post upstanding from a surface of the reverse casting.10-29-2009
20110237460MICROARRAY PACKAGE DEVICE AND METHOD OF MANUFACTURING THE SAME - A microarray package device and a method of manufacturing the same. An effective microarray analyzing reaction is performed by using the microarray package device that provides structural stability and reliable experimental results.09-29-2011
20100323919SAMPLE MULTIPROCESSING - A sample processing vessel may include a branch segment and at least two tracks. The at least two tracks may be fluidly isolated from one another by a permanent seal. The tracks may be segmented by breakable seals. The branch segment may be temporarily isolated from the tracks by breakable seal(s) and put in fluid communication with the tracks once those seal(s) are broken, such that fluid received by the branch segment is divided into portions that pass into both tracks.12-23-2010
20110245107SELECTIVE DIFFERENTIATION, IDENTIFICATION, AMD MODULATION OF HUMAN TH17 CELLS - The embodiments provide for the modulation of both the differentiation and activity of human TH17 cells. More specifically, human TH17 cell differentiation can modulated by TGF-? and IL-21, and their agonists and antagonists. Function of TH17 cells can be modulated by, for example, BLT1 or podoplanin, and their agonists and antagonists. Additionally, the embodiments provide for the identification of TH17 cells. More specifically, human TH17 cells specifically upregulate BLT1 and podoplanin. 10-06-2011
20110098199Microreactor Array - Provided is a microreactor array, comprising a single fibre comprising a matrix material; a plurality of capillaries formed within the matrix material, the capillaries substantially aligned along a longitudinal axis of the fibre; and one or more reagent associated with an inner surface of the capillaries; wherein each capillary corresponds to a microreactor of the array. Also provided are microreactor array methods and systems, including a manifold microreactor system and a microreactor array system microchip.04-28-2011
20110251105METHODS FOR DETECTING TARGET ANALYTES AND ENZYMATIC REACTIONS - A microsphere-based analytic chemistry system and method for making the same is disclosed in which microspheres or particles carrying bioactive agents may be combined randomly or in ordered fashion and dispersed on a substrate to form an array while maintaining the ability to identify the location of bioactive agents and particles within the array using an optically interrogatable, optical signature encoding scheme. A wide variety of modified substrates may be employed which provide either discrete or non-discrete sites for accommodating the microspheres in either random or patterned distributions. The substrates may be constructed from a variety of materials to form either two-dimensional or three-dimensional configurations. In a preferred embodiment, a modified fiber optic bundle or array is employed as a substrate to produce a high density array. The disclosed system and method have utility for detecting target analytes and screening large libraries of bioactive agents.10-13-2011
20080280780METHODS FOR THE PRODUCTION OF SENSOR ARRAYS USING ELECTRICALLY ADDRESSABLE ELECTRODES - Methods for building sensor arrays using electrical signals to selectively functionalize individual electrodes in an array of electrically addressable electrodes are provided. These methods are useful for providing sensor arrays for use in chemical and biochemical assays. The method is based on the sequential electrochemical reduction of functional groups on individual electrodes in order to selectively promote the functionalization of selected electrodes with selected binding entities.11-13-2008
20110053799METHOD OF PRODUCING MICROARRAY SUBSTRATE, RADIATION-SENSITIVE COMPOSITION, PARTITION OF MICROARRAY SUBSTRATE, METHOD OF PRODUCING BIOCHIP, AND BIOCHIP - A method is of producing a microarray substrate that includes a substrate, a partition that is formed on a surface of the substrate, and an area that is positioned over the substrate and defined by the partition. The method includes forming a first film on the substrate using a radiation-sensitive composition. The radiation-sensitive composition includes a coloring agent (A) including at least one of a violet pigment (a2) and a compound (a1) shown by a formula (1) in which each of R03-03-2011
20100285991COMBINATORY ANALYTICAL STRIP - A combinatory analytical strip including a substrate is disclosed. A first channel for a biochemical assay and a second channel for an immunological assay are provided concavely on an upper surface of the substrate. The results of both assays are detected by a sensor. Each channel includes a first area for receiving a fluid sample, a second area for delivering the fluid sample and a third area where the fluid sample reacts. These three areas are connected successively. A nitrocellulose layer having a hollow-matrix conformation is formed at a bottom of each of the second and third areas of both channels. Each of the nitrocellulose layers of the second areas comprises an average thickness that is not greater than that of each the nitrocellulose layers of the third areas. A reaction material is formed in the hollow-matrix conformation. The third areas of the first and second channels are both located on a line conforming a relative motion path of the sensor and the combinatory analytical strip.11-11-2010
20110190166ERYTHROID PROGENITOR CELLS AND METHODS FOR PRODUCING PARVOVIRUS B19 THEREIN - The disclosure relates to erythroid progenitor cells and methods for producing parvovirus B 19 in the cells. The invention includes transformed and/or immortalized CD36+ erythroid progenitor cells permissive for B19 infection and methods for producing useful quantities of B 19 in the cells described herein. Infectious virus produced by the cells of the disclosure is useful for identifying and developing therapeutically effective compositions for treatment and/or prevention of human parvovirus B 19 infections.08-04-2011
20110263456TEST ELEMENT WITH NANOFIBERS - The invention concerns test elements, in particular diagnostic test elements, for determining the presence or concentration of biological, medical or biologically or medically effective substances including nucleic acids, proteins, viruses, microorganisms and cells, characterized in that these test elements contain nanofibers.10-27-2011
20110306519METHOD OF FORMING POLYMERIC MICROARRAY SUPPORT - In combination, a polymeric microarray support for an optical assay arrangement, that includes an optical detection instrument having a known depth of focus for detecting light emitted from said microarray support. The polymeric microarray support has a support surface made from a polymeric support material having a thickness varying over the area of the support surface by a thickness variation value. The said support includes formed microfeatures made up of grooves arranged to have a predetermined depth at the time of forming, the groove depth being selected based on the depth of focus of the optical detection instrument and the thickness of the support. The sum of the depth for the grooves and the thickness variation value of the polymeric support surface substantially corresponds to the depth of focus of the optical detection instrument in order to reduce noise, the polymeric support surface having attached thereto probe molecules to form binding sites.12-15-2011
20080274912Single Walled Carbon Nanotubes Functionally Adsorbed to Biopolymers for Use as Chemical Sensors - Chemical field effect sensors comprising nanotube field effect devices having biopolymers such as single stranded DNA functionally adsorbed to the nanotubes are provided. Also included are arrays comprising the sensors and methods of using the devices to detect volatile compounds.11-06-2008
20120015848DISPOSABLE REACTION VESSEL WITH INTEGRATED OPTICAL ELEMENTS - The present invention provides disposable, semi-reusable, or single use reaction vessels with integrated optical elements for use with diffraction based assay systems. The vessel for assaying liquids for analytes includes a housing having at least one chamber or well for receiving a liquid therein and an optical element integrally formed with the housing for directing an incident light beam towards the well or chamber and directing a light beam away from the chamber after the light beam has interacted with analytes present in the liquid. The vessel may be test tube such as a blood collection tube, with or without, an optical element but having a pattern of analyte-specific receptors located on an inner surface of the tube wall so that when a liquid is introduced into the interior of the test tube analytes present in the liquid can bind with the pattern of analyte-specific receptors.01-19-2012
20120021951Apparatus for Assay, Synthesis and Storage, and Methods of Manufacture, Use, and Manipulation Thereof - The invention features methods of making devices, or “platens”, having a high-density array of through-holes, as well as methods of cleaning and refurbishing the surfaces of the platens. The invention further features methods of making high-density arrays of chemical, biochemical, and biological compounds, having many advantages over conventional, lower-density arrays. The invention includes methods by which many physical, chemical or biological transformations can be implemented in serial or in parallel within each addressable through-hole of the devices. Additionally, the invention includes methods of analyzing the contents of the array, including assaying of physical properties of the samples.01-26-2012
20120157346Programmable illumination pattern for transporting microparticles - The present application provides a set of fundamental operations enabling interactive control over the creation and placement of planar arrays of several types of particles and biomolecules and the manipulation of array shape and size. The present invention enables sample preparation and handling for diagnostic assays and biochemical analysis in an array format, and the functional integration of these operations. In addition, the present invention provides a procedure for the creation of material surfaces with desired properties and for the fabrication of surface-mounted optical components.06-21-2012
20120208723OLIGOMER PROBE ARRAY WITH IMPROVED SIGNAL-TO-NOISE RATIO AND DETECTION SENSITIVITY AND METHOD OF MANUFACTURING THE SAME - An oligomer probe array with improved signal-to-noise ratio and desired detection sensitivity even when a reduced design rule is employed includes a substrate, a plurality of probe cell active regions formed on or in the substrate, each of the plurality of probe cell active regions having a three-dimensional surface and being coupled with at least one oligomer probe with its own sequence, and a probe cell isolation region defining the probe cell active regions and having no functional groups for coupling with the oligomer probes on a surface.08-16-2012
20100048420Biochip and Method for Forming the Same - The present invention discloses a biochip and the forming method thereof. The disclosed biochip comprises a substrate and a divalent metal compound layer on the substrate. The method for forming a biochip comprises two major steps. The first step is providing a substrate, and the second step is forming a divalent metal compound layer on the substrate.02-25-2010
20110046013METHOD TO GENERATE BIOMOLECULAR MICRO- AND NANO-PATTERNS BY PARTICLE PRINTING LITHOGRAPHY - Methods for preparing useful patterns of biomolecules on solid supports employ particle printing lithography techniques whereby suspensions of different bioconjugates are loaded onto portions of a master pattern formed by a series of portions in a support that are compatible with an attractive force to which the bioconjugates respond. The master pattern of the bioconjugates can then be transferred to a biocompatible matrix for biological and medical applications.02-24-2011
20100204061Method and system for determining whether a drug will be effective on a patient with a disease - A process of determining whether a patient with a disease or disorder will be responsive to a drug, used to treat the disease or disorder, including obtaining a test spectrum produced by a mass spectrometer from a serum produced from the patient. The test spectrum may be processed to determine a relation to a group of class labeled spectra produced from respective serum from other patients having the or similar clinical stage same disease or disorder and known to have responded or not responded to the drug. Based on the relation of the test spectrum to the group of class labeled spectra, a determination may be made as to whether the patient will be responsive to the drug.08-12-2010
20100130380Biochip substrate and biochip - A biochip substrate which is free from cross-contamination due to spot spreading or contact with spots adjacent to each other, and a biochip using the same. A biochip substrate on which multiple valleys for immobilizing biological substances are formed so as to prevent cross-contamination due to spot spreading or contact with spots adjacent to each other, and a biochip using the same are provided. Moreover, it is found out that a desired binding in a target molecule contained in a test sample occurs at a detectable level in a solution system even in the case where a valley have such a small capacity as 1 nL to 10 nL.05-27-2010
20080255002Genetic manipulation method - A method of inducing transposition in a transgenic embryo, sperm and egg is described, comprising the steps of (a) generating a first adult transgenic organism comprising within its genome one or more copies of a transposon; (b) generating a second adult transgenic organism comprising within its genome one or more copies of a gene encoding a transposase cognate for the transposon and/or a sequence capable of regulating expression of the gene encoding the transposase; (c) crossing the first adult transgenic organism with the second transgenic adult organism to provide a progeny which comprises, in the genome of one or more of its cells, both (i) one or more copies of the transposon and (ii) a gene encoding a transposase cognate for the transposon, wherein the gene encoding the transposase is under the control of one or more inducible regulatory sequences which permit expression of the transposase, and (d) expressing the gene encoding the transposase in the embryo, sperm or egg to cause mobilisation of the transposon within a portion of the tissues or cells of the progeny. Using the method, mobilisation of a transposon can advantageously be induced at predetermined stages of development of an embryo, sperm or egg and the mutated gene of a single cell may be replicated in subsequent cell divisions, resulting in groups of cells which are essentially homogenous for the transposed gene.10-16-2008
20080227657System and method for the preparation of arrays of biological or other molecules - A method of separating species in a mixture of molecules, particles or atoms and collecting the separated species is described. The method comprises the steps of converting by ionization the species in the mixture to gas phase ions, separating the gas phase ions according to their mass charge ratio and/or mobility and collecting the separated ions. The system includes ionizing means such as electrospray to form the gas phase ions. The gas phase ions are separated by filtering, or in time or in space and soft-landed for collection such as on a surface.09-18-2008
20080220985Method for Generating Microscopic Patterns of Protein and Other Macromolecules - Methods and apparatuses for generating microscopic patterns of macromolecules such as proteins on a solid surface are described. Pulsed laser light is used to alter surface portions of a solid surface substrate in a predetermined pattern, by removing macromolecules from surface portions of the substrate where the light is focused. The same wavelength light at lower intensity can be used to visualize the removal by its reflection from the specimen surface along the path to the detector. Select macromolecules introduced to the substrate selectively adhere to select surface portions, thereby depositing macromolecules in the predetermined pattern on the solid surface.09-11-2008
20110212859RADIO FREQUENCY IDENTIFIERS FOR USE IN BIOLOGICAL SCIENCE - Provided herein are biological research methods, kits, and products that utilize radio frequency identifier technology.09-01-2011
20130150262Method and Kit for Identifying Compounds Capable of Inhibiting Human Papilloma Virus Replication - This invention provides a method, kit and an in vitro system for identifying compounds capable of inhibiting Human Papilloma Virus replication at all the stages of viral replication cycle. The method, kit and in vitro system is applicable to all types of Human Papilloma Virus. The method enables high throughput screening of compounds inhibiting HPV replication in one or more phases of the cycle.06-13-2013
20130102500Microarray Comprising Immobilisation Particles - A microarray comprises a carrier substrate and a plurality of immobilization particles configured to immobilize capture molecules. Each immobilization particle comprises a first sub-section bonded to the carrier substrate and a second sub-section which is exposed.04-25-2013
20100317545LATENT HARDENER FOR EPOXY COMPOSITIONS - Disclosed herein is a curing agent for epoxy resins that is comprised of the reaction product of an amine, an epoxy resin, and an elastomer-epoxy adduct. Additionally disclosed is a process comprising agitating a solution of an amine, an epoxy resin, and an elastomer-epoxy adduct as a dispersant at an elevated temperature in an organic medium.12-16-2010
20120283138System and device for reporting a result of an evaluation of a sample after queuing the result for transmission - A system or device includes an evaluation module for automatically evaluating, remotely from a health care facility, a biological sample acquired from a subject for a presence or an absence of at least one pathogen in the biological sample; an electronic memory for queuing a first result of the evaluation for transmission to an off-site entity; and a reporting module for reporting a second result of the evaluation to the subject after queuing the first result of the evaluation for transmission.11-08-2012
20130157897METHOD AND APPARATUS FOR MAGNETIC STIRRING - A system for combinatorially processing a substrate is provided. The system includes a reactor or chemical library having a plurality of chambers defined within the reactor or library, the chambers operable to mix fluids disposed therein. A drive system is disposed below a bottom surface of the reactor. The drive system is operable to rotate a plurality of support plates below the surface of the substrate. The plurality of support plates has a non-circular shape. The non-circular shape of adjacent support plates includes extensions configured to traverse overlapping regions of rotation during rotation of adjacent support plates. Each of the extensions has a magnet disposed thereon.06-20-2013
20130184182BIO CHIP - There is provided a bio-chip including a first substrate including a plurality of micro-pillars protruded from one surface thereof to a predetermined height and having a biomaterial adhered to protruded surfaces of the plurality of micro-pillars, wherein the first substrate is formed of a resin composition including 100 parts by weight of polystyrene and 5 to 30 parts by weight of maleic anhydride.07-18-2013
20110312542GENETIC ANALYSIS LOC WITH HYBRIDIZATION ARRAY WITH CALIBRATION CHAMBER CONTAINING CHAMBER WITH A BLOCKED INLET SPOTTED WITH REPORTER - A microfluidic device having a supporting substrate, an inlet for receiving a biological sample containing target nucleic acid sequences, hybridization chambers in fluid communication with the inlet, the hybridization chambers containing probes that each have a nucleic acid sequence for hybridization with the target nucleic acid sequences to form probe-target hybrids, a fluorophore and a quencher configured such that the fluorophore emits a fluorescence signal in response to an excitation light and the quencher quenches the fluorescence signal when the probe is not hybridized, but fails to quench the fluorescence signal from the probe-target hybrid, and, a calibration chamber not in fluid communication the inlet, wherein, the calibration chamber contains a fluorophore.12-22-2011
20110312541LOC FOR DETECTION OF HYBRIDIZATION OF NUCLEIC ACID SEQUENCES WITH PRIMER-LINKED LINEAR PROBES - A LOC device having a supporting substrate, a primer-linked, linear probe with a nucleic acid sequence that matches a target nucleic acid sequence, and a primer for elongating against the target nucleic acid sequence to form a complementary sequence such that during use the nucleic acid sequence matching the target nucleic acid sequence anneals to the complementary sequence to change a fluorescence emission from the probe in response to an excitation light, and, CMOS circuitry on the supporting substrate, the CMOS circuitry having operative control of the excitation light.12-22-2011
20110312540LOC DEVICE FOR DETECTING TARGET NUCLEIC ACID SEQUENCES USING ELECTROCHEMILUMINESCENT PROBES AND CALIBRATION PROBES LACKING A LUMINOPHORE - A lab-on-a-chip (LOC) device for detecting target nucleic acid sequences in a fluid, the LOC device having electrochemiluminescent (ECL) probes for detecting the target nucleic acid sequences, each of the ECL probes having an ECL luminophore for emitting photons when in an excited state, a functional moiety for quenching photon emission from the ECL luminophore by resonant energy transfer, calibration probes without an ECL luminophore, and, electrodes for receiving an electrical pulse to excite the ECL luminophores.12-22-2011
20110312539LOC DEVICE WITH ELECTROCHEMILUMINESCENT PROBES FOR DETECTING TARGETS IN A FLUID AND A POSITIVE CONTROL PROBE WITHOUT A QUENCHER FOR LUMINOPHORE EMISSIONS - A lab-on-a-chip (LOC) device for detecting target nucleic acid sequences in a fluid, the LOC device having electrochemiluminescent (ECL) probes for detecting the target nucleic acid sequences, each of the probes having an ECL luminophore for emitting photons when in an excited state, a functional moiety for quenching photon emission from the ECL luminophore by resonant energy transfer, at least one positive control probe that has the ECL luminophore but not the functional moiety for quenching photon emission, and, electrodes for receiving an electrical pulse to excite the ECL luminophores.12-22-2011
20110312538LOC DEVICE WITH ELECTROCHEMILUMINESCENT PROBES FOR DETECTING TARGETS IN A FLUID AND A POSITIVE CONTROL PROBE FOR DETECTING A NUCLEIC ACID SEQUENCE KNOWN TO BE PRESENT - A lab-on-a-chip (LOC) device for detecting target nucleic acid sequences in a fluid, the LOC device having electrochemiluminescent (ECL) probes for detecting the target nucleic acid sequences, each of the probes having an ECL luminophore for emitting photons when in an excited state, a functional moiety for quenching photon emission from the ECL luminophore by resonant energy transfer, at least one positive control probe for detecting a nucleic acid sequence known to be always present in the fluid, and, electrodes for receiving an electrical pulse to excite the ECL luminophores.12-22-2011
20110312537LOC DEVICE FOR AMPLIFYING AND DETECTING TARGET NUCLEIC ACID SEQUENCES USING ELECTROCHEMILUMINESCENT RESONANT ENERGY TRANSFER, LINEAR PROBES WITH COVALENTLY ATTACHED PRIMERS - A lab-on-a-chip (LOC) device for amplifying and detecting target nucleic acid sequences, the LOC device having electrochemiluminescent (ECL), resonant energy transfer, linear probes for hybridization with the target nucleic acid sequences, each of the probes having a linear portion containing a sequence complementary to the target nucleic acid sequence, an ECL luminophore for emitting photons when in an excited state, a functional moiety for quenching photon emission from the ECL luminophore by resonant energy transfer, and a covalently attached primer for extension along a complementary sequence denatured from the target nucleic acid sequence to replicate the target nucleic acid sequence, heaters for thermally cycling the target nucleic acid sequences through a polymerase chain reaction (PCR), in which the covalently attached primers anneal to oligonucleotides containing the target nucleic acid sequences, and, electrodes for receiving an electrical pulse to excite the ECL luminophores, wherein during use, replicating the target nucleic acid sequence causes the linear portion to dissociate from the functional moiety such that the complementary nucleic acid sequence therein hybridizes to the target nucleic acid sequence and photons emitted by the ECL luminophore are not quenched.12-22-2011
20120094869MICROPLATE ASSAY KIT - The present invention provides a microplate-based assay kit that incorporates all assay reagents and standards in a simple and efficient format and may be used in biochemical assays. The assay kit includes pre-filled, pre-sealed and barcoded microplates with a standard physical footprint for use in a microplate-based automated analyzer system which enables simple and efficient operation by an unskilled user via per-use factory-sealed and barcoded reagent and calibrator microplates. Such microplates allow the user to run a broad test menu without the need to monitor the arrangement and supply of internally stored reagents and standards, thus greatly simplifying the user experience and eliminating the need for highly skilled users.04-19-2012

Patent applications in class LIBRARY, PER SE (E.G., ARRAY, MIXTURE, IN SILICO, ETC.)

Patent applications in all subclasses LIBRARY, PER SE (E.G., ARRAY, MIXTURE, IN SILICO, ETC.)