Class / Patent application number | Description | Number of patent applications / Date published |
436175000 | Digestion or removing interfering materials | 22 |
20090317918 | METHOD OF HEATING LIQUID MEDIUM USING MICROWAVES AND ANIONS - Provided is a method comprising adding anions having a high charge density to a liquid medium; the liquid medium comprising molecules that hydrogen bond with one another; the anions interacting with the molecules of the liquid medium with a force that is stronger than the forces that produce hydrogen bonding between the molecules of the medium; and heating the liquid medium by irradiating it with microwaves. | 12-24-2009 |
20100227413 | High Temperature High Pressure Vessel for Microwave Assisted Chemistry - A vessel assembly is disclosed for high pressure high temperature chemistry. The vessel assembly includes a cylindrical vessel and a cylindrical vessel seal cover. The vessel and the seal cover have respective surfaces that, when engaged, define a circumferential interior passage between the vessel and the seal cover. A pressure release opening in the seal cover is in fluid communication with the circumferential passage. A retaining ring surrounds the vessel and the seal cover at the position where the vessel and the seal cover meet to maintain an outer circumferential engagement between the seal cover and the vessel when pressure forces gases in the vessel to flow into the circumferential passage and then outwardly from the pressure release opening. | 09-09-2010 |
20110033949 | TEFLON CONTAINER FOR SAMPLE DECOMPOSITION USING GAS CONDENSATION BY AIR COOLING - When an atomic absorption spectrophotometer (AAS) or inductively coupled plasma (ICP) is used, samples must be introduced in a liquid state. Thus, sample decomposition by acids must be performed. Methods for decomposing samples using beakers or microwaves have caused several problems such as loss of volatile elements, excessive use of acids, emission of harmful gases, limitation of sample capacity and amount, and inconvenience of cleaning up. However, the present invention can treat many samples with one acid injection through gas condensation by both heating of a reaction container and air cooling of a collection pipe, wherein the reaction container is made of fluororesin (Teflon) or quartz. Also, if there are many samples, the samples can be treated at once. Furthermore, since the present invention can treat the samples with a conventional heating plate, the invention can be used at inexpensive costs. Additionally, since harmful gases or volatile elements generated in decomposition are condensed in an absorption pipe, anticorrosive effects and accurate data can be obtained. Also, the invention can reduce reagents and prevent both contamination of samples caused by concentration of reagents and air pollution caused by harmful gases generated during decomposition. | 02-10-2011 |
20110039351 | High Temperature High Pressure Vessel for Microwave Assisted Chemistry - A method of conducting microwave-assisted high pressure high temperature chemistry is disclosed. The method includes the steps of digesting a sample in a strong acid at a temperature of at least 200° C. in a pressure resistant vessel that includes a lid while exerting a defined force against the lid in order to maintain gases under pressure in the vessel; directing gas under excess pressure from the vessel into a circumferential passage defined by the vessel and its pressure resistant lid; and directing the gas from the circumferential passage outwardly from the lid while preventing gas from flowing outwardly over the edge of the vessel. | 02-17-2011 |
20110151577 | DISPOSABLE DEVICE FOR AUTOMATED BIOLOGICAL SAMPLE PREPARATION - A device and a process for preparing biological test samples are presented. The device has a disposable device with a connection mechanism for connecting to a closed sonication tube together with a filter capture unit to capture samples and to handle the samples without requiring additional tubes. With the device and/or method, samples are sonicated in the closed sonication tube that prevents aerosol contamination. | 06-23-2011 |
20110165695 | ANALYTE IONIZATION BY CHARGE EXCHANGE FOR SAMPLE ANALYSIS UNDER AMBIENT CONDITIONS - Electrospray ionization techniques are used to generate reagents that ionize analytes for mass spectrometric analysis by charge transfer. Such techniques may be performed under ambient conditions. Suitable precursors for such reagents include ionizable nonpolar solvents, such as toluene or xylenes, polar solvents, such as water or alcohols, inert gases, such as helium or nitrogen, or combinations thereof. Environmental conditions in the ionization chamber of the mass spectrograph can be manipulated to generate a selected ion of an analyte in preference to other ions. | 07-07-2011 |
20110201126 | INTERFACE TO A MASS SPECTROMETER - An interface is provided for coupling a sample source, including a TOC/TN analyzer to an isotope detector, including an isotope ratio mass spectrometer. The interface comprises a sample conduit having an inlet for fluid connection with the sample source and an outlet for fluid connection with the isotope detector. A sample trap is fluidly connected in the sample conduit. A helium bypass conduit is has an inlet for fluid connection with a helium supply line and an outlet for fluid connection with the sample conduit. The interface traps the target sample while contaminants are exhausted. The sample is released from the sample trap and is carried to the isotope detector on a stream of helium. Effluent contaminants are not held in the interface. There is no significant fouling of the interface or contamination of samples carried to the isotope detector. | 08-18-2011 |
20110201127 | INDEPENDENT HEATING OF SAMPLES IN A SAMPLE HOLDER - There is described a heating system for independently heating at least one sample recipient containing a sample, the sample recipient provided in a sample holder, comprising: a heating chamber having at least one opening and adapted to receive the sample holder; at least one microwave generator for generating microwaves; at least one microwave applicator inside the heating chamber connected to the at least one microwave generator, the at least one microwave applicator comprising an oven cavity portion for creating a mini microwave cavity around a single sample recipient in the sample holder, and for applying microwaves generated by the at least one microwave generator directly to the single sample recipient; and a control unit for controlling the at least one microwave generator. | 08-18-2011 |
20110263040 | DEVICES AND METHODS FOR REDUCING MATRIX EFFECTS - Devices and methods are provided for reducing matrix effects in protein precipitated bioanalytical samples comprising: a support, and a sorbent associated with the support capable of binding matrix interfering agents present in the bioanalytical sample, wherein the device further comprises filtering means for removing precipitated protein particles. The filtering means is a size exclusion filter or a polymeric or inorganic monolith having a maximum pore size less than or equal to the diameter of the particles to be removed from the sample, and can be integral with the sorbent or associated with the sorbent. The sorbent is characterized by sufficient selectivity between the matrix interfering agents and analytes of interest to provide retention of the matrix interfering agents while providing elution of the analytes of interest (e.g., a reversed phase or a polar modified reversed phase). Typical devices incorporating these features include luer syringe filters, individual filter cartridges, multiwell plates, pipette tips, or inline columns for multiple or single use. | 10-27-2011 |
20120028367 | REMOVING POLYPEPTIDES FROM STOOL - This document provides methods and materials involved in removing polypeptides (e.g., high abundance polypeptides) from stool samples. For example, methods and materials for preparing a stool sample for detecting polypeptides of low abundance are provided. | 02-02-2012 |
20120070907 | METHOD TO DEPLETE MONOCLONAL ANTIBODIES IN A BIOLOGICAL SAMPLE - The present invention provides methods for depleting a biological sample from a patient of a humanized or chimeric monoclonal antibody prior to cross-matching the sample for transplantation. The method comprises treating the sample with a peptide or other moiety that selectively binds to the antibody, forming a peptide-antibody complex and removing the complex from the serum sample. These steps may be repeated as many times as needed to reduce the humanized or chimeric monoclonal antibody to the desired level. | 03-22-2012 |
20120149126 | Fluidics Apparatus and Fluidics Substrate - A fluidics apparatus is disclosed for manipulation of at least one fluid sample, typically in the form of a droplet. The apparatus has a substrate surface with a sample manipulation zone for location of the fluid sample. A transducer arrangement such as an interdigitated electrode structure on a piezoelectric body provides surface acoustic waves at the substrate surface for manipulation of the fluid sample. The substrate surface has an arrangement of surface acoustic wave scattering elements forming a phononic crystal structure for affecting the transmission, distribution and/or behaviour of surface acoustic waves at the substrate surface. Also disclosed is a method for lysing a cell. In this method, the cell is comprised in a fluid sample contacting a substrate surface, the method comprising providing surface acoustic waves at the substrate surface, such that the cell lyses. | 06-14-2012 |
20120164747 | METHOD OF EXTRACTING PLASMA BY AGGLUTINATION OF BLOOD CELLS AND PLASMA SEPARATION DEVICE THEREFOR - The present invention relates to a plasma extraction method in which a complex of a blood cell-specific antibody and a protein having the ability to bind to the Fc region of the antibody is used to induce the agglutination of blood cells in blood, thereby increasing plasma separation efficiency, and to a plasma separation device therefor. According to the method, plasma can be separated from whole blood in high efficiency, and rapid plasma separation is possible, so that rapid diagnosis can be performed even with a small amount of blood. | 06-28-2012 |
20120264229 | COLLECTION DEVICE WITH DOUBLE OUTPUTS AND METHOD OF USING THE SAME - A collection device with double outputs and a method of using the same are provided. The collection device comprises an accommodating chamber comprising an upper chamber opening, a lower chamber opening and a chamber body therebetween; an inlet member comprising an upper inlet opening, a lower inlet opening and an inlet passage therebetween, said lower inlet opening being connected and communicated with said upper chamber opening; an outlet member comprising an outlet body, a protrusion depending from a lower surface of said outlet body, a first output positioned at a lower end of said protrusion and a second output provided at said lower surface of said outlet body, said lower chamber opening of said accommodating chamber being connected and communicated with said outlet member; a collecting section comprising a handle detachably engageable with said inlet member and a collecting stick attached to the handle, a lower portion of said collecting stick entering into said accommodating chamber through said inlet passage upon engagement of said handle with said inlet member, and a sealing assembly for sealing said first output and said second output. | 10-18-2012 |
20120288957 | REMOVAL OF PCR INHIBITORS - Provided herein is technology relating to processing and preparing samples and particularly, but not exclusively, to methods, systems, and kits for removing assay inhibitors from samples comprising nucleic acids. | 11-15-2012 |
20130078735 | METHOD FOR PREPARING A SAMPLE FOR CHROMATOGRAPHIC SEPARATION PROCESSES AND SYSTEMS FOR CARRYING OUT A SAMPLE PREPARATION - The invention relates to a method for preparing a sample for chromatographic separation processes, in which a sample vessel ( | 03-28-2013 |
20130102089 | Method For Processing A Sensor Chip - The method for processing a sensor chip in accordance with the present invention has: 1) providing an acoustic wave operation system and a biochemical sensor chip, wherein the acoustic wave operation system has a piezoelectric transducer generating at least one cycle of longitudinal acoustic waves by a driving voltage and wherein a probe is immobilized on a surface of the biochemical sensor chip; 2) arranging the piezoelectric transducer at a distance from the biochemical sensor chip and filling therebetween with a medium for transmitting longitudinal acoustic waves; and 3) applying longitudinal acoustic waves to the biochemical sensor chip to remove an adsorbate bound to the probe. | 04-25-2013 |
20130149790 | Sample preparation system for an analytical system for determining a measured variable of a liquid sample - A sample preparation system for an analytical system for determining a measured variable of a sample liquid, comprising: a transport unit connected with a sample taking location via a first fluid conducting line; a sample collecting unit, which serves the analytical system as a staging area for automated removal of liquid samples, based on which the measured variable is determined; a filter unit arranged between the sample taking location and the transport unit; and at least one reservoir connected via a second fluid conducting line with the filter unit for providing a cleaning medium for cleaning the filter unit; wherein the transport unit is embodied to transport sample liquid from the sample taking location through the filter unit into the sample collecting unit. The cleaning medium includes an oxidizing agent. | 06-13-2013 |
20140363896 | AUTOMATIC ANALYZER AND METHOD FOR WASHING SAMPLE-PIPETTING PROBE - When the type is to be changed from serum (preceding sample) to urine (current sample), “serum” is set to a preceding type and “urine” is set to a measurement type at number | 12-11-2014 |
20140377880 | SYSTEMS AND METHODS FOR PREPARING SAMPLES FOR CHEMICAL ANALYSIS USING A COOLED DIGESTION ZONE - An apparatus for preparing samples for chemical analysis includes a container receptacle for receiving a sample container having a crucible portion and an expansion portion. The container receptacle includes a heating compartment and a cooling compartment spaced apart from the heating compartment. The heating compartment is shaped to receive the crucible portion of the sample container, and the cooling compartment is shaped to receive the expansion portion of the sample container. The apparatus also includes a heating mechanism for heating the sample within the crucible portion of the sample container, a first cooling mechanism for cooling the expansion portion of the sample container, and a second cooling mechanism for cooling the crucible portion of the sample container. | 12-25-2014 |
20150056715 | METHOD AND SYSTEM FOR ACOUSTICALLY TREATING MATERIAL - Methods and systems for acoustically treating material using an acoustic energy system having a movable outer surface that contacts a sample holder. The outer surface may be cylindrical and rotate about a central axis, e.g., so that a sample holder may be driven to move by the outer surface. Acoustic energy may be emitted from within the outer surface to a treatment area outside of, and near, the outer surface. Thus, a sample holder in contact with the outer surface may have a sample exposed to acoustic energy while rotation of the outer surface may move the sample holder relative to treatment area. One or more additional rollers or other components may bias the sample holder into contact with the outer surface, to e.g., so the sample holder is squeezed between the outer surface and a roller or other biasing component. | 02-26-2015 |
20160144362 | PROXIMAL DEGAS DRIVEN MICROFLUIDIC ACTUATION - An apparatus with a self-contained, tunable, microfluidic pumping system that utilizes the high air permeability of the matrix material to actuate fluid flow in a network of fluidic microchannels and microstructures is provided. The pumping relies upon partial evacuation of degas/vacuum channels that are located next to the fluid channels to degas air from the fluid channels or structures producing a reduction of pressure in the fluidic channel leading to the flow of fluid from an inlet at atmospheric pressure through the device. The solution is isolated from the pumping apparatus since the liquid does not pass through the diffusion barriers. The apparatus and method can also provide bubble-free microfluidic pumping, without any auxiliary equipment or device pre-treatment, and can fill dead-end channels and chambers, providing a powerful liquid handling tool for a broad range of applications. | 05-26-2016 |