Entries |
Document | Title | Date |
20080241956 | METHOD FOR DETECTING ANALYTE AND BIOCHIP - A method for detecting an analyte in a sample liquid, using a detection reagent which reacts specifically with the analyte to give structural information on the analyte, comprising the steps of:
| 10-02-2008 |
20080261325 | Method and Device for Dispensing Dry Powders - The inventive method for dispersing a dry powder sample ( | 10-23-2008 |
20080261326 | Drop-on-demand manufacturing of diagnostic test strips - A drop-on-demand system for manufacturing diagnostic test strips includes a drop-on-demand mechanism, and a drop volume feedback subsystem and/or a vision subsystem. The drop-on-demand mechanism dispenses one or more reagents on the diagnostic test strips in one or more desired volumes and at one or more desired locations. The drop volume feedback subsystem control volumes of the reagents dispensed by the drop-on-demand mechanism so that the drop-on-demand mechanism dispenses the reagents on the diagnostic test strips in the desired volumes. The vision subsystem aligns the drop-on-demand mechanism in relation to the diagnostic test strips so that the drop-on-demand mechanism dispenses the reagents on the diagnostic test strips at the desired locations. | 10-23-2008 |
20080293156 | DEVICES AND METHODS FOR DISPENSING REAGENTS INTO SAMPLES - Devices and methods of dispensing and mixing reagents with samples in an enclosed container in which the amounts of the reagents dispensed into the sample are predetermined. The devices include dispensing covers attached to a funnel that feeds into a sample chamber. The dispensing covers may contain off-axis dispensing chambers that are sealed and that can be opened and any reagent(s) located therein dispensed into the at selected times. The off-axis dispensing chambers are preferably offset from a main axis of the device, such that the reagents dispensed from the dispensing chambers fall, under the force of gravity, onto the funnel wall and are then directed into the sample chamber. | 11-27-2008 |
20080293157 | Apparatus and method of performing high-throughput cell-culture studies on biomaterials - In one embodiment, a kit includes a base and a specimen removably couplable to the base. A top plate defines a plurality of apertures and is removably couplable to the base such that at least two of the apertures are associated with a specimen and each aperture defines a well with that specimen. Each well is configured to receive a sample material therein in contact with the specimen. A method includes disposing a specimen within a recessed portion of a test apparatus and coupling a top plate of the test apparatus to a base of the test apparatus such that a sealing engagement is formed between the top plate and the specimen. The top plate defines a plurality of apertures, each of at least two of the apertures collectively with the specimen defines a well. A sample material can be disposed within at least one well. | 11-27-2008 |
20080293158 | Method And Apparatus For Improved Gas Detection - The invention relates to a method and apparatus for providing a reactor having a heater, a passage for transporting a reactant, and a chamber containing a gas sample and being coupled to the passage for receiving the reactant and mixing the reactant with the gas sample. The reactor further includes a connector leading from the chamber to the heater for transporting a mixture of the reactant and gas sample, and wherein the heater heats the mixture of the reactant and gas sample. | 11-27-2008 |
20090004754 | MULTI-WELL RESERVOIR PLATE AND METHODS OF USING SAME - The present disclosure generally relates to a multi-well reservoir plate and methods of using the same. The multi-well reservoir plate includes a frame portion coupled to a plate portion, where a number of receptacles are formed in the plate portion. The receptacles or wells are sized to receive and support a substance without permitting the substance to leak or discharge from a passage formed in a lower portion of the well and in fluid communication with an upper portion of the well where the substances is supported. In one embodiment, the wells are at least partially filled with a substance, the substance is supported the in the wells for an amount of time, and then the substance is discharged from the wells by applying a force to the substance. By way of example, the force may be a pressure applied to an upper surface of the substance, a pressure (e.g., vacuum) applied to a lower surface of the substance, and/or an inertial force generated by an acceleration of the substance. | 01-01-2009 |
20090042313 | Recording assay device - The invention herein described relates to an assessment device comprising an assay part and a detachable recording part. The assessment device facilitates the rapid assaying and processing of tissue/fluid samples by healthcare workers. Also, advantageously, the result of the assay is only apparent to the healthcare worker after interrogation of the recording part at a processing facility. | 02-12-2009 |
20090093064 | METHOD OF DETERMINING THE PRESENCE OF A MINERAL WITHIN A MATERIAL - An improved flow-through device is provided wherein foam produced by the pumping of fluid in the device is kept outside the reaction chambers by way of a hydrophobic or hydrophilic porous membrane acting as an air trap membrane. | 04-09-2009 |
20090155925 | MICROFLUIDIC ELEMENT FOR THOROUGHLY MIXING A LIQUID WITH A REAGENT - A microfluidic element for thoroughly mixing a liquid with a reagent used for the analysis of the liquid for an analyte contained therein and a method thereof are disclosed. The microfluidic element has a substrate and a channel structure. The channel structure includes an elongate mixing channel and an output channel. The mixing channel has an inlet opening and an outlet opening, and is implemented to mix the reagent contained therein with the liquid flowing through the inlet opening into the mixing channel. The outlet opening of the mixing channel is in fluid communication to the output channel. The outlet opening is positioned closer to the middle of the length of the mixing channel than the inlet opening. | 06-18-2009 |
20090176314 | REAGENT CARTRIDGE - A reagent cartridge which can be exchangeably inserted into an analyzer and having a plurality of reagent bags furnished with connecting lines, each of which may optionally be connected to an input device of the analyzer, and method for operating the analyzer are disclosed. Each reagent bag has an analyzer-controlled multi-way valve with at least two valve positions at the point where the respective connecting line departs, such that the first valve position opens a fluid path between the connecting line and the reagent bag, while the second valve position closes off the reagent bag and opens a fluid path between a ventilation source, e.g. ambient air, and the connecting line. The connecting lines of the reagent bags departing from the multi-way valve open directly into a common rail or a collector valve. | 07-09-2009 |
20090209043 | DEVICE AND METHOD FOR HOLDING A CASSETTE FOR LABORATORY SAMPLES | 08-20-2009 |
20090209044 | Fluid Sample Collection System and Method - A fluid sample collection system includes a vial, a plunger and a fluid sample collection device having an absorbent for absorbing and retaining a fluid sample therein. The plunger includes an elongated handle portion and a plunger head portion detachably connected to the handle portion. The plunger also includes a splash guard supported on the handle portion. During the sample collection process, the saturated absorbent from the sample collection device is placed into the vial and the plunger is then advanced toward a closed end of the vial to express the fluid sample from the absorbent. The plunger head portion is retained within the vial with the absorbent in a generally compressed state and the handle portion is detached and removed from the vial. | 08-20-2009 |
20090215192 | Solid-phase affinity-based method for preparing and manipulating an analyte-containing solution - A method for preparing an analyte-containing solution, which is compatible with surface-tension-directed liquid droplet manipulation and solid-phase affinity-based assays, is disclosed. The method comprises providing an affinity capture surface comprising a substrate surface having a plurality of first and second surface modifiers associated therewith, wherein the first and second surface modifiers render the affinity capture surface wettable and resistant to non-specific protein adsorption, and wherein the second surface modifiers are capable of selectively retaining an analyte, contacting the affinity capture surface with the analyte to form analyte/surface modifier complexes between the analyte and the second surface modifiers, and cleaving the first and second surface modifiers to release terminal portions of the first and second surface modifiers and the analyte into a solution in contact with the affinity capture surface, thereby yielding the analyte-containing solution and generating a hydrophobic surface. Novel affinity capture surfaces and methods for preparing the same are also disclosed. | 08-27-2009 |
20090215193 | Application of a reagent to a matrix material - A reagent or particles having reagent supported thereon are applied to a matrix material by a contact printing process for example in which the matrix material is brought into contact with a rotating contact roll having the reagent or particles having reagent supported thereon disposed thereon so as to transfer the reagent or particles having reagent supported thereon to the matrix material. Such a contact printing processes allow high speed and high volume production of an assay device. | 08-27-2009 |
20090215194 | ASSEMBLY OF A MICROFLUIDIC DEVICE FOR ANALYSIS OF BIOLOGICAL MATERIAL - In a microfluidic assembly, a microfluidic device is provided with a body in which at least a first inlet for loading a fluid for analysis, and a buried area in fluid communication with the first inlet are defined. An analysis chamber is in fluid communication with the buried area and an interface cover is coupled in a fluid-tight manner above the microfluidic device. The interface cover is provided with a sealing portion in correspondence to the analysis chamber, operable to assume a first configuration, in which it leaves the analysis chamber open, and a second configuration, in which it closes the analysis chamber in a fluid-tight manner. | 08-27-2009 |
20090221090 | SAMPLE ANALYSIS APPARATUS, SAMPLE ANALYSIS METHOD, AND COMPUTER PROGRAM PRODUCT - A sample analysis apparatus for analyzing a measurement sample prepared by mixing a sample and a reagent includes a condition memory for storing information regarding a plurality of read conditions; an ID acquirer for reading out identification information at a predetermined position in accordance with a predetermined read condition, the identification information being assigned for identification of at least one of a sample container, a reagent container, and a holding section for holding the sample container or the reagent container; an ID acquisition checker for determining whether or not the ID acquirer has successfully read out the identification information; and a read condition changer for changing the predetermined read condition to a different read condition different from the predetermined read condition stored in the condition memory when the ID acquisition checker has determined that the readout operation was not successful. | 09-03-2009 |
20090221091 | CHEMICAL REACTION CARTRIDGE, MIXTURE GENERATING METHOD AND CONTROL DEVICE OF CHEMICAL REACTION CARTRIDGE - Disclosed is a chemical reaction cartridge including an elastic body as a construction material and a flow path and two or more chambers connected by the flow path formed inside the cartridge, and the cartridge is structured so as to move or block a fluid substance in the flow path or the chambers by partially sealing the flow path, the chambers or both the flow path and the chambers by applying external force to the elastic body from outside, as the chambers, the cartridge has two or more mixing chambers each of which is to contain a mixture in a fluid state and the cartridge has two or more ingredient chambers provided for each of the mixing chambers by being connected with the flow path, in each of which an ingredient of the mixture divided in an amount according to a mixing ratio is to be contained. | 09-03-2009 |
20090233378 | Method of Reaction in Flow Channel of Microchip and Analysis Device - In case of performing a reaction between reacting material and reagent by bringing the reagent in contact with the reacting material through flowing the reagent into a reaction flow channel in which the reaction material which reacts with the reagent is carried on a wall surface of the reaction flow channel of a microchip, the reaction is expedited efficiently by passing the reagent to the reacting material. The reagent | 09-17-2009 |
20090253215 | METHOD FOR CONTROLLING THE FLOW OF LIQUIDS CONTAINING BIOLOGICAL MATERIAL BY INDUCING ELECTRO- OR MAGNETO-RHEOLOGICAL EFFECT - The invention provides a method for controlling or manipulating the flow of a solution or liquid comprising biological material or biomolecules. Therefore, particles are added to the solution or liquid for providing the solution or liquid with rheological properties. The solution or liquid comprising the particles is provided in a microchannel and by applying an electric and/or magnetic field to the microchannel, the flow of the liquid or solution can be controlled. | 10-08-2009 |
20090286326 | Tool for Extracting Electrophoretic Sample - A gel extraction device ( | 11-19-2009 |
20090286327 | MICROFLUIDIC DEVICE CONTAINING LYOPHILIZED REAGENT THEREIN AND ANALYZING METHOD USING THE SAME - Provided is a microfluidic device suitable for analyzing a liquid sample. The device includes a first chamber to contain a sample; a second chamber to contain a liquid first reagent; a third chamber containing a lyophilized second reagent; a plurality of channels connecting the first, second, and third chambers. | 11-19-2009 |
20090305431 | FLUID TRANSFER MECHANISM - A microfluidic device for transferring liquid from a first chamber to a second chamber is provided. The device has a first chamber; a second chamber; and a barrier between the first chamber and the second chamber, the barrier having least one opening fluidly connecting the first chamber to the second chamber, the at least one opening being sized such that a retention force, such as surface tension, keeps the liquid in the first chamber. The fluid is transferred from the first chamber to the second chamber when an initiation input such as fluid pressure is introduced to the liquid that is sufficient to overcome the retention force. The device may be a sensor strip. | 12-10-2009 |
20100041164 | Mechanical device for mixing a fluid sample with a treatment solution - A method of preparing a fluid sample for use in a fluid analyte monitor, the method including drawing a fluid sample into a capillary channel in a body having a septum piercing projection; piercing a first septum covering a treatment solution chamber with the septum piercing projection, thereby exposing the fluid sample in the capillary channel to the contents of the treatment solution chamber; mixing the fluid sample with the contents of the treatment solution chamber; and piercing a second septum covering the treatment solution channel such that the mixed fluid and treatment solution chamber contents are received into a fluid analyte meter. The method may also include shaking the treatment solution chamber with the capillary channel therein, thereby mixing the fluid sample with the contents of the treatment solution chamber. | 02-18-2010 |
20100099199 | METHOD AND APPARATUS FOR ASCERTAINING REAGENT QUALITY - A method for determining reagent quality in a device having multiple treatment stations for the treatment of at least one of cytological and histological prepared specimens and an apparatus for performing this method are described. The method comprises providing a carrier element that comprises at least one test material; transferring and treating the carrier element having test material according to a predefined sequence in a plurality of the treatment stations together with the specimens; and evaluating the test material by means of an evaluation device after treatment in the last treatment station in sequence. The described method and apparatus achieve that reagent quality can be determined automatically and the reagents can be replaced at an optimum point in time. | 04-22-2010 |
20100112717 | Method for Providing a Dried Reagent in a Microfluidic System and Microfluidic System - A method for providing a dried reagent in a microfluidic system is provided, the method comprising the following steps: providing a microfluidic system having a microfluidic structure, introducing a flowable carrier medium containing a reagent in the microfluidic structure, and drying the reagent in the microfluidic structure by lyophilization. | 05-06-2010 |
20100112718 | Device For Receiving A Liquid And Also Device For Applying Liquids On Sample Carriers And Method For This Purpose - Methods and apparatus providing for receiving liquids and for applying liquids on sample carriers. | 05-06-2010 |
20100120166 | SUBSTRATE HAVING CHANNEL PORTION INCLUDING CHAMBERS, AND METHOD OF TRANSFERRING LIQUID BY USING THE SUBSTRATE - A substrate having a channel portion in which a liquid transfers, wherein, even if the channel portion has no micro-channel interconnecting chambers, a liquid can transfer stepwise from one region to the next region according to the speed of rotation of the substrate. The substrate can be rotated about a rotation axis as the center, and has the channel portion including the chambers formed therein. The inner wall of each chamber has a first area including an area intersecting with a centrifugal direction from the center; and also has a second area placed at a position farther from the center than the first area, and including a surface intersecting with the centrifugal direction from the center. Further, the first area has a region for holding a droplet of a liquid provided; and also has a region where a contact with the droplet expands when the substrate is rotated, and that communicate with the second area. | 05-13-2010 |
20100144054 | REACTOR PLATE AND REACTION PROCESSING METHOD - Disclosed herein is a reactor plate which prevents the entry of foreign matter from outside and the pollution of an outside environment. The reactor plate includes a sealed reaction well ( | 06-10-2010 |
20100167414 | SELF-SEALING MICROREACTOR AND METHOD FOR CARRYING OUT A REACTION - A microreactor includes a shell structure ( | 07-01-2010 |
20100167415 | ALIQUOTTING DEVICE - Aliquotting device on the basis of a micro litre test tube ( | 07-01-2010 |
20100190263 | Bubble Techniques for a Droplet Actuator - The present invention is directed to a droplet actuator and methods of making and using the droplet actuator including one or more substrates configured to form a droplet operations gap and including a physical or chemical feature that may be provided at a predetermined locus within or exposed to the droplet operations gap and configured to retain a bubble in position within the droplet operations gap. | 07-29-2010 |
20100261290 | Method of reaction in flow channel of microchip and analysis device - In the case of passing a reagent in a reaction channel in a microchip, which carries a reactant capable of reacting with the reagent on the wall thereof, and bringing the reactant into contact with the reagent so as to carry out a reaction, the reagent is efficiently passed to the reactant to thereby promote the progress of the reaction. In carrying out the reaction as described above, the reagent ( | 10-14-2010 |
20100273273 | Sampling single phase from multiphase fluid - A sampler ( | 10-28-2010 |
20100279429 | Method and Apparatus for Increasing the Sensitivity of a Biosensor Used in a Planar Waveguide - Systems, methods and apparatus are provided for mixing an analyte in a planar waveguide cartridge. The invention includes adding magnetic particles to an analyte containing one or more types of target molecules; inserting the analyte and magnetic particles into the cartridge; and moving a magnetic filed proximate to and around the cartridge containing the analyte and magnetic particles, wherein the movement of the magnet field causes movement in the analyte. | 11-04-2010 |
20100279430 | SAMPLE PREPARATION DEVICE AND METHOD - A sample preparation device for reducing a concentration of one or more concomitant components of a sample and/or increasing a concentration of one or more desired sample components is described. | 11-04-2010 |
20110008907 | SYSTEM USING SELF-CONTAINED PROCESSING MODULE FOR DETECTING NUCLEIC ACIDS - A method and apparatus are provided for processing a nucleic acid. The apparatus includes a disposable self-contained processing module that contains the nucleic acid and substantially all of the fluids to effect a nanoparticle hybridization test, a pump coupled to the processing module, a valving system disposed between the pump and processing module and a control system coupled to the pump and valving system causing the processing fluids to interact with the nucleic acid to effect a sandwich hybridization test using nanoparticles. | 01-13-2011 |
20110020947 | CHEMICAL COMPONENT AND PROCESSING DEVICE ASSEMBLY - A substantially dimensionally-stable chemical component is assembled with a sample processing device via a computer-controlled apparatus. In one embodiment, surface mount technology is used to assemble the chemical component with the processing device. The chemical component may include, for example, chemicals used for sample preparation or detection, such as a reagent. In different embodiments, the chemical component may be a tablet, microtablet, lyophilized pellet, bead, film, and so forth. In some embodiments, the chemical components are stored within a carrier that packages a plurality of chemical components. The carrier may define a plurality of pockets, where each pocket defines a discrete space for holding at least one chemical component. In some embodiments, a robotic arm aligns with a pocket in order to locate and remove a chemical component from the carrier and transfer the chemical component to a chamber of a processing device. | 01-27-2011 |
20110020948 | SPECIMEN PROCESSING APPARATUS AND CONTROL METHOD FOR THE SAME - A specimen processing apparatus comprising: a specimen processing section which includes a movable section and processes a specimen by moving the movable section; and a controller for determining whether the movable section was moved while a specimen processing operation by the specimen processing section was stopped, and controlling the specimen processing section to perform a preparing operation for starting the specimen processing operation based on the determination result, is disclosed. A control method for a specimen processing apparatus is also disclosed. | 01-27-2011 |
20110020949 | AUTOMATIC ANALYZER - In the field of automatic analyzers, as items to be analyzed are increase, various reagents differing in such properties as liquid viscosity and contact angle are being used more frequently, and this trend is expected to continue. Also, reagents now take various forms (e.g., a concentrated reagent to be diluted by the water of an automatic analyzer), and so does dilution water. Such being the case, the invention provides an automatic analyzer capable of sufficient stirring regardless of items to be analyzed. To sufficiently stir a substance to which a reagent has been added, the automatic analyzer is designed to alter stirring conditions after a given amount of time has passed since the addition of that reagent. | 01-27-2011 |
20110027902 | STRUCTURE FOR INTRODUCING A PLURALITY OF SOLUTIONS, MICRO FLUIDIC DEVICE HAVING SAID STRUCTURE AND METHOD FOR INTRODUCING SOLUTION - The present invention relates to a structure (a solution introducing structure) for introducing a plurality of solutions (a sample and/or a reagent solution) in highly accurate volume, in high amount and simply, into a channel, in particular a channel of a micro fluidic device, a micro fluidic device having said structure, a method for introducing a solution using said device, a method for separation of a substance, and a method for separating a complex between an analyte or analogue thereof, and a substance binding to said analyte or analogue thereof (hereinafter may be abbreviated as a complex forming substance or CFS) which is obtained by reacting a plurality of solutions introduced by these, and said CFS or analogue not involved in formation of said complex, rapidly, simply and in high accuracy, along with a method for measuring an analyte or an analogue thereof in a sample in high sensitivity. | 02-03-2011 |
20110027903 | FECAL SAMPLING DEVICE AND METHOD - A specimen sampling device having a first panel including multiple apertures (e.g., a first, second and third aperture) for receiving samples; a second panel having a removable tab at least partially aligned with the first, second and third apertures for receiving the samples, the removable tab accessible from an exterior of the device. A method of obtaining a fecal sample is also disclosed. | 02-03-2011 |
20110027904 | SAMPLE MIXING ON A MICROFLUIDIC DEVICE - Mixing structures for use on sample processing devices are disclosed. The mixing structures include one or more mixing chambers in fluid communication with a process chamber, such that changing the rotational speed of the sample processing device forces sample material into and out of the mixing chamber to achieve mixing of the sample material. The mixing chambers are in fluid communication with the process chambers through mixing ports that are located on the distal sides of the process chambers with respect to the axis about which the sample processing device is rotated. | 02-03-2011 |
20110039349 | SAMPLE TESTING APPARATUS, INFORMATION MANAGEMENT APPARATUS AND SAMPLE TESTING METHOD - A sample testing apparatus comprising: a receiving section which receives identification information inputted by an operator; a testing section which tests a sample to obtain a test result; a memory which stores the test result, which is obtained by the testing section, so as to be associated with the identification information received by the receiving section; and a controller, wherein the controller is configured to: make a display section display only the test result associated with the identification information corresponding to a first attribute in the test results stored in the memory when the identification information received by the receiving section corresponds to the first attribute; and make the display section display test results which are stored in the memory when the identification information received by the receiving section corresponds to the second attribute is disclosed. An information management apparatus and sample testing method are also disclosed. | 02-17-2011 |
20110039350 | HIGH YIELD ATMOSPHERIC PRESSURE ION SOURCE FOR ION SPECTROMETERS IN VACUUM - Gaseous analyte molecules are ionized at atmospheric pressure and provided to an inlet capillary of an ion spectrometer vacuum system by passing the ions through a reaction tube that ends in a conical intermediate piece for a gastight and smooth transition into the inlet capillary. The reaction tube is shaped so that the atmospheric pressure gas stream passing therethrough form the entrance of the tune to the intermediate piece is stably laminar. Analyte molecules from gas chromatographs, spray devices or vaporization devices can be introduced into the entrance of the reaction tube and ionized within the tube by single- or multi-photon ionization, by chemical ionization, by reactant ions or by physical ionization. For single- or multi-photon ionization, a beam from a laser can be passed axially down the reaction tube. Reactant ions can be produced by any means outside of the reaction tube and mixed with the analyte molecules within the tube. | 02-17-2011 |
20110059547 | USES OF REAGENTS IN SAMPLE COLLECTION AND CARTRIDGE SYSTEMS - Provided is a sample collection container comprising one or more reagent bodies, wherein each body comprises one or more reagents confined by a restraining agent, wherein the restraining agent is capable of being broken down to release the one or more reagents, and wherein the one or more reagents are dispersed through the restraining agent. | 03-10-2011 |
20110070655 | FLOW CELL AND LIQUID DELIVERY METHOD - A flow cell includes: a flow channel through which a sample solution flows; an inlet section which communicates with the flow channel and to which the sample solution is supplied; a transfer section which includes a plurality of opening sections, one end side of which communicates with the flow channel and an other side of which opens to outside air, and which communicates with the flow channel, and draws in and guides the sample solution supplied into the inlet section to the flow channel; a detecting section which faces the sample solution in the flow channel; and a sealing member which unsealably seals at least either one of the opening section or the inlet section. | 03-24-2011 |
20110076780 | SAMPLE PROCESSING APPARATUS, SAMPLE RACK TRANSPORTING METHOD, AND APPARATUS - A sample processing apparatus includes a sample processing unit for obtaining a sample from a sample container and performing a predetermined process of the sample; a transport unit which includes a transport region for transporting, in a transport operation, a sample rack holding the sample container to the sample processing unit, and a rack removal region where the sample rack is accessible to an operator. A restraining member is also provided, which restrains contact by the operator to the sample rack on the transport region. A transport controller controls the transport unit to transport the sample rack on the transport region to the rack removal region after a predetermined transport suspension event occurs during the transport operation. | 03-31-2011 |
20110086432 | DEVICE FOR MIXING A LIQUID SAMPLE - A device and a process for mixing a liquid sample in an automated analysis instrument comprises a support arm, a holder for a liquid container, a flexible intermediate element, arranged between the support arm and the holder for the liquid container, a shaking apparatus, and a coupling apparatus arranged on the holder for the liquid container, wherein the coupling apparatus can establish a detachable connection between the shaking apparatus and the holder for the liquid container. | 04-14-2011 |
20110091988 | SAMPLE PROCESSING UNIT AND SAMPLE PROCESSING METHOD - An example of the invention is a sample processing unit having, a subdivision/dispensing section including a nozzle needle configured to be able to penetrate a stopper body fitted in a sample container in which a sample can be contained, and configured to subject the sample container or the sample to processing, a detection unit configured to detect a state of the sample or the sample container at the time of the processing, and a label removal unit configured to remove at least part of a label attached to a side part of the sample container prior to the detection. | 04-21-2011 |
20110091989 | Method of Reducing Liquid Volume Surrounding Beads - The invention provides droplet actuators and droplet actuator techniques. Among other things, the droplet actuators and methods are useful for manipulating beads on a droplet actuator, such as conducting droplet operations using bead-containing droplets on a droplet actuator. For example, beads may be manipulated on a droplet actuator in the context of executing a sample preparation protocol and/or an assay protocol. An output of the methods of the invention may be beads prepared for execution of an assay protocol. Another output of the methods of the invention may be results of an assay protocol executed using beads. Among the methods described herein are methods of concentrating beads in droplets, methods of washing beads, methods of suspending beads, methods of separating beads, methods of localizing beads within a droplet, methods of forming emulsions in which droplets include beads, methods of loading beads into a droplet operations gap of a droplet actuator, methods of organizing beads in a monolayer, and methods of capturing, trapping or restraining beads. | 04-21-2011 |
20110104816 | Method of Loading a Droplet Actuator - The invention provides droplet actuators and droplet actuator cassettes including reagent storage capabilities, as well as methods of making and using the droplet actuators and cassettes. The invention also provides continuous flow channel elements and techniques for using electrodes to manipulate droplets in flowing streams. The invention also discloses methods of separating compounds on a droplet actuator. Various other aspects of the invention are also disclosed. | 05-05-2011 |
20110159606 | MICROPIPETTE, MICROPIPETTE SYSTEM, AND METHOD FOR USING MICROPIPETTE - There is provided a micropipette, a micropipette system, and a method for using a micropipette system capable of accurately sucking a desired quantitative volume of liquid for measurement. A micropipette system comprises a micropipette | 06-30-2011 |
20110183432 | TEST ELEMENT FOR ANALYZING AN ANALYTE PRESENT IN A SAMPLE OF A BODY FLUID, ANALYSIS SYSTEM AND METHOD FOR CONTROLLING THE MOVEMENT OF A FLUID CONTAINED IN A CHANNEL OF A TEST ELEMENT - Embodiments disclosed herein include an analysis system for the analysis of a body fluid sample for an analyte contained therein, comprising a test element and an evaluation device having a measuring station for measuring a measuring variable on the measuring zone of the test element. Also included is a mounting to hold a test element, the test element having an airflow channel with two expansion sections and a narrow section located between these expansion sections. The expansion sections may have a cross-sectional area that increases in comparison to the narrow section in the direction away therefrom. A connection channel is located between the narrow section and the analysis function channel such that an air exchange connection is formed. The airflow channel is located in such a manner that a partial vacuum, which is generated using an airflow flowing through the airflow channel, acts on the analysis function channel. | 07-28-2011 |
20110195517 | MICRO TITRE PLATE - A micro titre plate comprising a number of wells filled with separation matrix. According to the invention the volume of the separation matrix is varied between at least some of the wells. | 08-11-2011 |
20110212539 | EXTRACTION SYSTEM - An extraction system for distributing a test product in an extraction fluid, the system including a flow cell and a pump The flow cell has walls defining an internal passageway having an extraction region for holding the test product and also an upstream end and a downstream end between which the extraction region extends. The internal cross-sectional area of the upstream end is larger than the internal cross-sectional area of the downstream end the and extraction region tapers from the upstream end to the downstream end. The pump has an inlet in fluid communication with the downstream end and an outlet in fluid communication with the upstream end. The pump re-circulates extraction fluid from the downstream end back to the upstream end so as to progressively erode the test product and distribute the test product in the extraction fluid. | 09-01-2011 |
20110229978 | IN SITU HEAT INDUCED ANTIGEN RECOVERY AND STAINING APPARATUS AND METHOD - Contemplated herein is an automated microscope slide antigen recovery and staining apparatus and method that features a plurality of individually operable miniaturized pressurizable reaction compartments for individually and independently processing a plurality of individual microscope slides. The apparatus preferably features independently movable slide support elements each having an individually heatable heating plate. Each slide support element preferably supports a single microscope slide. Each microscope slide can be enclosed within an individual pressurizable reaction compartment. Pressures exceeding 1 atm or below 1 atm can be created and maintained in the reaction compartment prior to, during or after heating of the slide begins. Because of the ability to pressurize and regulate pressure within the reaction compartment, and to individually heat each slide, each slide and a liquid solution or reagent thereon can be heated to temperatures that could not be obtained without the enclosed pressurized environment of the reaction compartment. A reagent dispensing strip having a plurality of reconfigurable reagent modules may also be used. | 09-22-2011 |
20110263038 | PUNCH SAMPLING APPARATUS AND METHOD - A punching apparatus ( | 10-27-2011 |
20110263039 | LIQUID CONTAINER WITH VARIABLE EXTRACTION CHIMNEY - A liquid container having a top opening, a base, and an extraction chimney which extends into the container and which is in alignment with the top opening is presented. The extraction chimney is intended for the withdrawal of liquid by a liquid-withdrawal element that is introduced into the liquid container through the extraction chimney. The extraction chimney has a liquid-permeable zone in its bottom region, adjacent to the liquid container base. The liquid permeability of the liquid-permeable zone of the extraction chimney can be adjusted between a setting for minimal liquid permeability and a setting for greater liquid permeability. The extraction chimney can be adjusted while the extraction chimney remains in the liquid container. | 10-27-2011 |
20110281372 | DETECTION SYSTEMS - An IMS system or the like has dopant contained in a way such that it is only released when needed. The dopant could be contained in a device ( | 11-17-2011 |
20110287555 | REUSABLE SHEATHS FOR SEPARATING MAGNETIC PARTICLES - An assembly that utilizes reusable sheaths for covering magnetic rods for collecting particles in an inverse magnetic particle process. The magnetic rod is removed from the reusable sheath to release particles at the same or a different location. The reusable sheaths can be assembled in a cylindrical plate, which can be rotated to position a clean sheath for each step of the inverse magnetic particle process. When not being used for particle separation, the sheaths can be washed of potentially contaminating solution in wash receptacles. | 11-24-2011 |
20110318845 | SAMPLE ANALYZER AND LIQUID ASPIRATING METHOD - A sample analyzer is configured to execute a liquid surface detection of detecting a liquid surface in a container by a liquid surface detector prior to a lowering operation of an aspirating tube for aspirating the liquid if a liquid level information is not stored in a memory, and store a liquid level information of a container in the memory based on a detection result by the liquid surface detection. Also, a liquid aspirating method by a sample analyzer. | 12-29-2011 |
20120034703 | Devices, Systems and Methods for Processing of Magnetic Particles - Devices, systems and methods for separation of magnetic particles with either hand held devices or automated instruments. Specifically, the production of magnetic fields for the separation of the particles within containers such as microtiter plates with a magnetic field that is substantially consistent for each well. Certain embodiments produce a magnetic field that is substantially uniform across each well bottom, while other embodiments produce a magnetic field that is stronger toward the outer region of each well. | 02-09-2012 |
20120058570 | IN SITU HEAT INDUCED ANTIGEN RECOVERY AND STAINING METHOD - An automated in situ heat induced antigen recovery and staining method and apparatus for treating a plurality of microscope slides. The process of heat induced antigen recovery and the process of staining the biological sample on the microscope slide are conducted in the same apparatus, wherein the microscope slides do not need to be physically removed from one apparatus to another. The reaction conditions for treating a slide can preferably be controlled independently, including the individualized application of reagents to each slide and the individualized treatment of each slide. | 03-08-2012 |
20120077283 | METHOD AND APPARATUS FOR FRAGMENTING NUCLEIC ACIDS - Systems and methods include processing devices used to fragment nucleic acids to average nucleic acid sizes ranging from between about 5 kbp and about 20 kbp. A processing device may include an inlet portion and a channel upstream from a shearing region arranged so that a relatively constant pressure is established and maintained (e.g., a pressure that changes by less than about 40%) at an entrance of the shearing region during a majority of sample flow through the shearing region. In some embodiments, after forcing the sample through the shearing region once, the processing device may be taken out of the centrifuge, inverted and placed back into the centrifuge so that the sample is forced through the shearing region again. | 03-29-2012 |
20120083045 | SURFACE SAMPLING CONCENTRATION AND REACTION PROBE - A method of analyzing a chemical composition of a specimen is described. The method can include providing a probe comprising an outer capillary tube and an inner capillary tube disposed co-axially within the outer capillary tube, where the inner and outer capillary tubes define a solvent capillary and a sampling capillary in fluid communication with one another at a distal end of the probe; contacting a target site on a surface of a specimen with a solvent in fluid communication with the probe; maintaining a plug volume proximate a solvent-specimen interface, wherein the plug volume is in fluid communication with the probe; draining plug sampling fluid from the plug volume through the sampling capillary; and analyzing a chemical composition of the plug sampling fluid with an analytical instrument. A system for performing the method is also described. | 04-05-2012 |
20120088309 | SYSTEMS AND METHODS FOR SAMPLE COLLECTION - A tube assembly, system and method for biological sample collection. In one embodiment, the tube assembly of the present disclosure includes a first tube, a second tube, a mechanism for securing the first and second tubes. The securing mechanism orients the first ends of the first and second tubes in a manner such that the first end of the second tube extends beyond the first end of the first tube to create an interstitial space between the outer diameter of the first tube and the inner diameter of the second tube, | 04-12-2012 |
20120088310 | DEVICE FOR CUTTING A SAMPLE CARRIER - A device for receiving a sample carrier is provided. The device includes an opening for receiving part of the sample carrier and a cutter for removing a part of the sample carrier. The cutter is coupled to a lid, which is movable to allow the cutter to make an incision in the sample carrier and, at the same time, to close at least part of the opening left open after receipt of the sample carrier. The disclosure further relates to a system comprising such a device and a method for operating such a device. | 04-12-2012 |
20120171777 | TAPERED CUVETTE AND METHOD OF COLLECTING MAGNETIC PARTICLES - A vessel for use in clinical analysis including an open top, a closed bottom, and at least four tapered sides. A method for collecting magnetic particles in a fluid comprising the steps of providing a magnet and a vessel containing magnetic particles in a fluid, attracting the magnetic particles to the magnet, and moving the magnetic particles with the magnet out of the fluid. | 07-05-2012 |
20120190126 | MICROFLUIDIC TRANSDUCER - Provided herein are apparatuses and methods for fragmenting nucleic acids or disrupting cells. For example, some embodiments provide a disposable microfluidic device designed to position a sample to be in direct contact with a high frequency vibrating element that emits an ultrasonic frequency into the sample such that the vibrational energy transduced into the sample results in fragmenting nucleic acids or disrupting cells. | 07-26-2012 |
20120190127 | SYSTEMS AND METHODS FOR DETERMINING PROCESS CONDITIONS IN CONFINED VOLUMES - Systems and methods for the determination of properties in confined (volumes are generally described. Generally, a gradient in at least one parameter (e.g., temperature) may be established across a plurality of confined volumes. In addition, at least one property (e.g., whether a crystal has been formed in the confined volume) of an interaction in at least one confined volume may be determined. In some embodiments, based upon the property determining step, a relationship between at least one parameter and at least one property may be determined. The confined volumes in which crystals may be contained may include, but are not limited to, droplets, microwells, and the like. | 07-26-2012 |
20120214254 | Microsystem for Fluidic Applications, and Production Method and Usage Method for a Microsystem for Fluidic Applications - A microsystem for fluidic applications includes a substrate with a reservoir, a first microchannel, connected to the reservoir, and a second microchannel, separated from the first microchannel by a web. The microsystem furthermore has an elastic film on the substrate, which film has a joint to the substrate around the reservoir and seals the reservoir. Here, the joint has a permanent joining area and, on the web, a web joining area that can be broken open and adjoins the permanent joining area at both ends of the web. Such a microsystem forms a processing chip with reagent receptacle. | 08-23-2012 |
20120220042 | EVIDENCE COLLECTOR WITH INTEGRAL QUANTIFIED REAGENTS AND METHOD OF MODULATING SPECIMEN DRYING TIME - Apparatus and methods are provided for evidence specimen collection having integral reagent holders to hold reagent vials and having drying agent or desiccant holding areas that permit the renewal of the desiccant and permit the introduction of variously size desiccant qualities to allow modulation of the specimen drying time to achieve early stabilization of specimens while holding the specimen in an isolated drying area during storage and shipment and for simultaneous collection of multiple evidence samples with simultaneous storage, drying, marking, evidence security and shipping provided and with the provision for simultaneous storage, drying, marking, evidence security and shipping provided for a control specimen. | 08-30-2012 |
20120220043 | EVIDENCE COLLECTOR WITH INTEGRAL QUANTIFIED REAGENTS AND METHOD OF MODULATING SPECIMEN DRYING TIME - Apparatus and methods are provided for evidence specimen collection having integral reagent holders to hold reagent vials and having drying agent or desiccant holding areas that permit the renewal of the desiccant and permit the introduction of variously size desiccant qualities to allow modulation of the specimen drying time to achieve early stabilization of specimens while holding the specimen in an isolated drying area during storage and shipment and for simultaneous collection of multiple evidence samples with simultaneous storage, drying, marking, evidence security and shipping provided and with the provision for simultaneous storage, drying, marking, evidence security and shipping provided for a control specimen. | 08-30-2012 |
20120220044 | Apparatus, System, and Method of Processing Biopsy Specimen - A biopsy pipette with a filter attached in an internal compartment of a pipette designed to prevent lodging and possible loss of the tissue specimen for analysis. A biopsy test tube may be provided with a biopsy bag attached in the internal compartment of the test tube. Further, a biopsy cassette may be provided with an opening configured to receive a pipette. An automated and non-automated system and method of using the biopsy pipette, biopsy test tube, and biopsy cassette in the processing of biopsy specimen is also disclosed. | 08-30-2012 |
20120220045 | Double Trench Well for Assay Procedures - Apparatuses, systems and methods for using assay preparation plates comprising wells with two trenches are presented. More specifically, well plates are presented that comprising an array of wells configured to retain a plurality of beads suspended in a fluid during an assay procedure, each well in the array comprising a first trench and a second trench, wherein the working volume of each well is between about 25 uL and about 10 mL. | 08-30-2012 |
20120238033 | FLUIDIC CONNECTORS AND MICROFLUIDIC SYSTEMS - Fluidic connectors, methods, and devices for performing analyses (e.g., immunoassays) in microfluidic systems are provided. In some embodiments, a fluidic connector having a fluid path is used to connect two independent channels formed in a substrate so as to allow fluid communication between the two independent channels. One or both of the independent channels may be pre-filled with reagents (e.g., antibody solutions, washing buffers and amplification reagents), which can be used to perform the analysis. These reagents may be stored in the channels of the substrate for long periods amounts of time (e.g., 1 year) prior to use. | 09-20-2012 |
20120252133 | TEST METER WITH A STRIP PORT CONNECTOR CONFIGURED FOR FLUID ENTRAPMENT - A test meter for use win an analytical test strip for the determination of an analyte (such as glucose) in a bodily fluid sample (e.g., a whole blood sample) includes a test meter housing and a strip port connector. The test meter housing has a distal end with a strip port opening configured to receive the analytical test strip. The strip port connector is integrated with the distal end of the test meter housing and has a distal portion with an analytical test strip guide. The analytical test strip guide has an upper guide surface configured such that an analytical test strip received in the strip port opening is guided and supported by the upper guide surface and also has a liquid entrapment feature configured to direct free liquid that enters the strip port opening away from the upper guide surface and entrap such directed liquid in the distal portion of the strip port connector and/or the distal end of the test meter housing. The strip port connector also has a proximal portion disposed within the test meter housing with the proximal portion having an electrical connector pin configured for operable electrical contact with an analytical test strip received within the strip port opening. | 10-04-2012 |
20120252134 | TEST TUBE FOR DIAGNOSTIC ANALYSES - A test tube ( | 10-04-2012 |
20120264228 | METHOD AND APPARATUS FOR FRAGMENTING DNA SEQUENCES - A method of fragmenting a DNA sequence having a starting size of at least 10000 base pair into fragments having a mean size smaller than or equal to 1300 bp, wherein the DNA sequence is put in a solution, the solution comprising the DNA sequence is put in a container and the container is placed in a liquid bath which is subjected to the action of ultrasound waves such that the ultrasound waves travel through the liquid bath to excite the container and the solution so as to shear the DNA sequence, and wherein the ultrasound waves have a frequency falling in the range between 28 kHz and 80 kHz. | 10-18-2012 |
20120288956 | COLLECTING AND PROCESSING COMPLEX MACROMOLECULAR MIXTURES - This document provides methods and materials involved in collecting and processing complex macromolecular mixtures (e.g., stool samples). For example, stool collection devices, buffers for stabilizing nucleic acid and polypeptides present in stool, and kits for using sequence-specific capture probes (e.g., nucleic acid sequences designed to hybridize with particular target nucleic acids) to capture target nucleic acids directly from complex macromolecular mixtures (e.g., stool samples) without the need to perform prior steps to enrich, isolate, or purify the nucleic acid component are provided. | 11-15-2012 |
20120309104 | Sample Processing Device, Sample Processing Method, and Reaction Container Used in These Device and Method - This invention concerns a sample processing device capable of efficiently recovering biological molecules, such as nucleic acids or proteins. The sample processing device is capable of placing a reaction container having a plurality of reaction sites, and it comprises a nozzle mechanism with a nozzle capable of attaching and removing a dispenser tip for dispensing a solution into the reaction sites of the reaction container and a magnetic tip for generating a magnetic field that allows magnetic beads to migrate to a space among the plurality of reaction sites in the reaction container, and a drive control unit controlling the nozzle mechanism. | 12-06-2012 |
20130071944 | SAMPLE PREPARATION DISPOSABLE DEVICES AND SAMPLE COLLECTION AND PREPARATION METHODS USING SAME - An article of manufacture embodiment comprises a sample cartridge including a sample substrate, and an enclosure including a sample ingress port. The enclosure mates with the sample cartridge to define a sample container containing the sample substrate which is accessible in the sample container via the sample ingress port. The sample cartridge including the sample substrate is removable from the sample container. A sampling method embodiment comprises disposing a sample on a sample substrate in a sample container and removing a sample cartridge including the sample substrate from the sample container. An article of manufacture embodiment comprises a sample substrate, a sample container containing the sample substrate and including a sample ingress port providing access to the sample substrate in the sample container, and a sample cartridge including the sample substrate. The sample cartridge including the sample substrate is removable as a unit from the sample container. | 03-21-2013 |
20130078733 | SYSTEMS AND METHODS FOR FLUID HANDLING - Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample. | 03-28-2013 |
20130078734 | MICROSCOPE SLIDE COVER WITH INTEGRATED RESERVOIR - A cover for a substrate including: a body defining a cavity, for positioning over the substrate to form a reaction chamber; and a projection extending from the body to define a fluid reservoir, when the cover is fitted to the substrate, the fluid reservoir being in fluid communication with the cavity. | 03-28-2013 |
20130084647 | DISPOSABLE FOIL PUNCH FOR IMMUNOHEMATOLOGY TEST ELEMENTS - Disclosed is a device and method of using the device to reduce false positives when using sealed packs in an immunodiagnostic analyzer while allowing use of the reagents in multiple tests as well as reuse of disposable punches employed for piercing foil covering the reagent aliquots. The disclosed devices and methods are useful in carrying out tests in immunohematology such as for a blood type or a screen. | 04-04-2013 |
20130115712 | INSTRUMENT FOR CASSETTE FOR SAMPLE PREPARATION - A parallel processing system for processing samples is described. In one embodiment, the parallel processing system includes an instrument interface parallel controller to control a tray motor driving system, a close-loop heater control and detection system, a magnetic particle transfer system, a reagent release system, a reagent pre-mix pumping system and a wash buffer pumping system. | 05-09-2013 |
20130143331 | COMPOSITIONS AND METHODS FOR PHOTOCONTROLLED HYBRIDIZATION AND DEHYBRIDIZATION OF A NUCLEIC ACID - Compositions and methods are provided that enable light-controlled hybridization between two nucleic acid sequences. | 06-06-2013 |
20130210163 | ANALYSIS - A method for collecting a sample and/or analysing a sample is provided, together with kits for use therein, in which the method includes using the kit and wherein an identifier is provided on one or more of the devices and/or containers and/or packaging which can be recorded and which is used to link the identity of the identifier for one or more of those identifiers to one or more of the identities for one or more of the other identifiers. In this way, the different devices, containers, pieces of equipment, reagents and stages used in the collection and/or analysis can be linked together for future reference. This ensures the correct processing of the sample and the correct attributing of the end results to it. Checks or other enquiries can be made on each of the different devices etc to validate the results if necessary. | 08-15-2013 |
20130217144 | Device and Method for Manipulating and Mixing Magnetic Particles in a Liquid Medium - A device for manipulating and mixing magnetic particles ( | 08-22-2013 |
20130230930 | TREATMENT OF A SAMPLE WITH FOCUSED ACOUSTIC ENERGY - A device for treating a sample with focused acoustic energy is provided. The device transmits the generated acoustic energy from the source to the sample via a complete dry propagation path. A cartridge containing the sample is inserted into an instrument, wherein the insertion forms a dry propagation path. | 09-05-2013 |
20130260474 | Microfluidic passive mixing chip - An improved device and method for passive mixing of fluids is described, and the use of the device in clinical diagnostic procedures. The mixer provides thorough mixing of a sample of blood or other fluid with an assay material, such as a diluent or a component of an assay system, in a closed system with a low and limited pressure drop. Sample size is small, typically 5 to 300 microliters. Mixing is accomplished by a combination of rotational vortex mixing due to a fluid stream coming tangent to a drain, and either or both of a second vortex mixer of opposite handedness, and a Dean mixer. Combinations of these techniques reliably provide complete mixing at low pressure drop. In a preferred usage, the microfluidic system can run a diluent continuously and inject samples at intervals, to facilitate automatic data processing of optical or other signatures of the well-mixed stream. | 10-03-2013 |
20130260475 | METHOD OF APPLYING A BIOLOGICAL SPECIMEN TO AN ANALYTIC PLATE - A method of applying a biological specimen to an analytic plate by using an applicator device to apply a coating to the analytic plate and adhering the biological sample to the plate. The coating is substantially transparent, translucent or invisible, and is substantially flush with the surface of the analytic plate. The coating is preferably comprised of a polysiloxane, siloxane, silicone, a silane, a silicon fluid, or a combination thereof and optionally an acid. | 10-03-2013 |
20130260476 | FECAL SAMPLING DEVICE AND METHOD - A collection device for use in connection with off-device testing of collected samples. The device includes a first panel having one or more apertures for receiving samples, a second panel opposite the first panel, and a removable tab having a first portion and a second portion. The first portion is aligned with at least one of apertures on the first panel and constructed such that depositing the sample through the at least one aperture causes the sample to be directly deposited on the first portion of the tab, and the second portion includes a sample-free grasping area accessible from an exterior of the device for removing the tab. A method of obtaining a sample is also disclosed. | 10-03-2013 |
20130260477 | BIOLOGICAL SAMPLE STORAGE DEVICE - Embodiments of the invention relate to methods of assembling an apparatus for holding biological samples. Conventionally, storage media are encased in a relatively thin flexible cardboard frame. Such constructions are vulnerable to damage from moisture and mechanical forces; these defects may subsequently cause problems for automated handling systems. In an embodiment, these defects are prevented by providing a pair of rigid frames, each frame comprising an aperture; placing a biological sample storage medium between the two frames so that the biological sample storage medium at least partly overlaps each of the apertures in the frames; and joining the two frames to fix the biological sample storage medium in place while allowing access to the biological sample storage medium via each of the apertures. Thus, in embodiments of the present invention, the frames can be rigid and waterproof, and provide a robust storage media for biological samples. At least one pre-defined area of weakness can be provided in the frames, to allow removal of a portion of the frames. | 10-03-2013 |
20130330833 | GRAPHENE OXIDE FILTERS AND METHODS OF USE - A system and device for filtering fluids using graphene oxide (GO) is provided. GO-based filters may be used for the efficient removal of microorganisms from organic and aqueous liquids and may be used to prevent fuel biodeterioration. Functionalization of graphene oxide with reactive oxygen functional groups provides physical properties to the GO including high solubility in polar solvents, good colloidal properties, low production costs, low toxicity, and a large surface area which can be decorated with antimicrobial agents including nanosilver. GO may be used as a filtration media for efficient removal of bacteria and to remove small amounts of water from hydrocarbon fuels. The GO filter media may be made of a plurality of GO particles, a structural core coated with GO, a non-porous structural membrane coated with GO, or a filtering membrane coated with GO. A method for sampling impurities found in an environmental sample is also provided. | 12-12-2013 |
20130344614 | Kit - A kit comprising a carrier and vessels arranged on the carrier, wherein different reagents are contained in different vessels, the vessels are arranged with an openable closing device on top of the carrier, the carrier has a footprint on the bottom side for being placed on a base, and the carrier has bottom positioning means for being positioned on at least one workplace of an automated laboratory system for microtiter plates according to the SBS standard. | 12-26-2013 |
20130344615 | FLUID SAMPLING APPARATUS AND COLLECTOR PAD SPLITTER - A fluid sampling apparatus having a container and a splitter disposed in the container. The splitter is operative for dividing an absorbent pad of a sample collector into two portions. The splitter may have a base and clamping arrangement connected to the base. The clamping arrangement is operative for clamping onto a first portion of the absorbent pad so that the first portion of the absorbent pad can be separated from a second portion of the absorbent pad by pulling the sample collector away from the splitter. | 12-26-2013 |
20130344616 | Device and a Method for Collecting and Transferring Samples of Biological Material - A device for collecting, transferring and/or conserving samples of biological material, comprising at least: a support body having at least a housing seating for a conserving element for samples, the housing seating being configured for enabling removably housing the conserving element for samples of biological material, the support body being configured for maintaining at least a conserving portion of the conserving element accessible for depositing a sample when the conserving element is housed in the housing seating; an operating portion, movable between a first closed position in which it is arranged in proximity of said housing seating and at least an open position in which it is arranged in a distanced position from the housing seating; and engaging portion configured for selectively and removably engaging a sampling element for samples, in particular an element for buccal sampling, to the support body and/or to the operating portion. | 12-26-2013 |
20140017804 | Container for Selective Transfer of Samples of Biological Material - A container for selective transport of samples of biological material or of biological origin comprising a body ( | 01-16-2014 |
20140024133 | METHOD FOR OPTIMIZING VERTICAL PROBE ALIGNMENT USING DIAGNOSTIC MIXING ROUTINES - A method and apparatus for adjusting the height of a tip of a mixing element, such as a needle probe, compares the mixing efficiency observed at two heights separated by a predetermined distance. The heights can be incrementally adjusted to determine the location of the bottom of a mixing vessel and, by extension, the approximate location for placing the mixing element for efficient mixing of solutions in the mixing vessel. | 01-23-2014 |
20140024134 | IN SITU HEAT INDUCED ANTIGEN RECOVERY AND STAINING APPARATUS AND METHOD - Contemplated herein is an automated microscope slide antigen recovery and staining apparatus and method that features a plurality of individually operable miniaturized pressurizable reaction compartments for individually and independently processing a plurality of individual microscope slides. The apparatus preferably features independently movable slide support elements each having an individually heatable heating plate. Each slide support element preferably supports a single microscope slide. Each microscope slide can be enclosed within an individual pressurizable reaction compartment. Pressures exceeding 1 atm or below 1 atm can be created and maintained in the reaction compartment prior to, during or after heating of the slide begins. Because of the ability to pressurize and regulate pressure within the reaction compartment, and to individually heat each slide, each slide and a liquid solution or reagent thereon can be heated to temperatures that could not be obtained without the enclosed pressurized environment of the reaction compartment. A reagent dispensing strip having a plurality of reconfigurable reagent modules may also be used. | 01-23-2014 |
20140030817 | METHOD AND APPARATUS FOR STORING AND DISPENSING REAGENT BEADS - Embodiments of the invention provide an efficient and effective technique for storing and dispensing reagent beads. In one embodiment, an apparatus is provided for dispensing reagent beads contained in a bead storage device which includes a bead carrier having a plurality of wells; a plurality of reagent beads disposed in the wells; and a cover tape releasably attached to the bead carrier to cover the wells and retain the reagent beads in the wells. The apparatus comprises a channel in which to place the bead storage device with the bead carrier facing a support wall of the channel and the cover tape facing a stripping wall of the channel. The stripping wall includes a stripping gap disposed between a stripping edge and an opposite edge, and a dispense opening provided adjacent the opposite edge on a side of the stripping wall opposite from the stripping edge. The cover tape is insertable through the stripping gap to be pulled against the stripping edge to peel the cover tape from the bead carrier to move the wells of the bead carrier inside the channel toward the dispense opening and expose the wells individually to dispense the reagent beads. | 01-30-2014 |
20140057363 | Method of Reducing Liquid Volume Surrounding Beads - The invention provides droplet actuators and droplet actuator techniques. Among other things, the droplet actuators and methods are useful for manipulating beads on a droplet actuator, such as conducting droplet operations using bead-containing droplets on a droplet actuator. For example, beads may be manipulated on a droplet actuator in the context of executing a sample preparation protocol and/or an assay protocol. An output of the methods of the invention may be beads prepared for execution of an assay protocol. Another output of the methods of the invention may be results of an assay protocol executed using beads. Among the methods described herein are methods of concentrating beads in droplets, methods of washing beads, methods of suspending beads, methods of separating beads, methods of localizing beads within a droplet, methods of forming emulsions in which droplets include beads, methods of loading beads into a droplet operations gap of a droplet actuator, methods of organizing beads in a monolayer, and methods of capturing, trapping or restraining beads. | 02-27-2014 |
20140106466 | GLASS BEAD FLOW RATES TO FACILITATE IMMUNODIAGNOSTIC TEST ELEMENT MANUFACTURE - A method of preparing a glass bead mixture using inert nanoparticles to improve flow rates of the glass beads for purposes of manufacturing an immunodiagnostic test element, such as a column agglutination test cassette, and a test element made in accordance with the method. | 04-17-2014 |
20140147930 | MICROFLUIDIC DEVICE WITH HOLDING INTERFACE, AND METHODS OF USE - Aspects of the present invention provide a freestanding microfluidic pipette with integrated wells for solution storage. Further aspects of the invention provide a holding interface to provide connectivity with external control components. One aspect of the invention provides a system for applying a microfluidic device in microscopy. The system includes: a microfluidic device having an elongated shape and defining one or more wells for solution storage and processing; and an interface adapted and configured to hold the microfluidic device in a freestanding manner and facilitate simultaneous connection of the one or more wells with a flow controller. Another aspect of the invention provides a method for utilizing a microfluidic device. The method includes: providing a device as described herein; positioning the device adjacent to a microscope; and actuating the interface to operate the microfluidic device. | 05-29-2014 |
20140147931 | VERSATILE DRUG TESTING DEVICE - A versatile drug testing device (a lateral flow diagnostic testing device) includes a flat transparent carrier with a top and a bottom with the carrier having a series of independent parallel grooves formed therein running from adjacent to the top to adjacent to the bottom of the carrier, each groove having a first opening and a second opening above the first opening therein adjacent to the bottom of the carrier, at least one drug test strip installed in one of said grooves with its absorbent pad contiguous to the openings and a cover layer attached to the carrier operable to sealing close each of said grooves whereby the bottom of the device can be immersed in a specimen of urine, body fluid, or other biological specimen to wet the pad of the at least one test strip though the ingress of the specimen though the associated openings and the test results on the test strip can be easily viewed through the transparent carrier. Because of the unique construction the device will give accurate reading if temporarily immersed in the specimen or left in the specimen for an extended period of time, making it very user friendly. | 05-29-2014 |
20140170764 | PRETREATMENT SYSTEM AND METHOD - The present invention is mainly intended to provide a pretreatment system that can use an calcium ion electrode to accurately measure calcium ion concentration with a simple configuration, and the pretreatment system is a pretreatment system | 06-19-2014 |
20140186969 | DINITROXIDE-TYPE BIRADICAL COMPOUNDS OPTIMIZED FOR DYNAMIC NUCLEAR POLARIZATION (DNP) - The present invention relates to the field of organic chemistry and in particular to organic free radicals used as polarizing agents in the technique of Dynamic Nuclear Polarization (DNP), which involves transferring the polarization of electron spins to the nuclei of a compound whose Nuclear Magnetic Resonance (NMR) is being observed. It concerns Dinitroxide-type Biradical polarizing agents characterized by a rigid linkage between the aminoxyl groups of said nitroxide units. This particular structure enables, at low temperatures and high fields, optimal transfer of polarization and optimal enhancement of NMR/MAS signals of the polarized nuclei of the compound studied. | 07-03-2014 |
20140199777 | GRAPHENE OXIDE FILTERS AND METHODS OF USE - A system and device for filtering fluids using graphene oxide (GO) is provided. GO-based filters may be used for the efficient removal of microorganisms from organic and aqueous liquids and may be used to prevent fuel biodeterioration. Functionalization of graphene oxide with reactive oxygen functional groups provides physical properties to the GO including high solubility in polar solvents, good colloidal properties, low production costs, low toxicity, and a large surface area which can be decorated with antimicrobial agents including nanosilver. GO may be used as a filtration media for efficient removal of bacteria and to remove small amounts of water from hydrocarbon fuels. The GO filter media may be made of a plurality of GO particles, a structural core coated with GO, a non-porous structural membrane coated with GO, or a filtering membrane coated with GO. A method for sampling impurities found in an environmental sample is also provided. | 07-17-2014 |
20140199778 | DEVICES TO DETECT A SUBSTANCE AND METHODS OF PRODUCING SUCH A DEVICE - Devices to detect a substance and methods of producing such a device are disclosed. An example device to detect a substance includes a housing defining an externally accessible chamber and a seal to enclose at least a portion of the chamber. The example device also includes a substrate includes nanoparticles positioned within the chamber. The nanoparticles to react to the substance when exposed thereto. The example device also includes a non-analytic solution within the chamber to protect the nanoparticles from premature exposure. | 07-17-2014 |
20140212985 | PREPARATION OF REACTION CHAMBERS WITH DRIED PROTEINS - The present invention relates to a method of applying a spot of an unlabelled biomolecule, e.g. antibody or protein antigen, to a surface of a reaction chamber of a diagnostic assay. This method comprising the steps of applying to the surface of the reaction chamber a solution comprising a sugar and comprising a non-labelled biomolecule, e.g. antibody or protein antigen, and allowing the solution to dry. In this method the biomolecule is in a concentration sufficient to saturate the binding places for a protein on the surface where the solution has been applied to. The present invention relates to a reaction chamber of a diagnostic device for performing a biomolecule, e.g. antibody or protein antigen, based detection assay. Herein,the reaction chamber comprises a detection region with one or more spots of an unlabelled biomoleculespots bound to the detection region. The one or more spots have a diameter of between 0.1 to 0.5 mm. The spot comprises a sugar and a protein and comprises between 0.01 and 0.5 ng biomolecule. | 07-31-2014 |
20140256058 | SAMPLE TUBE WITH IMPROVED LID - The present invention discloses a lid for a sample tube and a sample tube enabling ventilation or sealing depending on the closing position of the lid. Furthermore, a method for drying a sample and a use of the above lid or of the above sample tube for storing or drying a sample are subjects of the present invention. | 09-11-2014 |
20140273266 | REACTOR CELL ASSEMBLY FOR USE IN SPECTROSCOPY AND MICROSCOPY APPLICATIONS - The present disclosure provides a reactor cell assembly that utilizes a novel design and that is wholly or partially manufactured from Aluminum, such that reactions involving Hydrogen, for example, including solid-gas reactions and thermal decomposition reactions, are not affected by any degree of Hydrogen outgassing. This reactor cell assembly can be utilized in a wide range of optical and laser spectroscopy applications, as well as optical microscopy applications, including high-temperature and high-pressure applications. The result is that the elucidation of the role of Hydrogen in the reactions studied can be achieved. Various window assemblies can be utilized, such that high temperatures and high pressures can be accommodated and the signals obtained can be optimized. | 09-18-2014 |
20140315325 | ASSEMBLY COMPRISING A REACTION VESSEL AND A SAMPLE MATRIX, SAMPLE MATRIX COMPRISING AN UPPER ADSORBENT LAYER AND A LOWER LATERAL FLOW LAYER - An assembly and related methods are described for the preparation and processing of samples in molecular biology assays and nucleic acid amplification reactions. The assembly allows rapid and easy processing with reduced sample handling compared to known sample preparation apparatus and methods. The assembly comprises a reaction vessel, a sample matrix and a lid. The invention further provides an integrated punch to punch out discs of the sample matrix into the reaction vessel (without handling); thereby reducing the sample handling required to generate the final amplified nucleic acid product. | 10-23-2014 |
20140335627 | METHOD AND APPARATUS FOR STORING AND DISPENSING REAGENT BEADS - Embodiments of the invention provide an efficient and effective technique for storing and dispensing reagent beads. In some embodiments, an apparatus is provided for dispensing reagent beads contained in a bead storage device which includes a bead carrier having a plurality of wells; a plurality of reagent beads disposed in the wells; and a cover tape releasably attached to the bead carrier to cover the wells and retain the reagent beads in the wells. The apparatus comprises a channel in which to place the bead storage device with the bead carrier facing a support wall of the channel and the cover tape facing a stripping wall of the channel. The stripping wall includes a stripping gap disposed between a stripping edge and an opposite edge, and a dispense opening provided adjacent the opposite edge on a side of the stripping wall opposite from the stripping edge. The cover tape is insertable through the stripping gap to be pulled against the stripping edge to peel the cover tape from the bead carrier to move the wells of the bead carrier inside the channel toward the dispense opening and expose the wells individually to dispense the reagent beads. | 11-13-2014 |
20140342465 | LABORATORY AUTOMATED SYSTEM WITH COMMON SAMPLE BUFFER MODULE - A new laboratory automated system comprising a plurality of work cells coupled to a conveyor and a method for processing sample tubes are disclosed, both of which enable a system to maintain the maximum overall throughput regardless of the number and throughput of the individual work cells and regardless of the frequency at which sample tubes are loaded into the system. This is achieved by a sample buffer module coupled to the conveyor, the sample buffer module being in common to the plurality of work cells, and by a sample workflow manager configured to dispatch sample tubes from the sample buffer module to the work cells via the conveyor with a frequency for each work cell, which is equal to the sample processing throughput of each respective work cell. | 11-20-2014 |
20150011011 | METHOD FOR PERFORMING IMMUNOASSAYS UNDER WEIGHTLESSNESS - A method for controlled movement of magnetic carriers in a sample volume for performing immunoassays under weightless or reduced-weight conditions, wherein the magnetic carriers are moved inside the sample volume by means of permanent magnets movably arranged relative to at least one spatial axis of the sample volume. | 01-08-2015 |
20150087077 | SAMPLE COLLECTION DEVICE FOR OPTICAL ANALYSIS - A sample collection device is provided, which includes a laminate structure which includes at least a first layer and a second layer and a channel sandwiched between the two layers. The channel has an opening at a first end of the laminate structure. The first layer includes a depressible bulb pump disposed distal to the opening of the channel. Depressing and releasing the bulb pump draws a fluid or liquid sample into the channel. The sample collection device can further includes a pad attached to the laminate structure for providing structural support and easy handling. The layers of the sample collection device can be IR neutral so that the device can be used in association with a portable IR or near-IR spectroscopy unit for analyzing the collected sample. | 03-26-2015 |
20150125963 | TECHNIQUES FOR ENSURING IDENTIFICATION AND CHAIN OF CUSTODY INFORMATION OF DRIED SAMPLES - Techniques for use with dried sample portions include a device having sample areas, identification areas and detachable portions. Each sample area includes one of the dried sample portions of the sample. Each identification area includes information stored therein which identifies the sample from which the dried sample portions stored on the sample areas of the device are obtained. Each detachable portion includes one of the sample areas and includes one of the identification areas. Also described is a method for processing dried sample portions of a sample. A card is received that includes a plurality of detachable portions. Each detachable portion includes a sample area with a dried sample portion and an identification area including information that identifies the sample. A first detachable portion is detached to process a dried sample portion included in the first detachable portion. | 05-07-2015 |
20150308929 | Signature Collection Cartridge With Embossed Collection Substrate | 10-29-2015 |
20150314286 | LIQUID HOLDING APPARATUS FOR INSERTION OF A TEST DEVICE INTO A TEST LIQUID - A liquid holding apparatus has a liquid holding device and a backing attached to the liquid holding device. The liquid holding device has a front wall and a rear wall and includes a periphery wherein the front wall and the rear wall are sealed together. The upper section of the liquid holding device has an access section where the front wall can be detached from the rear wall to allow access for a test device. At least a portion of the front wall is substantially transparent. The backing is stiffer than both the front wall and the rear wall. | 11-05-2015 |
20150355077 | CARTRIDGE FOR INSPECTION APPARATUS AND METHOD OF RETAINING LIQUID - A cartridge for inspection apparatus includes a container, a flow path, and a reservoir. The container is configured to contain a liquid and includes a bottom surface having a functional layer that is reactive to a test sample contained in the liquid. The flow path includes an opening above the container and introduces the liquid that has flowed therein from the opening to the container. The reservoir is configured to retain the liquid, and includes an opening that is larger than the opening of the flow path and a bottom surface that is connected to the opening of the flow path. | 12-10-2015 |
20160003861 | CAP CLOSURE WITH CANNULA - An analyzer for use with in vitro diagnostics includes one or more containers. Each container includes a container body configured to hold one or more fluids, a closure device disposed on the container body and housing a movable cannula, and a sealing portion configured to seal off the one or more fluids in the container body from matter outside the container body when the sealing portion is closed. The system also includes one or more pick and place devices configured to move the one or more containers between different locations. The movable cannula is configured to move downward responsive to a force from the one or more pick and place devices and cause an opening in the sealing portion. | 01-07-2016 |
20160018299 | DOUBLE TRENCH WELL FOR ASSAY PROCEDURES - Apparatuses, systems and methods for using assay preparation plates comprising wells with two trenches are presented. More specifically, well plates are presented that comprising an array of wells configured to retain a plurality of beads suspended in a fluid during an assay procedure, each well in the array comprising a first trench and a second trench, wherein the working volume of each well is between about 25 uL and about 10 mL. | 01-21-2016 |
20160033375 | TESTING MODULE AND METHOD FOR TESTING TEST SAMPLE - A testing module is provided. The testing module includes a carrier, a block member, and a sampling assembly. A flow path connects a storage chamber to a mixing chamber to guide the flow of a fluid. The block member is formed in the flow path to block the fluid from flowing from the storage chamber to the mixing chamber before the connection of the sampling assembly. When the sampling assembly which contains a test sample is connected to the carrier, the fluid mixes with the test sample and flows to the mixing chamber. | 02-04-2016 |
20160076977 | METHODS FOR SAMPLING FROM NON-ATMOSPHERIC VESSELS IN A PARALLEL REACTOR SYSTEM - Methods for sampling reactor contents in parallel reactor systems are disclosed. The methods may be used to sample reactor contents in non-atmospheric (e.g., pressurized) reaction vessels. | 03-17-2016 |
20160103046 | Blood Sample Management Using Open Cell Foam - A specimen mixing and transfer device adapted to receive a sample is disclosed. The specimen mixing and transfer device includes a housing, a material including pores that is disposed within the housing, and a dry anticoagulant powder within the pores of the material. In one embodiment, the material is a sponge material. In other embodiments, the material is an open cell foam. In one embodiment, the material is treated with an anticoagulant to form a dry anticoagulant powder finely distributed throughout the pores of the material. A blood sample may be received within the specimen mixing and transfer device. The blood sample is exposed to and mixes with the anticoagulant powder while passing through the material. | 04-14-2016 |
20190143318 | Device and a Method for Collecting and Transferring Samples of Biological Material | 05-16-2019 |