Class / Patent application number | Description | Number of patent applications / Date published |
436069000 | CLOTTING OR CLOTTING FACTOR LEVEL TESTS | 39 |
20080241941 | REAGENT FOR MEASURING CLOTTING TIME AND METHOD FOR STABILIZING TISSUE FACTOR - The present invention provides a reagent for measuring clotting time comprising a nonionic surfactant, a nickel ion and a tissue factor. A method for stabilizing a tissue factor, and use of a nonionic surfactant and a nickel salt for stabilizing a tissue factor are also disclosed. | 10-02-2008 |
20090191641 | IMMUNODIAGNOSTIC TEST CARDS HAVING INDICATING INDICIA - An immunodiagnostic test card includes a plurality of transparent chambers wherein each chamber includes a quantity of testing material that combines with a patient sample, when mixed, to produce an agglutination reaction. A plurality of indicia are disposed to aid in the manufacture and determining the usability of the cards prior to test and also in objectively grading the agglutination reactions that are formed or lack of agglutination. | 07-30-2009 |
20090275141 | Affinity Adsorbents for Factor VIII and Von Willebrand's Factor - For the separation, removal, isolation, purification, characterisation, identification or quantification of Factor VIII, von Willebrand's Factor or a protein that is a analogue of either, an affinity adsorbent is used that is a compound of formula (II) wherein one X is N and the other is N, C—Cl or C—CN; A is a support matrix, optionally linked to the triazine ring by a spacer; Y is O, S or NR | 11-05-2009 |
20090280570 | METHOD FOR TESTING EFFICACY OF ANTITHROMBOTIC AGENT - The present invention provides a method for testing quickly and easily the manner in which an antithrombotic agent inhibits the acceleration of blood coagulation when a platelet agonist causes acceleration of blood coagulation. The invention is a test method wherein a system in which an anticoagulant is added to a portion of blood sampled from a patient being administered an antithrombotic agent (X system blood), and a system in which an anticoagulant and adenosine diphosphate or collagen are added to a portion of the abovementioned blood (Y system blood) are simultaneously measured by thromboelastograph; and the efficacy of the antithrombotic agent is assessed by comparing the R values of the X system blood and the Y system blood. If the R value of the Y system blood is not found to differ significantly from the R value of the X system blood, the drug is judged to be working. Adenosine diphosphate and collagen can be used as the anticoagulant. The present invention provides a heretofore unknown method for easily assessing the efficacy of an antithrombotic agent. | 11-12-2009 |
20100240136 | APPARATUS AND METHOD FOR ASSAYING COAGULATION IN FLUID SAMPLES - This invention is a disposable cartridge for use at the patient side to perform traditional coagulation assays on fresh whole blood or blood derivative samples. The cartridge, in use with an electronic analyzer allows a fluid sample to be metered and quantitatively mixed with reagents which activate the coagulation cascade. An artificial substrate for thrombin, the enzyme whose action results in clot formation is also provided. Clot formation is subsequently detected using a microfabricated sensor also housed within the cartridge which detects electrochemically the product of the thrombin reaction upon the synthetic substrate. | 09-23-2010 |
20110159597 | ACTIVATED PARTIAL THROMBOPLASTIN TIME MEASURING REAGENT, ACTIVATED PARTIAL THROMBOPLASTIN TIME MEASURING METHOD, AND DETERMINATION METHOD FOR DETERMINING PRESENCE OR ABSENCE OF BLOOD COAGULATION INHIBITOR - An activated partial thromboplastin time measuring reagent, comprising a heparin neutralizer is disclosed. An activated partial thromboplastin time measuring method, and a determination method for determining a presence or absence of a blood coagulation inhibitor are also disclosed. | 06-30-2011 |
20120142114 | Methods and Apparatus for Measuring Blood Coagulation - The present invention provides apparatus and methods for performing assays for determining the time required for a sample of blood to coagulate. The apparatus comprises reaction chambers coated with one or more clotting agent. A drop of blood or equivalent is placed at the sample application port, diluted, and contacted with the clotting agents in the reaction chambers. The diluted blood sample can be moved back and forth through the reaction chambers until blood clots. The blood clotting process forms fibrin stands that prevent the flow of the blood sample in the reaction chambers. The clotting time is the total time from the sample entering the reaction chambers to the time at which the waveform in the reaction chambers change, or the motion or flow of the sample ceases, and can be measured by turbidity. | 06-07-2012 |
20120156791 | METHODS AND SYSTEMS FOR USING ACTUATED SURFACE-ATTACHED POSTS FOR ASSESSING BIOFLUID RHEOLOGY - Methods, systems, and computer readable media for using actuated surface-attached posts for assessing biofluid rheology are disclosed. According to one aspect, a method for testing properties of a biofluid specimen includes placing the specimen onto a micropost array having a plurality of microposts extending outwards from a substrate, wherein each micropost includes a proximal end attached to the substrate and a distal end opposite the proximal end, and generating an actuation force in proximity to the micropost array to actuate the microposts, thereby compelling at least some of the microposts to exhibit motion. The method further includes measuring the motion of at least one of the microposts in response to the actuation force and determining a property of the specimen based on the measured motion of the at least one micropost. | 06-21-2012 |
20120220038 | REAGENT KIT FOR DETECTING LUPUS ANTICOAGULANT AND METHOD OF DETERMINING PRESENCE OR ABSENCE OF LUPUS ANTICOAGULANT - In order to provide a reagent kit for detecting LA which can clearly separate a lupus anticoagulant (LA)-positive specimen group from an LA-negative specimen group, it is configured that the reagent kit for detecting LA contains a first clotting time-measuring reagent and a second clotting time-measuring reagent and at least one of the first clotting time-measuring reagent and the second clotting time-measuring reagent contains alkali metal salt. The presence or absence of LA can be determined using the kit. | 08-30-2012 |
20120238026 | BLOOD COAGULATION SYSTEM ANALYZING METHOD AND BLOOD COAGULATION SYSTEM ANALYZING DEVICE - A blood coagulation system analyzing method includes acquiring information relating to the coagulability of blood based on a change generated in a complex permittivity spectrum measured in a coagulation process of the blood due to addition of a substance that activates or inactivates platelets to the blood. | 09-20-2012 |
20120252127 | Optical Blood Coagulation Monitor and Method - An optical blood coagulation monitor and method. The monitor has a blood sample holder, a laser with its output light directed through the blood sample, a two-dimensional detector that is able to detect light at the laser light wavelength and that has a detector output, optics for imaging onto the detector laser light that is forward scattered by the blood, and a data analysis system, responsive to the detector output, that is adapted to analyze the detected light to provide information on time-resolved coagulation and clotting properties of the blood. | 10-04-2012 |
20120301967 | OPTICAL THROMBOELASTOGRAPHY SYSTEM AND METHOD FOR EVALUATION OF BLOOD COAGULATION METRICS - Device, method, and computer program product for determining a material parameter of a blood coagulation cascade based on parameters of light diffused at a biofluid sample. In one example, the biofluid sample includes a blood sample. Laser light scattered by the sample is collected by the optical system in reflection and/or transmission mode. An image of the sample in so collected light is formed, and data representing fluctuations of laser speckle intensity with is processed to derive numerical descriptors associated with blood coagulation and fibrinolysis. In a specific case, such numerical descriptors are derived based on temporal dynamic of a viscoelastic characteristic of the blood sample. | 11-29-2012 |
20130164855 | METHOD OF MONITORING THROMBUS FORMATION - A method of monitoring thrombus formation is described, which comprises flowing anticoagulated blood into a thrombus formation chamber, in at least a part of which a thrombus formation inducer inducing thrombus formation is provided, while releasing the anticoagulant treatment or promoting blood coagulation to thereby monitor thrombus formation in the thrombus formation chamber. | 06-27-2013 |
20130171736 | BLOOD COAGULATION DETECTION DEVICE AND METHOD - A blood coagulation detection device includes a micro channel unit, an optical signal unit, an opto-electronic conversion circuit, an amplifier circuit, and a filter circuit. The micro channel unit has a sample detection area. The optical signal unit transmits a reference light to the micro channel unit so as to form a message light. The opto-electronic conversion circuit receives the message light and converts the message light into an electrical signal. The amplifier circuit is electrically connected to the opto-electronic conversion circuit for amplifying the electrical signal. The filter circuit is electrically connected to the amplifier circuit for filtering the amplified electrical signal. | 07-04-2013 |
20130189789 | High Range Activated Clotting Time Assay Formulation - High range activated clotting time (HR-ACT) tests detect blood clotting time in blood samples which have high levels of heparin. Reagents such as calcium chloride and kaolin within the test apparatus trigger clotting. Physical separation of the reagents from each other prevents interaction between them before the test sample introduction. In one embodiment, to improve dry kaolin re-suspension, kaolin may be suspended in water rather than buffered saline before being dispensed into the test chamber. The combination of removing the buffered saline and the calcium chloride from the kaolin suspension enables clot detection in blood samples containing 5-6 u/ml of heparin. | 07-25-2013 |
20130323846 | CARTRIDGE DEVICE FOR A MEASURING SYSTEM FOR MEASURING VISCOELASTIC CHARACTERISTICS OF A SAMPLE LIQUID, A CORRESPONDING MEASURING SYSTEM, AND A CORRESPONDING METHOD - The present invention is directed to a cartridge device for a measuring system for measuring viscoelastic characteristics of a sample liquid, in particular a blood sample, comprising a cartridge body having at least one measurement cavity formed therein and having at least one probe element arranged in said at least one measurement cavity for performing a test on said sample liquid; and a cover being attachable on said cartridge body; wherein said cover covers at least partially said at least one measurement cavity and forms a retaining element for retaining said probe element in a predetermined position within said at least one measurement cavity. The invention is directed to a measurement system and a method for measuring viscoelastic characteristics of a sample liquid. | 12-05-2013 |
20130323847 | CARTRIDGE DEVICE FOR A MEASURING SYSTEM FOR MEASURING VISCOELASTIC CHARACTERISTICS OF A SAMPLE LIQUID, A CORRESPONDING MEASURING SYSTEM, AND A CORRESPONDING METHOD - The present invention is directed to a cartridge device for a measuring system for measuring viscoelastic characteristics of a sample liquid, in particular a blood sample, comprising a cartridge body having at least one measurement cavity formed therein and having at least one probe element arranged in said at least one measurement cavity for performing a test on said sample liquid; and a cover being attachable on said cartridge body; wherein said cover covers at least partially said at least one measurement cavity and forms a retaining element for retaining said probe element in a predetermined position within said at least one measurement cavity. The invention is directed to a measurement system and a method for measuring viscoelastic characteristics of a sample liquid. | 12-05-2013 |
20130323848 | CARTRIDGE DEVICE FOR A MEASURING SYSTEM FOR MEASURING VISCOELASTIC CHARACTERISTICS OF A SAMPLE LIQUID, A CORRESPONDING MEASURING SYSTEM, AND A CORRESPONDING METHOD - The present invention is directed to a cartridge device for a measuring system for measuring viscoelastic characteristics of a sample liquid, in particular a blood sample, comprising a cartridge body having at least one measurement cavity formed therein and having at least one probe element arranged in said at least one measurement cavity for performing a test on said sample liquid; and a cover being attachable on said cartridge body; wherein said cover covers at least partially said at least one measurement cavity and forms a retaining element for retaining said probe element in a predetermined position within said at least one measurement cavity. The invention is directed to a measurement system and a method for measuring viscoelastic characteristics of a sample liquid. | 12-05-2013 |
20130344606 | Heparin Concentration and Heparin Response Imbalance Determination Method Within a Fluid Containing Heparin - Provided herein are various methods for determining heparin concentration or heparin response imbalance in native whole blood, citrated whole blood, or plasma by measuring two parameters that characterize each phase of a two-phase coagulation response, such as a time period until clot formation initiation and a post-initiation clot formation. | 12-26-2013 |
20140004613 | MULTIPLE COAGULATION TEST CARTRIDGE AND METHOD OF USING SAME | 01-02-2014 |
20140038299 | MICROFLUIDIC DEVICE AND METHOD FOR FLUID CLOTTING TIME DETERMINATION - A method for determining clotting time is described, of a fluid medium such as blood.
| 02-06-2014 |
20140065715 | APPARATUS AND METHOD OF PLATELET MULTI-FUNCTION ANALYSIS, AND MICRO STIRRING CHIP - An apparatus and method for platelet multi-function analysis using measurement of electrical characteristics, and a stirring microchip are provided. The apparatus for platelet multi-function analysis includes a stirring microchip that has a sample storage chamber formed therein to hold a blood sample, and in which an inner part of the sample storage chamber is coated with reagents composed of collagen and epinephrine, or collagen and ADP. The apparatus for platelet multi-function analysis further includes a microstirrer installed inside the stirring microchip to stir the blood sample and the reagents in the stirring microchip and a stirring induction unit configured to facilitate stirring of the microstirrer. Therefore, the platelet aggregation and multi-function analysis can be performed using a trace of blood, and the platelet aggregation and multi-function analysis can also be performed using the whole blood taken from the veins through a vacuum tube containing an anticoagulant. | 03-06-2014 |
20140186963 | Microfluid Testing System with a Multiple-Channel Disc and Utility thereof - The present invention discloses a system for testing microfluid which is made with a disposable disc. The high sensitivity, high sensing accuracy, and quick response microfluidic disc is demonstrated in the present invention. It is note that easy to test microfluid without traditional detecting method, and then reduce energy and simplify procedure. Furthermore, to additive the microfluidic disc is useful to enhance blood typing, and hence raising the sensitivity by the video recognition of blood agglutination. | 07-03-2014 |
20140199772 | PROCEDURE AND AUTOMATIC APPARATUS FOR IN VITRO BLOOD COAGULATION DIAGNOSTIC TESTS - Apparatus and processes for automated diagnostic testing may include cuvette dispensing, test sample dispensing, reagent dispensing, incubation, photo-optical measuring, and a control in operative communication with the cuvette dispensing unit, the test sample dispenser, the reagent dispenser, the incubation unit, and the measuring unit. A cuvette removal location, a reagent removal location, a measuring location, and a collection receptacle may be situated along a first common circular arc having first geometric center. A cuvette-moving arm and a reagent-dispensing arm have a common axis of rotation passing through this geometric center. A sampling position, a sample dispensing position, an additional rinsing position, and an additional washing position, may all be provided on a second circular arc having second geometric center that has a second axis of rotation for a rotatable sampling arm of the test sample dispenser. The apparatus and processes may be employed for photo-optical analysis of blood plasma samples. | 07-17-2014 |
20140242707 | Compositions and Methods for Diagnosing Hypercoagulability and Hypocoagulability - The present invention provides a method for diagnosing hypercoagulability associated with carbon monoxide exposure in a subject. The method comprises obtaining a plasma sample from the subject, dividing the sample into at least two portions, and determining the clot strength of the first portion. The method further comprises exposing the second portion to an organic reductant, determining the clot strength of the second portion after exposure to the organic reductant, and comparing the clot strength of the first portion with the clot strength of the second portion. A diagnosis of hypercogulability associated with carbon monoxide exposure is made when the clot strength of the second portion is decreased compared with the cloth strength of the first portion. | 08-28-2014 |
20140256052 | APPARATUS AND METHOD FOR ANALYZING BLOOD CLOTTING - The invention includes systems, apparatuses and methods to evaluate the strength of clotting in addition to or separate from activated clotting time. The strength of clotting may be correlated with the amount of energy employed to move an object within blood. The strength of clotting may be correlated with the amount of time for fibrinolysis to occur. The strength of clotting may be determined by a system in which a ferromagnetic material is moved within blood. | 09-11-2014 |
20140273249 | High Range Activated Clotting Time Assay Formulation - High range activated clotting time (HR-ACT) tests detect blood clotting time in blood samples which have high levels of heparin. Reagents such as calcium chloride and kaolin within the test apparatus trigger clotting. The cartridge is treated with a strong surface treatment process, such as an atmospheric plasma treatment, to increase the hydrophilic property of the test chamber, there may be a significant reduction in the kaolin concentration required to activate the blood sample and initiate the coagulation process. The kaolin concentration may be further reduced if the buffer component used in the buffer saline contains phosphate. The reduction of the kaolin concentration allows more calcium to be released from the kaolin to participate in the clotting process. The combined effect of adding a surface treatment to the cartridge to increase the hydrophilic property of reaction chamber and adding phosphate into buffered saline allows for clot detection of blood samples containing 5˜6 U/mL heparin. | 09-18-2014 |
20150140671 | METHOD AND SYSTEM FOR ASSEMBLING A MICROFLUIDIC SENSOR - A microfluidic sensor ( | 05-21-2015 |
20150293130 | Method for testing microfluids by a multichannel system with a multichannel disc - The present invention discloses a system for testing microfluid which is made with a disposable disc. The high sensitivity, high sensing accuracy, and quick response microfluidic disc is demonstrated in the present invention. It is note that easy to test microfluid without traditional detecting method, and then reduce energy and simplify procedure. Furthermore, to additive the microfluidic disc is useful to enhance blood typing, and hence raising the sensitivity by the video recognition of blood agglutination. | 10-15-2015 |
20150316533 | METHODS AND SYSTEMS FOR POINT-OF-CARE COAGULATION ASSAYS BY OPTICAL DETECTION - This invention relates to an optical system and method for performing turbidity assay, e.g. coagulation of blood or plasma, comprising a standard optical reference, a sample handling structure, a light source and an optical detection unit. The standard optical reference, such as a fluorophore-doped glass, provides constant optical signal under controlled optical conditions. The sample handling structure, such as a microfluidic system with reaction chamber, can be placed beneath or above the standard optical reference. During operation, the coagulating plasma/blood changes its optical absorbance and reflection properties, which results in changes in optical signal that reaches the optical reading unit. The variation of the optical signal, such as fluorescence signal indicates the kinetics of the turbidity varying process, such as plasma/blood coagulation process. This invention is used for performing turbidity assay with optical system, including photometry system, fluorescence system, Raman Spectroscopy system and so on. | 11-05-2015 |
20150374269 | Methods and Apparatus for Rapid Monitoring of Hemostatic State - Improved monitoring of one or more blood coagulation factors is provided. Factor-specific molecular probes having a dye-quencher arrangement are employed. In preferred embodiments, a compact integrated optical source and detector device is used for fluorescence measurements. Continuous and real-time monitoring of the activity of one or multiple blood factors is provided. Such real-time information can be used to automatically control delivery of drugs such as coagulants and/or blood thinners. | 12-31-2015 |
20160018387 | PERFUSION DEVICE, CORRESPONDING APPARATUS USING SAID PERFUSION DEVICE AND METHOD TO ANALYZE THE THROMBOTIC-ISCHEMIC AND HEMORRHAGIC PATHOLOGY - Perfusion device for the dynamic analysis of the thrombotic-ischemic and hemorrhagic pathology, comprising at least one micro-channel ( | 01-21-2016 |
20160047827 | Apparatus for Analyzing the Process of Formation of Aggregates in a Biological Fluid and Corresponding Method of Analysis - Apparatus for analyzing the process of formation of aggregates in a biological fluid, such as blood or hematic fluids, comprising a perfusion chamber provided with at least one micro-channel through which the biological fluid flows, and in which at least one reactive substrate is present, such as a cyto-adhesive substrate, to stimulate the aggregation process in the biological fluid, and impedenziometric detection means associated with the micro-channel, in correspondence to at least one investigation area and disposed, during use, in contact with the flow of biological fluid in transit, in order to detect impedance data of the biological fluid. The impedenziometric detection means comprise at least two first electrodes with an oblong development disposed in the micro-channel, and a plurality of second electrodes with an oblong development disposed in the space comprised between the first electrodes and according to a pattern defining substantially the perimeter of a geometric figure. | 02-18-2016 |
20160082433 | MICROFLUIDIC EVALUATION SYSTEM FOR EVALUATING THE EFFICACY OF AN ANTIPERSPIRANT PRODUCT AND ASSOCIATED METHOD - This invention relates to a microfluidic evaluation system ( | 03-24-2016 |
20160091483 | Blood Testing System and Method - Some embodiments of a blood coagulation testing system include an analyzer console device and a single-use cartridge component configured to releasably install into the console device. In some embodiments, the blood coagulation testing system can operate as an automated thromboelastometry system that is particularly useful, for example, at a point-of-care site. | 03-31-2016 |
20160091512 | ELLAGIC ACID FORMULATIONS FOR USE IN COAGULATION ASSAYS - The present invention relates to ellagic acid formulations for performing coagulation assays that are highly stable for long term storage and reduce assay time. Particularly, aspects of the present invention are directed to a composition and method of preparing ellagic acid in a highly soluble format for use in a coagulation assay. For example, the ellagic acid may be solubilized in one or more of sodium hydroxide, methanol, a polyether compound, particularly polyethylene glycol, polyethylene oxide, or polyoxyethylene, and a cyclodextrin guest-host complex. | 03-31-2016 |
20160091515 | Blood Testing System and Method - Some embodiments of a blood coagulation testing system include an analyzer console device and a single-use cartridge component configured to releasably install into the console device. In some embodiments, the blood coagulation testing system can operate as an automated thromboelastometry system that is particularly useful, for example, at a point-of-care site. | 03-31-2016 |
20160116491 | BLOOD COAGULATION TEST METHOD | 04-28-2016 |
20160195557 | Cartridge Device For A Measuring System For Measuring Viscoelastic Characteristics Of A Sample Liquid, A Corresponding Measuring System, And A Corresponding Method | 07-07-2016 |