Class / Patent application number | Description | Number of patent applications / Date published |
436063000 | BIOLOGICAL CELLULAR MATERIAL TESTED | 62 |
20080213905 | Methods of assessing the need for and the effectiveness of therapy with antioxidants - The invention relates to diagnostic methods for assessing the need of a subject for treatment with an anti-oxidant, or alternatively, for determining the utilization efficiency and ultimate effectiveness of anti-oxidant therapy in subjects having been treated with antioxidants. More specifically, the methods of the present invention are particularly useful in prophylactic assessment of individuals at risk for developing diseases or conditions in which oxidative stress plays a role, such that an appropriate therapeutic regimen can be prescribed for that individual, thus leading to alternative therapies and/or life style changes. The invention further relates to methods for assessing the need for, the utilization efficiency and the effectiveness of therapy in subjects having received therapy with specific antioxidant and immune enhancing formulations. Kits are also provided for measuring the levels of markers of oxidative stress and immune cell numbers. | 09-04-2008 |
20080213906 | COMPOSITIONS AND METHODS FOR COMBINING PROTEIN PRECIPITATION AND SOLID PHASE EXTRACTION - A composition, method and device for the preparation of biological samples for subsequent LC-MS analysis using a combined and concurrent protein precipitation and solid phase extraction (SPE) process is described. Through an integrated combination of protein precipitation, filtration, and SPE using a novel zirconia-coated chromatographic media, interfering compounds, such as proteins and phosphate-containing compounds, are eliminated from the biological samples, affording a higher degree of analyte response during LC-MS analysis. | 09-04-2008 |
20080220530 | Biomarkers - The invention relates to methods for diagnosing or monitoring psychotic disorders such as schizophrenic or bipolar disorders, comprising measuring the level of one or more biomarker(s) present in a cerebrospinal fluid sample taken from a test subject, said biomarker(s) being selected from the group consisting of: glucose, lactate, acetate species and pH. The invention also relates to methods of diagnosing or monitoring a psychotic disorder in a subject comprising providing a test sample of CSF from the subject, performing spectral analysis on said CSF test sample to provide one or more spectra, and, comparing the one or more spectra with one or more control spectra. The invention also relates to sensors, biosensors, multi-analyte panels, arrays, assays and kits for performing methods of the invention. | 09-11-2008 |
20080233655 | Screening For Lysosomal Storage Disease Status - A method of ascertaining the LSD (Lysosomal storage disorder) status of an individual comprising taking a tissue or body fluid sample from the individual and estimating a level in the sample of each of three or more compound indicators. The indicators reflect the level of respectively each of three or more lipid containing storage associated compounds. The levels are used to calculate an LSD index number which is then compared with a standard to provide an assessment of the LSD status of the individual. The indicator compounds are conveniently phospholipids, glycolipids or lipopolysaccharide species measured by mass spectrometry. The method may be used to ascertain the nature of the disorder from which the individual stuffers, and its severity. It may also be used to monitor the progress of treatment and to ascertain the prospects of an individual contracting an LSD by providing a subclinical indicators for the condition. | 09-25-2008 |
20080274554 | OXIMETER FOR SPECTRO-PHOTOMETRIC IN-VITRO DETERMINATION OF HEMOGLOBIN DERIVATIVES - An oximeter for spectro-photometric in-vitro determination of hemoglobin derivatives in a sample, typically a hemolyzed blood sample, is provided comprising a single measurement light source emitting measurement radiation, a sample chamber, for instance a measurement cuvette containing the sample, a detector device, which records a spectrum of the measurement radiation after its interaction with the sample, and an evaluation unit following the detector device, which determines the hemoglobin derivatives and at least one further analyte from the spectrum recorded by the detector device. The measurement light source is a polychromatic LED, which for determination of hemoglobin derivatives emits measurement radiation in at least one spectral region B, in which the hemoglobin derivatives exhibit significant absorbance, and which for determination of the at least one further analyte emits measurement radiation in at least one other spectral region A, in which the at least one further analyte exhibits significant absorbance. | 11-06-2008 |
20080280364 | Control of Apoptosis By Controlling the Propensity of Ceramide Channel Formation - The present invention relates to a novel target to control the apoptotic process, and to the use of this target to identify compounds capable of affecting the apoptotic process, The invention also relates to the use of such identified compounds in the treatment of cancer, stroke, neurodegenerative diseases, viral diseases and other diseases and conditions involving apoptosis. | 11-13-2008 |
20080286874 | REDUCING OR AVOIDING MUSCLE CRAMPS - Muscle cramps can be reduced or avoided by monitoring the concentration of salt in perspiration to indicate the degree of salt depletion. Based on the degree of salt depletion, a sufficient amount of rehydration beverage is consumed to normalize the salt level. | 11-20-2008 |
20080293146 | Method And Apparatus For Compensating For Variations In Particle Trajectories In Electrostatic Sorter For Flowcell Cytometer - A flow cytometer subsystems monitors a particle sensing zone within a fluid transport chamber for the presence of a particle (e.g., blood cell) traveling therethrough, and produces an output pulse, whose width is representative of the trajectory and thereby the length of time that the particle is within the particle sensing zone as it travels through the fluid transport chamber. This output pulse is then processed in accordance with geometry parameters of successive time delay zones of the particle fluid transport chamber through which the particle passes, in order to derive a composite time delay between the sensing of the particle to the time at which a fluid droplet containing the particle will break off from the carrier fluid. The composite time delay is employed to accurately establish the time at which the particle is controllably charged as the particle breaks off from the carrier fluid. | 11-27-2008 |
20090029476 | REACTION VESSEL, ANALYZER, AND METHOD OF ANALYSIS - A reaction vessel includes a storage space extending from a first end to a second ends the reaction vessel being configured to retain at least one of a reagent and a specimen in the storage space when the at least one of the reagent and the specimen is dispensed from the first end, and to discharge the at least one of the reagent and the specimen outside the storage space from the second end when a discharge operation is performed from outside. | 01-29-2009 |
20090081795 | Identification of Humans Through Characteristic Compounds Detected in Human Scent - The present invention is directed to methods of identifying and/or comparing humans. More particularly, the present invention is directed to methods of collecting human scent compounds from a subject, extracting the compounds, analyzing the compounds, and correlating the compounds to a unique compound profile for the subject. These unique compound profiles can be used to distinguish one subject from another, or to identify a specific subject based upon a sample. | 03-26-2009 |
20090104705 | Ascorbic acid conjugates - Oxidative stress, resulting from the generation of reactive oxygen species, contributes to the development of a multitude of age-related diseases. Current methods of assessing oxidative stress levels range from the detection of lipid peroxidation products, such as F | 04-23-2009 |
20090130766 | FLUID SAMPLE TRANSPORT DEVICE WITH REDUCED DEAD VOLUME FOR PROCESSING, CONTROLLING AND/OR DETECTING A FLUID SAMPLE - The present invention relates to a fluid sample transport device ( | 05-21-2009 |
20090137050 | Artificial protein, method for absolute quantification of proteins and uses thereof - The invention provides an artificial protein for quantitative analysis of the proteome of a sample, cell or organism, comprising at least two consecutive peptides linked by a cleavage sequence for separating the peptides; a singular marker on one or more peptide for determination of the absolute amount of this fragment; and N-terminal and C-terminal extensions for protection of the peptides; wherein each peptide represents one single protein of the sample, cell or organism and each peptide is in a defined stoichiometry. The invention further provides a collection of peptides, a vector and a kit comprising the artificial protein and a method for quantitative analysis of the proteome. | 05-28-2009 |
20090142847 | METAL ENHANCED FLUORESCENCE-BASED SENSING METHODS - The present invention relates to metallic-surface detection systems for determining target substances including free bilirubin in neonatal serum in the presence of a predominantly high background of bilirubin bound Human Serum Albumin (HSA) or sensing and isolating target nucleotide sequences wherein a fluorescence signal is enhanced by close proximity of the target substances near metallic surfaces. | 06-04-2009 |
20090162938 | Novel Carbohydrate Profile Compositions From Human Cells and Methods for Analysis and Modification Thereof - The invention describes methods for production of novel composition of glycans, glycomes, from human multipotent stem cells. The invention is further directed to methods for modifying the glycomes and analysis of the glycomes and the modified glycomes. Furthermore the invention is directed to stem cells carrying the modified glycomes on their surfaces. | 06-25-2009 |
20090191639 | Non-Invasive Rapid Diagnostic Test For M.Tuberculosis Infection - This invention relates to a test for detecting a | 07-30-2009 |
20090191640 | Methods of Screening for Atherosclerosis - Methods for screening for altered focal proliferation states in non-pregnant patients, which include detecting levels of pregnancy-associated plasma protein-A (PAPP-A), are described. Methods for identifying agents that alter the protease activity of PAPP-A, and pharmaceutical compositions and medical devices that include such agents also are described. | 07-30-2009 |
20090197341 | WATER SOLUBLE FILM BASED MATRIX TO COLLECT SAMPLES EXTRACTED FROM LIVING SPECIES - The invention relates to a water soluble film based matrix for collecting blood samples, urine samples, serum samples or any other type of samples extracted from living species; so as to avoid cross infection or spillage of samples during transportation of said samples. These samples can then used for further detection of virus, bacteria, finding new molecules, diagnosing genes or extraction of DNA. Also, said matrix will dissolve during analysis of the sample and thus there will be no disposal problems. | 08-06-2009 |
20090197342 | Marker for Inflammatory Conditions - Use of pregnancy-associated plasma protein-A as a marker for inflammatory conditions, and in particular, for acute coronary syndromes is described. | 08-06-2009 |
20090227036 | Method of diagnosis of pregnancy-related complications - A method for diagnosing pregnancy-related complications in a pregnant woman is provided. The method includes (a) providing a membrane phospholipid suspension; (b) exposing a first portion of the suspension to standard PP13; (c) exposing a second portion of the suspension to PP13 obtained from the woman; (d) measuring the production of prostaglandins in (b) and (c); and (e) comparing the amounts of prostaglandins produced in (b) and (c), a change in the amount of prostaglandins of (c) as compared to the amount of prostaglandins in (b) indicating the existence of a pregnancy-related complication in the woman. | 09-10-2009 |
20090253210 | DIFFERENTIAL HEMOLYSIS OF A WHOLE BLOOD SAMPLE - The invention relates to a method for differentially hemolyzing whole blood. It discloses method for detecting an analyte in a liquid sample known or suspected to comprise red blood cells and suspected or known to comprise eukaryotic cells, the method comprising the steps of processing said liquid sample with a membrane solubilizing agent under conditions appropriate to lyse cell membranes of red blood cells and at the same time not to cause precipitation of sample constituents, subjecting the processed sample to a chromatographic separation, and detecting the analyte. The differential hemolysis of red blood cells is of advantage in a method of detecting an analyte in a liquid sample that may comprise both erythrocytes as well as nucleated cells. The differential solubilization of red blood cells can be easily combined with an online detection methodology, like LC-MS, and is advantageous in the detection of many analytes, e.g. in the detection of folate or of immunosuppressive drugs, like tacrolimus or sirolimus. | 10-08-2009 |
20090298182 | HANDHELD ANALYZER FOR TESTING A SAMPLE - The invention relates to a handheld analyzer for testing a sample, in particular of a biological fluid, for a medically significant component. It comprises a test unit, which detects the correct positioning of an analytical consumable means in a conveyance pathway. According to this invention, the test unit has both an electric switch component which mechanically senses the positioning of the analytical consumable means and an optical sensor unit which optically senses the positioning of the analytical consumable means on the conveyance pathway. The handheld analyzer is controlled as a function of a comparison of the signals of the electric switch component and the optical sensor unit. It is possible in this way to reduce malfunctions or operating errors associated therewith. | 12-03-2009 |
20100093099 | DETECTION OF BLOOD PLASMA DANSHENSU AND SALVIANOLID ACID B DISSIPATING BLOOD STASIS BOTANICAL - A detection method of blood plasma danshensu and salvianolic acid B of dissipating blood stasis botanical is disclosed. The method includes: (1) pretreating mammalian plasma sample: applying the plasma with medicine to small column of Waters Oasis HLB activated by methanol and water; after leaching and eluting, drying and enriching the eluent; after redissolving with mobile phase, measuring by UPLC/MS; (2) UPLC/MS measuring: UPLC condition: chromatographic column: Acquity UPLC BEH C | 04-15-2010 |
20100216247 | Identification of Biomarkers for Screening and Monitoring of Prostate Cancer and Prostate Related Diseases - A system and method for determining presence of prostate cancer or prostate related diseases is provided. The method includes first obtaining a test sample from a test subject. Next, at least one ultrastructural biomarker indicative of prostate cancer within the sample may be identified. Thereafter, qualitative or quantitative data from the ultrastructural biomarker in the test sample can be obtained. The qualitative or quantitative data of the biomarker in the sample from the test subject can then be compared to that in a sample from a control subject for variations. The presence of qualitative and quantitative variations can act as a determinant for prostate cancer or prostate related diseases. | 08-26-2010 |
20100216248 | DISPOSABLE CHAMBER FOR ANALYZING BIOLOGIC FLUIDS - An apparatus for analyzing biologic fluid is provided that includes a first planar member, a second planar member, and at least three separators. At least one of planar members is transparent. The separators are disposed between the members, and separate the members to form a chamber having a height. At least one of the members or separators is sufficiently flexible to permit the chamber height to approximate the mean size of the separators. During use, the biologic fluid to be analyzed is disposed within the chamber. | 08-26-2010 |
20100279418 | GLUCOSE METER ADAPTABLE FOR USE WITH HANDHELD DEVICES, AND ASSOCIATED COMMUNICATION NETWORK - Module adaptable to communicate with a suitable handheld devices or PDAs. Suitable devices include, but are not limited to, the Apple iPhone® or iPod®, Research in Motion Blackberry® smart phones, Motorola Droid smart phones, and Palm Pre smart phones. The module can be used without adding to the cost of the handheld device. This allows direct reimbursement for the replaceable meter module portion if payers choose to limit coverage for the full system, as well as the possibility of reimbursement for the entire system including the handheld device. Other solutions build the cost into the phone, which must be replaced to upgrade or replace the glucose function. Moreover, information from the glucose meter reading can be communicated from the PDA to a remote station for reporting the results. With an iPod-like approach, this could be accomplished without the need for a cellular signal or carrier, as long as a WiFi internet connection is available anywhere in the world. | 11-04-2010 |
20100304492 | Method for methylmalonic acid detemination based on alkylative extraction associated to liquid chromatography coupled to mass spectrometry - The present invention relates to the determination of the presence of methylmalonic acid in biologic samples including the steps of methylmalonic extraction from the sample; derivatization of methylmalonic acid and use of mass spectrometry with negative mode atmospheric pressure chemical ionization to determine the presence of methymalonic acid through the formation of an ion of mass to charge ratio (m/z) 477. An additional objective of the present invention concerns diagnosis kits for determination of presence and quantification of methylmalonic acid based on the method mentioned before. | 12-02-2010 |
20100317118 | CAPTURING OF CELL FLUID AND ANALYSIS OF ITS COMPONENTS UNDER OBSERVATION OF CELLS AND INSTRUMENTS FOR THE CELL FLUID CAPTURING AND THE ANALYSIS - The invention provide the method to enable the molecular detections of cellular fluid of at least a single cell easily and rapidly and clarify the dynamics of life phenomena and molecular mechanisms very rapidly by conducting simultaneous observations of cellular morphological dynamism. At the same time, it provides the method of exploring active molecules. Even in case that the target is a single cell, the cellular fluid is directly sucked by the capillary tip and the fluid is subjected to the analysis directly. By performing this method under the observation of the cell with image-magnifying scopes, such as a microscope, the cellular fluid is sucked and captured by the nanospray ionization capillary tip even if the target is a single cell and the trapped sample is subjected to the mass spectrometer by nano-spraying the sample solution directly after addition of the ionization supporting solvent into the tip, and then the molecular components in the cellular fluid is detected. The detected molecular peaks specific to a certain state are identified by performing differential analysis or t-test between the data groups of cells in different states. | 12-16-2010 |
20110020941 | GLYCOSYLATION MARKERS FOR PANCREATITIS, SEPSIS AND PANCREATIC CANCER - The present invention provides novel biomarkers for use in the diagnosis and prognosis of cancer and chronic inflammation and further of diseases which are mediated by chronic inflammation. The biomarkers are glycoproteins, the levels of which have been correlated by the inventors to correspond to particular disease conditions. The invention further extends to methods for monitoring the response to therapy of a treatment of a cancerous or chronic inflammatory condition. | 01-27-2011 |
20110129931 | MICROFLUIDIC SYSTEM FOR DETECTING A BIOLOGICAL ENTITY IN A SAMPLE - According to various embodiments, a microfluidic system for detecting a biological entity in a sample volume is provided. The microfluidic system may include: a chamber configured to receive the sample volume, wherein the chamber includes a detection region for detecting the biological entity; a first port in fluid communication with the chamber; and a second port including a filter in fluid communication with the chamber; and wherein a fluid provided to the first port or the second port flows between the first port and the second port through the chamber. | 06-02-2011 |
20110183424 | SCREENING FOR NEUROTOXIC AMINO ACID ASSOCIATED WITH NEUROLOGICAL DISORDERS - Methods for screening for neurological disorders are disclosed. Specifically, methods are disclosed for screening for neurological disorders in a subject by analyzing a tissue sample obtained from the subject for the presence of elevated levels of neurotoxic amino acids or neurotoxic derivatives thereof associated with neurological disorders. In particular, methods are disclosed for diagnosing a neurological disorder in a subject, or predicting the likelihood of developing a neurological disorder in a subject, by determining the levels of β-N-methylamino-L-alanine (BMAA) in a tissue sample obtained from the subject. Methods for screening for environmental factors associated with neurological disorders are disclosed. Methods for inhibiting, treating or preventing neurological disorders are disclosed. | 07-28-2011 |
20120107940 | Methods for Analyzing Polar Metabolites of the Energy Metabolism - The present invention is concerned with the analysis of polar metabolites and provides methods for analyzing polar metabolites comprising extracting a biological sample with a ex-traction buffer comprising a phase separator and a volatile neutral ammonium salt under conditions which allow for immediate disruption of cells comprised by the biological sample, separating the polar metabolites comprised by the extract by chromatography, and analyzing the separated polar metabolites. Moreover, a method for quenching a biological sample comprising cellular material is contemplated. | 05-03-2012 |
20120149118 | APPARATUS AND METHOD USING ANTI-ADSORPTION AGENT TO FACILITATE SAMPLE MIXING AND ANALYSIS - An apparatus and method for analyzing a biological fluid sample is provided. The method includes the steps of: a) providing an analysis cartridge having a channel and an analysis chamber, wherein the channel is in fluid communication with the analysis chamber and includes at least one hydrophobic interior wall surface; b) admixing one or more anti-adsorption agents with fluid sample disposed within the channel, wherein the anti-adsorption agents are operable to inhibit adsorption of fluid sample onto the interior wall surface of the channel; c) moving the fluid sample into the analysis chamber; and d) analyzing the sample within the analysis chamber. | 06-14-2012 |
20120270326 | THROMBOCYTE FUNCTION DETERMINATION METHOD USING A RESONATOR - The invention relates to a method for determining haemostasis parameters by measuring vibration parameters of a resonator having a measuring surface which contacts a platelet containing sample fluid. The invention is characterized by the analysis of the characteristic of a vibration parameter over time, based on which the platelet function will then be assessed and a distinction will be made between the presence of an adhesion disorder or that of an aggregation disorder. | 10-25-2012 |
20120276641 | MICROFLUIDIC DEVICE PROVIDING DEGASSING DRIVEN FLUID FLOW - A device for blood-plasma separation and plasma-based blood analysis is described. The device uses blood samples smaller than 5 μL, (directly from the finger) and flow is achieved with a degassing-driven flow technique that causes blood to flow spontaneously into air-filled dead-end channels without external pumping mechanisms. | 11-01-2012 |
20120288945 | System and method for determining contaminants in wastewater including shipboard bilge water - A wastewater diagnostic system provides a housing that holds equipment to perform contaminant diagnostics in bilge water including shipboard bilge water. The wastewater diagnostic system utilizes a plurality of receptacles to house glass containers and reagents. The wastewater diagnostic system of the preferred embodiment includes shock-absorbing materials in the compartments to prevent movement and securely house glass containers and reagents. The wastewater diagnostic system further utilizes a flat work surface portion providing a test bed to conduct tests in non-laboratory environments. The system also provides methods to conduct tests to determine contaminants while utilizing the system. | 11-15-2012 |
20120301966 | Microchip for Platelet Examination and Platelet Examination Device Using Same - A microchip for measuring platelet function by allowing blood to flow through a channel to induce platelet aggregation, wherein the microchip comprises a channel provided inside thereof, wherein at least a part of the channel is coated with collagen for allowing adhesion of platelets; a plurality of walls extend along the direction of the flow of blood in the channel and divide the width of the channel to form a channel dividing section; and the walls are treated to have a surface roughness (Ra) of 10 to 200 nm. | 11-29-2012 |
20130065317 | SAMPLE ANALYZER - A sample analyzer comprising: a sample preparing section for preparing first and second measurement sample including reagent and sample; a first detector for detecting a predetermined component in the first measurement sample prepared by the sample preparing section; a second detector for detecting the predetermined component in the second measurement sample prepared by the sample preparing section; and a controller configured for performing operations, comprising: (a) controlling the first detector to detect the predetermined component in the first measurement sample prepared by the sample preparing section; (b) determining the reliability of the result detected by the first detector; (c) controlling the sample preparing section to prepare the second measurement sample from the same sample when the result has been determined to be unreliable; and (d) controlling the second detector to detect the predetermined component in the second measurement sample, is disclosed. | 03-14-2013 |
20130137182 | BLOOD PRE-TREATMENT APPARATUS AND PRE-TREATMENT METHOD USING THE SAME - Provided is a blood pre-treating apparatus including an injecting part for injecting a blood sample, an albumin-removing part including albumin adsorption beads for removing albumins from the blood sample, and an agglutination part including an agglutination reactant, by which blood corpuscles in the blood sample may be agglutinated to form a hemagglutination reactant. | 05-30-2013 |
20130164854 | DISPOSABLE CARTRIDGE FOR FLUID ANALYSIS - A disposable blood analysis cartridge for analyzing a blood sample including an optical absorbance measurement channel is described. The optical absorbance measurement channel includes a plasma separation region and at least one sub channel including a cuvette that is in fluid communication with the plasma separation region and configured to receive a plasma portion of a blood sample that has been passed through the plasma separation region. A negative pressure may be applied to the cartridge to draw the sample through the plasma separation region and into the sub channel including the cuvette. | 06-27-2013 |
20130196442 | Liquid Reagent Containing Microchip and Method of Using the Same, and Packaged Liquid Reagent Containing Microchip - Provided is a liquid reagent containing microchip having a fluid circuit formed of a space inside thereof. Liquid present in the fluid circuit is transferred to a desired position in the fluid circuit by applying centrifugal force. The fluid circuit includes a reagent retaining portion for accommodating a liquid reagent. The microchip includes an air introduction path formed of a groove provided on an outer surface of the microchip and coupled to the reagent retaining portion for introducing air into the reagent retaining portion, and a sealing portion provided so as to be detachable from the microchip for sealing the air introduction path. A method of using the microchip and a packaged liquid reagent containing microchip using the microchip are also provided. | 08-01-2013 |
20130203175 | AUTOMATED PLATELET FUNCTION ANALYZER AND ITS ANALYTICAL METHODS - An automated platelet function analyzer includes a sampling vessel, a preparation vessel, an analysis vessel, a sampling needle, a blood sample syringe, a platelet agonist syringe, an analysis solution syringe and a blood mixing device. A method for platelet analysis is also disclosed. | 08-08-2013 |
20130210156 | Uniform, Functionalized, Cross-Linked Nanostructures for Monitoring pH - Described herein are optical agents, including compositions, preparations and formulations, for monitoring the pH of a fluid. Optical agents described herein include photonic nanostructures and nanoassemblies including supramolecular structures, such as shell cross-linked micelles, that incorporate at least one linking group comprising one or more photoactive moieties that provide functionality as exogenous agents for a range of pH monitoring applications. Optical agents described herein comprise supramolecular structures having linking groups imparting useful optical and structural functionality. In an embodiment, for example, the presence of linking groups function to covalently cross link polymer components to provide a cross-linked shell stabilized supramolecular structure, and also impart useful optical functionality, for example by functioning as a fluorophore. | 08-15-2013 |
20130316461 | SAMPLE ANALYZER, SAMPLE CONTAINER FOR QUALITY CONTROL, QUALITY CONTROL METHOD - A sample analyzer comprises a sample analysis unit which analyzes a sample, a reading unit which reads information from a storage medium attached to a container that contains a quality control sample, a display, and a controller which displays on the display an analysis result obtained by another sample analyzer and read from the storage medium and an analysis result obtained by the sample analysis unit, when the storage medium stores the analysis result obtained by the other sample analyzer. | 11-28-2013 |
20130330828 | MINIATURIZED MAGNETIC FLOW CYTOMETRY - A measuring device for magnetic flow cytometry has a microfluidic channel disposed along an enriching route such that a magnetically marked cell sample flowing through the microfluidic channel is aligned to magnetic guide strips, enriched by the magnetic field of a magnet at the floor of the channel, and guided past a sensor. The sensor and the magnetic guide strips are integrated on a semiconductor chip. | 12-12-2013 |
20130337567 | NANOWIRE FIELD-EFFECT TRANSISTOR BIOSENSOR WITH IMPROVED SENSITIVITY - The present invention is directed to a multiwire nanowire field effect transistor (nwFET) device for the measurement. The device includes a sensing nanowire having a first end and a second end and a nanowire FET having a first end and a second end, wherein the first end of the sensing nanowire is connected to the nanowire FET to form a node. Additionally, the first end of the nanowire FET is connected to a source electrode, the second end of the nanowire FET is connected to a drain electrode, and the second end of the sensing nanowire is connected to a base electrode. The sensing nanowire is derivatized with a plurality of immobilized capture probes that are specific for a target(s) of interest. The device is used to detect biomolecules or to detect the change in the ionic environment of a sample. In a further embodiment, the sensing nanowire is derivatized with amino, carboxyl or hydroxyl groups. Upon a change in ionic environment, or binding of a molecule to the sensing nanowire, the sensing nanowire current (I | 12-19-2013 |
20130344605 | METHOD AND ARRANGEMENT FOR PARTIAL LABELING AND SUBSEQUENT QUANTIFICATION OF CELLS OF CELL SUSPENSION - Cells of a cell suspension are labeled by providing a microfluidic chamber having superparamagnetic labeling particles that are concentrated exactly at one inner surface of the chamber and charging the cell suspension into the chamber. | 12-26-2013 |
20140051174 | NANOFLUIDIC PLATFORM FOR SINGLE MITOCHONDRIA ANALYSIS - A microfluidic device for mitochondria analysis includes an inlet coupled to a first access channel, an outlet coupled to a second access channel, and a plurality of trapping channels fluidically coupled at one end to the first access channel and fluidically coupled at an opposing end to the second access channel, each trapping channel comprises a cross-sectional dimension about 2 μm in one direction and a cross-sectional dimension between about 0.45 and about 0.75 μm in a second direction. | 02-20-2014 |
20140093967 | SPECIMEN TRANSPORTER, SPECIMEN TESTING SYSTEM AND SPECIMEN TRANSPORTING METHOD - A specimen transporter for transporting a specimen plate, one side of which is a smearing surface, to a specimen imaging apparatus, the specimen transporter comprising: a specimen transport section that transports the specimen plate to the specimen imaging apparatus; a posture changing section that receives the specimen plate from the specimen imaging apparatus with the smearing surface facing upward, and changes the posture of the specimen plate so that one end side in a longitudinal direction of the received specimen plate is positioned above the other end side; and a specimen inserting section that inserts the specimen plate, which posture is changed, into a plate storage rack. | 04-03-2014 |
20140147924 | Apparatus and Method for the Remote Sensing of Blood in Human Feces and Urine - The apparatus and method for detecting blood in urine or feces includes a photodetector configured to detect a transient light emitted in a toilet bowl by luminol and an oxidizer catalyzed by iron in the blood. The apparatus may include dispensers for the luminol, the oxidizer and a base. The apparatus may include a microprocessor and a network connection and may perform statistical analyses, store data and alert the patient or a healthcare provider if blood is detected. The photodetector may be configured to detect light emitted in the toilet bowl by a fluorophore present in the water and excited by the transient light from the luminol and oxidizer. | 05-29-2014 |
20140154810 | METHOD FOR CONDUCTING PLATELET AGGREGATION ANALYSIS - A cartridge device having a receiving portion for receiving a blood sample and a jack portion for receiving a plug; a stirring device for circulating the blood sample within the receiving portion; and an electrode holder having at least one incorporated electrode wire pair; wherein the electrode holder is attachable to the cell such that one end of the at least one electrode wire pair forms a sensor unit for measuring the electrical impedance between the two electrode wires of the at least one electrode wire pair within the blood sample and that the opposite end of the at least one electrode wire pair forms a plug portion being connectable directly to the plug for an electrical connection of the sensor unit to an analyser. | 06-05-2014 |
20140220694 | METHODS AND COMPOSITIONS RELATING TO PLATELET SENSITIVITY - The invention identifies and describes proteins that are differentially expressed in platelets resistant to anti-platelet agents such as aspirin (acetylsalicyclic acid) compared to those platelets that are sensitive to such agents. Methods for determining further such differentially expressed proteins and methods for determining an individual's sensitivity to anti-platelet agents, such as aspirin, prior to administration. | 08-07-2014 |
20140273247 | METHODS FOR MONITORING CHANGES IN THE CORE OF LIPOPROTEIN PARTICLES IN METABOLISM AND DISEASE - A method is disclosed for measuring the properties of protein and lipoprotein elements in a sample. The method includes the of placing a small volume of a sample into a NMR instrument tuned to measure a particular nucleus, applying a series of radiofrequency pulses with intermittent delays in order to measure spin-spin and/or spin-lattice relaxation time constants from the time-domain decay of the signal, without the use of chemical shifts and without converting data into the frequency domain by Fourier transform or other means, at least partially suppressing the water signal prior to the beginning of a sequence used to record relaxation time constants in the time domain, optionally utilizing relaxation contrast agents or other chemical additives to perturb the solvent water or other elements of the sample, analyzing the exponentially decaying NMR signal in the time domain using multi-exponential analysis, and comparing differences in the relaxation time constants for lipoprotein- or protein-specific elements within a single human subject, or between subjects, to assess normal and abnormal metabolism reflective of increased disease risk or active disease. | 09-18-2014 |
20140329329 | FLUID STOP FOR MEASURED SAMPLE CONTAINMENT - A test cartridge includes an input channel to receive a liquid sample to be tested. A sample chamber is coupled to the input channel to receive the sample. An air permeable membrane is coupled between the sample chamber and ambient to prevent passage of the sample past the membrane and stop movement of the sample in the sample chamber. | 11-06-2014 |
20150338330 | Method for Comprehensive Assessment of Platelet Aggregation - A method for comprehensively and quantitatively analyzing platelet aggregability, and stability and persistence of platelet aggregates, which method comprises the steps of: reacting a platelet-activating reagent with blood in a closed container; injecting a liquid which is not mixable with blood into the container using a pump connected to a first end of the container, thereby pushing the mixture of the platelet-activating reagent and the blood out from the container and allowing the mixture to pass through a filter in a filter device connected to a second end of the container; and measuring the pressure exerted on the pump. | 11-26-2015 |
20150338424 | APPARATUS AND METHOD FOR PLATELET FUNCTION AND DRUG REPSONSE TESTING BASED ON MICROFLUIDIC CHIP - The present invention relates to an apparatus and a method for testing a function and a drug response of a platelet based on a microfluidic chip. The apparatus for test comprises a measuring device containing a blood sample and measuring aggregation and adhesion of a platelet generated by flow of the blood sample; and a fluid driving device which is connected to the measuring device and generates a oscillating shear flow of the blood sample. Therefore, activation of factors such as a platelet and von Willebrand factor (vWF) etc. can be activated uniformly and completely, and a repeatability of the platelet aggregation can be increased. | 11-26-2015 |
20150346099 | Uniform, Functionalized, Cross-Linked Nanostructures for Monitoring pH - Described herein are optical agents, including compositions, preparations and formulations, for monitoring the pH of a fluid. Optical agents described herein include photonic nanostructures and nanoassemblies including supramolecular structures, such as shell cross-linked micelles, that incorporate at least one linking group comprising one or more photoactive moieties that provide functionality as exogenous agents for a range of pH monitoring applications. Optical agents described herein comprise supramolecular structures having linking groups imparting useful optical and structural functionality. In an embodiment, for example, the presence of linking groups function to covalently cross link polymer components to provide a cross-linked shell stabilized supramolecular structure, and also impart useful optical functionality, for example by functioning as a fluorophore. | 12-03-2015 |
20150355167 | APPARATUS AND METHOD FOR TESTING MULTI-FUNCTION AND DRUG RESPONSE OF CENTRIFUGAL MICROFLUIDIC-BASED PLATELETS - The present invention relates to an apparatus and method for testing a multi-function and a drug response of platelet based on a centrifugal microfluidics. The testing apparatus according to the present invention may include: a rotatable disk; a sample chamber arranged at the center of the disk such that a blood sample is accommodated therein; stirring chambers respectively connected to the sample chamber in multiple radial directions so as to introduce a shear flow in the blood sample; microchannels connected to the stirring chambers such that adhesion and cohesion of platelets occur during the | 12-10-2015 |
20160074860 | DEVICES AND METHODS FOR CAPTURING TARGET MOLECULES - Provided herein are devices and methods for the capture or isolation of a biomarker from a biological sample. In several embodiments, the device comprises a loading region, a filter material, and a receiving region. In particular, in several embodiments, biological fluid is passed from the loading region through the filter material and into the receiving region, thereby resulting in capture or isolation of a biomarker. | 03-17-2016 |
20160187345 | METHODS FOR DETECTING AND DETERMINING LEVELS OF MONOLIGNOL ESTER CONJUGATES INCORPORATED INTO LIGNIN AND COMPOUNDS RELATING THERETO - Described is a method of detecting and/or determining levels of incorporation of monolignol ferulate conjugate esters into lignin by derivatizing the lignin, reductively cleaving the lignin, labeling the cleavage products, and then detecting cleavage products derived from monolignol ester conjugates via differential attachment of the label. | 06-30-2016 |
20190145963 | PERFORMING OPTICAL MEASUREMENTS ON A SAMPLE | 05-16-2019 |
20220137031 | HEMOLYSIS DETECTION BLOOD TESTING DEVICE - A blood testing assembly and method are described. In the method, a blood testing device having a plasma separation membrane and a reagent is connected to a syringe containing blood having blood cells and plasma. A blood sample of the blood is passed from the syringe through a plasma separation membrane within the blood testing device to separate the plasma from the blood cells. A reagent is saturated with the plasma, and then the reagent is colorimetrically analyzed to determine a degree of hemolysis within the blood sample. | 05-05-2022 |