Class / Patent application number | Description | Number of patent applications / Date published |
436524000 | Carrier is inorganic | 65 |
20090124025 | Nanowire-based sensor configurations - This invention provides nanowire based molecular sensors and methods for detecting analytes in a microfluidic system. Methods for sensing analytes include detecting changed electrical parameters associated with contact of a nanowire with the analyte in a microfluidic system. Sensors of the invention include nanowires mounted in microchambers of a microfluidic system in electrical contact with the detector, whereby electrical parameter changes induced in the nanowire by the analyte can be monitored by the detector. | 05-14-2009 |
20090124026 | Use of Perfluoropolymer Submicrometric Latexes in the Determination of Molecular Interactions By Laser Light Scattering (Lls) - Use of a latex of perfluorinated polymers having particles with an average diameter between 5 and 200 nm for determining the binding constant of two interacting molecular species by Laser Light Scattering (LLS), said polymeric particles comprising on the surface an amphiphilic non ionic surfactant, the same or a different surfactant ended with a receptor and a ligand interacting with the receptor. | 05-14-2009 |
20100081216 | METHOD AND DEVICE FOR RAPID PARALLEL MICROFLUIDIC MOLECULAR AFFINITY ASSAYS - Disclosed are methods and devices for rapid parallel molecular affinity assays performed in a microfluidic environment. The invention exploits hydrodynamic addressing to provide simultaneous performance of multiple assays in parallel using a minimal sample volume flowing through a single channel. | 04-01-2010 |
20100190270 | SYSTEM AND METHODS FOR DETECTING A GASEOUS ANALYTE IN A GAS - Systems and methods for detecting a gaseous analyte utilize a micromechanical piezoelectric resonator having a functionalization layer configured to bind with the gaseous analyte. The functionalization layer may include a layer of carbon nanotubes affixed to the resonator and coated with biopolymers configured to bind with the gaseous analyte. The gaseous analyte may be detected by operating the micromechanical piezoelectric resonator and functionalization layer in the presence of the gas, detecting a change in the resonant frequency of the resonator, and determining the concentration of the gaseous analyte from the change in resonant frequency. Finally, the layer of carbon nanotubes may be grown on the piezoelectric resonator by depositing a catalyst on a piezoelectric structure, heating the piezoelectric structure and the catalyst to enhance the growth of the carbon nanotubes, and growing the carbon nanotubes at growth sites on the piezoelectric structure. | 07-29-2010 |
20100216256 | NANOBELT-BASED SENSORS AND DETECTION METHODS - A biosensor is provided which includes a substrate, a source electrode on the substrate, a drain electrode on the substrate, and at least one functionalized nanobelt on a surface of the substrate between the source electrode and the drain electrode. Methods for sensing a biological or chemical analyte using the sensor is also provided. | 08-26-2010 |
20100291711 | INTEGRATED SENSOR MICROSYSTEM AND METHOD FOR DETECTING BIOMOLECULES IN LIQUID - An integrated microsystem for detecting biomolecules is made up of a micropump for delivering a sample, a microsensor for detecting the presence of a target biomolecule in the sample, a microheater for maintaining the temperature of operation, a microcontroller for regulating the sample delivery and a signal processor for analyzing the sensor signal. A single wall carbon nanotube based biological sensor can be used as the microsensor. The single wall carbon nanotube based sensor can either have a chance in conductance based on the presence and/or quantity of the target biomolecule or quantify the mass uptake of the sensor matrix. | 11-18-2010 |
20120178187 | MAGNETIC CARBON NANOTUBE BASED BIODETECTION - Provided herein is a new hybrid material system, mCNT, including magnetic carbon nanotubes for biological and medical sensing applications. In certain embodiments, the systems include magnetic material on the interior of carbon nanotubes (CNTs). The amount of magnetic particles inside CNTs may be such that mCNT can respond to small, low cost, portable magnet. The exterior CNT surface is kept intact for biomolecular attachments or other functionalizations. Performance enhancement with this novel material includes improved sensitivity, reduced response time, and reduced sample volume. According to various embodiments, the mCNTs are substrates for the adherence of molecules participating in these assays or as active sensing elements. Also provided are methods of fabricating two-dimensional mCNT and CNT networks on printed electrodes. | 07-12-2012 |
436525000 | Metal or metal coated | 55 |
20080206890 | BIS(2,9-DI-TERT-BUTYL-1,10-PHENANTHROLINE)COPPER(I) COMPLEXES, METHODS OF SYNTHESIS, AND USES THEROF - The present invention provides homoleptic and heteroleptic copper(I) complexes having sterically demanding ligands, such as the bis(2,9-di-tert-butyl-1,10-phenanthroline)copper(I) complex and related complexes, methods of synthesis of these complexes and uses thereof. These copper(I) complexes are useful for various applications including photovoltaic cells, light-emitting electrochemical cells, and analyte sensor systems. | 08-28-2008 |
20080213919 | Functionalized fluorescent nanocrystals, and methods for their preparation and use - Functionalized fluorescent nanocrystal compositions and methods for making and using these compositions are disclosed. The compositions are fluorescent nanocrystals coated with at least one material. The coating material has chemical compounds or ligands with functional groups or moieties with conjugated electrons and moieties for imparting solubility to coated fluorescent nanocrystals in aqueous solutions. The coating material provides for functionalized fluorescent nanocrystal compositions which are water soluble, chemically stable, and emit light with a high quantum yield and/or luminescence efficiency when excited with light. The coating material may also have chemical compounds or ligands with moieties for bonding to target molecules and cells as well as moieties for cross-linking the coating. In the presence of reagents suitable for reacting to form capping layers, the compounds in the coating may form a capping layer on the fluorescent nanocrystal with the coating compounds operably bonded to the capping layer. | 09-04-2008 |
20080261328 | Method of preventing precipitation of a reactive substance-bound microparticle, and reagent containing the micro particle - According to the present invention, precipitation of a reactive substance-bound microparticle can be prevented in a dispersion liquid, to make a concentration of the reactive substance-bound microparticle uniform in the dispersion liquid. The present invention provides a method of preventing precipitation of a reactive substance-bound microparticle. The method includes coexisting at least one selected from the group consisting of polyanion or its salt, dextran, cyclodextrin, polyethylene glycol, and glycerol, with the microparticle in a dispersion liquid. | 10-23-2008 |
20090075396 | Biosensors - Methods for detecting a biological interaction comprising administering a substrate comprising a ligand attached to the substrate wherein the ligand binds to a receptor and wherein a signal is produced. Also disclosed is a biosensor comprising a substrate and a ligand wherein the ligand is attached to the surface of the substrate and wherein the ligand preferentially binds to a receptor. | 03-19-2009 |
20090098662 | DETERMINING THE PRESENCE OR AMOUNT OF A METAL-LABELLED SPECIES - A method for determining the presence or amount of a metal-labelled species in a sample may include causing the metal of the metal-labelled species in the sample to form a soluble electrochemically-active complex which is stable relative to moieties present or potentially present in the sample which will form an insoluble and/or electrochemically-inactive complex with the metal, and electrochemically measuring the formed complex to provide an indication of the presence or amount of the metal-labelled species. | 04-16-2009 |
20090098663 | NOVEL WATER-SOLUBLE NANOCRYSTALS COMPRISING A POLYMERIC COATING REAGENT, AND METHODS OF PREPARING THE SAME - Disclosed is a water soluble nanocrystal comprising a nanocrystal core comprising at least one metal M1 selected from an element of main group II, subgroup VIIA, subgroup VIIIA, subgroup IB, subgroup IIB, main group III or main group IV of the periodic system of the elements (PSE), at least one element A selected from main group V or main group VI of the PSE, a capping reagent attached to the surface of the core of the nanocrystal, and a water soluble polymer covalently coupled with the capping reagent to form a water soluble polymer shell over the nanocrystal core. Also disclosed are compositions comprising such nanocrystals and uses of such nanocrystals. | 04-16-2009 |
20090117669 | SUBSTRATE FOR TARGET SUBSTANCE DETECTING DEVICE, TARGET SUBSTANCE DETECTING DEVICE, TARGET SUBSTANCE DETECTING APPARATUS AND METHOD USING THE SAME, AND KIT THEREFOR - A substrate for forming a target substance detecting device includes a supporting member, an underlying layer disposed on a surface of the supporting member, and a metal pattern layer, disposed on a surface of the underlying layer, for being bound to a target substance trapping substance capable of trapping a target substance in a specimen solution at least containing water as a liquid medium to detect the target substance by utilizing plasmon resonance. The underlying layer has a refractive index nb satisfying the following relationship: | 05-07-2009 |
20090203153 | METAL PARTICLE AND A TESTING METHOD USING THE SAME - An object of the present invention is to provide a metal particle with which a highly-sensitive testing method can be conducted, and a testing method using such metal particle. The present invention provides a metal particle, which is produced by coating a metal particle labeled with a molecule binding to an analyte with a mixture of two or more types of water-soluble polymer having a mercapto group, a dithiol group or a sulfide group and differing in molecular weight. | 08-13-2009 |
20090233380 | Methods and Compositions of Conjugating Gold to Biological Molecules - The present application describes methods for conjugating gold to biological molecules and conjugates resulting from the same. The method provides superior gold conjugated biomolecules with higher sensitivity than those made from conventional gold conjugation methods. | 09-17-2009 |
20090311806 | GOLD-BINDING PROTEIN AND USE THEREOF - A protein utilizing an anti-gold antibody and a gold-binding side which is a part of the anti-gold antibody is constructed. This protein is capable of specifically binding to gold. This protein or a complex protein containing such a protein can be used for the detection of a target substance. | 12-17-2009 |
20090325316 | Compositions for use as a Signal Generation Component and Methods of Using Same - Compositions suitable for use as signal generation components of an immunoassay, and methods for their use. According to one aspect of the invention, the composition includes a carrier having a coating of an aminodextran and a metal chelate incorporated therein. The metal chelate is present in the amount of at least 0.065 μM per milligram of carrier, and the aminodextran coating density averaging at least about 45 μg per milligram of carrier. In another aspect of the invention, carrier is dyed with a complex having the formula: | 12-31-2009 |
20100062545 | BIOASSAYS USING PLASMONIC SCATTERING FROM NOBLE METAL NANOSTRUCTURES - The present invention relates to detecting and/or measuring scattering effects due to the aggregating metallic nanostructures or the interaction of plasmonic emissions from approaching metallic nanoparticles. The scattering effects may be measured at different angles, different wavelengths, changes in absorption and/or changes in polarization relative to changes in the distances between nanoparticles. | 03-11-2010 |
20100075441 | RAPID IMMUNOCHROMATOGRAPHIC DETECTION BY AMPLIFICATION OF THE COLLOIDAL GOLD SIGNAL - The present invention relates to a method for rapid immunochromatographic detection of a target in a sample, wherein the target is an antibody and/or an antigen, using different colloidal gold conjugates conjugated with a specific antibody and some oligonucleotides and their complementary oligonucleotides and/or antibodies and their related antigens, rapid immunochromatographic detection devices, uses of the method for detecting diseases or specific conditions, and a method for the manufacture of the devices as well as a kit which comprises the devices. | 03-25-2010 |
20100087013 | Nanosensors and related technologies - The present invention generally relates to nanotechnology and sub-microelectronic circuitry, as well as associated methods and devices, for example, nanoscale wire devices and methods for use in determining nucleic acids or other analytes suspected to be present in a sample (for example, their presence and/or dynamical information), e.g., at the single molecule level. For example, a nanoscale wire device can be used in some cases to detect single base mismatches within a nucleic acid (e.g., by determining association and/or dissociation rates). In one aspect, dynamical information such as a binding constant, an association rate, and/or a dissociation rate, can be determined between a nucleic acid or other analyte, and a binding partner immobilized relative to a nanoscale wire. In some cases, the nanoscale wire includes a first portion comprising a metal-semiconductor compound, and a second portion that does not include a metal-semiconductor compound. The binding partner, in some embodiments, is immobilized relative to at least the second portion of the nanoscale wire, and the size of the second portion of the nanoscale wire may be minimized and/or controlled in some instances. Articles and devices of size greater than the nanoscale are also included in certain embodiments. Still other aspects of the invention include assays, sensors, kits, and/or other devices that include such nanoscale wires, methods of making and/or using such nanoscale wires, or the like. | 04-08-2010 |
20100178713 | TARGET SUBSTANCE-DETECTING ELEMENT - A substrate of a target substance-detecting element for detecting a target substance in a specimen based on localized surface plasmon resonance comprises a supporting member and a metal nano-dot group provided on the supporting member, metal nano-dots each of which is comprised in the metal nano-dot group and adjacent to each other are arranged with a gap between the metal nano-dots of not larger than 30 nm. | 07-15-2010 |
20100233825 | CHEMICAL SENSOR ELEMENT, SENSING APPARATUS, AND SENSING METHOD - A chemical sensor element contains a resonator having a first reflector in which particles of a fine metal structure are arranged two-dimensionally and periodically is counterposed with interposition of a dielectric layer to a second reflector, wherein the resonance wavelength of a resonator in which the entire of the first reflector is replaced by a metal thin film having the same thickness as the metal fine structure is different from the surface plasmon resonance wavelength induced in the metal fine structure; and the mode of the surface plasmon resonance excited in the metal fine structure is coupled with the mode of the resonator in which the entire of the first reflector is replaced by the metal thin film. | 09-16-2010 |
20100304502 | DETECTION METHOD AND DETECTION KIT - A detection method for detecting a substance such as a virus which achieves enhanced detection sensitivity even in trace amounts of a substance to be detected and is also simple and superior in visual determinability is disclosed, comprising contacting a complex of a substance to be detected and a semiconductor nanoparticle-labeled probe capable of bonding the substance with an immobilized capture reagent capable of bonding the substance to detect the substance. A detection kit is also disclosed. | 12-02-2010 |
20110014724 | METHOD OF DETECTING BIOPRODUCTS USING LOCALIZED SURFACE PLASMON RESONANCE SENSOR OF GOLD NANOPARTICLES - Disclosed is a method of detecting bioproducts using Localized Surface Plasmon Resonance (LSPR) of gold nanoparticles, which can diagnose bioproducts based on changes in the maximum wavelength occurred by an antigen-antibody reaction after immobilization of the gold nanoparticles onto a glass panel. A sensor using such method exhibits high sensitivity, is low in price, and makes quick diagnosis possible, thereby being applicable to various biological fields associated with environmental contaminants, pathogens and the like, as well as diagnosis of diseases. Further, it provides a technology for manufacturing a sensor having higher sensitivity, low price and quick performance, as compared to conventional methods using SPR. | 01-20-2011 |
20110045607 | PROBE COMPOSITE, METHOD FOR MANUFACTURING THE SAME, METHOD FOR USING THE SAME, AND CONTRAST AGENT INCLUDING THE SAME - A probe composite for photoacoustic imaging includes a first probe and the second probe mixed with each other. The first probe includes a first ligand and a first nanorod conjugated to the first ligand. The first ligand specifically interacts with a first target. The second probe includes a second ligand and a second nanorod conjugated to the second ligand. The second ligand specifically interacts with a second target. | 02-24-2011 |
20110124131 | METHOD FOR PREPARING METAL NANOPARTICLE USING METAL BINDING PROTEIN - The present invention relates to a method of preparing heavy metal nanoparticles using a heavy metal-binding protein. More specifically, relates to a method for preparing heavy metal structures, comprising the steps of: culturing a microorganism transformed with a gene encoding a heavy metal-binding protein, in a heavy metal ion-containing medium, to produce heavy metal structures in the microorganism; and collecting the produced heavy metal structures, as well as nanoparticles of heavy metal structures prepared according to said method. Unlike prior methods of preparing quantum dots by physically binding metal materials, en the quantum dots disclosed herein can be efficiently produced by expressing the heavy metal-binding protein in cells. In addition, the quantum dots are useful because they can solve an optical stability problem that is the shortcoming of organic fluorophores. | 05-26-2011 |
20110124132 | CENTRIFUGAL MICRO-FLUIDIC DEVICE AND METHOD FOR DETECTING TARGET IN FLUID SAMPLE - Disclosed are a centrifugal micro-fluidic device and an immunosorbent assay method using the same. In particular, a centrifugal micro-fluidic device having a plurality of micro-fluidic structures placed in a disc type platform to simultaneously conduct several immunosorbent assays, as well as an immunosorbent assay method using the same are provided. | 05-26-2011 |
20110294230 | Lyophilization of Colloidal Metals for Surface Enhanced Raman Scattering - An assay and method of making same for use in SERS spectroscopy. The assay includes colloidal particles of a metal, which have been lyophilized. The lyophilized particles of metal produce a SERS active solution when reconstituted. The lyophilized particles of metal may be provided in a container in an assay system. | 12-01-2011 |
20120028372 | RAPID DETECTION AND IDENTIFICATION OF ENERGETIC MATERIALS WITH SURFACE ENHANCED RAMAN SPECTROMETRY (SERS) - In one embodiment, a system includes a plurality of metal nanoparticles functionalized with a plurality of organic molecules tethered thereto, wherein the plurality of organic molecules preferentially interact with one or more analytes when placed in proximity therewith. According to another embodiment, a method for detecting analytes includes contacting a fluid having one or more analytes of interest therein with a plurality of metal nanoparticles, each metal nanoparticle having a plurality of organic molecules tethered thereto, and detecting Raman scattering from an analyte of interest from the fluid, the analyte interacting with one or more of the plurality of organic molecules. In another embodiment, a method includes chemically modifying a plurality of cyclodextrin molecules at a primary hydroxyl moiety to create a chemical handle, and tethering the plurality of cyclodextrin molecules to a metal nanoparticle using the chemical handle. Other systems and methods for detecting analytes are also described. | 02-02-2012 |
20120171782 | MASS SPECTROMETRIC IMMUNOASSAY - Rapid mass spectrometric immunoassay methods for detecting and/or quantifying antibody and antigen analytes utilizing affinity capture to isolate the analytes and internal reference species (for quantification) followed by mass spectrometric analysis of the isolated analyte/internal reference species. Quantification is obtained by normalizing and calibrating obtained mass spectrum against the mass spectrum obtained for an antibody/antigen of known concentration. | 07-05-2012 |
20120184052 | Isolation and Analysis of Thiol Protein Matter Using Gold Nano-Particles - A method of rapidly and accurately identifying and analyzing thiol proteins in a sample using gold nanoparticles. Disclosed are embodiments of a flow device for isolation, fractionation and subsequent instrumental analysis of thiol containing proteins from various samples or tissue sources using gold nanoparticles. Also disclosed are embodiments of a flow device for detecting, isolating and fractionating S-nitrosated proteins and peptides for subsequent analysis, including identification of S-nitrosation sites. | 07-19-2012 |
20130224886 | FLOW RATE MEASUREMENT APPARATUS, ANTIGEN CONCENTRATION MEASUREMENT APPARATUS, FLOW CELL, FLOW RATE MEASUREMENT METHOD, AND ANTIGEN CONCENTRATION MEASUREMENT METHOD - A flow rate measurement apparatus includes a light oscillator; a thin metallic film which causes surface plasmon resonance by light output from the light oscillator; a focusing unit which fixes the thin metallic film and converts the output light of the light oscillator into incident light having a plurality of incident angles to focus the incident light at a location of a focal line in a straight line shape on the thin metallic film; a measurement part having antibody fixed areas to which an antibody is fixed and reference areas to which an antibody is not fixed, the antibody fixed areas and the reference areas being alternately arranged at a location along the focal line location on the thin metallic film; a light receiver which receives reflected light, at the focal line location, of the output light by surface plasmon resonance occurring at the focal line location, at each of the plurality of incident light angles; an SPR angle calculator which obtains a temporal change of an SPR angle in each of the antibody fixed areas and the reference areas in the measurement part; and a flow rate operation unit which calculates the flow rate of the sample flowing in the flow cell based on the temporal change of the SPR angle obtained by the SPR angle calculator. | 08-29-2013 |
20160033499 | BIOSAMPLE PLATE WITH DATA STORAGE AND WIRELESS COMMUNICATIONS - Embodiments of the disclosure relate to a biosample plate that includes a memory component for storing biosample identification and analysis data, and a wireless communication interface for transferring the data to and from the biosample plate. In one embodiment, the biosample plate comprises a base for receiving a biosample, a memory component coupled to the base for storing identification and analysis information related to the biosample, and a wireless communication interface coupled to the memory component for transferring the information to and from the memory component. The wireless communication interface may include an optical device. | 02-04-2016 |
436526000 | Magnetic | 28 |
20080206891 | Synthetic antiferromagnetic nanoparticles - The present invention provides a synthetic antiferromagnetic (SAF) nanoparticle. The SAF nanoparticle includes at least two ferromagnetic layers and at least one non-magnetic spacer layer. The spacer layer is situated in between planar surfaces of the ferromagnetic layers. The saturation field of the SAF nanoparticle is tunable by the geometry and composition of the nanoparticle. Preferably, the saturation field can be tuned to be between about 100 Oe and about 10,000 Oe. Also preferably, the SAF nanoparticle has a magnetic moment of at least 800 emu/cm | 08-28-2008 |
20080206892 | Rapid Magnetic Biosensor With Integrated Arrival Time Measuremnt - The invention provides a method, a device and a system for determining a concentration of at least one sort of polarizable or polarized magnetic labels in a fluid, the sensing surface comprising at least one sort of binding sites capable of specifically attaching to at least one sort of biological entities linked to the magnetic labels, the sensing device further comprising at least one magnetic sensor element, the sensing device further comprising first means for determining the concentration of magnetic labels attached to the binding sites and second means for determining the time of arrival of the fluid. | 08-28-2008 |
20080241964 | MATERIAL FOR IMPROVING SENSITIVITY OF MAGNETIC SENSOR AND METHOD THEREOF - The present invention relates to a capture agent member being used in a magnetic sensor to detect the presence or concentration of a target substance in a test solution by detecting the presence or number of the magnetic marker, wherein the capture agent member contains a capture agent for capturing the target substance and a labeling agent serving as a nucleus for the magnetic marker to agglutinate, and wherein the capture agent is labeled with the labeling agent. The present invention relates to a material which improves detection sensitivity of a biosensor using a magnetic sensor while maintaining reactivity and dispersibility. In particular, according to the present invention, there can be provided a material which enables realization of high sensitivity by using a simple magnetic biosensor such as a semiconductor Hall element and a magnetoresistance effect element. | 10-02-2008 |
20080261329 | Method of analysis of a mixture of biological and/or chemical components with the use magnetic particles and apparatus for its embodiment - Technical field: analysis of mixtures, predominantly of biologic origin, for the contents of biological and/or chemical components, and analysis of mixtures, which parameters determine vital functions of biologic objects. | 10-23-2008 |
20080311677 | SYSTEMS AND METHODS FOR DETECTING TARGET ANALYTES - A method of detecting a target substance includes contacting the target substance with a substrate. The substrate has a first receptor bound to the substrate. The target substance binds to the first receptor. The method further includes contacting a second receptor with the substrate. The second receptor is associated with the target substance. The second receptor is biotinylated. The method also includes contacting an anti-biotin antibody conjugated paramagnetic particle with the substrate. | 12-18-2008 |
20080311678 | SAMPLE ANALYZER AND SAMPLE ANALYZING METHOD - The present invention is to present a sample analyzer which is capable of separate and dispose of the reaction container and the reaction liquid respectively even when magnetic particles are included in a reagent. The sample analyzer | 12-18-2008 |
20080318342 | Diagnostic Testing Process and Apparatus Incorporating Controlled Sample Flow - An apparatus ( | 12-25-2008 |
20090004758 | RESONANT MAGNETIC DISKS FOR BIOANALYTE DETECTION - Embodiments of the invention relate generally to ferromagnetic microdisks, methods of detecting target bioanalyte using ferromagnetic microdisks, and kits (such as for using in the laboratory setting) containing the reagents necessary to make, and/or use ferromagnetic microdisks for bioanalyte detection, depending on the user's planned application. The methods and products allow the fabrication of ferromagnetic microdisks, and their use in the detection of biological molecules with high sensitivity, little or no signal decay, improved safety, convenience, and lowered cost for use and disposal. | 01-01-2009 |
20090117670 | DETECTION OF TARGET MOLECULES IN A SAMPLE BY USING A MAGNETIC FIELD - The application relates to a method for detecting a target in a sample suspected of containing the target. The method comprises contacting the sample and a first binding molecule attached to a magnetic particle with a second binding molecule attached to a solid support. The first binding molecule is capable of binding to the second binding molecule, and the target is capable of interfering with this binding. Magnetic force is applied to bring the magnetic particle into close proximity with the solid support. The number of magnetic particles bound to the solid support is detected. | 05-07-2009 |
20090130778 | Water-Soluble Polymeric Substrate Having Metallic Nanoparticle Coating - A metallic nanoparticle coated water-soluble polymeric substrate and the process for preparing and using the same is described. | 05-21-2009 |
20090191649 | BIOSENSOR AND METHOD OF ASSAYING OBJECT - A biosensor capable of analyzing an object, such as antigen, antibody, DNA or RNA, through detection of magnetic field to thereby allow washout of unbound label molecules to be unnecessary, which biosensor is compact and available at low price, excelling in detection precision. Coils are arranged at an upper part and a lower part of a magnetic sensor using a hall element as a magnetic field detection element. An object and magnetic particles having an antibody capable of specific bonding with the object bound to the surface thereof are introduced in the magnetic sensor having a molecular receptor capable of specific bonding with the object attached to the surface thereof. Therefore, a change in magnetic field by magnetic particles bonded through the molecular receptor to the surface of the magnetic sensor is detected by means of the hall element. At that time, one applied magnetic field is set so that the magnetization intensity of magnetic particles falls within the range from initial magnetic permeability to maximum magnetic permeability while another applied magnetic field is set so that the magnetization intensity of some or all of the magnetic particles becomes saturated, and output signals are compared with each other. Thus, the amount of bonded magnetic particles can be identified. | 07-30-2009 |
20090203154 | Method for Sensing a Chemical - This invention relates to a method for detecting an analyte in a sample. The method comprises the steps of exposing the sample to a transducer having a pyroelectric or piezoelectric element and electrodes which is capable of transducing a change in energy to an electrical signal, the transducer having at least one reagent proximal thereto, the reagent having a binding site which is capable of binding the analyte or a complex or derivative of the analyte, wherein at least one of the analyte or the complex or derivative of the analyte has a label attached thereto which is capable of absorbing the electromagnetic radiation generated by the radiation source to generate energy by non-radiative decay; irradiating the reagent with a series of pulses of electromagnetic radiation, transducing the energy generated into an electrical signal; detecting the electrical signal and the time delay between each pulse of electromagnetic radiation from the radiation source and the generation of the electric signal. The time delay between each of the pulses of electromagnetic radiation and the generation of the electric signal corresponds to the position of the analyte at any of one or more positions at different distances from the surface of the transducer. The label is a nanoparticle comprising a non-conducting core material and at least one metal shell layer. | 08-13-2009 |
20090325317 | METHOD AND SYSTEM FOR SUPPRESSING BINDINGS ON MAGNETIC PARTICLES - A method for suppressing non-specific bindings between molecules includes providing magnetic particles dispersed in a liquid, wherein each of the magnetic particles has a magnetization. The magnetic particles are coated with coating molecules. Binding molecules mixed of first-type binding molecules and second-type binding molecules are applied to the liquid, wherein the coating molecules are specifically binding with the first-type binding molecules and non-specifically binding with the second-type binding molecules. An alternating current (ac) magnetic field is applied at an axis with a frequency level, wherein the frequency level causes suppression of the second-type binding molecules in binding with the coating molecules. | 12-31-2009 |
20090325318 | SUPRA NANOPARTICLE ASSEMBLIES AND METHODS OF MAKING AND USING THE ASSEMBLIES - A method of reporting a binding event having increased sensitivity and multiplex capabilities. A reporter supra-nanoparticle assembly is provided that has an inner core made of a polymeric material, a coating on the inner core made of a polymeric material and a plurality of reporter nanoparticles, and a first active group on the surface of the coating. | 12-31-2009 |
20100055803 | METHOD AND APPARATUS FOR DETECTING MOLECULES - A method and apparatus for detecting a target molecule in a sample are disclosed. The method optionally includes, but is not limited to, contacting the sample with a substrate having a metallic surface and receptors configured to bind to a target molecule, optionally in the presence of one or more metallic nanoparticles also including receptors configured to bind to a target molecule. The method optionally further includes dispersing a dye over the substrate; and applying a magnetic field to the substrate. | 03-04-2010 |
20100120174 | WATER RELAXATION-BASED SENSORS - This invention relates to magnetic resonance-based sensors and related methods. | 05-13-2010 |
20100291712 | MANIPULATION OF MAGNETIC MICROPARTICLES IN A HIGH PRESSURE LIQUID SYSTEM AND EXTRACTION PROCESS - The invention concerns a device and a method for the manipulation of a liquid sample material in which magnetic microparticles are suspended whereby the microparticles have a functionalized surface and an analyte is bound to the surface. The sample material is introduced into a device with a liquid system through an injection device ( | 11-18-2010 |
20100297780 | METHODS AND SYSTEMS FOR DETECTING - A system and method is described wherein components of the reagent ( | 11-25-2010 |
20100323457 | BIOSENSING METHOD USING COATED MAGNETIC FINE PARTICLES AND BIOSENSING APPARATUS FOR BIOSENSING METHOD - An object of the present invention is to provide a novel biosensing method as the novel application development of the magnetic particles in the biosensing. In an affinity reaction of biosensing, ligands are immobilized to magnetic fine particles and the magnetic fine particles are forced to reaction fields of the affinity reaction by magnetic guiding so as to bring the affinity reaction, which is the velocity controlling factor in the sensing, to high rates. According to the present invention, coated magnetic fine particles with having both of the high dispersion performance and high magnetic responsibility as the above described magnetic fine particles and the affinity reaction occurs quickly and in high density such that the present invention makes it possible to obtain relatively large signals within significantly short time duration when compared to the conventional art. | 12-23-2010 |
20110020953 | NMR device for detection of analytes - This invention relates generally to detection devices having one or more small wells each surrounded by, or in close proximity to, an NMR micro coil, each well containing a liquid sample with magnetic nanoparticles that self-assemble or disperse in the presence of a target analyte, thereby altering the measured NMR properties of the liquid sample. The device may be used, for example, as a portable unit for point of care diagnosis and/or field use, or the device may be implanted for continuous or intermittent monitoring of one or more biological species of interest in a patient. | 01-27-2011 |
20110027916 | DETECTION APPARATUS FOR DETECTING PARTICLES - The invention relates to a detection apparatus for detecting particles ( | 02-03-2011 |
20110195526 | Thermo-probes, methods of making thermo-probes, and methods of detection using thermo-probes - Embodiments of the present disclosure provide for thermo-probes (also referred to herein as “probes”), particles including a plurality of probes, methods of making thermo-probes or particles, thermo-probe complexes, method of making thermo-probe complexes, methods of detecting a target, methods of detecting multiple targets, assays using the thermo-probes, immunoassays using the thermo-probes, methods of using thermo-probes or particles, and the like. | 08-11-2011 |
20110223691 | RESONANT MAGNETIC DISKS FOR BIOANALYTE DETECTION - Embodiments of the invention relate generally to ferromagnetic microdisks, methods of detecting target bioanalyte using ferromagnetic microdisks, and kits (such as for using in the laboratory setting) containing the reagents necessary to make, and/or use ferromagnetic microdisks for bioanalyte detection, depending on the user's planned application. The methods and products allow the fabrication of ferromagnetic microdisks, and their use in the detection of biological molecules with high sensitivity, little or no signal decay, improved safety, convenience, and lowered cost for use and disposal. | 09-15-2011 |
20110269249 | DISTRIBUTION OF PARTICLES IN CHAMBER BY APPLICATION OF MAGNETIC FIELD - The present invention relates to a device and a method for clustering and subsequently distributing a plurality of paramagnetic particles in a small volume liquid in a chamber, said chamber having a first wall and an opposite second wall, said method comprising the steps of a) providing a liquid comprising the plurality of paramagnetic particles, b) subjecting the paramagnetic particles to a first magnetic field by means of a first field generating means having first and second mutually spaced opposite poles and defining a first pole axis extending between the poles, the field generating means being arranged relative to the first wall so that the first pole axis (a | 11-03-2011 |
20140017816 | WATER RELAXATION-BASED SENSORS - This invention relates to magnetic resonance-based sensors and related methods. | 01-16-2014 |
20140093982 | MEASUREMENT METHOD AND MEASUREMENT KIT OF ANTIBIOTICS CONCENTRATION - A method and kit for measuring a concentration of an antibiotic are provided. The method of measuring a concentration of an antibiotic includes preparing magnetic particles bound to an antibiotic, preparing silica-coated fluorescent particles to which at least one antibody of the antibiotic is bound, allowing the magnetic particles to react with the silica-coated fluorescent particles, and irradiating the reacted silica-coated fluorescent particles with laser beams. | 04-03-2014 |
20140179025 | PARTICLES - A coated magnetic particle comprising an optionally porous magnetic polymer particle of a matrix polymer, said polymer particle having on a surface and/or in the pores thereof superparamagnetic crystals, said coated particle having a coat formed of a coating polymer, wherein said coated magnetic particle is essentially non-autofluorescent. | 06-26-2014 |
20150140684 | TARGET AFFINITY MATERIAL INCLUDING BIODEGRADABLE POLYMER AND USE THEREOF - A target affinity material comprising a biodegradable polymer, wherein the biodegradable polymer comprises one or more solid particles and one or more materials that specifically binds to a target, as well as related methods and kits. | 05-21-2015 |
436527000 | Glass or silica | 3 |
20080220538 | Novel Cancer Associated Antibodies And Their Use In Cancer Diagnosis - The present invention relates to an antibody having specificity for a polypeptide comprising an amino acid sequence of SEQ ID No:2 or an isoform thereof or a polypeptide comprising SEQ ID NO:2. | 09-11-2008 |
20090246889 | SUBSTRATE HAVING OXIDE LAYER, METHOD FOR DETECTING TARGET MATERIAL USING THE SUBSTRATE, AND OPTICAL SENSOR INCLUDING THE SUBSTRATE - Provided are a substrate used in optically detecting a target material and having an oxide layer, a method for detecting a target material using the substrate, and an optical sensor including the substrate. The substrate can provide an increased detection signal in an analysis method using the substrate. | 10-01-2009 |
20100233826 | Analytical composition and method - An optically detectable analytical composition comprising a rare earth dopant, a carrier incorporating the rare earth dopant, and at least one of: a chemical linker suitable to bind to a biological binding agent and a biological binding agent is disclosed. Preferred embodiments include a glass micro bead carrier treated to attach a biological binding agent such as a protein, or a nucleic acid. The binding agent can bind to a target species in a sample and thereafter be used to determine the presence, concentration or absence of the target in the sample. The composition can be used in a number of different applications, such as to perform fragment analysis of DNA. The narrow bands emitted by rare earth dopants when excited, allows for a large number of such dopants to be incorporated into an individual carrier, allowing detailed characterisation of the sample to be conducted in a reduced number of sample test runs. | 09-16-2010 |