Entries |
Document | Title | Date |
20080206859 | Live bacteria liquid product applicator - An applicator for applying a liquid carrier having live bacteria suspended therein, which are in a dormant state, to a target host comprising a pump having inlet and discharge sides, with the inlet side of the pump being in fluid communication with the liquid carrier. A first fluid conduit extends from the discharge side of the pump to an air induction nozzle which is in communication with a source of air under pressure. A flow control is imposed in the first conduit for adjusting the amount of liquid carrier passing therethrough. The pump and the air supply for the air induction nozzle are operatively connected to a power supply. The pump, when activated, causes the liquid carrier to be pumped to the air induction nozzle wherein the liquid carrier is mixed with air to create small droplets thereof for spraying onto the target host. | 08-28-2008 |
20080213877 | Filtration Device For Biological Samples - An open-topped container ( | 09-04-2008 |
20080248563 | Specimen container for the micro manipulation and biopsy in in-vitro fertilization - A container or dish is useful for the micro manipulation, micro injection, biopsy and fertilization in oocyte and embryo manipulation and culturing. The dish allows the user to more readily perform procedures used to fertilize oocytes by Intracytoplasmic sperm injection (ICSI) or other procedures, biopsy embryos and perform additional procedures for use in assisted reproductive techniques (ART), human reproduction and in-vitro fertilization (IVF). The invention allows ease in use, the reduction in the number of micro tools used in the procedure, as opposed to conventional dishes and procedures, and will allow the user to more readily locate the oocytes and embryos to be handled and worked on. The invention will add repetitiveness, consistency, improve efficacy and ease of procedure and may improve outcomes. The invention will also give the user a more ergonomically practical dish for these types of procedures and related protocols. Specimens other than oocytes and embryos can be treated in the container by means of micro manipulation. | 10-09-2008 |
20080286859 | Apparatus For Producing Thin Sections - An apparatus for producing flat thin sections of a specimen ( | 11-20-2008 |
20080318310 | Method and Apparatus for Automatically Isolating Microbial Species - This invention relates to an apparatus for streaking a sample on a media-coated (agar) plate in a predefined pattern utilizing a plate carousel system to house and retrieve a plate to a fixed location, a streaking mechanism having a floating stylus having a tip capable of gliding over the agar surface and depositing a sample onto the surface of the agar, a sample dispensing system and an optional wash station. | 12-25-2008 |
20090081773 | MICROFLUIDIC APPARATUS FOR MANIPULATING IMAGING AND ANALYZING CELLS OF A CYTOLOGICAL SPECIMEN - A microfluidic apparatus for isolating and imaging or analyzing cells of a cytological specimen includes a substrate and a microfluidic cellular isolation element that includes an outer wall, a channel, a partition member and a receptacle. The partition member is positioned within the isolation element interior, and the receptacle is positioned within the partition member interior. The isolation element is configured such that fluid introduced through the outer wall inlet flows through the channel in a first direction, and the partition member is situated such that fluid flows from the channel into the partition member interior through the partition member inlet aperture in a second direction different than the first direction. The receptacle positioned relative to the partition member inlet to catch and retain a cell carried by the fluid. | 03-26-2009 |
20090081774 | Automated Staining and Decolorization of Biological Material - An improved method and apparatus for staining samples of biological material for accurate analysis of the sample. Biological material is applied to a substrate, such as a microscope slide. The biological specimen is then stained with a selected staining composition, which may be gentian violet for a Gram's Stain analysis. The stained biological material is at least partially decolorized and the level of decolorization is analyzed optically. If necessary, the decolorizing step and the optical analysis steps are repeated until a selected level of decolorization is obtained. | 03-26-2009 |
20090098646 | Staining and Sticking System - The staining and sticking system is composed of a staining device and a sticking device, which is provided separately from the staining device, is capable of lightening the staining and sticking work and can be downsized. The staining and sticking system comprises the staining device | 04-16-2009 |
20090162930 | ACTIVE GRIP FILTER PLUG FOR SAMPLE COLLECTION DEVICES - A system for collecting a biological sample includes a collection device comprising a cylindrical body having a bore extending there through and a filter membrane disposed at one end thereof; a filter plug having an insert configured for insertion into the bore; a collar concentrically mounted about the exterior surface of the insert and configured for insertion into the bore; and a gasket disposed about the exterior surface of the insert, wherein an outer dimension of the gasket is variable in response to relative movement between the collar and the insert, and wherein the gasket has a cross section with two end portions and a mid portion that is located radially further away from the insert than the two end portions. | 06-25-2009 |
20090239294 | Coaxial Tissue Block Puncher Set - A coaxial tissue block puncher set comprises a carrier mechanism, the first, second and third operating mechanisms being respectively installed at proper positions thereon, while each of the operating mechanisms respectively has a base and a lifting unit being movingly installed on the base, wherein lifting unit of the first operating mechanism is movingly installed with a first punch needle tube, lifting unit of the second operating mechanism being movingly installed with a second punch needle tube is pierced through the first punch needle tube, and lifting unit of the third operating mechanism being movingly installed with a thimble is pierced through the second punch needle tube. Therefore, user is able to punch-extract relevant pathological paraffin and put to relevant position in the empty block thereby forming a tissue array without the need for tedious manual methods thus achieving the effectiveness of fastness, precision and easy operation, etc. | 09-24-2009 |
20090253199 | Card Member for Receiving a Tissue Specimen to be Processed for Histological Examination - The present invention is directed to a card member for receiving a tissue specimen to be processed for histological examination including an absorbent portion for maintaining the tissue specimen in engageable contact with the card member, and a generally non-adhesive portion for allowing separation of the tissue specimen from the card member, where the card member provides the specimen with a known, consistent orientation throughout processing. | 10-08-2009 |
20100041131 | Blood specimen dispenser - A blood specimen dispenser is provided which dispenses a precise amount of collected blood from a blood specimen collector onto filter paper or the like for screening or evaluation. | 02-18-2010 |
20100055777 | TISSUE PROCESSOR - A tissue processor is described that comprises a retort for processing histological samples using various reagents, a plurality of exchangeable reagent supply containers that each comprise at least one container opening, a system of conduits, a control device for conveying reagents out of the reagent supply containers through at least one reagent conduit into the retort, and system bottles. The reagent supply containers and the system bottles are connected via the pertinent reagent conduits to at least one valve. The valve is electrically connected to the control device such that at least one of filling and emptying of the system bottles with reagents from the reagent supply containers is controlled. This design allows differently dimensioned reagent supply containers while at the same time minimizing the space requirement for the reagent containers. | 03-04-2010 |
20100099181 | Streaking Applicator Cartridge and a System for Connecting Same to a Streaking Apparatus - A cartridge for holding and dispensing streaking applicators for an automated streaking apparatus having a cartridge holder, the cartridge including: a case with a dispensing end, a longitudinal axis and an elongate slot generally parallel to the longitudinal axis, the dispensing end including an applicator dispensing position where one applicator can be at least partially accessible from outside the case; and an applicator support member constrained within the case for longitudinal movement therein and being able to carry a stack of applicators; the elongate slot being capable of operatively receiving a biasing member when the cartridge is in the cartridge holder to urge the support member towards the dispensing end and an applicator into the dispensing position. | 04-22-2010 |
20100178695 | SPECIMEN PREPARATION APPARATUS, SPECIMEN PREPARATION/ANALYSIS SYSTEM AND SPECIMEN PLATE - Provided is a specimen preparation apparatus capable of supplying a specimen from the specimen preparation apparatus to a specimen analyzer without burdening an operator. This specimen preparation apparatus comprises a stained specimen preparation part for preparing a specimen on a slide glass and staining the specimen, a keeping part for storing the stained specimen slide glass prepared in the stained specimen preparation part and a control part for deciding whether to supply the stained specimen slide glass to the keeping part or to the external apparatus. | 07-15-2010 |
20100304475 | DEVICE FOR COLLECTING SAMPLE - Disclosed herein is a device for collecting a sample, which is intended to dispense a received sample onto a measurement strip. The device includes a main body and a pair of receiving pieces. The receiving pieces protrude from a first end of the main body in such a way as to be spaced apart from each other while facing each other, and receive the sample by capillary force acting on a space which is defined between the receiving pieces and which is open on right, left and bottom sides. The device allows the received sample to be easily transferred to a reaction zone of a measurement strip, and enables the sample to be completely absorbed by the reaction zone because of capillary force in a receiving area when the device comes into contact with the reaction zone of the strip. | 12-02-2010 |
20100330665 | METHOD FOR PRODUCING A CELL CULTURE SUBSTRATE - A main object of the invention is to provide a new method for producing a cell culture substrate used to cause cells to adhere in a highly precise form onto a base material and then culture the cells. | 12-30-2010 |
20110081716 | AUTOMATED SEED SAMPLER AND METHODS OF SAMPLING, TESTING AND BULKING SEEDS - A seed sampler system generally includes an automated sampling station configured to orient a seed and remove a tissue sample from the oriented seed. The seed sampler system may include a support configured to orient a seed received by the support, and an automated sampling mechanism configured to remove a tissue sample from the oriented seed. | 04-07-2011 |
20110086420 | POLYMER SUBSTRATE WITH FLUORESCENT STRUCTURE, METHOD FOR THE PRODUCTION THEREOF AND THE USE THEREOF - The invention relates to polymer substrates which are provided with fluorescence features and in which photochemical fluorescence features, i.e. fluorescent structures, are produced by UV irradiation. Thus, fluorophores can be produced in polymer substrates with a low inherent fluorescence by means of suitable UV radiation, which fluorophores display a marked and detectable emission upon being excited with light of a suitable wavelength. If such an irradiation is implemented in a structured manner, emission patterns can be produced in this way in polymer substrates, which emission patterns can be applied for example as recovery grids in fluorescence microscopy. A further application field relates to product authentication which is made possible by the polymer substrates according to the invention provided with fluorescence features. | 04-14-2011 |
20110269224 | Tissue Container for Molecular and Histology Diagnostics Incorporating a Breakable Membrane - A container for storing a biological sample for molecular diagnostic testing and/or histological testing is provided. The container includes a first chamber for receiving a sample holder therein, a second chamber, and a closure for enclosing the container. A breakable membrane, such as a piercable foil, extends within the container and separates the two chambers. When the breakable membrane is broken, fluid can pass between the first and second chambers. The membrane may be broken through an activator on the closure, such as a depressible member or a rotatable carrier, causing the sample holder to break through the membrane. | 11-03-2011 |
20110312085 | IN SITU HEAT INDUCED ANTIGEN RECOVERY AND STAINING APPARATUS AND METHOD - An automated in situ heat induced antigen recovery and staining method and apparatus for treating a plurality of microscope slides. The process of heat induced antigen recovery and the process of staining the biological sample on the microscope slide are conducted in the same apparatus, wherein the microscope slides do not need to be physically removed from one apparatus to another. Each treatment step occurs within the same reaction compartment. The reaction conditions of each reaction compartment for treating a slide can preferably be controlled independently, including the individualized application of reagents to each slide and the individualized treatment of each slide. The reagents are preferably held in a reagent dispensing strip similar to a “blister pack”. | 12-22-2011 |
20120107922 | TAMPERING DEVICE USED DURING EMBEDDING OF BIOLOGICAL TISSUE SAMPLES - A tampering device may comprise a tamper, an elongated handle, and an insulator rod. The elongated handle may have a first end and a second end. The insulator rod may be adapted to connect to the tamper and the first end of the elongated handle. The elongated handle may have a gripping ridge and a plurality of valleys. The valleys may include a plurality of dimples to increase the surface of interface between the user's fingers and the handle. | 05-03-2012 |
20120122202 | FLASK FOR PREPARING A CYTOLOGICAL SUSPENSION BASED ON A FIXING SOLUTION - A system for preparing a cytological suspension is based on a fixing solution. The system containing a cytological sample-taking brush and a flask having an opening for receiving the cytological sample-taking brush are detachably fastened to a handle including a brush-receiving filter basket that is at least partially immersed in the a suspension. | 05-17-2012 |
20120214227 | APPARATUS FOR PREPARING CYTOLOGICAL SPECIMENS - A handheld apparatus for preparing a specimen slide includes a handle, a filter holder assembly coupled to and extending from the handle; and a slide holder assembly coupled to and extending from the handle spaced apart from the filter holder assembly, wherein the slide holder assembly comprises a plurality of positioning members movably coupled to one another, and a slide holder movably coupled to one of the positioning members to allow a slide mounted on the slide holder to make rolling contact with an outward facing surface of a filter mounted on the filter holder assembly. | 08-23-2012 |
20120288929 | INOCULATING APPARATUS FOR BIOLOGICAL SAMPLES IN AGAR SURFACE OF PETRI CAPSULES - A disposable microsyringe, whose tubular body is attached by its rear end into the front starting point of a longitudinal void of an intermediate housing, has located in the longitudinal void a moving head movable upon an axis and, which is connected to the rear end of the syringe plunger. The moving head is also connected, by a longitudinal rod, to a moving carriage movable upon an axis along the same direction as the moving head, and being said moving carriage guided within an elongated tube connected to at the rear end of the intermediate housing, as a continuation thereof, incorporating to said elongated tube a motor element, whose actuation drives the plunger via a moving head, a longitudinal rod and a moving carriage. | 11-15-2012 |
20120322144 | MICROFLUIDIC DEVICES AND SYSTEMS - A device may be configured to allow manipulation of the cell(s), such as test or drug applications, independent of the operation and/or structure of the device. The device may be configured to separate, hold and release at least one cell suspended in a fluid. The device may include a region configured to receive the fluid including at least one cell; a cell holding device that is in open communication with the region and includes at least one cell isolation region configured to releasably separate and hold each cell; and a passage that is configured to receive and supply pressure to the cell holding device. The device may further include a second region that includes the cell holding device and is in fluid communication with the region. | 12-20-2012 |
20120329148 | BLOOD CORPUSCLE SEPARATION CHIP - A corpuscle separation chip is presented, which is capable of separating plasma from blood using capillary forces without causing leakage of the blood in undesired directions. The corpuscle separation chip may include an upper board for securing a membrane such that one or more edges maintain non-contact, where a portion of a channel is formed in the upper board to provide a path causing plasma components separated by the membrane from blood to move in one direction; and a lower board in which another portion of the channel is formed, where the lower board is configured to join with the upper board to form the channel, and the lower board is configured to cause the plasma components to move along the channel due to capillary forces at a position corresponding to one side of a lower surface of the membrane. By using such corpuscle separation chip, each of the edges of the membrane can maintain as much non-contact as possible with the structure formed by an upper board and a lower board attached to each other, to prevent leakage of the loaded blood in undesired directions. | 12-27-2012 |
20130196426 | BASE BODY AND METHOD OF MANUFACTURING BASE BODY - Disclosed is a substrate ( | 08-01-2013 |
20130244321 | Automated Seed Sampler and Methods of Sampling, Testing and Bulking Seeds - An automated system for sampling seeds generally includes an automated sampling station having a seed feeder and a seed sampler. The seed feeder is configured to deliver seeds to the seed sampler, and the seed sampler is configured to remove material from the seeds without substantially adversely affecting the germination viability of the sampled seeds. The system also includes a sample handling station configured to receive the material removed from the seeds, and a seed handling station configured to receive the sampled seeds after the material is removed from the seeds such that the relationship between the material removed from the seeds and the respective seeds can be determined. | 09-19-2013 |
20130288360 | CELL COLLECTING DEVICE - A cell collecting device is configured to collect target cells from a fluid sample such as blood or physiological fluid. The cell collecting device includes a first filter having a plurality of first pores formed into a size that enables target cells contained in a fluid sample to pass through the first pores, and a second filter having a plurality of second pores formed into a size that enables the target cells contained to pass through the second pores. The second filter is arranged below the first filter in such a position as to filter the target cells. | 10-31-2013 |
20130295664 | MICROBIAL AIR SAMPLER - An air sampler device has a top plate and a bottom plate, and receives a Petri dish between the top plate and the bottom plate. The top plate includes 283 substantially small holes. The bottom plate has a deepened center well formed in the top surface. Elongated slots are formed in the top surface which extend out from the well. The slots have distal ends which extend beyond the Petri dish. Air is drawn into the sampler by a vacuum tube through an air port which communicates with the center well. Air is pulled into the 283 holes in the top plate and strikes the capture material in the Petri dish. The air then travels up over the sides of the dish, into the distal ends, through the slots, and into the center well, where it exits out of the vacuum air port. | 11-07-2013 |
20130309763 | SAMPLE FEEDING APPARATUS, FLOW CYTOMETER, AND SAMPLE FEEDING METHOD - A sample feeding apparatus includes a first cylinder, a second cylinder, and a sealing section. The first cylinder is configured to be mounted with a sample tube. The second cylinder is configured to move the first cylinder between a first position and a second position, the first position being for mounting of the sample tube, the second position being for feeding of a sample in the sample tube. The sealing section is configured to cover the sample tube, the sample tube being mounted to the first cylinder being at the second position, the first cylinder applying pressure to an inner space of the sealing section at the second position. | 11-21-2013 |
20130309764 | APPARATUS FOR REMOVAL OF SPECIFIC SEED TISSUE OR STRUCTURE FOR SEED ANALYSIS - An apparatus for reducing resources for selecting seed to be produced in commercial quantities or for research is disclosed. Samples of seed which are candidates for selection are collected and given an identifier. Specific tissue or structure from candidate seed is removed. A test or analysis is performed on the candidate seed or the removed tissue or structure. Results of the test or analysis are recorded and correlated to the seed's identifier. The results are evaluated and a decision is made whether to select a candidate seed for commercial production or for research. Time, space, and labor associated with growing plants in an experimental plot or greenhouse and taking tissue samples from growing plants is saved. | 11-21-2013 |
20130337555 | Cassette For Sample Preparation - Apparatuses for preparing a sample are disclosed herein. The apparatuses include a chamber, a first valve at least partially disposed in the first chamber, a second valve at least partially disposed in the first chamber, and a pump comprising an actuator and nozzle. | 12-19-2013 |
20130344588 | DEVICES AND METHODS FOR CONCENTRATION AND ANALYSIS OF FLUIDS - Disclosed are articles, compositions and methods for detecting analytes. The disclosed articled, compositions and methods increase the ease of detection and quantitation of the target analyte. | 12-26-2013 |
20130344589 | DEVICE FOR SEPARATING ADULT STEM CELL - The invention relates to a device ( | 12-26-2013 |
20140017779 | Membrane Transfer Method And Tool - A method for transferring a filter membrane ( | 01-16-2014 |
20140030803 | DEVICE AND METHOD FOR CONCENTRATING AND DETECTING PATHOGENIC MICROBES FROM BLOOD PRODUCTS AND/OR THEIR DERIVATIVES - The invention concerns a device and a method for concentrating pathogenic germs potentially present in blood products or derivatives and for detecting said germs comprising the following steps: (a) subjecting a sample of said blood product to a blood cell aggregating treatment, (b) eliminating the aggregates formed at step (a) by passing the treated sample over a first filter allowing through the contaminating germs but not the cell aggregates, (c) selectively lyzing the residual cells of the filtrate obtained at step (b), (d) recuperating the contaminating germs by passing the lysate of step (c) over a second filter to detect the contaminating germs possibly trapped. | 01-30-2014 |
20140057347 | METHOD AND APPARATUS FOR PREPARING CYTOLOGICAL SPECIMENS - An automated system for preparing a plurality of cytological specimens from a plurality of fluid samples in vials includes an apparatus for collecting a monolayer of cells from each sample and transferring the cells to a microscope slide for fixing, staining, and inspection. The system includes a first loading station for receiving the sample vials, a second loading station for receiving consumables such as filter membranes, a slide dispenser, and an unloading area for removing completed specimen slides. To maintain one-to-one correlation between the samples and specimens produced therefrom, the system includes a subsystem for identifying each sample and permanently marking each slide with corresponding indicia prior to transferring the specimen thereto. | 02-27-2014 |
20140087456 | Isolating Target Cells From A Biological Fluid - A micro-fluidic device operable to isolate target cells from a biological fluid comprises: an inlet operable to receive the biological fluid, the biological fluid comprising target cells and other components; a waste outlet operable to receive at least the other components of the biological fluid; a plurality of parallel arrays of cell isolation wells coupling the inlet with the waste outlet, each parallel array of cell isolation wells supporting a flow of the biological fluid from the inlet to the waste outlet in response to a pressure differential thereacross, each array of cell isolation wells comprising a plurality isolation wells, each isolation well being dimensioned to mechanically trap the target cells therein whilst permitting flow of other components of the biological fluid; and at least one pressure maintenance structure operable to assist in maintaining a predetermined pressure differential across each of the plurality of parallel arrays of cell isolation wells. | 03-27-2014 |
20140106445 | METHOD FOR QUANTITATIVE TRANSFER OF ANALYTES - A method for transferring a quantity of analytes comprising at least stages of: predisposing a substantially homogeneous mixture of a predetermined initial quantity of at least an analyte and a liquid, obtaining a known concentration value or known amount of the analyte in the mixture; introducing into the mixture at least a collecting portion ( | 04-17-2014 |
20140113366 | MICROFLUIDIC SYSTEM FOR CONTROLLING THE CONCENTRATION OF MOLECULES FOR STIMULATING A TARGET - The invention relates to a microfluidic system for controlling a card for the concentration of molecules capable of stimulating a target, for example formed by an assembly of living cells, characterized in that the system comprises a microfluidic device ( | 04-24-2014 |
20140134717 | FLUID TREATMENT APPARATUS AND METHOD - A fluid treatment apparatus and method. The fluid treatment apparatus includes a chamber containing a first fluid with a first density and a second fluid with a second density, a channel disposed in the chamber to discharge the first fluid from the chamber, and a valve material disposed in the channel, wherein the valve material controls the discharge of the first fluid from the chamber based upon a phase transition characteristic. | 05-15-2014 |
20140134718 | FILTER MODULE IN BIOMOLECULE ISOLATION - The present invention relates to a device for rapid isolation of target molecules from cell lysates and other liquid mixtures comprising particulate material, a method for isolating the target molecules, in particular nucleic acids, using said device and a kit for carrying out said method comprising said device. | 05-15-2014 |
20140162353 | FLUID SEGMENT SAMPLING DEVICE - A fluid segment sampling device and method wherein a housing includes an input port configured to receive a segment tube, an output port configured for a receptacle, a passageway between the input port and the output port, and a side port leading into the passageway. A blade unit is insertable in the side port to cut a segment tube inserted into the input port. | 06-12-2014 |
20140162354 | METHOD AND SYSTEM FOR USE OF TREATMENT LIQUIDS IN AN APPARATUS FOR STAINING OF TISSUE SPECIMENS ON MICROSCOPE SLIDES - A method and a system for use of treatment liquids in an apparatus for staining of tissue specimens on microscope slides, wherein the apparatus comprises a plurality of vessels ( | 06-12-2014 |
20140212963 | Device For Isolating A Fraction In A Biological Sample - A device and a method are provided for isolating a fraction in a biological sample. The fraction is bound to solid phase substrate to define a fraction-bound solid phase substrate. The device includes an input zone for receiving the biological sample therein and a second zone for receiving an isolation fluid therein. A force is provided that is generally perpendicular to gravity. The force is movable between a first position adjacent the input zone and a second position adjacent the isolation zone. The force captures the fraction-bound solid phase substrate and the fraction-bound solid phase substrate moves from the input zone to the isolation zone in response to the force moving from the first position to the second position. | 07-31-2014 |
20140220673 | METHODS AND APPARATUS FOR THE ISOLATION AND ENRICHMENT OF CIRCULATING TUMOR CELLS - Embodiments in accordance with the present invention relate to methods and apparatuses for concentrating and isolating Circulating Tumor Cells (CTCs) from body fluids. One embodiment of the present invention includes a micro-fabricated or nano-fabricated device having channels configured for separating and excluding. Embodiments in accordance with the present invention utilize features that reduce the hydrodynamic pressure experienced by the cells during the separation, isolation and concentration processes, and therefore reduce the likelihood of cell lysis or other damage to the cells. | 08-07-2014 |
20140329308 | PLATFORM FOR IMMOBILIZATION AND OBSERVATION OF SUBCELLULAR PROCESSES - A method of immobilizing matter for imaging that includes providing an array of nanofibers and directing matter to the array of the nanofibers. The matter is immobilized when contacting at least three nanofibers of the array of nanofibers simultaneously. Adjacent nanofibers in the array of nanofibers may be separated by a pitch as great as 100 microns. The immobilized matter on the array of nanofibers may then be imaged. In some examples, the matter may be cell matter, such as protoplasts. | 11-06-2014 |
20140335604 | DEVICE FOR STAINING SUSPENDED CELLS - A device for staining suspended cells composed of a cannula ( | 11-13-2014 |
20140342449 | METHOD AND DEVICE FOR PRODUCING AND/OR PURIFYING POLYNUCLEOTIDES AND PRODUCTS OBTAINABLE THEREOF - An apparatus and a method for obtaining a (poly)nucleotide sequence of interest include steps of cultivating hosts cells to produce a nucleotide sequence of interest and harvesting these cells, introducing these cells in a passageway and disintegrating them in a continuous process. In the continuous process, performing in the passageway a precipitation of contaminants by a mixing of the disintegrated cells with a solution containing one or more salt(s) and obtaining a mixture and allowing a precipitate to separate from the solution of this mixture, preferably to float and/or to sediment from the solution of this mixture for 1-48 hours and pumping out a soluble material from this solution, while excluding recovering the precipitate. | 11-20-2014 |
20140349387 | Sampling Device - The present invention generally relates to devices, systems, and methods for acquiring and/or dispensing a sample without introducing a gas into a microfluidic system, such as a liquid bridge system. An exemplary embodiment provides a sampling device including an outer sheath; a plurality of tubes within the sheath, in which at least one of the tubes acquires a sample, and at least one of the tubes expels a fluid that is immiscible with the sample, in which the at least one tube that acquires the sample is extendable beyond a distal end of the sheath and retractable to within the sheath; and a valve connected to a distal portion of the sheath, in which the valve opens when the tube extends beyond the distal end and closes when the tube retracts to within the sheath. | 11-27-2014 |
20140349388 | System And Process For Separating A Material - Disclosed is a system to separate, enrich, and/or purify a cellular population from a biological tissue, such as a tissue sample. For example, an adipose tissue sample can be acquired and disrupted. The disrupted tissue sample can then be separated and purified. The separated components can include multipotent, pluripotent, or other cell populations. | 11-27-2014 |
20140356942 | ISOLATOR - An isolator includes: a chamber including a working chamber in which a work is performed by a worker, and a storage chamber provided under the working chamber in communication with an opening formed in a bottom plate of the working chamber, the chamber being configured to isolate the working chamber and the storage chamber from an exterior while in a state where airtightness is maintained; and a lifting device configured to support, in the storage chamber, an experimental device to be used in the working chamber, the lifting device being capable of lifting and lowering the experimental device from the storage chamber to the working chamber and from the working chamber to the storage chamber. | 12-04-2014 |
20140370589 | SUBJECT SELECTION DEVICE AND SUBJECT SELECTION METHOD - A suction tip includes a tip opening, a tubular passage provided with a first selector configured to permit the passage of non-selection subjects included in a collection of subjects sucked through the tip opening, and a capture portion provided on a side of the tubular passage downstream of the first selector in a suction direction of the collection of subjects and configured to capture the non-selection subjects. The capture portion includes a passage hole configured to permit the passage of the non-selection subjects and a storage portion configured to store the non-selection subjects having passed through. | 12-18-2014 |
20150050726 | INSTRUMENT FOR CASSETTE FOR SAMPLE PREPARATION - A parallel processing system for processing samples is described. In one embodiment, the parallel processing system includes an instrument interface parallel controller to control a tray motor driving system, a close-loop heater control and detection system, a magnetic particle transfer system, a reagent release system, a reagent pre-mix pumping system and a wash buffer pumping system. | 02-19-2015 |
20150056695 | APPARATUS FOR SPREADING A FLUID ACROSS A SUBSTRATE AND METHOD OF USING THE SAME - This disclosure is directed to an apparatus and method for spreading a fluid across a substrate. A spreader for spreading a fluid across a substrate includes a wiper and a frame. The wiper and the frame may mate to permit translation of the wiper across, and with respect to, the frame. The wiper spreads the fluid across the substrate and the frame supports the wiper and the substrate. The frame may also include a ramp to cause a portion of the wiper to lift away from the substrate. | 02-26-2015 |
20150072411 | MULTIPLE SLIDE PROCESSING APPARATUS - A slide processing apparatus comprises a slide or processing station which may include a plurality of cuvettes, each cuvette configured to receive a slide. A reagent fluid supply is coupled to each cuvette to deliver and apply reagent for treatment of the slide. A slide gripper is disposed above the slide processing station and is configured to move the slide in and out of the cuvettes. A screw assembly is disposed adjacent the slide processing station, the screw assembly configured to receive a plurality of slides, wherein rotation of the screw assembly advances the plurality of slides for engagement by the slide gripper. | 03-12-2015 |
20150079671 | Device for performing biopsies on a vesicular object - A device for removing material from a vesicular object, said device being a pipette having a sealed tip at its distal end and an aperture whereby the distal tip of the device is inserted into the target object, the aperture aligned with the material to be removed from the object, vacuum applied to the inside of the device, such vacuum drawing the material into the aperture, and the device being removed from the object in such a manner as to cut or otherwise separate the material in the pipette from the object, the material remaining in the pipette, while leaving the object undamaged. | 03-19-2015 |
20150079672 | SYSTEMS AND METHODS FOR PROCESSING CELLS - The present invention efficiently and cost-effectively extracts and collects cells from a tissue. The inventors have discovered that the tissue can be effectively fragmented and the resulting cells can be purified using a system or kit with multiple components. An advantage of the present invention is that tissue processing takes place in a closed system such that sterility can be maintained throughout the process, even if certain components are removed during processing, for example through the use of valves, clamps, and heat seals. Furthermore, any or all of the steps can be automated or manually accomplished, according to the specific needs of the application or the user. | 03-19-2015 |
20150111293 | CANCER CELL-TRAPPING METAL FILTER, CANCER CELL-TRAPPING METAL FILTER SHEET, CANCER CELL-TRAPPING DEVICE, AND MANUFACTURING METHODS THEREFOR - Provided are a cancer cell-trapping metal filter which has a high opening ratio, a cancer cell-trapping metal filter sheet, a cancer cell-trapping device using the cancer cell-trapping filter, and manufacturing methods therefor. | 04-23-2015 |
20150292991 | Disposable Direct Capture Device - The invention relates to a liquid sample preparation device such as a disposable, collapsible, flexible polymeric bag containing an adsorptive curtain of a functionalized shaped polymeric fiber bed for the direct capture of biomolecules from liquid samples. The functionalized shaped polymeric fiber bed includes fibrillated, ridged or winged-shaped fiber structures that significantly increases the surface area of the fiber resulting in enhanced separation, retention and/or purification of liquid samples containing biomolecules of interest as the liquid samples contact the adsorptive curtain of functionalized shaped fibers. Liquid samples include unclarified liquid feeds or other liquids containing one or more biomolecules of interest, including, but not limited to vaccines, recombinant proteins, cells, stem cells, monoclonal antibodies (mAbs), proteins, antibody, peptides, oligopeptides, nucleic acids, oligonucleotides, RNA, DNA, oligosaccharides and polysaccharides. | 10-15-2015 |
20150298121 | SUBSTANCE EXPOSURE APPARATUS - An apparatus including an array of wells including a number of well channels, each well channel including a plurality of wells in the well channel, the wells containing a substance in use, one or more inlets for receiving respective fluids and channels coupled to the one or more inlets for selectively supplying one or more fluids to each well channel to thereby expose the substance to different conditions allowing a response of the substance to the conditions to be determined. | 10-22-2015 |
20150298122 | SYSTEM AND METHOD FOR MICROFLUIDIC FLOW CONTROL - A system and method for controlling fluid flow within a microchannel includes a fluid circuit comprising a fluid outlet well and one or more fluid inlet wells, all in communication with a microchannel. A negative pressure differential is applied to the outlet well and fluid flow from an inlet well into the microchannel is controlled by opening or closing the inlet well to atmospheric pressure. To stop fluid flow from the inlet well, a negative pressure differential may be applied to the inlet well to equalize pressure between the inlet and outlet wells. By sequentially opening and closing different inlet wells to atmosphere, controlled amounts of different reagents can be serially introduced into the microchannel. | 10-22-2015 |
20150299766 | AUTOMATION OF BARRIER-BASED PLANT NUCLEIC ACID AND PROTEIN EXTRACTION - This invention is related to systems and methods for nucleic acid/protein extraction/isolation from biological samples. In particular, automated barrier-based systems for samples from plant tissues/cells are disclosed. The automated systems and methods disclosed provide reliability and high throughput specifically suitable for nucleic acid/protein extraction/isolation from plant tissues/cells. In some embodiments, the automated systems disclosed can further enhance high throughput capacity for nucleic acid/protein extraction/isolation directly from plant tissue samples. | 10-22-2015 |
20150314289 | VALVING SYSTEM FOR USE IN CENTRIFUGAL MICROFLUIDIC PLATFORMS - The invention relates to a microfluidic system for processing biological samples comprising a holding chamber adapted for holding a fluid and to be rotated on a platform, said holding chamber comprising an outlet through which fluid flow is controlled by an acceleration-primed valve system, wherein the acceleration—primed valve system comprises a capillary valve and an outlet channel. The invention provides a novel valving system, which retains fluids at low angular velocities, removes the need for hydrophilic surfaces, minimises disc real-estate and optimises certain microfluidic processes done in the holding chamber. | 11-05-2015 |
20150315537 | CELL DETACHMENT DEVICE - A cell detachment device includes: a base; a vessel holder, to which a culture vessel is to be fitted; a guide mechanism configured to guide reciprocating movement of the vessel holder; a collided member configured to collide with the vessel holder when the vessel holder is moving; an urging member configured to urge the culture vessel toward the collided member; and a power imparting mechanism configured to impart, to the vessel holder, power for causing the vessel holder to move. | 11-05-2015 |
20150316454 | CARTRIDGE AND APPARATUS FOR PREPARING A BIOLOGICAL SAMPLE - The invention relates to a cartridge ( | 11-05-2015 |
20150323428 | APPARATUS FOR SPREADING A FLUID ACROSS A SUBSTRATE AND METHOD OF USING THE SAME - This disclosure is directed to an apparatus and method for spreading a fluid across a substrate. A spreader for spreading a fluid across a substrate includes a wiper and a frame. The wiper and the frame may mate to permit translation of the wiper across, and with respect to, the frame. The wiper spreads the fluid across the substrate and the frame supports the wiper and the substrate. The frame may also include a ramp to cause a portion of the wiper to lift away from the substrate. | 11-12-2015 |
20150328632 | SENSOR ELEMENT, METHOD FOR MANUFACTURING SENSOR ELEMENT, AND SENSOR CARTRIDGE - A sensor element comprising a tape-shaped mount film; and a plurality of film-shaped sensors bonded on one surface of the mount film, wherein the front and rear film-shaped sensors are spaced at a predetermined distance in a lengthwise direction of the mount film, and a crosswise length of each film-shaped sensor is shorter by a predetermined quantity than a crosswise length of the mount film. | 11-19-2015 |
20150330965 | MICROBIAL AIR SAMPLER - An air sampler device has a top plate and a bottom plate, and receives a Petri dish between the top plate and the bottom plate. The top plate includes 283 substantially small holes. The bottom plate has a deepened center well formed in the top surface. Elongated slots are formed in the top surface which extend out from the well. The slots have distal ends which extend beyond the Petri dish. Air is drawn into the sampler by a vacuum tube through an air port which communicates with the center well. Air is pulled into the 283 holes in the top plate and strikes the capture material in the Petri dish. The air then travels up over the sides of the dish, into the distal ends, through the slots, and into the center well, where it exits out of the vacuum air port. | 11-19-2015 |
20150336096 | Sorting Particles Using High Gradient Magnetic Fields - This disclosure describes microfluidic devices that include one or more magnets, each magnet being operable to emit a magnetic field; and a magnetizable layer adjacent to the one or more magnets, in which the magnetizable layer is configured to induce a gradient in the magnetic field of at least one of the magnets. For example, the gradient can be at least 10 | 11-26-2015 |
20150343437 | DUCT DEVICE - A flow channel device includes the following elements: an introduction region for receiving a specimen into the flow channel; a discharge region for discharging the specimen; and a trap body between the introduction region and the discharge region. In the trap body formed in the flow channel, the lateral area of the lateral side surface of the trap body facing the introduction region side is larger than the projected area of the lateral side surface of the trap body projected along the flow channel from the introduction region side toward the discharge region side with respect to the trap body. | 12-03-2015 |
20150343444 | Hydrodynamic Trap Array - Hydrodynamic Trap Array. the array includes a serpentine bypassing channel including a plurality of trapping pockets disposed therein, the trapping pockets including a ramp entry portion to decrease flow velocity orthogonal to the trapping pocket to increase trapping efficiency. The relative fluid resistances of the trapping pockets and the serpentine bypassing channel are selected such that a slight majority of the flow is diverted to one of the trapping pockets. A pair of microfluidic bypass channels flank the array of traps allowing independent control of upstream and downstream pressures on each side of the array, thereby decoupling flow magnitude in the bypass channels from flow across the trapping pockets. | 12-03-2015 |
20150360220 | CELL CULTURE SCRAPING DEVICE - A device for scraping cells and tissues and methods of fabricating the same are disclosed herein. | 12-17-2015 |
20150360222 | Sampling Device for Fluids - Device for sampling ( | 12-17-2015 |
20150377747 | A SAMPLE HANDLING DEVICE - Sample handling device which enables to take samples (samples of living beings) from single celled invertebrate living beings which live in different depths of aqueous mediums such as lakes, ponds, barrages and sea shore zones. The aim is to take samples from vertebrate living beings which live by attaching themselves on living beings or non living materials such as plants, stones and shells in aqueous medium such as lakes, ponds, barrages and shore zones. Another aim is to present the medium where single cell living beings live and to carry such living beings to the laboratory in order to examine them. | 12-31-2015 |
20160011084 | Preparing Blood Smears on a Fiber Surface | 01-14-2016 |
20160018302 | Automated Systems and Methods for Preparing Biological Specimens For Examination - The apparatus disclosed herein features a substrate arm and gripper, a platform having a top surface located opposite the substrate when the substrate arm is in a specimen processing position and featuring at least one fluid port located on a surface of the platform facing the substrate and at least one vacuum port located on the surface of the platform facing the substrate, and during operation, the apparatus is configured to (a) dispense a first quantity of fluid from the at least one fluid port to fill a separation between the substrate and the platform, (b) dispense an additional quantity of fluid from the at least one fluid port into the separation to displace a portion of the first quantity of fluid, and (c) remove the portion of the first quantity of fluid from the separation through the at least one vacuum port. | 01-21-2016 |
20160018392 | TRENCHED SAMPLE ASSEMBLY FOR DETECTION OF ANALYTES WITH ELECTROMAGNETIC READ-WRITE HEADS - A sample assembly includes an outer layer with at least one sample trench. The sample trench includes a first set of antibodies that are bonded on a first surface of a base layer. Target antigens are bonded with the first set of antibodies, and a second set of antibodies are bonded to the target antigens. Further, the sample trench includes nanoparticles that are bonded to the second set of antibodies. | 01-21-2016 |
20160051445 | DEVICE FOR THE COLLECTION, REFINEMENT, AND ADMINISTRATION OF GASTROINTESTINAL MICROFLORA - Devices and systems for isolating gastrointestinal microflora from stool collected from a donor are provided. Stool is collected from a donor in a container as the donor is defecating. A solvent is introduced into the container and the container sealed to place its contents in a sealed environment. Various agents can be added to achieve dissolving, colorizing, deodorizing, or for further therapies. The solvent and collected stool is homogenized into a mixture which is then filtered by a multi-stage filter system to create a solution containing microflora in the desired consistency. This solution can be dispensed via an enema tube or other delivery apparatus for infusion into a patient's gastrointestinal tract. | 02-25-2016 |
20160059234 | COLLECTOR ARCHITECTURE LAYOUT DESIGN - The disclosure provides for compositions and methods for the collection of rare cells using an interspersed microstructure design. | 03-03-2016 |
20160068385 | MICROFLUIDIC DEVICES AND METHODS FOR THE EXTRUSION OF TUBULAR STRUCTURES - Methods and devices are disclosed for the controlled formation of structures, including tubular structures, using microfluidic devices. In one embodiment, a microfluidic device includes three or more microfluidic arrays that are provided in a stacking configuration, with an inner streaming layer and an outer streaming layer for flowing a streaming fluid, and at least one intermediate matrix layer for flowing a matrix fluid. Fluid flow in each layer is directed from a peripheral region towards, and distributed around, a common central outlet. Guided by the streaming fluid, a sheath of matrix solution is formed, which may be solidified to form a tubular material. Some embodiments allow for the controlled and continuous extrusion of tubular structures with tailored heterogeneities and/or predictable mechanical and chemical properties. Devices and methods are also provided for the on- and off-chip fixation and optional perfusion of tubular structures. | 03-10-2016 |
20160075986 | DEVICE FOR AUTOMATED SEEDING OF CULTURE MEDIUM - The invention relates to a device ( | 03-17-2016 |
20160089669 | Apparatus for Multiplex Extraction of Biological Samples and In-Transit Preparation of the Same - The invention relates to a device for the rapid simultaneous collection, and, optionally, treatment or standardization, of multiple aliquots of a liquid biological sample such as blood from a single source drop or sample portion, the device comprising device comprising a cover, a spreading layer comprising a macroporous membrane adjacent to the cover, where the spreading layer comprises a transport portion and at least one accumulation portion in fluid connection with the transport portion, and at least one collection portion in fluid connection with each accumulation portion. | 03-31-2016 |
20160096172 | METHOD AND APPARATUS FOR THE DISCRETIZATION AND MANIPULATION OF SAMPLE VOLUMES - Embodiments of the present invention relate to methods and apparatuses for the discretization and manipulation of sample volumes that is simple, robust, and versatile. It is a fluidic device that partitions a sample by exploiting the interplay between fluidic forces, interfacial tension, channel geometry, and the final stability of the formed droplet and/or discretized volume. These compartmentalized volumes allow for isolation of samples and partitioning into a localized array that can subsequently be manipulated and analyzed. The isolation of the discretized volumes along with the device's inherent portability render our invention versatile for use in many areas, including but not limited to PCR, digital PCR, biological assays for diagnostics and prognostics, cancer diagnosis and prognosis, high throughput screening, single molecule and single cell reactions or assays, the study crystallization and other statistical processes, protein crystallization, drug screening, environmental testing, and the coupling to a wide range of analytical detection techniques for biomedical assays and measurements. The minimal fluid interconnects and simple flow geometry makes the device easy to use and implement, economical to fabricate and operate, and robust in its operations. | 04-07-2016 |
20160107161 | UNITIZED REAGENT STRIP - The embodiments disclosed herein relate to unitized reagent strips for holding and transporting reagents and materials used in automated sample preparation and/or processing for biological and or chemical assays. | 04-21-2016 |
20160130557 | Formulations Containing and Kit for Using Adipose-Derived Stem Cells and Use Thereof - Methods and kits for producing cellular fractions enriched in adipose derived stem cells. Methods are provided where adipose tissue obtained from liposuction is enzymatically treated using a solution containing collagenase and divalent cations prior to the application of traditional methods of stromal-vascular fraction isolation. The enzymatic solutions may contain collagenase types I and II to a final concentration of about 0.001 mg/ml to 0.010 mg/ml. The divalent cations may be present as calcium, magnesium, and zinc chloride. The final concentration of calcium, magnesium, and zinc may range from about 0.001 to 0.1 micromolar; about 0.005 to 0.5 micromolar; and about 0.0015 to 0.15 micromolar, respectively. The enzymatic solutions may be generated using a kit where the collagenase and divalent components are held in separate containers until just prior to use. The cellular fractions isolated in this manner may be used in autologous fat grafts in therapeutic applications. | 05-12-2016 |
20160136646 | Interconnect Adaptor - An interconnect adaptor for connecting a microfluidic device to a fluidic system. The interconnect adapter includes a base substrate and a nozzle array. The base substrate includes a first side and a second side. The nozzle array includes two or more nozzles extending away from the base substrate. Each nozzle includes an opening with a channel extending therefrom. The channels are configured to transport fluid between the microfluidic device and the fluidic system. Each of the nozzles is configured to be inserted into a respective hole in the microfluidic device, in some embodiments, the insertion forms a radially sealed connection between each nozzle and respective hole when the nozzles are inserted a predetermined distance into the respective holes. | 05-19-2016 |
20160138010 | INSTRUMENT FOR CASSETTE FOR SAMPLE PREPARATION - A parallel processing system for processing samples is described. In one embodiment, the parallel processing system includes an instrument interface parallel controller to control a tray motor driving system, a close-loop heater control and detection system, a magnetic particle transfer system, a reagent release system, a reagent pre-mix pumping system and a wash buffer pumping system. | 05-19-2016 |
20160144378 | Devices And Method For Enrichment And Alteration Of Cells And Other Particles - The invention features devices and methods for the deterministic separation of particles. Exemplary methods include the enrichment of a sample in a desired particle or the alteration of a desired particle in the device. The devices and methods are advantageously employed to enrich for rare cells, e.g., fetal cells, present in a sample, e.g., maternal blood and rare cell components, e.g., fetal cell nuclei. The invention further provides a method for preferentially lysing cells of interest in a sample, e.g., to extract clinical information from a cellular component, e.g., a nucleus, of the cells of interest. In general, the method employs differential lysis between the cells of interest and other cells (e.g., other nucleated cells) in the sample. | 05-26-2016 |
20160151778 | Piston assembly and related systems for use with a fluidics device | 06-02-2016 |
20160151782 | FLUIDIC DEVICES AND FABRICATION METHODS FOR MICROFLUIDICS | 06-02-2016 |
20160158755 | CHIP FOR PRELIMINARY SAMPLE EVALUATION AND CELL COLLECTION - Disclosed is a chip for preliminary sample evaluation and cell collection. The chip for preliminary sample evaluation and cell collection includes: a substrate having a first hole formed in a first position and a second hole formed in a second position, the second hole being smaller in size than the first hole; and a mesh filter installed on a lower surface of the substrate in alignment with the first hole, the mesh filter having a plurality of filtering holes. The chip is capable of preliminarily evaluating a state or a property of a sample. If the sample is unacceptable, it is possible to replace the entire sample with a new sample and to take an additional measure so that the sample becomes acceptable. If the sample is acceptable, the next process is performed to collect cells contained in the sample. | 06-09-2016 |
20160167047 | FLOW CELL WITH AN INTEGRATED DRY SUBSTANCE | 06-16-2016 |
20160169781 | CELL-TRAPPING SYSTEM | 06-16-2016 |
20160178489 | SAMPLE PROCESSING SYSTEM AND METHOD | 06-23-2016 |
20160199834 | DISPOSABLE CARTRIDGE FOR SAMPLE FLUID ANALYSIS | 07-14-2016 |
20160199836 | CENTRIFUGAL CHANNEL DEVICE | 07-14-2016 |