Class / Patent application number | Description | Number of patent applications / Date published |
435294100 | Vessels or trays in series | 31 |
20080293133 | Textiles for use in bioreactors for expansion and maintenance of cells - A bioreactor for three-dimensional culture of liver cells is disclosed. The device is characterized by the use of textile vasculatures. A model and method for optimizing vasculature parameters is also disclosed. Liver acinar structure and physiological parameters are mimicked by sandwiching cells in the space between the two innermost woven textile hollow fibers, and creating radial flow of media from an outer compartment, through the cell mass compartment, and to an inner compartment. The theoretical optimum hydraulic permeability for the two innermost semi-permeable membranes is determined based on physiological hepatic sinusoidal blood flow and pressures. Experimental studies using a flow rate and pressure monitoring systems in conjunction with phase-contrast velocity-encoded MRI confirm theoretical results. Novel woven vascular tubes with optimum hydraulic permeability are disclosed for culturing hepatocytes in the multi-coaxial bioreactor. | 11-27-2008 |
20090047732 | BIODEGRADATION OF OXYANIONS SUCH AS PERCHLORATE ON ION EXCHANGE RESINS - Improved systems and methods for removing the load of perchlorate and other oxyanions off of ion exchange resins through bioregeneration are disclosed. The improved systems and methods rely upon direct contact between the resin and a liquid product containing enrichment cultures of or pure strains of perchlorate-destroying microorganisms. Controlled temperatures also lead to improvements as do upflow conditions leading to bed expansion. These methods can be incorporated into methods for removing perchlorate from aqueous streams. | 02-19-2009 |
20090191620 | LIMITED ACCESS MULTI-LAYER CELL CULTURE SYSTEM - The present invention provides a multi-layer cell culture device having a rectangular footprint and having multiple cell culture chambers separated by tracheal air spaces, each cell culture chamber having a port and a port cover or an external manifold structured and arranged to allow for transfer of fluid into and out of the cell culture device with reduced risk of contamination, and methods of using the device. | 07-30-2009 |
20090298163 | MULTILAYER CELL CULTURE VESSELS - A multilayered cell culture apparatus for the culturing of cells is disclosed. The cell culture apparatus includes a unitary flask body including a rigid upper and lower surface, connected by side walls. The cell growth apparatus comprises multiple cell growth chambers stacked in vertical alignment and orientation within the unitary flask body. The stacked chambers are held in position by unitary connecting columns that run through each cell growth chamber and terminate at the rigid upper and lower surfaces of the apparatus. The cell growth chambers are separated by tracheal spaces that allow air from the external environment to contact the cell growth surface of each individual cell growth chamber. | 12-03-2009 |
20090298164 | ASSEMBLY OF CELL CULTURE VESSELS - A cell culture apparatus includes a cell culture chamber formed by a first major surface, an opposing second major surface spaced apart from the first major surface, and a first side wall around the first chamber and extending between the first and second major surfaces. A portion of the first sidewall proximate the first major surface comprises an infrared absorbent material, and a portion the first sidewall proximate the second major surface is formed from substantially non-infrared absorbent material. The first major surface is formed by a gas permeable polymeric film that is impermeable to cell culture liquid. | 12-03-2009 |
20090317902 | CONTINUOUS PROCESS AND APPARATUS FOR ENZYMATIC TREATMENT OF LIPIDS - A method and system for the enzymatic treatment of a lipid containing feedstock comprises contacting the feedstock with a processing aid, then causing the feedstock to pass at a substantially constant flow rate through a treatment system comprising a plurality of enzyme-containing fixed bed reactors connected to one another in series. The fixed bed reactors can be individually serviceable, the flow rate of the feedstock remaining substantially constant through the system when one of the fixed bed reactors is taken offline for servicing. In the most preferred embodiment, the processing aid is a substantially moisture-free silica. The processing aid can be placed in one or more of the fixed bed reactors, disposed above the enzyme in the reactor, or it can be in a pre-treatment system which can comprise one or more reactors. | 12-24-2009 |
20100129900 | Layered Flask Cell Culture System - A multilayered cell culture apparatus for the culturing of cells is disclosed. The cell culture apparatus is defined as an integral structure having a plurality of flexible cell culture compartments in combination with a spacer material maintaining air space(s). The expandable compartments of the cell culture apparatus have imparted therein gas permeable membranes in combination with air spaces that will allow the free flow of gases between the cell culture compartments and the external environment. Furthermore an interconnecting passageway is provided between each compartment and between the cell culturing vessel and the external environment. The expandable vessel promotes the growth of large numbers of adherent or suspension cells by providing the volumes of nutrient medium and gaseous exchange. | 05-27-2010 |
20100233797 | BIO-WALL - A bioremediation device in the form of a cylindrical cartridge having an open mesh side wall and end-caps forming an enclosed volume and which contains a suitable media. The cartridge is removeably mounted in and supported on opposite sides by wall halves in the form of near semi-circular housing halves. The wall halves further contain inlet and outlet openings to permit a liquid and gaseous flow through the cartridge and the contained media. | 09-16-2010 |
20100279396 | MICRO-SCALED ANIMAL CELL INCUBATOR AND PRODUCTION METHOD THEREOF - There is provided a cell culture technology for culturing an animal cell in a separate microstructure. The micro-scaled animal cell incubator includes a lower glass substrate having fine hot wires processed with a metal and formed in an upper surface thereof; a first PDMS film attached onto the lower glass substrate to form two or more liquid and solid storage spaces in a position corresponding to the fine hot wires of the lower glass substrate and gas flow channels coupled respectively to the liquid and solid storage spaces to allow generated gases to flow therethrough; a gas-permeable PDMS thin film attached onto the gas flow channels of the PDMS film to pass the generated gases therethrough; a second PDMS film attached onto the PDMS thin film and having a culture medium storage space for storing a culture medium; and an upper glass substrate attached onto the second PDMS film and having fine hot wires formed in a lower surface thereof, the fine hot wires being covered by the PDMS film. The micro-scaled animal cell incubator may be useful to control a temperature of a culture medium to a suitable temperature level, as well as to self-supply gases required for the animal cell culture in a microstructure. | 11-04-2010 |
20100311157 | SYSTEMS AND METHODS FOR PRODUCTION OF BIOFUEL - Self-sustaining, self-contained systems and methods for producing biofuels and for producing biofuel feedstock from algae. The system is carbon neutral or may be carbon positive, fixing more carbon than it releases to the atmosphere. In various embodiments, the system may be coupled to an existing carbon dioxide producing process to reduce or completely eliminate carbon dioxide output, making the existing system carbon neutral, and providing valuable and tradable carbon credits. The system may also comprise modular tiles comprising a biomass sandwiched between two panels and use a combination of microbes, nutrients, water, and sunlight to generate biological hydrocarbon compounds that can be used in almost any type of engine. | 12-09-2010 |
20120115218 | BIOREACTOR COMPRISING A MIXING CHAMBER - The invention relates to a bioreactor ( | 05-10-2012 |
20130059370 | RECOVERY OF HIGHER ALCOHOLS FROM DILUTE AQUEOUS SOLUTIONS - This invention is directed to methods for recovery of C3-C6 alcohols from dilute aqueous solutions, such as fermentation broths. Such methods provide improved volumetric productivity for the fermentation and allows recovery of the alcohol. Such methods also allow for reduced energy use in the production and drying of spent fermentation broth due to increased effective concentration of the alcohol product by the simultaneous fermentation and recovery process which increases the quantity of alcohol produced and recovered per quantity of fermentation broth dried. Thus, the invention allows for production and recovery of C3-C6 alcohols at low capital and reduced operating costs. | 03-07-2013 |
20130183752 | DEVICE TO PRODUCE BIOGAS - A device to produce biogas that includes at least one fermenter ( | 07-18-2013 |
20130196424 | SACCHARIDE-SOLUTION PRODUCING APPARATUS, FERMENTATION SYSTEM, SACCHARIDE-SOLUTION PRODUCING METHOD, AND FERMENTATION METHOD - A saccharide-solution producing apparatus | 08-01-2013 |
20130323830 | Ensiling Biomass for Biofuels Production and Multiple Phase Apparatus for Hydolyzation of Ensiled Biomass - A method, apparatus and system for the hydrolyzation of ensiled biomass is disclosed. Ensiled biomass is processed in multiple phases, resulting in a liquid precursor hydrozate and a solid precursor hydrozate. The liquid precursor having significant economic value, and being suitable for uses such as, for example, lower cost and improved efficiency ethanol production. A method for lower cost, improved efficiency alcohol production that uses the resulting liquid precursor hydrozate being produced at distributed sources is further disclosed. | 12-05-2013 |
20130344585 | Devices and Methods for Integrated Continuous Manufacturing of Biological Molecules - The present invention relates to a process and apparatus for purifying a molecule of interest from a heterogeneous clarified fluid mixture. The apparatus of the invention generally comprises a continuous perfusion fermentation system, a continuous particle removal system integrated with the perfusion fermentation system; and a continuous purification system integrated with the particle removal system, which is maintained under sterile conditions. The process comprises filtering a heterogeneous clarified fluid mixture by continuous ultrafiltration at a specific flow rate below the transition point of the molecule of interest in the pressure-dependent region of the flux versus TMP curve, wherein the specific flow rate is maintained substantially constant throughout the continuous ultrafiltration. | 12-26-2013 |
20130344586 | PROCESSING BIOMASS - Biomass (e.g., plant biomass, animal biomass, and municipal waste biomass) is processed for use in the production of useful products, such as fuels. For example, systems can use biomass materials, such as cellulosic and/or lignocellulosic materials, to enhance the production of a product, e.g., the production of ethanol and/or butanol by fermentation. | 12-26-2013 |
20140087455 | Cell Culture Device and Transport Device - The present invention provides a carrier device including a culture vessel and a flow channel, which have a closed structure, for supplying cell liquid or a culture medium into the flow channel; and a method of aseptically injecting liquid, such as the cell or the culture medium, into the culture vessel and the flow channel. The present invention provides a carrier jig | 03-27-2014 |
20140106444 | MULTILAYERED CELL CULTURE APPARATUS - A multilayered cell culture apparatus for the culturing of cells is disclosed. The cell culture apparatus is defined as an integral structure having a plurality of cell culture chambers in combination with tracheal space(s). The body of the apparatus has imparted therein gas permeable membranes in combination with tracheal spaces that will allow the free flow of gases between the cell culture chambers and the external environment. The flask body also includes an aperture that will allow access to the cell growth chambers by means of a needle or cannula. The size of the apparatus, and location of an optional neck and cap section, allows for its manipulation by standard automated assay equipment, further making the apparatus ideal for high throughput applications. | 04-17-2014 |
20140113363 | PROCESS OF PRODUCING OIL FROM ALGAE USING BIOLOGICAL RUPTURING - A process for production of biofuels from algae can include cultivating an oil-producing algae, extracting the algal oil, and converting the algal oil to form biodiesel. Extracting the algal oil from the oil-producing algae can include biologically rupturing cell wall and oil vesicles of the oil-producing algae using at least one enzyme such as a cellulose or glycoproteinase, a structured enzyme system such as a cellulosome, a virus, or combination of these materials. | 04-24-2014 |
20140199759 | SYSTEMS AND METHODS FOR PRODUCTION OF ALGAL BIOMASS - Self-sustaining, self-contained systems and methods for producing biofuels and for producing biofuel feedstock from algae. The system is carbon neutral or may be carbon positive, fixing more carbon than it releases to the atmosphere. In various embodiments, the system may be coupled to an existing carbon dioxide producing process to reduce or completely eliminate carbon dioxide output, making the existing system carbon neutral, and providing valuable and tradable carbon credits. The system may also comprise modular tiles comprising a biomass sandwiched between two panels and use a combination of microbes, nutrients, water, and sunlight to generate biological hydrocarbon compounds that can be used in almost any type of engine. | 07-17-2014 |
20140315292 | Three Stage, Multiple Phase Anaerobic Digestion System and Method - A three stage, multiple phase anaerobic digestion system and method designed to separate the biological phases, optimize microbial activity in each phase, and significantly increase system reliability and energy production. The system physically separates the biological phases of anaerobic digestion based on particle size, particle density, and solubility of metabolic products. The system allows a complex multi-phased biological system to develop without the need for excessive control or operator intervention. | 10-23-2014 |
20140342444 | PRODUCTION APPARATUS OF SUGAR SOLUTION AND PRODUCTION SYSTEM OF SUGAR SOLUTION - A sugar solution production apparatus includes a saccharification tank that obtains a saccharified solution containing a solid substance from a cellulose-containing biomass, a solid-liquid separator that separates the solid substance from the saccharified solution to obtain a sugar solution, an enzyme recovery solution tank that stores an enzyme recovery solution, a sugar solution extraction line that extracts the sugar solution from the solid-liquid separator, a warm water supply unit that supplies warm water to the solid-liquid separator, an enzyme recovery solution supply line that supplies the enzyme recovery solution from the enzyme recovery solution tank to the solid-liquid separator, an enzyme recovery solution recovery line that feeds the enzyme recovery solution containing the saccharifying enzyme recovered from the solid substance to the enzyme recovery solution tank, and an enzyme recovery solution return line that returns the enzyme recovery solution to the saccharification tank. | 11-20-2014 |
20140342445 | ORGAN CHIPS AND USES THEREOF - Disclosed herein are organ chips that can be individually used or integrated together to form different microphysiological systems, e.g., for use in cell culturing, drug screening, toxicity assays, personalized therapeutic treatment, scaffolding in tissue repair and/or replacement, and/or pharmacokinetic or pharmacodynamics studies. | 11-20-2014 |
20140370587 | INTEGRATED SYSTEM FOR HYDROGEN AND METHANE PRODUCTION FROM INDUSTRIAL ORGANIC WASTES AND BIOMASS - The present invention provides a system that has been devised to overcome the two most important limitations for sustained biological hydrogen production, namely contamination of the microbial hydrogen-producing cultures with methane-producing cultures necessitating frequent re-start-up and/or other methanogenic bacteria inactivation techniques, and the low bacterial yield of hydrogen-producers culminating in microbial washout from the system and failure. The system includes a continuously stirred bioreactor (CSTR) for biological hydrogen production, followed by a gravity settler positioned downstream of the CSTR, which combination forms a biohydrogenator. The biomass concentration in the hydrogen reactor is kept at the desired range through biomass recirculation from the bottom of the gravity settler and/or biomass wastage from the gravity settler's underflow. The gravity setter effluent is loaded with volatile fatty acids, as a result of microbiological breakdown of the influent waste constituents by hydrogen-producing bacteria, and is an excellent substrate for methane-forming bacteria in the downstream biomethanator. | 12-18-2014 |
20150104862 | METHODS FOR GASIFICATION OF CARBONACEOUS MATERIALS - The present disclosure is generally directed to process of gasification of carbonaceous materials to produce synthesis gas or syngas. The present disclosure provides improved methods of gasification comprising: adding one or more carbonaceous materials, adding a molecular oxygen-containing gas, adding carbon dioxide gas and optionally adding water into said gasifier. This disclosure is also directed to process of production of one or more alcohols from said syngas via fermentation or digestion in the presence of at least one microorganism. | 04-16-2015 |
20150329813 | MULTILAYERED CELL CULTURE APPARATUS - A multilayered cell culture apparatus for the culturing of cells is disclosed. The cell culture apparatus is defined as an integral structure having a plurality of cell culture chambers in combination with tracheal space(s). The body of the apparatus has imparted therein gas permeable membranes in combination with tracheal spaces that will allow the free flow of gases between the cell culture chambers and the external environment. The flask body also includes an aperture that will allow access to the cell growth chambers by means of a needle or cannula. The size of the apparatus, and location of an optional neck and cap section, allows for its manipulation by standard automated assay equipment, further making the apparatus ideal for high throughput applications. | 11-19-2015 |
20160002582 | High Efficiency Biometric Device For Producing Hydrogen And Methane - A high efficiency biometric device for producing hydrogen and methane mainly uses a two-stage anaerobic fermentation device to transform an organic wastewater mixed solution into hydrogen, methane, carbon dioxide and a removal liquid, and then uses a solid liquid separation tank to filter and separate the removal liquid to reduce the sludge and obtain the treated water with a good property. The characteristic lies in that the two-stage anaerobic fermentation device comprises a first anaerobic fermentation tank, a neutralization tank, a feeding tank and a second anaerobic fermentation tank composed of anaerobic fermentation tanks disposed in parallel. The biometric device can increase the removal rate and the methane recovery, and also has a generator for combusting the recycled gas to advantageously have the low energy consumption. Thus, the organic waste contamination is decreased, and the green energy production pathway is also increased. | 01-07-2016 |
20160040110 | Bioreactor for the Cultivation of Mammalian Cells - The present invention relates to large-scale bioreactors having at least two impellers, large-scale bioreactor systems and methods for the large scale cultivation and propagation of mammalian cells using these bioreactors. | 02-11-2016 |
20160068794 | INTEGRATED SYSTEM FOR HYDROGEN AND METHANE PRODUCTION FROM INDUSTRIAL ORGANIC WASTES AND BIOMASS - The present invention provides a system that has been devised to overcome the two most important limitations for sustained biological hydrogen production, namely contamination of the microbial hydrogen-producing cultures with methane-producing cultures necessitating frequent re-start-up and/or other methanogenic bacteria inactivation techniques, and the low bacterial yield of hydrogen-producers culminating in microbial washout from the system and failure. The system includes a continuously stirred bioreactor (CSTR) for biological hydrogen production, followed by a gravity settler positioned downstream of the CSTR, which combination forms a biohydrogenator. The biomass concentration in the hydrogen reactor is kept at the desired range through biomass recirculation from the bottom of the gravity settler and/or biomass wastage from the gravity settler's underflow. The gravity setter effluent is loaded with volatile fatty acids, as a result of microbiological breakdown of the influent waste constituents by hydrogen-producing bacteria, and is an excellent substrate for methane-forming bacteria in the downstream biomethanator. | 03-10-2016 |
20160152937 | APPARATUS AND PROCESS FOR CONTINUOUS SACCHARIFICATION OF MARINE ALGAE AND CELLULOSIC BIOMASS | 06-02-2016 |