Class / Patent application number | Description | Number of patent applications / Date published |
435285100 | Mutation or genetic engineering apparatus | 35 |
20080274537 | Tool Head for an Apparatus for the Automatic Isolation and Treatment of Cell Clones - The invention relates to a tool head for a device that is used to automatically isolate and treat cell clones by means of a cloning dome, which isolates the respective cell clone from the environment, said cloning dome being held in a detachable manner by the tip of a pipette and the latter being fixed by a non-positive fit to a conical receiving element of the tool head. To hold the cloning dome on the tip of the pipette, the latter comprises a conical section, over which a complementary conical section of the cloning dome is folded and the tool head is fixed to an arm of a robot system. According to the invention, the end of the arm that is located on the tool head side is equipped with a receiving block ( | 11-06-2008 |
20080299647 | Cell capturing plate, microinjection apparatus, and method of producing cell capturing plate - A cell capturing plate has a flat surface, an opening formed in one surface of the flat surface and supporting the cell therein, and a through-hole penetrating from the opening to the other surface of the flat surface and having a cross section parallel to the flat surface smaller than that of the opening. | 12-04-2008 |
20090011494 | Method for controlling biological function with mechanical vibration and device therefor - Methods and apparatus for controlling biological functions with mechanical vibration are provided. Stimulation is applied to cells of one of an organism, bacteria or virus by mechanical vibration. The biological function comprises biological functions relating to cell growth. The biological functions relating to cell growth may include at least one of cell cultivation, cell proliferation, cell fusion, and cell differentiation. | 01-08-2009 |
20090029449 | METHOD AND APPARATUS FOR SUBSTANTIALLY ISOLATING PLANT TISSUES - The present invention discloses and claims methods and devices for the rapid mechanical isolation of monocot plant tissues suitable for transformation or tissue culture. The invention includes mechanical devices for substantially isolating target plant tissues for use as transformable explants, and propagation of transgenic plants and plant tissues. | 01-29-2009 |
20090104686 | Apparatus for Thin-Layer Cell Smear Preparation and In-situ Hybridization - The present invention discloses an apparatus for thin-layer cell smear preparation and in-situ hybridization, comprising at least one positioning device and a sealing device. The positioning device comprises at least one first opening. When the positioning device is set on a carrier device, the wall of the first opening and the carrier device form a cavity. The cavity is used to accommodate a cell suspension. The sealing device is provided on the positioning device for sealing the cavity to form an enclosed space. | 04-23-2009 |
20090130743 | Vibration type microinjection device - A vibration type microinjection device capable of ensuring smooth piercing of membranes having different properties such as a zona pellucida, a cell membrane and a nuclear membrane included in a fertilized egg with high accuracy and efficiency is provided. | 05-21-2009 |
20100129896 | SYSTEM FOR DIFFERENTIATING THE LENGTHS OF NUCLEIC ACIDS OF INTEREST IN A SAMPLE - Systems for differentiating the lengths of nucleic acids of interest in a sample are provided. The system includes a microfluidic device, a detector, and a software system. The microfluidic device includes an amplification microchannel or microchamber containing a reaction mixture under conditions that provide one or more amplicons of the nucleic acid of interest. The detector is integral with or proximal to the microfluidic device and is configured to detect the amplicons as one or more signals from a homogenous mixture. The software system interprets one or more coincidentally detected signals to indicate lengths of one or more individual nucleic acid molecules of interest, thereby differentiating the lengths of the nucleic acids of interest. | 05-27-2010 |
20100248339 | TIP DRIVE APPARATUS - A tip, drive apparatus is capable to moving a tip unit toward an object, while holding the tip unit at a prescribed angle. The tip unit is formed on a support unit having flexibility and directed to the object at the prescribed angle. The tip drive apparatus includes a needle having a shaft to which the support unit on which the tip unit is formed, and an adaptor configured to hold the needle, enabling the needle to be replaced by another. The adaptor is configured to be able to change a positional relation with respect to the main unit of the tip drive apparatus, while the needle is being attached. | 09-30-2010 |
20100248340 | NEEDLE - A needle designed to be manipulated on a single cell includes a cantilever tip including a support unit and a tip unit formed at a prescribed angle to the support unit, and a shaft connected to the cantilever tip. The needle is attachable, via at least the shaft, to a tip drive apparatus capable of moving the tip unit in a prescribed direction. | 09-30-2010 |
20100248341 | TIP DRIVE APPARATUS - A tip drive apparatus includes a shaft to which a support unit on which a tip unit is formed, and a main unit configured to move the shaft, thereby to move the tip unit toward an object while remaining held at a prescribed angle. The shaft is arranged to meet four requirements including a first requirement of being prevented from contacting a condenser lens of an inverted microscope to which the main unit is attached, a second requirement of providing a region in which a distal end of the support unit is recognized, a third requirement of being prevented from contacting a sidewall of a dish for holding the object, and a fourth requirement of providing a region in which the dish moves relative to the tip unit. | 09-30-2010 |
20100248342 | TIP DRIVE APPARATUS AND CANTILEVER TIP - A tip drive apparatus is capable to moving a tip unit toward an object, while holding the tip unit at a prescribed angle. The tip unit is formed on a support unit having flexibility and directed to the object at the prescribed angle. The tip unit includes a contact side in a cross section including the distal end of the support unit and extending in the direction the support unit extends, the contact side configured to contact, at one part at least, the object, and to apply a prescribed pressure to the object. The tip unit further includes a first region including the contact side, and a second region continuous to the support unit. | 09-30-2010 |
20110165664 | TRANSFECTION DEVICE UTILIZING SERICIN - There is provided a transfection device having a mixture ( | 07-07-2011 |
20130005025 | Multiplex Automated Genome Engineering - The present invention relates to automated methods of introducing multiple nucleic acid sequences into one or more target cells. | 01-03-2013 |
20130102060 | LANCE DEVICE AND ASSOCIATED METHODS FOR DELIVERING A BIOLOGICAL MATERIAL INTO A BIOLOGICAL STRUCTURE - Systems, devices, and methods for delivering a biological material into a biological structure are provided. In one aspect, for example, a lance device for introducing biological material into a biological structure and configured for use in a nanoinjection system including a microscope is provided. Such a device can include a substrate including a handle region located between a manipulator coupling region and a lance shaft region, a lance tip operable to introduce biological material into a biological structure, the lance tip being coupled to the lance shaft region, and an electrically conductive layer extending from the manipulator coupling region to the lance tip, the conductive layer being configured to electrically couple to a power source. Thus, the conductive layer provides an electrical connection from the power source to the lance tip when in use. | 04-25-2013 |
20130164828 | OPTICAL TRANSFECTION - An integrated fibre based device for transfecting material into a cell comprising an optical fiber that has a lens formed at its end for directing light to a surface of the cell, and a channel for delivery of the material for transfection into the cell. | 06-27-2013 |
20130210123 | BIOMATERIAL HANDLING DEVICE - A biomaterial handling device is described that will provide for functionality for performing both IVF procedures and washing techniques in a single device. Disclosed embodiments provide increased protection to biomaterial samples during processing and handling. Embodiments of the invention reduce labor intensive processes for both IVF and washing treatments and address reduced risks of contamination of biological samples by providing an increasingly sterile environment. | 08-15-2013 |
20140093946 | SYSTEM FOR OPTIMIZING THE INTRODUCTION OF NUCLEIC ACIDS INTO CELLS USING MAGNETIC PARTICLES - An embodiment of a system is provided herein, wherein the system allows for the analysis and selection of numerous experimental conditions to optimize transfection efficiency and cell viability. The system is used for magnetic particle based nucleic acid delivery by optimizing various parameters. The system comprises a control module; an incubation module for incubating magnetic nanoparticle and nucleic acid; a transfection module and an analysis module. | 04-03-2014 |
20140273180 | SYSTEMS AND METHODS FOR DETECTION OF CELLS USING ENGINEERED TRANSDUCTION PARTICLES - Systems and methods for detecting and/or identifying target cells (e.g., bacteria) using engineered transduction particles are described herein. In some embodiments, a method includes mixing a quantity of transduction particles within a sample. The transduction particles are associated with a target cell. The transduction particles are non-replicative, and are engineered to include a nucleic acid molecule formulated to cause the target cell to produce a series of reporter molecules. The sample and the transduction particles are maintained to express the series of the reporter molecules when target cell is present in the sample. A signal associated with a quantity of the reporter molecules is received. In some embodiments, a magnitude of the signal is independent from a quantity of the transduction particle above a predetermined quantity. | 09-18-2014 |
20140315282 | MICROINJECTOR MOUNTING MODULE AND NEEDLE-HOLDER COMPONENT - A microinjector needle mounting module and a needle holder assembly, comprising a micro-injection needle ( | 10-23-2014 |
435285200 | With means for applying an electric current or charge (e.g., electrofusion, electroporation, etc.) | 11 |
20090061504 | Apparatus for Performing Magnetic Electroporation - An apparatus for performing magnetic electroporation is disclosed. A required electric field for electroporation is generated using a pulsed magnetic field through a closed magnetic yoke, such as a toroid, placed in a flow path of a fluid medium to be processed. The fluid medium flows through the orifice of the magnetic yoke, with the fluid medium flowing through and around the yoke. The required power to send a maximum flux through the magnetic yoke is less than the required power in a conventional apparatus for performing electroporation. | 03-05-2009 |
20090087900 | Apparatus for Performing Electrodistention on Algae Cells - Two apparatuses capable of performing electroporation are disclosed. The first apparatus uses a Marx generator with a substantial change from its original waveform. The second apparatus does not use a Marx generator. | 04-02-2009 |
20100068794 | Cell Fusion Chip - (Problems) To provide a cell fusion chip, which allows to perform a cell fusion on a single chip, excels in the operating efficiency, does not require experience so much in cell feed or recovery, and has no risk of the contamination to the cells during the operation. | 03-18-2010 |
20100196998 | SYSTEM AND METHOD FOR ELECTROPORATING A SAMPLE - A system and method are described for electroporating a sample that utilizes one or more sets of electrodes that are spaced apart in order to hold a surface tension constrained sample between the electrodes. The first electrode is connected to the lower body of the system while the second electrode is connected to the upper body. Both electrodes are connected to a pulse generator. Each electrode has a sample contact surface such that the first electrode and the second electrode may be positioned to hold a surface tension constrained sample between the two sample contact surfaces and the sample may receive a selected electric pulse. | 08-05-2010 |
20110065171 | METHODS AND DEVICES RELATED TO A REGULATED FLOW ELECTROPORATION CHAMBER - The electroporation chamber and its related devices combine the features of an electroporation chamber that acts as a manifold for regulation of sample flow with those of a flow electroporation device to form a regulated flow electroporation device. The invention further comprises a novel regulated flow electroporation chamber that enables conditions in which a sample is uniformly processed in individual fractions or volumes in a fully closed (sterile) system. | 03-17-2011 |
20140057337 | SYSTEM AND METHOD FOR ELECTROPORATING A SAMPLE - A system and method are described for electroporating a sample that utilizes one or more sets of electrodes that are spaced apart in order to hold a surface tension constrained sample between the electrodes. The first electrode is connected to the lower body of the system while the second electrode is connected to the upper body. Both electrodes are connected to a pulse generator. Each electrode has a sample contact surface such that the first electrode and the second electrode may be positioned to hold a surface tension constrained sample between the two sample contact surfaces and the sample may receive a selected electric pulse. | 02-27-2014 |
20140363881 | MODULAR ADJUSTABLE PULSE GENERATOR - A pulse generation system for applying electric pulses across a load includes a first plurality of energy storage modules connected in series on a positive chain and configured to apply a positive potential to the load and a second plurality of energy storage modules connected in series on a negative chain and configured to apply a negative potential to the load. Each energy storage module of the positive chain and the negative chain includes a rectifier and a storage element, and at least one control element. | 12-11-2014 |
20150093813 | Electroporator Having an Elongated Hollow Member - An electroporation apparatus comprising an elongated hollow member in order to provide a uniform electric field during electroporation, wherein specifically, electroporation is carried out by applying electric pulses through a couple of electrodes from both end parts of the elongated hollow member, after the hollow member is charged with fluid specimen including cells and material which would be injected into the cells. | 04-02-2015 |
20150147803 | Coatings of Semiconductor Quantum Dots for Improved Visibility of Electrodes and Pipettes - A glass pipette such as an electrode for electrophysiological recording is coated with quantum dots. This greatly aids the ability to observe the glass pipette, particular in tissue as the quantum dots provide an excellent performance under two-photon illumination used to visualize objects at depths of hundreds of microns. | 05-28-2015 |
20160137966 | A High Density Distributed Three-dimensional Electrode Device - A high-density distributed three-dimensional electrode device, comprising an electrode array and an electrode fixing assembly on which the electrode array is fixed, the electrode array comprising a plurality of electrodes respectively applied with an electric pulse of a first polarity and an electric pulse of a second polarity according to a time period, wherein the electrodes corresponding to the electric pulse of the second polarity are distributed around the electrodes corresponding to the electric pulse of the first polarity. | 05-19-2016 |
20160194594 | System and Method for Electroporating a Sample | 07-07-2016 |
435285300 | Including projectile means | 5 |
20090017527 | ADVANCED GENETIC VACCINES - Reagents useful in nucleic acid immunization techniques are described. More particularly, adjuvanted genetic vaccine compositions are described, as are methods of using those compositions for inducing an enhanced immune response against a selected antigen. | 01-15-2009 |
20100248343 | Methods and Devices for Charged Molecule Manipulation - Devices and methods for constraining or holding a cell are provided. In one aspect, for example, a cellular constraint device is provided. Such a device can include a support surface and at least one constraining arm movably coupled to the support surface. The constraining arm has a first position in which the constraining arm is substantially parallel and substantially adjacent to the support surface. Additionally, at least a portion of the constraining arm is movable away from the support surface to a second position where the constraining arm is operable to constrain a single cell. | 09-30-2010 |
20110159577 | DIVIDER FOR USE WITH BIOLISTIC BOMBARDMENT DEVICE - The present invention is designed for use with a biolistic bombardment device having a cold gas shock wave splitter that divides a cold gas shock wave into two or more separate pressure waves that burst into one or more macrocarrier disks so as to create two or more separate microparticle groups. In various embodiments, the present invention provides a divider that is configured to define two or more separate bombardment areas, each configured to contain a respective target and to receive a separate one of the microparticle groups created by a cold gas shock wave splitter. In such a manner, the present invention avoids mixing of microparticles between microparticle groups and allows for independent biolistic bombardment of the targets. | 06-30-2011 |
20140099702 | DIVIDER FOR USE WITH BIOLISTIC BOMBARDMENT DEVICE - The present invention is designed for use with a biolistic bombardment device having a cold gas shock wave splitter that divides a cold gas shock wave into two or more separate pressure waves that burst into one or more macrocarrier disks so as to create two or more separate microparticle groups. In various embodiments, the present invention provides a divider that is configured to define two or more separate bombardment areas, each configured to contain a respective target and to receive a separate one of the microparticle groups created by a cold gas shock wave splitter. In such a manner, the present invention avoids mixing of microparticles between microparticle groups and allows for independent biolistic bombardment of the targets. | 04-10-2014 |
20140178974 | TRANSPORTATION DEVICE - A transportation device, transporting a material to a target, includes an input module, a transmission module and an output module. The input module has a containing unit and at least one filter. The at least one filter is connected to the containing unit, and a carrier fluid and the material are stored in the containing unit. The transmission module is coupled to the at least one filter of the input module. The output module has a guiding unit, a throat portion, a first opening and a second opening. The throat portion is positioned between the first opening and the second opening. One end of the guiding unit is connected to the transmission module. The other end of the guiding unit has a guiding corner for connecting to the first opening. The material will enter the output module through the first opening and reaches the target through the second opening. | 06-26-2014 |