Inventors list

Assignees list

Classification tree browser

Top 100 Inventors

Top 100 Assignees


APPARATUS

Subclass of:

435 - Chemistry: molecular biology and microbiology

Patent class list (only not empty are listed)

Deeper subclasses:

Class / Patent application numberDescriptionNumber of patent applications / Date published
435287100 Including measuring or testing 741
435289100 Bioreactor 487
435286100 Including condition or time responsive control means 121
435284100 Differentiated tissue (e.g., organ) perfusion or preservation apparatus 37
435307100 Microorganism preservation, storage, or transport apparatus 34
435309100 Inoculator, streaker, or sampler 29
435285100 Mutation or genetic engineering apparatus 23
435308100 Means for separation or recovery of a microorganism from culture media 15
435306100 Involving lysis of a microorganism by means other than comminution 9
Entries
DocumentTitleDate
20110201097Ionic Liquid Apparatus and Method for Biological Samples - Apparatus and method for handling biological samples. Segments of ionic liquid can provide voltage across segments of immiscible liquid to concentrate or separate charged species in the biological samples. Reactants in biological samples can be contacted and reacted in segments of immiscible liquid.08-18-2011
20110195489System and Method of an In-vitro Wound Healing Model on Cultured Cell Monolayer Employing Stamp Device - A system and method of an in vitro wounding model that employs a wounding device compromising a stamp assembly with a stamp disk engraved with alternating grooves and ridges, to dislodge cells of cultured cell monolayer. Strips or islands of cells are left behind, which can be used for morphological observation in biological research. Further and more importantly, these strips or islands of cells can be designed to be sufficiently narrow or small (˜100 μm) to ensure that all remaining cells become rapidly activated and then migrate, dedifferentiate and proliferate in near synchrony, so that samples can be collected in large amount which is suitable for biochemical studies.08-11-2011
20110195488DEVICES FOR COLLECTION AND STABILIZATION OF BIOMARKERS IN LIQUID SAMPLES - Device for collection and stabilization of biomarkers in liquid samples. In at least one embodiment of a fluid collection device, the device comprises a first tube operable to receive a body fluid, a second tube operable to dispense a body fluid, and a suction device operably connected to the second opening of the first tube and the first end of the second tube, wherein the suction device is operable to produce negative pressure through the first tube and is operable to exert positive pressure through the second tube. An embodiment of the devices also comprises a stabilizing agent contained within the fluid collection device, the stabilizing agent capable of completely or substantially preventing the degradation or inactivation of a diagnostic agent in a body fluid upon receipt of the body fluid into the fluid collection device.08-11-2011
20110195487SAMPLE CONTAINER FOR BIOMARKER MAINTENANCE - Sample container for biomarker maintenance. In at least one embodiment of a system for stabilizing a diagnostic marker of the present disclosure, the system comprises a sample container having an opening and least one rigid chamber for containing a body fluid, the body fluid comprising at least one diagnostic marker, a stabilizing agent contained within the sample container, the stabilizing agent capable of completely or substantially preventing the degradation or inactivation of the diagnostic marker, and a securing device for closing the opening of the sample container, wherein the stabilizing agent is coupled to a solid support. In an exemplary embodiment of a system of the present disclosure, the stabilizing agent may be adsorbed to the solid support.08-11-2011
20130084627BIOCHIP - There is provided a biochip including a first substrate having micro wells formed to a predetermined depth and partitioned by a plurality of barrier ribs, and a reservoir formed below the micro wells and receiving liquid; and a second substrate coupled with the first substrate to thereby allow biomaterials provided thereon to be inserted into the micro wells while having a predetermined interval therebetween.04-04-2013
20100099171VITRIFICATION APPARATUS FOR MICRODROP VITRIFICATION OF CELLS AND A METHOD OF MICRODROP VITRIFICATION OF CELLS USING THE APPARATUS - An apparatus for microdrop vitrification has a tank and two wings. The tank has a bottom, two side edges, two top edges, two sidewalls, a lowest bottom, a drain and a spout. The drain is defined in one of the sidewalls at the bottom of the tank. The spout is mounted on the bottom of the tank and is connected to the drain. The wings are integrally formed respectively with and extend out from the top edges. The present invention also relates to a microdrop forming device, a method for microdrop vitrification and a method for recovering vitrified cells.04-22-2010
20120164715DEVICE FOR PORCESSING A CYTOLOGICAL OR HISTOLOGICAL PREPARATION - A device for processing a cytological or histological preparation includes: a carousel, including at least one space for receiving a slide for receiving a cytological or histological preparation, the carousel being rotatably mounted about an axis of rotation; a nebulizing head that passes above the carousel, including the piezoelectric element and a space for the reagent such that the nebulising head expels at least one drop of reagent as a result of the deformation of the piezoelectric element.06-28-2012
20120225473Devices And Method For Enrichment And Alteration Of Cells And Other Particles - The invention features devices and methods for the deterministic separation of particles. Exemplary methods include the enrichment of a sample in a desired particle or the alteration of a desired particle in the device. The devices and methods are advantageously employed to enrich for rare cells, e.g., fetal cells, present in a sample, e.g., maternal blood and rare cell components, e.g., fetal cell nuclei. The invention further provides a method for preferentially lysing cells of interest in a sample, e.g., to extract clinical information from a cellular component, e.g., a nucleus, of the cells of interest. In general, the method employs differential lysis between the cells of interest and other cells (e.g., other nucleated cells) in the sample.09-06-2012
20110020917NANOFIBERS CONTAINING LATENT REACTIVE GROUPS - A nanofiber is formed by combining one or more natural or synthetic polymeric materials and one or more than one cross-linking agents having at least two latent reactive activatable groups. The latent reactive activatable nanofiber may be used to modify the surface of a substrate by activating at least one of the latent reactive activatable groups to bond the nanofiber to the surface by the formation of a covalent bond between the surface of the substrate and the latent reactive activatable group. Some of the remaining latent reactive activatable group(s) are left accessible on the surface of the substrate, and may be used for further surface modification of the substrate. Biologically active materials may be immobilized on the nanofiber modified surface by reacting with the latent reactive groups that are accessible on the surface of the substrate.01-27-2011
20090233349Metal Nanowires With An Oxide Sheath And Production Method For Same - A one-dimensional composite structure which comprises at least one nanowire. The nanowire comprises a metal core and a metal oxide sheath.09-17-2009
20090011493DEVICE CONTAINING CYTOPHILIC ISLANDS THAT ADHERE CELLS SEPARATED BY CYTOPHOBIC REGIONS - The invention provides a device for adhering cells in a specific and predetermined position, and associated methods. The device includes a plate defining a surface and a plurality of cytophilic islands that adhere cells, isolated by cytophobic regions to which cells do not adhere, contiguous with the cytophilic islands. The islands or the regions or both may be formed of a self-assembled monolayer (SAM).01-08-2009
20080293127Method to Render Pressure Sensitive Adhesive Compatible with Polymerase Chain Reaction Systems - A method for substantially eliminating a cross-linking element of a pressure sensitive adhesive by heating the pressure sensitive adhesive at a temperature of at least 180° C. for a period of time required to thermally decompose the cross-linking element of the pressure sensitive adhesive.11-27-2008
20110300610Thermally Conductive Microplate - Embodiments according to the present teachings of a microplate comprising a main body portion having a first surface and an opposing second surface are disclosed. A plurality of wells are formed in the first surface, each of the plurality of wells being sized to receive an assay therein. A backing is coupled to the opposing second surface of the main body portion.12-08-2011
20110300609NUCLEIC ACID EXTRACTION APPARATUS - The present invention relates to a nucleic acid extracting apparatus, and the nucleic acid extracting apparatus can include a pipe-shaped tube having an open outlet at one side thereof, and a hydrogel supporting member that is provided inside the tube and filters impurities excluding an extraction target material.12-08-2011
20110124093CONSTANT-TEMPERATURE EQUIPMENT - Provided is constant-temperature equipment wherein maintenance is facilitated with the least failure, and highly reliable culturing and testing can be carried out. Mechanical and electrical structures are eliminated from the inside of a temperature-controlled chamber (05-26-2011
20090098640METHOD AND APPARATUS FOR PREPARING CELLS FOR MICROTOME SECTIONING AND ARCHIVING NUCLEIC ACIDS AND PROTEINS - A method and apparatus for embedding cells that utilizes a flow-through embedding technique maximizes the efficiency of extractions and decreases time for embedding the cell fragments, minimizes cell loss, and automatically positions cell samples at the position in which a microtome blade will section them. The apparatus includes a cell flow pathway defined by an inflow tube for delivering cell fragments from a cell sample to a sample port. The sample port is in fluid communication with a tissue cassette having attached thereto a filter. The cell flow pathway is in communication with a reagent flow pathway for delivering the reagents through the sample port to the cassette. The apparatus is configured such that the application of pressure directs the cell fragments from the cell sample through the cell flow pathway, and effects delivery of the reagents through the reagent flow pathway. The apparatus produces an embedded cell block having concentrated cells near the plane of the block to be sectioned in a quick and efficient manner.04-16-2009
20100112677STERILE ENVIRONMENT MAINTAINING APPARATUS - Provided is a sterile environment maintaining apparatus capable of sterilizing a sterile room in a shorter time than conventional ones.05-06-2010
20100120130Droplet Actuator with Droplet Retention Structures - The present invention is directed to droplet actuators with droplet retention structures, and methods related thereto. In an exemplary embodiment, the invention provides a droplet actuator with one or more substrates arranged to form a droplet operations gap comprising gap-facing surfaces; droplet operations electrodes configured to conduct droplet operations in the droplet operations gap; at least one barrier included on at least one of the substrate surfaces and having dimensions selected to: permit droplet transport from atop a first droplet operations electrode to a second droplet operations electrode when the second droplet operations electrode is activated; and prevent movement of a droplet from atop a first droplet operations electrode when the first and second droplet operations electrodes are inactive.05-13-2010
20100273243NOZZLE DEVICE AND LIQUID SAMPLE ANALYZER - A nozzle device which can perform accurate quantitative suction without being affected by a pressure when, for example, a nozzle (10-28-2010
20130217100Apparatus for Embedding Tissue Samples - A histology tissue embedding apparatus including a reservoir for an embedding medium and an outlet valve connected to the reservoir through which the embedding medium is dispensable, and including trigger means which control the operation of the outlet valve, the trigger means having a rest position in which the outlet valve is closed, wherein the rest position of the trigger means in relation to the outlet valve is adjustable.08-22-2013
20090162925CELL/TISSUE MASS SELECTING APPARATUS AND DIVIDING MECHANISM THEREOF - A selecting apparatus for selecting cell/tissue mass includes a base, a feeding mechanism and a dividing mechanism. The base has a platform for placing the cell/tissue mass. The feeding mechanism, disposed on the base, moves relative to the platform. The dividing mechanism, disposed on the feeding mechanism, includes a first cutting set and a second cutting set connected therewith. The second cutting set reciprocally moves between a first position and a second position, toward the first cutting set. The feeding mechanism moves the dividing mechanism above the platform, aligning the dividing mechanism with a portion of the cell/tissue mass, and moves the first cutting set toward the cell/tissue mass, cutting into the portion of the cell/tissue mass. The second cutting set moves from the first position to the second position, limiting the portion of the cell/tissue mass between the first cutting set and the second cutting set.06-25-2009
20090286306SAMPLE CHAMBER VOLUME REDUCER - An apparatus includes a chamber insert capable of being received by a sample chamber of a conditioning system. The received chamber insert reduces the volume of the sample chamber and defines a cavity that substantially surrounds a sample holder located in the sample chamber.11-19-2009
20090035844Mechanical cell wounder device and related method - Disclosed is a device and related method for biological manipulation. With greater particularity, disclosed is a novel device and method for uniform cellular manipulation with economies of scale and operational uniformity. The device and related method utilize a cellular wounder (02-05-2009
20080286856Nanostructure Enhanced Luminescent Devices - The present invention relates to nanostructures for use in luminescent devices.11-20-2008
20100144018AUTOMATED SLIDE STAINING APPARATUS - A slide stainer assembly is disclosed. The slide stainer includes a slide carrier that is configured to carry one or more laboratory slides and a plurality of slide processing stations for processing the slides. A transport member including a plurality of engagement portions is configured for releasably engaging the slide carrier. A drive mechanism is coupled to the transport member. The drive mechanism is configured to move the transport member in a cyclical path such that, in the course of one cycle, the transport member engages a slide carrier docked in a first station, removes the slide carrier from the first station, docks the slide carrier in a second station and returns to the first station to engage another slide carrier.06-10-2010
20100248338CELL TREATMENT DEVICE, CELL TREATMENT CARTRIDGE AND BODY FLUID TREATMENT SYSTEM - A cell treatment device which allows cell dispersion liquid including cancer cells to pass therethrough to cause at least the cancer cells to be subjected to at least one of a physical action, a chemical action, and a biologically activating action, includes: a slit member having a first surface and a second surface and including a through hole having a slit shape penetrating from the first surface to the second surface and extending in one direction, the through hole having a tapered portion, wherein the width of a cross section of the tapered portion orthogonal in the one direction reduces from the first surface toward the second surface side, and is smaller than an average diameter of the cancer cells at an end on the second surfaces side, and the cell dispersion liquid is allowed to pass from the first surface side through the through hole to the second surface side.09-30-2010
20120094365MOLECULAR MOTOR - A molecular motor in which multiple concentric cylinders (or nested cones) rotate around a common longitudinal axis. Opposing complementary surfaces of the cylinders or cones are coated with complementary motor protein pairs (such as actin and myosin). The actin and myosin interact with one another in the presence of ATP to rotate the cylinders or cones relative to one another, and this rotational energy is harnessed to produce work. The length of the cylinders can also be used to control the power generated by the motor. In another embodiment, the molecular motor includes at least two annular substrates wherein one annular substrate is coated with a first motor protein and the other annular substrate is coated with a second motor protein. The first and second motor proteins interact with each other to move the second annular relative to the first annular substrate.04-19-2012
20090325273MULTI-FUNCTIONAL TREATING DEVICE FOR TREATING PATHOLOGICAL TISSUE SECTIONS - A multi-functional treating device for pathological tissue sections includes a main body provided with at least one accommodating chamber formed in its top portion and a central controller. A water bath, an oven, a paraffin scrubber and a section baking rack are respectively installed in each of the accommodating chambers. The central controller is provided with plural control buttons, which are respectively connected with an electrothermal device installed under the paraffin scrubber, the water bath, the oven and the section baking rack respectively. Thus, the multi-functional treating device can simultaneously do jobs of scrubbing off extra paraffin, wetting tissue sections, primarily drying up tissue sections, and drying up slides carrying the sections, saving a lot of space.12-31-2009
20090098639APPARATUS FOR EXECUTION OF TREATMENT OPERATIONS IN CONNECTION WITH COLOURING OF TISSUE SPECIMENS ON OBJECT GLASSES - An apparatus for automatic execution of different treatment operations in connection with staining of tissue specimens on microscope slides, wherein the apparatus (04-16-2009
20080318305IN SITU HEAT INDUCED ANTIGEN RECOVERY AND STAINING APPARATUS AND METHOD - An automated in situ heat induced antigen recovery and staining method and apparatus for treating a plurality of microscope slides. The process of heat induced antigen recovery and the process of staining the biological sample on the microscope slide are conducted in the same apparatus, wherein the microscope slides do not need to be physically removed from one apparatus to another. Each treatment step occurs within the same reaction compartment. The reaction conditions of each reaction compartment for treating a slide can preferably be controlled independently, including the individualized application of reagents to each slide and the individualized treatment of each slide. The reagents are preferably held in a reagent dispensing strip similar to a “blister pack”.12-25-2008
20100261261CELL/TISSUE MASS SELECTING APPARATUS AND DIVIDING MECHANISM THEREOF - A selecting apparatus for selecting cell/tissue mass includes a base, a feeding mechanism and a dividing mechanism. The base has a platform for placing the cell/tissue mass. The feeding mechanism, disposed on the base, moves relative to the platform. The dividing mechanism, disposed on the feeding mechanism, includes a first cutting set and a second cutting set connected therewith. The second cutting set reciprocally moves between a first position and a second position, toward the first cutting set. The feeding mechanism moves the dividing mechanism above the platform, aligning the dividing mechanism with a portion of the cell/tissue mass, and moves the first cutting set toward the cell/tissue mass, cutting into the portion of the cell/tissue mass. The second cutting set moves from the first position to the second position, limiting the portion of the cell/tissue mass between the first cutting set and the second cutting set.10-14-2010
20100216221DEVICE WITH WHICH A HISTOLOGICAL SECTION GENERATED ON A BLADE OF A MICROTOME CAN BE APPLIED TO A SLIDE - A device for applying a histological section to a slide is described. The histological section is generated by a cutting action performed by a blade of a microtome. The device comprises a positioning device having a component that is rotatably mounted to a bearing and has a receptacle for receiving and holding the slide, wherein the positioning device is designed such that the slide received in the receptacle can be rotated about an axis of rotation of the rotatably mounted component.08-26-2010
20100255563CONTAINER AND ANALYSIS CONTAINER USING THE SAME - A vessel, which can easily be opened and closed without detaching and attaching a cover, is provided. The vessel of the present invention includes a vessel body 10-07-2010
20090075359Apparatus and method for encapsulating pancreatic cells - An apparatus and method for coating micron-sized or sub-micron-sized particles such as living cells. The coating apparatus includes an encapsulation chamber enclosing a two-layer water-oil system for coating each islet cell with an aqueous polymeric coat. Islets together with an aqueous polymer solution are fed by a feed device that utilizes the principle of hydrodynamic focusing in order to ensure encapsulation of individual islets. The polymer in the aqueous coat is subsequently crosslinked by being exposed to laser light to produce structurally stable microcapsules of controllable thickness of the order of tens of microns. Encapsulated islets are removed from the encapsulation chamber by a valveless pump and recovered by filtration or centrifugation.03-19-2009
20110117635Multipurpose Micro Electric Field Network Cell Processing Device - A multipurpose micro electric field network cell processing device comprises: a hollow frame structure; transparent film layers which are respectively correspondingly arranged on the upper side surface and the lower side surface of the frame; electrode groups which are arranged on the transparent film layer on at least one side and used for generating a low strength electric field; wire connecting terminals of the electrode groups arranged on at least one end of the frame; and an inlet and an outlet of culture/processing solution arranged at two corresponding ends of the frame, wherein sandwich space surrounded by the two transparent film layers and the frame constitutes a cell culture/processing chamber. The device can effectively introduce or deliver a drug into target cells under a low strength electric field network environment, monitor and control the whole experiment/processing process more precisely and be conducive to separation and selection of the target cells.05-19-2011
20110117634FLAT CELL CARRIERS WITH CELL TRAPS - Cell carrier structures using dynamic flow of cell bearing, washing, or nourishing fluid, from an input reservoir region to an output reservoir region. A common feature of the several structures by which this can be achieved is the presence of channels generally having low height or other cross section, such that the cell bearing fluid readily traverses these channels by capillary action. Optional pumping assistance can also be provided. The capture wells or traps are disposed generally along the length of these channels such that the cells have multiple chances of being captured in a trap or well. The traps or wells are structured such that only a single cell can be trapped in each well or trap, and the disposition of the wells or traps as appendages to the fluid flow channels facilitates the washing or nourishing of the cells while their proliferation or development is being observed.05-19-2011
20110212509Device For And Method Of Extracting A Fraction From A Biological Sample - A device and method are provided for facilitating extraction of a fraction from a biological sample. The biological sample includes non-desired material and a fraction-bound solid phase substrate. The device includes an input zone for receiving the biological sample therein and a phase-gate zone for receiving an isolation buffer therein. An output zone receives a reagent therein. A force is movable between a first position adjacent the input zone and a second position adjacent the output zone. The force urges the fraction-bound solid phase substrate from the input zone, through the phase-gate zone and into the output zone.09-01-2011
20100068793DEVICES AND METHODS FOR PRODUCTION OF CELL AGGREGATES - A microwell device comprises a fluid vessel having a bottom region. A microwell plate is at the bottom region. The microwell plate comprises an upper region defining an upper plane. A plurality of microwells extend downwardly from the upper plane. Each of the microwells comprises an axis extending perpendicularly to the upper plane. Each of the microwells comprises a sidewall. The sidewall of at least one of the microwells has at least one wall component extending inwardly towards the axis.03-18-2010
20110104793DEVICE FOR APPLYING ELECTROMAGNETIC ENERGY TO A REACTIVE MEDIUM - The invention relates to a device (05-05-2011
20100136668SYSTEMS AND METHODS FOR ISOLATING AND USING CLINICALLY SAFE ADIPOSE DERIVED REGENERATIVE CELLS - Systems and methods are described that are used to separate cells from a wide variety of tissues. In particular, automated systems and methods are described that separate regenerative cells, e.g., stem and/or progenitor cells, from adipose tissue. The systems and methods described herein provide rapid and reliable methods of separating and concentrating regenerative cells suitable for re-infusion into a subject.06-03-2010
20080213872Disposable and Removable Nucleic Acid Extraction and Purification Cartridges For Automated Flow-Through Systems - Removable cartridges are used on automated flow-through systems for the purpose of extracting and purifying genetic material from complex matrices. Different types of cartridges are paired with specific automated protocols to concentrate, extract, and purifying pathogenic or human genetic material. Their flow-through nature allows large quantities sample to be processed. Matrices may be filtered using size exclusion and/or affinity filters to concentrate the pathogen of interest. Lysed material is ultimately passed through a filter to remove the insoluble material before the soluble genetic material is delivered past a silica-like membrane that binds the genetic material, where it is washed, dried, and eluted. Cartridges are inserted into the housing areas of flow-through automated instruments, which are equipped with sensors to ensure proper placement and usage of the cartridges. Properly inserted cartridges create fluid- and air-tight seals with the flow lines of an automated instrument.09-04-2008
20110027871Apparatus for Demineralizing Osteoinductive Bone - The invention is directed to an apparatus for producing demineralized osteoinductive bone. The apparatus demineralizes bone by subjecting bone, including, for example, ground bone, bone cubes, chips, strips, or essentially intact bone, to either a rapid high volume pulsatile acidification wave process or to a rapid continuous acid demineralization process. The pulsatile acidification wave process includes subjecting bone to two or more rapid pulse/drain cycles in which one or more demineralizing acids is rapidly pulsed into a vessel containing bone, and after a desired period of time, is rapidly drained from the vessel. The continuous acid demineralization process includes subjecting bone to a continuous exchange of demineralizing acid solution in which the demineralizing acid solution is recirculated from the container holding the bone through an ion exchange media. Calcium and phosphate are thereby removed from the bone to produce a regenerated acid, and the regenerated acid is returned to the container holding the bone. Both processes allow bone to be rapidly demineralized to a precise and specific desired residual calcium level without sacrificing osteoinductivity.02-03-2011
20110136214DUST ARRESTER AND METHOD FOR REMOVING DUST PARTICLES FROM AIR - A dust arrester includes a housing with air inlet and air outlet, wherein the ambient air containing dust particles can be introduced into the housing via the air inlet and discharged from the housing via the air outlet. The dust arrester further includes a water trough placed in the bottom of the housing and a chaos effect generator including a nozzle and a material. The nozzle can spray water supplied from the water trough. The water sprayed interacts with the material to generate a chaos condition, so that the dust particles can be removed from the introduced air under the chaos condition.06-09-2011
20100330659Tissue Processing Apparatus - An apparatus (12-30-2010
20110117633STRIPPING ABSORPTION MODULE - In a process, a portion of a liquid mixture flow is vaporized to produce a vapor and a depleted flow of liquid. The vapor is introduced to a brine which is adapted to exothermically absorb one or more components therefrom, and heat is withdrawn, to produce at least a flow of heat and a flow of brine which is enriched in the one or more components. The heat previously withdrawn is transferred, to drive the vaporization. This transfer can be associated with the change of a working fluid from a gaseous into a liquid state. In this case, the heat withdrawal involves the change of the working fluid from the liquid to the gaseous state. In the liquid state, the working fluid flows only by one or more of gravity, convection and wicking. In the gaseous state, the working fluid flows only by one or more of diffusion and convection.05-19-2011
20110189761METHOD FOR PRODUCING CELL CULTURE SCAFFOLD - To provide a simple method for producing a cell culture scaffold material having a nanoporous surface in which the pore density, pore diameter and pore diameter distribution are easily controlled.08-04-2011
20110263005PIPETTE TIP FOR ELECTROPORATION DEVICE - Provided herein is a pipette tip (10-27-2011
20100028978IN SITU HEAT INDUCED ANTIGEN RECOVERY AND STAINING APPARATUS AND METHOD - An automated microscope slide staining system and staining apparatus and method that features a plurality of individually operable miniaturized pressurizable reaction compartments or a pressurizable common chamber for individually and independently processing a plurality of microscope slides. The apparatus preferably features independently movable slide support elements each having an individually operable heating element.02-04-2010
20120040444METHOD AND APPARATUS FOR PREPARING CELLS FOR MICROTOME SECTIONING AND ARCHIVING NUCLEIC ACIDS AND PROTEINS - A method and apparatus for embedding cells that utilizes a flow-through embedding technique. The apparatus includes a cell flow pathway defined by an inflow tube for delivering cell fragments from a cell sample to a sample port. The sample port is in fluid communication with a tissue cassette having attached thereto a filter. The cell flow pathway is in communication with a reagent flow pathway for delivering the reagents through the sample port to the cassette. The apparatus is configured such that the application of pressure directs the cell fragments from the cell sample through the cell flow pathway, and effects delivery of the reagents through the reagent flow pathway. The apparatus produces an embedded cell block having concentrated cells near the plane of the block to be sectioned in a quick and efficient manner.02-16-2012
20110076754DEVICE AND METHOD FOR FILTERING ONE OR MORE PARTICLES TO BE DETECTED FROM A FLUID - A device is disclosed for filtering a particle to be detected from a fluid. In at least one embodiment, the device includes a substrate and, applied above it, a protective layer, a channel being disposed between them for the purpose of receiving a fluid containing different particles. In at least one embodiment, the channel extends at least partially in a spiral shape between its inlet and outlet and on its internal wall contains a coating for attracting a particle type to be filtered, which coating is applied at least on the radially outside subsection of the internal wall of the channel. Owing to the laminar longitudinal movement of the fluid inside the channel a radially outward directed centrifugal force acts on the particles, with the result that per time unit more particles come into contact with the radially outside subsection of the internal wall of the channel than the radially inside subsection of the internal wall of the channel. The filter effect is reinforced as a result.03-31-2011
20120045823Method and Apparatus for Collecting Biological Materials - A method and apparatus can separate and concentrate a selected component from a multi-component material. The multi-component material may include a whole sample such as adipose tissue, whole blood, or the like. The apparatus generally includes a moveable piston positioned within a separation container and a withdrawal tube that is operable to interact with a distal end of the collection container past the piston. Material can be withdrawn through the withdrawal tube.02-23-2012
20120003725MICROFLUIDIC CHIP FOR ANALYSIS FOR FLUID SAMPLE - Disclosed is a microfluidic chip capable of accurately and quickly detecting presence of a trace amount of a target within a fluid sample. It has a channel structure comprising a sample inlet for feeding a sample therethrough, a first reservoir for primarily storing the sample therein, a second reservoir for secondarily storing the sample therein, a first reaction portion in which a target is conjugated with a label, a second reaction portion in which the labeled target undergoes a specific reaction, such as an antigen-antibody reaction, and a delaying portion, located between the first and the second reaction portion, for decreasing a flow rate of the sample.01-05-2012
20110097787CONSTANT-TEMPERATURE EQUIPMENT - Constant-temperature equipment wherein maintenance is facilitated with the least failure, and highly reliable culturing and testing can be carried out. Mechanical and electrical structures are eliminated from the inside of a temperature-controlled chamber (04-28-2011
20120009662METHOD OF FABRICATING MICROFLUIDIC SYSTEMS - A method of fabricating a microfluidic system having microfluidic channels on a surface of a hydrophilic substrate, the method including the steps of: hydrophobizing the substrate surface; locating a mask defining the substrate surface, the mask having open areas defining the periphery of the microfluidic channels; and applying an irradiation treatment to areas of the substrate surface exposed by the open areas of the mask, said exposed areas becoming hydrophilic to therefore form said microfluidic channels.01-12-2012
20120015428METERING ROTARY NANOPUMP, METHOD OF FABRICATING SAME, AND APPLICATIONS OF SAME - In one aspect of the present invention, a pump includes a cam having a cam shaft, wherein the cam shaft has an axis, an exterior surface and M fins spaced-apart formed on the exterior surface along the axis; and at least one fluidic flow channel having an inlet and an outlet, disposed on a substrate, wherein the at least one fluidic flow channel helically surrounds the cam shaft such that when the cam shaft driven by the cam rotates, the M fins of the cam shaft compresses the at least one fluidic flow channels to produce a wave of compression that actuates a peristaltic flow of fluid therein so as to direct a desired amount of the fluid toward one of the inlet and the outlet.01-19-2012
20110076753Apparatus for Embedding Tissue Samples - A histology tissue embedding apparatus including a reservoir for an embedding medium and an outlet valve connected to the reservoir through which the embedding medium is dispensable, and including trigger means which control the operation of the outlet valve, the trigger means having a rest position in which the outlet valve is closed, wherein the rest position of the trigger means in relation to the outlet valve is adjustable.03-31-2011
20120070883HIGH TEMPERATURE HIGH PRESSURE MICROBIAL REACTOR - The high temperature/high pressure (HTHP) reactor of the present invention includes a main cylinder, a reversible piston inside the cylinder that divides the main cylinder into a pressurization chamber and a reactor chamber, a thermal jacket, a lid and an end cap. The HTHP reactor of the present invention is configured to facilitate microbial growth in the reactor chamber that provides high temperature and high pressure conditions that simulate resource reservoir conditions, wherein the resource may be an oil reservoir. The HTHP chamber of the present invention is configured to receive a fluid sample from the underground oil reservoir that has been maintained at reservoir temperature and pressure throughout sampling, transfer to transport bottle, transport to the laboratory, and inoculation into the chamber. The HTHP chamber of the present invention is also configured to allow the use of a variety of instrumentation and valves that can be customized to allow a user to monitor desired physical properties within the reaction chamber and the microbial behavior and byproducts. This information is used to create an individual treatment plan for a reservoir to maximize the resource recovery, for example during Microbiobial Enhanced Oil Recovery (MEOR).03-22-2012
20110091961Tissue Processor For Treating Tissue Samples - A tissue processor for treating tissue samples comprises a process chamber (04-21-2011
20120122197INKJET REAGENT DEPOSITION FOR BIOSENSOR MANUFACTURING - A technique for producing a biosensor includes inkjet printing a reagent onto electrodes of the biosensor. The ink has been specially formulated to allow the reagent to be printed using inkjet printing while at the same time produce commercially viable biosensor. The inkjet printing of the reagent allows for different inkjet patterns to be produced as well as facilitates quick change over between various products. For example, the technique allows the reagent and electrode to be formed on opposite sides of a substrate. In another example, the reagent can be layered such that incompatible reagents can be separated by a barrier layer. The electrodes for the biosensor can also be inkjet printed such that most of the biosensor can be produced using inkjet technology.05-17-2012
20100093065SINGLE CELL MICROINJECTION USING FLEXIBLE AND COMPLIANT FLUIDIC CHANNELS AND ELECTROOSMOTIC DOSAGE CONTROL - A microinjection device for injecting a target cell with a reagent. The microinjection device includes a flexible substrate; a target supply channel formed in the flexible substrate for receiving the target cell; a reagent supply channel formed in the flexible substrate for receiving the reagent; a suction capillary mounted within a suction channel formed in the flexible substrate, the suction capillary providing suction to the target supply channel for immobilizing the target cell within the target supply channel; an injection needle mounted within a needle channel formed in the flexible substrate, the injection needle being movable between injected and un-injected positions by deforming at least a part of the flexible substrate; and a plurality of electrodes embedded in the flexible substrate, the plurality of electrodes creating a voltage potential across the injection needle to move the reagent into the target when the injection needle is in the injected position.04-15-2010
20110183406Apparatus For Separating Tissue Cells From A Fluid - The invention relates to an apparatus for separating tissue cells from a fluid, with a collection container forming a collection space, which is connected, on one hand, with a negative pressure source and which is connected, on the other hand, with a supply line for the fluid-tissue cell mixture.07-28-2011
20110183405MODIFIED MULTIWELL PLATE FOR BIOCHEMICAL ANALYSES AND CELL CULTURE EXPERIMENTS. - The invention relates to a modified multi-well plate for biochemical analyses and cell culture experiments, which can be obtained through a method for functionalization. The method comprises the following process steps: 07-28-2011
20120231530METHODS OF CHROMOSOME DRYING AND SPREADING - The present invention provides for a method of drying and spreading chromosomes from various biological samples to yield optimal chromosomal spreading. The method requires preparing a biological sample for treatment, providing a cytogenetic chamber capable of setting predetermined conditions, pre-testing a portion of the biological sample in the cytogenetic chamber, and finally treating the remaining biological sample. The method is useful to yield metaphase chromosomes that are small and rounded, with very few overlapping or scattered chromosomes. Furthermore, the method is uses restricted ranges of temperature and relative humidity to achieve consistent chromosomal spreading. The morphologies of the chromosomes are preserved in order to execute banding techniques at 550 bands and chromosomal analysis on high-resolution chromosomes.09-13-2012
20120231529FLUID CONCENTRATOR WITH REMOVABLE CARTRIDGE - A fluid concentrator includes a main housing and a cartridge removably engaged to the main housing. The main housing includes a first end portion having a first port and a second port, an oppositely disposed second end portion and a separation chamber that extends between the first and second end portions. The second end portion has an inlet port and defines a cartridge passage that extends through the second end portion. The separation chamber is in fluid communication with the inlet port. The cartridge includes a first axial end portion that is engaged with the first end portion and an oppositely disposed second axial end portion, a portion of the second axial end portion is disposed in the cartridge passage of the second end portion of the main housing. The cartridge is adapted to filter fluid from the separation chamber.09-13-2012
20120171755FABRICATION OF HOLLOW NANONEEDLES - The present invention provides a method of fabricating a device having hollow nanoneedles which extend through a supporting membrane. The device can be used as a molecular delivery system.07-05-2012
20120214222METHOD FOR MANUFACTURING A DEVICE FOR REGENERATING BIOLOGICAL TISSUES, PARTICULARLY FOR REGENERATING TISSUES OF THE CENTRAL NERVOUS SYSTEM - A method for manufacturing a device for regenerating biological tissues, particularly for regenerating tissues of the central nervous system, and a device that can be manufactured with said method, the device comprising an outer sheath based on collagen which is substantially tubular and can be interposed between the endings of a biological tissue to be regenerated, and at least one supporting element based on collagen, which is accommodated inside the outer sheath.08-23-2012
20130171722METHOD AND APPARATUS FOR DELIVERY OF MOLECULES TO CELLS - The present invention is concerned with an apparatus for injection of a substance into a subject. The apparatus has an assembly including a plurality of elongate non-hollow micro-nanoneedles for delivering the substance into the subject, at least some of the micro-nanoneedles have a non-uniform diameter with a wider upper end and a narrower lower end and a length from 5-100 um, wherein the upper end has a diameter from 1-20 um and the lower end has a diameter from 50-400 nm, wherein the micro-nanoneedles are spaced apart with appropriate spacing therebetween such that when the micro-nanoneedles are penetrating cells in a penetration exercise each of the micro-nanoneedles may penetrate one cell only, and wherein the micro-nanoneedles are made from a relatively rigid material allowing the micro-nanoneedles to maintain rigidity during penetration and are configured to allow coating of the substance on the surface of the lower end.07-04-2013
20100009429IN SITU HEAT INDUCED ANTIGEN RECOVERY AND STAINING APPARATUS AND METHOD - An automated in situ heat induced antigen recovery and staining method and apparatus for treating a plurality of microscope slides. The process of heat induced antigen recovery and the process of staining the biological sample on the microscope slide are conducted in the same apparatus, wherein the microscope slides do not need to be physically removed from one apparatus to another. The reaction conditions for treating a slide can preferably be controlled independently, including the individualized application of reagents to each slide and the individualized treatment of each slide.01-14-2010
20100291662CONTAINER FOR THE PREPARATION, PRESERVATION AND STORAGE OF BIOLOGICAL SAMPLES USING A DRYING AGENT - The invention relates to a sample container (11-18-2010
20120190103DEVICE FOR THE TREATMENT OF BIOLOGICAL FLUID - The invention relates to a device (07-26-2012
20120264200SYSTEMS AND METHODS FOR ISOLATING AND USING CLINICALLY SAFE ADIPOSE DERIVED REGENERATIVE CELLS - Systems and methods are described that are used to separate cells from a wide variety of tissues. In particular, automated systems and methods are described that separate regenerative cells, e.g., stem and/or progenitor cells, from adipose tissue. The systems and methods described herein provide rapid and reliable methods of separating and concentrating regenerative cells suitable for re-infusion into a subject.10-18-2012
20120322138SELECTIVE CYTOPHERESIS DEVICES AND RELATED METHODS THEREOF - The present invention relates to systems and devices to treat and/or prevent inflammatory conditions within a subject and to related methods. More particularly, the invention relates to systems, devices, and related methods that sequester leukocytes and/or platelets and then inhibit their inflammatory action.12-20-2012
20110236960APPARATUS AND METHODS FOR INTEGRATED SAMPLE PREPARATION, REACTION AND DETECTION - Cartridges for the isolation of a biological sample and downstream biological assays on the sample are provided. In one embodiment, a nucleic acid sample is isolated from a biological sample and the nucleic acid sample is amplified, for example by the polymerase chain reaction. The cartridges provided herein can also be used for the isolation of non-nucleic acid samples, for example proteins, and to perform downstream reactions on the proteins, for example, binding assays. Instruments for carrying out the downstream biological assays and for detecting the results of the assays are also provided.09-29-2011
20110236959METHOD OF MANUFACTURING PLANAR BIO-TEST STRIP AND PRODUCT THEREOF - A planar bio-test strip includes a carrier plate, a conductive circuit formed on the carrier plate by evaporation, a testing electrode terminal and an electrode circuit terminal formed at front and rear ends of the conductive circuit respectively, and an enzyme reacting area coupled to a front end of the testing electrode terminal. A manufacturing method of the planar bio-test strip includes (1) using a plastic film as a carrier plate, and constructing a shadow mask by printing; (2) evaporating the carrier plate printed with the shadow mask to form a conductive electroplated layer; (3) removing a block of the conductive electroplated layer covered by the shadow mask by a physical method to expose the conductive circuit; (4) setting an enzyme in an enzyme reacting area; (5) attaching a cover film; such that the test strip can be mass produced with low costs, and enhanced quality, stability and market competiveness.09-29-2011
20100167382METHOD AND DEVICE FOR THE FORMATION OF BIOLOGICAL CELL MATERIAL - A manipulation tool is disclosed for producing cell material having multiple biological cells, which have a predefined geometrical arrangement. The tool includes a tool body, whose surface at least partially contacts the cell material, and a setting device for adjusting the tool body by a continuous expansion, so that geometrical properties of the surface change and an interior of the tool body is enlarged. The setting device is adapted to expand the tool body at an advance velocity in a range from 0.1 μm/h to 1 mm/h.07-01-2010
20080248560Method of Treatment of Tissue Processing Fluid and Apparatus Therefor - The present invention relates to the field of tissue processing, particularly, to the treatment of fluids used in tissue processing. In one embodiment the present invention provides for treating a tissue processing fluid comprising first processing fluid comprising a first processing fluid and a second contaminating fluid, by: gradually varying the pressure of the fluid from an initial pressure level to a first pressure level such that the fluid remains below a vaporizing point of the second contaminating fluid and, heating the fluid to at least a vaporizing temperature of the second contaminating fluid. In another embodiment, the present invention removes the second contaminating fluid from the fluid by varying at least one of the pressure and temperature of the fluid so as to allow the second contaminating fluid to vaporize. Alternatively, an embodiment of the present invention interleaves the step of removing with one or more tissue processing protocol steps. In a preferred embodiment, the invention relates to the treatment of infiltrating materials, particularly in their liquid form in a histological tissue sample processor capable of Xylene free operation.10-09-2008
20080220507Kit for Packaging Predetermined Volume of Substance to be Preserved by Cryogenic Vitrification - The invention concerns an assembly for packaging a volume of substance to be preserved by cryogenic vitrification characterized in that it comprises a sheathing (09-11-2008
20080220506Tissue scaffold having aligned fibrils, apparatus and method for producing the same, and artificial tissue and methods of use thereof - A tubular tissue scaffold is described which comprises a tube having a wall, wherein the wall includes biopolymer fibrils that are aligned in a helical pattern around the longitudinal axis of the tube where the pitch of the helical pattern changes with the radial position in the tube wall. The scaffold is capable of directing the morphological pattern of attached and growing cells to form a helical pattern around the tube walls. Additionally, an apparatus for producing such a tubular tissue scaffold is disclosed, the apparatus comprising a biopolymer gel dispersion feed pump that is operably connected to a tube-forming device having an exit port, where the tube-forming device is capable of producing a tube from the gel dispersion while providing an angular shear force across the wall of the tube, and a liquid bath located to receive the tubular tissue scaffold from the tube-forming device. A method for producing the tubular tissue scaffolds is also disclosed. Also, artificial tissue comprising living cells attached to a tubular tissue scaffold as described herein is disclosed. Methods for using the artificial tissue are also disclosed.09-11-2008
20110312069MICROVIAL WITH DIGITAL MEMORY FOR STORAGE OF OLIGONUCLEOTIDE SPECIFICATION DATA - An oligonucleotide microvial for an oligonucleotide dispensing apparatus, the microvial having a container for holding a volume of reagent, an integrated circuit with digital memory storing oligonucleotide data relating to specifications characterizing the oligonucleotides, and, electrical contacts for connection to a control processor in the reagent dispensing apparatus to provide the data to the control processor for download into devices supplied with the oligonucleotides.12-22-2011
20110312068DIALYSIS DEVICE FOR SEPARATING NUCLEATED CELLS IN A BIOLOGICAL SAMPLE FROM OTHER CONSTITUENTS - A dialysis device to separate nucleated cells in a biological sample from smaller constituents, the dialysis device having a first channel for receiving the biological sample, a second channel, and, a plurality of apertures, wherein, the second channel is fluidically connected to the first channel via the apertures, the apertures being smaller than the nucleated cells such that the smaller constituents flow from the first channel to the second channel and the nucleated cells in the biological sample remain in the first channel12-22-2011
20110312067DIALYSIS DEVICE FOR SEPARATING PATHOGENS FROM A BIOLOGICAL SAMPLE - A dialysis device to separate pathogens from a biological sample, the dialysis device having a first channel for receiving the biological sample, a second channel, and, a plurality of apertures, wherein, the second channel is fluidically connected to the first channel via the apertures such that the pathogens flow from the first channel to the second channel and larger constituents in the biological sample remain in the first channel.12-22-2011
20130189766NANOPARTICLE-TEXTURED SURFACES AND RELATED METHODS FOR SELECTIVE ADHESION, SENSING AND SEPARATION - Textured heterogeneous surfaces and related articles as can be used in conjunction with methods for selective sensing and/or separation.07-25-2013
20120021501Cell Separation Method And Apparatus - Disclosed herein are apparatus and methods for isolating a fraction of interest from a physiological fluid sample. A sample holder for isolating a fraction of interest from a physiological fluid sample includes a flexible compartment and a rigid exoskeleton that supports the flexible compartment. The flexible compartment may have at least one reservoir with a height to volume ratio of about 0.1 cm/mL to about 5 cm/mL. An automated device for extracting a fraction of interest from the sample includes a sample holder with a flexible compartment supported by a rigid exoskeleton, a support for the sample holder connected to one or more fluid extraction devices, and a motor for moving the extraction device relative to the sample holder. The automated device may include an optical sensor and may include a clamp for clamping the flexible compartment.01-26-2012
20120028342SLIP CHIP DEVICE AND METHODS - A device is described having a first surface having a plurality of first areas and a second surface having a plurality of second areas. The first surface and the second surface are opposed to one another and can move relative to each other from at least a first position where none of the plurality of first areas, having a first substance, are exposed to plurality of second areas, having a second substance, to a second position. When in the second position, the plurality of first and second areas, and therefore the first and second substances, are exposed to one another. The device may further include a series of ducts in communication with a plurality of first second areas to allow for a substance to be disposed in, or upon, the plurality of second areas when in the first position.02-02-2012
20120094364CONTINUOUS COUNTERCURRENT FLUIDIZED MOVING BED (FMB) AND/OR EXPANDED MOVING BED (EMB) - The composite continuous countercurrent fluidized moving bed (FMB) and/or expanded moving bed (EMB) for carrying out processes such as recovery, purification or reaction of single or multiple component/s of interest, by contacting liquid phase containing the said component/s with the solid adsorbent in continuous countercurrent mode. In this composite fluidized moving bed and/or expanded moving bed system the net movement of the solids is against the liquid flowing in upward direction through the stages/columns, and sedimenting solids from the one stage/column are continuously fed to the top of the another stage/column placed below or alongside of previous stage/column, and also operating in fluidized/expanded bed mode, wherein its countercurrent contact with up flowing liquid is carried out. The system described herein consists of number of stages/column as per requirement of the process. The sedimenting adsorbent solids from the last fluidized bed or expanded bed stage/column are taken out continuously and fed back to the top of the first stage/column, through a feed hopper to which the adsorbent solids are transported by means of pump or liquid solid ejector, or any other suitable device. The feed hopper is suitably designed and operated, so as deliver solid adsorbents to the top of the first stage/column continuously in a controlled manner. The flow of solid adsorbent through the said solid downcomer tube/s is controlled using valves appropriate to afford control over the downward adsorbent flow. The FMB/EMB system can be used in processes for continuous recovery, purifications or reactions of various products.04-19-2012

Patent applications in class APPARATUS

Patent applications in all subclasses APPARATUS