Class / Patent application number | Description | Number of patent applications / Date published |
435398000 | Support is a fiber | 36 |
20080299657 | ALIGNED NANOFIBERS AND RELATED METHODS OF USE - The present invention relates to nanofibers. In particular, the present invention provides aligned nanofiber bundle assemblies. In some embodiments, the aligned nanofiber bundle assemblies are used for tissue regeneration, controlled growth of cells, and related methods (e.g., diagnostic methods, research methods, drug screening). | 12-04-2008 |
20090035858 | Tissue engineering support - Cell cultures or tissue engineering supports, include at least a porous matrix based on a collagen sponge which defines first pores and a porous three-dimensional knit which defines second pores, the porous matrix filling the three-dimensional knit and all the first and second pores being at least partially interconnected with one another. | 02-05-2009 |
20090075382 | FIBRE-REINFORCED SCAFFOLD - The invention provides a fibre-reinforced scaffold for tissue engineering. The scaffold comprises a matrix comprising a biocompatible polymer, the matrix having a, porous structure; and discrete, macroscopic fibres embedded within the matrix, wherein the fibres are oriented such that at least one mechanical property of the scaffold is anisotropic. The invention further relates to fibre-reinforced films and to processes for producing such scaffolds and films. | 03-19-2009 |
20090137043 | METHODS FOR MODIFICATION OF POLYMERS, FIBERS AND TEXTILE MEDIA - The present subject matter relates to the modification of fibers by the growth of films by the Atomic Layer Epitaxy (ALE) process, which is also commonly referred to as Atomic Layer Deposition (ALD). The presently disclosed subject matter relates in particular to a process for the modification of the surface and bulk properties of fiber and textile media, including synthetic polymeric and natural fibers and yarns in woven, knit, and nonwoven form by low-temperature ALD. | 05-28-2009 |
20090148947 | FLAT MICROFIBERS AS MATRICES FOR CELL GROWTH - The present invention relates to culturing cells utilizing a matrix of microfibrillated thermoplastic polymeric materials. More specifically, the present invention relates to a method of culturing cells. In addition, the invention relates to a microfibrillated article for culturing cells dispersed in a cell culture medium. The matrix of thermoplastic polymeric materials for culturing cells of this invention finds use in tissue engineering and wound healing applications. | 06-11-2009 |
20110183419 | SILICA SOL MATERIAL FOR PRODUCING BILOGICALLY DEGRADABLE AND/OR RESORBABLE SILICA GEL MATERIALS, THE PRODUCTION AND USE THEREOF - The invention concerns a novel silica sol material and its use for producing bioabsorbable and biodegradable silica gel materials having improved properties. The materials such as for example fibres, fibrous nonwoven webs, powders, monoliths and/or coatings are used, for example, in medical technology and/or human medicine, in particular for wound treatment. | 07-28-2011 |
20110189773 | SILK FIBROIN FIBER BUNDLES FOR MATRICES IN TISSUE ENGINEERING - The present invention provides a novel silk-fiber-based matrix having a wire-rope geometry for use in producing a ligament or tendon, particularly an anterior cruciate ligament, ex vivo for implantation into a recipient in need thereof. The invention further provides the novel silk-fiber-based matrix which is seeded with pluripotent cells that proliferate and differentiate on the matrix to form a ligament or tendon ex vivo. Also disclosed is a bioengineered ligament comprising the silk-fiber-based matrix seeded with pluripotent cells that proliferate and differentiate on the matrix to form the ligament or tendon. A method for producing a ligament or tendon ex vivo comprising the novel silk-fiber-based matrix is also disclosed. | 08-04-2011 |
20110250689 | Multilayer preform obtained by electro-spinning, method for producing a preform as well as use thereof - The invention relates a multilayer preform obtained by electro-spinning, which preform is suitable as a scaffold for a prosthesis, which preform comprises at least one layer of microfibres and at least one layer of nanofibres, wherein the pore size of the at least one layer of microfibres is in the range of 1-300 micrometre and in that the pore size of the at least one layer of nanofibres is in the range of 1-300 micrometre. The present invention also relates to a method of producing said preform. The present invention also relates to the use of the present preform as a substrate for growing human or animal tissue thereon. The present invention furthermore relates to a method for growing human or animal tissue on a substrate, wherein the present preform is used as the substrate. | 10-13-2011 |
20110263021 | METHOD AND DEVICE FOR INDUSTRIAL BIOLAYER CULTIVATION - A compact, high-yield, bio-reactor for use as small, medium and large-scale production unit for therapeutic proteins, proteins in general and enzymes based on controlled activity of the cells or micro organisms and the production of such as high value antibodies for pharmaceutical and/or bio-diagnostic applications. | 10-27-2011 |
20110294214 | Seeding Cells on Porous Supports - The present invention generally relates to a method for seeding cells on to a support. In particular, the method relates to a method for seeding cells onto a porous hydrophobic support. The method utilizes centrifugal forces to uniformly guide cell seeding into the support with no loss in viability. | 12-01-2011 |
20120225484 | HUMAN PLACENTAL COLLAGEN COMPOSITIONS, AND METHODS OF MAKING AND USING THE SAME - The present invention provides compositions comprising human placental telopeptide collagen, methods of preparing the compositions, methods of their use and kits comprising the compositions. The compositions, kits and methods are useful, for example, for augmenting or replacing tissue of a mammal. | 09-06-2012 |
20130023050 | METHOD FOR CULTURE OF CORNEAL ENDOTHELIAL CELLS, PROCESS FOR PRODUCTION OF CORNEAL ENDOTHELIAL CELL SHEET FOR TRANSPLANTATION PURPOSES, AND CULTURE KIT FOR CORNEAL ENDOTHELIAL CELLS - The invention provides a method of culturing a corneal endothelial cell by use of a culture medium containing an ascorbic acid derivative and the like. | 01-24-2013 |
20130045536 | CELL CULTURE SUBSTRATE AND CELL CULTURE METHOD USING SAME - The present invention provides a cell culture substrate capable of culturing cells efficiently. The cell culture substrate of the present invention includes a substrate, a plurality of fibrous protrusions formed on the substrate, and water-repellent film formed on a surface of each of the fibrous protrusions. The fibrous protrusions are intertwined with each other to form a matrix structure. According to such a cell culture substrate, when a culture solution containing a specimen is discharged to the water-repellent fibrous protrusions, cells can be cultured easily without contact, thus enabling cells to be cultured efficiently. | 02-21-2013 |
20130115698 | METHODS AND COMBINATION - A method and a combination for the cultivation of eukaryotic cells are provided, as well as a method for preparation of eukaryotic cells. The methods comprise providing a sample of eukaryotic cells to be cultured, applying said sample to a cell scaffold material; and maintaining said cell scaffold material having cells applied thereto under conditions suitable for cell culture. The combination comprises eukaryotic cells and a cell scaffold material. The cell scaffold material comprises a polymer of a spider silk protein. | 05-09-2013 |
20130302895 | CORAL-DERIVED COLLAGEN AND METHODS OF FARMING SAME - An isolated collagen fiber is disclosed, wherein a length of the fiber prior to stretching by about 15%, is identical to a length of the fiber following said stretching by about 15%. The fiber comprises a Nuclear Magnetic Resonance (NMR) spectroscopic profile as shown in FIG. | 11-14-2013 |
20130323840 | CYLINDER CHANNEL HAVING A SAWTOOTH-SHAPED CROSS SECTION, COAXIAL CHANNEL INCLUDING SAME AND METHOD FOR MANUFACTURING SAME - The present disclosure relates to a cylinder channel having a sawtooth-shaped cross section, a method for manufacturing same, a coaxial channel including same and a method for manufacturing a microfiber or a microparticle having a sawtooth-shaped cross section using same. | 12-05-2013 |
20140051169 | PRODUCT OF CROSSLINKED MATERIAL AND METHOD FOR PRODUCING THE SAME - A method for producing a nanofiber-based product includes providing a carrier material solution having a carrier material, and bringing the carrier material in contact with a collector by electrospinning. The carrier material essentially consists of a polymer being—at least after having contacted the collector—embedded in a polymer, which polymer is formed by a crosslinker of the general formula (I) | 02-20-2014 |
20140162365 | SIMULATION SYSTEM OF CARDIAC FUNCTION, SIMULATION METHOD OF CARDIAC FUNCTION, SIMULATION PROGRAM OF CARDIAC FUNCTION, AND COMPOSITE MATERIAL SHEET - A composite material sheet to support all or any part of the heart includes a lamina or a laminate of thin sheet made of a composite material which contains reinforcement fiber matrix. A value for the Young' modulus of the reinforcement fiber is as large as one hundred times or more of a value for the Young' modulus of the matrix. | 06-12-2014 |
20150056703 | FIBER SCAFFOLDS FOR ENHANCING CELL PROLIFERATION IN CELL CULTURE - A substrate for culturing cells that includes at least one fiber scaffold adapted to be contained within a disposable or non-disposable bioreactor, wherein the fiber scaffold further includes polymer fibers that have been created by electrospinning, and wherein the orientation of the fibers in the scaffold relative to one another is generally parallel, random, or both. | 02-26-2015 |
20160017278 | PROTEIN NANOFIBERS FROM SELF-ASSEMBLING PENTAMERS - A protein nanofiber comprised of self-assembling pentamers, and a method for producing the protein nanofiber, in which the protein upon which the nanofiber is based is a specific form of COMP. The proteins self-assemble via electrostatic interactions to form fibers that extend longitudinally. | 01-21-2016 |
20160024464 | METHODS AND COMBINATION COMPRISING EUKARYOTIC CELLS AND RECOMBINANT SPIDER SILK PROTEIN - A method and a combination for the cultivation of eukaryotic cells are provided, as well as a method for preparation of eukaryotic cells. The methods comprise providing a sample of eukaryotic cells to be cultured, applying said sample to a cell scaffold material; and maintaining said cell scaffold material having cells applied thereto under conditions suitable for cell culture. The combination comprises eukaryotic cells and a cell scaffold material. The cell scaffold material comprises a polymer of a spider silk protein. | 01-28-2016 |
20160040122 | NANOFIBERS - The present disclosure relates to nanofibers. In particular, the present disclosure relates to nanofibers comprising multiple layers and their uses in cell culture and tissue engineering. | 02-11-2016 |
20160152954 | FIBER SCAFFOLDS FOR ENHANCING CELL PROLIFERATION IN CELL CULTURE | 06-02-2016 |
435399000 | Fabric, mat, gauze, or fibrous coating | 9 |
20090017541 | Porous Sheet-Form Material For Cell Culture, And Bioreactor And Culturing Method Utilizing Same - The present invention provides a bioreactor having a system that can grow cells, tissue, etc. while maintaining or improving their function, and finally recover the cells as they are with good efficiency. The bioreactor has a porous sheet-form material disposed in its main body, the porous sheet-form material being formed from a nonwoven fabric, etc. having high cell affinity in order to retain cells. This porous sheet-form material has a thermosensitive polymer and a cell-adhesive substance incorporated thereinto, and the porous sheet-form material is not only cell-adhesive but also allows cells and tissue to be detached from the porous sheet-form material as they are by, for example, cooling from 37° C. to 25° C. Furthermore, in order to efficiently ensure the bioactivity or the survival of the cells, it is arranged so that circulation of a culture medium in a culturing space of the bioreactor is of a radial flow type. | 01-15-2009 |
20120040462 | NANOFIBERS, NANOFILMS AND METHODS OF MAKING/USING THEREOF - Described herein are compositions for making nanofibers and nanofilms composed of metal oxides, organic polymers, or combinations thereof. Also described herein are methods for making nanofibers and nanofilms where the fibers are formed from a solution having more than one solvent, where the solvents are immiscible. Nanofibers and nanofilms composed of metal oxides, organic polymers or combinations thereof are described. Finally, methods for using the nanofibers and nanofilms are described. | 02-16-2012 |
20120064628 | TUBULAR SCAFFOLD FOR NEURAL GROWTH - A scaffold for neurons consists of tubes sized to promote neural growth through the tubes. The tubes may be fixed to a substrate providing electrical or optical paths out from the interior of the tubes from sensors or stimulating probes at one or more locations along the length of the coaxial axons. Steering electrodes at spaces between tubes may be used to selectively promote the growth of interconnections of different axons in a one, two, or three-dimensional fashion. | 03-15-2012 |
20120122220 | METHOD AND APPARATUS FOR MAINTENANCE AND EXPANSION OF HEMOPOIETIC STEM CELLS AND/OR PROGENITOR CELLS - A method of preparing a stromal cell conditioned medium useful in expanding undifferentiated hemopoietic stem cells to increase the number of the hemopoietic stem cells is provided. The method comprising: (a) establishing a stromal cell culture in a stationary phase plug-flow bioreactor under continuous flow on a substrate in the form of a sheet, the substrate including a non-woven fibrous matrix forming a physiologically acceptable three-dimensional network of fibers, thereby expanding undifferentiated hemopoietic stem cells ; and (b) when a desired stromal cell density has been achieved, collecting medium from the stationary phase plug-flow bioreactor, thereby obtaining the stromal cell conditioned medium useful in expanding the undifferentiated hemopoietic stem cells. | 05-17-2012 |
20120264214 | BIOCOMPATIBLE POLYMERIZABLE ACRYLATE PRODUCTS AND METHODS - Sugar-acrylic monomers are synthesized to have a carbohydrate moiety linked to an acrylate group. The sugar-acrylic monomers may be polymerized to form polymers, adhesives, hydrogels, and the like. The sugar-acrylic monomers and polymers may be used in tissue engineering, adhesives and sealers, wound healing, and the like. | 10-18-2012 |
20130157367 | NANOFIBERS WITH EXCELLENT BIODEGRADABILITY AND BIOCOMPATIBILITY AND METHOD FOR PRODUCING THE SAME - The invention provides a method for producing nanofibers of an aliphatic polyester resin (a biodegradable resin) with higher productivity than heretofore achieved, for example, without the need of cumbersome steps such as drawing and with operability at normal temperature. The method for producing nanofibers according to the invention includes (1) an extrusion step of extruding an organic solvent solution (S) into filaments in an aqueous solution (W) including a surfactant (SF) and water, the organic solvent solution (S) including an aliphatic polyester resin (A | 06-20-2013 |
20130302896 | SOY-PROTEIN CONTAINING POROUS MATERIALS - Porous soy protein-based materials are provided. Also provided are tissue growth scaffolds comprising the porous soy protein-based materials. Methods for forming the porous soy protein-based materials and methods for growing tissue on the tissue growth scaffolds are also provided. The porous soy protein-based materials comprise a plurality of soy protein chains that are crosslinked in a three-dimensional structure that provides a high degree of porosity. In order to achieve highly porous structures, the soy proteins, which are globular in nature, can be partially denatured in order to facilitate crosslinking between, and entanglement of, the soy protein chains. | 11-14-2013 |
20140302606 | METHOD FOR PRODUCING AURICULAR CARTILAGE TISSUE, AND AURICULAR CARTILAGE TISSUE - The present invention aims to provide a method for producing auricular cartilage tissue having a sufficient thickness and mechanical strength, and auricular cartilage tissue produced by the method for producing auricular cartilage tissue. | 10-09-2014 |
20160096941 | NANOFIBROUS SPONGY MICROSPHERES - A nanofibrous spongy microsphere includes porous walls that define an exterior of the microsphere and that extend through an interior of the microsphere. The porous walls consist of interconnected nanofibers and spaces formed between the interconnected nanofibers. A plurality of micro-scale pores are formed throughout the interior of the microsphere. Each of the micro-scale pores i) is partially defined by the porous walls, ii) has an interpore opening that opens to an adjacent micro-scale pores, and iii) has a diameter ranging from about 1 μm to about 100 μm. A total diameter of the microsphere ranges from about 5 μm to about 1000 μm. | 04-07-2016 |
435400000 | Hollow | 4 |
20080248572 | Bioreactor Surfaces - The present invention relates to treatment of polymeric bioreactor surfaces, to promote the proliferation of adherent cells. | 10-09-2008 |
20120040463 | HOLLOW, NOTABLY MULTI-MEMBRANE FIBERS, METHOD FOR PREPARATION THEREOF BY SPINNING AND DEVICE FOR APPLYING SAID METHOD - The present invention relates to a method for preparing fibers, notably of polysaccharide or collagen, by wet spinning under coagulation, said method notably comprising: a step for extruding a coagulable macromolecular assembly solution through a normal die; at least one partial coagulation cycle comprising a coagulation step on the one hand and a step for interrupting the coagulation on the other hand; and a step for receiving, notably by winding up, the obtained hollow fiber. The invention also relates to multi-membrane hollow fibers consisting of a same macromolecular assembly which may be spun by coagulation, notably a natural or modified natural polysaccharide in the physical hydrogel or partly dehydrated state. Said fibers including at least over their length two superposed coaxial membranes separated from each other by an inter-membrane space. The invention also relates to the spinning device for applying said method. | 02-16-2012 |
20140087466 | MICRO BLOOD VESSELS AND TISSUE DUCTS - A fiber includes one or more layers of polymer surrounding a central lumen, and living animal cells disposed within the lumen and/or within at least one of the one or more layers, wherein the fiber has an outer diameter of between 5 and 8000 microns and wherein each individual layer of polymer has a thickness of between 0.1 and 250 microns. Also disclosed are model tissues including such fibers, and method of making such fibers. The fibers can serve as synthetic blood vessels, ducts, or nerves. | 03-27-2014 |
20150322408 | Micro Blood Vessels and Tissue Ducts - A fiber includes one or more layers of polymer surrounding a central lumen, and living animal cells disposed within the lumen and/or within at least one of the one or more layers, wherein the fiber has an outer diameter of between 5 and 8000 microns and wherein each individual layer of polymer has a thickness of between 0.1 and 250 microns. Also disclosed are model tissues including such fibers, and method of making such fibers. The fibers can serve as synthetic blood vessels, ducts, or nerves. | 11-12-2015 |