Entries |
Document | Title | Date |
20090029460 | NEOPLASM-SPECIFIC POLYPEPTIDES AND THEIR USES - The present invention features novel polypeptides and methods of using these polypeptides in the diagnosis detection, monitoring, and treatment of neoplasms in mammal, e.g., a human. | 01-29-2009 |
20090258419 | METHOD FOR REMOVING PRION PROTEIN - The present invention relates to a method for removing prion PrP | 10-15-2009 |
20090305403 | Isolation and Differentiation of Adult Hippocampal Arctic Squirrel Neural Stem Cells - Neuronal stem cell lines derived from the Arctic Ground Squirrel, methods related to culturing and maintaining a neuronal stem cell line derived from the Arctic Ground Squirrel and a culture media required to maintain and differentiate a neuronal stem cell line derived from the Arctic Ground Squirrel is disclosed. Antibodies specific for antigens expressed on a neuronal stem cell line derived from the Arctic Ground Squirrel, and products and methods related to the use of neuronal stem cell lines derived from the Arctic Ground Squirrel are also included. | 12-10-2009 |
20100055780 | TARGETED NUCLEOTIDE EXCHANGE WITH PROPYNYL MODIFIED OLIGONUCLEOTIDES - A method and oligonucleotides for targeted nucleotide exchange of a duplex DNA sequence, wherein the donor oligonucleotide contains at least one modified nucleotide which is a propynylated purine and/or pyrimidine having a higher binding affinity compared to naturally occurring A, C, T or G and/or binds stronger to a nucleotide in an opposite position in the first DNA sequence as compared to a naturally occurring nucleotide complementary to the nucleotide in the opposite position in the first DNA sequence. | 03-04-2010 |
20100075414 | GROWTH OF FOREIGN CELLS AFTER CONDITIONAL AND SELECTIVE DESTRUCTION OF FETAL HOST CELLS - Foreign cells can be grown in fetal non-mammalian hosts for the production of transplant organs and tissues, the development of new therapeutic agents, and the production of biological factors and drugs. Tissue-specific injury to fetal host target cells is carried without substantial injury to the maternal host or foreign cells, providing an environment in which the injured tissue can be regenerated with the foreign cells. | 03-25-2010 |
20100105132 | Human Mesenchymal stem cells and preparation thereof - The present invention provides a process of isolation, proliferation and/or maintenance of mesenchymal stem cells (MSCs). The invention further provides a culture medium for proliferation and/or maintenance of human mesenchymal stem cells in xeno-free conditions. The culture medium provided in the present invention proliferates and/or maintains mesenchymal stem cell expansion while maintaining a multipotent phenotype. | 04-29-2010 |
20100216234 | Anti-IL-12 Antibody Based Vectors, Host Cells, and Methods of Production and Uses - Antibody expression vectors and plasmids can incorporate various antibody gene portions for transcription of the antibody DNA and expression of the antibody in an appropriate host cell. The expression vectors and plasmids have restriction enzyme sites that facilitate ligation of antibody-encoding DNA into the vectors. The vectors incorporate enhancer and promoter sequences that can be varied to interact with transcription factors in the host cell and thereby control transcription of the antibody-encoding DNA. A kit can incorporate these vectors and plasmids. | 08-26-2010 |
20100221826 | INFECTIOUS cDNA CLONE OF THE MODIFIED LIVE VIRUS VACCINE STRAIN OF EQUINE ARTERITIS VIRUS - An isolated polynucleotide molecule includes a DNA sequence encoding an infectious RNA molecule encoding a modified live viral strain of an Equine arteritis virus, wherein the DNA sequence is SEQ ID NO:1 or a degenerate variant thereof. Also provided are transformed or transfected host cells including that sequence, vectors including the sequence, and isolated infectious RNA molecules encoded by the sequence. Further, a modified DNA sequence encoding an infectious RNA molecule encoding a modified live viral strain of an Equine arteritis virus is provided wherein the DNA sequence is SEQ ID NO:2 or a degenerate variant thereof, including a si lent point mutation allowing distinguishing the modified sequence from the parent and other strains of Equine arteritis virus. | 09-02-2010 |
20110171730 | Conjugates For Use In Hepatocyte Free Uptake Assays - The present invention provides methods of identifying oligomeric compounds, such as siRNA and double-stranded RNA compounds, having bioactivity in vivo, and kits. | 07-14-2011 |
20130011920 | Methods for Reducing Protein Levels in a Cell - The present invention provides a method of reducing levels of at least one target protein in a cell. The cell is contacted with a first agent and a second agent. The first agent reduces synthesis of the target protein, e.g., by reducing levels of the mRNA of the target protein or inhibits translation of the mRNA. The second agent accelerates degradation of the target protein. The first agent may contact the cell before, after or simultaneously with the second agent. The first agent and the second agent may be in separate delivery vehicles, or in a single delivery vehicle. The first agent may be an RNAi (RNA interference) molecule, such as a small interfering RNA (siRNA), a small hairpin RNA (shRNA) or a microRNA (miRNA). The second agent may be a chimeric polypeptide containing a ubiquitin ligase polypeptide and a target protein interacting domain. The ubiquitin ligase polypeptide can be an E3 ubiquitin ligase, including, but not limited to, an SCF polypeptide, a HECT polypeptide and a UBR1 polypeptide. In one embodiment, the SCF polypeptide is an F-box polypeptide. | 01-10-2013 |
20140186945 | GROWTH OF CELLS - The present invention relates to the use of certain polymers as a substrate for stem cell, such as pluripotent stem cell growth and/or culture. The present invention also relates to articles such as tissue culture materials and cell culture devices comprising at least one polymer hydrogel as described herein. | 07-03-2014 |
20140287496 | HEAT-RESISTANT NEWCASTLE DISEASE VIRUS LIVE VACCINE VECTOR SYSTEM AND USE THEREOF - A heat-resistant NDV live vaccine vector system includes a transcription plasmid, three helper plasmids, and host cells. The transcription plasmid is constructed by through cloning complete genomic cDNA of a heat-resistant NDV vaccine strain to a pBR322 vector. The three helper plasmids are constructed by cloning sequences coding nucleoprotein (NP), phosphoprotein, large polymerase protein of a heat-resistant NDV vaccine strain respectively to pcDNA3.1 vectors. A recombinant NDV artificially obtained by cotransfacting host cells with the transcription plasmid and the three helper plasmids shows heat-resistance. | 09-25-2014 |
20150337266 | METHOD FOR PRODUCING INDUCED PLURIPOTENT STEM CELLS, CARDIOMYOCYTES OR PRECURSOR CELLS THEREOF - Nuclear reprogramming substances are contacted with a somatic cell and, after culture, cell population is fractionated based on the expression of Sca-1 or EpCam and CD34. By sorting Sca-1-negative CD34-negative cells or EpCam-positive CD34-negative cells, a cell population having high possibility of iPS cell formation can be selected. On the other hand, Sca-1-positive CD34-positive cells or EpCam-negative CD34-positive cells are useful as a source of myocardial cell or a progenitor cell thereof having a low risk of tumor formation. | 11-26-2015 |
20150376259 | COMPOSITIONS AND METHODS FOR ENHANCING ODORANT RECEPTOR ACTIVITY - The present invention relates to polypeptides capable of modulating odorant receptor activation. In particular, the present invention provides polypeptides (e.g., type 3 muscarinic actetylcholine receptor M3) capable of enhancing odorant receptor activation. The present invention further provides assays for the detection of ligands specific for various odorant receptors. Additionally, the present invention provides methods of screening for polypeptide polymorphisms and mutations associated with odorant receptor activation (e.g., polymorphisms and mutations associated with muscarinic actetylcholine receptor polypeptides (e.g., M1, M2, M3, M4, M5)), as well as methods of screening for therapeutic agents, ligands, and modulators of such proteins. | 12-31-2015 |
20180023056 | Reprogramming Method for Producing Induced Pluripotent Stem Cells (iPSC) | 01-25-2018 |