| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 435201000 | Acting on alpha-1, 4-glucosidic bond, (e.g., hyaluronidase, invertase, amylase, etc. (some 3.2.1)) | 50 |
| 20110195481 | Variants And Compositions Comprising Variants With High Stability In Presence Of A Chelating Agent - The present invention relates to variants of an alpha-amylase having improved stability to chelating agents relative to its parent enzyme, compositions comprising the variants, nucleic acids encoding the variants, methods of producing the variants, and methods for using the variants. | 08-11-2011 |
| 20110195480 | PRODUCTION OF HEMAGGLUTININ-NEURAMINIDASE PROTEIN IN MICROALGAE - The present invention is directed to recombinant microalgal cells and their use in production of heterologous hemagglutinin-neuraminidase (HN) polypeptides, as well as compositions and uses thereof. | 08-11-2011 |
| 20110287516 | Alpha-Amylase Variants - The invention relates to a variant of a parent Termamyl-like alpha-amylase, comprising mutations in two, three, four, five or six regions/positions. The variants have increased stability at high temperatures (relative to the parent). The invention also relates to a DNA construct comprising a DNA sequence encoding an alpha-amylase variant of the invention, a recombinant expression vector which carries a DNA construct of the invention, a cell which is transformed with a DNA construct of the invention, the use of an alpha-amylase variant of the invention for washing and/or dishwashing, textile desizing, starch liquefaction, a detergent additive comprising an alpha-amylase variant of the invention, a manual or automatic dishwashing detergent composition comprising an alpha-amylase variant of the invention, a method for generating a variant of a parent Termamyl-like alpha-amylase, which variant exhibits increased. | 11-24-2011 |
| 20110143419 | Utilization of Pharmacological Chaperones to Improve Manufacturing and Purification of Biologics - The present invention provides methods for improving the production of recombinant proteins through the use of pharmacological chaperones for the recombinant proteins. As exemplified by the present invention, the binding of a pharmacological chaperone to a recombinant protein expressed by a cell can stabilize the protein and increase export of the protein out of the cell's endoplasmic reticulum, and increase secretion of the protein by the cell. | 06-16-2011 |
| 20090263881 | Alpha-Amylase Mutants - The invention relates to a variant of a parent Termamyl-like α-amylase, which exhibits an alteration in at least one of the following properties relative to said parent α-amylase: i) improved pH stability at a pH from 8 to 10.5; and/or ii) improved Ca | 10-22-2009 |
| 20090137022 | Extracting and purifying beta 1,4-xylanase - The invention relates to extracting and purifying an enzyme from a cell, particularly, but not exclusively, to extracting and purifying a β1,4-xylanase. | 05-28-2009 |
| 20100159563 | Preparation and use of biofilm-degrading, multiple-specificity, hydrolytic enzyme mixtures - The present invention relates to isolated structures containing degradative enzymes produced from a marine organism. The enzymes produced are based on the carbon source upon which the marine organism is growing. The enzymes are found in structures that can be isolated such that the degradative enzymes are easily harvested. | 06-24-2010 |
| 20120196348 | Large-scale production of soluble hyaluronidase - Provided are methods for preparing culture medium that contains soluble hyaluronidases. The methods employ cells that contain a plurality of active copies of nucleic acid encoding the soluble hyaluronidase and a plurality of feedings and temperature changes, whereby the encoded soluble hyaluronidase is secreted into the cell culture medium. | 08-02-2012 |
| 20110053247 | LARGE-SCALE PRODUCTION OF SOLUBLE HYALURONIDASE - Provided are methods for preparing large-scale preparations of soluble hyaluronidases. The methods employ cells that contain a plurality of active copies of nucleic acid encoding the soluble hyaluronidase and a plurality of feedings and temperature changes, whereby the encoded soluble hyaluronidase is secreted into the cell culture medium. | 03-03-2011 |
| 20080213862 | POLYPEPTIDES HAVING ALPHA-AMYLASE ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME - The present invention relates to polypeptides having alpha-amylase activity and polynucleotides having a nucleotide sequence which encodes for the polypeptides. The invention also relates to a polypeptide having carbohydrate-binding affinity and polynucleotides having a nucleotide sequence which encodes for the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid constructs as well as methods for producing and using the polypeptides. | 09-04-2008 |
| 20090280553 | METHOD FOR DESIGNING MUTATED ENZYME, METHOD FOR PREPARING THE SAME, AND MUTATED ENZYME - It is intended to provide a novel method for improving an enzyme hydrolyzing an a-1,6-glycosidic linkage. A mutated enzyme is designed by specifying one or more amino acids selected from the group shown below in an amino acid sequence of an enzyme (an enzyme to be mutated) that hydrolyzes an a-1,6-glycosidic linkage, that is, the group consisting of an amino acid corresponding to an amino acid at the 292 position, an amino acid corresponding to an amino acid at the 371 position, an amino acid corresponding to an amino acid at the 406 position, an amino acid corresponding to an amino acid at the 407 position, an amino acid corresponding to an amino acid at the 437 position, an amino acid corresponding to an amino acid at the 465 position, an amino acid corresponding to an amino acid at the 475 position, an amino acid corresponding to an amino acid at the 476 position; an amino acid corresponding to an amino acid at the 525 position, an amino acid corresponding to an amino acid at the 526 position, an amino acid corresponding to an amino acid at the 580 position and an amino acid corresponding to an amino acid at the 582 position of the amino acid represented by in SEQ ID NO: 2 (step (1)) and constructing an amino acid sequence in which the amino acid(s) specified in the step (1) is/are substituted with another amino acid or deleted based on the amino acid sequence of the enzyme to be mutated (step (2)). | 11-12-2009 |
| 20080254526 | Mutated Xylanase Gene with a Broad PH Range of Reaction and Site-Specific Mutagenesis Method Thereof - A mutated xylanase gene with a broad pH range of reaction includes a forty-first amino acid or a twenty-first amino acid generated from transforming asparagine to aspartic acid so as to form the mutated xylanase gene. A site-specific mutagenesis method includes the step of: mutating the forty-first amino acid or the twenty-first amino acid of the xylanase gene by transforming asparagine to aspartic acid so as to form the mutated xylanase gene. | 10-16-2008 |
| 20110136205 | Alpha-amylase variants with altered properties - The present invention relates to variants (mutants) of polypeptides, in particular Termamyl-like alpha-amylases, which variant has alpha-amylase activity and exhibits an alteration in at least one of the following properties relative to said parent alpha-amylase: substrate specificity, substrate binding, substrate cleavage pattern, thermal stability, pH/activity profile, pH/stability profile, stability towards oxidation, Ca2+ dependency, specific activity, in particular laundry and dish-wash applications. | 06-09-2011 |
| 20110136206 | Alpha-amylase variant with altered properties - The present invention relates to variants (mutants) of parent Termamyl-like alpha-amylases, which variant has alpha-amylase activity and exhibits altered properties relative to the parent alpha-amylase. | 06-09-2011 |
| 20110076740 | Amylases, Nucleic Acids Encoding Them and Methods for Making and Using Them - In one aspect, the invention is directed to polypeptides having an amylase activity, polynucleotides encoding the polypeptides, and methods for making and using these polynucleotides and polypeptides. The polypeptides of the invention can be used as amylases to catalyze the hydrolysis of starch into sugars. | 03-31-2011 |
| 20100209995 | Amylases, Nucleic Acids Encoding Them and Methods for Making and Using Them - In one aspect, the invention is directed to polypeptides having an amylase activity, polynucleotides encoding the polypeptides, and methods for making and using these polynucleotides and polypeptides. In one aspect, the polypeptides of the invention can be used as amylases, for example, alpha amylases, to catalyze the hydrolysis of starch into sugars. | 08-19-2010 |
| 20120171748 | Halomonas Strain WDG195-Related Alpha-Amylases, And Methods Of Use, Thereof - Compositions and methods relating to an alpha-amylase enzyme obtained from | 07-05-2012 |
| 20080299640 | Acid alpha-glucosidase and fragments thereof - Targeted acid alpha-glucosidase therapeutics that localize to the lysosome are provided. The targeted therapeutics include a therapeutic agent, GAA, and a targeting moiety that binds a receptor on an exterior surface of the cell, permitting proper subcellular localization of the targeted therapeutic upon internalization of the receptor. Nucleic acids, cells, and methods relating to the practice of the invention are also provided. | 12-04-2008 |
| 20100233783 | NOVEL METHOD FOR PROTEIN PURIFICATION - Process for purifying a recombinant protein including one or a few procedural steps only. The process combines the step of lysis of the host cell, with the purification of the protein of interest, allowing for a rapid and much more efficient process of purification. The conditions used during the purification process are those of a high temperature and a low pH, allowing for thermostable and acid-resistant recombinant proteins to be isolated from a suspension. The invention also relates to purifying recombinant proteins which are fusion proteins, wherein one part of the protein may be selected from an enamel matrix protein, such as amelogenin. | 09-16-2010 |
| 435202000 | Alpha-amylase, microbial source | 26 |
| 20080274531 | Exo-Specific Amylase Polypeptides, Nucleic Acids Encoding Those Polypeptides And Uses Thereof - This invention relates to amylase polypeptides, and nucleic acids encoding the polypeptides and uses thereof. The amylases of the present invention have been engineered to have more beneficial qualities. Specifically the amylases of the current invention show an altered exospecifity. | 11-06-2008 |
| 20090155882 | Alpha-Amylase Variants - The invention relates to a variant of a parent Termamyl-like alpha-amylase, which variant exhibits altered properties, in particular reduced capability of cleaving a substrate close to the branching point, and improved substrate specificity and/or improved specific activity relative to the parent alpha-amylase. | 06-18-2009 |
| 20090286302 | Desizing and Scouring Process - The present invention relates to processes for combined desizing and scouring of a sized fabric containing starch or starch derivatives during manufacture of fabric, which process comprises incubating said sized fabric in an aqueous treating solution having a pH in the range between 1 and 7, which aqueous treating solution comprises an acid amylase and at least one other acid enzyme facilitating said other fabric treatment steps. The present invention further relates to compositions used in said processes and the use of said compositions. | 11-19-2009 |
| 20100015686 | Variant Alpha-Amylases from Bacillus Subtilis and Methods of Uses, Thereof - Alpha-amylases from | 01-21-2010 |
| 20090117642 | ALPHA-AMYLASE VARIANTS WITH ALTERED PROPERTIES - Disclosed are compositions comprising variants of a parent | 05-07-2009 |
| 20090104681 | Polypeptides Having Alpha-Amylase and Granular Starch Hydrolyzing Activity - The present invention relates to a polypeptide having alpha-amylase activity obtained from a strain of | 04-23-2009 |
| 20110207201 | ALPHA-AMYLASE MUTANTS - The invention relates to a variant of a parent Termamyl-like alpha-amylase, which variant has alpha-amylase activity and exhibits an alteration in at least one of the following properties relative to said parent alpha-amylase: substrate specificity, substrate binding, substrate cleavage pattern, thermal stability, pH/activity profile, pH/stability profile, stability towards oxidation, Ca | 08-25-2011 |
| 20090239284 | Alkaline Bacillus Amylase - This invention relates to an amylase derived from | 09-24-2009 |
| 20120142074 | Compositions and Uses for an Alpha-Amylase Polypeptide of Bacillus Species 195 - Disclosed herein are compositions comprising an alpha-amylase enzyme obtained from | 06-07-2012 |
| 20120202265 | METHODS FOR REDUCING BLUE SACCHARIDE - The present disclosure relates to a | 08-09-2012 |
| 20110076741 | ALPHA-AMYLASE VARIANTS - The invention relates to a variant of a parent Termamyl-like alpha-amylase, which variant exhibits altered properties, in particular reduced capability of cleaving a substrate close to the branching point, and improved substrate specificity and/or improved specific activity relative to the parent alpha-amylase. | 03-31-2011 |
| 20090203107 | Thermophilic and thermoacidophilic biopolymer-degrading genes and enzymes from alicyclobacillus acidocaldarius and related organisms, methods - Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from | 08-13-2009 |
| 20090203108 | Method for preparing maltogenic alpha-amylase variants - The inventors have modified the amino acid sequence of a maltogenic alpha-amylase to obtain variants with improved properties, based on the three-dimensional structure of the maltogenic alpha-amylase Novamyl. The variants have altered physicochemical properties., e.g. an altered pH optimum, improved thermostability, increased specific activity, an altered cleavage pattern or an increased ability to reduce retrogradation of starch or staling of bread. | 08-13-2009 |
| 20090203109 | Alpha-Amylase Variants - The invention relates to a variant of a parent Termamyl-like α-amylase, comprising mutations in two, three, four, five or six regions/positions. The variants have increased stability at high temperatures (relative to the parent). The invention also relates to a DNA construct comprising a DNA sequence encoding an α-amylase variant of the invention, a recombinant expression vector which carries a DNA construct of the invention, a cell which is transformed with a DNA construct of the invention, the use of an α-amylase variant of the invention for washing and/or dishwashing, textile desizing, starch liquefaction, a detergent additive comprising an α-amylase variant of the invention, a manual or automatic dishwashing detergent composition comprising an α-amylase variant of the invention, a method for generating a variant of a parent Termamyl-like α-amylase, which variant exhibits increased. | 08-13-2009 |
| 20120021489 | MICROBIAL ENZYMES AS DETERGENT ADDITIVES - Provided in part herein are compositions that include isolated microbial enzymes, such as amylases, lipases, and proteases that are useful as detergent additives. Also provided are methods of isolating amylases, lipases, and proteases from microbes, as well as methods of using these enzymes as detergent additives, and for stain removal. | 01-26-2012 |
| 20120252095 | Alpha-Amylase Variants - The invention relates to a variant of a parent Termamyl-like alpha-amylase, comprising mutations in two, three, four, five or six regions/positions. The variants have increased stability at high temperatures (relative to the parent). The invention also relates to a DNA construct comprising a DNA sequence encoding an alpha-amylase variant of the invention, a recombinant expression vector which carries a DNA construct of the invention, a cell which is transformed with a DNA construct of the invention, the use of an alpha-amylase variant of the invention for washing and/or dishwashing, textile desizing, starch liquefaction, a detergent additive comprising an alpha-amylase variant of the invention, a manual or automatic dishwashing detergent composition comprising an alpha-amylase variant of the invention, a method for generating a variant of a parent Termamyl-like alpha-amylase, which variant exhibits increased. | 10-04-2012 |
| 20110275136 | AMYLASE VARIANTS - The present invention relates to variants (mutants) of polypeptides, in particular Termamyl-like alpha-amylases, which variant has alpha-amylase activity and exhibits an alteration in at least one of the following properties relative to said parent alpha-amylase: substrate specificity, substrate binding, substrate cleavage pattern, thermal stability, pH/activity profile, pH/stability profile, stability towards oxidation, Ca | 11-10-2011 |
| 20120282672 | Alpha-Amylase Mutants - The invention relates to a variant of a parent Termamyl-like alpha-amylase, which variant has alpha-amylase activity and exhibits an alteration in at least one of the following properties relative to the parent alpha-amylase: substrate specificity, substrate binding, substrate cleavage pattern, thermal stability, pH/activity profile, pH/stability profile, stability towards oxidation, Ca | 11-08-2012 |
| 20110159570 | Method for preparing maltogenic alpha-amylase variants - The inventors have modified the amino acid sequence of a maltogenic alpha-amylase to obtain variants with improved properties, based on the three-dimensional structure of the maltogenic alpha-amylase Novamyl. The variants have altered physicochemical properties, e.g. an altered pH optimum, improved thermostability, increased specific activity, an altered cleavage pattern or an increased ability to reduce retrogradation of starch or staling of bread. | 06-30-2011 |
| 20080227173 | Polypeptide - The invention describes a PS4 variant polypeptide derivable from a parent polypeptide having amylase activity selected from the group consisting of: (a) a polypeptide comprising an amino acid mutation at each of positions 33, 34, 121, 134, 141, 146, 157, 161, 178, 179, 223, 229, 272, 303, 307, 309 and 334; (b) a polypeptide comprising an amino acid mutation at each of positions 33, 34, 121, 134, 141, 145, 146, 157, 178, 179, 223, 229, 272, 303, 307 and 334; (c) a polypeptide comprising an amino acid mutation at each of positions 33, 34, 121, 134, 141, 146, 157, 178, 179, 223, 229, 272, 303, 307, 309 and 334; and (d) a polypeptide comprising an amino acid mutation at each of positions 3, 33, 34, 70, 121, 134, 141, 146, 157, 178, 179, 223, 229, 272, 303, 307, 309 and 334; with reference to the position numbering of a | 09-18-2008 |
| 20130149770 | Variant Alpha-Amylases from Bacillus Subtilis and Methods of Uses, Thereof - Alpha-amylases from | 06-13-2013 |
| 435203000 | Fungal source | 5 |
| 20100120119 | METHOD OF PRODUCING LIQUID KOJI - An object of the present invention is to provide a method of producing liquid koji having high enzymatic activity by optimizing composition of liquid medium for the liquid koji. In particular, the present invention provides a method of producing liquid koji having enhanced enzymatic activity, the method comprising culturing white koji molds and/or black koji molds in liquid medium containing a nitrogen source by using the cereal of which surface is entirely or partly covered with husks as culture raw material. | 05-13-2010 |
| 20100216213 | Polypeptides Having Glucoamylase Activity and Polynucleotides Encoding Same - The present invention relates to polypeptides having glucoamylase activity and isolated polynucleotides encoding said polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides. The invention also relates to the composition comprising a glucoamylase of the invention as well as the use such compositions for starch conversion processes, brewing, including processes for producing fermentation products or syrups. | 08-26-2010 |
| 20100209996 | Thermostable Alpha-Amylases - The present invention relates to an isolated polynucleotide comprising an open reading frame encoding a polypeptide having alpha-amylase activity, the polypeptide selected from the group consisting of: | 08-19-2010 |
| 20100136655 | FUNGAL ALPHA-AMYLASE VARIANTS - The inventors have developed a method of altering the amino acid sequence of a fungal alpha-amylase to obtain variants, and they have used the method to construct such variants. The variants may be useful for anti-staling in baked products. Accordingly, the invention provides a method of constructing fungal alpha-amylase variants based on a comparison of three-dimensional (3D) structures of the fungal alpha-amylase and a maltogenic alpha-amylase. One or both models includes a substrate. The invention also provides novel fungal alpha-amylase variants. | 06-03-2010 |
| 20130130353 | Variants of Glycoside Hydrolases - The present invention relates to variants of a parent glycoside hydrolase, comprising a substitution at one or more positions corresponding to positions 21, 94, 157, 205, 206, 247, 337, 350, 373, 383, 438, 455, 467, and 486 of amino acids 1 to 513 of SEQ ID NO: 2, and optionally further comprising a substitution at one or more positions corresponding to positions 8, 22, 41, 49, 57, 113, 193, 196, 226, 227, 246, 251, 255, 259, 301, 356, 371, 411, and 462 of amino acids 1 to 513 of SEQ ID NO: 2 a substitution at one or more positions corresponding to positions 8, 22, 41, 49, 57, 113, 193, 196, 226, 227, 246, 251, 255, 259, 301, 356, 371, 411, and 462 of amino acids 1 to 513 of SEQ ID NO: 2, wherein the variants have glycoside hydrolase activity. The present invention also relates to nucleotide sequences encoding the variant glycoside hydrolases and to nucleic acid constructs, vectors, and host cells comprising the nucleotide sequences. | 05-23-2013 |
| 435205000 | Glucoamylase (3.2.1.3) | 5 |
| 20110014681 | GLUCOAMYLASE VARIANTS - The present invention relates to glucoamylase variants. In particular, the invention relates to variants in the starch binding domain (SBD) of a glucoamylase. The invention also relates to variants having altered properties (e.g., improved thermostability and/or increased specific activity) as compared to a corresponding parent glucoamylase. The present invention also provides enzyme compositions comprising the variant glucoamylases; DNA constructs comprising polynucleotides encoding the variants; and methods of producing the glucoamylase variants in host cells. | 01-20-2011 |
| 20110020899 | GLUCOAMYLASE VARIANTS WITH ALTERED PROPERTIES - The present invention relates to variant glucoamylases wherein the variant has altered properties (e.g., improved thermostability and/or specific activity) compared to a corresponding parent glucoamylase. The present invention also relates to enzyme compositions comprising a variant glucoamylase (e.g., starch hydrolyzing compositions); DNA constructs comprising polynucleotides encoding the variants and methods of producing the variant glucoamylases in host cells | 01-27-2011 |
| 20120149087 | GLUCOAMYLASE VARIANTS WITH ALTERED PROPERTIES - The present disclosure relates to variants of a parent glucoamylase having altered properties (e.g., improved thermostability and/or specific activity). In particular, the present disclosure provides compositions comprising the variant glucoamylases, including starch hydrolyzing compositions and cleaning compositions. The disclosure also relates to DNA constructs encoding the variants and methods of producing the glucoamylase variants in host cells. | 06-14-2012 |
| 20130122570 | Glucoamylase Variants - The invention relates to a variant of a parent fungal glucoamylase, which exhibits improved thermal stability and/or increased specific activity using saccharide substrates. | 05-16-2013 |
| 20130122569 | Expression of Granular Starch Hydrolyzing Enzymes in Trichoderma and Process for Producing Glucose from Granular Starch Sustrates - The present invention relates to filamentous fungal host cells and particularly | 05-16-2013 |
