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Enzyme or microbial cell is immobilized on or in an organic carrier

Subclass of:

435 - Chemistry: molecular biology and microbiology


Patent class list (only not empty are listed)

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Class / Patent application numberDescriptionNumber of patent applications / Date published
435180000 Carrier is synthetic polymer 61
435178000 Carrier is carbohydrate 25
20130045521SYSTEM AND METHOD FOR SUPPORTING A BIOLOGICAL CHIP DEVICE - A support apparatus for maintaining, storing, and transporting biological materials, such as cells. In accordance with certain embodiments of the invention, the biologic materials may be integrated, to an electronic component to form a biological chip device, which may be supported, transported, and adapted for interconnection with other such, devices through, the use of a support apparatus in accordance with embodiments of the invention. In certain embodiments, the support apparatus can generate signals and/or translate signals received for processing and/or relaying to another device or module (e.g., another support apparatus). A plurality of biological chip devices and associated support apparatuses can be supported and linked in a network to perform various desired functions.02-21-2013
20100081186Self-decontaminating metal organic frameworks - A self-decontaminating metal organic framework including an acid linked to a metal producing a metal organic framework configured for the sorption of chemical warfare agents and/or toxic industrial chemicals, the metal organic framework including reactive sites for the degradation of the agents and chemicals.04-01-2010
20090011485METHOD OF RETROVIRUS STORAGE - A method of retrovirus storage, characterized in that a retrovirus is sustained in the presence of a substance with retrovirus binding activity immobilized on a solid phase. Further, there is provided a retrovirus composition characterized in that a retrovirus in the form of binding to a substance with retrovirus binding activity is sealed in a container holding a solid phase having the substance with retrovirus binding activity immobilized thereon.01-08-2009
20120003711DEVICE FOR CAPTURING CIRCULATING CELLS - The present invention provides devices and methods for capturing rare cells. The devices and methods described herein can be used to facilitate the diagnosis and monitoring of metastatic cancers.01-05-2012
20110294187CAPTURING PARTICLES - Methods and systems capturing particles suspended in a fluid flowed through a micro-channel, can include flowing the fluid including the particles to be captured through a micro-channel and past a groove defined in a surface of a wall of the micro-channel such that flowing the fluid past the groove forms microvortices in the fluid; contacting at least some of the particles against an adherent disposed on one or more of walls of the microchannel after the microvortices form in the fluid; and capturing at least some of the particles contacting the adherent.12-01-2011
20110294186DEVICES AND METHODS FOR ENRICHMENT AND ALTERATION OF CIRCULATING TUMOR CELLS AND OTHER PARTICLES - The invention features devices and methods for detecting, enriching, and analyzing circulating tumor cells and other particles. The invention further features methods of diagnosing a condition, e.g., cancer, in a subject by analyzing a cellular sample from the subject.12-01-2011
20100124776ALLOGRAFTS COMBINED WITH TISSUE DERIVED STEM CELLS FOR BONE HEALING - There is disclosed a method of combining mesenchymal stem cells (MSCs) with a bone substrate. In an embodiment, the method includes obtaining tissue having MSCs together with unwanted cells. The tissue is digested to form a cell suspension having MSCs and unwanted cells. The cell suspension is added to the substrate. The substrate is cultured to allow the MSCs to adhere. The substrate is rinsed to remove unwanted cells. In various embodiments, the tissue is adipose issue, muscle tissue, or bone marrow tissue. In an embodiment, there is disclosed an allograft product including a combination of MSCs with a bone substrate in which the combination is manufactured by culturing MSCs disposed on the substrate for a period of time to allow the MSCs to adhere to the substrate, and then rinsing the substrate to remove unwanted cells from the substrate. Other embodiments are also disclosed.05-20-2010
20100120115Compositions and Methods for Making and Using Laminin Nanofibers - The present invention encompasses methodologies and parameters for the formation of nanofibrous (to microfibrous) laminin via electrospinning. The present application discloses conditions and appropriate parameters to synthesize laminin fibers from a diameter of about 10 nM to a diameter of over 1,000 nM via electrospinning.05-13-2010
20110269207CELL AND BIOFACTOR PRINTABLE BIOPAPERS - Disclosed herein is a structure having: a porous polymeric film permeated by a first extracellular matrix material; and a topcoat layer comprising a second extracellular matrix gel disposed on the film. Also disclosed herein is a method of: providing a porous polymeric film; permeating the film with a first extracellular matrix material; and applying a topcoat layer of a second extracellular matrix material to the film. Also disclosed herein is a method of: laser-machining holes through a film comprising collagen to form a web-like structure.11-03-2011
20090081753METHOD FOR FORMULATING AND IMMOBILIZING A MATRIX PROTEIN AND A MATRIX PROTEIN FOR USE IN A SENSOR - A method for formulating and immobilizing a protein and a protein matrix formed by the method. The protein matrix preparation method results in a physically and chemically stable protein matrix that has low swelling, non-leaching, high activity, and high mechanical strength properties. The method includes cross-linking and hardening the protein mixture and using a mold to form a protein into a desired shape and size.03-26-2009
20090239282Method of storing and/or transporting in vitro cell cultures - The invention relates to a method of storing and/or transporting in vitro two-dimensional cell cultures. The inventive method comprises the following steps consisting in: a) coating a cell culture that is immobilised on an asymmetric support with a gelatine solution in culture medium at a concentration of between 1 and 5%; b) solidifying the gelatine added to the support at a temperature of between 15 and 25° C.; and c) storing and/or transporting the cell culture at a temperature of between 15 and 25° C. for a period of up to 96 hours. The invention also relates to a kit which is used to store and/or transport the in vitro two-dimensional cell cultures according to the inventive method, said kit comprising: i) an asymmetric support, and (ii) a gelatine solution in culture medium at a concentration of between 1 and 5%.09-24-2009
20100311143ENZYME ELECTRODE AND METHOD FOR PRODUCING THE SAME - The present invention discloses an enzyme electrode and its producing method, which comprises: providing a substrate with a carbon surface; forming a gold surface on the carbon surface and thus forming an electrode; covalently bonding a mediator containing an aldehyde group to the electrode; and covalently bonding a glucose oxidase to the electrode.12-09-2010
20110129893MONITORING TARGET ENDOGENOUS SPECIES - An electrode comprising: a conducting substrate for detecting an electroactive agent; a catalytic agent held on the substrate for converting a non-electroactive agent to an electroactive agent by a catalytic process which consumes oxygen; and an oxygen reservoir, for releasing oxygen to feed the catalytic process, held within a polymer matrix on the substrate. The electrode allows for detection of materials such as glucose when using oxidase enzymes. The invention solves the problem of fluctuation or depletion of oxygen in the environment in which the measurements are being taken.06-02-2011
20100068783TAILORED CONTROL OF SURFACE PROPERTIES BY CHEMICAL MODIFICATION - A process for producing a substrate having an adhesive surface, which process comprises: (a) contacting the substrate with a carbene precursor, which carbene precursor is a compound of the following formula (1): whose substituent groups are SP defined herein, provided that when R is aryl or heteroaryl, said aryl or heteroaryl may be substituted by one, two, three, four or five groups, which groups are independently selected from various groups including -L03-18-2010
20110081701SURGICAL COMPOSITIONS - The present disclosure relates to methods of cell encapsulation using multi-component hydrogels. The hydrogels may include a natural component having nucleophilic functional groups as well as an electrophilic component. In embodiments, at least one of the components may be branched, having drugs, antibodies, enzymes, and the like incorporated therein, which may react with at least one of the other components of the hydrogel.04-07-2011
20120034670ORGANIC-INORGANIC COMPOSITE MATERIAL AND PROCESS FOR PRODUCING SAME - Disclosed is an organic-inorganic composite material obtained by chemically modifying a microorganism-derived ceramic material with an organic group, and a process for producing the organic-inorganic composite material. The process is characterized by reacting a microorganism-derived ceramic material with at least one compound selected from the group consisting of silane coupling agents represented by formula (1), silane coupling agents represented by formula (2), and titanate coupling agents represented by formula (3). The organic-inorganic complex can be used in applications for immobilized catalysts and immobilized enzyme catalysts.02-09-2012
20100261244METHOD FOR IMMOBILIZING BIO-MATERIAL ON TITANIUM DIOXIDE NANOPARTICLES AND TITANIUM DIOXIDE NANOPARTICLES IMMOBILIZED BY BIO-MATERIAL - There is provided a method for immobilizing a bio-material on a surface of titanium dioxide nanoparticles (TiO10-14-2010
20100003735Mild Chemically Cleavable Linker System - A linker system is provided where a small molecule reactive group, e.g., an activity based probe which binds to certain enzymes at the active site, is linked through an aryl diazo linker to an affinity molecule such as biotin. The reactive group may comprise a number of functionalities known to react with a specific target to be studied. This enables the probe to be exposed to analytes, such as proteins and bind specifically to them to form a complex having an affinity molecule allowing immobilization of the bound analyte on an affinity column or other support, e.g. with streptavidin. Then, the linker is cleaved without causing removal of the affinity group or dissociation of the probe from the analyte. The linker is cleaved under mild reducing conditions, e.g., dithionite. The probe is synthesized along with the linker on a solid support.01-07-2010
20080293118Magnetic fine particles having lower critical solution temperature - The present invention relates to magnetic fine particles having a lower critical solution temperature to which at least one substance selected from biotin and avidin is immobilized, and a method of converting a substance, a method of separating or concentrating a microorganism, a method of modifying a denatured protein, a method of detecting a nucleic acid, a separating agent, and a method of separating a biological substance using the same.11-27-2008
20090286300MICROFLUIDIC SYSTEM AND METHOD FOR SORTING CELL CLUSTERS AND FOR THE CONTINUOUS ENCAPSULATION THEREOF FOLLOWING SORTING THEREOF - A microfluidic system and method for sorting cell clusters, and for the continuous and automated encapsulation of the clusters, once sorted, in capsules of sizes suitable for those of these sorted clusters is provided. The microfluidic system comprises a substrate in which a microchannel array comprising a cell sorting unit is etched and around which a protective cover is bonded, and the sorting unit comprises deflection means capable of separating, during the flow thereof, relatively noncohesive cell clusters, each of size ranging from 20 μm to 500 μm and of 20 to 10 000 cells approximately, such as islets of Langerhans, at least two sorting microchannels arranged in parallel at the outlet of said unit being respectively designed so as to transport as many categories of sorted clusters continuously to a unit for encapsulation of the latter, also formed in said array.11-19-2009
20110076736FUEL CELL, METHOD FOR MANUFACTURING FUEL CELL, ELECTRONIC APPARATUS, ENZYME IMMOBILIZATION ELECTRODE, BIOSENSOR, BIOREACTOR, ENERGY CONVERSION ELEMENT, AND ENZYME REACTION-UTILIZING APPARATUS - A fuel cell and a method for manufacturing the same are provided, wherein at least one type of enzyme and coenzyme are confined in a minute space, an enzyme reaction is effected while this space serves as a reaction field. Thereby, electrons can be taken out of the fuel efficiently to generate electrical energy, and immobilization of these enzyme and coenzyme on an electrode can be performed easily. The enzyme and the coenzyme required for an enzyme reaction are encapsulated in a liposome, and the resulting liposome is immobilized on the surface of an electrode formed from porous carbon or the like so as to form an enzyme immobilization electrode. A transporter is incorporated in the liposome, as necessary. An electron mediator is also immobilized on the surface of the electrode. The resulting enzyme immobilization electrode is used as, for example, a negative electrode of a biofuel cell.03-31-2011
20110091956BIOMOLECULE-IMMOBILIZED CARRIER AND METHOD FOR IMMOBILIZING BIOMOLECULE ON CARRIER - Provided are a biomolecule-immobilized carrier obtained by immobilizing a biomolecule having a membrane-binding peptide containing a C terminal polypeptide of fucosyltransferase derived from 04-21-2011
20100209988Bioremediation Materials - Microbially colonised charred biological material, such as charcoal, wherein the colonising microbes are capable of metabolising at least one selected environmental substance, such as a pollutant, and wherein a selective amount of the substance is present in the charred material provide protected colonies of environmentally active microbes useful in bioremediation, for example.08-19-2010
20100184183COLLAGEN SCAFFOLD MODIFIED BY COVALENT GRAFTING OF ADHESION MOLECULES, ASSOCIATED METHODS AND USE THEREOF FOR CARDIOVASCULAR AND THORACIC CELL THERAPY AND CONTRACTILE TISSUE ENGINEERING - Materials and methods for improving the biological properties and electromechanical performance of collagen scaffolds used for cell transplantation, including the fixation of biocompatible reagents and adhesion molecules which control cell adhesion, apoptosis, survival and/or differentiation simultaneously. The grafting of adhesion molecules to collagen matrices renders same suitable for use in vascular and cardiothoracic surgery/medicine, as well as in cell therapy for the heart and in artificial heart muscle engineering. Also, a simple method for grafting and optimising the presentation of adhesion peptides or biological agents when the scaffold is made from collagen and/or contains accessible thiol, amine or carboxyl groups.07-22-2010
20120252089CYTOCOMPATIBLE ALGINATE GELS - The present invention relates to a method of making cytocompatible alginate gels and their use in the treatment of cardiomyopathy.10-04-2012
20100273231Multipotent mesenchymal stem cells from human hair follicles - The present invention is directed to an enriched preparation of multipotent mesenchymal cells obtained from human hair follicle stem cells, preferably adult human hair follicle cells. These cells can be differentiated into adipogenic, chondrogenic and osteogenic cells as well as smooth muscle cells. The present invention is also directed to a method of producing a tissue-engineered vascular vessel containing the preparation of isolated smooth muscle cells or progenitors thereof. The resulting tissue-engineered vascular vessel and a method of producing a tissue-engineered vascular vessel for a particular patient are also disclosed.10-28-2010
20080299637Production of Conjugates - A method of reacting a first chemical entity and a second chemical entity to form a conjugate in which the first and second chemical entities are covalently bound with respect to each other, comprises bringing into simultaneous contact the first chemical entity, the second chemical entity and a thiol generator, wherein the thiol generator reacts with the first chemical entity in a thiolation reaction resulting in formation of a free sulfhydryl group on the first chemical entity, and the free sulfhydryl group reacts with the second chemical entity to form the conjugate, and wherein the second chemical entity is polyvalent with respect to its reactivity with sulfhydryl groups. The present invention primarily differs from the prior art in that no separation step is involved between reaction of the thiol generator and first chemical entity and reaction with the second chemical entity. The invention also provides a conjugation kit.12-04-2008
20080213858Stabilization of Enzymes - A process for producing enzymes structures includes providing an emulsion of droplets of a first liquid phase dispersed in a second liquid phase. The one liquid phase is a hydrophilic phase, while the other liquid phase is a hydrophobic phase which is immiscible with the hydrophilic phase. Enzyme molecules are located at or within interfacial boundaries of the droplets and the second liquid phase. The enzyme molecules of the respective droplets are cross-linked so that individual enzyme structures, which are stable and in which the enzymes are immobilized with a majority of active sites of the enzymes being orientated either internally or externally, are formed from individual droplets.09-04-2008
20130171712CULTURE METHOD AND CULTURE DEVICE - Provided are a culture method and a culture device for efficiently producing cells and/or cell tissue suitable for medication applications. A culture method of culturing cells adhered onto an electrode layer, the method including: a first step of adhering the cells onto the electrode layer and culturing the cells thereon, the electrode layer being coated with an oligopeptide including: a terminal amino acid; a cell adhesive sequence; and an alternating sequence to be bound to the one end side of the cell-adhesive sequence, the alternating sequence including a plurality of acidic amino acids and a plurality of basic amino acids, being alternately bound to each other one by one; and a second step of applying, to the electrode layer having the cells adhered thereonto, an electrical potential inducing reductive desorption of the oligopeptide, to thereby detach the cells from the electrode layer.07-04-2013
20130102048METHOD OF RETROVIRUS STORAGE - A method of retrovirus storage, characterized in that a retrovirus is sustained in the presence of a substance with retrovirus binding activity immobilized on a solid phase. Further, there is provided a retrovirus composition characterized in that a retrovirus in the form of binding to a substance with retrovirus binding activity is sealed in a container holding a solid phase having the substance with retrovirus binding activity immobilized thereon.04-25-2013
20130203146MICROFABRICATED SCAFFOLD STRUCTURES - The present invention relates to a method for producing a three-dimensional scaffold construct comprising encapsulated cells, the method comprising: (a) providing a solution comprising cells, a photoinitiator, and a plurality of units capable of forming polymer chains; (b) providing a photolithography instrument comprising a two-photon laser; and (c) using the instrument to apply the laser to the solution to activate the photoinitiator thereby facilitating polymerisation of said units to form polymer chains, and, cross-linking of the polymer chains; wherein the laser is applied to the solution in three-dimensions in a pre-defined pattern to assemble said construct, and said cells are encapsulated within the assembled construct.08-08-2013

Patent applications in class Enzyme or microbial cell is immobilized on or in an organic carrier

Patent applications in all subclasses Enzyme or microbial cell is immobilized on or in an organic carrier