Entries |
Document | Title | Date |
20080199931 | POLYNUCLEOTIDE ENCODING AN INTRACELLULAR ESTRADIOL BINDING PROTEIN - Described herein is a novel intracellular estradiol binding protein (“IEBP”), as well as a polynucleotide encoding this protein and various cells and cell lines producing and/or overexpressing it. IEBP is believed to play a role in the modulation of estrogen signaling and in the physiological resistance to the same. Abnormally elevated or decreased levels of IEBP may thus be a component of the etiology of diseases generally correlated with estrogen signaling, such as, by way of example, breast cancer and osteoporosis. Various embodiments of the present invention are believed to provide important tools for developing treatments for these conditions, such as, for example, by providing means for screening therapeutic compounds and identifying a genetic target for therapy. | 08-21-2008 |
20080206829 | EPOXY ENHANCED POLYMER MEMBRANE TO INCREASE DURABILITY OF BIOSENSORS - The present invention provides a polymer membrane enhanced with cured epoxy resin for use as the outer membrane of biosensors. The membrane includes approximately 30-80% epoxy resin adhesives, 10-60% polymer such as poly(vinyl chloride), polycarbonate and polyurethane and 0-30% plasticizers and 5-15% surface modifier reagent such as polyethylene oxide-containing block copolymers. Utilizing the polymer membrane of the present invention, a three-layered sensing element has been developed. This sensing element will be particularly useful for miniaturized biosensors used for in vitro blood measurements or for continuous in vivo monitoring such as implantable biosensors. This element includes an enzyme layer, an interference-eliminating layer and the novel polymer member of the present invention as the outer polymer layer. This novel sensing element shows excellent response characteristics in solutions and has an extremely long lifetime. This technology is particularly useful for improving the lifetime of implantable biosensors. | 08-28-2008 |
20080206830 | GRANULE WITH HYDRATED BARRIER MATERIAL - A granule having high stability and low dust is described. The granule includes a hydrated barrier material having moderate or high water activity. Also described are methods of producing the granules. | 08-28-2008 |
20080220495 | DELTA3, FTHMA-070, TANGO85, TANGO77, SPOIL, NEOKINE, TANGO129 and integrin alpha subunit protein and nucleic acid molecules and uses thereof - The invention provides novel Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 polypeptides, proteins, and nucleic acid molecules. In addition to isolated, full-length Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 proteins, the invention further provides isolated Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 fusion proteins, antigenic peptides and anti-Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 antibodies. The invention also provides Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 or A259 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided. | 09-11-2008 |
20080220496 | Catalase decomposition of hydrogen peroxide in surfactants - A process comprising the steps of continuously adding a catalase enzyme to a process stream, wherein the process stream comprises an amine oxide surfactant and hydrogen peroxide; and mixing the process stream and catalase enzyme. | 09-11-2008 |
20080261288 | Micro-Organ Device - A method for fabricating a micro-organ device comprises providing a microscale support having one or more microfluidic channels and one or more micro-chambers for housing a micro-organ and printing a micro-organ on the microscale support using a cell suspension in a syringe controlled by a computer-aided tissue engineering system, wherein the cell suspension comprises cells suspended in a solution containing a material that functions as a three-dimensional scaffold. The printing is performed with the computer-aided tissue engineering system according to a particular pattern. The micro-organ device comprises at least one micro-chamber each housing a micro-organ; and at least one microfluidic channel connected to the micro-chamber, wherein the micro-organ comprises cells arranged in a configuration that includes microscale spacing between portions of the cells to facilitate diffusion exchange between the cells and a medium supplied from the at least one microfluidic channel. | 10-23-2008 |
20080268514 | SAMPLE STORAGE FOR LIFE SCIENCE - Compositions and methods are disclosed for liquid storage of biological samples with recovery of substantially all biological activity and without refrigeration. Also disclosed are compositions and methods for automated storing, tracking retrieving and analyzing of such liquid-storable biological samples, including nucleic acids and proteins (including enzymes). RFID-tagged liquid-storable biological sample storage devices featuring liquid matrices are disclosed, as also are computer-implemented systems and methods for managing sample data. | 10-30-2008 |
20080268515 | Method and apparatus for production and refinement of microbial consortia for the generation of selective therapeutic chemical agents - A culturing fluid of defined bacterial consortia is placed within a cultivation apparatus to generate growths of either a bioconcretious or biocolloidal form within, or attached to surfaces exposed to, the culturing fluid. Such growths involve the interactive activities between all of the bacterial consortia to generate growths and economically attractive chemical daughter and end products within the fluid environment bounded by the cultivation apparatus. The cultivation apparatus allows the culturing fluid to flow along passageways that have alternating constricted and expanded zones in a manner that creates the growth of bioconcretious or biocolloidal structures within which the bacterial consortia interact to allow maintenance of these growth structures and stimulate the production of the desired chemical products of significance. The bacterial consortia generate either biocolloids or bioconcretions within an electrically charged field that is generated by the interaction of the consortia with dissimilar metal or carbon surfaces of the passageways. The grown interacting bacterial consortia and their culturing fluids can be used as sources of chemicals such as therapeutic agents that are anti-microbial, probiotic, anti-biotic, or anti-cancer agents. | 10-30-2008 |
20080280342 | Molecular Communication System - There is provided a molecular communication system capable of transmitting an information molecule in which predetermined information is encoded to a target destination under good controllability. The molecular communication system includes a molecular transmitter for transmitting the information molecule with prescribed information encoded, a molecular receiver for receiving the information molecule, and a molecule transmission channel extending between the molecular transmitter and the molecular receiver. The molecule transmission channel defines a transmission path formed of macromolecular (or polymer) materials, along which carrier molecules are circulating in a prescribed direction. The information molecule output from the molecular transmitter is loaded on the carrier molecule and carried to the molecular receiver. | 11-13-2008 |
20080286846 | Method and equipment for treating microcystin-containing water - The method for treating microcystin-containing water which detoxifies microcystin in the microcystin-containing water, the method comprises the step of: bringing the microcystin-containing water into contact with a | 11-20-2008 |
20080293116 | OVARY-SPECIFIC GENES AND PROTEINS - Ovary specific proteins O1 180, O1 184 and O1 236, polynucleotides encoding them, antibodies which are immunoreactive with them and vectors and host cells containing O1 180, O1 184 or O1 236 are provided. Also provided are methods for detecting cell proliferative or degenerative disorders of ovarian origin and which are associated with O1 180, O1 184 or O1 236. Further provided are methods for the evaluation of potential contraceptives using the proteins of the invention, as well as methods for the screening for genetic mutations in signaling pathways that are associated with some forms of human infertility or gynecological cancers, also using the proteins/mRNAs/genes of the invention. The proteins/mRNAs/genes of the invention may also be used as markers for identifying primary and metastatic neoplasms of ovarian origin and as indicators of developmental anomalies in prenatal screening procedures. Furthermore, assays of the proteins/mRNAs/genes of the invention can be used in diagnostic assays for detecting forms of infertility and other diseases, including germ cell tumors and polycystic ovary syndrome. The proteins of the invention may be useful targets for in vitro fertilization procedures or in enhancing the number of eggs that can be retrieved from the human donor, e.g., in enhancing the success rate. | 11-27-2008 |
20080293117 | HEAT RESISTANT BIOACTIVE COMPOSITION - A bioactive composition includes a hydrogel matrix. At least one protein is immobilized in the hydrogel matrix. The digestive protein has a half-life at least 1000 times longer than the half-life of a free digestive protein counterpart. | 11-27-2008 |
20090029435 | Deactivation of Linking Moieties in Antibody-Enzyme Conjugates - In some embodiments, the present invention pertains to a method for conjugating a first compound to a second compound wherein the conjugation involves an electrophilic moiety. The method comprises reacting the first compound with the second compound to form a conjugate. The improvement in embodiments of the present invention comprises adding a nucleophilic reagent to the conjugate wherein the nucleophilic reagent forms a neutral product upon reaction with unreacted electrophilic moieties of the conjugate. In some embodiments, the nucleophilic reagent is substantially non-reactive with disulfide bonds in the event that the conjugate comprises disulfide bonds. The conjugate formed is doubly deactivated because the other moiety for linking to the electrophilic moiety is also deactivated. | 01-29-2009 |
20090068716 | BIOLOGICAL INDICATOR AND METHOD FOR PRODUCING THE SAME - A biological indicator including a carrier and an indicator material, said indicator material adhering on the surface of the carrier, and having a contact portion being contact with the surface of the carrier and a non-contact portion being not in contact with the surface of the carrier, and wherein the carrier includes an adhering area having a adhering portion to which the indicator material adheres and a non-adhering area having an non-adhering portion to which the indicator material does not adhere. | 03-12-2009 |
20090111156 | METHOD OF FEEDING MICROBIAL ACTIVITY CONTROLLING SUBSTANCE, APPARATUS THEREFOR, AND MAKING USE OF THE SAME, METHOD OF ENVIRONMENTAL CLEANUP AND BIOREACTOR - Without using any pumps and controlling devices, to control microorganism's activity by supplying an activity controlling substance which is necessitated for the microorganism activity is realized. A microbial activity controlling material | 04-30-2009 |
20090209018 | Catalase decomposition of hydrogen peroxide in surfactants - A process comprising the steps of continuously adding a catalase enzyme to a process stream, wherein the process stream comprises an amine oxide surfactant and hydrogen peroxide; and mixing the process stream and catalase enzyme. | 08-20-2009 |
20090215144 | IMMOBILISATION OF BACTERIA TO A GEOLOGICAL MATERIAL - The invention relates to a method for immobilising bacteria in a material permeable to the bacteria, in particular a geological body, comprising forming a first zone comprising the bacteria in the material and allowing the first zone to move through at least part of the material; forming a second zone comprising an effective amount of a flocculating agent to the material and allowing the second zone to move through at least part of the material, wherein the zones are allowed to move such that the zones become at least partially overlapping and at least part of the bacteria flocculate, thereby becoming immobilised. | 08-27-2009 |
20090233343 | AFFINITY PURIFICATION OF PROTEIN - We describe fusion proteins comprising a bacterial immunity polypeptide and their use in affinity purification of protein complexes. | 09-17-2009 |
20090286298 | MICROFLUIDIC DEVICE, SYSTEM, AND METHOD FOR CONTROLLED ENCAPSULATION OF PARTICLES OR PARTICLE CLUSTERS - A microfluidic device for controlled encapsulation of particles of sub-millimetric dimensions, or clusters of such particles, the device comprising: a first duct for delivering a first liquid phase containing particles for encapsulating in suspension; a second duct for conveying a flow of a second liquid phase that is immiscible with said first liquid phase; the first duct opening out into the second duct and forming a fluidic junction therewith; at least one microfluidic duct for discharging the first liquid phase flowing in said first duct and provided with a mouth located upstream from said junction and liable to be obstructed, at least in part, by a particle in suspension, thereby causing pressure to rise in the first duct. The invention also provides a microfluidic system including such a device, and a method of encapsulation based on using such a device. | 11-19-2009 |
20090286299 | ENGINEERED LUCIFERASES - DNA sequencing techniques are important for a variety of research and diagnostic applications. Pyrosequencing is a “sequencing by synthesis” technique that makes use of luciferase. Modified luciferase enzymes and methods of DNA pyrosequencing are provided. Means of preparing and producing mutant luciferases that have enhanced selectivity for ATP or dATP are described. | 11-19-2009 |
20090325258 | Magnetic particle holding carrier and method for preparing the same - Provided is a magnetic particle holding carrier enabling automatization of treatment of a biological substance such as a protein by improving dispersibility of nano-size magnetic particles and suppressing nonspecific adsorption onto the wall of a container such as a pipette tip without damaging the properties of the nano-size magnetic particles such as a large solid-phase area and ability to arbitrarily design a functional protein, and provide a method for preparing the same. The magnetic particle holding carrier is formed of a micro-size nonmagnetic carrier and a plurality of nano-size magnetic particles bound to the carrier. | 12-31-2009 |
20090325259 | USE OF ADHESION MOLECULES AS BOND STRESS-ENHANCED NANOSCALE BINDING SWITCHES - Methods, compositions and devices are provided based on changing the binding strength of an adhesion molecule to a ligand by changing the force exerted on the bound complex between adhesion molecule and ligand, for example by changing the shear stress acting on the complex. The adhesion molecules and their ligands of this invention bind more tightly when a force-activated bond stress, such as shear force, applied to the adhesion molecules is increased, and bond less tightly when the stress is decreased. The adhesion molecules can be isolated from their sources in nature or can remain attached to their natural sources. They can be engineered, e.g., by altering their amino acid sequences or by binding to antibodies or other particles, to alter their binding properties. They can be attached to a wide range of substrates including particles and device surfaces to form adhesive systems which are capable of sticking to other particles and/or device surfaces to which ligands for the adhesion molecules have been attached. The adhesion molecules and ligands described herein can be used to control binding and release of components of an adhesive system by increasing or decreasing the force-activated bond stresses applied to the adhesion molecules. | 12-31-2009 |
20090325260 | CIS REACTIVE OXYGEN QUENCHERS INTEGRATED INTO LINKERS - The present invention provides methods and compositions for performing illuminated reactions, particularly sequencing reactions, while mitigating and/or preventing photodamage to reactants that can result from prolonged illumination. In particular, the invention provides methods and compositions for incorporating photoprotective agents into conjugates comprising reporter molecules and nucleoside polyphosphates. | 12-31-2009 |
20100021984 | Microfluidic Droplet Encapsulation - Microfluidic devices and methods for the encapsulation of particles within liquid droplets are disclosed. The new methods and devices form 1-100 picoliter-size monodisperse droplets containing the particles, such as single cells, encapsulated in individual liquid droplets. The particles can be encapsulated in droplets of a fluid by passing a fluid containing the particles through a high aspect-ratio microchannel to order the particles in the fluid, followed by forming the fluid into droplets. The resulting fraction of the liquid droplets with a single particle (e.g., a cell) is higher than the corresponding fraction of single-particle liquid droplets predicted by Poisson statistics. | 01-28-2010 |
20100021985 | MECHANICAL PROCESS FOR CREATING PARTICLES IN FLUID - A method of producing at least one of microscopic and submicroscopic particles includes providing a template that has a plurality of discrete surface portions, each discrete surface portion having a surface geometry selected to impart a desired geometrical property to a particle while being produced; depositing a constituent material of the at least one of microscopic and submicroscopic particles being produced onto the plurality of discrete surface portions of the template to form at least portions of the particles; separating the at least one of microscopic and submicroscopic particles comprising the constituent material from the template into a fluid material, the particles being separate from each other at respective discrete surface portions of the template; and processing the template for subsequent use in producing additional at least one of microscopic and submicroscopic particles. A multi-component composition includes a first material component in which particles can be dispersed, and a plurality of particles dispersed in the first material component. The plurality of particles is produced by methods according to embodiments of the current invention. | 01-28-2010 |
20100035323 | Methods of using a multiple sheath flow device for the production of microcapsules - The present invention provides methods for preparing microcapsules, each microcapsule comprising a semipermeable membrane, an aqueous core, one or more enzymes in the aqueous core, and one nucleic acid template in the aqueous core. Microcapsules are prepared by flowing (i) an innermost fluid flow comprising at least one enzyme and at least one nucleic acid template, (ii) a middle fluid flow comprising a semipermeable membrane forming material, and (iii) an outer fluid flow comprising a solution or gas through a multiple sheath flow device. The outer fluid flow entrains the innermost fluid flow and middle fluid flow in the aperture of the multiple sheath flow device. The fluids exit the multiple sheath flow device as a liquid jet resulting in microcapsules. | 02-11-2010 |
20100062508 | Droplet Actuator Loading and Target Concentration - A droplet actuator and method of providing a droplet comprising an target substance on the droplet actuator, and including discrete flow and continuous flow functionality. Discrete flow function is controlled by electrodes arranged for conducting droplet operations on a substrate surface. The continuous flow function includes a fluid path arranged for flowing a fluid therethrough. The discrete flow and continuous flow functions may be by a barrier, including a second fluid path through the barrier. The continuous flow function may include a capture surface comprising a component having an affinity for the target substance. Methods of the invention may include flowing a fluid comprising the target substance through the fluid path; capturing the target substance on the capture surface; and forming a droplet in the discrete flow region via the second fluid path and the electrodes comprising the captured target substance. | 03-11-2010 |
20100075391 | COMPOSITION AND METHOD FOR HANDLING TISSUE SAMPLES - The present invention relates to a composition and method for handling tissue samples for analysis. In particular the present invention relates to a composition and method for orientating tissue for histological and/or pathological laboratory analysis. | 03-25-2010 |
20100159557 | Pelletization Process to Control Filamentous Fungi Morphology for Enhanced Reactor Rheology Bioproduct Formation - Filamentous fungi are grown in pellet form by culturing the filamentous fungi in liquid culture under one or more of the following conditions: 1) with addition of particulate substrates: 2) using spores which have been stored for a period of time prior to inoculation; and 3) using high spore inoculum concentrations. | 06-24-2010 |
20100167372 | Device And Method For Separation, Concentration, And/Or Purification Of Cells - The present invention relates to methods and apparatuses for cell separation. In particular, the invention relates to separation of a particular cell type from a mixture of different cell types based on the differential rolling property of the particular cell type on a substrate coated with molecules that exhibits adhesive property with the particular cell type. The molecules can be directly coated on the surface or coated on nanoparticles that are adhered to the surface. This technology is adaptable for use in implantable shunts and devices for cell trafficking or tumor neutralization. | 07-01-2010 |
20100178683 | HAIR FOLLICLE GRAFT FROM TISSUE ENGINEERED SKIN - The present invention provides a hair graft comprising (a) tissue engineered skin comprising a tissue engineered epidermal layer, a tissue engineered dermal layer, and hair follicle progenitor cells and (b) a scaffold. The invention also provides methods of making and using the hair grafts of the present invention. | 07-15-2010 |
20100216209 | IMMOBILIZED LIPASE AND METHOD FOR PRODUCING THE SAME - Disclosed is an immobilized lipase which is improved in transesterification activity when compared with conventional immobilized lipases. Specifically disclosed is an immobilized lipase remarkably improved in transesterification activity, which is obtained by immobilizing an oil-in-water emulsion containing an enzyme having a lipase activity, a polymer emulsifier and a fat/oil to a carrier. | 08-26-2010 |
20100216210 | METHODS AND COMPOSITIONS FOR REPAIR OF CARTILAGE USING AN IN VIVO BIOREACTOR - Methods and compositions for the biological repair of cartilage using a hybrid construct combining both an inert structure and living core are described. The inert structure is intended to act not only as a delivery system to feed and grow a living core component, but also as an inducer of cell differentiation. The inert structure comprises concentric internal and external and inflatable/expandable balloon-like bio-polymers. The living core comprises the cell-matrix construct comprised of HDFs, for example, seeded in a scaffold. The method comprises surgically removing a damaged cartilage from a patient and inserting the hybrid construct into the cavity generated after the foregoing surgical intervention. The balloons of the inert structure are successively inflated within the target area, such as a joint, for example. Also disclosed herein are methods for growing and differentiating human fibroblasts into chondrocyte-like cells via mechanical strain. | 08-26-2010 |
20100285560 | RETICULOCYTE MIMETICS AND METHOD OF PREPARATION OF THE SAME - In one aspect of the present disclosure there is provided a method for preparing reticulocyte mimetics. In another aspect of the present disclosure there are provided reticulocyte mimetics obtained using the method. In yet another aspect of the present disclosure there is provided a whole blood reference control including the reticulocyte mimetics as provided. In still another aspect of the present disclosure there is provided a composition useful for preparing reticulocyte mimetics. | 11-11-2010 |
20100297723 | HEAT-STABLE CARBONIC ANHYDRASES AND THEIR USE - The present invention relates to use of heat-stable carbonic anhydrase in CO | 11-25-2010 |
20110003358 | CULTURES OF GFAP+ NESTIN+ CELLS THAT DIFFERENTIATE TO NEURONS - Cultures of cells immunoreactive for glial fibrillary acidic protein (GFAP), as well as for the intermediate filament marker nestin were grown in a medium including epidermal growth factor (EGF) and serum. The cultured cells had the morphology of astroglial cells. The cells can be proliferated in adherent or suspension cultures. Depending on the culture conditions, the cells can be induced to differentiate to neurons or glial cells. The cultures can be expanded over a large number of passages during several months, and survive, express an astroglial phenotype and integrate well after transplantation into both neonatal and adult rat forebrain. | 01-06-2011 |
20110003359 | BIODEVICE - Disclosed is a biodevice which has a porous membrane ( | 01-06-2011 |
20110014674 | CARBON NANOTUBE BINDING PEPTIDES - Peptides have been generated that have binding affinity to carbon nanostructures and particularly carbon nanotubes. Peptides of or the invention are generally about twelve amino acids in length. Methods for generating carbon nanotube binding peptides are also disclosed. | 01-20-2011 |
20110045567 | Method for producing entrapping immobilization pellets, apparatus for producing the same, and entrapping immobilization pellets - It is possible to eliminate fluctuation in the pellet strength of the entrapping immobilization pellets according to production lots, and constantly and stably produce the entrapping immobilization pellets having high pellet strength regardless of the production lots. An apparatus for producing entrapping immobilization pellets by polymerizing an immobilizing material into a gel in the presence of an activated sludge to entrap and immobilize microorganisms in the immobilizing material, the apparatus including: a line mixer which mixes an activated sludge with an immobilizing material to prepare a raw material solution, a temperature sensor which measures a temperature of the prepared raw material solution, an addition pump which adds a polymerization initiator to the prepared raw material solution, and a controller which controls the addition pump according to the measured temperature to control an additive rate of the polymerization initiator. | 02-24-2011 |
20110053242 | Immunoaffinity isolation of modified peptides from complex mixtures - The invention provides methods for isolating a modified peptide from a complex mixture of peptides, the method comprising the steps of: (a) obtaining a proteinaceous preparation from an organism, wherein the preparation comprises modified peptides from two or more different proteins; (b) contacting the preparation with at least one immobilized modification-specific antibody; and (c) isolating at least one modified peptide specifically bound by the immobilized modification-specific antibody in step (b). The method may further comprise the step of (d) characterizing the modified peptide isolated in step (c) by mass spectrometry (MS), tandem mass spectrometry (MS-MS), and/or MS | 03-03-2011 |
20110081700 | Methods of Purifying Recombinant Adamts13 and Other Proteins and Compositions Thereof - Provided herein are methods for purifying recombinant A Disintegrin-like and Metallopeptidase with Thrombospondin Type 1 Motif 13 (ADAMTS13) protein from a sample. The method comprises enriching for ADAMTS13 protein by chromatographically contacting the sample with hydroxyapatite under conditions that allow ADAMTS13 protein to appear in the eluate or supernatant from the hydroxylapatite. The methods may further comprise tandem chromatography with a mixed mode cation exchange/hydrophobic interaction resin that binds ADAMTS13 protein. Additional optional steps involve ultrafiltration/diafiltration, anion exchange chromatography, cation exchange chromatography, and viral inactivation. Also provided herein are methods for inactivating virus contaminants in protein samples, where the protein is immobilized on a support. Also provided herein are compositions of ADAMTS13 prepared according to said methods. | 04-07-2011 |
20110104779 | Heat-stable carbonic anhydrases and their use - The present invention relates to use of heat-stable carbonic anhydrase in CO | 05-05-2011 |
20110117621 | Aldehyde Tags, Uses Thereof in Site-Specific Protein Modification - The invention features compositions and methods for site-specific modification of proteins by incorporation of an aldehyde tag. Enzymatic modification at a sulfatase motif of the aldehyde tag through action of a formylglycine generating enzyme (FGE) generates a formylglycine (FGly) residue. The aldehyde moiety of FGly residue can be exploited as a chemical handle for site-specific attachment of a moiety of interest to a polypeptide. | 05-19-2011 |
20110124078 | SCALABLE CELL CULTURE BIOREACTOR AND CELL CULTURE PROCESS - The present invention relates to a scaleable bioreactor comprising at least one cassette comprising a manifold and an arrangement of hollow fibre membranes; an upper headplate; and a lower headplate, wherein the cassette(s) are modular components adapted to co-operate with each other and the headplates to define an internal extracapillary culture space (ECS) and wherein the arrangement of hollow fibre membranes includes a discrete inlet and outlet. The invention further relates to a kit for such a bioreactor, a cassette for use in such a bioreactor and a process for exploiting the metabolism of cells and/or microorganisms, the process including the step of utilising a bioreactor according to the invention. | 05-26-2011 |
20110129892 | PRODUCTION OF CELL TISSUE HAVING THREE-DIMENSIONAL STRUCTURE USING ELECTROSTATIC INK JET PHENOMENON - According to the present invention, a method and an apparatus for producing a cell tissue of blood vessels or the like with the use of an electrostatic ink jet phenomenon are provided. | 06-02-2011 |
20110136199 | BACTERIA THAT REDUCE CONTENT OF HEAVY METALS IN PLANT - This invention relates to bacteria having a function of reducing the content of heavy metals in plants, a method for reducing the content of heavy metals in plants with the use of such bacteria, and a composition comprising, as an active ingredient, such bacteria. | 06-09-2011 |
20110165646 | Super Sparger Microcarrier Beads and Precision Extrusion Deposited Poly-Epsilon-Caprolactone Structures for Biological Applications - In on aspect, the invention includes a microcarrier bead having a porous three-dimensional core having (a) a polymeric porous three-dimensional body having porosity of about 15 to about 90% such that at least 99% of pores are interconnected and have diameters of at most 200 microns, (b) an outer protective layer and optionally (c) a filler. In another aspect, the invention includes a method of making an artificial scaffold wherein a scaffolding material is extruded into a coolant and thereby creating a porous material having a porosity of between 15-90% such that at least 99% of pores are interconnected and have diameters of at most 200 microns. | 07-07-2011 |
20110189749 | TRAPPING, RECYCLING, AND OTHER TECHNIQUES INVOLVING CATALYSTS - Trapping, recycling, and other techniques involving catalysts are provided by this invention. The present invention provides for the retention of catalysts and other immobilized entities within a reaction region. In one aspect, the invention promotes such retention by incorporating support material regions including relatively little (or, in some cases, substantially no) catalyst (and thus, a relatively large number of catalyst adsorption sites) which can trap catalyst as it is transported through the downstream support material. In some cases, such arrangements can be achieved by using multiple beds arranged in series. In other instances, the amount of catalyst can be varied within a single bed to achieve the desired effect. The embodiments described herein can be used in systems in which the catalyst is covalently or non-covalently associated with the support surface. | 08-04-2011 |
20110189750 | Carbonic Anhydrase Enhanced Reaction Methods and Formulations - Disclosed is a formulation for the absorption of CO | 08-04-2011 |
20110195474 | METHODS OF USING A MULTIPLE SHEATH FLOW DEVICE FOR THE PRODUCTION OF MICROCAPSULES - The present invention provides methods for preparing micro-capsules, each microcapsule comprising a semipermeable membrane, an aqueous core, one or more enzymes in the aqueous core, and one nucleic acid template in the aqueous core. Microcapsules are prepared by flowing (i) an innermost fluid flow comprising at least one enzyme and at least one nucleic acid template, (ii) a middle fluid flow comprising a semipermeable membrane forming material, and (iii) an outer fluid flow comprising a solution or gas through a multiple sheath flow device. The outer fluid flow entrains the innermost fluid flow and middle fluid flow in the aperture of the multiple sheath flow device. The fluids exit the multiple sheath flow device as a liquid jet resulting in microcapsules. | 08-11-2011 |
20110201077 | COMPOSITION, METHOD, AND KIT FOR PREPARING PLASMIN - A streptokinase immobilized on a surface, in particular an immobilized plasmin-resistant streptokinase, and compositions, methods and kits of utilizing same for preparing plasmin are provided. | 08-18-2011 |
20110207195 | METHOD OF IMMOBILIZING A PROTEIN OR MOLECULE VIA A MUTANT DEHALOGENASE THAT IS BOUND TO AN IMMOBILIZED DEHALOGENASE SUBSTRATE AND LINKED DIRECTLY OR INDIRECTLY TO THE PROTEIN OR MOLECULE - A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase which is more stable than the bond formed between the wild-type hydrolase and the substrate and has at least two amino acid substitutions relative to the wild-type hydrolase. Substrates for hydrolases comprising one or more functional groups are also provided, as well as methods of using the mutant hydrolase and the substrates of the invention. Also provided is a fusion protein capable of forming a stable bond with a substrate and cells which express the fusion protein. | 08-25-2011 |
20110212500 | FLOW-STRETCH-FLEXURE BIOREACTOR - Described herein is a bioreactor system and modules capable of developing physiologically relevant fluid-induced shear stresses and regionally specific flow patterns to scaffold specimens and which can couple these stresses to cyclic flexure and/or stretch states. Methods of use of the bioreactor system and module also are provided. | 09-01-2011 |
20110212501 | 3-DIMENSIONAL MULTI-LAYERED HYDROGELS AND METHODS OF MAKING THE SAME - Embodiments of the invention provide three dimensional multi-layered hydrogel constructs with embedded channels, living cells and bioactive agents, and methods for making three dimensional multi-layered hydrogel constructs. The constructs can have bioactive agents to support the living cells. The multi-layered constructs can have channels for perfusion purposes and layers of different hydrogel materials. | 09-01-2011 |
20110217749 | METHOD FOR THE CULTIVATION OF PRIMARY CELLS AND FOR THE AMPLIFICATION OF VIRUSES UNDER SERUM FREE CONDITIONS - The present invention relates to a method for the cultivation of primary cells. The primary cells are cultivated in a serum free medium comprising a factor selected from the group consisting of growth factors and attachment factors. | 09-08-2011 |
20110229953 | METHOD FOR PRODUCING DIFFERENT POPULATIONS OF MOLECULES OR FINE PARTICLES WITH ARBITRARY DISTRIBUTION FORMS AND DISTRIBUTION DENSITIES SIMULTANEOUSLY AND IN QUANTITY, AND MASKING MEMBER THEREFOR - The formation in quantity of various different populations of a substance being studied with multiple combinations of distribution form and distribution density by dripping a suspension of a single concentration of the substance onto a masking member of a certain specified structure placed on a substrate by making use of the sedimentation of said substance. | 09-22-2011 |
20110287508 | BIOREACTORS FOR TISSUE ENGINEERING - Bioreactors and methods of using them to produce tissue engineered products or culture cells are disclosed, and more particularly on the development of a tissue and cell culture method based upon an expanded bed bioreactor in which an initial resting bed of particles on which or in which cells are attached, encapsulated or immobilised have a fluid passed upwards through the bed to form an expanded bed in which the fluid acts to separate the particles, i.e. under plug flow conditions to enable the relative positions of the particles to be maintained during the step of culturing the cells to form tissue and helps to reduce collisions between particles and turbulent flow or convective mixing. | 11-24-2011 |
20110300598 | Device and Method Using Integrated Neuronal Cells and an Electronic Device - The present invention provides a device of integrated neuronal cells interfaced with an electronic device and a method of producing the same. | 12-08-2011 |
20120028328 | COATED SUBSTRATES AND METHODS OF PREPARING THE SAME - Disclosed herein are coated articles and methods of preparing the same. | 02-02-2012 |
20120064596 | HIGH-DENSITY SPOT SEEDING FOR TISSUE MODEL FORMATION - A method for making a tissue includes seeding cells at a selected concentration on a support to form a cell spot, incubating the cells to allow the cells to partially attach, rinsing the cells to remove any unattached cells, adding culture medium to enable the cells to proliferate at a periphery of the cell spot and to differentiate toward a center of the cell spot, and further incubating the cells to form the tissue. The cells may be C2C12 cells or other subclones of the C2 cell line, H9c2(2-1) cells, L6 cells, L8 cells, QM7 cells, Sol8 cells, G-7 cells, G-8 cells, other myoblast cells, cells from other tissues, or stem cells. The selected concentration is in a range from about 1×10 | 03-15-2012 |
20120077246 | Methods and Devices for Capturing Circulating Tumor Cells - A method of capturing a Circulating Tumor Cell (CTC) from a sample includes introducing a sample into a microfluidic device having a cell capture surface and a flow modification surface under conditions that allow a CTC to bind to a cell rolling-inducing agent and a capturing agent disposed on the cell capture surface. The flow modification surface induces a rotational flow within the sample as it flows through the microfluidic device. | 03-29-2012 |
20120107899 | Heat-Stable Carbonic Anhydrases and Their Use - The present invention relates to use of | 05-03-2012 |
20120122177 | Viral Infection Enhancing Peptide - The invention relates to a peptide derived from HIV-1 gp120 which forms insoluble aggregates when introduced into an aqueous solution and its use for enhancing viral infection of cells. In addition, the invention comprises methods for enhancing viral infection of cells, for concentrating a virus and for separating a virus from a fluid. | 05-17-2012 |
20120178137 | CELL-MEDIATED SILICA SOL-GEL ENCAPSULATION OF LIVING CELLS AND TISSUES - Methods are provided for the encapsulation of living cells with a silica glass layer. The methods comprise adding a sol solution to cells in buffered media, forming a sol-gel layer on the cells and then diluting the media or removing the cells from the media. | 07-12-2012 |
20120184011 | Emulsion Compositions - An emulsion is useful in allowing a wide variety of gene products to be expressed via eukaryotic in vitro expression. The emulsion comprises a silicone based surfactant, a hydrophobic phase and a hydrophilic phase; wherein the hydrophilic phase comprises a plurality of compartments containing a functional in vitro eukaryotic expression system. | 07-19-2012 |
20120196343 | SELF-ASSEMBLING MULTICELLULAR BODIES AND METHODS OF PRODUCING A THREE-DIMENSIONAL BIOLOGICAL STRUCTURE USING THE SAME - Structures and methods for tissue engineering include a multicellular body including a plurality of living cells. A plurality of multicellular bodies can be arranged in a pattern and allowed to fuse to form an engineered tissue. The arrangement can include filler bodies including a biocompatible material that resists migration and ingrowth of cells from the multicellular bodies and that is resistant to adherence of cells to it. Three-dimensional constructs can be assembled by printing or otherwise stacking the multicellular bodies and filler bodies such that there is direct contact between adjoining multicellular bodies, suitably along a contact area that has a substantial length. The direct contact between the multicellular bodies promotes efficient and reliable fusion. The increased contact area between adjoining multicellular bodies also promotes efficient and reliable fusion. Methods of producing multicellular bodies having characteristics that facilitate assembly of the three-dimensional constructs are also provided. | 08-02-2012 |
20120196344 | CYTOBLOCK PREPARATION SYSTEM AND METHODS OF USE - An apparatus and method that may be used for collecting target cells or tissue and preparing a cell block are disclosed. | 08-02-2012 |
20120214219 | SEPARATION OF A TARGET SUBSTANCE FROM A FLUID OR MIXTURE USING ENCAPSULATED SORBENTS - Method and apparatus for separating a target substance from a fluid or mixture. Capsules having a coating and stripping solvents encapsulated in the capsules are provided. The coating is permeable to the target substance. The capsules having a coating and stripping solvents encapsulated in the capsules are exposed to the fluid or mixture. The target substance migrates through the coating and is taken up by the stripping solvents. The target substance is separated from the fluid or mixture by driving off the target substance from the capsules. | 08-23-2012 |
20120244594 | Immunoaffinity isolation of modified peptides from complex mixtures - The invention provides methods for isolating a modified peptide from a complex mixture of peptides, the method comprising the steps of: (a) obtaining a proteinaceous preparation from an organism, wherein the preparation comprises modified peptides from two or more different proteins; (b) contacting the preparation with at least one immobilized modification-specific antibody; and (c) isolating at least one modified peptide specifically bound by the immobilized modification-specific antibody in step (b). The method may further comprise the step of (d) characterizing the modified peptide isolated in step (c) by mass spectrometry (MS), tandem mass spectrometry (MS-MS), and/or MS | 09-27-2012 |
20120270294 | STEM CELL CAPTURE AND IMMOBILIZATION COATINGS FOR MEDICAL DEVICES AND IMPLANTS - Constructs and methods for immobilizing stem and other precursor cells, as well as other bioactive materials of therapeutic value on the surfaces of medical devices, such as bone, cartilage, spinal and tooth implants, are described herein. The present invention has broad application in the incorporation of bioactive and therapeutic materials in or on a medical implant or other interventional device, having particular value in enabling the real-time, utilization by medical personnel of bioactive materials extracted from the patient and subsequently reintroduced and immobilized in an implant device. | 10-25-2012 |
20120282667 | METHOD FOR POSITIONING BIOLOGICAL SAMPLES IN A MICROSCOPIC ARRANGEMENT - The invention relates to methods for positioning at least one preferably biological specimen in the specimen space of a microscope arrangement, and to devices for carrying out these methods. Methods and devices arc proposed, wherein the specimen's orientation relative to a detection objective's optical axis can be repeatedly changed and, in doing so, the specimen is held so that a substantially unobstructed view of the specimen is ensured from every detection direction. In different constructional variants, the specimen is held at a supporting device by adhesive forces or by a flowing medium, the specimen is held at a capillary opening by capillary action, or at least one specimen is embedded in a body of transparent gel, and the gel body is fixed in the specimen space by means of a rotatable holding device, and the detection direction is changed by rotating the holding device by a given angle of rotation. | 11-08-2012 |
20120288911 | BIOREACTOR FOR ENGINEERED TISSUE - A system for generating a tissue construct includes a mixing chamber, a piston chamber, a reaction chamber, and a pump. The mixing chamber is configured to receive a hydrogel solution and a cell suspension solution. The piston chamber includes a first piston and is configured to receive a mixture of the hydrogel solution and the cell suspension solution from the mixing chamber. The first piston is configured to push the mixture through one or more capillaries into the reaction chamber. The reaction is configured to receive the mixture and a cross-linking initiator. The pump is configured to move the mixture through the reaction chamber such that the mixture and the cross-linking initiator combine to form an encapsulated cell material. | 11-15-2012 |
20130029396 | Multifunctional Biomemory Device - The present disclosure relates to a multifunctional biomemory device in which a protein having a redox potential substituted with a metal ion is directly immobilized on a substrate. The present disclosure provides an operating method in which the redox state of the protein is controlled by applying three different potentials. The present disclosure provides a biomemory device in which the metal ion of a metalloprotein is substituted to allow for artificial control of the redox potential. The present disclosure provides a new-concept biomemory device as an information storage device based on the principle of electron transfer of a naturally occurring biomolecule. | 01-31-2013 |
20130040355 | PARTICLE BINDING - A method of binding bacteriophage to particles. The method comprising the steps of exposing the particles to an electrical discharge and then mixing the activated particles with the bacteriophage. The bacteriophage are then bound to the particles. | 02-14-2013 |
20130115671 | ENZYMES FROM CONIDIOBOLUS BREFELDIANUS AND PROCESS FOR PREPARATION THEREOF - The instant invention relates to a fungus of the | 05-09-2013 |
20130137155 | METHODS AND DEVICES FOR ENCAPSULATING CELLS - Molds for making cell aggregation devices include upper and lower surfaces. Methods of aggregating cells include depositing cells on in a seeding chamber, incubating the cells and removing aggregated cells. Devices for encapsulating aggregates of cells include biocompatible, bio-sustainable substrates compartments and a coating of a biocompatible, bio-sustainable polymer that completely surrounds the substrate and cell-encapsulating compartments. | 05-30-2013 |
20130149768 | CATALYST FUNCTIONALIZED BUFFER SORBENT PEBBLES FOR RAPID SEPARATION OF CARBON DIOXIDE FROM GAS MIXTURES - A method for separating CO | 06-13-2013 |
20130210110 | Method for Changing Surface Properties of a Substrate from Immobilized Biomolecules - A method that modifies surface properties of a substrate by manipulating the immobilized biomolecules in mild biological condition. The manipulation comprised steps of: providing a biomolecule combined with at least one ssDNA combined with a first protein through an affinity binding tag; adding a second ssDNA conjugated with a second protein with a concentration greater than that of the first protein; and replacing the first protein on the ssDNA with the second protein through chemical competitive principle. The invention may comprise the steps with proper design of biotinylated DNA probes, the functionalized ssDNA nanotemplates can be recovered to its unbound state through a thermodynamic principle. | 08-15-2013 |
20130236944 | METHODS FOR THE INACTIVATION OF ANTIBIOTICS - The invention relates to methods for inactivating antibiotics in the environment. The invention further relates to the use of a laccase, a lipase or a cellulase for inactivation of antibiotics. It also relates to compositions to decontaminate the polluted environment and to prevent the pollution of the environment by inactivating antibiotics from waste and wastewater effluents before they reach the environment. | 09-12-2013 |
20130302873 | Methods of Making Material Coatings for Self-cleaning and Self-decontamination of Metal Surfaces - A method of making a composite structure exhibiting the ability to degrade chemical or biological agents upon contact comprising a substrate to be protected from the deleterious effects of chemical or biological agents possessing surface groups capable of deactivating materials having the ability to degrade chemical or biological agents, a buffer film, coated onto the substrate, that blocks the ability of the substrate surface groups to deactivate the materials having the ability to degrade chemical or biological agents, and a protective film, coated onto the buffer film, containing materials having the ability to degrade chemical or biological agents encapsulated in or comprising the outer surface of the protective film. | 11-14-2013 |
20130330799 | CRUDE OIL DEGRADING MICROORGANISMS AND METHODS FOR THEIR ENHANCEMENT - Certain embodiments are directed to methods of enhancing the petroleum degrading abilities of bacteria and the resulting bacterial composition. In certain aspects the bacteria are selected for degradation of a petroleum having a particular composition profile and/or for environmental robustness. | 12-12-2013 |
20130330800 | Methods For Fermentation of Xylose and Hexose Sugars - Methods and systems for the isomerization and fermentation of xylose and hexose sugars using an immobilized enzyme system capable of sustaining two different pH microenvironments in a single vessel are disclosed. Bilayer particles are dispersed in a mixture comprising an ionic borate source and xylose. The bilayer particles have a first region with a first enzymatic activity comprising xylose isomerase and a pH of 6 or above, and a second region having a second enzymatic activity at an acidic pH. | 12-12-2013 |
20140099693 | HIGH CONCENTRATION H2S ELIMINATION SYSTEM AND HIGH CONCENTRATION H2S ELIMINATION METHOD - A high concentration H | 04-10-2014 |
20140099694 | METHOD FOR OBTAINING A TISSUE-ENGINEERING PRODUCT FOR REGENERATION OF CARTILAGINOUS TISSUE - The present invention relates to a method for obtaining a tissue engineering product designed to regenerate cartilage tissue, said product comprising expanded bone marrow mesenchymal cells, a non-cellular matrix and a fibrin gel, the method comprising the steps of: (a) expanding the mesenchymal cells; (b) conjugating the mesenchymal cells to the matrix; (c) washing the product obtained in step (b); and (d) mixing the product obtained in step (c) with a fibrin gel. | 04-10-2014 |
20140113346 | THERMOSTABLE CARBONIC ANHYDRASES AND METHODS OF USE THEREOF - The present compositions and methods relate to a thermostable carbonic anhydrases, polynucleotides encoding the carbonic anhydrase, and methods of make and/or use thereof. Formulations containing the carbonic anhydrase are suitable for use in extracting carbon dioxide. | 04-24-2014 |
20140127773 | COMPOSITIONS AND METHODS FOR CAPTURE AND ELUTION OF BIOLOGICAL MATERIALS VIA PARTICULATES - Lysing may include agitating a specimen in a chamber along with a medium that includes a particulate lysing material that has an affinity for a biological material. Lysing material may include beads or other material which may be coated that facilitates binding. The medium may include a fluid with a high salt or low pH level. Binding of biological materials to solid surfaces may be induced by particular media. The biological material may be eluted by lowering a concentration of salt or increasing a pH level. Lysing materials with two or more different affinities may be employed. Lysing materials may include particles of different sizes. Heating may be used. Lysing may be performed in a flow through apparatus. Surfaces of solid materials may be modified to capture bacteria with high cell wall lipid content. | 05-08-2014 |
20140134699 | NOVEL STABILISATION METHOD FOR VIRUSES OR BACTERIA - The present invention relates to a method for stabilising viruses or bacteria, the method comprising embedding the viruses or bacteria in an aqueous solution, wherein the solution comprises: (i) at least three different amino acids; or (ii) at least one dipeptide or tripeptide and wherein the solution is free or substantially free of sugar(s), silanes and protein(s). | 05-15-2014 |
20140329289 | ANTI-FH APTAMERS, METHOD FOR PRODUCING SAME, AND USES THEREOF - The invention relates to nucleic acid aptamers binding specifically to factor H, to a method for obtaining same, and to the uses thereof, in particular for the purposes of purifying factor H. | 11-06-2014 |
20150037865 | COMPOSITIONS FOR CAUSING, ENHANCING, AND/OR EXPEDITING OXO-BIODEGRADATION OF ARTICLES AND METHODS OF PRODUCTION AND USE THEREOF - Kits and assemblies for causing, enhancing, and/or expediting consumption of an article by at least one biodegradative living organism are disclosed. The kits and assemblies include at least one additional living organism that enhances and/or expedites consumption of the article by the at least one biodegradative living organism. Methods of producing and using same are also provided. | 02-05-2015 |
20150050711 | DEVICE FOR MANUFACTURING POLYMER FIBERS AND USES THEREOF - There is provided a device, and related method and uses, for drawing a polymer fiber, the device comprising: a. at least two polymer compartments, wherein each polymer compartment is capable of retaining a polymer solution, and wherein adjacent compartments comprise different polymer solutions; and b. a slider comprising at least one prong, wherein the prong is capable of contacting the different polymer solutions, and wherein the slider is arranged in a retractable manner from the at least two polymer compartments. There is further provided a system and a related method for manufacturing a polymer fiber. | 02-19-2015 |
20150111278 | Heat-Stable Carbonic Anhydrases and Their Use - The present invention relates to use of | 04-23-2015 |
20150125922 | APPARATUS FOR PREPARING ENZYME-IMMOBILIZED BEADS AND METHOD FOR PREPARING ENZYME-IMMOBILIZED BEADS USING SAME - The present invention relates to an apparatus for preparing enzyme-immobilized beads used for preparation of tagatose, and a method for preparing enzyme-immobilized beads using the same. More specifically, the present invention relates to an apparatus for preparing enzyme-immobilized beads, comprising a nozzle with an inside diameter of 0.1-1 mm having a cylindrical lower end and comprising a cut-type liquid outlet (cut perpendicularly to the vertical axis of the nozzle) formed at the lower end, and a method for preparing enzyme-immobilized beads using the same. | 05-07-2015 |
20150315549 | BIOREACTOR COMPRISING IMMOBILIZED ENZYME, METHOD FOR IMPROVING ACTIVITY OF IMMOBILIZED ENZYME, AND BIOFUEL CELL - According to the present invention, the enzyme activity of an immobilized enzyme is improved regardless of enzyme type. A bioreactor, comprising an immobilized enzyme and a heterocyclic compound containing nitrogen and carbon atoms and having 5- or 6-membered ring, which form a reaction field, wherein the immobilized enzyme is allowed to cause an enzymatic reaction in the reaction field is, provided. | 11-05-2015 |
20150375453 | MULTIDISPENSOR CARTESIAN ROBOTIC PRINTER - Disclosed are systems, compositions, and methods for three-dimensional (3D) printing. An example system includes a plurality dispensers configured to deposit materials from their tips and a printing surface for receiving the materials. The system includes a position sensing detector configured to detect positions of the tips of the dispensers and the location and dimensions of the printing surface. The system includes a robotic positioning device configured to drive the dispensers. The system also includes a control unit configured to receive and map in a 3D space the positions of the tips of the dispensers and the position and dimensions of the printing surface. The control unit is further configured to control the robotic positioning device to drive the dispensers relative to the printing surface in the 3D space, and to independently deposit materials on the printing surface, or on material deposited on the printing surface. | 12-31-2015 |
20160010054 | Methods of Patterning Cells on a Surface of a Substrate and Programmed Assembly of Three-Dimensional Living Tissues | 01-14-2016 |
20160046923 | METHOD FOR IMMOBILIZING AND RELEASING MICROORGANISM - Intended is to provide a more practical technique for immobilizing a microorganism using an adhesive protein AtaA derived from | 02-18-2016 |
20160102283 | MICROFLUIDIC DEVICE AND SYSTEM FOR PRECISELY CONTROLLING AND ANALYZING SHEAR FORCES IN BLAST-INDUCED TRAUMATIC BRAIN INJURIES - Embodiments of a microfluidic system and method for stimulating a blast shock wave that supports a short and defined laminar flow of a liquid media solution through a microfluidic device such that sheer stress on neural tissue disposed within the microfluidic device is precisely controlled are disclosed. The microfluidic system includes a pneumatic device applies a blast shock wave having a quick rise time across a microfluidic channel of the microfluidic device. The microfluidic device includes an inlet reservoir in fluid flow communication with an outlet reservoir through the microfluidic channel. The inlet and outlet reservoirs are secured to a top structure which is attached to a bottom structure that collectively defines the microfluidic channel with a cover slip that is attached to the underside of the bottom structure. | 04-14-2016 |
20160135446 | CELL STABILIZATION - The present invention relates to stabilization of cells at ambient temperatures. More particularly, the present invention relates to formulations, compositions, kits and methods that allow dehydration and rehydration of cells and dramatically increased recovery of functional cells after dry storage at room temperature. | 05-19-2016 |
20160374900 | LOADING SYSTEM FOR AN ENCAPSULATION DEVICE - The present invention provides, in at least one embodiment, a loading device, system and method that loads aggregate cells into an encapsulation device for implanting into a patient. The loading system uses negative pressure from a low pressure pump in a closed system to improve safety and cell viability while allowing for even loading of the encapsulation device. | 12-29-2016 |