Class / Patent application number | Description | Number of patent applications / Date published |
435116000 | Alanine; leucine; isoleucine; serine; homoserine | 27 |
20090123981 | XYLAN-UTILIZATION REGULON FOR EFFICIENT BIOPROCESSING OF HEMICELLULOSE AND USES THEREOF - The subject invention provides at least one nucleic acid sequence encoding an aldouronate-utilization regulon isolated from | 05-14-2009 |
20090170171 | Method of Producing L-Serine Derivative and Enzyme Used Therefore - The present invention provides a new method for producing serine derivatives and their optically-activated derivatives in a convenient manner. In the presence of an enzyme, an L-α-amino acid of formula (I): | 07-02-2009 |
20090253186 | MICROORGANISM PRODUCING L-METHIONINE PRECURSOR AND THE METHOD OF PRODUCING L-METHIONINE PRECURSOR USING THE MICROORGANISM - The present invention relates to a microorganism producing L-methionine precursor, O-acetylhomoserine, and a method of producing L-methionine precursor using the microorganism. | 10-08-2009 |
20090253187 | MICROORGANISM PRODUCING L-METHIONINE PRECURSOR AND THE METHOD OF PRODUCING L-METHIONINE PRECURSOR USING THE MICROORGANISM - The present invention relates to a microorganism producing L-methionine precursor, O-succinylhomoserine, and a method of producing L-methionine precursor using the microorganism, | 10-08-2009 |
20090275092 | METHOD FOR PRODUCING 4-HYDROXY-L-ISOLEUCINE - A highly active L-isoleucine dioxygenase from | 11-05-2009 |
20100028959 | METHOD FOR PRODUCTION OF L-AMINO ACID - The present invention has its object to provide a method for producing an L-amino acid comprising reacting a keto acid with an amino acid dehydrogenase and an enzyme having coenzyme regenerating ability to convert to a L-amino acid, wherein a coenzyme is added in two or more portions in the reaction. The method of the present invention enables efficient production of an L-amino acid useful as a synthetic intermediate such as a pharmaceutical intermediate with high optical purity by an enzymatic reductive amination independent of the purity of the keto acid used as a substrate. | 02-04-2010 |
20100248312 | Alanine 2,3-aminomutases and related polynucleotides - The present disclosure relates generally to polypeptides having improved alanine 2,3-aminomutase (AAM) activity, the polynucleotides encoding the AAM polypeptides, and expression vectors and host cells for expressing the AAM polypeptides. | 09-30-2010 |
20100304450 | MICROBIAL PRODUCTION OF PYRUVATE AND PYRUVATE DERIVATIVES - Microbial production of pyruvate and metabolites derived from pyruvate in cells exhibiting reduced pyruvate dehydrogenase activity compared to wild-type cells. Acetate and glucose are supplied as a carbon sources. | 12-02-2010 |
20100317068 | METHOD FOR PRODUCING SERINE DERIVATIVE AND PROTEIN USED FOR THE SAME - The present invention describes a method for generating a serine derivative and an optically active isomer thereof by a convenient technique, and an enzyme and the like useful in the method. In the presence of the following protein (A) and/or (B) having an enzymatic activity, an α-amino acid is reacted with an aldehyde to form a serine derivative:
| 12-16-2010 |
20100323409 | PROCESS FOR PRODUCING (2S,3R,4S)-4-HYDROXY-L-ISOLEUCINE - A method for manufacturing (2S,3R,4S)-4-hydroxy-L-isoleucine or a salt thereof using an L-isoleucine-producing bacterium transformed with a DNA fragment containing a gene coding for a protein having L-isoleucine dioxygenase activity; and having the ability to produce (2S,3R,4S)-4-hydroxy-L-isoleucine. | 12-23-2010 |
20110124061 | METHOD FOR PREPARATION OF POLYUNSATURATED FATTY ACID-CONTAINING PHOSPHATIDYLSERINE - A method for the preparation of the polyunsaturated fatty acids-containing phosphatidylserine, the method comprising: combining L-serine with a fish liver phosphatidylcholine having a polyunsaturated fatty acid to form a mixture; reacting the mixture with phospholipase D to effect transphosphatidylation of L-serine and the phosphatidylcholine having polyunsaturated fatty acids to produce the polyunsaturated fatty acids-containing phosphatidylserine. | 05-26-2011 |
20110244530 | L-SUCCINYLAMINOACYLASE AND PROCESS FOR PRODUCING L-AMINO ACID USING IT - The present invention provides an L-aminoacylase which is able to produce L-tert-leucine being useful as an intermediate for pharmaceuticals. | 10-06-2011 |
20110250654 | MICROAEROBIC CULTURES FOR CONVERTING GLYCEROL TO CHEMICALS - Glycerol or other reduced carbon sources may be used as a feedstock for the microbial production of chemical products under certain microaerobic conditions. For example, such production may occur under microaerobic or microrespiratory conditions in which electron acceptors are consumed in the reaction as quickly as they are added. In such reactions, the reaction product is at least as reduced as carbon source. Further, during such a reaction, at least some of the carbon source is used to generate cell mass. In addition, microorganisms with modified genomes are provided for carrying out the methods herein. | 10-13-2011 |
20120077233 | DNA ENCODING NOVEL ENZYME HAVING D-SERINE SYNTHASE ACTIVITY, METHOD OF PRODUCING THE ENZYME AND METHOD OF PRODUCING D-SERINE BY USING THE SAME - This invention relates to DNA encoding a novel enzyme having activity of synthesizing D-serine from formaldehyde and glycine, recombinant DNA constructed by integrating such DNA into a vector, a transformant transformed with the recombinant DNA, and a method for producing D-serine from formaldehyde and glycine with the use of the enzyme. | 03-29-2012 |
20120107883 | METHOD FOR PRODUCING 4-HYDROXY-L-ISOLEUCINE - A highly active L-isoleucine dioxygenase from | 05-03-2012 |
20120107884 | METHOD FOR PRODUCING 4-HYDROXY-L-ISOLEUCINE - A highly active L-isoleucine dioxygenase from | 05-03-2012 |
20120219997 | STRAINS OF ESCHERICHIA COLI MODIFIED BY METABOLIC ENGINEERING TO PRODUCE CHEMICAL COMPOUNDS FROM HYDROLYZED LIGNOCELLULOSE, PENTOSES, HEXOSES AND OTHER CARBON SOURCES - The present invention refers to the new | 08-30-2012 |
20120329107 | METHOD FOR PREPARING OPTICALLY ACTIVE AMINO ACIDS AND OPTICALLY ACTIVE AMINO ACID AMIDES - The present invention relates to a method for producing D- or L-tert-leucine or D- or L-tert-leucine amide by reacting DL-tert-leucine amide with a biocatalyst selected from the group consisting of an enzyme capable of hydrolyzing the DL-tert-leucine amide stereoselectively, cells of a microorganism having the enzyme, a material produced by the treatment of the cells, an immobilized enzyme produced by immobilizing the enzyme onto a carrier, immobilized cells produced by immobilizing the cells onto a carrier, and an immobilized cell treatment product obtained by immobilizing the cell treatment product onto a carrier to thereby hydrolyze the DL-tert-leucine amide, wherein the hydrolysis is carried out with separating ammonia produced by the hydrolysis from the hydrolysis reaction solution. According to the present invention, the concentration of an amino acid amide as a raw material in the reaction solution can be enhanced without the need of increasing the amount of the cells or a pH-adjusting acid by maintaining the activity per unit amount of the enzyme, the cells or the cell treatment product and per unit time period at a high level in the enzymatic reaction for hydrolyzing an amino acid amide stereoselectively, and consequently the productivity of optically active tert-leucine or optically active tert-leucine amide can be improved to a great extent without increasing the generation of a waste salt or waste cells. | 12-27-2012 |
20130236934 | RECOMBINANT BACTERIUM FOR L-HOMOSERINE PRODUCTION - The present invention encompasses a recombinant bacterium that is capable of producing L-homoserine and methods of using the bacterium for producing L-homoserine. | 09-12-2013 |
20130273615 | MODIFIED POLYPEPTIDE HAVING HOMOSERINE ACETYLTRANSFERASE ACTIVITY AND MICROORGANISM EXPRESSING THE SAME - The present invention relates to a polypeptide that is modified to have homoserine O-acetyltransferase activity, and in particular, the present invention provides a modified polypeptide having homoserine O-acetyltransferase activity, in which the amino acid at position 111 of a polypeptide having homoserine succinyltransferase activity is substituted with other amino acid. | 10-17-2013 |
20150072382 | CELL WITH REDUCED PPGPPASE ACTIVITY - The present invention relates to a cell which is genetically modified over its wild type in such a way that it has a reduced ppGppase activity relative to its wild type, and preferably an essential amino acid, even more preferably an essential amino acid derived from serine, most preferably methionine or tryptophan, to a feed additive comprising such a cell, to a method of preparing a cell overproducing essential amino acid, more preferably an essential amino acid derived from serine, most preferably methionine or tryptophan, comprising preparing a cell having a knocked-out gene coding for a ppGppase, and to a method of preparing an essential amino acid, more preferably an essential amino acid derived from serine, most preferably methionine or tryptophan, comprising the steps of a) culturing the cell according to the first aspect of the present invention or to any of its embodiments, and b) optionally: purifying the amino acid. | 03-12-2015 |
20150079641 | FEEDBACK-RESISTANT ALPHA-ISOPROPYLMALATE SYNTHASES - The invention relates to an isolated nucleotide sequence encoding an amino acid sequence that is at least ≧90%, ≧92%, ≧94%, ≧96%, ≧97%, ≧98%, ≧99% or 100%, preferably ≧97%, particularly preferably ≧98%, very particularly preferably ≧99%, and extremely preferably 0%, identical to the amino acid sequence of SEQ ID NO:2, wherein SEQ ID NO:2, at position 553, or at a corresponding position of the amino acid sequence, has a proteinogenic amino acid other than L-tyrosine, to a microorganism comprising the nucleotide sequence and also to a process for producing fine chemicals using this microorganism. | 03-19-2015 |
20150087032 | YEAST CELL WITH INCREASED PYRUVATE POOL IN CYTOSOL AND METHOD OF PRODUCING PYRUVATE-BASED METABOLITE USING THE SAME - A genetically engineered yeast cell that produces a pyruvate-based metabolite from pyruvate, wherein activity of a mitochondrial pyruvate carrier (MPC) is reduced compared to a parent yeast cell and a method of producing the pyruvate-based metabolite using the yeast cell. | 03-26-2015 |
20150099282 | NADP-DEPENDENT ALANINE DEHYDROGENASE - The present invention relates to a polypeptide comprising the amino acid sequence of the | 04-09-2015 |
20150376663 | RECOMBINANT MICROORGANISM FOR IMPROVED PRODUCTION OF FINE CHEMICALS - The present invention relates to a recombinant nucleic acid molecule, a recombinant microorganism, to a method for producing alanine and to the use of the recombinant nucleic acid molecule or the recombinant microorganism for the fermentative production of alanine. | 12-31-2015 |
20160046970 | DNA ENCODING NOVEL ENZYME HAVING D-SERINE SYNTHASE ACTIVITY, METHOD OF PRODUCING THE ENZYME AND METHOD OF PRODUCING D-SERINE BY USING THE SAME - This invention relates to DNA encoding a novel enzyme having activity of synthesizing D-serine from formaldehyde and glycine, recombinant DNA constructed by integrating such DNA into a vector, a transformant transformed with the recombinant DNA, and a method for producing D-serine from formaldehyde and glycine with the use of the enzyme. | 02-18-2016 |
20160145699 | L-ISOLEUCINE-PRODUCING MICROORGANISM AND METHOD OF PRODUCING L-ISOLEUCINE USING THE SAME - The present invention relates to a microorganism having an enhanced ability to produce L-isoleucine and a method of producing L-isoleucine using the same. More specifically, the present invention relates to a | 05-26-2016 |