Entries |
Document | Title | Date |
20080199920 | S-Adenosylmethionine-6-N-Lysine-Methyltransferase From Neurospora Crassa, A Gene Encoding The Same, A Vector And Host Cell Containing The Same, And Method For Producing Trimethyllysine Using The Host Cell - Provided is S-adenosylmethionine-6-N-lysine-methyl-transferase obtained from Neνrospora | 08-21-2008 |
20080261279 | METHOD FOR PRODUCING L-AMINO ACID USING BACTERIA BELONGING TO THE GENUS ESCHERICHIA - A method for producing L-threonine, L-valine, L-proline, L-leucine, L-methionine and L-arginine is provided using | 10-23-2008 |
20080268510 | METHOD FOR PRODUCING L-BETA-LYSINE - Purified β-amino acids are of considerable interest in the preparation of pharmacologically active compounds. Although enantiomerically pure β-amino acids, such as L-β-lysine, can be produced by standard chemical synthesis, this traditional approach is time consuming, requires expensive starting materials, and results in a racemic mixture which must be purified further. However, DNA molecules encoding lysine 2,3-aminomutase can be used to prepare L-β-lysine by methods that avoid the pitfalls of chemical synthesis. In particular, L-β-lysine can be synthesized by cultures of host cells that express recombinant lysine 2,3-aminomutase. Alternatively, such recombinant host cells can provide a source for isolating quantities of lysine 2,3-aminomutase, which in turn, can be used to produce L-β-lysine in vitro. | 10-30-2008 |
20080280333 | Use of the repressor glxR for the synthesis of lysine in corynebacterium glutamicum - Isolated polypeptide sequence having the sequence of SEQ ID NO:1 or muteins thereof having the ability to bind cAMP and repress the expression of the aceB gene of | 11-13-2008 |
20080318286 | P1-35 Expression Units - The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms. | 12-25-2008 |
20080318287 | Fermentative Production of Organic Compounds Using Substances Containing Dextrin - A process for the production of at least one organic compound having at least 3 C atoms or having at least 2 C atoms and at least 1N atom by means of fermentation, comprises the following steps:
| 12-25-2008 |
20090017507 | DRY GRANULATED PRODUCT CONTAINING L-LYSINE AS MAIN COMPONENT - Hydrochloric acid, sulfuric acid or an L-lysine solution having an equivalent ratio of anion/L-lysine higher than 0.95 is added to a raw material L-lysine solution having an equivalent ratio of anion/L-lysine lower than 0.68 to adjust the equivalent ratio of anion/L-lysine of the raw material solution to be in the range of 0.68 to 0.95, and the obtained L-lysine solution or a concentrate thereof is granulated and dried to obtain a dry granulated product having a high L-lysine content and showing low caking property and low hygroscopic property. | 01-15-2009 |
20090029425 | PROCESS FOR THE PRODUCTION OF BETA-LYSINE - Process for the production of -lysine by constructing a recombinant microorganism which has a deregulated lysine 2,3-aminomutase gene and at least one deregulated gene selected from the group (i) which consists of aspartokinase, aspartatesemialdehyde dehydrogenase, dihydrodipicolinate synthase, dihydrodipicolinate reductase, tetrahydrodipicolinate succinylase, succinyl-amino-ketopimelate transaminase, succinyl-diamino-pimelate desuccinylase, diaminopimelate epimerase, diamino-pimelate dehydrogenase, arginyl-tRNA synthetase, diaminopimelate decarboxylase, pyruvate carboxylase, phosphoenolpyruvate carboxylase, glucose-6-phosphate dehydrogenase, transketolase, transaldolase, 6-phosphogluconolactonase, fructose 1,6-biphosphatase, homoserine dehydrogenase, phophoenolpyruvate carboxykinase, succinyl-CoA synthetase, methylmalonyl-CoA mutase, provided that if aspartokinase is deregulated as gene (i) at least a second gene (i) other than aspartokinase has to be deregulated, and cultivating said microorganism. | 01-29-2009 |
20090053779 | MUTANT MICROORGANISM HAVING IMPROVED PRODUCTION ABILITY OF BRANCHED AMINO ACID AND METHOD FOR PREPARING BRANCHED AMINO ACID USING THE SAME - The present invention relates to mutant microorganisms having improved productivity of branched-chain amino acids, and a method for producing branched-chain amino acids using the mutant microorganisms. More specifically, relates to mutant microorganisms having improved productivity of L-valine, which are produced by attenuating or deleting a gene encoding an enzyme involved in L-isoleucine biosynthesis, a gene encoding an enzyme involved in L-leucine, and a gene encoding an enzyme involved in D-pantothenic acid biosynthesis, and mutating a gene encoding an enzyme involved in L-valine biosynthesis, such that the expression thereof is increased, as well as a method for producing L-valine using the mutant microorganisms. The inventive mutant microorganisms produced by site-specific mutagenesis and metabolic pathway engineering can produce branched-chain amino acids, particularly L-valine, with high efficiency, and thus will be useful as industrial microorganisms for producing L-valine. | 02-26-2009 |
20090075348 | Method for Recovering a Basic Amino Acid from a Fermentation Liquor - The invention relates to a method for recovering a basic amino acid from the fermentation liquor of a micro-organism strain that produces the basic amino acid. The method comprises the following steps: a) isolation of the micro-organisms from the fermentation liquor and b) separation of the basic amino acid from the aqueous liquor that has been obtained in step a) by the successive charging of a single or multiple stage arrangement of a strongly acidic cation exchanger in the form of a salt with the liquor obtained in step a) and the elution of the basic amino acid. According to the invention, prior to the charging process in step b), the aqueous liquor has a pH value ranging between 4 and 7.5 and at least the first stage of the carbon exchanger arrangement is pre-treated with an aqueous acid in such a way that at the end of said pre-treatment, the pH value at the discharge of the pre-treated cation exchanger ranges between 4.5 and 7. | 03-19-2009 |
20090081740 | PRODUCTION OF AMINO ACIDS FROM SUCROSE IN CORYNEBACTERIUM GLUTAMICUM - Methods and compositions for increased production of amino acids from | 03-26-2009 |
20090093030 | fadR KNOCK-OUT MICROORGANISM AND METHODS FOR PRODUCING L-THREONINE - The present invention relates to an L-threonine-producing chromosomal fadR gene knock-out microorganism. The present invention further relates to a method for producing L-threonine using a fadR knock-out microorganism. Mutated microorganisms of the present invention are capable of increased L-threonine production. | 04-09-2009 |
20090117624 | Process for the fermentative preparation of organic chemical compounds using coryneform bacteria in which the SugR gene is present in attenuated form - The invention relates to a recombinant coryneform bacterium which secretes an organic chemical compound and in which the sugR gene which codes for a polypeptide having the activity of an SugR regulator has been attenuated. The invention further relates to a processes for using this bacterium for the fermentative preparation of organic chemical compounds. | 05-07-2009 |
20090142814 | METHOD FOR PRODUCING CARBOXYLIC ACID USING METHANOL-ASSIMILATING BACTERIUM - A method for producing a carboxylic acid by a fermentation process which comprises culturing a methanol-assimilating bacterium capable of producing the carboxylic acid in a liquid medium containing methanol and a counter ion to produce and accumulate the carboxylic acid in the medium, further comprising the feeding of a substance comprising methanol and a counter ion to the medium by fed-batch culturing to maintain the total ionic strength within the fermentation medium at or below a certain level. | 06-04-2009 |
20090148915 | Method for Producing L-Lysine or L-Threonine - A bacterium belonging to the genus | 06-11-2009 |
20090155861 | METHOD FOR PRODUCING AN L-AMINO ACID USING A BACTERIUM OF THE ENTEROBACTERIACEAE FAMILY - A method is described for producing an L-amino acid, for example L-threonine, L-lysine, L-leucine, L-histidine, L-cysteine, L-phenylalanine, L-arginine, L-tryptophan, L-glutamic acid, L-valine, and L-isoleucine, by fermentation of glucose using a bacterium of the Enterobacteriaceae family, wherein the bacterium has been modified to enhance the activity of the high-affinity arabinose transporter coded by the araFGH operon. | 06-18-2009 |
20090162908 | METHOD FOR PRODUCING AN L-AMINO ACID USING A BACTERIUM OF THE ENTEROBACTERIACEAE FAMILY - The present invention provides a method for producing an L-amino acid from ethanol using a bacterium of the Enterobacteriaceae family, wherein the bacterium has been modified to enhance the expression of the ydbK gene. | 06-25-2009 |
20090186389 | MICROORGANISM WHOSE ACTIVITY OF ASPARTATE SEMIALDEHYDE DEHYDROGENASE IS ENHANCED AND THE PROCESS FOR PRODUCING L-THREONINE USING THE MICROORGANISM - The present invention relates to a microorganism producing L-threonine with increased L-threonine production efficiency by the increased activity of aspartate semialdehyde dehydrogenase in L-threonine biosynthesis pathway, | 07-23-2009 |
20090197309 | Mutant Acetolactate Synthase and a Method for Producing Branched-Chain L-Amino Acids - A mutant bacterial acetolactate synthase (AHAS I) which is resistant to feedback inhibition by L-valine is described. Also described is a method for producing branched-chain L-amino acids using a bacterium from the Enterobacteriaceae family wherein the L-amino acid productivity of said bacterium is enhanced by the use of the acetolactate synthase (AHAS I) which is resistant to feedback inhibition by L-valine. This acetolactate synthase contains a mutant small subunit encoded by the mutant ilvN gene. | 08-06-2009 |
20090209012 | Method for producing l-amino acids - Disclosed is a process for producing the L-form of an amino acid enzymatically from an enantiomeric mixture of the amino acid. The process includes the step of contacting a transformant or a treated product thereof with an enantiomeric mixture of the amino acid. The transformant includes a single host and one or more recombinant vectors introduced thereinto, in which the one or more recombinant vectors include one or more expression vectors and nucleotide sequences integrated thereinto respectively, and the nucleotide sequences are a nucleotide sequence encoding an enzyme capable of converting the D-form of an amino acid into a keto acid and a nucleotide sequence encoding an enzyme capable of converting a keto acid into the L-form of an amino acid. According to this process, a reaction for converting the D-form of an amino acid into a keto acid and a reaction for converting the keto acid into the L-form of the amino acid can be conducted in a single step. Disclosed also is a transformant capable of converting into the L-form of an amino acid as accumulated in a high concentration. The L-form of an amino acid can be efficiently produced from an inexpensive starting material by using the transformant. | 08-20-2009 |
20090215132 | Novel amide hydrolase gene - The present invention relates to an amide hydrolase which is with excellent thermostability and stereoselectively hydrolyzes an α-amino acid amide; a gene encoding the enzyme protein; a novel recombinant vector containing the gene; a transformant containing the recombinant vector; and a process for producing an L-α-amino acid using the transformant. | 08-27-2009 |
20090215133 | PRODUCTION OF L-LYSINE AND L-LYSINE-CONTAINING FEED ADDITIVES - The invention relates to a process for producing L-lysine or L-lysine-containing feed additives by fermentation, which comprises
| 08-27-2009 |
20090239270 | Compositions And Methods For Producing Fermentation Products And Residuals - The present invention provides compositions and methods designed to increase value output of a fermentation reaction. In particular, the present invention provides a business method of increasing value output of a fermentation plant. The present invention also provides a modified fermentation residual of higher commercial value. Also provided in the present invention are complete animal feeds, nutritional supplements comprising the subject ferment residuals. Further provided by the present invention is a method of performing fermentation, a modified fermentative microorganism and a genetic vehicle for modifying such microorganism. | 09-24-2009 |
20090280542 | METHOD OF PRODUCTION OF L-AMINO ACIDS - An isolated polynucleotide encodes a polypeptide comprising the amino acid sequence of SEQ ID NO: 2, with the L-aspartic acid at position 5 of the amino acid sequence replaced by another proteinogenic amino acid, and possesses citrate synthase activity. In addition, a vector comprises the polynucleotide and a bacterium comprises the vector. An isolated polynucleotide comprises a nucleotide sequence comprising, from position 1 to 39, the nucleotide sequence corresponding to position 1 to 39 of SEQ ID NO: 11, from position 40 to 105, a nucleotide sequence encoding the amino acid sequence of SEQ ID NO: 12, with each proteinogenic amino acid except L-aspartic acid being present at position 5. A method of producing an L-amino acids is also described. | 11-12-2009 |
20090298138 | MICROORGANISM PRODUCING L-THREONINE HAVING AN INACTIVATED LYSR GENE, METHOD FOR PRODUCING THE SAME AND METHOD FOR PRODUCING L-THREONINE USING THE MICROORGANISM - Provided are a microorganism having an inactivated lysR gene in its chromosome and can produce L-threonine, a method of producing the microorganism, and a method d of producing L-threonine using the method. The microorganism can produce L-threonine with a high yield. | 12-03-2009 |
20090305363 | ENHANCED PYRUVATE TO ACETOLACTATE CONVERSION IN YEAST - A high flux in conversion of pyruvate to acetolactate was achieved in yeast through expression of acetolactate synthase in the cytosol in conjunction with reduction in pyruvate decarboxylase activity. Additional manipulations to improve flux to acetolactate are reduced pyruvate dehydrogenase activity and reduced glycerol-3-phosphate dehydrogenase activity. Production of compounds having acetolactate as an upstream intermediate benefit from the increased conversion of pruvate to acetolactate in the described strains. | 12-10-2009 |
20090311758 | PROCESS FOR PREPARING L-AMINO ACIDS - A process for preparing L-amino acids employing coryneform bacteria in which the AmtR regulator has been attenuated is provided. Recombinant bacteria, polynucleotides and vectors corresponding to or having the attenuated AmtR regulator are disclosed. | 12-17-2009 |
20100015673 | Microorganism Of Corynebacterium Genus Having Enhanced L-Lysine Productivity And A Method Of Producing L-Lysine Using The Same - The present invention relates to a microorganism of | 01-21-2010 |
20100015674 | Methods For The Preparation of Lysine By Fermentation Of Corynebacterium Glutamicum - The present invention features methods of increasing the production of a fine chemical, e.g., lysine from a microorganism, e.g., | 01-21-2010 |
20100028957 | Microorganism Of Corynebacterium Genus Having Enhanced L-Lysine Productivity And A Method Of Producing L-Lysine Using The Same - The present invention relates to a microorganism of | 02-04-2010 |
20100028958 | METHOD FOR PRODUCTION OF L-AMINO ACID - A method for producing an L-amino acid is described, which is characterized by culturing a | 02-04-2010 |
20100035308 | METHOD OF PREPARING A CONTROLLED RELEASE FERTILIZER - Methods of preparing a controlled release fertilizer include obtaining an amino acid fermentation byproduct liquor, and converting ammonium in the amino acid fermentation byproduct liquor to magnesium ammonium phosphate to obtain the controlled release fertilizer. | 02-11-2010 |
20100047882 | METHOD OF RECOVERING L-THREONINE FROM L-THREONINE FERMENTATION BROTH USING NONSOLVENT - Provided are a method of recovering L-threonine from the fermentation broth of an L-threonine producing microorganism, comprising: separating microbial bodies from the L-threonine containing fermentation broth obtained by culturing an L-threonine producing microorganism and filtering the separated fermentation broth to obtain a filtrate; concentrating the filtrate; and reacting the concentrated filtrate with a nonsolvent to obtain crystalline L-threonine, crystalline L-threonine recovered by the method, and a feed additive containing the crystalline L-threonine recovered by the method. | 02-25-2010 |
20100143984 | CORYNEBACTERIA HAVING ENHANCED L-LYSINE PRODUCTIVITY AND A METHOD OF PRODUCING L-LYSINE USING THE SAME - A variant of | 06-10-2010 |
20100173368 | METHOD FOR PRODUCING L-LYSINE | 07-08-2010 |
20100190216 | METHOD FOR PRODUCTION OF L-LYSINE USING METHANOL-UTILIZING BACTERIUM - A method for production of L-lysine is provided which includes the steps of cultivating a methanol-utilizing bacterium in a culture medium to produce and accumulate L-lysine in the culture medium and collecting the L-lysine from the culture medium, wherein the methanol-utilizing bacterium contains DNA encoding dihydrodipicolinate synthetase which is desensitized to feedback inhibition by L-lysine and DNA encoding a LysE protein that can enhance the excretion of L-lysine out of the methanol-utilizing bacterium, and the bacterium is modified so as to increase the intracellular activities of diaminopimelic acid dehydrogenase, diaminopimelic acid decarboxylase, dihydrodipicolinic acid reductase and aspartate-semialdehyde dehydrogenase. | 07-29-2010 |
20100190217 | METHOD FOR PRODUCING L-LYSINE - L-Lysine is produced by culturing in a medium an | 07-29-2010 |
20100261233 | L-LYSINE-PRODUCING CORYNEBACTERIA AND PROCESS FOR THE PREPARATION OF L-LYSINE - L-lysine-producing strains of | 10-14-2010 |
20100267095 | ESCHERICHIA COLI STRAINS WHICH OVER-PRODUCE L-THREONINE AND PROCESSES FOR THE PRODUCTION OF L-THREONINE BY FERMENTATION - The present invention relates to the fields of microbiology and microbial genetics. More specifically, the invention relates to novel bacteria strains and processes employing these strains for the fermentative production of amino acids such as threonine. | 10-21-2010 |
20100273222 | CORYNEBACTERIUM GLUTAMICUM ENHANCED EXPRESSION OF MOAA GENE ENCODING MOLYBDENUM COFACTOR BIOSYNTHESIS ENZYME A AND METHOD FOR PRODUCING L-LYSINE USING THE SAME - The present invention relates to a microorganism of | 10-28-2010 |
20100317067 | PROMOTER AND A PRODUCTION METHOD FOR L-LYSINE USING THE SAME - Disclosed are a nucleic acid molecule of | 12-16-2010 |
20100330624 | Vector for transformation using transposons, microorganisms transformed by the vector, and method for producing L-lysine using the same - The present invention relates to a vector for transformation using transposon genes, microorganisms transformed by the vector, and a method for producing L-lysine using the microorganisms. | 12-30-2010 |
20110003349 | L-Threonine Overproducing Microorganism and Method for Preparing L-Threonine Using the Same - The present invention relates to a mutant microorganism producing a high concentration of L-threonine in high yield, prepared using site-specific mutation, not random mutation, such as treatment with a mutation inducer, a method for preparing the same, and a method for preparing L-threonine using the mutant microorganism producing L-threonine. By using the mutant microorganism according to the present invention, L-threonine can be prepared at high yield, additional strain development becomes possible and their physiological phenomena can be easily understood since genetic information of L-threonine producing microorganism can be identified. | 01-06-2011 |
20110045549 | POLYNUCLEOTIDES ENCODING A FEEDBACK RESISTANT ASPARTOKINASE FROM CORYNEBACTERIUM - The invention provides methods to increase the production of an amino acid from | 02-24-2011 |
20110065153 | METHOD OF PRODUCING L-LYSINE - The ability and speed with which a coryneform bacterium can produce L-lysine are improved when the coryneform bacterium contains an aspartokinase in which feedback inhibition by L-lysine and L-threonine is substantially desensitized. This is accomplished by successively enhancing the DNA coding for dihydrodipicolinate reductase, the DNA coding for dihydrodipicolinate synthase, the DNA coding for diaminopimelate decarboxylase, and the DNA coding for diaminopimelate dehydrogenase. | 03-17-2011 |
20110076731 | PROMOTER, AND A PRODUCTION METHOD FOR L-LYSINE USING THE SAME - Disclosed are a nucleic acid molecule of | 03-31-2011 |
20110124060 | YEAST PRODUCTION HOST CELLS - Crabtree positive yeast cells that have endogenous expressed pyruvate decarboxylase genes inactivated and an engineered biosynthetic pathway utilizing pyruvate were found to have improved growth and product yield when glucose repression was reduced. These cells were able to grow in media containing a high glucose concentration. | 05-26-2011 |
20110129882 | GENE CODING FOR GLUCOSE-6-PHOSPHATE-DEHYDROGENASE PROTEINS - The present invention relates to isolated nucleic acid molecules encoding mutants of glucose-6-phosphate dehydrogenase, and vectors and hosts cells including such nucleic acid molecules. These nucleic acid molecules are involved in the biosynthesis of a fine chemical, e.g., an amino acid such as lysine. The present invention also relates to methods of producing and modulating the production of fine chemicals, e.g., lysine, by culturing recombinant microorganisms containing these nucleic acid molecules under conditions such that the fine chemical is produced. | 06-02-2011 |
20110143403 | METHOD FOR PRODUCING L-AMINO ACIDS USING BACTERIA OF THE ENTEROBACTERIACEAE FAMILY - There is disclosed a method for producing L-amino acid, for example L-threonine, L-lysine, L-histidine, L-phenylalanine, L-arginine or L-glutamic acid, using a bacterium of the Enterobacteriaceae family, wherein the bacterium has been modified to enhance an activity of D-xylose permease. | 06-16-2011 |
20110177568 | Method of L-Lysine Production - The present invention relates to a method of microbial production of L-lysine from methanol and other substrates, and particularly improving the production of L-lysine from such substrates. The invention concerns a method for producing lysine in | 07-21-2011 |
20110189739 | ESCHERICHIA COLI STRAIN WITH ENHANCED L-THREONINE PRODUCTIVITY AND METHOD OF PRODUCING L-THREONINE USING THE SAME - An L-threonine-producing | 08-04-2011 |
20110217741 | Enhanced Promoter and Method for Producing L-Lysine Using the Same - The present invention provides a nucleic acid molecule having enhanced promoter activity, which is operably linked to a gene encoding aspartate aminotransferase and derived from | 09-08-2011 |
20120040415 | METHOD FOR PRODUCING AN L-AMINO ACID - A method is provided for producing an L-amino acid which includes the steps of culturing a bacterium, which belongs to the family Enterobacteriaceae and is able to produce an L-amino acid, in a medium containing glycerol as a carbon source to produce and accumulate an L-amino acid in the medium, and collecting the L-amino acid from the culture. The culture is performed as a fed-batch culture or a continuous culture, and a feed medium containing glycerol is added to the fermentation medium so that the glycerol concentration in the fermentation medium is 5 g/L or higher. | 02-16-2012 |
20120070865 | METHOD FOR PRODUCING AN L-AMINO ACID USING BACTERIUM OF THE ENTEROBACTERIACEAE FAMILY WITH ATTENUATED EXPRESSION OF A GENE CODING FOR SMALL RNA - The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus | 03-22-2012 |
20120107882 | Recombinant Microorganism And Method For Producing L-Lysine - The present invention provides methods of producing L-lysine at a high yield using an | 05-03-2012 |
20120122163 | Microorganism Which Produces L-Amino Acid and Method for Producing L-Amino Acid Using the Same - The present invention relates to a microorganism belonging to the genus | 05-17-2012 |
20120156735 | RECOMBINANT HOST CELLS COMPRISING PHOSPHOKETOLASES - The present invention is related to recombinant host cells comprising: (i) at least one deletion, mutation, and/or substitution in an endogenous gene encoding a polypeptide that converts pyruvate to acetaldehyde, acetyl-phosphate or acetyl-CoA; and (ii) a heterologous polynucleotide encoding a polypeptide having phosphoketolase activity. The present invention is also related to recombinant host cells further comprising (iii) a heterologous polynucleotide encoding a polypeptide having phosphotransacetylase activity. | 06-21-2012 |
20120156736 | METHOD FOR PRODUCING L-LYSINE USING A VIBRIO BACTERIUM - L-Lysine is produced by culturing in a medium a | 06-21-2012 |
20120208245 | METHOD FOR PRODUCING L-LYSINE USING CORYNEBACTERIUM SP. THAT HAS OBTAINED THE ACTIVITY OF GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE DERIVED FROM AN ALIEN SPECIES - The present invention relates to a | 08-16-2012 |
20120214211 | Process for the Fermentative Preparation of Organic Chemical Compounds Using Coryneform Bacteria in which the SugR Gene is Present in Attenuated Form - The invention relates to a recombinant coryneform bacterium which secretes an organic chemical compound and in which the sugR gene which codes for a polypeptide having the activity of an SugR regulator has been attenuated. The invention further relates to a processes for using this bacterium for the fermentative preparation of organic chemical compounds. | 08-23-2012 |
20120219996 | METHOD FOR PRODUCING L-AMINO ACIDS USING BACTERIA OF THE ENTEROBACTERIACEAE FAMILY - There is disclosed a method for producing L-amino acid, for example L-threonine, L-lysine, L-histidine, L-phenylalanine, L-arginine or L-glutamic acid, using a bacterium of the Enterobacteriaceae family, wherein the bacterium has been modified to enhance an activity of D-xylose permease. | 08-30-2012 |
20120252078 | Microorganism Which Produces L-Amino Acid and Method for Producing L-Amino Acid Using the Same - The present invention relates to a microorganism belonging to the genus | 10-04-2012 |
20120276598 | METHOD FOR PRODUCING AN L-AMINO ACID - A method for efficiently producing an L-amino acid, especially L-lysine, by using a γ-proteobacterium is provided. In a method for producing an L-amino acid comprising culturing a bacterium belonging to γ-Proteobacteria and having an ability to produce an L-amino acid, for example, an Enterobacteriaceae bacterium such as | 11-01-2012 |
20130011885 | PROCESS FOR FRACTIONATION OF LIGNOCELLULOSIC BIOMASS - Methods are provided for the efficient fractionation of lignocellulosic biomasses into cellulosic, hemicellulosic and lignin fractions, wherein concentrated organic acid vapors are applied to the biomass at elevated temperatures at the location(s) or near the location(s) where the biomass has been harvested and gathered, to at least partly depolymerize or substantially solubilize the hemicelluloses and lignins in the biomass. The organic acid-treated biomass is in either case then dried and pelletized for extended bulk storage and/or for shipment to a second facility some distance away. The organic acid-treated biomass may be processed into desired chemicals, fuels and/or fuel additives at the local processing site or at a second facility away from the local processing site, or the pelletized material may be used as a ruminant feed locally or at a feedlot some distance removed from the local processing site. | 01-10-2013 |
20130040347 | ESCHERICHIA COLI STRAIN WITH ENHANCED L-THREONINE PRODUCTIVITY AND METHOD OF PRODUCING L-THREONINE USING THE SAME - An L-threonine-producing | 02-14-2013 |
20130045511 | MICROORGANISM HAVING ENHANCED L-VALINE PRODUCTIVITY AND METHOD FOR PRODUCING L-VALINE USING THE SAME - The present invention relates to a microorganism having an enhanced L-valine productivity and a method for producing L-valine using the same. More particularly, the present invention relates to a | 02-21-2013 |
20130045512 | MICROBIAL PRODUCTION OF PYRUVATE AND OTHER METABILITES - Microbial production of pyruvate and metabolites derived from pyruvate in cells exhibiting reduced pyruvate dehydrogenase activity compared to wild-type cells. Acetate and glucose are supplied as a carbon sources. | 02-21-2013 |
20130102037 | Microorganism with Enhanced L-Lysine Productivity and Method for Producing L-Lysine Using the Same - Disclosed is an L-lysine-producing microorganism having gluconate kinase activity weakened in comparison to the endogenous activity thereof, and methods provided for preparing the microorganism and for producing L-lysine using the same. | 04-25-2013 |
20130130331 | METHOD OF PRODUCING SUGARS USING A COMBINATION OF ACIDS TO SELECTIVELY HYDROLYZE HEMICELLULOSIC AND CELLULOSIC MATERIALS - A method is provided for producing sugars using a combination of acids to hydrolyze hemicellulosic and cellulosic materials in biomass, said combination of acids namely comprising a first, weak organic acid (such as acetic acid or formic acid) for providing a pentose product or stream from hydrolyzing hemicellulosic materials in the biomass on a batchwise, semi-continuous or continuous basis, and a second, strong mineral acid (such as sulfuric acid) for providing a hexose product or stream from hydrolyzing cellulosic materials in the biomass. | 05-23-2013 |
20130171700 | L-Amino Acid-Producing Bacterium and Method for Producing L-Amino Acid - An L-amino acid is produced by culturing a | 07-04-2013 |
20130203130 | PRODUCTION PROCESS FOR AMINO ACIDS OF THE ASPARTATE FAMILY USING MICROORGANISMS - The present invention is directed to a method utilizing a recombinant microorganism for the production of aspartate derived amino acids and precursors thereof, in particular for the production of L-lysine. Furthermore, the present invention relates to a recombinant microorganism having improved aspartate-derived amino acid synthesis activity in comparison to the initial microorganism and the use of such microorganisms in producing said amino acids and precursors and derivatives, in particular in the synthesis of L-lysine. | 08-08-2013 |
20130260425 | Method for Producing an L-Amino Acid - A method for producing an L-amino acid includes culturing a bacterium which belongs to the family Enterobacteriaceae and has an L-amino acid-producing ability in a medium containing a carbon source selected from a fatty acid and an alcohol, and collecting the L-amino acid from the medium. A bacterium which has been subjected to a modification including at least one of enhancement of oxyS gene expression, enhancement of fixABC gene expression, and combination thereof, is used as the bacterium, or a substance that reduces intracellular hydrogen peroxide concentration of the bacterium is added to the medium. | 10-03-2013 |
20130266993 | Method for Producing Carboxylic Acid Using Methanol-Assimilating Bacterium - A method for producing a carboxylic acid by a fermentation process which comprises culturing a methanol-assimilating bacterium capable of producing the carboxylic acid in a liquid medium containing methanol and a counter ion to produce and accumulate the carboxylic acid in the medium, further comprising the feeding of a substance comprising methanol and a counter ion to the medium by fed-batch culturing to maintain the total ionic strength within the fermentation medium at or below a certain level. | 10-10-2013 |
20130280767 | HOLLOW FIBER MEMBRANE MODULE AND METHOD FOR PRODUCING CHEMICAL SUBSTANCE - A hollow fiber membrane module includes a housing, a hollow fiber membrane sealed in the housing and a sealing agent in a space between the hollow fiber membrane and the housing, wherein 1) the hollow fiber membrane is made of a polysulfone based resin; 2) a membrane surface average pore diameter is 5 nm or more and 500 nm or less; 3) a pure water permeability coefficient under 50 kPa at 25° C. is 0.05 m | 10-24-2013 |
20140045228 | Method for Producing L-Amino Acid - An L-amino acid is produced by culturing an Enterobacteriaceae which is able to produce an L-amino acid in a medium containing glycerol, especially crude glycerol, as the carbon source to produce and accumulate the L-amino acid in the culture, and collecting the L-amino acid from the culture. | 02-13-2014 |
20140051133 | KETOL-ACID REDUCTOISOMERASE ENZYMES AND METHODS OF USE - Provided herein are polypeptides having ketol-aid reductoisomerase activity as well as microbial host cells comprising such polypeptides. Polypeptides provided herein may be used in biosynthetic pathways, including, but not limited to, isobutanol biosynthetic pathways. | 02-20-2014 |
20140315262 | PROCESS FOR MAKING HMF AND HMF DERIVATIVES FROM SUGARS, WITH RECOVERY OF UNREACTED SUGARS SUITABLE FOR DIRECT FERMENTATION TO ETHANOL - Hydroxymethylfurfural is made from an aqueous hexose sugar solution, especially from a high fructose corn syrup product. By rapidly heating the sugar solution to the elevated temperatures involved as well as rapidly cooling the resultant product mixture, a limited per-pass conversion to HMF is obtained; correspondingly, however, the overall exposure of the HMF that is formed to acidic, elevated temperature conditions is also limited, so that byproducts are reduced. Separation and recovery of the products is simplified, and levels of HMF and other hexose dehydration products known to inhibit ethanol production by fermentation are reduced in the residual sugars product, to an extent whereby the residual sugars product is suited to be directly fermented to ethanol or for other uses. | 10-23-2014 |
20140322766 | C1-C2 Organic Acid Treatment of Lignocellulosic Biomass to Produce Acylated Cellulose Pulp, Hemicellulose, Lignin and Sugars and Fermentation of the Sugars - A process for production of C5 and C6 sugar enriched syrups from lignocellulosic biomass and fermentation products therefrom is described. A lignocellulosic biomass is treated with a C | 10-30-2014 |
20140335574 | Mutant Acetolactate Synthase and a Method for Producing Branched-Chain L-Amino Acids - A mutant bacterial acetolactate synthase (AHAS I) which is resistant to feedback inhibition by L-valine is described. Also described is a method for producing branched-chain L-amino acids using a bacterium from the Enterobacteriaceae family wherein the L-amino acid productivity of said bacterium is enhanced by the use of the acetolactate synthase (AHAS I) which is resistant to feedback inhibition by L-valine. This acetolactate synthase contains a mutant small subunit encoded by the mutant ilvN gene. | 11-13-2014 |
20140349349 | RECOMBINANT HOST CELLS COMPRISING PHOSPHOKETOLASES - The present invention is related to recombinant host cells comprising: (i) at least one deletion, mutation, and/or substitution in an endogenous gene encoding a polypeptide that converts pyruvate to acetaldehyde, acetyl-phosphate, or acetyl-CoA; and (ii) a heterologous polynucleotide encoding a polypeptide having phosphoketolase activity. The present invention is also related to recombinant host cells further comprising (iii) a heterologous polynucleotide encoding a polypeptide having phosphotransacetylase activity. | 11-27-2014 |
20140356916 | PROCESSES AND RECOMBINANT MICROORGANISMS FOR THE PRODUCTION OF FINE CHEMICALS - Recombinant microorganisms with deregulated succinyl-CoA synthetase activity, as well as the uses for producing lysine, β-lysine, cadaverine or N-acetylcadaverine thereby are provided. Recombinant polypeptides comprising an amino acid sequence being at least 80% identical to SEQ ID NO: 51 or 53 are also provided. The method of producing fine chemicals using said recombinant microorganisms, in particular the method of producing lysine, or derivatives thereof, such as β-lysine, cadaverine or N-acetylcadaverine is further provided. | 12-04-2014 |
20140377816 | MICROORGANISMS OF CORYNEBACTERIUM WHICH CAN UTILIZE XYLOSE AND METHOD FOR PRODUCING L-LYSINE USING SAME - The present invention relates to microorganisms of | 12-25-2014 |
20150017693 | Auto-Indicible Expression System, and the Use Thereof for Producing Useful Metabolites Using a Bacterium of the Family Enterobacteriaceae - The present invention describes a method for producing a useful metabolite using a bacterium of the family Enterobacteriaceae, particularly a bacterium belonging to the genus | 01-15-2015 |
20150099281 | METHOD FOR PRODUCING L-LYSINE USING MICROORGANISMS HAVING ABILITY TO PRODUCE L-LYSINE - The present invention relates to a modified polynucleotide encoding aspartate kinase (EC:2.7.2.4; hereinafter, referred to as LysC), transketolase (EC:2.2.1.1; hereinafter, referred to as Tkt) or pyruvate carboxylase (EC:6.4.1.1; hereinafter, referred to as Pyc), in which the initiation codon is substituted with ATG, a vector including the same, a microorganism transformed with the vector, and a method for producing L-lysine using the same. | 04-09-2015 |
20150104836 | METHOD OF PRODUCING L-AMINO ACIDS - Provided is a method of producing | 04-16-2015 |
20150104837 | GENES ENCODING BIOFILM FORMATION INHIBITORY PROTEINS AND A METHOD FOR PRODUCING L-LYSINE USING A BACTERIAL STRAIN WITH THE INACTIVATED GENES - The present invention relates to a novel isolated gene (polynucleotide) which encodes a protein having a biofilm formation inhibitory activity derived from | 04-16-2015 |
20150111261 | L-THREONINE-PRODUCING ESCHERICHIA COLI AND METHOD FOR PRODUCING L-THREONINE USING THE SAME - An L-threonine-producing | 04-23-2015 |
20150315615 | BATCH FEED PROCESS FOR FERMENTING SUGARS - A batch fermentation process ferments a starch hydrolysate containing 80-98 weight percent of glucose based on total carbohydrate and 0.3-5% weight percent of isomaltose based on total carbohydrate to a fermentation product. A fermentation broth is formed containing a first portion of a total amount of the starch hydrolysate so that the fermentation broth has an initial glucose concentration of at least about 50 g/L. Fermentation is carried out until the fermentation broth contains 30 g/L or less of glucose. An effective amount of at least one active enzyme that converts isomaltose into glucose is adding to the fermentation broth. Then the remaining portion of the total amount of starch hydrolysate is fed into the fermentation broth to maintain a glucose concentration of from about 5 to about 15 g/L in the fermentation broth throughout the feeding step. The final fermentation broth containing the fermentation product is then produced. | 11-05-2015 |
20150317458 | IN SILICO PREDICTION OF ENHANCED NUTRIENT CONTENT IN PLANTS BY METABOLIC MODELLING - The present invention relates to a method for identifying at least one metabolic conversion step, the modulation of which increases the amount of a metabolite of interest in a plant cell, plant or plant part, said method comprising establishing a stoichiometric network model for the metabolism of the plant cell, plant or plant part including the synthesis pathway for the metabolite of interest, identifying at least one candidate metabolic conversion step by applying at least one algorithm of Growth-coupled Design, and validating the at least one candidate metabolic conversion step by a constraint-based modeling approach in the stoichiometric network model, wherein an increase in the metabolite of interest occurring in said constraint-based modeling approach is indicative for a metabolic conversion step, the modulation of which increases the amount of the metabolite of interest in the plant cell, plant or plant part. The present invention further relates to a method for generating a plant cell, plant or plant part which produces an increased amount of a metabolite of interest when compared to a control, said method comprising identifying a metabolic conversion step, the modulation of which increases a metabolite of interest in a plant cell, plant or plant part, by the method for identifying a metabolic conversion step and modulating the said metabolic conversion step such that the amount of the metabolite of interest is increased in vivo in a plant cell, plant or plant part. | 11-05-2015 |
20160002684 | Method for Producing L-Lysine by Modifying Aconitase Gene and/or Regulatory Elements thereof - A method for producing L-lysine by fermentation comprises the steps of modifying an aconitase gene and/or regulatory element thereof in a chromosome of a bacterium so that the activity and/or the expression amount of the aconitase of the bacterium are reduced but not eliminated; and producing L-lysine by the fermentation of the modified bacterium. In addition, also provided are methods and uses derived from the method as well as bacteria used in these methods and uses. | 01-07-2016 |
20160032255 | Ketol-Acid Reductoisomerase Enzymes and Methods of Use - Provided herein are polypeptides having ketol-acid reductoisomerase activity as well as microbial host cells comprising such polypeptides. Polypeptides provided herein may be used in biosynthetic pathways, including, but not limited to, isobutanol biosynthetic pathways. | 02-04-2016 |
20160040200 | MICROORGANISMS OF CORYNEBACTERIUM WHICH CAN UTILIZE XYLOSE AND METHOD FOR PRODUCING L-LYSINE USING SAME - The present invention relates to microorganisms of | 02-11-2016 |
20160108444 | Strain having enhanced L-valine productivity and L-valine production method using the same - The present invention relates to a novel L-valine-producing strain which is transformed so as to strengthen the expression of L-valine operon by having a nucleotide sequence, for coding a leader peptide in a regulatory region of ilvBN operon, entirely deleted, or partially deleted or substituted. In addition, the present invention relates to a method for producing L-valine using the novel L-valine-producing strain. According to the novel valine-producing strain and the L-valine production method of the present invention using the strain, there is an advantageous effect of producing L-valine at high efficiency and high yield. | 04-21-2016 |
20160115506 | METHOD FOR PRODUCING L-LEUCINE, L-VALINE, L-ISOLEUCINE, ALPHA-KETOISOVALERATE, ALPHA-KETO-BETA-METHYLVALERATE, OR ALPHA-KETOISOCAPROATE USING RECOMBINANT CORYNEBACTERIA THAT CONTAIN THE ILVBN OPERON WHICH CAN BE INDUCED BY PROPIONATE - The invention relates to a process for the production of amino acids and keto acids using microorganisms, in which a promoter inducible by propionate makes possible the regulated expression of certain genes. | 04-28-2016 |
20160251687 | MICROORGANISM OF CORYNEBACTERIUM SP. HAVING ENHANCED L-LYSINE PRODUCIBILITY AND METHOD FOR PRODUCING L-LYSINE USING SAME | 09-01-2016 |