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Using a micro-organism to make a protein or polypeptide

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435 - Chemistry: molecular biology and microbiology


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Class / Patent application numberDescriptionNumber of patent applications / Date published
435710200 Procaryotic micro-organism 30
20100120094FACTOR VIII POLYPEPTIDE TITERS IN CELL CULTURES - The invention relates to a method for the production of a Factor VIII polypeptide, the method comprising the steps of a) culturing a mammalian cell expressing a Factor VIII polypeptide under conditions for expression of said Factor VIII polypeptide, said culturing conditions involving a cell culture medium comprising a C2-domain ligand, and b) isolating the expressed Factor VIII polypeptide from the mammalian cell by suitable means.05-13-2010
20100075380Novel Lipase - The present invention provides a novel lipase with a molecular weight of about 32 kDa, which is produced by a strain belonging to the genus 03-25-2010
20090233334CELL CULTIVATION AND PRODUCTION OF RECOMBINANT PROTEINS BY MEANS OF AN ORBITAL SHAKE BIOREACTOR SYSTEM WITH DISPOSABLE BAGS AT THE 1,500 LITER SCALE - The present invention provides a novel method for culturing cells as well as a novel method for producing a recombinant protein by culturing cells at large scale (up to 1,500 L nominal volume and 750 L working volume), whereby an inflated bag provides a sterile, disposable cultivation chamber. The inflated bag is partially filled with liquid cultivation media and cells, and placed into a containment vessel. The containment vessel is positioned onto an orbitally shaken platform. The orbital shaking moves the containment vessel and thus the bag and induces thereby motion to the liquid contained therein (“shake mixing”). This motion (caused by orbital shaking) induces a dynamic force field that ensures cell suspension, bulk mixing, and oxygen transfer from the liquid surface to the respiring cells without damaging shear or foam generation.09-17-2009
20090047711BIS-SULFHYDRYL MACROCYCLIZATION SYSTEMS - The present invention provides novel peptidomimetic macrocycles and methods for their preparation and use, as well as amino acid analogs and macrocycle-forming linkers, and kits useful in their production.02-19-2009
20090148907NOVEL FRUCTOFURANOSIDASE ACTIVITY FOR OBTAINING THE PREBIOTIC OLIGOSACCHARIDE 6-KESTOSE - The invention relates to a novel fructofuranosidase activity for obtaining the prebiotic oligosaccharide 6-kestose. One object of the invention is to characterize a novel transfructosylase activity which is associated with the extracellular invertase of 06-11-2009
20090142808NOVEL ENZYME WITH FRUCTOFURANOSIDASE ACTIVITY, WHICH IS USED TO OBTAIN PREBIOTIC OLIGOSACCHARIDES - The invention relates to a method of obtaining industrially-viable prebiotic oligosaccharides, using a novel extracellular enzyme (fructofuranosidase) of 06-04-2009
20090098610Polypeptides having dna polymerase activity - A polypeptide having a high fidelity DNA polymerase activity and thus being useful as a genetic engineering reagent; a gene encoding this polypeptide; a method of producing the polypeptide; and a method of amplifying a nucleic acid by using the polypeptide.04-16-2009
20090148908COMPOSITIONS AND METHODS FOR GENERATING ANTIBODIES - The compositions and methods of the present invention comprise the efficient and effective presentation of antigens to the appropriate components of the immune system resulting in the production of species-specific antibodies in vitro. In general, these compositions comprise one or more antigenic components together with a colloidal metal, optionally combined with derivatized PEG (polyethylene glycol) or other agents. The invention also comprises novel cytokine cocktails for generating desired antibodies.06-11-2009
20100086970THERMUS SCOTODUCTUS NUCLEIC ACID POLYMERASES - The invention provides nucleic acids and polypeptides for a nucleic acid polymerase from a thermophilic organism, 04-08-2010
20110171690ANGIOTENSIN CONVERTING ENZYME INHIBITORY PEPTIDE - To provide ACE inhibitory peptides which can effectively inhibit ACE by a small amount of ingestion and have no fear of causing side effects and which can be orally ingested easily during daily life by persons having high blood pressure, and compositions comprising the peptides. The peptides represented by the following structural formulae (1) to (9), and salts thereof are provided. (1) Asp-Arg-Pro, (2) Asn-Trp, (3) Val-Gly-Leu, (4) Ile-Gly-Val, (5) Gly-Val-Pro, (6) Ile-Pro-Tyr, (7) pyroGlu-Pro, (8) Tyr-Thr, (9) Pro-Trp07-14-2011
20090081733METHODS FOR PRODUCING AND USING POLYMYXINS - The present invention provides methods for producing a polymyxin from an isolated 03-26-2009
20090258396CRUSTACEANS AS PRODUCTION SYSTEMS FOR THERAPEUTIC PROTEINS - A crustacean or rotifer is infected with a recombinant infectious virus that expresses a protein exogenous to the virus. The genome of the crustacean or rotifer itself remains unaltered. Crustacean, rotifer, insect, or viral promoters drive the transcription of a gene inserted into the recombinant virus genome, and the virus replicates in the crustacean or rotifer cell cytoplasm. The infected crustacean or rotifer can be provided directly to humans or non-human animals, or, following production and harvest of the crustaceans or rotifers, purified recombinant protein or polypeptide can be provided. Large quantities of biopharmaceuticals can be produced rapidly and inexpensively using this production system.10-15-2009
20100184149 Method For Producing a Biopolymer (e.g. polypeptide) In A Continuous Fermentation Process - A method for improving productivity in microbial fermentations and mammalian cell culture bioreactors.07-22-2010
20100151525METHOD FOR EXTRACTING HYDROPHOBIN FROM A SOLUTION - Process for extracting hydrophobin from a solution wherein carrageenan is added to the solution and the pH of the solution is brought below 3.5, and the ionic strength of the solution is below 0.5.06-17-2010
20100136628Novel OX40R Binding Agents - The present invention discloses peptides isolated from the extracellular domain of OX40 Ligand (OX40L) capable of binding OX40 Receptor (OX40R) and inhibiting OX40R-OX40L interaction. Such peptides, fusion proteins comprising them, as well as peptides and other molecules designed on their sequences, can be used as OX40R binding agents competing with natural OX40L for blocking OX40R-mediated cell signaling in the prophylaxis and/or treatment of diseases related to activated T cells.06-03-2010
20090111148IMMOBILIZED MICROBIAL NITRILASE FOR PRODUCTION OF GLYCOLIC ACID - The present invention is directed to a process for improving the specific activity of a dehydrated enzyme catalyst having nitrilase activity for hydrolysis of glycolonitrile to glycolic acid upon rehydration. In particular, a process is provided comprising pretreating an enzyme catalyst having nitrilase activity with glutaraldehyde, immobilizing the gutaraldehyde-preteated enzyme catalyst and chemically cross-linking the enzyme catalyst prior to dehydration. Upon rehydration, the enzyme catalyst exhibits improved specific nitrilase activity as compared to enzyme catalysts having nitrilase activity that are dehydrated and rehydrated without the processing described herein.04-30-2009
20100297702Protein markers associated with bone marrow stem cell differentiation into early progenitor dendritic cells - A novel cytosolic 58 kd phosphoprotein induced during bone marrow stem cell (BM) differentiation into dendritic cells (DC) during in vitro cultivation with the cytokine GM-CSF by addition of antisera to an 82 kd BM cell surface protein generating cultivatable dendritic progenitor cells (DP). Genes, methods for preparing them as well as early DP have been provided. Potential uses/advantages lie in the study of BM differentiation and innate immunity due to stimulatory/inhibitory DC, contribution of BM and DP to inflammation during infection and carcinogenesis, tumor promotion/regression, identification of BM-derived blood cells, T-cell activation/regulation/tolerance and inflammation.11-25-2010
20130164787CELL COMPOSITIONS DERIVED FROM DEDIFFERENTIATED REPROGRAMMED CELLS - Disclosed herein are cell culture compositions, for example, pancreatic cell culture compositions, derived from dedifferentiated human reprogrammed pluripotent stem cells, such as induced pluripotent stem (iPS) cells, and methods for producing and using such cell culture compositions.06-27-2013
20100178675SYSTEM FOR EXTRACTING PROTEIN FROM A FERMENTATION PRODUCT - A method of producing bioproducts from a feedstock in a system configured to produce ethanol and distillers grains from a fermentation product is disclosed. A system configured to process feedstock into a fermentation product and bioproducts including ethanol and meal is disclosed. A bioproduct produced from a fermentation product produced from a feedstock in a biorefining system is disclosed.07-15-2010
20100178676METHODS FOR ANTIBODY PRODUCTION - The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates in vitro and thus, is useful to accelerate vaccine development and testing drug and chemical interactions with the immune system.07-15-2010
20110117604COPPER-ENRICHED BIOMASS, METHOD FOR THE PREPARATION THEREOF AND PRO-BIOTIC , COSMETIC, DIETARY AND NUTRACEUTIC PRODUCTS COMPRISING THE SAME - The invention relates to a method for the preparation of a copper-enriched biomass, comprising, in a first step, culturing 05-19-2011
20110244519USE OF RNA TRANS-SPLICING FOR ANTIBODY GENE TRANSFER AND ANTIBODY POLYPEPTIDE PRODUCTION - The present invention provides methods and compositions for generating novel nucleic acid molecules through RNA trans-splicing that target a highly expressed pre-mRNA and contain the coding sequence for antibody polypeptide(s). The compositions of the invention include pre-trans-splicing molecules (PTMs) designed to interact with the target precursor messenger RNA molecule (target pre-mRNA) that is abundantly expressed or tumor specific and mediate a trans-splicing reaction resulting in the generation of novel chimeric RNA molecule (chimeric RNA) capable of encoding an antibody polypeptide. The invention provides for the in vivo production of chimeric RNA molecules that encode and result in the production of an antibody polypeptide that is therapeutically effective against, for example, infectious agents, cancer cells, transplantation antigens, rheumatoid arthritis, etc.10-06-2011
20100062491Overexpression of the Chaperone BIP in a Heterokaryon - The present invention relates to a method for increasing the production yield of a secreted antibody or antibody fragment in a filamentous fungal host cell, comprising: recombinant expression of the antibody or antibody fragment and over-expressing a BiP chaperone protein.03-11-2010
20090215121Process for Preparing High Levels of Interferon Beta - The present invention relates to a novel process for the production of interferon-beta in improved yields by fermentation.08-27-2009
20110033894ENGINEERING SURFACE EPITOPES TO IMPROVE PROTEIN CRYSTALLIZATION - Methods and systems for engineering surface epitopes, based on protein sequence characteristics with statistically significant influence on the likelihood of x-ray structure solution, to improve protein crystallization, as well as related material, are disclosed.02-10-2011
20080213840Compositions Containing, Methods Involving, and Uses of Non-Natural Amino Acids and Polypeptides - Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.09-04-2008
20080254514Production of a Polypeptide in a Serum-Free Cell Culture Liquid Containing Plant Protein Hydrolysate - The invention concerns a method for large-scale production of a polypeptide in eukaryote cells contained in a serum-free culture liquid, said method comprising (i) a propagation phase for said cells, where the cells are propagated in a first cell culture liquid, and (ii) a production phase for said cells, where the cells are present in a second cell culture medium liquid, wherein each of the cell culture liquids comprise a plant protein hydrolysate, and wherein the ratio between the concentration of the plant protein hydrolysate (C10-16-2008
20110053225MULTIFUNCTIONAL TAGS - The present invention relates to multifunctional protein production tags comprising at least 4, preferably 4-8 amino acids, for optimising expression of proteins and purification thereof by various multi-step processes including chromatographic or filtration, as well as batch unit operations. The tags include sequences of multiple defined purposes which are not generated in defined linear sequence regions related to one purpose but as integrated sequences often overlapping each other, i.e. the defined purposes are not discrete separate units on the tag but rather heterogeneously distributed in the tag. The invention also relates to an expression vector encoding the multipurpose tag and a method for protein purification, comprising expressing a protein in the expression vector and purifying the protein in several steps using functionalities of the multipurpose tag.03-03-2011
20100285533CULTURE MEDIA ADDITIVE AND PROCESS FOR USING IT - The present invention relates to an improved cell culture additive with a content of polyamines and iron, media containing it and processes for using it for an improved cell growth, cell viability or cellular productivity.11-11-2010
20110033896METHOD FOR MANUFACTURING AN AQUEOUS GLUCOSE SOLUTION FROM PLANTS OF THE TRITICEAE SPECIES - The present invention relates to a method for manufacturing an aqueous glucose solution from the starch components of Triticeae grains, for example from rye, triticale or in particular wheat grains. The invention also relates to a glucose-based fermentation method for manufacturing organic compounds in which the glucose manufactured for fermentation is produced from the starch components of Triticeae grains by way of a method according to the invention.02-10-2011
20100323401GENERAL METHOD FOR GENERATING HUMAN ANTIBODY RESPONSES IN VITRO - This invention relates to an in vitro method of producing antigen specific B cells and antibodies that provides for the capture of an entire primary human antibody repertoire for any foreign antigen, allows for screening large numbers of immunogen/adjuvant combinations, and permits the isolation of human monoclonal antibodies on demand thereby obviating the need to immunize humans with the target antigen.12-23-2010
20100159514SYSTEM FOR PRODUCTION OF ETHANOL AND CO-PRODUCTS WITH FRACTIONATION OF FEEDSTOCK AND SOLVENT WASHING OF FERMENTATION PRODUCT - A system for the production of ethanol and co-products is provided. The system facilitates an overall reduction in the use of energy, for example, by reducing the mass of wet solids supplied to a distillation system. The system also reduces the amount of energy used to dry the wet solids component of a fermentation product, for example, by increasing the ethanol concentration of the wet solids. The system also facilitates the recovery of co-products including bioproducts and other biochemicals extracted from components of the fermentation product. The solids component of the fermentation product may be dried and constituted into a meal that may be used for animal feed, among other uses.06-24-2010
20110262969METHOD FOR PRODUCING OPTICALLY ACTIVE, CYCLIC DEPSIPEPTIDES COMPRISING LACTIC ACID AND PHENYL LACTIC AND HAVING 24 RING ATOMS, USING FUNGUS STRAINS OF ROSELLINIA TYPE, AND FURTHER SPECIES OF XYLARIACEAE - The present invention relates to a process for the preparation of lactic- and phenyllactic-acid-containing, optically active, cyclic depsipeptides with 24 ring atoms by means of fungal strains of the genus 10-27-2011
20120149064Filamentous Fungi With Impaired PTRB Activity For Altered Protein Production - A filamentous fungal cell is provided comprising at least one mutation, wherein the filamentous fungal cell has impaired ptrB activity and has altered expression of a protein of interest as compared to a corresponding parent filamentous fungal cell. In one embodiment, the altered expression of the protein of interest is enhanced expression of the protein of interest.06-14-2012
20090011468Method for improving protein production - The present invention relates to the production of proteins in a cell or host cell. The invention uses a TRAnscription Pause (TRAP) sequence to enhance a protein expression characteristic of a protein expression unit. The TRAP sequence is thought to prevent, at least in part, formation of antisense RNA or to, at least in part, prevent transcription to enter the protein expression unit. In one embodiment, the invention provides a method for expression of at least one protein of interest in a cell comprising providing the cell with at least one protein expression unit that comprises a promoter functionally linked to an open reading frame encoding at least one protein of interest, characterized in that the protein expression unit further comprises at least one TRAP sequence and wherein the TRAP sequence is functionally located downstream of the open reading frame and at least in part prevents formation of antisense RNA. In another embodiment, the TRAP sequence is functionally located upstream of the promoter and at least in part prevents transcription to enter the expression unit. Preferably, the expression protein unit further comprises at least one STabilizing Anti-Repressor sequence.01-08-2009
20100021968NOVEL CHLORELLA SPECIES AND USES THEREFOR - The present invention relates to algal species and compositions, methods for identifying algae that produce high lipid content, possess tolerance to high CO01-28-2010
20100255541Advanced Algal Photosynthesis-Driven Bioremediation Coupled with Renewable Biomass and Bioenergy Production - The present invention relates to algal species and compositions, methods for identifying algae that produce high lipid content, possess tolerance to high CO10-07-2010
20090280536EXPRESSION SYSTEM FOR PROTEINS - The invention provides a novel system for the tunable expression of nucleic acids encoding e.g., polypeptides such as recombinant proteins in prokaryotic systems. The system is based on the ability of T7 lysozyme (T7Lys) to inhibit the activity of T7RNAP. Expression of T7Lys can be continuously adjusted as its expression is under the control of a promoter whose activity can be titrated. The invention provides a host cell capable of expressing T7 RNA polymerase, the host cell comprising a first nucleic acid having a T7 lysozyme gene or a T7 lysozyme variant gene and a tunable promoter for controlling the expression of the T7 lysozyme gene. It also provides a host cell further comprising a second nucleic acid having a T7 promoter operably linked to a nucleic acid sequence encoding a target polypeptide, whereby expression of the target polypeptide is tuned via controlling the expression of the T7 lysozyme gene.11-12-2009
20090317870INDUSTRIALLY USEFUL MICROORGANISM - The present invention provides a microorganism which comprises a chromosomal DNA lacking a part or entire of the gene encoding a protein having the amino acid sequence as shown in SEQ ID NO: 1 or 2, or the gene encoding a protein having 80% or more homology with the amino acid sequence as shown in SEQ ID NO: 1 or 2, and has the ability to produce a useful substance; a process for producing a useful substance using said strain; especially a process for producing a useful substance which is selected from the group consisting of proteins, peptides, amino acids, nucleic acids, vitamins, saccharides, organic acids, and lipids.12-24-2009
20120058514COLD ACTIVE ENZYME AND METHOD THEREOF - The objective of the present invention is to obtain a low temperature producing enzyme and more particularly, the enzyme provides a bifunctional purpose of varying its enzyme activity into activity of another enzyme. The present invention has overcome problems such as ability of obtaining an enzyme at low temperature.03-08-2012
20100093039Cell Culture Media for Enhanced Protein Production - Culture media for in vitro cell culture which contain substantially saturated amounts of selected amino acids improve protein production, constrain cell growth and extend cell longevity, methods for the production and use of such media, and systems fox the production of protein utilizing such media and methods.04-15-2010
20100093038Means and Methods for Influencing the Stability of Cells - The invention provides a method for influencing the stability of an antibody producing cell, comprising directly or indirectly influencing the amount of BCL6 and/or Blimp 1 expression product within said antibody producing cell. Stable antibody producing cells and cell lines are also provided, as well as methods for producing antibodies using such cells and/or cell lines.04-15-2010
20120129220PROCESS FOR PRODUCTION OF USEFUL SUBSTANCE, AND SURFACTANT FOR USE IN THE PROCESS - The present invention is aimed to provide a method for industrially producing a useful substance (protein etc.) utilizing a bacterium such as 05-24-2012
20120219993METHOD OF PRODUCING MICROBIAL INTRACELLULAR PRODUCTS FROM VOLATILE FATTY ACIDS - A method for producing microbial intracellular products, and more particularly a method of producing microbial intracellular products from volatile fatty acids derived from organic waste is provided. The method of producing microbial intracellular products from volatile fatty acids in a multi-stage continuous high-cell-density culture bioreactor system includes the steps of: (a) culturing microorganisms in a bioreactor for microbial growth, thereby growing the microorganisms; (b) culturing the grown microorganisms of step (a) in a bioreactor for production of microbial intracellular products, which includes a medium containing volatile fatty acids, thereby producing microbial intracellular products; and (c) recovering the intracellular microbial products from the culture medium of the bioreactor for production of microbial intracellular products.08-30-2012
20120178128PROCESS FOR PRODUCING CYSTEINE AND/OR GLUTATHIONE FROM CYSTINE EMPLOYING YEAST - The invention provides a process for the conversion of cystine to cystein and/or glutathione comprising contacting cystine with a microorganism. The invention also relates to a yeast extract comprising at least 1.8 mg/g cystein and a yeast autolysate comprising at least 1.3 mg/g cystein.07-12-2012
20100291629USE OF DELEUCOCYTATION FILTERS FOR DEFENSIN PURIFICATION - The invention concerns the use of deleucocytation filters for defensin purification. More precisely, the invention concerns a method for purifying defensins, including the following steps: passing a blood sample on a deleucocytation filter; detaching the cells retained on the deleucocytation filter, inducing exocytosis of the defensins by those cells.11-18-2010
20110033895Method For Producing Human Antibodies With Properties Of Agonist, Antagonist, or Inverse Agonist - A method for obtaining agonist, antagonist and inverse agonist, to a given physiological receptor is disclosed. For the method, use is made of in silico design synthetic immunogens, which are caused to act in vitro on human lymphocyte-containing cell populations. A preferred receptor is human CD152, particularly the regions of CDR1, CDR2 and CDR3 that elicit antibodies serving as antagonist, inverse agonist and agonist, respectively. Also provided is a method in the treatment of human peripheral lymphocytes for use in the screening of CD152 ligands that yield pharmacological effects.02-10-2011
20110236932BIOPHARMACEUTICAL PLANT IN A COLUMN - The present invention relates to a series of therapeutic material processing devices stacked into a column, hereby creating a bio material process plant with extremely small foot-print and all the processing devices being of single-use capabilities for lowest possible cost and methods of operating said column.09-29-2011
20100233761ALGAE BIOMASS FRACTIONATION - A method of fractionating biomass, by permeability conditioning biomass suspended in a pH adjusted solution of at least one water-based polar solvent to form a conditioned biomass, intimately contacting the pH adjusted solution with at least one non-polar solvent, partitioning to obtain an non-polar solvent solution and a polar biomass solution, and recovering cell and cell derived products from the non-polar solvent solution and polar biomass solution. Products recovered from the above method. A method of operating a renewable and sustainable plant for growing and processing algae.09-16-2010
20130017577METHODS FOR ENHANCED PROTEIN PRODUCTION - The present invention provides a method of increasing protein production in a cell culture by growing cells that produce the protein (e.g., the growth phase) in a perfusion cell culture to a high cell density (i.e., at least above about 40×1001-17-2013
20110159543SCALABLE PROCESS FOR CULTURING PER.C6 CELLS AND PRODUCING PRODUCTS THEREFROM - The invention provides methods for culturing adherent PER.C6 cells and producing products therefrom.06-30-2011
20080254515Fermentative Production of Organic Compounds - The invention relates to a method for producing at least one organic compound comprising at least 3 C-atoms or at least 2 C-atoms and at least 1 N-atom by fermentation. Said method comprises the following steps: i) a starch source is ground in order to obtain a grinding material which contains at least one part of the non-starch containing solid components of the starch source; ii) the grinding material is suspended in an aqueous liquid in an amount such that the dry mass content in the suspension is at least 45 wt. %, iii) the starch component is hydrolysed in the grinding material by liquefying and optionally, subsequently, sweetening, in order to obtain an aqueous medium M, which contains the hydrolysed starch components and at least one part of the non-starch containing solid components of the starch source, is obtained; and iv) the aqueous substance M obtained in step iii) is used for fermentation in order to cultivate a micro-organism which is capable of over-producing the organic compound; the suspension obtained in step ii) is heated in step iii) by introducing vapour into the suspension, in order to obtain temperatures greater than the pasting temperature of the starch obtained in the grinding materials.10-16-2008
20080241886Process For the Treatment of Methane Emissions - The invention relates generally to a system and method for the treatment of gaseous emissions comprising methane, and in one specific embodiment, to a system and method for the treatment of emissions through the use of methanotrophic microorganisms. Certain embodiments of the invention are particularly advantageous because they reduce environmentally-destructive methane emissions and produce harvestable end-products.10-02-2008
20080241885PROCESS FOR PRODUCING CELLULASE - Various methods for the production of cellulase are disclosed. In one embodiment the method for producing cellulase includes contacting a culture comprising a sophorolipid producer and a cellulase producer with a substrate that is consumed by the sophorolipid producer. In addition, a microorganism culture made from a sophorolipid producer and a cellulase producer is disclosed.10-02-2008
20080220480METHOD FOR PRODUCING METHANOL, DIMETHYL ETHER, DERIVED SYNTHETIC HYDROCARBONS AND THEIR PRODUCTS FROM CARBON DIOXIDE AND WATER (MOISTURE) OF THE AIR AS SOLE SOURCE MATERIAL - A method for producing methanol and dimethyl ether using the air as the sole source of materials is disclosed. The invention relates to a method for producing methanol by removing water from atmospheric air, obtaining hydrogen from the removed water, obtaining carbon dioxide from atmospheric air; and converting the carbon dioxide under conditions sufficient to produce methanol. Thereafter, the methanol can be dehydrated to produce dimethyl ether or further processed to produce synthetic hydrocarbons, polymers, and products derived from them.09-11-2008
20080220479Polynucleotides encoding IL-17 receptor a antigen binding proteins - The present invention relates to IL-17 receptor A (IL-17RA or IL-17R) antigen binding proteins, such as antibodies, and the polynucleotide sequences encoding them, as well as host cells, expression vecotors, and methods of making IL-17 receptor A antigen binding proteins.09-11-2008
20090011467NOVEL FRUCTOSYL PEPTIDE OXIDASE - The present invention has an object of providing a novel fructosyl peptide oxidase having superior physicochemical properties such as stability that is useful as an enzyme for clinical diagnosis, and an object of providing a method for producing the fructosyl peptide oxidase.01-08-2009
20130102033PRODUCTION METHOD OF EXTRACELLULAR POLYSACCHAROPEPTIDES BY TRAMETES VERSICOLOR LH1 IMMOBILIZATION USING LIQUID-SURFACE COMPLEX CARRIERS IN SUBMERGED FERMENTATION - The present invention relates to a culture method for enhancing the production of the extracellular polysaccharopeptides (EPS) by submerged fermentations with a mycelium immobilization by a local 04-25-2013
20100279354ADAPTING MICROORGANISMS FOR AGRICULTURAL PRODUCTS - Disclosed herein are methods and compositions to convert a carbonaceous material to produce a fatty acid, biofuel, biodiesel, or other useful end-product. Organisms are evolutionarily modified to utilize carbon and/or nitrogen sources available in a carbonaceous material. Culture of the evolutionarily modified organism on the carbonaceous material in turn produces a fatty acid, biofuel, biodiesel, or other useful end-product by a process of conversion performed by evolutionarily modified organisms.11-04-2010
20080206820Labeling Methods with Oxygen Isotopes - The present invention provides methods for labeling One or two oxygen atom(s) in a carboxyl group of a carboxyl-containing compound with an oxygen isotope selected from oxygen-17 (08-28-2008
20110275123Compositions and methods for generating antibodies - The compositions and methods of the present invention comprise the efficient and effective presentation of antigens to the appropriate components of the immune system resulting in the production of species-specific antibodies in vitro. In general, these compositions comprise one or more antigenic components together with a colloidal metal, optionally combined with derivatized PEG (polyethylene glycol) or other agents. The invention also comprises methods and compositions for making such colloidal metal compositions.11-10-2011
20100317056FERMENTATION MEDIAS AND PROCESSES THEREOF - The present invention demonstrates the utility of carbonic acid amides such as urea or its derivatives, carbamates, carbodiimides & thiocarbamides as nitrogenous supplements in fermentation media for production of recombinant proteins to achieve enhanced bioconversion rates and peptides like insulin and insulin analogues, exendin and enzymes such as lipase using methanol inducible fungal expression systems such as 12-16-2010
20130157314Compositions Comprising A Polypeptide Having Cellulolytic Enhancing Activity And A Heterocyclic Compound And Uses Thereof - The present invention relates to compositions comprising: a polypeptide having cellulolytic enhancing activity and a heterocyclic compound. The present invention also relates to methods of using the compositions.06-20-2013
20090215122Process for Producing Thioredoxin - An object of the present invention is to provide a process for conveniently and efficiently producing high purity thioredoxin from yeast.08-27-2009

Patent applications in class Using a micro-organism to make a protein or polypeptide

Patent applications in all subclasses Using a micro-organism to make a protein or polypeptide