| Class / Patent application number | Description | Number of patent applications / Date published |
|---|
| 435052000 | Preparing compound containing a cyclopentanohydrophenanthrene nucleus; nor-, homo-, or D-ring lactone derivatives thereof | 57 |
| 20080248520 | Process for Production of 5-Ene-3-One or 3,6-Dione Derivatives of Sterols, Processes for Production of Lipid Metabolism Improvers, Foods, Drinks, and Animal Feeds, and Analytical Method - An object of the present invention is to provide a process according to which 5-ene-3-one or 3,6-dione derivatives of sterols can be synthesized with a better yield, as well as a process for production of lipid metabolism improvers, foods, drinks, and animal feeds containing the 5-ene-3-one or 3,6-dione derivatives of sterols. | 10-09-2008 |
| 20100099141 | Method and intermediates for preparing 2-alkoxy and 2-aryloxy estrogen compounds - The present invention relates to a method for preparing 2-alkoxy and 2-aryloxyestrogen compounds, and the intermediate compounds prepared during the use of this method, which intermediate compounds are useful intermediates in the preparation of certain physiologically active compounds. | 04-22-2010 |
| 20100112634 | YEAST STRAINS AUTONOMOUSLY PRODUCING STEROIDS - The present invention relates to genetically modified yeast strains autonomously producing, from a simple carbon source, steroids. The invention also relates to a method for producing steroids from such yeast strains. | 05-06-2010 |
| 20110104749 | MODIFIED YEASTS AND USES THEREOF, IN PARTICULAR FOR PRODUCING STEROID DERIVATIVES - The present invention relates to novel yeast strains, methods and genetic constructs for their preparation, and their use for the synthesis or modification of steroidal compounds. More particularly, the invention describes strains having a reduced 20αHSD type activity, in particular by modifying the GCY1 and/or YPR1 genes. The yeast strains of the invention make it possible to improve the efficiency of the synthesis or to increase the selectivity or the yields of the method, as well as the quality of the final product. The strains, methods and compounds of the invention are useful in the search for, the development and the production of products with therapeutic or prophylactic activity, in humans or animals, in particular of steroidal derivatives. | 05-05-2011 |
| 20110124041 | Method of producing tibolone metabolites by fermentation with Rhizopus stolonifer - A new method of producing metabolites of tibolone comprising fermenting tibolone with | 05-26-2011 |
| 20110124042 | Method of producing tibolone metabolites by fermentation with Fusarium lini - Method of producing Δ | 05-26-2011 |
| 20110151509 | PREPARATION OF 7-DEHYDROCHOLESTEROL AND/OR THE BIOSYNTHETIC INTERMEDIATES AND/OR SECONDARY PRODUCTS THEREOF IN TRANSGENIC ORGANISMS - The present invention relates to a method for preparing 7-dehydrocholesterol and/or the biosynthetic intermediates and/or secondary products thereof by culturing organisms, in particular yeasts. Furthermore, the invention relates to the preparation of the nucleic acid constructs required for preparing the genetically modified organisms and to said genetically modified organisms, in particular yeasts, themselves. | 06-23-2011 |
| 20110207171 | OLIGOSACCHARIDE MODIFICATION AND LABELING OF PROTEINS - The present invention generally relates to methods of functionalizing proteins, particularly antibodies, at oligosaccharide linkages, methods of humanizing antibodies by modifying glycosylation, as well as to novel antibodies linked to modified oligosaccharides. The invention further relates to kits that may be used to produce the antibodies of the invention. | 08-25-2011 |
| 20110269181 | METHOD AND SYSTEM FOR CONTINUOUS BIOTRANSFORMATION - One embodiment of the present invention discloses a method for continuous biotransformation. The method is continuously supplying viable biocatalyst cells or biocatalyst biomolecules to a bioreactor containing substrate mediums, so as to mediate the substrate mediums to be converted into the desired bioproducts. | 11-03-2011 |
| 20120003690 | ENZYMATIC GENERATION OF FUNCTIONAL LIPIDS FROM CEREALS OR CEREAL BI-STREAMS - The present invention relates to the modification of lipids in lipid-containing plant material, such as cereal bran for the generation of functional lipids. The present invention further relates to the preparation of compositions comprising such functional lipids as well as the use of these compositions comprising functional lipids and other functional compounds derived from the action of lipid modifying enzymes for the preparation of composition suitable for the preparation of bio-ethanol as well as food products, such as bread. | 01-05-2012 |
| 20120094328 | FERMENTATION PRODUCT OF CEREAL PLANT-DERIVED MATERIAL AND IMMUNOMODULATOR - The present invention provides dendritic cells (DCs) having reduced inflammatory activity, a method for producing DCs capable of inducing regulatory T cells and regulatory T cells, and substances useful for such a method, wherein the DCs and regulatory T cells are useful for prevention and treatment of immune diseases. The present invention relates to a cereal plant-derived material fermented with a koji microorganism, which is obtained by fermentation thereof with a koji microorganism, or a processed product thereof. Preferably, the fermented product or a processed product thereof comprises 14-dehydroergosterol. According to the present invention, regulatory DCs and regulatory T cells can be induced and the proliferation of inflammatory T cells can be suppressed using plant-derived materials. | 04-19-2012 |
| 20120156717 | BIOFUEL FROM RECOMBINANT OLEAGINOUS ALGAE USING SUGAR CARBON SOURCES - Recombinant oleaginous alga that include one or more heterologous genes that increase the ability of the alga to use one or more natural saccharides such as cellulosic or hemicellulosic sugars for algal growth are described. The recombinant oleaginous algae are transformed to include one or more genes expressing sugar metabolizing enzymes or sugar transporting proteins, along with suitable control elements. Use of natural saccharides as a carbon source can allow the algae to produce biofuel precursors in a relatively efficient manner. Processes for preparing the alga, growing the alga, and extracting the biofuel precursors from the alga are also described. | 06-21-2012 |
| 20120171719 | USE OF SACCHAROMYCES CEREVISIAE SUC2 GENE IN YARROWIA LIPOLYTICA FOR SUCROSE UTILIZATION - Disclosed herein are transformed | 07-05-2012 |
| 20120178124 | STEROL SIDE CHAIN-CLEAVING ENZYME PROTEIN AND USE THEREOF - It is an object of the present invention to obtain highly active P450scc enzyme protein which is an important enzyme protein that catalyzes the first step of the biosynthesis of industrially useful steroid hormone. The present invention provides a sterol side chain cleavage enzyme protein having the following physicochemical properties:
| 07-12-2012 |
| 20120214198 | ALGACULTURE METHOD - The present invention relates to bioprocess engineering methods in which aqueous phases of anaerobic biologically treated organic suspensions are supplied to algal cultures as media components. The present invention also relates to the use of aqueous phases of anaerobic biologically treated organic suspensions as media components of algal cultures. Additionally, the present invention relates to the use of aqueous phases of anaerobic biologically treated organic suspensions to improve the growth conditions of algae in photobioreactors. Furthermore, the present invention relates to the use of algae for the treatment of aqueous phases of anaerobic biologically treated organic suspensions, in particular of anaerobic biologically treated sewage filtrate. The present invention also relates to bioprocess engineering devices ( | 08-23-2012 |
| 20120276586 | DESMOSTEROL-PRODUCING YEAST STRAINS AND USES THEREOF - The invention concerns the production of cholesterol of the Fungi kingdom. More particularly, the invention concerns genetically modified Fungus independently producing cholesterol from a simple carbon source. The invention also concerns the use of the inventive Fungus for producing non-marked and marked cholesterol. | 11-01-2012 |
| 20130065270 | Non-Recombinant Saccharomyces Strains that Grow on Xylose - The present invention relates to methods for producing | 03-14-2013 |
| 20130084600 | NATIVE NAD-DEPENDENT GAPDH REPLACED WITH NADP-DEPENDENT GAPDH PLUS NADK - This invention is metabolically engineer bacterial strains that provide increased intracellular NADPH availability for the purpose of increasing the yield and productivity of NADPH-dependent compounds. In the invention, native NAD-dependent GAPDH is replaced with NADP-dependent GAPDH plus overexpressed NADK. Uses for the bacteria are also provided. | 04-04-2013 |
| 20130084601 | NOVEL SOIL MICROORGANISM, NOVEL OXIDOREDUCTASE SEPARATED FROM THE SOIL MICROORGANISM, GENE ENCODING THE OXIDOREDUCTASE, AND METHOD FOR PRODUCING AGLYCONES USING THE MICROORGANISM, THE OXIDOREDUCTASE AND THE GENE - The present invention relates to the novel | 04-04-2013 |
| 20130089892 | YEAST STRAINS MODIFIED IN THEIR SOPHOROLIPID PRODUCTION AND USES THEREOF - The present invention relates to yeast species which are normally capable of producing sophorolipids but which are modified in such way that they are incapable producing the latter compounds. These sophorolipid-negative strains surprisingly display equal growth characteristics and biomass formation as their wild type counterparts and are hence useful for the production of compounds such as recombinant proteins, glycolipids, polyhydroxyalkanoates and carotenoides. In addition, the present invention discloses two glucosyltransferase genes with key-functions in sophorolipid production. | 04-11-2013 |
| 20130210072 | PREPARATION OF 7-DEHYDROCHOLESTEROL AND/OR THE BIOSYNTHETIC INTERMEDIATES AND/OR SECONDARY PRODUCTS THEREOF IN TRANSGENIC ORGANISMS - The present invention relates to a method for preparing 7-dehydrocholesterol and/or the biosynthetic intermediates and/or secondary products thereof by culturing organisms, in particular yeasts. Furthermore, the invention relates to the preparation of the nucleic acid constructs required for preparing the genetically modified organisms and to said genetically modified organisms, in particular yeasts, themselves. | 08-15-2013 |
| 20130224792 | Novel 7 alpha-Hydroxysteroid Dehydrogenase Knockout Mutants and Use Therefor - The invention relates to novel microbial 7α-hydroxysteroid dehydrogenase (7α-HSDH) knockout mutants and to the use thereof for producing other HSDHs having various functionalities, such as 3α-, 7β- or 12α-HSDH, and to the use of thus-produced HSDH enzymes in enzymatic reactions of cholic acid compounds, and in particular for producing ursodeoxycholic acid (UDCS). The invention relates in particular to novel methods for synthesizing UDCS. | 08-29-2013 |
| 20140186885 | PROCESS FOR PREPARING GENETICALLY TRANSFORMED YEASTS CAPABLE OF PRODUCING A MOLECULE OF INTEREST AT A HIGH TITRE - The subject of the present invention is a process for preparing a genetically modified yeast by multicopy integration of at least four expression cassettes, allowing the production of a molecule of interest at high titre. The subject of the present invention is also yeasts transformed according to said process, and the use thereof for producing hydrocortisone. | 07-03-2014 |
| 20140329275 | BIOCATALYSIS CELLS AND METHODS - In one aspect, the invention provides a recombinant microbial cell modified to exhibit increased biosynthesis of a biosynthetic product compared to a wild-type control. In some cases, the biosynthetic product can be isocaproate; in other cases the biosynthetic product can be isovalerate. In another aspect, the invention provides methods of constructing such recombinant cells. In yet another aspect, the invention provides methods of using the cells to produce the biosynthetic product. In yet another aspect, the invention provides methods of harvesting organic acids from a fermentation culture. | 11-06-2014 |
| 20140377798 | PROCESS FOR THE ENZYMATIC REGENERATION OF REDOX COFACTORS - A process for the enzymatic regeneration of the redox cofactors NAD | 12-25-2014 |
| 20150031077 | CONVERSION SYSTEMS FOR BIOMASS - The efficient production of ethanol from low-cost biomass (e.g., corn, sugar beets, sugar cane, switchgrass and/or paper) has become increasingly important in making ethanol competitive with gasoline and decreasing the United States' dependence on foreign oil. For example, to reduce the cost of transporting biomass to ethanol production facilities, mobile systems for producing ethanol from biomass are provided. Also provided are small-scale ethanol production facilities. For example, instead of transporting biomass to the production facility, the facility is transported to the biomass or is located nearby the source of the biomass. The ethanol production facilities or components thereof may be transported via land, water, or air. Production of other products, such as hydrocarbons, natural gas, hydrogen gas, plastics, polymers, and proteins, can also be made by the methods and facilities. Any product described herein can be made in finished form or un-finished form and moved, e.g., to a fixed facility, e.g., fixed production facility. | 01-29-2015 |
| 20150093781 | MICROORGANISM FOR EXPRESSING A HUMAN MEMBRANE PROTEIN - The invention relates to an isolated, genetically modified, living non-mammal organism, having increased HMG-CoA-reductase activity compared to the wild type, and having reduced C24-methyltransferase and/or delta22-desaturase activity compared to the wild type. The invention is characterized in that the organism has increased dehydrocholesterol-delta70-reductase activity compared to the wild type. The invention further relates to different uses of such an organism, to a test kit comprising such an organism, and to a membrane extract of such an organism. | 04-02-2015 |
| 20150353980 | PREPARATION OF 7-DEHYDROCHOLESTEROL AND/OR THE BIOSYNTHETIC INTERMEDIATES AND/OR SECONDARY PRODUCTS THEREOF IN TRANSGENIC ORGANISMS - The present invention relates to a method for preparing 7-dehydrocholesterol and/or the biosynthetic intermediates and/or secondary products thereof by culturing organisms, in particular yeasts. Furthermore, the invention relates to the preparation of the nucleic acid constructs required for preparing the genetically modified organisms and to said genetically modified organisms, in particular yeasts, themselves. | 12-10-2015 |
| 20160002672 | PRODUCTION OF ISOPRENE, ISOPRENOID, AND ISOPRENOID PRECURSORS USING AN ALTERNATIVE LOWER MEVALONATE PATHWAY - The invention provides for compositions and methods for the production of isoprene, isoprenoid precursor, and/or isoprenoids in cells via the expression (e.g., heterologous expression) of phosphomevalonate decarboxylases and/or isopentenyl kinases. | 01-07-2016 |
| 20160024457 | PRODUCTION OF SQUALENE AND/OR STEROL FROM CELL SUSPENSIONS OF FERMENTED YEAST - The present invention relates to a process for the production of squalene and/or sterol in high amounts using an alkaline solution and an organic lysis solvent at high temperature and high pressure for effectively lysing yeast cells and extracting squalene and/or sterol into an organic extraction solvent, thus obtaining squalene and/or sterolin high amount and of high purity. | 01-28-2016 |
| 20160032323 | RECOMBINANT MICROORGANISMS FOR ENHANCED PRODUCTION OF MEVALONATE, ISOPRENE, AND ISOPRENOIDS - The invention features compositions and methods for the increased production of mevalonate, isoprene, isoprenoid precursor molecules, and/or isoprenoids in microorganisms by engineering a microorganism for increased carbon flux towards mevalonate production in the following enzymatic pathways: (a) citrate synthase, (b) phosphotransacetylase, (c) acetate kinase, (d) lactate dehydrogenase, (e) malic enzyme, and (f) pyruvate dehydrogenase such that one of more of the enzyme activity is modulated. In addition, production of mevalonate, isoprene, isoprenoid precursor molecules, and/or isoprenoids can be further enhanced by the heterologous expression of the mvaE and mvaS genes (such as, but not limited to, mvaE and mvaS genes from the organisms | 02-04-2016 |
| 20160115515 | GROUP OF GLYCOSYLTRANSFERASES AND USE THEREOF - Provided are the use of glycosyltransferases gGT25, gGT13, gGT30, gGT25-1, gGT25-3, gGT25-5, gGT29, gGT29-3, gGT29-4, gGT29-5, gGT29-6, gGT29-7, 3GT1, 3GT2, 3GT3, 3GT4 and derived polypeptides therefrom in the catalyzed glycosylation of terpenoid compounds and the synthesis of new saponins, wherein the glycosyltransferases can specifically and efficiently catalyze tetracyclic triterpenoid compound substrates at positions C-20 and/or C-6 and/or C-3 during hydroxyl glycosylation, and/or transfer the glycosyl from a glycosyl donor to the first glycosyl of the tetracyclic triterpenoid compounds at position C-3, so as to extend the sugar chain. The glycosyltransferases can also be used for constructing man-made synthetic rare ginsenosides and a variety of new ginsenosides and derivatives thereof. | 04-28-2016 |
| 20160122382 | PROCESSES FOR THE PREPARATION OF DEHYDROEPIANDROSTERONE AND ITS INTERMEDIATES - The present application relates to a regioselective and stereoselective processes for the preparation of dehydroepiandrosterone (DHEA) and processes for its intermediates. | 05-05-2016 |
| 20160194615 | Novel 7beta-Hydroxysteroid Dehydrogenases and Their Use | 07-07-2016 |
| 20160200992 | Enzymatic Hydrolysis of Acylated Steryl Glycosides and Method for Treating Biofuel | 07-14-2016 |
| 20190144808 | WELL INCLUDING A PIT | 05-16-2019 |
| 435053000 | Containing heterocyclic ring | 9 |
| 20090305338 | Plant cell lines established from the medicinal plant veratrum californicum - The present invention relates to the field of plant secondary metabolites. More particularly plant cell lines are established from the medicinal plant | 12-10-2009 |
| 20100209967 | PROCESS FOR THE SYNTHESIS OF 9A-HYDROXY-STEROIDS - The present invention relates to a novel selective synthesis of 9α-hydroxy-steroid derivatives of the general formula (I) (I)—wherein the meaning of -A-A′- is —CH | 08-19-2010 |
| 20120190063 | Rhodanobacter Ginsenosidimutans KCTC22231T-Derived Ginsenoside Glycosidase, and Use Thereof - The present invention relates to | 07-26-2012 |
| 20120264167 | NOVEL GINSENOSIDE GLYCOSIDASE DERIVED FROM THE GENUS TERRABACTER, AND USE THEREOF - The present invention relates to a novel ginsenoside glycosidase protein derived from the genus | 10-18-2012 |
| 20120288891 | PRODUCTION OF ACETYL-COENZYME A DERIVED COMPOUNDS - The present disclosure relates to the use of pantothenate compounds as a non-genetic switch for the production of heterologous acetyl-CoA derived (HACD) compounds in microbial host cells. The invention provides genetically modified microorganisms that are more stable when stored and initially cultured under reduced pantothenate concentrations, cell culture media having reduced concentrations of pantothenate compounds, and methods of producing HACD compounds using the cell culture media and the genetically engineered microorganisms of the invention. | 11-15-2012 |
| 20140147886 | METHOD TO INCREASE THE YIELD OF PRODUCTS IN PLANT MATERIAL - A method to increase the production of products of interest in plant material including plant cultures, such as, for example, cell suspension cultures, root cultures, and hairy root cultures is provided. In one embodiment, the method is to contacting the plant material with a precursor or xenobiotic when producing a product of interest from a plant. In another embodiment the plant material is also contacted with a trapping agent. The process may also provide for contacting an elicitor of the product of interest with the plant material. An embodiment provides for contacting an elicitor, precursor and trapping agent with the plant material. The ability to produce novel compounds such as glucosides and glucuronides is provided. | 05-29-2014 |
| 20140308698 | Methods and Materials for Enzymatic Synthesis of Mogroside Compounds - Methods and materials for enzymatic synthesis of mogroside compounds described. | 10-16-2014 |
| 20150064743 | Methods and Materials for Biosynthesis of Mogroside Compounds - The invention relates to methods for producing mogrosides with the aid of enzymes. In particular the invention proposes various biosynthetic pathways useful for mogroside production and enzymes useful for mogroside production are provided. Furthermore, the invention provides recombinant hosts useful in performing the methods of the invention. | 03-05-2015 |
| 20160083767 | NOVEL GLYCOSYLTRANSFERASE DERIVED FROM DOLWOE AND USE THEREOF - Provided are a novel UDP-glycosyltransferase (uridine diphosphate glycosyltransferase) protein having glycosyltransfer activity for glucose linked by a glycosidic bond at the C-20 position of PPD (protopanaxadiol)-type or PPT (protopanaxatriol)-type ginsenoside, and use thereof. | 03-24-2016 |
| 435054000 | Acting on D-ring | 3 |
| 20110124043 | Method of producing tibolone metabolites by fermentation with Gibberella fujikuroi - Method of producing Δ | 05-26-2011 |
| 435055000 | Acting at 17-position | 2 |
| 20110207172 | PROCESS FOR THE PREPARATION OF TESTOSTERONE - The present invention relates to an industrial process for the reduction of 4-androstene-3,17-dione in order to obtain testosterone using a particularly stable and selective enzyme produced in a recombinant manner. | 08-25-2011 |
| 20160376625 | Whole-Cell System For Cytochrome P450 Monooxygenases Biocatalysis - The subject of the present invention is a whole-cell catalysis process for converting substrates of cytochrome P450 monooxygenases of eukaryotic origin into valuable biotechnological products. The subject of the present invention is also microorganisms genetically engineered to achieve those biotransformations with high rates and processes to prepare these microorganism strains. | 12-29-2016 |
| 435058000 | Hydroxylating | 5 |
| 20090117612 | METHOD OF BIOOXIDATION USING AN OLD YELLOW ENZYME - A method for a chemoselective and regioselective enzyme mediated oxidation of carbon-hydrogen bonds of substrates using a | 05-07-2009 |
| 20090117613 | Method for redox reaction using an old yellow enzyme - A method of selective biooxidation to non activated carbon-hydrogen bonds of substances using a | 05-07-2009 |
| 20120231495 | PRODUCTION OF NON-YEAST STEROLS BY YEAST - This invention relates to the production of 7-dehydrocholesterol, 25-hydroxy-7-dehydrocholesterol, and 25-hydroxy ergosterol in yeast such as | 09-13-2012 |
| 20130040341 | NOVEL 7beta-HYDROXYSTEROID DEHYDROGENASES AND THEIR USE - The invention relates to novel 7β-hydroxysteroid dehydrogenases which are obtainable from bacteria of the genus | 02-14-2013 |
| 435059000 | At 11-position | 1 |
| 435060000 | At 11 alpha position | 1 |
| 20110124044 | Method of producing tibolone metabolites by fermentation with Cunninghamella elegans - A method of producing Δ | 05-26-2011 |
| 435061000 | Dehydrogenating; dehydroxylating | 4 |
| 20090280525 | PROCESS FOR THE ENANTIOSELECTIVE REDUCTION AND OXIDATION, RESPECTIVELY, OF STEROIDS - A process for the enantioselective enzymatic reduction of compounds which comprise a steroid structure (ABCD) including one or several heteroatoms, one or several double bonds and/or one aromatic component in the ring structure and have at least one oxo group at position 3, 7, 11, 12 or 17 in the steroid ring system or in the α-position at any carbon moiety on the steroid skeleton (=oxosteroid compound), | 11-12-2009 |
| 20140087421 | NOVEL 7Beta-HYDROXYSTEROID DEHYDROGENASE MUTANTS AND PROCESS FOR THE PREPARATION OF URSODEOXYCHOLIC ACID - The invention relates to novel 7β-hydroxysteroid dehydrogenase mutants, to the sequences which encode these enzyme mutants, to processes for the preparation of the enzyme mutants and to their use in enzymatic reactions of cholic acid compounds, in particular in the preparation of ursodeoxycholic acid (UDCS). The invention also relates to novel processes for the synthesis of UDCS using the enzyme mutants; and to the preparation of UDCS using recombinant, multiply-modified microorganisms. | 03-27-2014 |
| 20140147887 | NOVEL 12 ALPHA-HYDROXYSTEROID DEHYDROGENASES, PRODUCTION AND USE THEREOF - The invention provides 12α-hydroxysteroid dehydrogenases, nucleic acid sequences coding for the same, expression cassettes and vectors, recombinant microorganisms containing the corresponding coding nucleic acid sequences, methods for producing said 12α-hydroxysteroid dehydrogenases, methods for enzymatic oxidation of 12α-hydroxysteroids using said enzyme, methods for enzymatic reduction of 12-ketosteroids using said enzyme, methods for qualitative or quantitative determination of 12-ketosteroids and/or 12α-hydroxysteroids using said 12α-hydroxysteroid dehydrogenases and methods for production of ursodesoxycholic acid, comprising the enzyme-catalysed cholic acid oxidation using said 12α-hydroxysteroid dehydrogenases. | 05-29-2014 |
| 435062000 | Forming an aryl ring from "A" ring | 1 |
| 20090075328 | PROCESS FOR THE OVEREXPRESSION OF DEHYDROGENASES - A process for the overexpression of dehydrogenases, especially for the overexpression of Δ | 03-19-2009 |
